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The dark side of COVID‐19: The need of integrated medicine for children with special care needs | |
Cardiological Society of India: Document on Acute MI care during COVID-19 | Abstract The unprecedented and rapidly spreading Coronavirus Disease-19 (COVID-19) pandemic has challenged public health care systems globally. Based on worldwide experience, India has initiated a nationwide lockdown to prevent the exponential surge of cases. During COVID-19, management of cardiovascular emergencies li... |
Coincidence of COVID-19 Infection and Smell—Taste Perception Disorders | Many reports by physicians and patients during the 2019 to 2020 pandemic indicate that COVID-19 is associated with elevated levels of odor and taste perception disorders (anosmia, hyposmia, ageusia, and/or dysgeusia). Recent increase in olfactory dysfunction in patients referred to ear nose and throat clinics and COVID... |
Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase | Abstract The genetically diverse Orthocoronavirinae (CoV) family is prone to cross species transmission and disease emergence in both humans and livestock. Viruses similar to known epidemic strains circulating in wild and domestic animals further increase the probability of emergence in the future. Currently, there are... |
Does COVID-19 cause axonal GBS? | • Recent reports of Guillain-Barré Syndrome associated with COVID-19 have described both the axonal and demyelinating subtypes. • In this letter , I highlight features that suggest a predominantly axonal rather than demyelinating electrophysiology in these cases. |
The relationship of compassion and self-compassion with personality and emotional intelligence in organizations | The two studies presented in this article examine the relationships of personality traits and trait emotional intelligence (EI) with compassion and self-compassion in samples of Italian workers. Study 1 explored the relationship between trait EI and both compassion and self-compassion, controlling for the effects of pe... |
Viruses in asthma: The role of viruses in childhood respiratory infections | Current evidence suggests that the overall load of infectious agents, including respiratory viruses, encountered early in life is an important factor influencing maturation of the immune system from a type 2 bias at birth towards predominantly type 1 responses, thus avoiding atopic diseases. The ‘hygiene hypothesis’ pr... |
SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes | SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19 (COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over 21,000 deaths as of March 25, 2020. While under control in some affected Asian countries (Taiwan, Singapore, Vietnam), the virus demonstrated an exponenti... |
Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs | Severe acute respiratory syndrome (SARS) is an infectious disease caused by a newly identified human coronavirus (SARS-CoV). Currently, no effective drug exists to treat SARS-CoV infection. In this study, we investigated whether a panel of commercially available antiviral drugs exhibit in vitro anti–SARS-CoV activity. ... |
In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins | Coronavirus (CoV) replication and transcription are carried out in close proximity to restructured endoplasmic reticulum (ER) membranes in replication/transcription complexes (RTC). Many of the CoV nonstructural proteins (nsps) are required for RTC function; however, not all of their functions are known. nsp15 contains... |
COVID-19 and newborn health: systematic review | OBJECTIVE. To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2. METHODS. A systematic review was conducted by searching PubMed Central, LILACS, and Google Scholar using the keywords ‘covid ’ AND ‘newborn’ OR ‘child’ OR ‘infant,’ on 18 March 2020, and again on 17 April 2020. One researcher cond... |
The Molecular Biology of Coronaviruses | Abstract Coronaviruses are large, enveloped RNA viruses of both medical and veterinary importance. Interest in this viral family has intensified in the past few years as a result of the identification of a newly emerged coronavirus as the causative agent of severe acute respiratory syndrome (SARS). At the molecular lev... |
Making waves: Coronavirus detection, presence and persistence in the water environment: State of the art and knowledge needs for public health | The main route of transmission of the human coronaviruses (HCoVs), and presumably also of the new pandemic SARS-CoV-2, is via droplets and close contacts, however their fecal elimination also suggests the possible spread via water. A scientific literature search was thus carried out to highlight the current state of th... |
A review of bronchiolitis obliterans syndrome and therapeutic strategies | Lung transplantation is an important treatment option for patients with advanced lung disease. Survival rates for lung transplant recipients have improved; however, the major obstacle limiting better survival is bronchiolitis obliterans syndrome (BOS). In the last decade, survival after lung retransplantation has impro... |
Viral genome sequencing by random priming methods | BACKGROUND: Most emerging health threats are of zoonotic origin. For the overwhelming majority, their causative agents are RNA viruses which include but are not limited to HIV, Influenza, SARS, Ebola, Dengue, and Hantavirus. Of increasing importance therefore is a better understanding of global viral diversity to enabl... |
Evolution of infectious bronchitis virus in the field after homologous vaccination introduction | Despite the fact that vaccine resistance has been typically considered a rare phenomenon, some episodes of vaccine failure have been reported with increasing frequency in intensively-raised livestock. Infectious bronchitis virus (IBV) is a widespread avian coronavirus, whose control relies mainly on extensive vaccine a... |
Sustainable Designed Pavement Materials | This Special Issue “Sustainable Designed Pavement Materials” has been proposed and organized as a means to present recent developments in the field of environmentally-friendly designed pavement materials. For this reason, articles included in this special issue relate to different aspects of pavement materials, from in... |
Rumor Detection Based On Propagation Graph Neural Network With Attention Mechanism | Rumors on social media have always been an important issue that seriously endangers social security. Researches on timely and effective detection of rumors have aroused lots of interest in both academia and industry. At present, most existing methods identify rumors based solely on the linguistic information without co... |
Rapid Identification of the Mediterranean Fruit Fly (Diptera: Tephritidae) by Loop-Mediated Isothermal Amplification | The Mediterranean fruit fly, Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), ranks as one of the world’s most destructive agricultural pests. This pest is also widespread and highly invasive; thus, it is a high priority for pest detection and quarantine programs. Although Mediterranean fruit fly adult and third-... |
The polypeptides of human and mouse coronaviruses | The polypeptide compositions of two coronaviruses, human coronavirus strain 229E (HCV 229E) and mouse hepatitis virus strain 3 (MHV3), were characterised on polyacrylamide gels. Similar polypeptide patterns were observed for both viruses consisting of large surface projection glycopolypeptides of mol. wt. 160,000 and 1... |
Decrease in Hospital Admissions for Transient Ischemic Attack, Mild, and Moderate Stroke During the COVID-19 Era | Since the onset of the coronavirus 2019 (COVID-19) pandemic, doctors and public authorities have demonstrated concern about the reduction in quality of care for other health conditions due to social restrictions and lack of resources. Using a population-based stroke registry, we investigated the impact of the onset of ... |
Ultra-rapid delivery of specialty field hospitals to combat COVID-19: Lessons learned from the Leishenshan Hospital project in Wuhan | With the outbreak of the 2019 novel coronavirus (COVID-19) epidemic in Wuhan, China, in January 2020, the escalating number of confirmed and suspected cases overwhelmed the admission capacity of the designated hospitals. Two specialty field hospitals—Huoshenshan and Leishenshan—were designed, built and commissioned in ... |
Comment on: COVID‐19 pandemic: perspectives on an unfolding crisis – a UK perspective | |
Acute Life-threatening Cardiac Tamponade in a Mechanically Ventilated Patient with COVID-19 Pneumonia | Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently evolved as a pandemic disease. Although the respiratory system is predominantly affected, cardiovascular complications have been frequently identified, including acute myocarditis, myocardial infarcti... |
Concerns about pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) studies in the new therapeutic area of COVID-19 infection | In the context of the COVID-19 pandemic, several drugs have been repurposed as potential candidates for the treatment of COVID-19 infection. While preliminary choices were essentially based on in vitro potency, clinical translation into effective therapies may be challenging due to unfavorable in vivo pharmacokinetic p... |
Surface-displayed porcine reproductive and respiratory syndrome virus from cell culture onto gram-positive enhancer matrix particles | Vaccine immunization is now one of the most effective ways to control porcine reproductive and respiratory syndrome virus (PRRSV) infection. Impurity is one of the main factors affecting vaccine safety and efficacy. Here we present a novel innovative PRRSV purification approach based on surface display technology. Firs... |
Precautions and recommendations for orthodontic settings during the COVID-19 outbreak: A review | Abstract Introduction Coronavirus disease 2019 (COVID-19) is contagious disease caused by the SARS-CoV-2 virus. It emerged as a global pandemic early in 2020, affecting more than 2000 countries and territories. The infection is highly contagious with disease transmission reported from asymptomatic carriers, including c... |
Sektion Pflege zur aktuellen Situation der Intensivpflege in Deutschland: Arbeitsgruppe der Sektion Pflege der Deutschen Gesellschaft für Internistische Intensivmedizin und Notfallmedizin (DGIIN) | The year 2020 is the year of care on the occasion of the 200th birthday of Florence Nightingale. However, due to current events, the “Year of Corona” will be remembered more. A positive aspect is the attention and appreciation of the nursing profession in the population. Nevertheless, politicians and various profession... |
Recent advances in peptide chain termination | Peptide chain termination occurs when a stop codon is decoded by a release factor. In Escherichia coli two codon‐specific release factors (RF1 and RF2) direct the termination of protein synthesis, while in eukaryotes a single factor is required. The E. coli factors have been purified and their genes isolated. A combina... |
Epidemiological analysis of COVID‐19 and practical experience from China | The rapid spread of the epidemic has aroused widespread concern in the international community. Severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) originated from Wuhan's Huanan wholesale seafood market, with bats as the likely original hosts and pangolins as potential intermediate hosts. The current source o... |
Acute Coronary Syndromes and Covid-19: Exploring the Uncertainties. | Since an association between myocardial infarction (MI) and respiratory infections has been described for influenza viruses and other respiratory viral agents, understanding possible physiopathological links between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and acute coronary syndromes (ACS) is of th... |
Automatically fixing errors in glycoprotein structures with Rosetta | Recent advances in single-particle cryo-electron microscopy (cryoEM) have resulted in determination of an increasing number of protein structures with resolved glycans. However, existing protocols for the refinement of glycoproteins at low resolution have failed to keep up with these advances. As a result, numerous dep... |
State of cat genomics | Our knowledge of cat family biology was recently expanded to include a genomics perspective with the completion of a draft whole genome sequence of an Abyssinian cat. The utility of the new genome information has been demonstrated by applications ranging from disease gene discovery and comparative genomics to species c... |
Development of a Surgical Workforce Access Team (SWAT) in the Battle Against COVID-19 | |
Microbiologic Investigations for Head and Neck Infections | A variety of methods, including direct examination of stained smears, antigen detection, routine and special cultures, and histopathologic evaluation are available for investigation of head and neck infections. Newer rapid molecular techniques with increased sensitivity and specificity are becoming available at many ce... |
Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases | Picornaviruses form replication complexes in association with membranes in structures called replication organelles. Common themes to emerge from studies of picornavirus replication are the need for cholesterol and phosphatidylinositol 4-phosphate (PI4P). In infected cells, type III phosphatidylinositol 4-kinases (PI4K... |
The role of infections in the emergence of non-communicable diseases (NCDs): Compelling needs for novel strategies in the developing world | Summary The emergence of non-communicable diseases (NCDs) follows multiple aetiological pathways requiring recognition for effective control and prevention. Infections are proving to be conventional, emerging and re-emerging aetiological factors for many NCDs. This review explores the possible mechanisms by which infec... |
Emerging Molecular Assays for Detection and Characterization of Respiratory Viruses | This article describes several emerging molecular assays that have potential applications in the diagnosis and monitoring of respiratory viral infections. These techniques include direct nucleic acid detection by quantum dots, loop-mediated isothermal amplification, multiplex ligation-dependent probe amplification, amp... |
Persistent viral shedding of SARS‐CoV‐2 in faeces – a rapid review | AIM: In addition to respiratory symptoms, COVID‐19 can present with gastrointestinal complaints suggesting possible faeco‐oral transmission. The primary aim of this review was to establish the incidence and timing of positive faecal samples for SARS‐CoV‐2 in patients with COVID‐19. METHODS: A systematic literature revi... |
Do crocodilians get the flu? Looking for influenza A in captive crocodilians | It is well established that several wild aquatic bird species serve as reservoirs for the influenza A virus. It has also been shown that the influenza A virus can be transmitted to mammalian species such as tigers and domestic cats and dogs through ingestion of infected birds. Another group of animals that should also ... |
Impact of COVID‐19 on clinical practice | |
Danger of Potential-Pandemic-Pathogen Research Enterprises | |
Long-Term Care Facilities: A Cornucopia of Viral Pathogens | OBJECTIVES: To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period. DESIGN: Observational. SETTING: Thirty-three Boston-area LTCFs over a 3-year period. PARTICIPANTS: Residents of long-term care who had previously participated in a tria... |
Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation | BACKGROUND: Porcine parvovirus (PPV) infection primarily causes reproductive failure of pregnant swine and results in host cell death. Boars, as an important disseminator, shed PPV to sows via semen. PPV infects and numerously replicates in boar testicle, which results in damage of swine testicle in vivo. Reactive oxyg... |
Incidence of anogenital warts in Liuzhou, south China: a comparison of data from a prospective study and from the national surveillance system | To determine the incidence of anogenital warts (AGWs) in the Chinese general population, we compared the data from a prospective study and from the National Notifiable Disease Report System (NNDRS). A cohort study including 2378 women and 2309 men aged 18–55 years old enrolled from Liuzhou, China, was conducted with th... |
Strengthening laboratory capacity for detection of respiratory viral pathogens through the Global Health Security Agenda (GHSA) framework | BACKGROUND: Endemic and emerging respiratory viruses are a threat to public health, and a robust public health laboratory system is essential to ensure global health security. OBJECTIVE: This program sought to expand molecular laboratory testing capacity to detect a broad range of respiratory pathogens in clinical resp... |
Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia, March to June 2014 | BACKGROUND AND OBJECTIVES: Describe the epidemiology and characteristics of Middle East respiratory syndrome coronavirus (MERS-CoV), which are essential for control and treatment. METHODS: We conducted a retrospective review of all cases of MERS-CoV reported in four cities of the Makkah Region from March to June 2014. ... |
Mortality estimates among adult patients with severe acute respiratory infections from two sentinel hospitals in southern Arizona, United States, 2010–2014 | BACKGROUND: From October 2010 through February 2016, Arizona conducted surveillance for severe acute respiratory infections (SARI) among adults hospitalized in the Arizona-Mexico border region. There are few accurate mortality estimates in SARI patients, particularly in adults ≥ 65 years old. The purpose of this study ... |
Investigating a safe ventilation rate for the prevention of indoor SARS transmission: An attempt based on a simulation approach | This paper identifies the “safe ventilation rate” for eliminating airborne viral infection and preventing cross-infection of severe acute respiratory syndrome (SARS) in a hospital-based setting. We used simulation approaches to reproduce three actual cases where groups of hospital occupants reported to be either infect... |
Beatmung geriatrischer Patienten — ein ethisches Dilemma?: Corona-Pandemie 2020 | Dieser Beitrag möchte einen Überblick darüber geben, wie und mit Hilfe welcher Kriterien eine medizinisch, ethisch und rechtlich vertretbare Entscheidung darüber getroffen werden kann, welche der betagten Patienten mit einer schweren COVID-19-Pneumonie mittels künstlicher Beatmung behandelt werden sollten und welche vo... |
TLR3 Signaling in Macrophages Is Indispensable for the Protective Immunity of Invariant Natural Killer T Cells against Enterovirus 71 Infection | Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wit... |
Differential induction of apoptosis in demyelinating and nondemyelinating infection by mouse hepatitis virus | The role of apoptosis in mouse hepatitis virus (MHV) infection is still controversial. To better assess the role of apoptosis in MHV infection, we used three different biologic phenotypes of MHV to examine their differential effect on the induction of apoptosis. MHV-A59 produces acute hepatitis, meningoencephalitis, an... |
Social media and moral panics: Assessing the effects of technological change on societal reaction | Answering calls for deeper consideration of the relationship between moral panics and emergent media systems, this exploratory article assesses the effects of social media – web-based venues that enable and encourage the production and exchange of user-generated content. Contra claims of their empowering and deflationa... |
Comment réaliser un prélèvement rhinopharyngé chez l’adulte et l’enfant en période de la pandémie de la maladie COVID-19 | Abstract The nasopharyngeal swab is currently the main testing method used to diagnose COVID-19. The principle is to collect respiratory cells infected by the virus and to use the RT-PCR (Reverse Transcription - Polymerase Chain Reaction) technique to detect the RNA of the virus. The false negative rate is high, about ... |
12 Phytochemical and biological research of Polygoneae medicinal resources | Abstract This chapter synthesizes current knowledge on phytochemistry, bioactivity, molecular phylogeny, and omics of Polygoneae medicinal resources. Many species in the seven genera of Polygoneae are traditional and popular medicinal herbs. Anthraquinones and stilbenes are characteristic medicinal compounds of Polygon... |
Advice on Standardized Diagnosis and Treatment for Spinal Diseases during the Coronavirus Disease 2019 Pandemic | Coronavirus disease 2019 (COVID-19) outbreak started in December 2019 that caused difficulties for clinical work. Practical work experience in our spinal outpatient and emergency department during the COVID-19 pandemic is summarized in this article, with combined evidence-based medical evidence to explore a standardize... |
Renin-angiotensin system at the heart of COVID-19 pandemic | Abstract Significant aspects of COVID-19 pandemic remain obscure. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system, whose expression dominates on lung alveolar epithelial cells, is the human cell receptor of SARS-CoV-2, the causative agent of COVID-19. We strongly encourage the concep... |
Différence de diagnostic des infections broncho-pulmonaires virales ou bactériennes chez l'enfant | Résumé Les bronchopneumopathies communautaires de l'enfant sont fréquentes et entraînent une morbidité importante. Elles peuvent se décomposer en bronchiolites, qui sont toutes d'origine virale, bronchites (ou trachéobronchites), qui sont aussi d'origine virale le plus souvent (80 %) et qui se surinfectent parfois, pne... |
A crude future? COVID-19s challenges for oil demand, supply and prices | Assessing prospects for future oil prices is an uncertain activity but, barring Middle East conflict creating severe supply issues, crude oil prices are expected to stage a recovery by third-quarter 2020 and modest further recovery in first-half 2021, with the range $40 to $60 per barrel for WTI and Brent. Despite such... |
Synthetic Biology: Mapping the Scientific Landscape | This article uses data from Thomson Reuters Web of Science to map and analyse the scientific landscape for synthetic biology. The article draws on recent advances in data visualisation and analytics with the aim of informing upcoming international policy debates on the governance of synthetic biology by the Subsidiary ... |
Identifying Behavioral Risk Intervention Points to Prevent Zoonotic Spillover at Animal Markets, Farms, and Abattoirs in Egypt | |
Acute Encephalitis | Acute encephalitis remains one of the contemporary challenges of critical care medicine. The diagnosis is difficult and sometimes unconfirmed, and encephalitis remains without clear evidence-based therapies or even therapeutic goals for the prevention of high neurologic sequelae. This article provides a framework for p... |
Potential effective treatment for COVID-19: systematic review and meta-analysis of the severe infectious disease with convalescent plasma therapy | Abstract Background Convalescent plasma (CP) has been used successfully to treat many types of infectious diseases, and it has shown initial effects in the treatment of the emerging 2019 coronavirus disease (COVID-19). However, its curative effect and feasibility have yet to be confirmed by formal evaluation and well-d... |
Impact of Severe Acute Respiratory Syndrome (SARS) on Blood Services and Blood in Hong Kong in 2003 | The current global pandemic of COVID‐19 due to the novel coronavirus SARS‐CoV‐2 is causing considerable loss of life and enormous social and economic disruption. Here, we describe the response of the blood service, the impact on blood donation and the effects on the blood supply in Hong Kong posed by the earlier SARS e... |
Oxymetazoline modulates proinflammatory cytokines and the T‐cell stimulatory capacity of dendritic cells | Abstract: The nasal decongestant oxymetazoline (OMZ) is frequently used in the topical treatment of rhinitis/sinusitis. As proinflammatory cytokines play a critical role in the development and maintenance of local inflammation, the aim of this study was to investigate the influence of OMZ on immune cells in order to di... |
Respiratory viruses in children with cystic fibrosis: viral detection and clinical findings | Please cite this paper as: Burns et al. (2011) Respiratory viruses in children with cystic fibrosis: viral detection and clinical findings. Influenza and Other Respiratory Viruses 6(3), 218–223. Background Viral detection from different respiratory sample types in children with cystic fibrosis (CF) is facilitated by av... |
An immunohistochemical investigation of porcine epidemic diarrhoea | Summary A sudden outbreak of epidemic diarrhoea of piglets occurred in Japan, the principal features being watery diarrhoea, dehydration and high mortality in newborn animals. The microscopical lesions were villous atrophy in the small intestine, the villous enterocytes being vacuolated and cuboidal in shape. The villu... |
Increased severity of COVID‐19 in people with obesity: are we overlooking plausible biological mechanisms? | The relationship between obesity and more severe disease in patients with COVID‐19 is intriguing. Recent articles published in Obesity (1‐3) discuss the possible effects of increased proinflammatory cytokines and disturbances of lung function in people with obesity, but we believe that they overlook an important player... |
A comprehensive assessment of N-terminal signal peptides prediction methods | BACKGROUND: Amino-terminal signal peptides (SPs) are short regions that guide the targeting of secretory proteins to the correct subcellular compartments in the cell. They are cleaved off upon the passenger protein reaching its destination. The explosive growth in sequencing technologies has led to the deposition of va... |
Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak | Backgrounds An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit a major city of China, Wuhan, December 2019 and subsequently reached other provinces/regions of China and countries. We present estimates of the basic reproduction number, R0, of 2019-nCoV in the early phase of the outbreak. Methods Accoun... |
Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents | Six series of semisynthetic lipophilic glycopeptide antibiotic derivatives were evaluated for in vitro activity against influenza A and B viruses. The new teicoplanin pseudoaglycon-derived lipoglycopeptides were prepared by coupling one or two side chains to the N-terminus of the glycopeptide core, using various conjug... |
Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig | BACKGROUND: In this study, porcine encephalomyocarditis virus (EMCV) virus-like particles (VLPs) were generated using a baculovirus expression system and were tested for immunogenicity and protective efficacy in vivo. RESULTS: VLPs were successfully generated from Sf9 cells infected with recombinant baculovirus and wer... |
The tree shrew provides a useful alternative model for the study of influenza H1N1 virus | BACKGROUND: The influenza pandemics have resulted in significant morbidity and mortality worldwide. Animal models are useful in the study of influenza virus pathogenesis. Because of various limitations in current laboratory animal models, it is essential to develop new alternative animal models for influenza virus rese... |
How we treat patients with brain tumour during the COVID-19 pandemic | The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. This is particularly true in the field of neuro-oncology, where the perceived benefit of therapeutic interventions is often low,... |
COVID-19-Risikopatienten mit Echo-Marker identifizieren | |
Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair | Neurodegeneration is a hallmark of many diseases and disorders of the central nervous system (CNS). High levels of neuroinflammation are often associated with irreparable damage to CNS cells due to the dysregulation of signaling cascades that are unable to restore a homeostatic balance. Due to the inherent complexity o... |
Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells | Selection of single antigen-specific B cells to identify their expressed antibodies is of considerable interest for evaluating human immune responses. Here, we present a method to identify single antibody-expressing cells using antigen-conjugated fluorescent beads. To establish this, we selected Folate Receptor alpha (... |
Studies with an unclassified virus isolated from diarrheic calves | Abstract A transmissible agent (Breda agent) was isolated from a calf with diarrhea and shown to be infectious by inoculation orally into gnotobiotic and conventionally reared calves. The “Breda” agent had the morphology of a virus and possessed a hemagglutinin. Antigenic studies showed the virus to be antigenically di... |
Nocturnal oxygen therapy as an option for early COVID-19 | Abstract Currently, there is no effective antiviral therapy or immune-based treatments for coronavirus disease (COVID-19), and the urgent challenge is to prevent the transition of COVID-19 from mild to severe. In this paper, we provide nocturnal oxygen therapy as a new option for the patients with COVID-19 under home q... |
Management of a patient presenting with anterior STEMI with concomitant COVID‐19 infection early in the course of the U.S. pandemic | The coronavirus disease‐2019 (COVID‐19) is a viral illness with heterogenous clinical manifestations, ranging from mild symptoms to severe acute respiratory distress syndrome and shock caused by the severe acute respiratory syndrome coronavirus‐2. The global healthcare community is rapidly learning more about the effec... |
Hidradenitis suppurativa: the importance of virtual outpatient care during COVID-19 pandemic | |
Demographic and Health Indicators in Correlation to Interstate Variability of Incidence, Confirmation, Hospitalization, and Lethality in Mexico: Preliminary Analysis from Imported and Community Acquired Cases during COVID-19 Outbreak | This study’s objective is to analyze the incidence, lethality, hospitalization, and confirmation of COVID-19 cases in Mexico. Sentinel surveillance for COVID-19 cases in Mexico began after the confirmation of the first patient with community transmission. Methods: This epidemiologic, cross-sectional study includes all ... |
Modeling the spread of bird flu and predicting outbreak diversity | Abstract Avian influenza, commonly known as bird flu, is an epidemic caused by H5N1 virus that primarily affects birds like chickens, wild water birds, etc. On rare occasions, these can infect other species including pigs and humans. In the span of less than a year, the lethal strain of bird flu is spreading very fast ... |
High-Risk Airway Management in the Emergency Department: Diseases and Approaches Part I | Abstract Background Successful airway management is critical to the practice of emergency medicine. Thus, emergency physicians must be ready to optimize and prepare for airway management in critically ill patients with a wide range of physiologic challenges. Challenges in airway management commonly encountered in the e... |
A generalized approach to predicting protein-protein interactions between virus and host | BACKGROUND: Viral infection involves a large number of protein-protein interactions (PPIs) between virus and its host. These interactions range from the initial binding of viral coat proteins to host membrane receptor to the hijacking the host transcription machinery by viral proteins. Therefore, identifying PPIs betwe... |
COVID 19 in INDIA: Strategies to combat from combination threat of life and livelihood | Abstract INDIA- As for reported in 360 COVID-19 cases (till March 22, 2020), seven people were died, and 23 people were treated successfully.1 This virus can easily affect who having respiratory problem and especially who all have been aged older than sixty. Most of the affected peoples had reached India from different... |
Unveiling the druggable RNA targets and small molecule therapeutics | Abstract The increasing appreciation for the crucial roles of RNAs in infectious and non-infectious human diseases makes them attractive therapeutic targets. Coding and non-coding RNAs frequently fold into complex conformations which, if effectively targeted, offer opportunities to therapeutically modulate numerous cel... |
Implementation of Artifact Detection in Critical Care: A Methodological Review | Artifact Detection (AD) techniques minimize the impact of artifacts on physiologic data acquired in Critical Care Units (CCU) by assessing quality of data prior to Clinical Event Detection (CED) and Parameter Derivation (PD). This methodological review introduces unique taxonomies to synthesize over 80 AD algorithms ba... |
Viral infections of the CNS with special emphasis on herpes simplex infections | Within the past decade the management of acute HSV I encephalitis has been improved dramatically by the advent of the polymerase chain reaction (PCR), a method which has become the gold standard of diagnosis of HSV I encephalitis, replacing diagnostic uncertainties and, avoiding, in particular, invasive brain biopsy. E... |
Identification of viral agents causing diarrhea among children in the Eastern Center of Tunisia | Viral diarrhea remains a major cause of childhood morbidity and mortality worldwide. In Tunisia, no comprehensive studies of all viral agents related to diarrhea in children have yet been conducted. The present study was performed to investigate the role of enteric viruses in acute diarrhea in the country. Six hundred ... |
Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients | Abstract Background The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. Methods Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for l... |
Letter To the Editor: [Our Response to COVID-19 as Endocrinologists and Diabetologists] | |
Small G Rac1 is involved in replication cycle of dengue serotype 2 virus in EAhy926 cells via the regulation of actin cytoskeleton | Bleeding is a clinical characteristic of severe dengue and may be due to increased vascular permeability. However, the pathogenesis of severe dengue remains unclear. In this study, we showed that the Rac1-microfilament signal pathway was involved in the process of DENV serotype 2 (DENV2) infection in EAhy926 cells. DEN... |
Can Users Search Trends Predict People Scares or Disease Breakout? An Examination of Infectious Skin Diseases in the United States | BACKGROUND: In health and medicine, people heavily use the Internet to search for information about symptoms, diseases, and treatments. As such, the Internet information can simulate expert medical doctors, pharmacists, and other health care providers. AIM: This article aims to evaluate a dataset of search terms to det... |
Influenza Research in the Soviet Union—1974 | |
Human respiratory syncytial virus in children with lower respiratory tract infections or influenza-like illness and its co-infection characteristics with viruses and atypical bacteria in Hangzhou, China | Abstract Background Human respiratory syncytial virus (RSV) is the most important viral pathogen in children. However, its epidemic patterns and co-infection characteristics are not fully understood. Objectives We attempted to determine the level of genetic variation of RSV, and describe the prevalence and co-infection... |
Viral metagenomics reveals the presence of highly divergent quaranjavirus in Rhipicephalus ticks from Mozambique | Background: Ticks are primary vectors for many well-known disease-causing agents that affect human and animal populations globally such as tick-borne encephalitis, Crimean-Congo hemorrhagic fever and African swine fever. In this study, viral metagenomics was used to identify what viruses are present in Rhipicephalus sp... |
Comparison of commercial RT-PCR diagnostic kits for COVID-19 | Abstract The final months of 2019 witnessed the emergence of a novel coronavirus in the human population. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has since spread across the globe and is posing a major burden on society. Measures taken to reduce its spread critically depend on timely and accurate i... |
Recently published papers: small pieces of the puzzle and the long-term view | |
How the Irish Competition and Consumer Protection Commission is responding to the COVID-19 challenge |
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