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Shelter hospital mode: How do we prevent COVID-19 hospital-acquired infection? | |
Mental health among otolaryngology resident and attending physicians during the COVID‐19 pandemic: National study | BACKGROUND: Otolaryngologists are among the highest risk for COVID‐19 exposure. METHODS: This is a cross‐sectional, survey‐based, national study evaluating academic otolaryngologists. Burnout, anxiety, distress, and depression were assessed by the single‐item Mini‐Z Burnout Assessment, 7‐item Generalized Anxiety Disord... |
Unfolding SARS-CoV-2 viral genome to understand its gene expression regulation | SARS-CoV-2 is a new virus responsible for an outbreak of respiratory illness known as COVID-19, which has spread to several countries around the world and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In silico analysis of the transcription start site... |
The propagation of “coronaviruses” in tissue-culture | The conditions for the cultivation of the 229-E respiratory virus in tissue culture are described. The virus multiplies only in human tissue culture systems, but a variety of cell types are sensitive to it. The virus has been isolated in three continuous cell lines and a plaque assay has been developed in one of these.... |
Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits | Immaturity of the neonatal immune system is causative for high morbidity in calves and colostrum intake is crucial for acquiring passive immunity. Pathogenesis is promoted by reactive oxygen species accumulating at birth if counter-regulation is inadequate. The flavonol quercetin exerts antioxidative and anti-inflammat... |
The regulation mechanism of lncRNAs and mRNAs in sea cucumbers under global climate changes: Defense against thermal and hypoxic stresses | Abstract The aquatic environment can be greatly impacted by thermal and hypoxic stresses, particularly caused by intensified global warming. Hence, there is an urgency to understand the response mechanisms of marine organisms to adverse environment. Although long non-coding RNAs (lncRNAs) are involved in many biologica... |
One Health-based control strategies for MERS-CoV | |
Efficacy of a Carrageenan nasal spray in patients with common cold: a randomized controlled trial | BACKGROUND: The common cold is the most widespread viral infection in humans. Iota-carrageenan has previously shown antiviral effectiveness against cold viruses in clinical trials. This study investigated the efficacy of a carrageenan-containing nasal spray on the duration of the common cold and nasal fluid viral load ... |
A brief history of risk | Despite increasing life expectancy and high levels of welfare, health care, and public safety in most post-industrial countries, the public discourse often revolves around perceived threats. Terrorism, global pandemics, and environmental catastrophes are just a few of the risks that dominate media coverage. Is this pub... |
Projecting social contact matrices in 152 countries using contact surveys and demographic data | Heterogeneities in contact networks have a major effect in determining whether a pathogen can become epidemic or persist at endemic levels. Epidemic models that determine which interventions can successfully prevent an outbreak need to account for social structure and mixing patterns. Contact patterns vary across age a... |
The airborne transmission of infection between flats in high-rise residential buildings: Particle simulation | Abstract Several case clusters occurred in high-rise residential buildings in Hong Kong in the 2003 SARS (the severe acute respiratory syndrome) epidemic, which motivated a series of engineering investigations into the possible airborne transport routes. It is suspected that, driven by buoyancy force, the polluted air ... |
Antiviral activity of berberine | Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle a... |
Not so soft soap | |
Impact of targeted vaccination on HBV genotypes in Amsterdam | |
Effects of AntagomiRs on Different Lung Diseases in Human, Cellular, and Animal Models | Introduction: MiRNAs have been shown to play a crucial role among lung cancer, pulmonary fibrosis, tuberculosis (TBC) infection, and bronchial hypersensitivity, thus including chronic obstructive pulmonary disease (COPD) and asthma. The oncogenic effect of several miRNAs has been recently ruled out. In order to act on ... |
Monitoring and Characterization of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Japan, 2009–2010 | To monitor and characterize oseltamivir-resistant (OR) pandemic (H1N1) 2009 virus with the H275Y mutation, we analyzed 4,307 clinical specimens from Japan by neuraminidase (NA) sequencing or inhibition assay; 61 OR pandemic (H1N1) 2009 viruses were detected. NA inhibition assay and M2 sequencing indicated that OR pande... |
The first detection and full-length genome sequence of porcine deltacoronavirus isolated in Lao PDR | Porcine deltacoronavirus (PDCoV) has been reported in many countries, including Hong Kong, the United States, South Korea, China and Thailand. In January 2016, clinical diarrhea similar to that of porcine epidemic diarrhea virus (PEDV) with a lower mortality rate was reported on a swine farm in Lao PDR. Intestine sampl... |
Violencia doméstica entre los ancianos durante la pandemia COVID-19 | |
Impact of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on COVID-19 in a western population. CARDIOVID registry | ABSTRACT Introduction and objectives: Coronavirus disease (COVID-19) has been designated a global pandemic by the World Health Organization. It is unclear whether previous treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) affects the prognosis of COVID-19 patients. T... |
COVID-19 zugzwang: potential public health moves towards population (herd) immunity | Summary COVID-19 is pandemic, and likely to become endemic, possibly returning with greater virulence. Outlining potential public health actions, including hygiene measures, social distancing and face masks, and realistic future advances, this paper focuses on the consequences of taking no public health action; the rol... |
Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers | ACE2, in concert with the protease TMPRSS2, binds the novel coronavirus SARS-CoV-2 and facilitates its cellular entry. The ACE2 gene is expressed in SARS-CoV-2 target cells, including Type II Pneumocytes (Ziegler, 2020), and is activated by interferons. Viral RNA was also detected in breast milk (Wu et al., 2020), rais... |
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia | BACKGROUND: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. OBJECTIVES: To describe the coagulation feature of patients with NCP. METHODS: Conventional coagulation results and outcomes ... |
Características epidemiológicas, clínicas y terapéuticas de lactantes hospitalizados por bronquiolitis | Resumen Objetivos Describir los datos epidemiológicos, clínicos y actitud terapéutica empleada en los lactantes hospitalizados por bronquiolitis en nuestro medio. Material y métodos Estudio observacional, descriptivo y prospectivo de lactantes menores de 18 meses ingresados en Hospital Virgen de la Arrixaca (Murcia) co... |
The route of inoculation determines the tissue tropism of modified vaccinia tiantan expressing the spike glycoprotein of SARS‐CoV in mice, | The live replication‐competent modified vaccinia virus Tiantan (MVTT) is an attractive vaccine vector, yet little is known about its tissue tropism and pathology in vivo. Recently, we demonstrated that a recombinant MVTT expressing the spike glycoprotein of SARS‐CoV (namely MVTT‐S) is superior to the non‐replicating mo... |
Recommendations and guidance for providing pharmaceutical care services during COVID-19 pandemic: A China perspective | Abstract Background The novel coronavirus pneumonia (COVID-19), which was first detected in Wuhan City, has now became a pandemic that affecting patients around the world. Particularly, the community patient population are at high risk of infection and are facing potential failure of proper medication use during the pa... |
SARS Risk Perceptions in Healthcare Workers, Japan | In coping with severe acute respiratory syndrome (SARS), infection control measures are a key aspect of protecting healthcare workers. We conducted a survey concerning perception of risk and countermeasures for SARS in 7 tertiary hospitals in Japan from July through September 2003, immediately after the SARS epidemic i... |
Spread from the Sink to the Patient: In Situ Study Using Green Fluorescent Protein (GFP)-Expressing Escherichia coli To Model Bacterial Dispersion from Hand-Washing Sink-Trap Reservoirs | There have been an increasing number of reports implicating Gammaproteobacteria as often carrying genes of drug resistance from colonized sink traps to vulnerable hospitalized patients. However, the mechanism of transmission from the wastewater of the sink P-trap to patients remains poorly understood. Herein we report ... |
COVID Curve Guides India’s Health Infrastructure Growth Needs | COVID-19 has led to many unprecedented situations across the world. With lockdowns and severe restrictions on movement and activities, countries have managed to slow down the COVID curve but developing countries like India are likely to face a humongous task of containing the virus spread in coming months. High populat... |
Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses | Human respiratory syncytial virus (RSV) is the most important cause of acute lower respiratory tract disease in infants worldwide. As a first line of defense against respiratory infections, innate immune responses, including the production of type I and III interferons (IFNs), play an important role. Upon infection wit... |
Immune‐related Factors Associated with Pneumonia in 127 Children with Coronavirus Disease 2019 in Wuhan | OBJECTIVE: Information regarding the association of immune‐related factors with pneumonia in children with coronavirus disease 2019 (COVID‐19) is scarce. This study aims to summarize the immune‐related factors and their association with pneumonia in children with COVID‐19. METHODS: Children with COVID‐19 at Wuhan Child... |
International perspectives: Impact of the COVID‐19 pandemic on cytology | |
Analysis of dermatology-related search engine trends during the COVID-19 pandemic: implications for patient demand for outpatient services and telehealth. | |
The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus | Abstract The spike protein of Porcine epidemic diarrhea virus is the main surface glycoprotein involved in virus attachment and entry and therefore is the target of neutralizing antibodies. Here, the immunogenicity of a novel antigenic domain found on the carboxy-terminal of the spike protein characterized by the pepti... |
Spontaneous coronary artery dissection of the left anterior descending artery in a patient with COVID‐19 infection | A 48‐year‐old woman with a past medical history of migraines and hyperlipidemia presented due to severe retrosternal chest pain with no other associated signs or symptoms. The patient was hemodynamically stable and was found to have an elevated troponin with electrocardiogram showing no ischemic changes. Computed tomog... |
Identification of essential residues in potyvirus proteinase HC-pro by site-directed mutagenesis | Abstract Two virus-encoded proteinases are responsible for proteolysis of potyvirus polyproteins. One of these, HC-Pro, is a multifunctional protein that autolytically cleaves at its carboxyl-terminus (J. C. Carrington et al., 1989, EMBO J. 8, 365–370). To identify the class of proteinase to which HC-Pro belongs, tobac... |
Characteristics of inflammatory factors and lymphocyte subsets in patients with severe COVID‐19 | To investigate the inflammatory factors and lymphocyte subsets which play an important role in the course of severe coronavirus disease 2019 (COVID‐19). A total of 27 patients with severe COVID‐19 who were admitted to Tongji Hospital in Wuhan from 1 to 21 February 2020 were recruited to the study. The characteristics o... |
Capter 11 Filtering in Drug Discovery | Publisher Summary This chapter discusses the concept of filtering in drug discovery. Multiple filters may be incorporated into a definition of drug-likeness and this leads to tradeoffs among compound properties in compounds intended for screening. The optimization of compound properties may require some type of multipara... |
The Evolution of Poxvirus Vaccines | After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, passaged in cattle and ... |
Stap vooruit in onderzoek naar preventie | |
Conveyance Contact Investigation for Imported Middle East Respiratory Syndrome Cases, United States, May 2014 | In 2014, the Centers for Disease Control and Prevention conducted conveyance contact investigations for 2 Middle East respiratory syndrome cases imported into the United States, comprising all passengers and crew on 4 international and domestic flights and 1 bus. Of 655 contacts, 78% were interviewed; 33% had serologic... |
Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor | Bluetongue (BT) is a noncontagious, insect-transmitted disease of ruminants caused by the bluetongue virus (BTV). A laboratory animal model would greatly facilitate the studies of pathogenesis, immune response and vaccination against BTV. Herein, we show that adult mice deficient in type I IFN receptor (IFNAR((−/−))) a... |
Phylodynamic analysis of avian infectious bronchitis virus in South America | Infectious bronchitis virus (IBV) is a coronavirus of chickens that causes great economic losses to the global poultry industry. The present study focuses on South American IBVs and their genetic relationships with global strains. We obtained full-length sequences of the S1 coding region and N gene of IBV field isolate... |
Canine parvovirus: a predicting canine model for sepsis | BACKGROUND: Sepsis is a severe condition associated with high prevalence and mortality rates. Parvovirus enteritis is a predisposing factor for sepsis, as it promotes intestinal bacterial translocation and severe immunosuppression. This makes dogs infected by parvovirus a suitable study population as far as sepsis is c... |
The Coronavirus Replicase: Insights into a Sophisticated Enzyme Machinery | |
Chapter 6 Natural Product Inhibitors of Ubiquitin Conjugation and Deconjugation | Abstract The ubiquitin–proteasome system has been recognized as fundamental toward protein turnover in eukaryotic cells. The system comprises the ubiquitin conjugation machinery consisting of an enzyme cascade of E1, E2, and E3 enzymes, the deubiquitinases (DUBs) and the proteasome, a multisubunit protease complex acti... |
The Application of Eight-Segment Pulmonary Rehabilitation Exercise in People With Coronavirus Disease 2019 | |
What’s new in lung ultrasound during the COVID-19 pandemic | |
Ramipril in High Risk Patients with COVID-19 | Abstract Background The coronavirus disease 2019 (COVID-19) is caused by SARS-CoV2 that interfaces with the renin-angiotensin-aldosterone system (RAAS) through angiotensin-converting enzyme 2 (ACE-2). This interaction has been proposed as a potential risk factor in patients treated with RAAS-inhibitors. Objectives To a... |
Using iCn3D and the World Wide Web for structure-based collaborative research: Analyzing molecular interactions at the root of COVID-19 | The COVID-19 pandemic took us ill-prepared and tackling the many challenges it poses in a timely manner requires world-wide collaboration. Our ability to study the SARS-COV-2 virus and its interactions with its human host in molecular terms efficiently and collaboratively becomes indispensable and mission-critical in t... |
Melatonin and viral infections | Abstract: The therapeutic effects of melatonin against viral infections, with emphasis on the Venezuelan equine encephalomyelitis (VEE), are reviewed. Melatonin has been shown to prevent paralysis and death in mice infected with the encephalomyocarditis virus and to decrease viremia. Melatonin also postpones the onset ... |
Virus detectives seek source of SARS in China's wild animals | |
The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus | Based on the announcement of the World Health Organization (WHO) in 2018, the Wuhan pneumonia caused by an unknown etiology should be recognized as the first Disease X. Later, the pathogen was identified to be a novel coronavirus denoted 2019-nCoV, which has 79.5% and 96% whole genome sequence identify to SARS-CoV and ... |
Evidence for swine and human papillomavirus in pig slurry in Italy | AIMS: The diversity and the geographical distribution of swine papillomaviruses (PVs) are virtually unknown. The occurrence and the diversity of swine PV were therefore investigated in pig slurry collected in Italy, to contribute towards filling this gap in knowledge. METHODS AND RESULTS: Twenty‐two slurry samples unde... |
#Med StudentCovid – How social media is supporting students during COVID‐19 | COVID‐19 has disrupted medical education on an international scale with clinical attachments cancelled, assessments and teaching moved online, and numerous universities graduating their final year medical students early to assist pressured health systems. As a result, several innovative educational projects and volunte... |
A new chitin-binding lectin from rhizome of Setcreasea purpurea with antifungal, antiviral and apoptosis-inducing activities | Abstract A 48kDa, chitin-binding lectin with antifungal, antiviral and apoptosis-inducing activities was isolated from the rhizomes of Setcreasea purpurea Boom, a member of family Commelinaceae. Setcreasea purpurea lectin (designated as SPL) is a homotetrameric protein consisting of 12031.9Da subunits linked by non-cov... |
Is Mycobacterium paratuberculosis or any other infectious agent involved in the pathogenesis of IBD? | |
Clinical Characteristics of Hematological Patients Concomitant with COVID‐19 | The rapid spread of COVID‐19 represented the most serious issue to public health globally. Hematological patients as immunocompromised hosts are vulnerable to SARS‐CoV‐2 infection. There is rare information available regarding the clinical features of hematological patients concomitant with COVID‐19. In this study, 9 c... |
Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action? | This review summarizes evidence that commercially available fluoroquinolones used for the treatment of bacterial infections are active against other non-bacterial infectious agents as well. Any of these fluoroquinolones exerts, in parallel to its antibacterial action, antiviral, antifungal, and antiparasitic actions at... |
National Library of Medicine Disaster Information Management Research Center: Achieving the vision, 2010–2013 | From 2010 to 2013, the National Library of Medicine (NLM) Disaster Information Management Research Center (DIMRC) continued to build its programs and services on the foundation laid in its starting years, 2008–2010. Prior to 2008, NLM had a long history of providing health information, training, and tools in response t... |
BOARD-INVITED REVIEW: Recent advances in management of highly stressed, newly received feedlot cattle | Morbidity and mortality from bovine respiratory disease (BRD) and associated losses in performance and carcass merit continue to plague the beef cattle industry. Several viral/bacterial agents are responsible for BRD, and interactions occur among the agents. Viral agents often predispose animals to bacterial infections... |
Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation | Data on postoperative chylous ascites (CA) after pediatric liver transplantation (LT) are scarce. This retrospective study was conducted to identify the incidence, risk factors, management, and outcomes of postoperative CA in a large single‐center pediatric LT cohort (2000‐2016). The study cohort comprised 317 LTs (153... |
Supporting the Education of Nurse Practitioners and Physician Assistants in Meeting Shortages in Mental Health Care | |
Constitutional Flavonoids Derived from Epimedium Dose-Dependently Reduce Incidence of Steroid-Associated Osteonecrosis Not via Direct Action by Themselves on Potential Cellular Targets | Intravascular-thrombosis and extravascular-lipid-deposit are the two key pathogenic events considered to interrupt intraosseous blood supply during development of steroid-associated osteonecrosis (ON). However, there are no clinically employed agents capable of simultaneously targeting these two key pathogenic events. ... |
Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what's important? | Pre-existing immunity against human adenovirus (HAd) serotype 5 derived vector in the human population is widespread, thus hampering its clinical use. Various components of the immune system, including neutralizing antibodies (nAbs), Ad specific T cells and type I IFN activated NK cells, contribute to dampening the eff... |
Influenza Vaccination in Type 2 Diabetes Patients: Coverage Status and Its Determinants in Southwestern Saudi Arabia | Despite the significant role of seasonal influenza vaccination in preventing and minimizing the serious complications of influenza infection in type 2 diabetes mellitus (T2DM) patients, unsatisfactory compliance still exists for vaccination. Study objectives were to explore the vaccination status and determinants in T2... |
Adenovirus respiratory infection in hospitalized children in Hong Kong: serotype–clinical syndrome association and risk factors for lower respiratory tract infection | Lower respiratory tract infections (LRTI) caused by adenovirus can be severe with resultant chronic pulmonary sequelae. More than 50 serotypes have been recognized; however, the exact association of serotype with clinical phenotype is still unclear. There have been no reports on the adenovirus serotype pattern in Hong ... |
How COVID-19 Deepens Child Oral Health Inequities | ABSTRACT The fallout from COVID-19 will reveal the depth and range of social, economic, and political disparities faced by U.S. families and children. Those same injustices, magnified and worsened by COVID-19, are also responsible for perpetuating child oral health disparities. |
COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran | The coronavirus disease 2019 (COVID-19) has currently caused a global health threat. Ophthalmic care settings pose a risk of cross-infection. The preventive strategy regarding ophthalmic practice in response to the outbreak is discussed. This is the first report form a tertiary eye hospital in Iran and second of its ki... |
Severe acute respiratory symptoms and severe acute respiratory syndrome | |
Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination | Genetic recombination in single-strand, positive-sense RNA viruses is a poorly understand mechanism responsible for generating extensive genetic change and novel phenotypes. By moving a critical cis-acting replication element (CRE) from the polyprotein coding region to the 3′ non-coding region we have further developed... |
Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective | The universal second messenger cAMP regulates diverse intracellular processes by interacting with ubiquitously expressed proteins, such as Protein Kinase A (PKA) and the Exchange Protein directly Activated by cAMP (EPAC). EPAC is implicated in multiple pathologies, thus several EPAC-specific inhibitors have been identi... |
Operational efficiency of Asia–Pacific airports | Abstract Airports are important drivers of economic development and thus under tremendous pressure from emerging competitors. However, few studies have analysed the operational efficiency of Asia–Pacific airports. This study therefore evaluated the operational efficiency of 21 Asia–Pacific airports between 2002 and 201... |
Radiotherapy for pain relief from bone metastases during Coronavirus (COVID‐19) pandemic | The worldwide pandemic of coronavirus disease (COVID-19) has drammatically and rapidly spread in Italy the last month. By now, nevertheless Italian government efforts to contain the outbreak with escalating restrictive measures, 205463 cases were confirmed, with 27967 deaths. |
The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development | OBJECTIVES AND DESIGN: Developing an effective HIV-1 vaccine that elicits broadly neutralizing HIV-1 human antibodies (bnAbs) remains a challenging goal. Extensive studies on HIV-1 have revealed various strategies employed by the virus to escape host immune surveillance. Here, we investigated the human antibody gene re... |
MHV-JHM infection in immortalized murine oligodendrocytes | |
The landscape of cognitive function in recovered COVID-19 patients | This study aims to evaluate the impacts of COVID-19 on cognitive functions in recovered patients and its relationship with inflammatory profiles. Twenty-nine patients recovered from COVID-19 as confirmed by negative nucleic tests for two consecutive times were recruited. A total of 29 age-, gender- and education-matche... |
Chapter 22 Environmentally Transmitted Pathogens | This chapter describes a variety of pathogens found in the environment that are capable of infecting humans and causing disease. Different classes of pathogens are discussed including bacteria, parasites and viruses. For each pathogen, data are provided on the incidence of the organism in a particular environmental mat... |
COVID-19: Shades of Grey | |
Ischaemic Stroke in the Time of Coronavirus Disease 2019 | Each year, between 1.1 and 1.5 million Europeans have a stroke(1). Two to three out of 10 patients die as a consequence of it and about one third remains functionally dependent(2). As we know, the likelihood of a favourable outcome in this disease relies heavily on patients presenting promptly after symptoms onset and ... |
Homology modeling and virtual screening for antagonists of protease from yellow head virus | Yellow head virus (YHV) is one of the causative agents of shrimp viral disease. The prevention of YHV infection in shrimp has been developed by various methods, but it is still insufficient to protect the mass mortality in shrimp. New approaches for the antiviral drug development for viral infection have been focused o... |
L’ennemi invisible | |
Infections and foreign bodies in the ear, nose and throat | Infections of the ear, nose and throat are common and may threaten life. Intracranial complications may arise from infections of the ear and paranasal sinuses. Orbital complications (loss of vision) may arise from infection of the paranasal sinus. Respiratory embarrassment may result from infections of the upper aerodi... |
Erfolglose Eilanträge im Zusammenhang mit der Corona-Pandemie : BVerfGG §§32 Abs. 1 i.V. mit 93d Abs. 2 | Der Antrag auf Erlass einer einstweiligen Anordnung gegen die bayerische Verordnung über Ausgangsbeschränkungen anlässlich der Corona-Pandemie ist angesichts der überragenden Bedeutung von Leib und Leben abzulehnen – Folgenabwägung |
Vaccines, emerging viruses, and how to avoid disaster | Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic ... |
COVID-19 and conflict: The devastating impact of withdrawing humanitarian support on universal health coverage in Yemen | Abstract The authors warn that, in the context of Yemen, the closure of humanitarian lifesaving programmes and shifting support toward health security, i.e. to support COVID-19 response, at the expense of primary health care support, will undermine existing health system strengthening efforts, worsen the humanitarian c... |
COVID‐19 infection in pancreas transplant recipients | Coronavirus Disease 2019 (COVID‐19) has become a pandemic since first being described in January 2020. Clinical manifestations in non‐transplant patients range from asymptomatic infection to severe pneumonia with acute respiratory distress syndrome, multiorgan system failure and death. Limited reports in kidney transpl... |
Mayo Clinic Strategies for COVID-19 Precautions, Utilization of Personal Protective Equipment, and Conservation Strategies During the COVID-19 Pandemic | |
Response to "Dose Rationale for Favipiravir Use in Patients Infected With SARS‐CoV‐2" | We appreciate the letter by Eloy P., et al for their comments and complement regarding our review1-2 . Two independent in vitro studies indicated that favipiravir (T-705) inhibited SARS-CoV-2 replication in Vero E6 cells with EC50 values of 61.88 μM (9.4 μg/mL)3 and >100 μM (15.7 μg/mL)4 , respectively. Data from the a... |
Recent advances in pharmacological research on Ecklonia species: a review | The genus Ecklonia (Lessoniaceae, Phaeophyceae), commonly called kelp (brown algae), is abundant on the coasts of Japan and Korea. During the past few decades, Ecklonia species have received tremendous attention for their wide range of therapeutic properties and multiple health benefits, such as great nutritional value... |
Do checkpoint inhibitors compromise the cancer patients’ immunity and increase the vulnerability to COVID-19 infection? | The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has been declared a pandemic by the WHO that claimed the lives of thousands of people within a few months. Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. Immune checkpoint inhibi... |
Complete genome sequence of an astrovirus identified in a domestic rabbit (Oryctolagus cuniculus) with gastroenteritis | A colony of domestic rabbits in Tennessee, USA, experienced a high-mortality (~90%) outbreak of enterocolitis. The clinical characteristics were one to six days of lethargy, bloating, and diarrhea, followed by death. Heavy intestinal coccidial load was a consistent finding as was mucoid enteropathy with cecal impaction... |
Safe Hospital Preparedness in the Era of COVID-19: The Swiss Cheese Model | Abstract Since the first emergence in December 2019, COVID-19 rapidly spread out worldwide. During the pandemic of an emerging infectious disease, it is very important to prevent nosocomial outbreak and operate hospitals safely to maintain their functions. In this article, we presented the strategies for safe hospital ... |
New causes and treatments for infectious diarrhea in children | Infectious diarrhea is a universal and important health problem in the pediatric population. An expanding number of potential viral, bacterial, and parasitic pathogens have been associated with diarrheal disease. However, the epidemiologic association of a microorganism with diarrhea is only one step in the process of ... |
Risk factors for the evolutionary emergence of pathogens | Recent outbreaks of novel infectious diseases (e.g. SARS, influenza H1N1) have highlighted the threat of cross-species pathogen transmission. When first introduced to a population, a pathogen is often poorly adapted to its new host and must evolve in order to escape extinction. Theoretical arguments and empirical studi... |
Diseases, Emerging and Infectious | Abstract Emerging and infectious diseases have persisted as leading causes of global morbidity and mortality. Caused by pathogens including bacteria, viruses, parasites, or fungi, they are known to pose serious health threats to the world's population dating back to ancient Egypt. In the 14th Century alone, infectious ... |
Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus | Summary Nitazoxanide is a broad-spectrum antiviral agent undergoing clinical development for treatment of influenza and other viral respiratory infections. Nitazoxanide exhibits in vitro activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and other coronaviruses, inhibiting expression of the viral ... |
15 An overview of automated room disinfection systems: When to use them and how to choose them | Abstract Conventional disinfection methods are limited by reliance on the operator to ensure appropriate selection, formulation, distribution, and contact time of the agent. Automated room disinfection (ARD) systems remove or reduce reliance on operators and so they have the potential to improve the efficacy of termina... |
Quantitative sense-specific determination of murine coronavirus RNA by reverse transcription polymerase chain reaction | Abstract In many applications, it is useful to know the sense and amount of viral RNAs present in a sample. In theory, sense-specific measurement of viral RNAs may be achieved by reverse transcription polymerase chain reaction (RT-PCR) assays which utilize primers of defined polarity during the RT step. However, in pra... |
First introduction of pandemic influenza A/H1N1 and detection of respiratory viruses in pediatric patients in Central African Republic | BACKGROUND: Acute viral respiratory illnesses in children in sub-Saharan Africa have received relatively little attention, although they are much more frequent causes of morbidity and mortality than in developed countries. Active surveillance is essential to identify the causative agents and to improve clinical managem... |
Artificial Intelligence in Modern Medicine – The Evolving Necessity of the Present and Role in Transforming the Future of Medical Care | The dexterity of computer systems to resemble and mimic human intelligence is artificial intelligence. Artificial intelligence has reformed the diagnostic and therapeutic precision and competence in various fields of medicine. Artificial intelligence appears to play a bright role in medical diagnosis. Computer systems ... |
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