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Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination | BACKGROUND: DNA vaccines have emerged as attractive candidates for the control of human papillomavirus (HPV)-associated malignancies. However, DNA vaccines suffer from limited immunogenicity and thus strategies to enhance DNA vaccine potency are needed. We have previously demonstrated that for DNA vaccines encoding HPV... |
Aerosol Risk with Noninvasive Respiratory Support in Patients with COVID‐19 | OBJECTIVES: This study evaluates aerosol production with high flow nasal cannula (HFNC) and noninvasive positive pressure ventilation (NIPPV) compared to six liters per minute by low‐flow nasal cannula. METHODS: Two healthy volunteers were randomized to control (six liters per minute by low‐flow nasal cannula), NIPPV, ... |
DA rats from two colonies differ genetically and in their arthritis susceptibility | The arthritis-susceptible DA rat is one of the most commonly used rat strains for genetic linkage analysis and is instrumental for the identification of many genetic loci. Even though DA rats were kept as inbred lines at different institutes and suppliers, it became obvious that the various breeding stocks differed gen... |
SARS-CoV-2–Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19 | |
TREADING LIGHTLY IN A PANDEMIC: #ZENTENSIVIST REFLECTIONS ON COVID-19 | |
Urgencias quirúrgicas no relacionadas con la pandemia COVID-19. Caso clínico: Hernia interna yeyunal complicada con necrosis intestinal en el ligamento ancho utero-ovárico (LAUO) | |
Prevalence and phylogenetic analysis of canine kobuviruses in diarrhoetic dogs in northeast China | Canine kobuviruses (CaKVs) are newly recognized picornaviruses that have been recently detected in dogs in the U.S.A., Italy, U.K., the Republic of Korea and Tanzania. To trace the evolution of CaKV strains, a total of 201 fecal samples from rectal swabs of diarrheic dogs, which were obtained from May 2014 to April 201... |
7 Pretravel Considerations for Non-vaccine-Preventable Travel Infections | Abstract Pretravel advice should be tailored to the individual following a thorough review of his or her itinerary, planned activities, and host characteristics. In addition to vaccinations and malaria chemoprophylaxis, a pretravel consultation should include advice on regionally endemic or emerging non–vaccine-prevent... |
Response to The challenges of diagnosing heparin‐induced thrombocytopenia in patients with COVID‐19 | We thank May et al for their comments, expanding the number of reported cases of suspected and confirmed heparin‐induced thrombocytopenia (HIT) associated with COVID‐19, and reemphasizing the complexity of the prothrombotic state observed (1). We agree that false‐positive enzyme immunoassay (EIA) detection of anti‐plat... |
Symmetric peripheral polyarthritis developed during SARS-CoV-2 infection | |
Commentary: COVID-19 and Obesity: Exploring Biologic Vulnerabilities, Structural Disparities, and Weight Stigma | |
Hypovitaminosis D and COVID-19: Matter of Concern in India? | |
Viral Metagenomics on Cerebrospinal Fluid | Identifying the causative pathogen in central nervous system (CNS) infections is crucial for patient management and prognosis. Many viruses can cause CNS infections, yet screening for each individually is costly and time-consuming. Most metagenomic assays can theoretically detect all pathogens, but often fail to detect... |
Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population | OBJECTIVE: To examine the association of a range of psychosocial factors with hospitalisation for COVID-19. DESIGN: Prospective cohort study. SETTING: England. PARTICIPANTS: UK Biobank comprises around half a million people who were aged 40 to 69 years at study induction between 2006 and 2010 when information on psycho... |
RAS-Inhibition in Zeiten der COVID-19-Pandemie — aktuelle ESH-Empfehlungen: Seminar / Hypertonie | Die COVID-19 Task Force der European Society of Hypertension (ESH) hat sich in einem Review erneut zur Bedeutung von Bluthochdruck und therapeutischer RAS-Blockade bei COVID-19-Patienten geäußert. Dargestellt und kritisch diskutiert werden v. a. die molekularen Mechanismen der Infektion und der RAS-Hemmung sowie die po... |
Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026) | |
Innate and adaptive immunity: specificities and signaling hierarchies revisited | The conventional classification of known immune responses by specificity may need re-evaluation. The immune system can be classified into two subsystems: the innate and adaptive immune systems. In general, innate immunity is considered a nonspecific response, whereas the adaptive immune system is thought of as being ve... |
Planning for COVID-19 Vaccines Safety surveillance | |
Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea | MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 ca... |
Clinical outcomes of 402 patients with COVID‐2019 from a single center in Wuhan, China | The outbreak of SARS‐CoV‐2 has become a pandemic with significant mortality. Published studies describing clinical characteristics of the disease contain small cohorts from individual centers or larger series consisting of mixed series from multiple different hospitals. We report here analyses of mortality and disease ... |
Exercise as medicine for COVID-19: an ACE in the hole? | |
Optical theranostics and treatment dosimetry for COVID-19 lung complications: towards increasing the survival rate of vulnerable populations | • Although social isolation measures and adaptation of the healthcare system slowed the progress of the COVID-19 pandemic, no effective treatments are available for severe lung complications. • Optical theranostics methods can identify COVID-19 pulmonary manifestations and provide automated and real-time control of the... |
Combination Therapy Using Chimeric Monoclonal Antibodies Protects Mice from Lethal H5N1 Infection and Prevents Formation of Escape Mutants | BACKGROUND: Given that there is a possibility of a human H5N1 pandemic and the fact that the recent H5N1 viruses are resistant to the anti-viral drugs, newer strategies for effective therapy are warranted. Previous studies show that single mAbs in immune prophylaxis can be protective against H5N1 infection. But a singl... |
Identification of viral agents associated with diarrhea in young children during a winter season in Beijing, China | Abstract Background Viral diarrhea remains a major cause of childhood morbidity and mortality worldwide. Although rotavirus was extensively studied in China, few comprehensive studies of all viral agents related to diarrhea in children have been conducted. Objectives Our study was performed to investigate the role of e... |
The Association Between Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and the Number of Covid-19 Confirmed Cases and Deaths in the United States: Geospatial Study | Background: The novel coronavirus SARS-Cov2 uses the angiotensin-converting enzyme 2 (ACE2) receptor as an entry point to the cell. Cardiovascular disease (CVD) is a risk factor for the novel coronavirus disease (Covid-19) with poor outcomes. We hypothesized that the rate of ACE inhibitors (ACEIs) and angiotensin recep... |
Can biowarfare agents be defeated with light? | Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination of viruses, bacteria, spores, fungi, or toxins. Dissemination may be airborne, waterborne, or b... |
Prediction of Pediatric Critical Care Resource Utilization for Disaster Triage | Pediatric protocols to guide allocation of limited resources during a disaster lack data to validate their use. The 2011 Pediatric Emergency Mass Critical Care Task Force recommended that expected duration of critical care be incorporated into resource allocation algorithms. We aimed to determine whether currently avai... |
Spatial organization and activity patterns of the masked palm civet (Paguma larvata) in central-south China | Movement and activity patterns are important components of life history, being central to resource acquisition and defense, mating behavior, and individual survival and fitness. Here, we present results from the 1st systematic radiotracking study of the masked palm civet (Paguma larvata), a widespread viverrid found in... |
Evaluation of Antiviral Therapies for Coronavirus Disease 2019 (COVID‐19) Pneumonia in Shanghai, China | The aim of our study was to evaluate the therapeutic effect of antiviral drugs on COVID‐19 pneumonia. Patients confirmed with COVID‐19 pneumonia were enrolled and divided into 7 groups according to the treatment option. Information including age, gender and duration from illness onset to admission, clinical manifestati... |
Will heat kill the coronavirus? | We don't know if changing seasons will help stem the outbreak, says Michael Le Page |
Chapter 7 Pathogenesis | Publisher Summary Virus pathogenesis is a complex, variable, and relatively rare state. Like the course of a virus infection, pathogenesis is determined by the balance between host and virus factors. Not all the pathogenic symptoms seen in virus infections are caused directly by the virus but are side effects of the im... |
The uses of disorder in negotiated information orders: information leveraging and changing norms in global public health governance | The SARS epidemic that broke out in late 2002 in China’s Guangdong Province highlighted the difficulties of reliance on state‐provided information when states have incentives to conceal discrediting information about public health threats. Using SARS and the International Health Regulations (IHR) as a starting point, t... |
The POP-DOC Loop: A continuous process for situational awareness and situational action | Abstract Among the most critical challenges crisis leaders face is evaluating “the situation”—what is happening and what to do about it. Extensive scholarship on Situational Awareness (SA) has identified a gap: a disciplined process for achieving accurate SA. Further, SA only addresses the first half of that situation ... |
Don’t Uncover that Face! Covid-19 Masks and the Niqab: Ironic Transfigurations of the ECtHR’s Intercultural Blindness | This essay, between serious and facetious, addresses an apparently secondary implication of the planetary tragedy produced by Covid-19. It coincides with the ‘problem of the veil,’ a bone of contention in Islam/West relationships. More specifically, it will address the question of why the pandemic has changed the proxe... |
Evaluation of Antiseptic Antiviral Activity of Chemical Agents | Antiviral antisepsis and disinfection are crucial for preventing the environmental spread of viral infections. Emerging viruses and associated diseases, as well as nosocomial viral infections, have become a real issue in medical fields, and there are very few efficient and specific treatments available to fight most of... |
Elevated troponin in patients with Coronavirus Disease 2019 (COVID-19): possible mechanisms | Abstract Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 1.8 million people worldwide, overwhelmed health care systems due to the high proportion of critical presentations, and resulted in over 100,000 deaths. Since the first data analyses in China, elevated cardiac troponin has been noted... |
Nucleocapsid-independent assembly of coronavirus-like particles by co-expression of viral envelope protein genes. | Budding of enveloped viruses has been shown to be driven by interactions between a nucleocapsid and a proteolipid membrane. By contrast, we here describe the assembly of viral envelopes independent of a nucleocapsid. Membrane particles containing coronaviral envelope proteins were assembled in and released from animal ... |
H7N9 avian influenza virus - search and re-search | |
SARS‐CoV‐2 infection in a psoriatic patient treated with IL‐17 inhibitor | we read with great interest the article entitled “SARS‐CoV‐2 infection in a psoriatic patient treated with IL‐23 inhibitor” published by Messina F. and Piaserico S. in the JEADV.(1) This is the first report of COronaVIrus DIsease 2019 (COVID‐19) in a psoriatic patient treated with a biologic. Whilst the authors reporte... |
Dose-dependent effects of specific egg-yolk antibodies on diarrhea of newborn calves | Abstract In a field trial on a farm in Turkey, we tested whether specific egg-yolk antibodies had a prophylactic effect on neonatal diarrhea. Owing to its antibody spectrum, this egg powder was very suitable for this farm since mainly rotavirus was identified. Regardless of the dosage (2 g, 4 g, or 8 g egg powder), the... |
Impact of human mobility on the transmission dynamics of infectious diseases | Spatial heterogeneity is an important aspect to be studied in infectious disease models. It takes two forms: one is local, namely diffusion in space, and other is related to travel. With the advancement of transportation system, it is possible for diseases to move from one place to an entirely separate place very quick... |
Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM | Infection of mice with variants of mouse hepatitis virus, strain JHM (MHV-JHM), provide models of acute and chronic viral infection of the central nervous system (CNS). Through targeted recombination and reverse genetic manipulation, studies of infection with MHV-JHM variants have identified phenotypic differences and ... |
Potential Broad Spectrum Inhibitors of the Coronavirus 3CL(pro): A Virtual Screening and Structure-Based Drug Design Study | Human coronaviruses represent a significant disease burden; however, there is currently no antiviral strategy to combat infection. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) less than 10 years later demonstrates the potential of coronaviruses to cross sp... |
Comment on: “Controversies regarding mask usage in ophthalmic units in the United Kingdom during the COVID-19 pandemic” | |
Applications of Plant Viruses in Bionanotechnology | The capsids of most plant viruses are simple and robust structures consisting of multiple copies of one or a few types of protein subunit arranged with either icosahedral or helical symmetry. In many cases, capsids can be produced in large quantities either by the infection of plants or by the expression of the subunit... |
Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport | The importin-α family of proteins plays an important role in the eukaryotic importin/exportin nuclear transport system. These proteins recognize a nuclear localization signal (NLS) within cargo proteins and import them into the nucleus through nuclear pores, in a process mediated by importin-β. Recent studies have show... |
Diverse gammacoronaviruses detected in wild birds from Madagascar | To date, infectious bronchitis virus (IBV) is potentially found in wild birds of different species. This work reports the survey of coronaviruses in wild birds from Madagascar based on the targeting of a conserved genome sequence among different groups of CoVs. Phylogenetic analyses revealed the presence of gammacorona... |
Medical and Surgical Emergencies in Ferrets | In the last few years, significant improvement in diagnosis and treatment of ferret emergencies has occurred. Scientific advances demonstrated the need of specific practices when dealing with emergencies in ferrets. The risk of overdiagnosis of hypoglycemia with human portable blood glucose meters is a clear example. T... |
CPAP Added to Oxygen Administration Avoid Intubation in Acute Respiratory Distress in COVID-19 Pneumonia. Case Report | It was recently described that COVID-19 pneumonia patients had an atypical form of the ARDS syndrome and required gentle ventilation. We report here on benefits of CPAP treatment in a patient with COVID-19 pneumonia. A 63-year-old patient of African origin presented to the emergency room with COVID-19 pneumonia. Fever ... |
COVID-19 projections for reopening Connecticut | Closure of schools and the statewide "Stay Safe, Stay Home" order have effectively reduced COVID-19 transmission in Connecticut, with model projections estimating incidence at about 1,300 new infections per day. If close interpersonal contact increases quickly in Connecticut following reopening on May 20, the state is ... |
Insights into potential pathogenesis mechanisms associated with Campylobacter jejuni-induced abortion in ewes | BACKGROUND: Campylobacter jejuni is commonly found in the gastrointestinal tract of many food-animals including sheep without causing visible clinical symptoms of disease. However, C. jejuni has been implicated in ovine abortion cases worldwide. Specifically, in the USA, the C. jejuni sheep abortion (SA) clone has been... |
Endogenous R&D spillover and location choice in a mixed oligopoly | We consider a three-stage game where a public firm and a private firm choose R&D, location, and price, under the assumption that R&D spillovers rely on their locations. We show that, in equilibrium, whether the public firm engages in innovation more aggressively than the private firm depends on the degree of spillovers... |
COVID-19 and Japanese shareholder activism: brief respite for Japan’s self-healing concrete | Extrapolating from modern international understanding of corporate Japan’s distinct form of managerial capitalism, we elaborate on the growing momentum of shareholder activism in Japan leading up to the COVID-19 health crisis, so as to inform the subsequent discussion on the relevant primary considerations that belie t... |
A child with a severe multi‐system inflammatory syndrome following an asymptomatic COVID‐19 infection: a novel management for a new disease? | Clinical presentation of COVID‐19 disease is only in part due to viral infection itself, with the host response playing an important role.(1‐3) Despite the mild clinical course during the acute phase of infection in children, latest ongoing researches are pointing the attention towards a hyperinflammatory shock or a Ka... |
Determining Causality and Controlling Disease is Based on Collaborative Research involving Multidisciplinary Approaches | Understanding the causes of infectious disease to facilitate better control requires observational and experimental studies. Often these must be conducted at many scales such as at the molecular, cellular, organism, and population level. Studies need to consider both intrinsic and extrinsic factors affecting the pathog... |
A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection | BACKGROUND: Respiratory virus infection (RVI) in pediatric solid organ transplant (SOT) recipients poses a significant risk; however, the epidemiology and effects of an RVI after pediatric SOT in the era of current molecular diagnostic assays are unclear. METHODS: A retrospective observational cohort of pediatric SOT r... |
Therapeutic management of Crimean-Congo haemorrhagic fever | Abstract Crimean-Congo haemorrhagic fever has been reported in more than 30 countries in Africa, Asia, the Middle East and Eastern Europe, with an increasing incidence in recent years, especially in Europe. Because no specific treatments have demonstrated efficacy, supportive treatment is essential, as well as the prov... |
The potential impact of the next influenza pandemic on a national primary care medical workforce | BACKGROUND: Another influenza pandemic is all but inevitable. We estimated its potential impact on the primary care medical workforce in New Zealand, so that planning could mitigate the disruption from the pandemic and similar challenges. METHODS: The model in the "FluAid" software (Centers for Disease Control and Prev... |
Our education, our concerns: The impact on medical student education of COVID‐19 | March 2020, it seemed as if my world was turned upside down. I opened an email from my medical school dean of student affairs stating: Match Day, cancelled. The day that would determine where we trained as postgraduate residents, the day my class had worked towards for 4 years, cancelled due to this new virus that we s... |
Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study | BACKGROUND: Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 3 million patients globally. Previous data from Wuhan city showed that acute kidney injury (AKI), proteinuria and hematuria occurred frequently in patients with severe COVID-19. However, the prevalence of kidney injury in milder c... |
Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission | Abstract Membrane fusion and fission underlie two limiting steps of enveloped virus replication cycle: access to the interior of the host-cell (entry) and dissemination of viral progeny after replication (budding), respectively. These dynamic processes proceed mediated by specialized proteins that disrupt and bend the ... |
Glycyrrhizin prevents of lipopolysaccharide/D‐galactosamine‐induced liver injury through down‐regulation of matrix metalloproteinase‐9 in mice | Glycyrrhizin, a biological active compound isolated from the liquorice root, has been used as a treatment for chronic hepatitis. We have examined the involvement of matrix metalloproteinase (MMP)‐9 in the development of lipopolysaccharide (LPS) and D‐galactosamine (GalN)‐induced liver injury in mice. We also investigat... |
Neurological immunotherapy in the era of COVID-19 — looking for consensus in the literature | The coronavirus disease 2019 (COVID-19) pandemic is concerning for patients with neuroimmunological diseases who are receiving immunotherapy. Uncertainty remains about whether immunotherapies increase the risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or increase the risk of severe ... |
SARS CTL vaccine candidates; HLA supertype‐, genome‐wide scanning and biochemical validation | Abstract: An effective Severe Acute Respiratory Syndrome (SARS) vaccine is likely to include components that can induce specific cytotoxic T‐lymphocyte (CTL) responses. The specificities of such responses are governed by human leukocyte antigen (HLA)‐restricted presentation of SARS‐derived peptide epitopes. Exact knowl... |
A review of treatment modalities for Middle East Respiratory Syndrome | The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been a focus of international attention since its identification in 2012. Epidemiologically it is characterized by sporadic community cases, which are amplified by hospital-based outbreaks. Healthcare facilities in 27 countries from most continents have ex... |
To punish or to assist? Divergent reactions to ingroup and outgroup members disobeying social distancing | In response to the COVID‐19 pandemic, societies face the formidable challenge of developing sustainable forms of sociability‐cumsocial‐distancing – enduring social life while containing the virus and preventing new outbreaks. Accordant public policies often balance between retributive (punishment‐based) and assistance ... |
Comment les enfants et adolescents avec le trouble déficit d’attention/hyperactivité (TDAH) vivent-ils le confinement durant la pandémie COVID-19 ? | OBJECTIVES: During the COVID-19 pandemic, the French government has decided a general lockdown. This unprecedented situation has raised concerns about children's and adolescent's mental health. Children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD) may find this context of restrained ac... |
Viral quantity and pathological changes in broilers experimentally infected by IRFIBV32 isolate of infectious bronchitis virus | An Iranian isolate of avian infectious bronchitis virus IRFIBV32 was quantified in experimentally infected broilers using real-time reverse transcriptase polymerase chain reaction and histopathological changes was investigated. Thirty-six 3-week-old commercial broilers were inoculated by 10(5) ELD50/0.1 ml of the virus... |
Protection of CT suites from COVID‑19 infection in a tertiary emergency hospital | |
Responding to COVID-19: What’s the Problem? | This commentary argues that the coronavirus SARS-CoV-2 pandemic should be considered as a transdisciplinary societal challenge that requires coordinated systemic thinking and actions in the context of uncertainty. Responses to the propagation of the coronavirus SARS-CoV-2 and the health, economic and social impacts of ... |
Global surgery in the time of COVID-19: A trainee perspective | |
Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China | BACKGROUND: No comprehensive analysis is available on the viral etiology and clinical characterization among children with severe acute respiratory infection (SARI) in China during 2009 H1N1 pandemic and post-pandemic period. METHODS: Cohort of 370 hospitalized children (1 to 72 months) with SARI from May 2008 to March... |
The identification and characterization of nucleic acid chaperone activity of human enterovirus 71 nonstructural protein 3AB | Abstract Human enterovirus 71 (EV71) belongs to the genus Enterovirus in the family Picornaviridae and has been recognized as one of the most important pathogens that cause emerging infectious disease. Despite of the importance of EV71, the nonstructural protein 3AB from this virus is little understood for its function... |
11 Contingency Planning Emergency Response and Safety | Abstract Although there is some recognition of the importance of contingency planning, far too few firms have anything beyond a contingency plan that sits on a shelf in the CEO’s office. Even in those companies with crisis management teams (CMTs), the members often do not meet to plan or even discuss how the team would... |
“Diseases and Natural Kinds” | David Thomasma called for the development of a medical ethics based squarely on the philosophy of medicine. He recognized, however, that widespread anti-essentialism presented a significant barrier to such an approach. The aim of this article is to introduce a theory that challenges these anti-essentialist objections. ... |
A Single Mass Gathering Resulted in Massive Transmission of COVID-19 Infections in Malaysia with Further International Spread | Malaysia has recorded the highest number of COVID-19 cases in Southeast Asia with more than 35% of new COVID-19 cases linked to the Sri Petaling gathering, a Moslem missionary movement attended by more than 19 000 people of different nationalities, in March 2020 in Kuala Lumpur. From this cluster, 1701 samples have bee... |
Impact of the COVID‐19 pandemic on urological practice in emergency departments in Italy | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the disease it causes, coronavirus disease 2019 (COVID-19), are causing a rapid and tragic health emergency worldwide [1,2]. Italy was the first European country to experience a virus outbreak, starting on Feb, 21st 2020. It resulted in national quara... |
The control of necrotic enteritis in sucking piglets by means of a Clostridium perfringens toxoid vaccine | Abstract Necrotic enteritis in sucking piglets constitutes a serious problem in piglet rearing units because of the high morbidity and mortality associated with the disease. The primary causal agent is Clostridium perfringens type C. The β-toxin plays a decisive role in the pathogenesis of this disease. A toxoid vaccin... |
Myocardial and Microvascular Injury Due to Coronavirus Disease 2019 | Over the past few months, health systems worldwide have been put to the test with the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though the leading clinical manifestations of the SARS-CoV-2 infection involve the respiratory tract, there is a... |
A systematic review of the smartphone applications available for coronavirus disease 2019 (COVID19) and their assessment using the mobile app rating scale (MARS) | The global impact of COVID-19 pandemic has increased the need to rapidly develop and improve utilization of mobile applications across the healthcare continuum to address rising barriers of access to care due to social distancing challenges and allow continuity in sharing of health information, assist with COVID-19 act... |
Biotechnological Potential of Bacteria Isolated from the Sea Cucumber Holothuria leucospilota and Stichopus vastus from Lampung, Indonesia | In order to minimize re-discovery of already known anti-infective compounds, we focused our screening approach on understudied, almost untapped marine environments including marine invertebrates and their associated bacteria. Therefore, two sea cucumber species, Holothuria leucospilota and Stichopus vastus, were collec... |
Global analysis of multi-host and multi-vector epidemic models | Abstract We formulate a multi-group and multi-vector epidemic model in which hosts' dynamics is captured by staged-progression S E I R framework and the dynamics of vectors is captured by an SI framework. The proposed model describes the evolution of a class of zoonotic infections where the pathogen is shared by m host... |
VIP: an integrated pipeline for metagenomics of virus identification and discovery | Identification and discovery of viruses using next-generation sequencing technology is a fast-developing area with potential wide application in clinical diagnostics, public health monitoring and novel virus discovery. However, tremendous sequence data from NGS study has posed great challenge both in accuracy and veloc... |
Call to Action: Preserving and Advocating for Essential Care for Women during the COVID-19 Pandemic | Abstract The COVID-19 pandemic has redefined ‘essential care’, and reproductive healthcare has become a frequently targeted and debated topic. As Obstetricians and Gynecologists (OBGYN), we stand with our patients and others as advocates for women’s reproductive health. With the medical and surgical training to provide... |
A vaccine effective against Zika virus is theoretically possible but may not be delivered anytime soon | Following the first report in May 2015 of the unexpected emergence of Zika in north east Brazil, there has been an explosive epidemic of this infection across Latin America. The outbreak has caused alarm among social and news media as to the virulence and transmission potential of the Aedes mosquito-borne virus. This d... |
Immune responses and pathogenesis of SARS‐CoV‐2 during an outbreak in Iran: Comparison with SARS and MERS | The beginning of 2020 has seen the emergence of COVID‐19, an outbreak caused by a novel coronavirus, SARS‐CoV‐2, an important pathogen for humans. There is an urgent need to better understand this new virus and to develop ways to control its spread. In Iran, the first case of the COVID‐19 was reported after spread from... |
Life Interrupted – On the Front Lines with COVID-19 | [Figure: see text] |
Mesenchymal stem cell (MSc) secretome: A possible therapeutic strategy for intensive-care COVID-19 patients | As an emerging global health challenge, COVID-19 requires international knowledge to reach novel possible therapeutic strategies, especially for intensive-care patients. During the early stages of infection, pneumocytes II are the primary infected cells, harming the respiratory system. We have previous evidence in muri... |
Understanding Covid and the associated post- infectious hyper-inflammatory inflammatory state (PIMS-TS) in children | Summary When SARS-CoV2 infection was first reported from China, very few children had severe lung or systemic disease. Approximately six weeks after the first adult cases were reported in the United Kingdom, a small subgroup of children of largely non-white backgrounds, presented with severe hyper-inflammatory disease,... |
Oropharyngeal candidiasis in hospitalized COVID‐19 Patients from Iran: Species identification and antifungal susceptibility pattern | BACKGROUND: Emergence of coronavirus disease 2019 (COVID‐19) is a major healthcare threat. Apparently, the novel coronavirus (SARS‐CoV‐2) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal candidiasis (OPC) development in COVID‐19 patients with a list of attri... |
Erupción tipo pitiriasis rosada de Gibert en una paciente asintomática con positividad para COVID-19 | |
Volunteering During the Coronavirus Pandemic | |
Design and construction of African swine fever virus chimeras incorporating foreign viral epitopes | In the present work we have studied the feasibility of introducing foreign epitopes into the African swine fever virus (ASFV) particle by genetic manipulation of the virus. For this purpose, we developed specific transfer vectors containing the gene encoding for the highly antigenic structural ASFV protein p54 in which... |
Viral lung infections and the potential for a human pandemic | Abstract Some newly emerging viral lung infections have the potential to cause large outbreaks of severe respiratory disease amongst humans. In this contribution we discuss infections by influenza A (H5N1), SARS and Hanta virus. The H5N1 subtype of avian influenza (bird flu) has crossed the species barrier and causes s... |
Year in review 2013: Acute lung injury, interstitial lung diseases, sleep and physiology | |
Weathering the Cytokine Storm in COVID-19: Therapeutic Implications | BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID-19) and then spread rapidly worldwide. While most individuals remain asymptomatic or develop only mild symptoms, approximately 5% develop severe forms o... |
Solution structure of the pseudoknot of SRV-1 RNA, involved in ribosomal frameshifting 1 1 Edited by I. Tinoco | Abstract RNA pseudoknots play important roles in many biological processes. In the simian retrovirus type-1 (SRV-1) a pseudoknot together with a heptanucleotide slippery sequence are responsible for programmed ribosomal frameshifting, a translational recoding mechanism used to control expression of the Gag-Pol polyprot... |
Noninvasive Positive Pressure Ventilation Treatment for Acute Respiratory Failure in SARS | This study describes the blood gases features and short-term outcomes with noninvasive positive pressure ventilation (NPPV) treatment in the management of acute respiratory failure (ARF) during a severe acute respiratory syndrome (SARS) epidemic. Between April 22 and May 1, 2003, 120 patients meeting clinical criteria ... |
Identification and Survey of a Novel Avian Coronavirus in Ducks | The rapid discovery of novel viruses using next generation sequencing (NGS) technologies including DNA-Seq and RNA-Seq, has greatly expanded our understanding of viral diversity in recent years. The timely identification of novel viruses using NGS technologies is also important for us to control emerging infectious dis... |
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