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Respiratory variation in central venous pressure (CVP) to guide ventilatory support in COVID-19-related lung injury | |
The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China | The outbreak of 2019 novel coronavirus (COVID‐19) infection emerged in Wuhan, China, in December 2019. Since then the novel coronavirus pneumonia disease has been spreading quickly and many countries and territories have been affected, with major outbreaks in China, South Korea, Italy, and Iran. Influenza virus has bee... |
Analysis of codon usage in type 1 and the new genotypes of duck hepatitis virus | Abstract In this study, an abundant (A+U)% and low codon bias were revealed in duck hepatitis virus type 1 (DHV-1) and the new serotype strains isolated from Taiwan, South Korea and Mainland China (DHV-N). The general correlation between base composition and codon usage bias suggests that mutational pressure rather tha... |
Apartment complex holds clues to pandemic potential of SARS | |
Activity-Based Ubiquitin Probes for Investigation of Deubiquitinases | Abstract Ubiquitination is emerging as an important post-translational modification (PTM) for numerous cellular functions including protein degradation, DNA damage repair and tolerance, and cell cycle progression. Compared with other small-molecule modifiers found in phosphorylation, acetylation and glycosylation, ubiq... |
Home Health Services in the Time of COVID-19: Recommendations for Safe Transitions | Brief Summary: We describe challenges in providing HH services in the time of COVID-19 and present recommendations to improve transitional care and the safety of older adults, families, and HH providers. |
The importance of preventing COVID‐19 in surgical wards cannot be overemphasized | |
Chapter 21 Nanofiltration technology for removal of pathogens present in drinking water | Abstract Water is one of the most important natural resources supporting the diverse array of life present on earth. Rapid diminution of fresh potable water reserves, contamination of existing ones, and generation of large amount of wastewater due to anthropogenic activities have compelled the scientists to develop met... |
George Fu Gao: the past and future of Ebola | Newly returned from the frontline of the battle against Ebola in West Africa, Dr George Fu Gao talked to NSR on this largest Ebola epidemic in history. As Deputy Director-General of the Chinese Center for Disease Control and Prevention (China CDC), an Academician of the Chinese Academy of Sciences and a fellow of the T... |
Epidemiology, Molecular Epidemiology and Evolution of Bovine Respiratory Syncytial Virus | The bovine respiratory syncytial virus (BRSV) is an enveloped, negative sense, single-stranded RNA virus belonging to the pneumovirus genus within the family Paramyxoviridae. BRSV has been recognized as a major cause of respiratory disease in young calves since the early 1970s. The analysis of BRSV infection was origin... |
What Caused the Outbreak of COVID-19 in China: From the Perspective of Crisis Management | Since the first known case of a COVID-19 infected patient in Wuhan, China on 8 December 2019, COVID-19 has spread to more than 200 countries, causing a worldwide public health crisis. The existing literature fails to examine what caused this sudden outbreak from a crisis management perspective. This article attempts to... |
COVID‐19 and nonalcoholic fatty liver disease: two intersecting pandemics | BACKGROUND: Initial evidence from China suggests that most vulnerable subjects to COVID‐19 infection suffer from pre‐existing illness, including metabolic abnormalities. The pandemic characteristics and high‐lethality rate of COVID‐19 infection have raised concerns about interactions between virus pathobiology and comp... |
Surgical Volunteerism | |
Survey of Slaughtered Pigs for Occurrence of Ochratoxin A and Porcine Nephropathy in Serbia | Samples of blood, kidney and liver were randomly selected from slaughtered pigs (n=90) and analyzed for ochratoxin A by HPLC. In addition, in order to obtain information on the occurrence of nephropathy, histological examinations were carried out. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22–14.5 n... |
Arbeitsbedingte Infektionen bei Mitarbeitern des Gesundheitswesens: Respiratorische Erkrankungen | INTRODUCTION: In some medical departments, healthcare workers (HCWs) are at risk for aerogene transmitted infectious diseases. Numerous fatal causalities were described in the international environment. For example fatal causalities during the SARS-Epidemic as well as cases of death caused by influenza. METHODS AND RES... |
Preparedness and Preventive Behaviors for a Pandemic Disaster Caused by COVID-19 in Serbia | Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. The disease was first detected in Wuhan, the capital of China’s Hubei province, in December 2019 and has since spread globally, especially to Europe and North America, resulting in the ongoing global ... |
Approaches to Daily Monitoring of the SARS-CoV-2 Outbreak in Northern Italy | Italy was the first European country affected by the Sars-Cov-2 pandemic, with the first autochthonous case identified on Feb 21st. Specific control measures restricting social contacts were introduced by the Italian government starting from the beginning of March. In the current study we analyzed public data from the ... |
Prevalence and Mortality of COVID-19 patients with Gastrointestinal Symptoms: A Systematic Review and Meta-analysis | Abstract Objectives To perform a systematic review and meta-analysis evaluating the prevalence of gastrointestinal (GI) symptoms and mortality in patients diagnosed with coronavirus disease 2019 (COVID-19). Methods A systematic search of MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database... |
The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1 | The nucleocapsid (N) protein of SARS coronavirus (SARS_CoV) is a major structural component of virions, which appears to be a multifunctional protein involved in viral RNA replication and translation. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is related to the pre-mRNA splicing in the nucleus and translatio... |
Publishing in the time of the coronavirus pandemic | |
Design of synthetic peptides for oral vaccination | Abstract The rational design of effective oral vaccines based on synthetic peptides is a very ambitious undertaking, and involves the solution of huge problems related to protection of the antigens against degradation in the alimentary tract, efficient uptake of the antigens by the relevant cells, and efficient inducti... |
Inhibition of porcine transmissible gastroenteritis virus infection in porcine kidney cells using short hairpin RNAs targeting the membrane gene | The membrane (M) protein is the most abundant component of the porcine transmissible gastroenteritis virus (TGEV) particle. To exploit the possibility of using RNA interference (RNAi) as a strategy against TGEV infection, three plasmids (pRNAT-1, pRNAT-2, and pRNAT-3) expressing short hairpin RNAs were designed to targ... |
Clinical and biological data on the use of hydroxychloroquine against SARS‐CoV‐2 could support the role of the NLRP3 inflammasome in the pathogenesis of respiratory disease | The use of hydroxychloroquine (HCL) has been very common in countries with a rapid spread of coronavirus disease 2019 (COVID-19), although controversial and the subject of heated scientific discussions with implications for the whole society. This article is protected by copyright. All rights reserved. |
Sentinel-based Surveillance of Coyotes to Detect Bovine Tuberculosis, Michigan | Bovine tuberculosis (TB) is endemic in white-tailed deer (Odocoileus virginianus) in the northeastern portion of Michigan’s Lower Peninsula. Bovine TB in deer and cattle has created immense financial consequences for the livestock industry and hunting public. Surveillance identified coyotes (Canis latrans) as potential... |
Equivalence of Self- and Staff-Collected Nasal Swabs for the Detection of Viral Respiratory Pathogens | BACKGROUND: The need for the timely collection of diagnostic biosamples during symptomatic episodes represents a major obstacle to large-scale studies on acute respiratory infection (ARI) epidemiology. This may be circumvented by having the participants collect their own nasal swabs. We compared self- and staff-collect... |
Hemodynamics, baroreflex index and blood biomarkers of a patient who died after being affected by covid-19: case report | |
What have we learned from animal models of ventilator-induced lung injury? | |
Selection of reference genes for the quantitative real-time PCR normalization of gene expression in Isatis indigotica fortune | BACKGROUND: Isatis indigotica, a traditional Chinese medicine, produces a variety of active ingredients. However, little is known about the key genes and corresponding expression profiling involved in the biosynthesis pathways of these ingredients. Quantitative real-time polymerase chain reaction (qRT-PCR) is a powerfu... |
Investigation on the co-infections of Toxoplasma gondii with PRRSV, CSFV or PCV-2 in swine in part of China | Abstract The objective of the present investigation was to estimate the prevalence of Toxoplasma gondii infection and co-infection with porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV-2) in pigs in China. A total of 372 tissues or serum ... |
A Generic Quantitative Risk Assessment Framework for the Entry of Bat-Borne Zoonotic Viruses into the European Union | Bat-borne viruses have been linked to a number of zoonotic diseases; in 2014 there have been human cases of Nipah virus (NiV) in Bangladesh and Ebola virus in West and Central Africa. Here we describe a model designed to provide initial quantitative predictions of the risk of entry of such viruses to European Union (EU... |
Analysis of the N Protein in Feline Coronavirus Strains in Italy | |
Onward transmission of viruses: how do viruses emerge to cause epidemics after spillover? | The critical step in the emergence of a new epidemic or pandemic viral pathogen occurs after it infects the initial spillover host and then is successfully transmitted onwards, causing an outbreak chain of transmission within that new host population. Crossing these choke points sets a pathogen on the pathway to epidem... |
Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential | Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secreted by MSCs derived from different sources that contain therapeutic molecules such as RNA and proteins, which ... |
Ribavirin: a drug active against many viruses with multiple effects on virus replication and propagation. Molecular basis of ribavirin resistance | Ribavirin has proven to be effective against several viruses in the clinical setting and a multitude of viruses in vitro. With up to five different proposed mechanisms of action, recent advances have begun to discern the hierarchy of antiviral effects at play depending on the virus and the host conditions under scrutin... |
El papel de las mascarillas en el control de la epidemia Covid-19 | |
Interferon-Stimulated Gene 15 Conjugation Stimulates Hepatitis B Virus Production Independent of Type I Interferon Signaling Pathway In Vitro | Hepatitis B virus (HBV) is an important account of infectious hepatitis and interferon (IFN) remains one of the best treatment options. Activation of type I IFN signaling pathway leads to expressions of IFN-stimulated genes (ISGs) which play important roles in antiviral and immunomodulatory responses to HBV or hepatiti... |
COVID-19 stay-at-home order in Tyrol, Austria: Sport and exercise behaviour in change? | Abstract Objectives The aim of the study was to investigate differences in the frequency and types of engagement in sport before, during, and after the COVID-19 stay-at-home order in Tyrol, Austria. Study design A representative population survey was conducted. Methods A sample of Tyroleans (N = 511) were questioned by... |
Effects of 3-Dimensional Lumbar Stabilization Training for Balance in Chronic Hemiplegic Stroke Patients: A Randomized Controlled Trial | OBJECTIVE: To investigate the effects of the newly developed Spine Balance 3D system on the balance and gait abilities of hemiplegic stroke patients. METHODS: Twenty-eight hemiplegic patients with chronic stroke were randomly assigned to an experimental (n=14) or control group (n=14). The experimental and control group... |
A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial | OBJECTIVES: SARS-CoV2 infection leads to a concomitant pulmonary inflammation. This inflammation is supposed to be the main driver in the pathogenesis of lung failure (Acute Respiratory Distress Syndrome) in COVID-19. Objective of this study is to evaluate the efficacy and safety of a single dose treatment with Tociliz... |
Vaccine Development Against Middle East Respiratory Syndrome | Various types of vaccines are under pre-clinical and clinical development to address the recent appearance of Middle East respiratory syndrome or MERS, an emerging infectious disease that has already caused over 600 deaths and remains a threat to world health. The causative agent for this respiratory disease is a membe... |
2019 novel coronavirus is undergoing active recombination | |
Use of glucocorticoids in patients with acute respiratory distress syndrome: a meta-analysis and trial sequential analysis | BACKGROUND: Acute respiratory distress syndrome (ARDS) is a common and disabling disease with high rates of mortality and morbidity. The role of steroids in treating ARDS remains controversial. We aim to examine the evidence behind using glucocorticoids in the management of ARDS from the available studies. METHODS: We ... |
Psychophysical tests reveal impaired olfaction but preserved gustation in COVID‐19 patients | |
Impact of coronavirus disease 2019 (COVID-19) emergency on Italian radiologists: a national survey | OBJECTIVES: To perform an online survey aimed at evaluating the impact of COVID-19 on Italian radiology departments. METHODS: We launched a survey composed of 25 questions about how COVID-19 has changed the safety and organization of daily activity in Italian radiology units. RESULTS: A total of 2136/10,564 (20.2%) rad... |
Genetic Diversity and Phylodynamics of Avian Coronaviruses in Egyptian Wild Birds | Avian coronaviruses (ACoVs) are continuously evolving and causing serious economic consequences in the poultry industry and around the globe. Owing to their extensive genetic diversity and high mutation rates, controlling ACoVs has become a challenge. In this context, the potential contribution of wild birds in the dis... |
Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature | We report a rare case of adenoviral pneumonia in a previously healthy pregnant woman at 26(+4) weeks' gestation. She presented with persistent high fever, cough for 5 days, and developed progressive dyspnea with hypoxemic respiratory failure and bilateral pulmonary infiltrates with pleural effusions. Aggressive support... |
Community-acquired polymicrobial pneumonia in the intensive care unit: aetiology and prognosis | INTRODUCTION: The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. The aim of the present study was to describe the prevalence, clinical characteristics and outcomes of severe CAP of polymicrobial aetiology in pat... |
The expanded development and application of CRISPR system for sensitive nucleotide detection | |
Chapter 57 Respiratory Diseases | |
Pneumonia among Travelers Returning from Abroad | BACKGROUND: Although respiratory tract infections represent a frequent cause of morbidity in travelers, and pneumonia a frequent cause of medical consultation among febrile travelers returning home, the etiologic spectrum of pneumonia in travelers has not been specifically studied. METHODS: We reviewed the medical char... |
Editorial overview: Anti-infectives | |
A systematic review on the causes of the transmission and control measures of outbreaks in long-term care facilities: Back to basics of infection control | BACKGROUND: The unique characteristics of long-term care facilities (LTCFs) including host factors and living conditions contribute to the spread of contagious pathogens. Control measures are essential to interrupt the transmission and to manage outbreaks effectively. AIM: The aim of this systematic review was to verif... |
Use of the recombinant nonstructural 3A, 3B, and 3AB proteins of foot-and-mouth disease virus in indirect ELISA for differentiation of vaccinated and infected cattle | Recombinant foot-and-mouth disease virus (FMDV) proteins 3A, 3B, and 3AB were produced by expressing the corresponding genes in Escherichia coli and purified by metal-chelate affinity chromatography. The recombinant proteins were used as antigens in indirect enzyme-linked immunosorbent assay (ELISA) to differentiate be... |
A comprehensive collection of systems biology data characterizing the host response to viral infection | The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vit... |
COVID-19: how to make between-country comparisons | BACKGROUND: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. We propose methods to allow a direct comparison and we present the results of this comparison. DESIGN: Publicl... |
Novel semi-metrics for multivariate change point analysis and anomaly detection | This paper proposes a new method for determining similarity and anomalies between time series, most practically effective in large collections of (likely related) time series, by measuring distances between structural breaks within such a collection. We introduce a class of semi-metric distance measures, which we term ... |
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice | Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID-19, which is currently a major global concern. Thymoquinone (TQ) is one of the most active ingredients in Nigella sativa seeds. It has a variety of beneficial prope... |
Significance of Coronavirus Mutants in Feces and Diseased Tissues of Cats Suffering from Feline Infectious Peritonitis | The internal FECV→FIPV mutation theory and three of its correlates were tested in four sibs/half-sib kittens, a healthy contact cat, and in four unrelated cats that died of FIP at geographically disparate regions. Coronavirus from feces and extraintestinal FIP lesions from the same cat were always >99% related in acces... |
Mobile health clinic model in the COVID-19 pandemic: lessons learned and opportunities for policy changes and innovation | BACKGROUND: Mobile Clinics represent an untapped resource for our healthcare system. The COVID-19 pandemic has exacerbated its limitations. Mobile health clinic programs in the US already play important, albeit under-appreciated roles in the healthcare system. They provide access to healthcare especially for displaced ... |
Is China prepared for microbial threats? | There is no bigger acute microbial threat to China, and to the rest of the world, than an influenza pandemic, and no better time to prepare for this eventuality than now. David Ho asks what more China could be doing. |
Mala Murthy | Interview with Mala Murthy, who studies the neural mechanisms underlying social communication in Drosophila at the Princeton Neuroscience Institute at Princeton University. |
COVID-19 Pandemic: a Litmus Test of Trust in the Health System | The pandemic caused by the SARS-CoV2 novel coronavirus is creating a global crisis. There is a global ambience of uncertainty and anxiety. In addition, nations have imposed strict and restrictive public health measures including lockdowns. In this heightened time of vulnerability, public cooperation to preventive measu... |
Possible Role of Adipose Tissue and Endocannabinoid System in COVID‐19 Pathogenesis: Can Rimonabant Return? | This is the main conclusion of a recent study describing a strong relationship between the degree of obesity and the severity of COVID‐19 infection. Obesity has various negative consequences relative to the course of COVID‐19, including adverse effects on lung physiology, and induces comorbidities such as type II diabe... |
SARS‐CoV‐2: what is known and what there is to know. Focus on coagulation and lipids | As the SARS‐CoV2 pandemic is still progressing, dissemination of information has become of paramount importance. However, the rapid influx of SARS‐CoV‐2 patients in our hospitals has overwhelmed the time needed for appropriate information interpretation and its application. Noteworthy, awareness among clinicians is gro... |
COVID-19 Mimicking Dengue Fever with the Initial Manifestation of Retro-orbital Pain – a Rare Case | |
Bulk production of the antiviral lectin griffithsin | Application of plant‐based protein expression systems for bulk production of recombinant protein pharmaceuticals is building momentum. There are considerable regulatory challenges to consider in commercialization of plant‐made pharmaceuticals (PMPs), some of which are inherent to plant‐production systems and others tha... |
What can we learn from China’s health system reform? | Qingyue Meng and colleagues assess what China’s health system reform has achieved and what needs to be done over the next decade |
Prospective case-control analysis of the aetiologies of acute undifferentiated fever in Vietnam | Acute undifferentiated fever (AUF) is frequently observed in tropical settings, but diagnosing the cause of AUF is often a challenge for local physicians and the physicians treating returning travellers. We conducted a case-control study in central Vietnam in 2016. A total of 378 febrile adult patients (AUFs) with a fe... |
Reply to “Potential challenges in managing obstetric patients with COVID-19” | |
Tomar medidas preventivas inmediatamente: evidencia de China sobre el COVID-19 | |
RNA binding properties of core protein of the flavivirus Kunjin | Kunjin virus (KUN) C is a typical flavivirus core protein which is truncated in vivo to a mature form of 105 residues enriched in lysine and arginine. In order to study the possible association of KUN C with RNA in vitro, we prepared several recombinant C proteins with specific deletions, each fused at the amino-termin... |
Unconscious Bias, Racism, and Trauma-Informed Policing: an Address and Message to the Connecticut Racial Profiling Prohibition Project Advisory Board | As a community member of the Connecticut Racial Profiling Prohibition Project Advisory Board, I wish to acknowledge the group for its work, but to make clear there is much more to be done. While the state’s data show more parity across departments, we know that unconscious bias and racism still exists. I wish to advoca... |
Cleavage and Serum Reactivity of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein | Severe acute respiratory syndrome (SARS) coronavirus (SCoV) spike (S) protein is the major surface antigen of the virus and is responsible for receptor binding and the generation of neutralizing antibody. To investigate SCoV S protein, full-length and individual domains of S protein were expressed on the surface of ins... |
Current status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticles | Many studies are currently investigating the development of safe and effective vaccines to prevent various infectious diseases. Multiple antigen-presenting peptide vaccine systems have been developed to avoid the adverse effects associated with conventional vaccines (i.e., live-attenuated, killed or inactivated pathoge... |
Respiratory Tract Viral Infections and Coinfections Identified by Anyplex™ II RV16 Detection Kit in Pediatric Patients at a Riyadh Tertiary Care Hospital | Respiratory infections are caused by an array of viruses, and limited information is available about viral coexistence, comparative symptoms, and the burden of illness. This retrospective cohort study aimed to determine the etiological agents responsible for respiratory tract infections by Anyplex II RV16 detection kit... |
La sécurité sanitaire mondiale à l’heure de Nagoya | SUMMMARY The International Health Regulations are the main legal instrument to prevent the international propagation of diseases, particularly related to infectious agents. It supports the exchange of samples between countries. These exchanges have raised expectations, in many countries, about the sharing of the benefi... |
Coronavirus-like particles in the feces of normal cats | Coronavirus-like particles, morphologically indistinguishable from coronavirus-like particles seen in human, canine, and simian feces, were detected by electron microscopy in the feces from both feline infectious peritonitis antibody-positive and antibody-negative cats. |
The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection | Abstract The intrasplenic injection of human peripheral blood mononuclear cells (PBMCs) into severely immune deficient NOD/SCID mice, causes a massive and transient dominant expansion of human B cells in the spleen. This permits the easy isolation of human monoclonal antibodies specific for different antigens by a Kohl... |
An overview of the highly pathogenic H5N1 influenza virus | Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenge... |
Infectious diseases in healthcare workers – an analysis of the standardised data set of a German compensation board | INTRODUCTION: Healthcare workers (HCW) are exposed to infectious agents. Disease surveillance is therefore needed in order to foster prevention. METHODS: The data of the compensation board that covers HCWs of non-governmental healthcare providers in Germany was analysed for a five-year period. For hepatitis B virus (HB... |
Analysis of clinical information and reverse transcriptase-polymerase chain reaction for early diagnosis of enteroviral meningitis | PURPOSE: Meningitis is among the most common infections affecting the central nervous system. It can be difficult to determine the exact pathogen responsible for the infection and patients are often treated with empiric antibiotics. This study was conducted to identify the most common clinical characteristics of entero... |
Monoclonal antibodies for the S2 subunit of spike of SARS-CoV cross-react with the newly-emerged SARS-CoV-2 | The emergence of a novel coronavirus, SARS-CoV-2, at the end of 2019 has resulted in widespread human infections across the globe. While genetically distinct from SARS-CoV, the etiological agent that caused an outbreak of severe acute respiratory syndrome (SARS) in 2003, both coronaviruses exhibit receptor binding doma... |
Vascular endothelium: the battlefield of dengue viruses | Increased vascular permeability without morphological damage to the capillary endothelium is the cardinal feature of dengue haemorrhagic fever (DHF)/dengue shock syndrome (DSS). Extensive plasma leakage in various tissue spaces and serous cavities of the body, including the pleural, pericardial and peritoneal cavities ... |
Microbial Virulence as an Emergent Property: Consequences and Opportunities | |
Specific, simple and rapid detection of porcine circovirus type 2 using the loop-mediated isothermal amplification method | BACKGROUND: Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome (PMWS), and porcine dermatitis and nephropathy syndrome (PDNS). It has caused heavy losses in global agriculture in recent decades. Rapid detection of PCV2 is very important for the effective prophylaxis an... |
Why must T cells be cross-reactive? | Clonal selection theory proposed that individual T cells are specific for a single peptide–MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast array of potential foreign peptide–MHC complexes, and a comprehensive system requires each T cell to recognize numerous peptides and thus b... |
Alltest rapid lateral flow immunoassays is reliable in diagnosing SARS-CoV-2 infection from 14 days after symptom onset: a prospective single-center study | OBJECTIVES: SARS-CoV-2 infection diagnosis is challenging in patients from 2-3 weeks after the onset of symptoms, due to the low positivity rate of the PCR. Serologic tests could be complementary to PCR in these situations. The aim of our study was to analyze the diagnostic performance of one serologic rapid test in CO... |
Detection of antibodies against porcine epidemic diarrhea virus in serum and colostrum by indirect ELISA | Abstract An indirect porcine epidemic diarrhea virus (PEDV) anti-immunoglobulin (Ig) G ELISA based on the S1 portion of the spike protein was validated and compared with an indirect immunofluorescence assay. In serum samples from experimentally infected pigs (n = 35), anti-IgG PEDV antibodies were detected as early as ... |
The Relationship between Airway Inflammation and Exacerbation in Chronic Obstructive Pulmonary Disease | Chronic obstructive pulmonary disease (COPD) is associated with abnormal inflammatory response and airflow limitation. Acute exacerbation involves increased inflammatory burden leading to worsening respiratory symptoms, including dyspnea and sputum production. Some COPD patients have frequent exacerbations (two or more... |
Edible Vaccines: Promises and Challenges | Vaccines are biological preparations that improve immunity to particular diseases and form an important innovation of 19th century research. It contains a protein that resembles a disease-causing microorganism and is often made from weak or killed forms of the microbe. Vaccines are agents that stimulate the body’s immu... |
Living with HIV in the time of COVID‐19: A glimpse of hope | As at the time of writing, the global confirmed cases of the coronavirus disease (COVID-19) stands at 5,075,181 with 330,981 deaths and 1,936,331 recoveries1 . According to the Canter for Disease Control, the aged and individuals with compromised immune systems due to infections (i.e., human immunodeficiency viruses (H... |
PEER COMPANIONSHIP FOR MENTAL HEALTH OF OLDER ADULTS IN PRIMARY CARE: A PRAGMATIC, NON-BLINDED, PARALLEL-GROUP, RANDOMIZED CONTROLLED TRIAL | OBJECTIVES: To determine whether peer companionship delivered by an aging services agency to socially-disconnected older adult primary care patients was associated with improvement in suicidal ideation depression, anxiety, and psychological connectedness. DESIGN: Pragmatic, non-blinded, parallel-group, randomized contr... |
Neurological Involvement in COVID-19 and Potential Mechanisms: A Review | As the current understanding of COVID-19 continues to evolve, a synthesis of the literature on the neurological impact of this novel virus may help inform clinical management and highlight potentially important avenues of investigation. Additionally, understanding the potential mechanisms of neurologic injury may guide... |
Capturing sequence diversity in metagenomes with comprehensive and scalable probe design | Metagenomic sequencing has the potential to transform microbial detection and characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a computational method to enhance nucleic-acid capture for enrichment of diverse microbial taxa. CATCH designs optimal probe sets, with a specified ... |
Falling down the Rabbit Hole: aTRIP Toward Lexiconic Precision in the “Gain-of-Function” Debate | |
Understanding Human Coronavirus HCoV-NL63 | Even though coronavirus infection of humans is not normally associated with severe diseases, the identification of the coronavirus responsible for the outbreak of severe acute respiratory syndrome showed that highly pathogenic coronaviruses can enter the human population. Shortly thereafter, in Holland in 2004, another... |
A Fatal Case of Coronavirus Disease 2019 (COVID-19) in a Patient With Idiopathic Pulmonary Fibrosis | The number of cases of coronavirus disease 2019 (COVID-19) has been exponentially increasing everyday. It is important to recognize the comorbidities and risk factors associated with this highly contagious and serious disease that has caused thousands of deaths worldwide. Patients with certain conditions like diabetes,... |
Transmissible Gastroenteritis Virus (TGEV) Infection Alters the Expression of Cellular MicroRNA Species That Affect Transcription of TGEV Gene 7 | Transmissible gastroenteritis virus (TGEV) is a member of Coronaviridae family. TGEV infection has emerged as a major cause of severe gastroenteritis and leads to alterations of many cellular processes. Meanwhile, the pathogenic mechanism of TGEV is still unclear. microRNAs (miRNAs) are a novel class of small non-codin... |
CAMBIOS EVOLUTIVOS PULMONARES EN LA ECOGRAFÍA TORÁCICA EN PACIENTES CON COVID-19 | |
COVID-19: The unreasonable effectiveness of simple models | Abstract When the novel coronavirus disease SARS-CoV2 (COVID-19) was officially declared a pandemic by the WHO in March 2020, the scientific community had already braced up in the effort of making sense of the fast-growing wealth of data gathered by national authorities all over the world. However, despite the diversit... |
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