title stringlengths 0 221 | text stringlengths 0 375k |
|---|---|
Battling COVID-19 Pandemic: Sphingosine-1-Phosphate Analogs as an Adjunctive Therapy? | With the sudden outbreak of COVID-19 patient worldwide and associated mortality, it is critical to come up with an effective treatment against SARS-CoV-2. Studies suggest that mortality due to COVID 19 is mainly attributed to the hyper inflammatory response leading to cytokine storm and ARDS in infected patients. Sphin... |
SARS‐CoV‐2, skin lesions and the need of a multidisciplinary approach | COVID‐19 is a disease caused by severe acute respiratory syndrome coronavirus 2 of the genus Betacoronavirus (SARS‐CoV‐2). It was first described in Wuhan (China) on December 2019 and has spread to become a pandemic. Its clinical presentation is mainly characterized by cough, fever and dyspnea, although many other symp... |
Reinventing the wheel in ARDS: Awake proning in COVID-19 | |
Porcine respiratory coronavirus spread in Catalunya, Spain, a previously infection-free area | Abstract A retrospective study of sera from seven commercial pig herds was conducted from May 1985 to July 1989, showing that antibodies against Porcine Respiratory Coronavirus (PRCV) were first detected in Spain in September 1986. During 1991 a stratified sampling of breeding herds was conducted to establish prevalenc... |
Low testosterone levels predict clinical adverse outcomes in SARS‐CoV‐2 pneumonia patients | BACKGROUND: The pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS‐CoV‐2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical worsening and mortality. Epidemiological data showing a differential impact of SARS‐CoV‐2 infection on women and men ... |
Cytokine determinants of viral tropism | The specificity of a given virus for a ceil type, tissue or species — collectively known as viral tropism — is an important factor in determining the outcome of viral infection in any particular host. Owing to the increased prevalence of zoonotic infections and the threat of emerging and re-emerging pathogens, gaining ... |
The evolution of disease: anthropological perspectives on epidemiologic transitions | BACKGROUND: The model of epidemiologic transitions has served as a guiding framework for understanding relationships between patterns of human health and disease and economic development for the past several decades. However, epidemiologic transition theory is infrequently employed in epidemiology. OBJECTIVE: Moving be... |
A survey of the health and safety conditions of apartment buildings in Hong Kong | Abstract A high-density built environment poses challenges to the idea of sustainable development in respect of health (e.g. SARS outbreak) and safety (e.g. fire and structural problems). To examine the seriousness of the high-density problem, this study aims to survey the health and safety performance of apartment bui... |
Building International Genomics Collaboration for Global Health Security | Genome science and technologies are transforming life sciences globally in many ways and becoming a highly desirable area for international collaboration to strengthen global health. The Genome Science Program at the Los Alamos National Laboratory is leveraging a long history of expertise in genomics research to assist... |
Genetic characteristics and polymorphisms in the chicken interferon-induced transmembrane protein (IFITM3) gene | The interferon-induced transmembrane protein 3 (IFITM3) gene is classified as a small interferon-stimulated gene and is associated with a broad spectrum of antiviral functions against several fatal enveloped viruses, including influenza A viruses (IAVs). The rs12252 single nucleotide polymorphism (SNP) of the IFITM3 ge... |
Biologics increase the risk of SARS‐CoV‐2 infection and hospitalization, but not ICU admission and death: Real‐life data from a large cohort during red‐zone declaration | During COVID‐19 outbreak there are discordant opinions toward the impact on biologics in psoriatic (PsO) patients. Thus we performed a single‐center case‐control study in Lombardia, the Italian region with the higher number of COVID‐19 confirmed cases. We enrolled 1193 PsO patients treated with biologics and small mole... |
Telemedicine for preoperative assessment during a COVID-19 pandemic: Recommendations for clinical care | Limiting the spread of the disease is key to controlling the COVID-19 pandemic. This includes identifying people who have been exposed to COVID-19, minimizing patient contact, and enforcing strict hygiene measures. To prevent healthcare systems from becoming overburdened, elective and non-urgent medical procedures and ... |
Affordable Enteric Virus Detection Techniques Are Needed to Support Changing Paradigms in Water Quality Management | In light of water quality monitoring paradigms shifting to a more holistic approach, it is essential that environmental microbiologists embrace new methodological developments in clinical virology to create rapid, laboratory‐free methods for the identification of wastewater pollution. It is widely accepted that routine... |
I May Not Care About the Tenure Clock, but Enough Already! | |
Electronic cigarettes and vaping: toxicological awareness is increasing | |
Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro | The emergence of influenza viruses resistant to existing classes of antiviral drugs raises concern and there is a need for novel antiviral agents that could be used therapeutically or prophylacticaly. Surfactant protein D (SP-D) belongs to the family of C-type lectins which are important effector molecules of the innat... |
Role of bronchoscopy during non invasive ventilation in hypercapnic respiratory failure | Abstract Introduction Non invasive positive pressure ventilation (NIPPV) is the first line treatment for hypercapnic acute respiratory failure (ARF) secondary to COPD exacerbation in selected patients. Limited data exist supporting the use of fiberoptic bronchoscopy (FOB) during this clinical setting. The aim of this s... |
Chapter 42 Group IV Viruses Single-Stranded (+)Sense RNA | The Group IV viruses have a positive sense genome. Positive sense RNA can be translated directly into protein, without a DNA intermediate and without creating a complementary RNA strand. To replicate its genome, though, a complementary DNA strand is required. The positive RNA strand serves as a template for an RNA-depe... |
Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19 | ABSTRACT: An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various hu... |
Telecardiología en tiempos de la pandemia de COVID-19 | |
Impact de l’épidémie de Coronavirus-19 sur l’activité chirurgicale en ORL | Resume But: Le but de cette étude est d’évaluer l’impact de la pandémie Covid-19 sur l’activité chirurgicale de trois services d’ORL d’Ile-de-France, une région fortement touchée par l'épidémie. Matériel et Méthodes: Le nombre et la nature des interventions chirurgicales a été recueilli au sein de trois services d’ORL ... |
Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus (PEDV) field isolates in Korea | Porcine epidemic diarrhea virus (PEDV) has caused enteric disease with devastating impact since the first identification of PEDV in 1992 in Korea. In this study, we investigated molecular epidemiology, showed genetic diversity, and analyzed phylogenetic relationships of Korean PEDV field isolates with other PEDV refere... |
Histopathology and genetic susceptibility in COVID‐19 pneumonia | The clinical features of COVID‐19 range from a mild illness to patients with a very severe illness with acute hypoxemic respiratory failure requiring ventilation and Intensive Care Unit admission. Risk factors for a fatal disease include older age, respiratory disease, diabetes mellitus, obesity and hypertension. Littl... |
Deubiquitinating Activity of the SARS-CoV Papain-Like Protease | |
Akute Bronchitis | Abstract Acute bronchitis is one of the most frequent diagnoses made by family doctors and occurs in circa 5% of adults per year, cumulating during winter and autumn. Diagnosis is made purely clinically. Predominant symptoms are cough, fever, headache and pain in the limbs as well as general malaise. It can be conclude... |
Economic review | Abstract Severe acute respiratory syndrome (SARS) has taken its toll on Japanese companies operating in East Asia, according to a Japan External Trade Organization (JETRO) survey conducted in June. |
Hazard control by segregation in food factories | Factories are segregated primarily for protecting the product from the environment, segregation of raw materials and finished product, segregation of wet and dry materials, provision of mechanical and electrical services and health and safety issues (e.g. boiler rooms, chemical stores, fire hazards, noise limitation). ... |
Infectious Bronchitis Coronavirus Induces Cell-Cycle Perturbations | |
Chapter 20 The potential of exosomes as theragnostics in various clinical situations | Abstract Exosomes are membrane-bound cargo measuring 30–140nm comprised of a lipid bilayer containing various proteins, RNAs, DNAs, and bioactive lipids that can be transferred between cells. They have been shown to be produced and released by many different types of healthy and diseased cells. Exosomes are secreted by... |
Detection and Cellular Tropism of Porcine Astrovirus Type 3 on Breeding Farms | Astroviruses cause disease in a variety of species. Yet, little is known about the epidemiology of a majority of astroviruses including porcine astrovirus type 3 (PoAstV3), which is a putative cause of polioencephalomyelitis in swine. Accordingly, a cross-sectional study was conducted on sow farms with or without repor... |
Viral exanthem in COVID‐19, a clinical enigma with biological significance | Since December 2019, the COVID‐19 (1) has spread throughout the world at a staggering speed. As of March 30, 2020, the confirmed case number has reached 693,224 globally and the COVID‐19 has claimed 33,106 lives(2). Current researches emphasize on understanding of transmission patterns, severity, clinical features, and... |
The use of nucleic acid hybridization to detect human coronaviruses | We have applied an RNA: RNA hybridization test for the detection of human coronavirus 229E. This test is undergoing further development but already allows a diagnosis of HCV 229E infection within 48 hours. |
An assessment of World Health Organization criteria for severe acute respiratory syndrome in patients with cancer | BACKGROUND: The differential diagnosis of severe acute respiratory syndrome (SARS) in patients with cancer can be challenging. Although diagnostic criteria for SARS have been issued by the World Health Organization (WHO), simple adoption of the established criteria may lead to overdiagnosis in patients with cancer or t... |
To ease anxiety over coronavirus, leaders prescribe dose of common sense | Wash hands thoroughly. |
The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease | INTRODUCTION: Exacerbations are major contributors to morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and respiratory bacterial and viral infections are an important trigger. However, using conventional diagnostic techniques, a causative agent is not always found. Metagenomic next... |
Toward Precision Delivery of Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019 Cardiorespiratory Failure | |
Lessons learned from the COVID‐19 pandemic | The Coronavirus Disease 2019 (COVID-19) outbreak raises unique ethical dilemmas because it makes demands on society from all sectors of life, nationally and across the globe. Health professionals must deal with decisions about the allocation of scarce resources that can eventually cause moral distress and may affects o... |
Forecasting COVID-19 epidemic in India and high incidence states using SIR and logistic growth models | BACKGROUND: Ever since the Coronavirus disease (COVID-19) outbreak emerged in China, there has been several attempts to predict the epidemic across the world with varying degrees of accuracy and reliability. This paper aims to carry out a short-term projection of new cases; forecast the maximum number of active cases f... |
Does spatial proximity drive norovirus transmission during outbreaks in hospitals? | OBJECTIVE: To assess the role of spatial proximity, defined as patients sharing bays, in the spread of norovirus during outbreaks in hospitals. DESIGN: Enhanced surveillance of norovirus outbreaks between November 2009 and November 2011. METHODS: Data were gathered during 149 outbreaks of norovirus in hospital wards fr... |
Covid-19 in Critically Ill Patients in the Seattle Region — Case Series | BACKGROUND: Community transmission of coronavirus 2019 (Covid-19) was detected in the state of Washington in February 2020. METHODS: We identified patients from nine Seattle-area hospitals who were admitted to the intensive care unit (ICU) with confirmed infection with severe acute respiratory syndrome coronavirus-2 (S... |
Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis | Influenza is often complicated by bacterial pathogens that colonize the nasopharynx and invade the middle ear and/or lung epithelium. Incidence and pathogenicity of influenza-bacterial coinfections are multifactorial processes that involve various pathogenic virulence factors and host responses with distinct site- and ... |
Rapid Adaptation of a Surgical Research Unit to Conduct Clinical Trials during the Coronavirus-19 Pandemic. | The Coronavirus Disease 2019 (COVID-19) pandemic has brought most ongoing clinical trials to a standstill, while at the same time emphasizing the need for new therapeutic treatments and strategies to mitigate the morbidity and mortality related to COVID-19. Recent publication of several observational studies has genera... |
Sheep and goat vaccines | The relatively low economic value of small ruminants places constraints upon vaccination in these species. In general, vaccination against clostridial diseases such as enterotoxemia and tetanus are most important. Enzootic pneumonia is a major cause of losses in intensively housed sheep. Footrot is a difficult disease ... |
Asymptomatic COVID-19 Patients Can Contaminate Their Surroundings: an Environment Sampling Study | The contamination of patients’ surroundings by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains understudied. We sampled the surroundings and the air of six negative-pressure non-intensive care unit (non-ICU) rooms in a designated isolation ward in Chengdu, China, that were occupied by 13 laboratory... |
Minimizing contagion risks of COVID‐19 during Trans Oral Robotic Surgery | In this communication we would like to share our experience in managing TORS patients during COVID‐19 pandemia |
Feline herpesvirus infection. ABCD guidelines on prevention and management | Abstract Overview Feline viral rhinotracheitis, caused by feline herpesvirus (FHV), is an upper respiratory tract disease that is often associated with feline calicivirus and bacteria. In most cats, FHV remains latent after recovery, and they become lifelong virus carriers. Stress or corticosteroid treatment may lead t... |
Electroactive intercalators for DNA analysis on microchip electrophoresis | Miniaturized analytical systems, especially microchip CE (MCE), are becoming a promising tool for analytical purposes including DNA analysis. These microdevices require a sensitive and miniaturizable detection system such as electrochemical detection (ED). Several electroactive DNA intercalators, including the organic ... |
The Same Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) yet Different Outbreak Patterns and Public Health Impacts on the Far East Expert Opinion from the Rapid Response Team of the Republic of Korea | A Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) outbreak, the largest outbreak outside the Middle East in 2012, occurred in the Republic of Korea and resulted in a large number of cases, with 186 infected people, including 38 deaths. A Rapid Response Team (RRT) was appointed after a request from the Korean go... |
P-FAB: A Fiber-Optic Biosensor Device for Rapid Detection of COVID-19 | Rapid and low-cost diagnosis of COVID-19 is essential to identify the infected subjects, particularly the asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to RT-PCR, offer only limited help due to high false... |
Medical student elective during epidemics: a missed learning opportunity? | |
COVID-19 and Neurosurgical Education in Africa: Making lemonade from lemons | Abstract Never in history has the fabric of African Neurosurgery been challenged as it is today with the advent of covid-19. Even the most robust and resilient neurosurgical educational systems in the continent have been brought to their knees with Neurosurgical trainees and young neurosurgeons bearing the brunt. In th... |
Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions | The envelopes of coronaviruses (CoVs) contain primarily three proteins; the two major glycoproteins spike (S) and membrane (M), and envelope (E), a non-glycosylated protein. Unlike other enveloped viruses, CoVs bud and assemble at the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC). For efficient viri... |
Profile of natural anticoagulant, coagulant factor and anti-phospholipid antibody in critically ill COVID-19 patients | The outbreak of novel coronavirus disease 2019 (COVID-19) has now become a global pandemic. Coagulopathy has been reported widely in critically ill COVID-19 patients and was related to high mortality. However, the comprehensive coagulation profiles have not been examined and the underlying mechanism of the coagulopathy... |
Viral Impact in Autoimmune Diseases: Expanding the “X Chromosome–Nucleolus Nexus” Hypothesis | Viruses are suspected of significant roles in autoimmune diseases but the mechanisms are unclear. We get some insight by considering demands a virus places on host cells. Viruses not only require production of their own proteins, RNA and/or DNA, but also production of additional cellular machinery, such as ribosomes, t... |
An interesting case of acute disseminated encephalomyelitis following E. coli infection | Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of central nervous system (CNS), characterized by multifocal white matter involvement with neurological deficits and accompanied by encephalopathy. ADEM is thought to be caused by autoimmune etiology. CNS autoantigens are produced ... |
Respiratory surveillance wards as a strategy to reduce nosocomial transmission of COVID-19 through early detection: The experience of a tertiary-care hospital in Singapore | OBJECTIVES: Patients with COVID-19 may present with respiratory syndromes indistinguishable from those caused by common viruses. Early isolation and containment is challenging. Although screening all patients with respiratory symptoms for COVID-19 has been recommended, the practicality of such an effort has yet to be a... |
iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus | Abstract The re-emerging porcine epidemic diarrhea virus (PEDV) variant related diarrhea has been documented in China since late 2010 and now with global distribution. Currently, a virulent PEDV CH/YNKM-8/2013 and a CV777 vaccine strain-like AH-M have been successfully isolated from the clinical samples. To dissect out... |
Histopathology of COVID-19 pneumonia in two non-oncological, non-hospitalised cases as a reliable diagnostic benchmark | In lung cancer patients infected with COVID-19, pathological features are not easy to distinguish. This report presents detailed histopathological findings in two non-neoplastic subjects whose out-of-hospital deaths were caused by COVID-19 infection. These ‘pure’ cases differ in the time of presentation of symptoms, th... |
Host genes and influenza pathogenesis in humans: an emerging paradigm | The emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to s... |
Detection of viruses and atypical bacteria associated with acute respiratory infection of children in Hubei, China | BACKGROUND AND OBJECTIVE: Acute respiratory infection is the major cause of disease and death in children, particularly in developing countries. However, the spectrum of pathogenic viruses and atypical bacteria that exist in many of these countries remains incompletely characterized. The aim of this study was to examin... |
Sequence analysis of S1 genes of infectious bronchitis virus isolated in Thailand during 2008–2009: identification of natural recombination in the field isolates | During 2008–2009, fifteen field infectious bronchitis viruses (IBVs) were isolated from commercial chicken farms in Thailand. After sequencing of the complete S1 gene, phylogenetic analysis was performed and this found that the Thai IBV isolates were divided into three distinct groups, unique to Thailand (group I), QX-... |
Effectiveness of convalescent plasma therapy in severe COVID-19 patients | Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL of convalescent plasma (CP) derived from recently recovered donors with the neutralizing antib... |
Genetic, cellular and immune approaches to disease therapy: past and future | Advances in immunology and molecular genetics have accelerated our understanding of the genetic and cellular basis of many diseases. At the same time, remarkable progress in recombinant DNA technology has enabled the development of molecular and cellular treatments for infectious diseases, inherited disorders and cance... |
Immunoprophylaxis in fish by injection of mouse antibody genes | Antibodies are a crucial part of the body's specific defense against infectious diseases and have considerable potential as therapeutic and prophylactic agents in humans and animals. The development of recombinant single-chain antibodies allows a genetic application strategy for prevention of infectious diseases. To te... |
Insilico Alpha-Helical Structural Recognition of Temporin Antimicrobial Peptides and Its Interactions with Middle East Respiratory Syndrome-Coronavirus | Many antimicrobial peptides (AMPs) have multiple antimicrobial immunity effects. One such class of peptides is temporins. Temporins are the smallest (AMPs) found in nature and are highly active against gram-positive bacteria. Nowadays, there was a rapid increase in the availability of the 3D structure of proteins in PD... |
Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study | Rationale: The global death toll from coronavirus disease (COVID-19) virus as of May 12, 2020, exceeds 286,000. The risk factors for death were attributed to advanced age and comorbidities but have not been accurately defined. Objectives: To report the clinical features of 85 fatal cases of COVID-19 in two hospitals in... |
Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study | Introduction. HPV infection is a highly infectious disease; about 65% of partners of individuals with genital warts will develop genital condylomatosis. Only in 20-30% it regresses spontaneously and relapse rates range deeply (9-80%). Echinacea extracts possess antiviral and immunomodulator activities. The aim of this ... |
The experience of women infected by the COVID-19 during pregnancy in Brazil: a qualitative study protocol | BACKGROUND: The Coronavirus disease (COVID-19) is highly infectious, with the recent World Health Organization decree confirming a global public health emergency. The outcomes related to maternal and fetal health among pregnant women infected with the virus are still poorly understood. The world population has been wai... |
La surveillance des personnes contacts pour Ébola : effets sociaux et enjeux éthiques au Sénégal | Quarantine has been widely used during the Ebola outbreak in West Africa mainly to control transmission chains. This measure raises ethical issues that require documentation of the modalities of quarantine at the field level and its social effects for contact persons. In Senegal, 74 people were in contact with the Ebol... |
A Spatio‐Temporal Analysis of the Environmental Correlates of COVID‐19 Incidence in Spain | The novel SARS‐CoV2 has disrupted health systems and the economy, and public health interventions to slow its spread have been costly. How and when to ease restrictions to movement hinges in part on whether SARS‐CoV2 will display seasonality due to variations in temperature, humidity, and hours of sunshine. Here, we ad... |
Chapter 13 Diseases of the Gastrointestinal System | Abstract In captivity, gastrointestinal diseases are the most common clinical finding in common marmosets. Clinical signs may be due to a host of etiologies and typically manifest as weight loss, diarrhea, changes in eating habits, and/or abdominal distension. Proper recognition of clinical signs and identification of ... |
Surgical and endoscopy protocols for general surgeons during the COVID‐19 pandemic: an institutional experience in Singapore | |
Assessment of Chinese medicine for coronavirus-related pneumonia: A protocol for systematic review and meta-analysis | BACKGROUND: The 2019 novel coronavirus disease has caused a global pandemic with substantial morbidity and mortality. Chinese medicine has been extensively employed in the coronavirus-related pandemic in China. We aim to assess the efficacy and safety of Chinese medicine in treatment of coronavirus-related pneumonia wi... |
Cardiological Society of India Document on Safety Measure During Echo Evaluation of Cardiovascular Disease in the Time of COVID-19 | An echocardiographic investigation is one of the key modalities of diagnosis in cardiology. There has been a rising presence of cardiological comorbidities in patients positive for COVID-19. Hence, it is becoming extremely essential to look into the correct safety precautions, healthcare professionals must take while c... |
Staff perception and institutional reporting: two views of infection control compliance in British Columbia and Ontario three years after an outbreak of severe acute respiratory syndrome | Summary Few studies have audited the resources available to infection control (IC) and occupational health (OH) to promote safe work behaviour, whilst comparing audited findings with perceptions by healthcare workers (HCWs). We aimed to determine the IC and OH resources available and compare this with HCWs' perception ... |
The incidence of human bocavirus infection among children admitted to hospital in Singapore | Human bocavirus (HBoV) is a parvovirus, belonging to the genus Bocavirus. The virus was identified recently in Sweden, and has now been detected in several different countries. Although it is associated with lower respiratory tract infections in pediatric patients, the incidence of HBoV infection in a developed country... |
Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus | —Corona virus is a virus capable of mutating very quickly and many other viruses that arise due to mutations of this virus. To find out the location of corona virus mutations of one type to another, DNA sequences can be aligned using the Needleman-Wunsch algorithm. Corona virus data was taken from Genbank National Cent... |
Empagliflozin improves cardiac function in heart failure with reduced ejection fraction independent of loading conditions | The study regarding load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction is very interesting. But there are a few things we need to pay attention to. |
Productive infection of field strains of avian coronavirus infectious bronchitis virus in chicken peripheral blood-derived monocytes | The avian coronavirus infectious bronchitis virus (IBV) typically infects the respiratory tract of chickens, but can also spread to other organs. However, the mechanisms of virus dissemination are presently unclear. We show that peripheral blood-derived monocytes/macrophages from chickens (chPBMC) are productively infe... |
The Impact of Social Vulnerability on COVID-19 in the U.S.: An Analysis of Spatially Varying Relationships | Introduction Because of their inability to access adequate medical care, transportation, and nutrition, socially vulnerable populations are at increased risk of health challenges during disasters. This study estimates the association between case counts of coronavirus disease 2019 (COVID-19) infection and social vulner... |
Viroporins: Structures and Functions beyond Cell Membrane Permeabilization | |
Post-MI Ventricular Septal Defect during the COVID-19 Pandemic | Abstract: With the COVID-19 pandemic, the fear among the patients of contracting it have made them reluctant to seek medical attention on a timely basis even for emergent conditions. We present a case of post infarction ventricular septal rupture due to delayed presentation as a consequence of the fear of COVID-19. |
FFP2-mondmasker of chirurgisch mondkapje bij COVID-19 | Het aantal patiënten met COVID-19 neemt in rap tempo toe. Bescherming van medisch personeel is van groot belang om de ziekte onder medisch personeel te voorkomen en continuïteit in de zorg te waarborgen. Welk mondkapje heeft dan de voorkeur voor huisartsen: een FFP2-mondmasker of een chirurgisch mondkapje? Er is hierna... |
The risk of COVID19 Transmission in favelas and slums in Brazil | Abstract At a time when the COVID-19 pandemic affects a large part of the continents, populations who live in favelas and slums the impact of the spread of COVID-19 is not noticed, little is discussed between government and the population about these communities. There are few proposals for coping with COVID-19 in thes... |
Upper respiratory tract infections | Acute respiratory infections accounts for 20–40% of outpatient and 12–35% of inpatient attendance in a general hospital. Upper respiratory tract infections including nasopharyngitis, pharyngitis, tonsillitis and otitis media constitute 87.5% of the total episodes of respiratory infections. The vast majority of acute up... |
Microarray Detection of Human Parainfluenzavirus 4 Infection Associated with Respiratory Failure in an Immunocompetent Adult | A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray... |
Stable Internal Reference Genes for Normalizing Real-Time Quantitative PCR in Baphicacanthus cusia under Hormonal Stimuli and UV Irradiation, and in Different Plant Organs | Baphicacanthus cusia (Nees) Bremek, the plant source for many kinds of drugs in traditional Chinese medicine, is widely distributed in South China, especially in Fujian. Recent studies about B. cusia mainly focus on its chemical composition and pharmacological effects, but further analysis of the plant's gene functions... |
Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration | Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine is mediated by ceramidases. Altogether, five human ceramidases—named acid ceramidase, neutral... |
COVID‐19 and gastrointestinal endoscopy: what should be taken into account? | On March 11(th) 2020 the World Health Organisation (WHO) declared COVID‐19 pandemic, leading to a subsequent impact on the entire world and health care system. Since the causing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) houses in the aerodigestive tract, activities in the gastrointestinal outpatient ... |
Covid-19: Was Rheumapatienten jetzt wissen sollten: Handlungsempfehlungen der DGRh | Rheumapatienten gelten als Risikogruppe bei der Coronavirus-Krankheit COVID-19. Nicht nur die Erkrankung, auch die Therapien greifen in das Immunsystem ein. Die Deutsche Gesellschaft für Rheumatologie (DGRh) hat nun für betreuende Ärzte Empfehlungen auf Basis eines Expertenkonsens vorgelegt. |
Nasopharyngeal Microbiota in Children With Invasive Pneumococcal Disease: Identification of Bacteria With Potential Disease-Promoting and Protective Effects | Background and Aims: The risk of suffering from some infectious diseases can be related to specific microbiota profiles. Specifically, the nasopharyngeal microbiota could play a role as a risk or protective factor in the development of invasive disease caused by S. pneumoniae. Methodology: We analyzed the nasopharyngea... |
Dynamic cerebral autoregulation: A marker of post-operative delirium? | Abstract Objective We investigated the potential association of cerebral autoregulation (CA) with postoperative delirium (PD), a common complication of cardiac surgery with cardiopulmonary bypass (CPB). Methods In patients undergoing coronary artery bypass graft (CABG) surgery with CPB, cerebral blood flow velocity (CB... |
A metagenomics study for the identification of respiratory viruses in mixed clinical specimens: an application of the iterative mapping approach | Metagenomic approaches to detect viral genomes and variants in clinical samples have various challenges, including low viral titers and bacterial and human genome contamination. To address these limitations, we examined a next-generation sequencing (NGS) and iterative mapping approach for virus detection in clinical sa... |
Equity and fairness in a pandemic | |
Stroke and COVID19: not only a large-vessel disease | Recent evidence has underlined the association between large-vessel stroke and COVID-19, probably due to a proinflammatory and prothrombotic microenvironment induced by SARS-CoV-2. Here, we report the case of a young fit woman affected by COVID-19 without any flu-like symptom, who suffered from speech disorder and left... |
Development and validation of a TaqMan real-time reverse transcription-PCR for rapid detection of feline calicivirus | Feline calicivirus (FCV) is a common cause of upper respiratory tract disease in cats and is associated with interstitial pneumonia, oral ulceration and polyarthritis. Recently, outbreaks have involved a highly virulent FCV that leads to multisystemic signs. Virus isolation and conventional RT-PCR are the most common m... |
Singing Away the Social Distancing Blues: Art Therapy in a Time of Coronavirus | This essay explores the abundance of art flourishing as a therapeutic antidote to the COVID-19 pandemic and panic arising across the world. Specifically, I discuss how the act of viewing, making, and sharing music, street art, paintings, graphic art, cinema, and digital videos can serve as a therapeutic vehicle for emp... |
Hospitalized Patients With COVID-19 and Human Immunodeficiency Virus: A Case Series | |
COVID-19 in children and young people | |
COVID-19 in Children: Clinical Approach and Management | COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health crisis threatening humanity at this point in time. Transmission of the infection occurs by inhalation of infected droplets or direct contact with soiled surfaces and fomites. It should be suspected in all s... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.