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Radiological and nuclear terrorism: are you prepared? | Abstract Another terrorist attack on our nation is virtually inevitable. Most believe that it is not a question of if but when. The form of the terrorism, the time, and the place will not be of our choosing. Radiology professionals (radiologists, technologists, radiologists’ assistants, and nurses) will be involved in ... |
Identification of Hepta- and Octo-Uridine stretches as sole signals for programmed +1 and −1 ribosomal frameshifting during translation of SARS-CoV ORF 3a variants | Programmed frameshifting is one of the translational recoding mechanisms that read the genetic code in alternative ways. This process is generally programmed by signals at defined locations in a specific mRNA. In this study, we report the identification of hepta- and octo-uridine stretches as sole signals for programme... |
The management of coronavirus disease 2019 (COVID‐19) | In December 2019, a novel coronavirus causing severe acute respiratory disease occurred in Wuhan, China. It is an emerging infectious disease with widespread and rapid infectiousness. The World Health Organization declared the coronavirus outbreak to be a public health emergency of international concern on 31 January 2... |
A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5’-Monophospate Dehydrogenase activity | BACKGROUD: Influenza virus is still a huge threat to the world-wide public health. Host inosine-5’- monophosphate dehydrogenase (IMPDH) involved in the synthesis of guanine nucleotides, is known to be a potential target to inhibit the replication of viruses. Herein, we evaluated antiviral activity of a benzo-heterocycl... |
Economic impacts of Wuhan 2019‐nCoV on China and the world | Uncertainties over the Wuhan 2019 Novel Coronavirus (2019-nCoV), which has killed 1,017 people and sickened more than 43,100 as of Feb 11,1 has interrupted global trade and supply chains, depressed asset prices, and forced multinational businesses to make hard decisions with limited information. This article is protect... |
CT findings of patients infected with SARS-CoV-2 | BACKGROUND: We aimed to describe the chest CT findings in sixty-seven patients infected by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: We retrospectively reviewed 67 patients hospitalized in Ruian People’s Hospital. All the patients received the positive diagnosis of SARS-CoV-2 infection. The... |
Long Term Culture of Human Kidney Proximal Tubule Epithelial Cells Maintains Lineage Functions and Serves as an Ex vivo Model for Coronavirus Associated Kidney Injury | The mechanism of how SARS-CoV-2 causes severe multi-organ failure is largely unknown. Acute kidney injury (AKI) is one of the frequent organ damage in severe COVID-19 patients. Previous studies have shown that human renal tubule cells could be the potential host cells targeted by SARS-CoV-2. Traditional cancer cell lin... |
Identification of Capsid/Coat Related Protein Folds and Their Utility for Virus Classification | The viral supergroup includes the entire collection of known and unknown viruses that roam our planet and infect life forms. The supergroup is remarkably diverse both in its genetics and morphology and has historically remained difficult to study and classify. The accumulation of protein structure data in the past few ... |
Acute viral infections in immunocompetent patients | Abstract Viruses play a significant role in serious infections in adults and sometimes lead to the need for hospitalization and admission to intensive care units, especially in cases of severe respiratory distress or encephalopathy. Influenza and parainfluenza viruses, syncytial respiratory virus, herpes viruses and ad... |
Does my personal protective equipment really work? A simulation‐based approach | Healthcare workers have substantial concerns about the effectiveness of the personal protective equipment. Staff desired a refresher training with individual feedback of their abilities to don and doff effectively and assurance that if they donned and doffed correctly their equipment was effective. A nontoxic fluoresce... |
The role of microbes in the pathogenesis of acute rhinosinusitis in young adults | OBJECTIVES/HYPOTHESIS: To provide information on the course of acute rhinosinusitis (ARS) with sequential nasal and paranasal microbiological data and their correlation with clinical outcomes. STUDY DESIGN: We conducted a prospective cohort study among 50 Finnish military recruits with clinically diagnosed ARS in sprin... |
Perceived worsening of tics in adult patients with Tourette syndrome after the COVID‐19 outbreak | |
Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020 | PURPOSE OF REVIEW: The purposes of the review are as follows: (1) to define acute rhinosinusitis (ARS) and their phenotypes, (2) to highlight the ARS management according to international guidelines, (3) to compare the physicians’ management with the ARS guideline recommendations, and (4) to report ARS socioeconomic bu... |
Trust is a key factor in the willingness of health professionals to work during the COVID‐19 outbreak: Experience from the H1N1 pandemic in Japan 2009 | |
The association of viral proteins with host cell dynein components during virus infection | After fusion with the cellular plasma membrane or endosomal membranes, viral particles are generally too large to diffuse freely within the crowded cytoplasm environment. Thus, they will never reach the cell nucleus or the perinuclear areas where replication or reverse transcription usually takes place. It has been pro... |
Insights into pediatric multi-system inflammatory syndrome and COVID-19 | |
Molecular characterization of a panel of murine monoclonal antibodies specific for the SARS-coronavirus | Abstract The availability of monoclonal antibodies (mAbs) specific for the SARS-coronavirus (SARS-CoV) is important for the development of both diagnostic tools and treatment of infection. A molecular characterization of nine monoclonal antibodies raised in immune mice, using highly purified, inactivated SARS-CoV as th... |
Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study | BACKGROUND: Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological fea... |
Frontiers in Molecular Evolutionary Medicine | This paper surveys some of the important insights that molecular evolution has contributed to evolutionary medicine; they include phage therapy, cancer biology, helminth manipulation of the host immune system, quality control of gametes, and pathogen outbreaks. Molecular evolution has helped to revolutionize our unders... |
COVID-19: an update on diagnostic and therapeutic approaches | The unexpected pandemic set off by the novel coronavirus 2019 (COVID-19) has caused severe panic among people worldwide. COVID-19 has created havoc, and scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various steps have been taken ... |
Empirical Evidence for the Effect of Airline Travel on Inter-Regional Influenza Spread in the United States | BACKGROUND: The influence of air travel on influenza spread has been the subject of numerous investigations using simulation, but very little empirical evidence has been provided. Understanding the role of airline travel in large-scale influenza spread is especially important given the mounting threat of an influenza p... |
The potential of targeted antibody prophylaxis in SARS outbreak control: A mathematic analysis | Summary Background Severe acute respiratory syndrome (SARS) coronavirus-like viruses continue to circulate in animal reservoirs. If new mutants of SARS coronavirus do initiate another epidemic, administration of prophylactic antibodies to risk groups may supplement the stringent isolation procedures that contained the ... |
Cardiac injury and ARDS meta-analysis validity – Correspondence in response to Santoso et al. | |
Emerging and re-emerging infectious diseases: challenges and opportunities for militaries | The communal nature of living and training environments, alongside suboptimal hygiene and stressors in the field, place military personnel at higher risk of contracting emerging infectious diseases. Some of these diseases spread quickly within ranks resulting in large outbreaks, and personnel deployed are also often im... |
Immune checkpoint inhibitors in SARS-COV-2 infected cancer patients: the spark that ignites the fire? | |
The potential insights of Traditional Chinese Medicine on treatment of COVID-19 | Corona Virus Disease 2019 (COVID-19) broke out in 2019 and spread rapidly around the world. There is still no specific antiviral therapy to the current pandemic. In China, historical records show that Traditional Chinese Medicine (TCM) is effective in prevention and enhancing the resistance to pandemic with unique insi... |
Estimation of airborne viral emission: quanta emission rate of SARS-CoV-2 for infection risk assessment | Airborne transmission is a pathway of contagion that is still not sufficiently investigated despite the evidence in the scientific literature of the role it can play in the context of an epidemic. While the medical research area dedicates efforts to find cures and remedies to counteract the effects of a virus, the engi... |
Relapsing symmetric livedo reticularis in a patient with COVID‐19 infection | During the Coronavirus 2019 (COVID‐19) pandemic, several associated skin conditions were reported in infected patients, including; urticaria [1], exanthema [1], erythema multiforme [2], chickenpox‐like vesicles [1], pityriasis rosea [3], herpes simplex reactivation [4], erythema nodosum like Sweet’s syndrome [5], Symme... |
Parenteral Fish‐Oil Emulsions in Critically Ill COVID‐19 Emulsions | |
Seroepidemiologic Survey of Potential Pathogens in Obligate and Facultative Scavenging Avian Species in California | Throughout the world, populations of scavenger birds are declining rapidly with some populations already on the brink of extinction. Much of the current research into the factors contributing to these declines has focused on exposure to drug residues, lead, and other toxins. Despite increased monitoring of these declin... |
A large-scale location-based social network to understanding the impact of human geo-social interaction patterns on vaccination strategies in an urbanized area | Cities play an important role in fostering and amplifying the transmission of airborne diseases (e.g., influenza) because of dense human contacts. Before an outbreak of airborne diseases within a city, how to determine an appropriate containment area for effective vaccination strategies is unknown. This research treats... |
Improvement of SARS‐CoV2 symptoms following Guselkumab injection in a psoriatic patient | We read with great interest the publication of Messina et al (1) reporting the first case of SARS‐CoV2 infection in a young patient of 32‐year‐old suffering from psoriasis and psoriatic arthritis treated by Guselkumab, a monoclonal antibody that targets specifically the p19 subunit of Interleukin (IL)‐23(2).The patient... |
Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19 | BACKGROUND: Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. OBJECTIVES: To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. METHODS: Rem... |
Microarray-based identification of antigenic variants of foot-and-mouth disease virus: a bioinformatics quality assessment | BACKGROUND: The evolution of viral quasispecies can influence viral pathogenesis and the response to antiviral treatments. Mutant clouds in infected organisms represent the first stage in the genetic and antigenic diversification of RNA viruses, such as foot and mouth disease virus (FMDV), an important animal pathogen.... |
Medical Waste Management Practice during the 2019-2020 Novel Coronavirus Pandemic: Experience in a General Hospital | It is currently a critical period for the prevention and control of the COVID-19 pandemic. Since the medical waste disposal could be an important way to control the source of infection, standardization and strict implementation of the management of COVID-19 related medical waste should be with careful consideration to ... |
Rheumatologists rapidly adjust patient care during COVID-19 pandemic | |
Hybrid deep learning for detecting lung diseases from X-ray images | Lung disease is common throughout the world. These include chronic obstructive pulmonary disease, pneumonia, asthma, tuberculosis, fibrosis, etc. Timely diagnosis of lung disease is essential. Many image processing and machine learning models have been developed for this purpose. Different forms of existing deep learni... |
80 RETINAL AUTOANTIBODIES | ABSTRACT Retinal autoantibodies, commonly referred to as antiretinal antibodies (ARA), have been implicated in the pathogenicity of a variety of immune-mediated visual disorders. In the paraneoplastic syndrome, cancer-associated retinopathy (CAR), ARA with their targeted retinal antigens have been identified. There are... |
Management of patients with SARS-CoV-2 infections and of patients with chronic lung diseases during the COVID-19 pandemic (as of 9 May 2020): Statement of the Austrian Society of Pneumology (ASP) | The coronavirus disease 2019 (COVID-19) pandemic is currently a challenge worldwide. In Austria, a crisis within the healthcare system has so far been prevented. The treatment of patients with community-acquired pneumonia (CAP), including SARS-CoV‑2 infections, should continue to be based on evidence-based CAP guidelin... |
“It's about how much we can do, and not how little we can get away with”: Coronavirus-related legislative changes for social care in the United Kingdom | The coronavirus pandemic, referred to here as Covid-19, has brought into sharp focus the increasing divergence of devolved legislation and its implementation in the United Kingdom. One such instance is the emergency health and social care legislation and guidance introduced by the United Kingdom Central Government and ... |
Cutaneous manifestations in COVID‐19: the experiences of Barcelona and Rome | In December 2019, a new virus called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causing Coronavirus disease 2019 (COVID‐19) emerged in Wuhan, Hubei Province, China. SARS‐CoV‐2 is transmitted through respiratory droplets and object infected with droplets containing the virus. The diagnosis is made empl... |
Molecular characterization of an infectious bronchitis virus strain isolated from northern China in 2012 | This study reports the complete genome sequence of an infectious bronchitis virus (CK/CH/SD/121220, KJ128295) isolated in 2012 from Shandong Province in northern China. The genome is 27,666 nt long, comprising six genes and 5′ and 3′ untranslated regions. The full-length genome of the CK/CH/SD/121220 isolate had the hi... |
REHABILITACIÓN RESPIRATORIA EN PACIENTES CON COVID-19 | |
Prisoners in a pandemic: We should think about detainees during Covid-19 outbreak | In Italy, where the Covid-19 emergency developed immediately after China, the spread of the pandemic has highlighted some unsolved problems inherent to the prison system. This theme is already, unfortunately, of distressing topicality. Among these, the complex balance between the security needs and the protection of th... |
First detection of novel enterovirus G recombining a torovirus papain‐like protease gene associated with diarrhoea in swine in South Korea | Enterovirus species G (EV‐G) comprises a highly diversity of 20 genotypes that is prevalent in pig populations, with or without diarrhoea. In the present study, a novel EV‐G strain (KOR/KNU‐1811/2018) that resulted from cross‐order recombination was discovered in diagnostic faecal samples from neonatal pigs with diarrh... |
The Ebola epidemic is ongoing in West Africa and responses from China are positive | The ongoing Ebola outbreak poses an alarming risk to the countries of West Africa and beyond. On August 8, 2014, the World Health Organization (WHO) declared the cross-country Ebola outbreak a Public Emergency of International Concern. China has had no confirmed cases of Ebola. In this paper, virologic characteristics,... |
Comprehensive analysis of T cell epitope discovery strategies using 17DD yellow 2 fever virus structural proteins and BALB/c (H2(d)) mice model | Immunomics research uses in silico epitope prediction, as well as in vivo and in vitro approaches. We inoculated BALB/c (H2(d)) mice with 17DD yellow fever vaccine to investigate the correlations between approaches used for epitope discovery: ELISPOT assays, binding assays, and prediction software. Our results showed a... |
Influenza virus-induced oxidized DNA activates inflammasomes | Summary Influenza virus M2 and PB1-F2 proteins have been proposed to activate the Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in macrophages by altering intracellular ionic balance or mitochondrial reactive oxygen species (ROS) production. However, the precise mechanism by which these viral... |
Artificial intelligence for rapid identification of the coronavirus disease 2019 (COVID-19) | The coronavirus disease 2019 (COVID-19) outbreak that originated in Wuhan, China has rapidly propagated due to widespread person-to-person transmission and has resulted in over 1,133,758 cases in 197 countries with a total of 62,784 deaths as of April 5, 2020. Laboratory confirmation of SARS-CoV-2 is performed with a v... |
SAMHD1's protein expression profile in humans | The deoxynucleoside triphosphate triphosphohydrolase and 3′ → 5′ exonuclease SAMHD1 restricts HIV‐1 infection in noncycling hematopoietic cells in vitro, and SAMHD1 mutations are associated with AGS. Little is known about the in vivo expression and functional regulation of this cellular factor. Here, we first assessed ... |
Efficient Transduction of Dendritic Cells Using Coronavirus-Based Vectors | |
Prosthetic aortic valve endocarditis complicated by COVID‐19 and hemorrhage | The novel coronavirus, now termed SARS‐CoV‐2, has caused a significant global impact in the space of 4 months. Almost all elective cardiac surgical operations have been postponed with only urgent and emergency operations being considered in order to maximise resource utilisation. We present a case of a 69‐year old lady... |
The effect of Baihu Decoction (白虎汤) on blood glucose levels in treating systemic inflammatory response syndrome | In this paper we investigated the mechanisms of Baihu Decoction ((白虎汤, BH) and Baihu with Radix Ginseng (BHG) in treating systemic inflammatory response syndrome (SIRS) and sepsis in humans and animals. By reviewing published data on the effects of BH and BHG and the control of blood glucose in treating SIRS and sepsis... |
COVID-19: review and hematologic impact | Abstract In the last decades, coronaviruses have been a major threat to public health worldwide. SARS-CoV-2 is the third known coronavirus that causes fatal respiratory diseases in humans. The initial clinical features of SARS-CoV-2 infection are quite nonspecific and not all suspected patients can be tested to exclude... |
Functional Fcgamma Receptor Polymorphisms Are Associated with Human Allergy | OBJECTIVE: IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of FcγR genes (FCGR) are associated with human asthma and al... |
Cardio-onco-hematology patients’ management in the context of the current COVID-19 pandemic[[[es]]]Tratamiento de pacientes de cardio-onco-hematología durante la pandemia actual de COVID-19 | |
Reducing burden of disease from residential indoor air exposures in Europe (HEALTHVENT project) | BACKGROUND: The annual burden of disease caused indoor air pollution, including polluted outdoor air used to ventilate indoor spaces, is estimated to correspond to a loss of over 2 million healthy life years in the European Union (EU). Based on measurements of the European Environment Agency (EEA), approximately 90 % o... |
Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection | Porcine deltacoronavirus (PDCoV), a member of genus Deltacoronavirus, is an emerging swine enteropathogenic coronavirus (CoV). Although outstanding efforts have led to the identification of Alphacoronavirus and Betacoronavirus receptors, the receptor for Deltacoronavirus is unclear. Here, we compared the amino acid seq... |
Development and evaluation of a one-step multiplex real-time TaqMan(®) RT-qPCR assay for the detection and genotyping of equine G3 and G14 rotaviruses in fecal samples | BACKGROUND: Equine rotavirus A (ERVA) is the leading cause of diarrhea in neonatal foals and has a negative impact on equine breeding enterprises worldwide. Among ERVA strains infecting foals, the genotypes G3P[12] and G14P[12] are the most prevalent, while infections by strains with other genomic arrangements are infr... |
A microfluidic immunomagnetic bead-based system for the rapid detection of influenza infections: from purified virus particles to clinical specimens | Seasonal and novel influenza infections have the potential to cause worldwide pandemics. In order to properly treat infected patients and to limit its spread, a rapid, accurate and automatic influenza diagnostic tool needs to be developed. This study therefore presents a new integrated microfluidic system for the rapid... |
Comparison of loop-mediated isothermal amplification assay and smear microscopy with culture for the diagnostic accuracy of tuberculosis | BACKGROUND: Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of death from infectious diseases worldwide. Sputum smear microscopy remains the most widely available pulmonary TB diagnostic tool particularly in resource limited settings. A highly sensitive diagnostic with minimal infras... |
12.11 Alterations in Blood Components | Abstract Cellular blood components include leukocytes, erythrocytes, and platelets. Leukocyte subtypes are neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Red blood cell components include mature erythrocytes and reticulocytes. Increases or decreases in cell counts/concentrations for each of these bloo... |
Repurposing Disulfiram as an Anti-Obesity Drug: Treating and Preventing Obesity in High-Fat-Fed Rats | BACKGROUND AND OBJECTIVES: A drug repurposing strategy is an approach for identifying new therapeutic uses for approved or investigational drugs. Thanks to the moderate cost of repurposing a drug compared to bringing new chemical entity to the market, drug repurposing is rapidly gaining ground. The aim of this work is ... |
An optimal control theory approach to non-pharmaceutical interventions | BACKGROUND: Non-pharmaceutical interventions (NPI) are the first line of defense against pandemic influenza. These interventions dampen virus spread by reducing contact between infected and susceptible persons. Because they curtail essential societal activities, they must be applied judiciously. Optimal control theory ... |
Anxiety and depression levels among pregnant women with COVID‐19 | We read with great interest the Special Editorial by Dr Thapa and co-authors on the importance of not neglecting emotions of pregnant women during the COVID-19 pandemic1 as maternal mental health can be associated with short and long term risks for their and their children's physical and psychological health. Most stud... |
Governments and international institutions should urgently attend to the unjust disparities that COVID-19 is exposing and causing | |
Antiviral reactivities of γδ T cells | Abstract The complex antiviral immune mechanisms involve both adaptive and innate reactions mediated by γδ T lymphocytes, whose unique immunosurveillance contributions are analyzed here in different clinical and experimental settings. It is beyond any doubt that the fast, potent, cytotoxic as well as non-cytolytic anti... |
The perceived effectiveness of MERS-CoV educational programs and knowledge transfer among primary healthcare workers: a cross-sectional survey | BACKGROUND: Knowledge transfer of Middle East respiratory syndrome coronavirus (MERS-CoV) involves the dissemination of created/acquired information on MERS-CoV in hospitals, making this information accessible to all healthcare workers (HCWs). This study evaluated the perceived effectiveness of MERS-CoV educational pro... |
The paediatric weight management office visit via telemedicine: pre‐ to post‐COVID‐19 pandemic | Telemedicine is a powerful tool that erases many logistical barriers to care and may increase access. Due to the need for social distancing, the COVID‐19 pandemic has temporarily reduced in‐person visits for clinical care. Providers, clinical staff and patients are pressed to acutely learn new skills and adapt clinical... |
COVID-19 and ovarian cancer: Exploring alternatives to intravenous (IV) therapies | • The pandemic COVID-19 requires alternative methods and thinking to keep healthcare professionals and patients safe. • In COVID-19 hot spots, oral therapies may be viable alternatives to intravenous therapies for treatment of ovarian cancer. • Minimizing patient visits to hospitals and cancer clinics may help mitigate... |
The negative spillover effect of food crises on restaurant firms: Did Jack in the Box really recover from an E. coli scare? | Despite the enormous impact of food crises on restaurants, limited understanding of their long-term impacts and associated factors has undermined crisis managers’ ability to handle crisis situations effectively. This article investigated the long-term impact of food crises on the financial performance of restaurant fir... |
Recognizing flu-like symptoms from videos | BACKGROUND: Vision-based surveillance and monitoring is a potential alternative for early detection of respiratory disease outbreaks in urban areas complementing molecular diagnostics and hospital and doctor visit-based alert systems. Visible actions representing typical flu-like symptoms include sneeze and cough that ... |
“Mag ik weer op het spreekuur komen, dokter?” | “Dokter, mag ik weer op het spreekuur komen? Ik heb al een aantal dagen pijn in mijn buik, rechts, ook ’s nachts. Ik heb op Thuisarts.nl gekeken en daar staat dat ik u moet bellen.” |
The immune response to a recombinant Lactococcus lactis oral vaccine against foot-and-mouth disease virus in mice | OBJECTIVE: Development of an effective mucosal vaccine to induce specific immune responses against Foot-and-mouth disease virus (FMDV). RESULTS: For this purpose, the FMDV VP1 gene (SPVP1) was optimized and synthesized based on the codon bias of Lactococcus lactis (L. lactis), and then incorporated in the plasmid pNZ81... |
Structure-Based Stabilization of Non-native Protein–Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design | [Image: see text] Structure-based stabilization of protein–protein interactions (PPIs) is a promising strategy for drug discovery. However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. Here, we identified a non-native interaction interface... |
Public Health Lessons from Severe Acute Respiratory Syndrome a Decade Later | The outbreak of severe acute respiratory syndrome in 2002–2003 exacted considerable human and economic costs from countries involved. It also exposed major weaknesses in several of these countries in coping with an outbreak of a newly emerged infectious disease. In the 10 years since the outbreak, in addition to the in... |
Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective Efficacy | A new variant of the porcine epidemic diarrhea virus (PEDV) is an emerging swine disease, killing considerable numbers of neonatal piglets in North America and Asia in recent years. To generate immunogens mimicking the complex spike (S) protein folding with proper posttranslational modification to mount a robust immune... |
Infections with Influenza A/H3N2/ Subtype in Poland in the 2016/2017 Epidemic Season | The 2016/2017 epidemic season was characterized by a lower number of diagnostically tested samples of the nasal and throat swabs and bronchoalveolar lavage fluid, compared with the preceding season. The predominant influenza subtype found was A/H3N2/ which was notably diagnosed in patients over 25 years of age. This su... |
Mers coronavirus infection of rabbits | |
Setting Priorities Fairly in Response to Covid-19: Identifying Overlapping Consensus and Reasonable Disagreement | Proposals for allocating scarce lifesaving resources in the face of the covid-19 pandemic have aligned in some ways and conflicted in others. This paper attempts a kind of priority setting in addressing these conflicts. In the first part, we identify points on which we do not believe that reasonable people should diffe... |
Toward a Mechanistic Understanding of Environmentally Forced Zoonotic Disease Emergence: Sin Nombre Hantavirus | Understanding the environmental drivers of zoonotic reservoir and human interactions is crucial to understanding disease risk, but these drivers are poorly predicted. We propose a mechanistic understanding of human–reservoir interactions, using hantavirus pulmonary syndrome as a case study. Crucial processes underpinni... |
Co-infection with Bartonella henselae and Sarcocystis sp. in a 6-year-old male neutered domestic longhair cat with progressive multifocal neurological signs | |
A future for transgenic livestock | The techniques that are used to generate transgenic livestock are inefficient and expensive. This, coupled with the fact that most agriculturally relevant traits are complex and controlled by more than one gene, has restricted the use of transgenic technology. New methods for modifying the genome will underpin a resurg... |
Human bocavirus infections in hospitalized Greek children | INTRODUCTION: The epidemiology of human bocavirus (HBoV) infections has not been described in Greece, a south-eastern European country. To define the epidemiological profile and the clinical characteristics associated with HBoV infection in a population of children hospitalized with respiratory tract infection. MATERIA... |
Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers | Silver is easily available and is known to have microbicidal effect; moreover, it does not impose any adverse effects on the human body. The microbicidal effect is mainly due to silver ions, which have a wide antibacterial spectrum. Furthermore, the development of multidrug-resistant bacteria, as in the case of antibio... |
Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model | Abstract The infection of a novel coronavirus found in Wuhan of China (SARS-CoV-2) is rapidly spreading, and the incidence rate is increasing worldwide. Due to the lack of effective treatment options for SARS-CoV-2, various strategies are being tested in China, including drug repurposing. In this study, we used our pre... |
KAPITEL 13 Infektionskrankheiten | Zur Orientierung Infektionskrankheiten werden durch Pathogene verursacht, die sich im Wirt vermehren: Ektoparasiten, Helminthen, Protozoen, Pilze, Bakterien, Viren, Prionen. Infektionskrankheiten können alle Organe bzw. Organsysteme befallen. Entstehung und Verlauf werden durch Faktoren beeinflusst, die sich grob einte... |
Lipid nanoparticle technology for therapeutic gene regulation in the liver | Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief as they generally aim to alleviate disease symptoms. Targeting the root cause of diseases originating in the liver... |
Major advances in managing community-acquired pneumonia | This article is a non-systematic review of selected recent publications in community-acquired pneumonia, including a comparison of various guidelines. Risk stratification of patients has recently been advanced by the addition of several useful biomarkers. The issue of single versus dual antibiotic treatment remains con... |
Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human | At present, more than 200 countries and territories are directly affected by the coronavirus disease-19 (COVID-19) pandemic. Incidence and case fatality rate are significantly higher among elderly individuals (age > 60 years), type 2 diabetes and hypertension patients. Cellular receptor ACE2, serine protease TMPRSS2 an... |
Looking Back, Looking Forward | |
Emerging diseases in Bangladesh: Current microbiological research perspective | Abstract Bangladesh has experienced a variety of diseases caused by natural dissemination of an array of pathogenic microorganisms into the environment. While cures for these diseases largely depend on the medication strategies of physicians, determining the reasons for disease persistence as well for the onset of rein... |
Modeling and forecasting trend of COVID-19 epidemic in Iran until May 13, 2020 | Background: COVID-19 is a new disease and precise data are not available about this illness in Iran and in the world. Thus, this study aimed to determine the epidemic trend and prediction of COVID-19 in Iran. Methods: This was a secondary data analysis and modeling study. The daily reports of definitive COVID-19 patien... |
Severe community-acquired adenovirus pneumonia in an immunocompetent 44-year-old woman: a case report and review of the literature | INTRODUCTION: This case report describes a rare condition: community-acquired adenovirus pneumonia in an immunocompetent adult. The diagnosis was achieved by using a multiplex real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay and highlights the usefulness of these novel molecular diagnostic techn... |
An implementation of real-time air quality and influenza-like illness data storage and processing platform | Abstract Recently, air pollution has become the primary concern in Taiwan as it significantly affected people's health. Some air pollution monitoring, analysis, and prediction systems were proposed to solve the problem. However, there is very little research to see whether the air quality is associated with the Influen... |
Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis | Abstract Background Some disease-modifying agents commonly used to treat patients with rheumatic diseases/autoimmune disorders, such as hydroxychloroquine and colchicine, are under investigation as potential therapies for the “coronavirus disease 2019” (COVID-19). However, the role of such agents as prophylactic tools ... |
Vaccines for emerging pathogens: prospects for licensure | Globally, there are a number of emerging pathogens. For most, there are no licensed vaccines available for human use, although there is ongoing research and development. However, given the extensive and increasing list of emerging pathogens and the investment required to bring vaccines into clinical use, the task is hu... |
Biodegradable Nanoparticle-Entrapped Vaccine Induces Cross-Protective Immune Response against a Virulent Heterologous Respiratory Viral Infection in Pigs | Biodegradable nanoparticle-based vaccine development research is unexplored in large animals and humans. In this study, we illustrated the efficacy of nanoparticle-entrapped UV-killed virus vaccine against an economically important respiratory viral disease of pigs called porcine reproductive and respiratory syndrome v... |
“The ancient and the new”: is there an interaction between cytomegalovirus and SARS-CoV-2 infection? | The SARS-CoV-2 pandemic represents one of the greatest infectious challenges to humanity in recent history. One of the striking features of infection is the heterogeneous clinical response with worse outcomes observed in older patients and those with underlying health conditions. To date the potential impact of previou... |
40 Cruise Ship Travel | Abstract Cruise ships can be amplifiers of infectious diseases because of the close human proximity of semiclosed ship environments. The most common diagnoses of cruise passengers evaluated in cruise ship infirmaries include upper respiratory infections, injury, seasickness, and gastrointestinal illness. Cruise ship pa... |
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