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COVID-19 Outbreak Among Three Affiliated Homeless Service Sites — King County, Washington, 2020 | On March 30, 2020, Public Health - Seattle and King County (PHSKC) was notified of a confirmed case of coronavirus disease 2019 (COVID-19) in a resident of a homeless shelter and day center (shelter A). Residents from two other homeless shelters (B and C) used shelter A's day center services. Testing for SARS-CoV-2, th... |
‘Africanisation’ of South Africa’s international air links, 1994–2003 | Abstract In the first decade of democratic rule in South Africa scheduled commercial passenger flights across the country’s borders more than doubled. Additional flights served new African air passenger markets and secondary airports in established markets. Overseas flights increased more slowly, serving a diminishing ... |
Identification of VP1 peptides diagnostic of encephalomyocarditis virus from swine | BACKGROUND: Encephalomyocarditis virus (EMCV) can cause myocarditis, respiratory failure, reproductive failure, and sudden death in pre-weaned piglets, which has been isolated in China. EMCV VP1 protein was one of the most important structural proteins and played an important role in the protective immunity. In this st... |
Viral Regulation of RNA Granules in Infected Cells | RNA granules are cytoplasmic, microscopically visible, non-membrane ribo-nucleoprotein structures and are important posttranscriptional regulators in gene expression by controlling RNA translation and stability. TIA/G3BP/PABP-specific stress granules (SG) and GW182/DCP-specific RNA processing bodies (PB) are two major ... |
Serologic Evidence for Influenza C and D Virus among Ruminants and Camelids, Africa, 1991–2015 | Influenza D virus has been identified in America, Europe, and Asia. We detected influenza D virus antibodies in cattle and small ruminants from North (Morocco) and West (Togo and Benin) Africa. Dromedary camels in Kenya harbored influenza C or D virus antibodies, indicating a potential new host for these viruses. |
Editor’s Desk | |
African perspectives: modern complexities of emerging, re-emerging, and endemic zoonoses | |
Vitamin D and Immunity in Infants and Children | The last couple of decades have seen an explosion in our interest and understanding of the role of vitamin D in the regulation of immunity. At the molecular level, the hormonal form of vitamin D signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor. The VDR and vitamin D metaboli... |
Systems Biology Brings Life Sciences Closer: —Report on the China-UK Systems Biology Workshop 2005 | |
Engineering Immunity in the Mammary Gland | The major physiological function of milk is the transport of amino acids, carbohydrates, lipids, and minerals to mammalian offspring. However, milk is also a rich collection of antimicrobial substances, which provide protection against pathogenic infections. These molecules safeguard the integrity of the lactating mamm... |
Characterization of Viral Agents Causing Acute Respiratory Infection in a San Francisco University Medical Center Clinic during the Influenza Season | Background. With use of polymerase chain reaction (PCR) and a centrifugation-enhanced viral culture method, we characterized the viruses causing acute respiratory infection in adults during an influenza season. Methods. During January-March 2002, nasopharyngeal wash specimens from previously healthy adults presenting w... |
Severe Acute Respiratory Syndrome Coronavirus on Hospital Surfaces | Background. Health care workers continued to contract severe acute respiratory syndrome (SARS), even after barrier precautions were widely implemented. Methods. We explored the possible contribution of contaminated hospital surfaces to SARS transmission by swabbing surfaces in 2 hospitals and testing the swab samples b... |
SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression | Since the WHO declared COVID-19 a pandemic, a great effort has been made to understand this serious disease. Thousands of studies are being devoted to understanding its epidemiology, its molecular characteristics, its mechanisms, and the clinical evolution of this viral infection. However, little has been published on ... |
SKEMPI 2.0: An updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation | Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein-protein interactions is crucial to understanding cellular signaling, the assembly and regulation of molecular complexes, the mechanisms through which mutations lead to disease, and prot... |
''Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS‐CoV‐2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID‐19?'' | OBJECTIVE: In this study, we report a large family cluster consisting of 29 genetically related patients hospitalized with COVID‐19. We sought to determine the clinical characteristics relevant to the clinical course of COVID‐19 by comparing the family cluster to unrelated patients with SARS‐CoV‐2 infection so that the... |
Obesity predisposes to the risk of higher mortality in young COVID‐19 patients | BACKGROUND: Although emerging data demonstrated mortality of young COVID‐19 patients, but no data reported the risk factors of mortality for those young patients, and whether obesity is a risk for young COVID‐19 patients remains unknown. METHODS: We conducted a retrospective study including 13 young patients died of CO... |
Covid‐19 and urology | |
Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection | BACKGROUND: Mortality is high among patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. We aimed to determine hospital mortality and the factors associated with it in a cohort of MERS-CoV patients. METHODS: We reviewed hospital records of confirmed cases (detection of virus by polymerase ch... |
RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines | BACKGROUND: Cellular stressors and apoptosis-inducing agents have been shown to induce ribosomal RNA (rRNA) degradation in eukaryotic cells. Recently, RNA degradation in vivo was observed in patients with locally advanced breast cancer, where mid-treatment tumor RNA degradation was associated with complete tumor destru... |
The multifarious roles of heterogeneous ribonucleoprotein A1 in viral infections | Viruses are obligate parasites known to interact with a wide variety of host proteins at different stages of infection. Current antiviral treatments target viral proteins and may be compromised due to the emergence of drug resistant viral strains. Targeting viral‐host interactions is now gaining recognition as an alter... |
Challenges in the Care of IBD Patients During the CoViD-19 Pandemic: Report From a “Red Zone” Area in Northern Italy | |
Prioritization of livestock transboundary diseases in Belgium using a multicriteria decision analysis tool based on drivers of emergence | During the past decade, livestock diseases have (re‐)emerged in areas where they had been previously eradicated or never been recorded before. Drivers (i.e. factors of (re‐)emergence) have been identified. Livestock diseases spread irrespective of borders, and therefore, reliable methods are required to help decision‐m... |
Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates | The ongoing COVID-19 pandemic, caused by infection with SARS-CoV-2, is having a dramatic and deleterious impact on health services and the global economy. Grim public health statistics highlight the need for vaccines that can rapidly confer protection after a single dose and be manufactured using components suitable fo... |
Use of ward closure to control outbreaks among hospitalized patients in acute care settings: a systematic review | BACKGROUND: Though often used to control outbreaks, the efficacy of ward closure is unclear. This systematic review sought to identify studies defining and describing ward closure in outbreak control and to determine impact of ward closure as an intervention on outbreak containment. METHODS: We searched these databases... |
Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt | Infectious bronchitis virus (IBV) causes a major disease problem for the poultry industry worldwide. The currently used live-attenuated vaccines have the tendency to mutate and/or recombine with circulating field strains resulting in the emergence of vaccine-derived variant viruses. In order to circumvent these issues,... |
Angiotensin-converting enzyme 2 and new insights into the renin–angiotensin system | Abstract Components of the renin–angiotensin system are well established targets for pharmacological intervention in a variety of disorders. Many such therapies abrogate the effects of the hypertensive and mitogenic peptide, angiotensin II, by antagonising its interaction with its receptor, or by inhibiting its formati... |
Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada | This paper investigates the commonalities in ethnoveterinary medicine used for horses between Trinidad (West Indies) and British Columbia (Canada). These research areas are part of a common market in pharmaceuticals and are both involved in the North American racing circuit. There has been very little research conducte... |
Stereoselective synthesis of trans-dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety | ABSTRACT: Some new trans-dihydronarciclasine derivatives containing a 1,4-benzodioxane moiety were stereoselectively synthesised using our feasible and efficient method developed recently. These new phenanthridone alkaloid analogues were obtained in both racemic and optically active forms. High enantioselectivities (up... |
Evolution and Variation of the SARS-CoV Genome | Knowledge of the evolution of pathogens is of great medical and biological significance to the prevention, diagnosis, and therapy of infectious diseases. In order to understand the origin and evolution of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus), we collected complete genome sequences of ... |
A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2 | The main protease of SARS-CoV-2 is one of the important targets to design and develop antiviral drugs. In this study, we have selected 40 antiviral phytochemicals to find out the best candidates which can act as potent inhibitors against the main protease. Molecular docking is performed using AutoDock Vina and GOLD sui... |
Different Lineage of Porcine Deltacoronavirus in Thailand, Vietnam and Lao PDR in 2015 | Porcine deltacoronavirus (PDCoV) was detected by RT‐PCR in 12 of 97 (12.4%) intestinal samples collected during 2015 from piglets with diarrhoea in Thailand, Vietnam and Lao PDR. Spike, membrane and nucleocapsid genes were characterized, and phylogenetic analyses demonstrated that PDCoV isolates from Thai and Lao PDR f... |
Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemie(a, b, c): Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und ... | |
Amid conference cancellations, leaders advance with support | In the wake of the COVID‐19 pandemic and in the interest of keeping staff, employees and consumers with mental health and substance use disorders safe, many organizations have had to cancel scheduled conferences and annual meetings. Officials and leaders, meanwhile, are moving forward with helping their members and the... |
Development of a resource modelling tool to support decision makers in pandemic influenza preparedness: The AsiaFluCap Simulator | BACKGROUND: Health care planning for pandemic influenza is a challenging task which requires predictive models by which the impact of different response strategies can be evaluated. However, current preparedness plans and simulations exercises, as well as freely available simulation models previously made for policy ma... |
Interleukin‐18: Biological properties and role in disease pathogenesis | Initially described as an interferon (IFN)γ‐inducing factor, interleukin (IL)‐18 is indeed involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and macrophage activation. IL‐18, a member of the IL‐1 family, is similar to IL‐1β for being processed by caspase 1 to an 18 kDa‐biologically act... |
Persistence of Viruses in Upper Respiratory Tract of Children with Asthma | Abstract Objectives: Nasopharyngeal swabs of 50 asthmatic children in the symptom-free period were examined for the presence of adenoviruses, rhinoviruses and coronaviruses. A control group of 20 healthy individuals was included in this study. Methods: A polymerase chain reaction was used to detect adenovirus DNA and r... |
Lessons learnt from the human infections of avian-origin influenza A H7N9 virus: Live free markets and human health | |
Major Infection Events Over 5 Years: How Is Media Coverage Influencing Online Information Needs of Health Care Professionals and the Public? | BACKGROUND: The last decade witnessed turbulent events in public health. Emerging infections, increase of antimicrobial resistance, deliberately released threats and ongoing battles with common illnesses were amplified by the spread of disease through increased international travel. The Internet has dramatically change... |
Probiotics and COVID-19 – Authors' reply | |
Molecular cloning, expression, purification and crystallographic analysis of PRRSV 3CL protease | 3CL protease, a viral chymotrypsin-like proteolytic enzyme, plays a pivotal role in the transcription and replication machinery of many RNA viruses, including porcine reproductive and respiratory syndrome virus (PRRSV). In this study, the full-length 3CL protease from PRRSV was cloned and overexpressed in Escherichia c... |
Dental and medical collaboration during COVID‐19 | |
Performance of pigs kept under different sanitary conditions affected by protein intake and amino acid supplementation(,)(2) | There is growing evidence that requirements for particular AA increase when pigs are kept under low sanitary conditions. The extent to which reduction in growth performance is related to these increased requirements is unclear. To evaluate this relationship, an experiment (2 × 2 × 2 factorial arrangement) was performed... |
Etiology and Incidence of Viral and Bacterial Acute Respiratory Illness among Older Children and Adults in Rural Western Kenya, 2007–2010 | BACKGROUND: Few comprehensive data exist on disease incidence for specific etiologies of acute respiratory illness (ARI) in older children and adults in Africa. METHODOLOGY/PRINCIPAL FINDINGS: From March 1, 2007, to February 28, 2010, among a surveillance population of 21,420 persons >5 years old in rural western Kenya... |
Incidence of Circulating Antibodies Against Hemagglutinin of Influenza Viruses in the Epidemic Season 2013/2014 in Poland | The aim of this study was to determine the level of antibodies against hemagglutinin of influenza viruses in the sera of people in different age groups in the epidemic season 2013/2014 in Poland. The level of anti-hemagglutinin antibodies was determined by hemagglutination inhibition test (HAI). A total number of 1,050... |
Association of targeted multiplex PCR with resequencing microarray for the detection of multiple respiratory pathogens | A large number of viral and bacterial organisms are responsible for community-acquired pneumonia (CAP) which contributes to substantial burden on health management. A new resequencing microarray (RPM-IVDC1) associated with targeted multiplex PCR was recently developed and validated for multiple respiratory viruses dete... |
Chapter 8 In vivo experimental models of infection and disease | Abstract Human and animal models continue to play a crucial role in research to understand host immunity to rhinovirus (RV) and identify disease mechanisms. Human models have provided direct evidence that RV infection is capable of exacerbating chronic respiratory diseases and identified immunological processes that co... |
Disruption of joint arthroplasty services in Europe during the COVID-19 pandemic: an online survey within the European Hip Society (EHS) and the European Knee Associates (EKA) | PURPOSE: The aim of the present study was to evaluate the impact of the coronavirus (COVID-19) pandemic on joint arthroplasty service in Europe by conducting an online survey of arthroplasty surgeons. METHODS: The survey was conducted in the European Hip Society (EHS) and the European Knee Associates (EKA). The survey ... |
Procédure de dépistage d’une infection à COVID-19 en milieu de travail structuré africain | Résumé Alors qu’il n’existe de recommandation spécifique en Afrique Subsaharienne, le but de ce travail est de proposer aux professionnels de santé, un outil simple de détection des cas de COVID-19 parmi les travailleurs du secteur formel dans cette région. En effet la riposte contre l’infection à COVID-19 en milieu de... |
Examining the relationship between infectious diseases and flooding in Europe: A systematic literature review and summary of possible public health interventions | Introduction Many infectious diseases are sensitive to climatic changes; specifically, flooding. This systematic literature review aimed to strengthen the quality and completeness of evidence on infectious diseases following flooding, relevant to Europe. Methods A systematic literature review from 2004–2012 was perform... |
Molecular epidemiology of circulating human coronaviruses in children at a tertiary hospital in Catalonia (Spain) from 2014 to 2016 | |
IL‐4 induces a suppressive IL‐10‐producing CD8(+) T cell population via a Cdkn2a‐dependent mechanism | CD8(+) T cells play an important role in immune regulation and effective immune responses against tumor cells, viral infection, and intracellular pathogens. In this report, using tiger or 10BiT mice, we defined a population of IL‐10‐producing CD8(+) T cells that were induced by IL‐4. These IL‐10(+)CD8(+) T cells posses... |
Humoral innate immune response and disease | The humoral innate immune response consists of multiple components, including the naturally occurring antibodies (NAb), pentraxins and the complement and contact cascades. As soluble, plasma components, these innate proteins provide key elements in the prevention and control of disease. However, pathogens and cells wit... |
An Open Question: Is It Rational to Inhibit the mTor-Dependent Pathway as COVID-19 Therapy? | |
Pour une prise en charge préventive de la maladie d’Alzheimer | Résumé Les démences et la maladie d’Alzheimer (MA), en particulier, vont devenir de plus en plus un enjeu de santé publique. Trois données importantes peuvent cependant modifier le poids de ces pathologies : (1) de simples mesures d’hygiène de vie (contrôle de facteurs de risque vasculaire, activité physique et stimula... |
Small business loan eligibility promising for nonprofits | Nonprofit organizations receiving Medicaid payments are encouraged that they are now eligible for small business loans courtesy of the $2 trillion COVID‐19 relief package (see story, beginning on page 1). Just a few short weeks ago, in an earlier version of the legislation, mental health providers with Medicaid‐partici... |
Serum LD1 isoenzyme and blood lymphocyte subsets as prognostic indicators for severe acute respiratory syndrome | Background. The pathophysiology of severe acute respiratory syndrome (SARS) is at present poorly understood, but advanced age and serum total lactate dehydrogenase (LD) activity >300 U L(−1) have been associated with adverse clinical outcomes. Blood leucocytes and lymphocyte subsets were reported to decrease, respectiv... |
COVID-19 cancer conundrum—evidence driving decisions or the lack of it? | |
Macrophage Coordination of the Interferon Lambda Immune Response | Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation and fibrosis in viral and non-viral diseases. Here we demonstrate that macrophages are primary responders to IFN-λ, un... |
Evolutionary rate shifts suggest species-specific adaptation events in HIV-1 and SIV | The process of molecular adaptation following a cross-species virus transmission event is currently poorly understood. Here, we identified 137 protein sites that experienced deceleration in their rate of evolution along the HIV-1/SIV phylogeny, likely indicating gain-of-function and consequent adaptation. The majority ... |
Early loss of astrocytes in herpes simplex virus–induced central nervous system demyelination | Immunohistochemistry was used to study herpes simplex virus type 1–induced central nervous system demyelination in the trigminal root entry zone of mice inoculated with herpes simplex virus type 1 by the corneal route. There was no change in peripheral nervous system myelin as shown by immunostaining for Po glycoprotei... |
The role of viruses in the aetiology of IRA in Peruvian children | |
Severe psychological distress among patients with epilepsy during the COVID‐19 outbreak in southwest China | OBJECTIVE: To compare the severity of psychological distress between patients with epilepsy and healthy controls during the COVID‐19 outbreak in southwest China, as well as identify potential risk factors of severe psychological distress among patients with epilepsy. METHODS: This cross‐sectional case‐control study exa... |
The challenge of COVID‐19 has accelerated the use of new data‐sharing technologies | |
On-Site Wastewater Treatment | Human waste may contain high numbers of a variety of enteric pathogens. Diseases caused by these microorganisms include gastroenteritis, infectious hepatitis, cholera, typhoid, respiratory illness, myocarditis, encephalitis, and endocarditis. When this waste is treated in an on-site wastewater treatment system, such as... |
Ethical dilemmas due to the Covid-19 pandemic | The devastating pandemic that has stricken the worldwide population induced an unprecedented influx of patients in ICUs, raising ethical concerns not only surrounding triage and withdrawal of life support decisions, but also regarding family visits and quality of end-of-life support. These ingredients are liable to sha... |
Immunomodulation for the Management of Corona Virus Disease (COVID-19) | |
Characterization of cytotoxic T‐lymphocyte epitopes and immune responses to SARS coronavirus spike DNA vaccine expressing the RGD‐integrin‐binding motif | Integrins are critical for initiating T‐cell activation events. The integrin‐binding motif Arg‐Gly‐Asp (RGD) was incorporated into the pcDNA 3.1 mammalian expression vector expressing the codon‐optimized extracellular domain of SARS coronavirus (SARS‐CoV) spike protein, and tested by immunizing C57BL/6 mice. Significan... |
Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With The Guidelines-Resuscitation Adult and Pediatric Task Forces of the American Heart Association | N/A. |
Nonstructural protein 6 of porcine epidemic diarrhea virus induces autophagy to promote viral replication via the PI3K/Akt/mTOR axis | Abstract Porcine epidemic diarrhea virus (PEDV) has caused, and continues to cause, severe economic losses to the swine industry worldwide. The pathogenic mechanism and immune regulatory interactions between PEDV and the host remain largely unknown. In this study, the interaction between autophagy and PEDV replication ... |
The Challenges of COVID-19 for People Living With Diabetes: Considerations for Digital Health | The coronavirus disease (COVID-19) is a global pandemic that significantly impacts people living with diabetes. Diabetes-related factors of glycemic control, medication pharmacodynamics, and insulin access can impact the severity of a COVID-19 infection. In this commentary, we explore how digital health can support the... |
Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus | Fecal virus shedding, seroconversion and histopathology were evaluated in 3-7-year-old gnotobiotic calves orally inoculated with porcine deltacoronavirus (PDCoV) (9.0-9.6 log(10) genomic equivalents [GE] of OH-FD22-P5; n=4) or porcine epidemic diarrhea virus (PEDV) (10.2-12.5 log(10) GE of PC21A; n=3). In PDCoV-inocula... |
Letter to the Editor: COVID‐19‐Related Liver Injury and Clinical Outcomes: Does It Really Exist? | We read with interest the study by Lei and colleagues on the association between markers of liver injury and mortality in coronavirus disease 2019 (COVID‐19) in China. The authors have painstakingly collated data from a large number of COVID‐19 patients from multiple centers across Wuhan. They found that an increase in... |
Quantitative EEG markers to Prognosticate Critically ill Patients with COVID-19: A Retrospective Cohort Study | |
Nanoparticulate systems as drug carriers: the need | Development of nanoparticles for drug delivery has progressed by leaps and bounds over the last few decades, facilitating the possibility of an efficacious therapy for some fatal diseases. This development has stemmed from either the unsuitable physicochemical characteristics of the existing drug molecules, such as lim... |
Influenza Aerosols in UK Hospitals during the H1N1 (2009) Pandemic – The Risk of Aerosol Generation during Medical Procedures | BACKGROUND: Nosocomial infection of health-care workers (HCWs) during outbreaks of respiratory infections (e.g. Influenza A H1N1 (2009)) is a significant concern for public health policy makers. World Health Organization (WHO)-defined ‘aerosol generating procedures’ (AGPs) are thought to increase the risk of aerosol tr... |
Adaptations de la prise en charge des patients en Nutrition Artificielle à Domicile au cours de l’épidémie virale COVID-19 en France: avis du Comité de Nutrition à Domicile de la Société Francophone de Nutrition Clinique et Métabolisme (SFNCM) | Résumé La nutrition artificielle à domicile, entérale ou parentérale, s’adresse à des malades chroniques fragiles. La situation actuelle de pandémie COVID-19 peut compromettre leur prise en charge à plusieurs niveaux : difficultés d’accès aux établissements de santé largement réorientés vers la prise en charge des mala... |
Inhibition of Influenza H7 Hemagglutinin-Mediated Entry | The recent outbreak of H7N9 influenza in China is of high concern to public health. H7 hemagglutinin (HA) plays a critical role in influenza entry and thus HA presents an attractive target for antivirals. Previous studies have suggested that the small molecule tert-butyl hydroquinone (TBHQ) inhibits the entry of influe... |
Bordetella Pertussis Infection in Hospitalized Infants with Acute Bronchiolitis | OBJECTIVE: To assess the frequency of B. pertussis infection among young infants hospitalized with acute bronchiolitis and to determine whether B. pertussis infection affects the clinical course of acute bronchiolitis. METHODS: A total of 172 infants <6 months of age hospitalized with acute bronchiolitis were tested fo... |
Burden of Illness in UK Subjects with Reported Respiratory Infections Vaccinated or Unvaccinated against Influenza: A Retrospective Observational Study | OBJECTIVE: Detailed data are lacking on influenza burden in the United Kingdom (UK). The objective of this study was to estimate the disease burden associated with influenza-like illness (ILI) in the United Kingdom stratified by age, risk and influenza vaccination status. METHODS: This retrospective, cross-sectional, e... |
Direct oral anticoagulant plasma levels’ striking increase in severe COVID‐19 respiratory syndrome patients treated with antiviral agents: The Cremona experience | BACKGROUND: Antiviral drugs are administered in patients with severe COVID‐19 respiratory syndrome, including those treated with direct oral anticoagulants (DOACs). Concomitant administration of antiviral agents has the potential to increase their plasma concentration. A series of patients managed in the Cremona Thromb... |
Covid-19 palaver: Ending rights violations of vulnerable groups in Africa | This letter amplifies the rising spate of human rights violations exacerbated by the COVID-19 pandemic in Africa. It notes that while governments in the region have declared restrictions on social gathering, in a bid to curtail the deadly disease, violations of human rights of vulnerable groups by State security operat... |
A global-scale ecological niche model to predict SARS-CoV-2 coronavirus infection rate | COVID-19 pandemic is a global threat to human health and economy that requires urgent prevention and monitoring strategies. Several models are under study to control the disease spread and infection rate and to detect possible factors that might favour them, with a focus on understanding the correlation between the dis... |
Viral disease emergence in shrimp aquaculture: origins, impact and the effectiveness of health management strategies | Shrimp aquaculture has grown rapidly over several decades to become a major global industry that serves the increasing consumer demand for seafood and has contributed significantly to socio‐economic development in many poor coastal communities. However, the ecological disturbances and changes in patterns of trade assoc... |
Use of Obstetric Practice Web Sites to Distribute Zika Virus Information to Pregnant Women During a Zika Virus Outbreak | OBJECTIVE: To describe the current use of obstetric practice Web sites to disseminate Zika virus information to patients. DESIGN: Review of 913 randomly selected practice Web sites and associated social media accounts in January and August 2016. SETTING: Obstetric practice Web sites and associated social media accounts... |
Renin-Angiotensin-System (RAS) und COVID-19 – Zur Verordnung von RAS-Blockern | Twenty years ago, an enzyme homologous to the previously known angiotensin-converting enzyme (ACE) was identified, and subsequently named ACE2. In the renin-angiotensin system (RAS), ACE2 has counter-regulatory functions against the classical effector peptide angiotensin II, for example in blood pressure regulation and... |
Our challenge is to adapt the organization of our system to the six stages of the epidemic to go beyond the COVID‐19 crisis | |
Giant Retroperitoneal Hematoma during Extracorporeal Membrane Oxygenation in a Patient with 2019-Coronavirus Pneumonia | |
Evolutionary longitudinal network dynamics of global zoonotic research | At global and local levels, we are observing an increasing range and rate of disease outbreaks that show evidence of jumping from animals to humans, and from food to humans. Zoonotic infections (i.e. Hendra, swine flu, anthrax) affect animal health and can be deadly to humans. The increasing rate of outbreaks of infect... |
The close relationship between sudden loss of smell and COVID-19 | Abstract Introduction The real number of COVID-19 cases may be underestimated since several countries have difficulty offering laboratory tests for all the population. Therefore, finding a symptom with a high predictive value would help in diagnostic and isolation strategies. Objective To correlate the sudden loss of t... |
Human Enterovirus Nonstructural Protein 2C(ATPase) Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone | RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism. Although some virus-encoded RNA helicases/chaperones have been predicted or identified, their RNA remodeling ac... |
Parasitosis (I). Lesiones cardiacas y pulmonares importadas | Imported parasitoses are an uncommon condition in our setting, although recently, the increase of migratory flow has been leading to an increase in the detected cases of these diseases. This fundamentally occurs in immigrants from tropical zones where these conditions are generally endemic. However, imported parasitose... |
One‐lung ventilation during the COVID‐19 pandemic | |
Covid-19 in India: Post-Lockdown scenarios and provisioning for healthcare | |
Preventing Suicide in Rural Communities During the COVID‐19 Pandemic | |
Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers | Abstract Objective We compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs). Methods A cluster randomized clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCW... |
Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans | A large number of human genes associated with viral infections contain single nucleotide polymorphisms (SNPs), which represent a genetic variation caused by the change of a single nucleotide in the DNA sequence. SNPs are located in coding or non-coding genomic regions and can affect gene expression or protein function ... |
Imaging of Emerging Infectious Diseases | PURPOSE OF REVIEW: Emerging infectious diseases have seen a record increase in prevalence, and understanding their management is critical in an increasingly global community. In this paper, we review current literature detailing the role of radiology in the diagnosis and treatment of the Ebola (EVD), Zika (ZVD), Chikun... |
Communication Skills in the Age of COVID-19 | COVID-19 has placed enormous stress on hospitals and health care providers worldwide. Limitations in hospital capacity may result in difficult decisions in how life-sustaining technologies are allocated among patients. The authors of this essay provide guidance on how to communicate with patients who are seriously ill ... |
Can Lower Remittance Costs Improve Human Capital Accumulation in Africa? | To evaluate gains in human capital accumulation from reduction in remittance prices, this study constructs a general equilibrium model in which the choices to invest in human capital and to migrate are endogenous. The model is calibrated for a group of eight African economies which offer student loans, and the effect o... |
Full-length genomic characterization and molecular evolution of canine parvovirus in China | Canine parvovirus type 2 (CPV-2) can cause acute haemorrhagic enteritis in dogs and myocarditis in puppies. This disease has become one of the most serious infectious diseases of dogs. During 2014 in China, there were many cases of acute infectious diarrhoea in dogs. Some faecal samples were negative for the CPV-2 anti... |
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