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Conceptual Design of a Body Bag for Preventing Infections and Safe Disposal of Deceased from COVID-19 Virus | The Covid-19 virus pandemic is leading to a large number of deaths. There are forecasts that there will be an exponential increase in the number of such deaths across the globe because of this deadly virus. To arrest the spread of the virus in this situation, the supply of medical materials including PPE and body bags ... |
An age-structured model for coupling within-host and between-host dynamics in environmentally-driven infectious diseases | In this paper, an age-structured epidemic model for coupling within-host and between-host dynamics in environmentally-driven infectious diseases is investigated. The model is described by a mixed system of ordinary and partial differential equations which is constituted by the within-host virus infectious fast time ord... |
SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes | The SARS (severe acute respiratory syndrome) outbreak was caused by a coronavirus (CoV) named the SARS-CoV. SARS pathology is propagated both by direct cytotoxic effects of the virus and aberrant activation of the innate immune response. Here, we identify several mechanisms by which a SARS-CoV open reading frame (ORF) ... |
New clinical and seasonal evidence of infections by Human Parainfluenzavirus | Human Parainfluenzaviruses (PIVs) account for a significant proportion of viral acute respiratory infections (ARIs) in children, and are also associated with morbidity and mortality in adults, including nosocomial infections. This work aims to describe PIV genotypes and their clinical and epidemiological distribution. ... |
Pro/con clinical debate: Isolation precautions for all intensive care unit patients with methicillin-resistant Staphylococcus aureus colonization are essential | Antibiotic-resistant bacteria are an increasingly common problem in intensive care units (ICUs), and they are capable of impacting on patient outcome, the ICU's budget and bed availability. This issue, coupled with recent outbreaks of illnesses that pose a direct risk to ICU staff (such as SARS [severe acute respirator... |
Therapeutic Potential for Tetracyclines in the Treatment of COVID‐19 | Currently there is a race against time to identify prophylactic and therapeutic treatments against COVID-19. Until these treatments are developed, tested and mass produced, it might be prudent to look into existing therapies that could be effective against this virus. Based on the available evidence we believe that tet... |
Identification of a Mimotope Peptide Bound to the SARS-CoV Spike Protein Specific Monoclonal Antibody 2C5 with Phage-displayed Peptide Library | Abstract This article aims to identify the epitope corresponding to SARS-CoV spike protein specific neutralizing monoclonal antibody (MAb) 2C5. The antibody was used as the target and three rounds of bio-panning were conducted with a phage-displayed peptide library. After the third panning, 20 phage-plaque clones were ... |
The Anxiety of Being Asian American: Hate Crimes and Negative Biases During the COVID-19 Pandemic | In this essay, we review how the COVID-19 (coronavirus) pandemic that began in the United States in early 2020 has elevated the risks of Asian Americans to hate crimes and Asian American businesses to vandalism. During the COVID-19 pandemic, the incidents of negative bias and microaggressions against Asian Americans ha... |
Deoxyribozymes and bioinformatics: complementary tools to investigate axon regeneration | For over 100 years, scientists have tried to understand the mechanisms that lead to the axonal growth seen during development or the lack thereof during regeneration failure after spinal cord injury (SCI). Deoxyribozyme technology as a potential therapeutic to treat SCIs or other insults to the brain, combined with a b... |
COVID‐19 and diabetes | |
Development and validation of different indirect ELISAs for MERS-CoV serological testing | Abstract Since 2012, MERS-CoV has caused up to 2220 cases and 790 deaths in 27 countries with Saudi Arabia being the most affected country with ~83.1% of the cases and ~38.8% local death rate. Current serological assays such as microneutralization (MN), plaque reduction neutralization, immunofluorescence, protein micro... |
Estimation of the basic reproduction number, average incubation time, asymptomatic infection rate, and case fatality rate for COVID‐19: Meta‐analysis and sensitivity analysis | The coronavirus disease‐2019 (COVID‐19) has been found to be caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). However, comprehensive knowledge of COVID‐19 remains incomplete and many important features are still unknown. This manuscript conducts a meta‐analysis and a sensitivity study to answ... |
A long overdue ban | In an attempt to stem the spread of coronavirus, China has shut its wildlife markets for good. It is a welcome move, says Adam Vaughan |
Supporting individuals with intellectual and developmental disability during the first 100 days of the COVID‐19 outbreak in the USA | BACKGROUND: It is unknown how the novel Coronavirus SARS‐CoV‐2, the cause of the current acute respiratory illness COVID‐19 pandemic that has infected millions of people, affects people with intellectual and developmental disability (IDD). The aim of this study is to describe how individuals with IDD have been affected... |
Coronavirus antibody positive tests and continued use of personal protective equipment throughout the pandemic | The COVID-19 pandemic has thrust not only a novel virus onto the world, but new challenges resulting in novel approaches. Governments have reduced regulation in order to facilitate timely advances to combat the disease. Antibody testing has rapidly been deployed but it is creating challenges for staff and patients. Mas... |
Society for Advanced Bronchoscopy Consensus Statement and Guidelines for bronchoscopy and airway management amid the COVID-19 pandemic. | |
Efficacy of Face Shields Against Cough Aerosol Droplets from a Cough Simulator | Health care workers are exposed to potentially infectious airborne particles while providing routine care to coughing patients. However, much is not understood about the behavior of these aerosols and the risks they pose. We used a coughing patient simulator and a breathing worker simulator to investigate the exposure ... |
Development of a Multiplex RT-qPCR for the Detection of Different Clades of Avian Influenza in Poultry | Since the initial detection of H5N1, a highly pathogenic avian influenza (HPAI) virus, in 1996 in China, numerous HPAI H5 lineages have been classified, and they continue to pose a threat to animal and human health. In this study, we developed a novel primer/probe set that can be employed to simultaneously detect pan-H... |
Automated Real-Time Collection of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology | BACKGROUND: Health care and public health professionals rely on accurate, real-time monitoring of infectious diseases for outbreak preparedness and response. Early detection of outbreaks is improved by systems that are comprehensive and specific with respect to the pathogen but are rapid in reporting the data. It has p... |
Chapter 5 Respiratory infections of the human bocavirus | Abstract The human bocavirus is one of the most common respiratory viruses and occurs in all age groups. It is associated with upper and lower respiratory tract infections, and causes clinical symptoms from the mild common cold to life threatening respiratory diseases. Besides its ability to persist the virus appears t... |
Rapid and sensitive real-time assay for the detection of respiratory syncytial virus using RT-SIBA® | BACKGROUND: Respiratory syncytial virus (RSV) is one of the most common causes of respiratory tract infections among young children and the elderly. Timely and accurate diagnosis of respiratory tract infections improves patient care and minimizes unnecessary prescriptions of antibiotics. We sought to develop a rapid nu... |
Response to 'Pulmonary thrombosis in 2019‐nCoV pneumonia?' | We appreciate the opportunity to respond to the comments by Dr. Marongiu et al., they presented that as only laboratory findings of Disseminated Intravascular Coagulation (DIC) but no bleeding was mentioned, indicating that there was not an overt DIC in our patients, instead, the abnormal laboratory findings could be a... |
Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum | BACKGROUND: We investigated the potential of proteomic fingerprinting with mass spectrometric serum profiling, coupled with pattern recognition methods, to identify biomarkers that could improve diagnosis of tuberculosis. METHODS: We obtained serum proteomic profiles from patients with active tuberculosis and controls ... |
Cell surface influenza haemagglutinin can mediate infection by other animal viruses. | We have used filter-grown Madin-Darby canine kidney (MDCK) cells to explore the mechanism by which influenza virus facilitates secondary virus infection. Vesicular stomatitis virus (VSV) and Semliki Forest virus (SFV) infect only through the basolateral surface of these polarized epithelial cells and not through the ap... |
Use of Plasma Therapy for Severe Fever with Thrombocytopenia Syndrome Encephalopathy | |
Mental Health, Risk Factors, and Social Media Use During the COVID-19 Epidemic and Cordon Sanitaire Among the Community and Health Professionals in Wuhan, China: Cross-Sectional Survey | BACKGROUND: The mental health consequences of the coronavirus disease (COVID-19) pandemic, community-wide interventions, and social media use during a pandemic are unclear. The first and most draconian interventions have been implemented in Wuhan, China, and these countermeasures have been increasingly deployed by coun... |
A picture of the covid-19 impact on IVIRMA fertility treatment clinics in Spain and Italy | Abstract The emergence of the novel coronavirus infection that arose in Wuhan, China in December 2019 has resulted in an epidemic that has quickly expanded to become one of the most significant public health threats in recent times. Unfortunately, the disease has spread globally. On March 11th (2020) World Health Organ... |
How to Help Our Frontline Warriors in COVID-19 Pandemic: an Initiative by Delhi State Chapter, ASI | |
Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells | Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until six years ago. The Orsay virus and its related nematode viruses have a positive-sense RNA genome, encoding three proteins: CP, RdRP, and a novel δ protein that shares no homolog... |
A social identity perspective on COVID‐19: Health risk is affected by shared group membership | In the face of a novel infectious disease, changing our collective behaviour is critical to saving lives. One determinant of risk perception and risk behaviour that is often overlooked is the degree to which we share psychological group membership with others. We outline, and summarize supporting evidence for, a theore... |
Questionnaire on Perception of Threat from COVID-19 | The ravages caused by the disease known as COVID-19 has led to a worldwide healthcare and social emergency requiring an effective combined effort from everyone to reduce contagion. Under these circumstances, the perception of the disease is going to have a relevant role in the individual’s psychological adjustment. How... |
Personal economic anxiety in response to COVID-19 | The economic effects of COVID-19 have been far-reaching. Using a sample of adults from the United States (n = 513), the present study examined demographic and individual correlates of anxiety about financial hardship on March 17th, 2020, the day after historic stock market drops in response to the emerging COVID-19 cri... |
Specialist paediatric palliative care for children and young people with cancer: A mixed-methods systematic review | BACKGROUND: Specialist paediatric palliative care services are promoted as an important component of palliative care provision, but there is uncertainty about their role for children with cancer. AIM: To examine the impact of specialist paediatric palliative care for children and young people with cancer and explore fa... |
Severe acute respiratory SARS-CoV-2 infection in dialysis patients in northern Italy: a single-centre experience | BACKGROUND: Dialysis patients are considered at high risk for COVID-19 and the infection can easily spread in dialysis units. METHODS: We conducted an observational single-centre cohort study to describe clinical characteristics, treatments and outcomes of dialysis patients with severe acute respiratory syndrome corona... |
Monoclonal antibodies versus reverse transcription‐PCR for detection of respiratory viruses in a patient population with respiratory tract infections admitted to hospital | In the winter season 2001–2002, 239 nasopharyngeal aspirate and 15 bronchoalveolar lavage samples from 208 patients (135 pediatric and 73 adults, including 19 lung transplant recipients) admitted to hospital because of an acute respiratory tract infection were examined for rapid diagnosis of respiratory viruses by two ... |
Lactate dehydrogenase as a marker of nasopharyngeal inflammatory injury during viral upper respiratory infection: implications for acute otitis media | BACKGROUND: Acute otitis media (AOM) is a frequent complication of viral upper respiratory tract infection (URI). We hypothesized that the severity of nasopharyngeal cellular injury during URI, as measured by lactate dehydrogenase (LDH) concentrations in nasopharyngeal secretions (NPSs), is related to AOM complication.... |
Immunization by Replication-Competent Controlled Herpesvirus Vectors | Replication-competent controlled virus vectors were derived from the virulent herpes simplex virus 1 (HSV-1) wild-type strain 17syn+ by placing one or two replication-essential genes under the stringent control of a gene switch that is coactivated by heat and an antiprogestin. Upon activation of the gene switch, the ve... |
Communicable Diseases Prioritized According to Their Public Health Relevance, Sweden, 2013 | To establish strategic priorities for the Public Health Agency of Sweden we prioritized pathogens according to their public health relevance in Sweden in order to guide resource allocation. We then compared the outcome to ongoing surveillance. We used a modified prioritization method developed at the Robert Koch Instit... |
The Need for an Evidence-Based Encyclopaedia in Health Services Research in Pharmacy | Pharmacy practice research (PPR) is a specialty field within the wider area of health services research and it focuses on studies of how and why people access pharmacy services. This stream of research is also referred to as more universally recognized term such as health services research in pharmacy. The health servi... |
PubMed-cited research articles on the Middle East respiratory syndrome | |
A scoping review on bio-aerosols in healthcare and the dental environment | BACKGROUND: Bio-aerosols originate from different sources and their potentially pathogenic nature may form a hazard to healthcare workers and patients. So far no extensive review on existing evidence regarding bio-aerosols is available. OBJECTIVES: This study aimed to review evidence on bio-aerosols in healthcare and t... |
Blood and blood product use during COVID‐19 infection | |
Histology of skin lesions establishes that the vesicular rash associated with COVID‐19 is not “varicella‐like” | Several articles recently reported a “varicella‐like” rash in patients with COVID‐19 [1,2]. We observed similar cases at our institution. However, although we agree that the clinical picture is original, we reject that “varicella‐like” denomination since clinical presentation, as well as some histologic features that w... |
Characteristics and Outcomes of COVID-19 Positive Patients with Diabetes Managed as Outpatients | We analyzed disease outcomes for patients with diabetes and laboratory-confirmed COVID-19 who were managed outpatient and followed by the Emory COVID-19 Virtual Outpatient Management Clinic (ECVOMC). The rate of hospitalization for patients with diabetes was double the overall rate of hospitalization for patients in th... |
Hypertonic saline nasal irrigation and gargling for the common cold: Results of a pilot randomised controlled trial | |
Postobstructive Pneumonia: An Underdescribed Syndrome | Background. Postobstructive community-acquired pneumonia (PO-CAP) is relatively common in clinical practice. The clinical syndrome is poorly defined, and the role of infection as a cause of the infiltrate is uncertain. We prospectively studied patients with PO-CAP and compared them to a cohort of patients with bacteria... |
Molecular Targets for the Testing of COVID‐19 | The pandemic outbreaks of coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), spread all over the world in a short period of time. Efficient identification of the infection by SARS‐CoV‐2 has been one of the most important tasks to facilitate all the following cou... |
The Past, Present, and Future of Public Health Surveillance | This paper provides a review of the past, present, and future of public health surveillance—the ongoing systematic collection, analysis, interpretation, and dissemination of health data for the planning, implementation, and evaluation of public health action. Public health surveillance dates back to the first recorded ... |
Pathogenicity of a TW-Like Strain of Infectious Bronchitis Virus and Evaluation of the Protection Induced against It by a QX-Like Strain | Avian infectious bronchitis, a highly contagious disease caused by avian infectious bronchitis virus (IBV), is of considerable economic importance to the poultry industry. New IBV TW-like strains have increasingly emerged in China in recent years; hence, evaluating their pathogenicity and developing a specific vaccine ... |
Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection | The host cellular environment is a key determinant of pathogen infectivity. Viral gene expression and viral particle production of glucose-6-phosphate dehydrogenase (G6PD)–deficient and G6PD-knockdown cells were much higher than their counterparts when human coronavirus (HCoV) 229E was applied at 0.1 multiplicity of in... |
Vitamin D deficiency in patients with diabetes and COVID- 19 infection | BACKGROUND AND AIMS: Data show that vitamin D deficiency may play a role in patients with diabetes mellitus and COVID-19 infection. In this article, we review evidence of vitamin D deficiency and COVID-19 infection in context of diabetes mellitus. METHODS: A literature search was carried out by using the key term ‘COVI... |
China kickstarts its vaccine market | |
Pandemic influenza preparedness and health systems challenges in Asia: results from rapid analyses in 6 Asian countries | BACKGROUND: Since 2003, Asia-Pacific, particularly Southeast Asia, has received substantial attention because of the anticipation that it could be the epicentre of the next pandemic. There has been active investment but earlier review of pandemic preparedness plans in the region reveals that the translation of these st... |
Structure of dimeric full-length human ACE2 in complex with B0AT1 | Angiotensin-converting enzyme 2 (ACE2) is the surface receptor for SARS coronavirus (SARS-CoV), directly interacting with the spike glycoprotein (S protein). ACE2 is also suggested to be the receptor for the new coronavirus (2019-nCoV), which is causing a serious epidemic in China manifested with severe respiratory syn... |
A qualitative enquiry into strategic and operational responses to Covid‐19 challenges in South Asia | The Covid‐19 epidemic is a public health emergency of international concern. It poses a massive risk for the human race across the planet, calling for the need to take measures at the local, regional, national, and global levels. South Asian countries stand more vulnerable to the pandemic due to their dense population,... |
High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in piglets | BACKGROUND: Zinc (Zn) supplementation has been shown to reduce the incidence of diarrhea and to protect animals from intestinal diseases, but the mechanisms of this protective effect against virus infection in vivo have not yet been elucidated. Transmissible gastroenteritis virus (TGEV) causes diarrhea in piglets with ... |
Network opportunity | Our developing scientific understanding of complex networks is being usefully applied in a wide set of financial systems. What we've learned from the 2008 crisis could be the basis of better management of the economy — and a means to avert future disaster. |
The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches | Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been sugge... |
M-V Test validation and accreditation in the clinical virology laboratory | |
Detection of the Middle East Respiratory Syndrome Coronavirus Genome in an Air Sample Originating from a Camel Barn Owned by an Infected Patient | Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel betacoronavirus that has been circulating in the Arabian Peninsula since 2012 and causing severe respiratory infections in humans. While bats were suggested to be involved in human MERS-CoV infections, a direct link between bats and MERS-CoV is uncertai... |
Are genetic vaccines the right weapon against Covid-19? | |
Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado | Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections... |
Reduction of Natural Killer but Not Effector CD8 T Lymphoyctes in Three Consecutive Cases of Severe/Lethal H1N1/09 Influenza A Virus Infection | BACKGROUND: The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. METHODOLOGY/PRINCIPAL FINDINGS: We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregna... |
Evaluating performance of metagenomic characterization algorithms using in silico datasets generated with FASTQSim | Background In silico bacterial, viral, and human truth datasets were generated to evaluate available metagenomics algorithms. Sequenced datasets include background organisms, creating ambiguity in the true source organism for each read. Bacterial and viral datasets were created with even and staggered coverage to evalu... |
Is respiratory viral infection really an important trigger of asthma exacerbations in children? | We performed a prospective cohort study from September 2003 to December 2004 to delineate attributing the effect of different respiratory viral infections including newly discovered ones to asthma exacerbations in children in Hong Kong. One hundred and fourteen children aged 6–14 years with chronic stable asthma and on... |
Coccidioidomycosis as a Common Cause of Community-acquired Pneumonia | The early manifestations of coccidioidomycosis (valley fever) are similar to those of other causes of community-acquired pneumonia (CAP). Without specific etiologic testing, the true frequency of valley fever may be underestimated by public health statistics. Therefore, we conducted a prospective observational study of... |
Reporting, Recording and Communication of COVID-19 Cases in Workplace: Data Protection as a Moving Target | In response to concerns related to privacy in the context of COVID-19, recently European and national Data Protection Authorities (DPA) issued guidelines and recommendations addressing variety of issues related to processing of personal data for preventive purposes. One of the recurring questions in these guidelines re... |
Limited Transmission of Turkey Coronavirus in Young Turkeys by Adult Alphitobius diaperinus (Coleoptera: Tenebrionidae) | We examined the role of lesser mealworm, Alphitobius diaperinus (Panzer), in the transmission of an enteric disease of turkeys caused by a coronavirus. Turkey coronavirus (TCV) from two sources was studied, one isolate (NC95) was embryo propagated, the second was TCV infected material from turkeys diagnosed with poult ... |
Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms | Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortne... |
Prevention of Travel-Related Infectious Diseases in Families of Internationally Adopted Children | Pretravel consultation before international adoption must encompass standard advice for those who travel, advice for those who are exposed to the newly adopted child, and information about caring for a new child during travel. Children who travel to meet siblings may need special accommodations before and during travel... |
IFITM3 and Susceptibility to Respiratory Viral Infections in the Community | Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumo... |
Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus | We previously reported in randomized controlled trials that maoto, a traditional herbal medicine, showed clinical and virological efficacy for seasonal influenza. In this study, a culturing system for influenza was used to test the effect of maoto. A549 cells in the culture were infected with influenza virus A (PR8) an... |
Novel ionophores active against La Crosse virus identified through rapid antiviral screening | Bunyaviruses are significant human pathogens, causing diseases ranging from hemorrhagic fevers to encephalitis. Among these viruses, La Crosse virus (LACV), a member of the California serogroup, circulates in the eastern and midwestern United States. While LACV infection is often asymptomatic, dozens of cases of enceph... |
Indoor air quality audit implementation in a hotel building in Portugal | Abstract Hotels are designed to provide high levels of comfort for guests; however, frequent complaints related to uncomfortable thermal environment and inadequate indoor air quality (IAQ) appear. On the other hand, there is little research concerning IAQ audits of hotels up to now. This study is aimed to establish and... |
Socio-physical liveability through socio-spatiality in low-income resettlement archetypes - A case of slum rehabilitation housing in Mumbai, India | This study looks into the socio-physical liveability through socio-spatiality in low-income settlement archetypes. Paradoxically, recently mushrooming slum rehabilitation housing which have delivered secured tenure to its inhabitants, face threats of being deserted from lack of socio-physical liveability. Recurring of ... |
The nucleolus and viral infection | The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescen... |
An Australian Response to the COVID-19 Pandemic and its Implications on the Practice of Neurosurgery. | Abstract Objective This study was designed to assess the impact of public health policy in Australia in response to the Coronavirus disease 2019 (COVID-19) pandemic on the delivery of neurosurgical services. Being essential services, we postulated that there would not be a decrease in elective and emergency neurosurgic... |
Proteomic analysis of swine serum following highly virulent classical swine fever virus infection | BACKGROUND: Classical swine fever virus (CSFV) belongs to the genus Pestivirus within the family Flaviviridae. Virulent strains of classical swine fever virus (CSFV) cause severe disease in pigs characterized by immunosuppression, thrombocytopenia and disseminated intravascular coagulation, which causes significant eco... |
Surgery at the time of COVID‐19 pandemic: initial evidence of safe practice | |
Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses | BACKGROUND: The relationship between obesity and risk of complications described during the 2009 influenza pandemic is poorly defined for seasonal influenza and other viral causes of influenza‐like illness (ILI). METHODS: An observational cohort of hospitalized and outpatient participants with ILI was conducted in six ... |
The reality of dying in an intensive care unit with Covid-19 during the pandemic | |
Bending the arc of COVID-19 through a principled food systems approach | |
SARS-CoV-2 productively infects human gut enterocytes | The virus severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission via the respiratory route. However, clinical evidence suggests that the intestine may present another viral targ... |
Should RT‐PCR be considered a gold standard in the diagnosis of Covid‐19? | To face the new Covid‐19 pandemic, the need for early and accurate diagnosis of the disease among suspected cases quickly became obvious for effective management, and for better control of the spread of the disease in the population. Since the beginning of this disease epidemic caused by the severe acute respiratory sy... |
Chapter 11 Acute Exacerbations in Patients With Idiopathic Pulmonary Fibrosis | Abstract In spite of many studies, the real nature, etiology, pathobiology, and therapy of acute exacerbation (AEx) of idiopathic pulmonary fibrosis (IPF) are not clear. It seemed that AEx-IPF may be an acute acceleration of the underlying fibroproliferative process triggered by various extrinsic or unknown insults in ... |
First detection of SARS-CoV-2 by real-time reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay in pleural fluid | Abstract COVID-19 is a pandemic infection due to a novel coronavirus (SARS-CoV-2) spreading, resulting in a wide range of clinical features, from asyntomatic carriers to acute respiratory distress syndrome. The gold standard for diagnosis is nucleic acid detection by real-time reverse-transcriptase–polymerase-chain-rea... |
Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children | Abstract Background Two recently discovered polyomaviruses (PyV), WU and KI, have been identified in respiratory-tract specimens from children with acute respiratory infections, although there are limited data in HIV-infected children. Objectives To determine the prevalence and clinical manifestations of WUPyV and KIPy... |
Public perceptions of non-pharmaceutical interventions for reducing transmission of respiratory infection: systematic review and synthesis of qualitative studies | BACKGROUND: Non-pharmaceutical public health interventions may provide simple, low-cost, effective ways of minimising the transmission and impact of acute respiratory infections in pandemic and non-pandemic contexts. Understanding what influences the uptake of non-pharmaceutical interventions such as hand and respirato... |
Sexual Health in the SARS-CoV-2 Era | Sexual contact carries some risk for exposure to infection with severe acute respiratory syndrome coronavirus 2 during the coronavirus disease 2019 pandemic. This commentary provides clinicians with guidance on how to address sexual health and activity with patients in this context. |
Inflammatory Bowel Disease in the COVID-19 Pandemic – the Patients‘ Perspective | BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic is affecting lives worldwide. The influence of inflammatory bowel disease (IBD) medication and IBD itself on COVID-19 is controversial. Additionally, IBD focused guidance is scarce. OBJECTIVE: To determine COVID-19 prevalence/exposure, perception and informat... |
Stem Cell Research Responds to COVID-19: Deepak Srivastava, Fiona Watt, and George Daley | COVID-19 shutdowns have impacted research institutions across the globe. Cell Stem Cell asked Deepak Srivastava, Fiona Watt, and George Daley to share their perspectives on leadership during this crisis and how their institutions are supporting the scientific community to address this global health crisis. |
A twin challenge to handle: COVID‐19 with pregnancy | |
Structural Proteins in Severe Acute Respiratory Syndrome Coronavirus-2 | Abstract What began with a sign of pneumonia-related respiratory disorders in China has now become a pandemic named by WHO as Covid-19 known to be caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The SARS-CoV-2 are newly emerged β coronaviruses belonging to the Coronaviridae family. SARS-CoV-2 ha... |
Crystal structure of the C-terminal 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3 | In response to viral infections, the mammalian innate immune system induces the production of the second messenger 2’-5’ oligoadenylate (2–5A) to activate latent ribonuclease L (RNase L) that restricts viral replication and promotes apoptosis. A subset of rotaviruses and coronaviruses encode 2’,5’-phosphodiesterase enz... |
Las crisis de salud pública en una sociedad desarrollada. Aciertos y limitaciones en España. Informe SESPAS 2010 | Resumen La percepción, la aceptabilidad y la gestión de los riesgos son construcciones sociales, por lo que en el manejo de las crisis de salud pública la distancia entre hechos y creencias y sentimientos pone a prueba la capacidad de respuesta de las instituciones oficiales sanitarias ante alarmas que pueden ser objet... |
Increased fetuin A levels in Helicobacter pylori infection: a missing link between H. pylori and insulin resistance? | |
The impact of implementing respiratory point-of-care testing in a regional haemato-oncology unit | Respiratory point-of-care tests (POCT), detecting influenza A, influenza B and respiratory syncytial virus (RSV), were implemented in response to recent RSV outbreaks at a regional haemato-oncology unit in Glasgow. We provide a descriptive study of pre- and post- POCT implementation, which suggests POCT reduce the time... |
Low mortality rates related to respiratory virus infections after bone marrow transplantation | Respiratory viruses (RVs) frequently cause severe respiratory disease in bone marrrow transplant (BMT) recipients. To evaluate the frequency of RV, nasal washes were collected year-round from BMT recipients with symptoms of upper respiratory tract infection (URI). Direct immunofluorescence assay was performed for respi... |
Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses | Acute respiratory tract infections are caused by a large number of viruses. Diagnostic methods have until recently been available only for a limited number of these viruses. With the objective to achieve sensitive assays for all respiratory viruses, a rational workflow in the laboratory, and a short turn‐around time, a... |
Towards a genomics-informed, real-time, global pathogen surveillance system | The recent Ebola and Zika epidemics demonstrate the need for the continuous surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast, affordable sequencing of pathogen genomes — now a staple of the public health microbiology laboratory in well-resourced settings — can affect each of th... |
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