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One Academic Health System’s Early (and Ongoing) Experience Responding to COVID-19: Recommendations From the Initial Epicenter of the Pandemic in the United States | On January 19, 2020, the first case of a patient with coronavirus disease 2019 (COVID-19) in the United States was reported in Washington State. On February 29, 2020, a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) passed away in a hospital in Seattle-King County, the first reported... |
MERS Coronavirus Neutralizing Antibodies in Camels, Eastern Africa, 1983–1997 | To analyze the distribution of Middle East respiratory syndrome coronavirus (MERS-CoV)–seropositive dromedary camels in eastern Africa, we tested 189 archived serum samples accumulated during the past 30 years. We identified MERS-CoV neutralizing antibodies in 81.0% of samples from the main camel-exporting countries, S... |
Children may be less affected than adults by novel coronavirus (COVID‐19) | |
Interactions of Dimethylarsinic Acid, Total Arsenic and Zinc Affecting Rice Crop Management and Human Health in Cambodia | BACKGROUND. In parts of Cambodia and in many other parts of the world, irrigation of rice with groundwater results in arsenic (As) accumulation in soil and rice, leading to health concerns associated with rice consumption. At times, some As is present as relatively nontoxic, non-regulated, dimethylarsinic acid (DMA). L... |
mRNA maturation in giant viruses: variation on a theme | Giant viruses from the Mimiviridae family replicate entirely in their host cytoplasm where their genes are transcribed by a viral transcription apparatus. mRNA polyadenylation uniquely occurs at hairpin-forming palindromic sequences terminating viral transcripts. Here we show that a conserved gene cluster both encode t... |
Mortality among dentists in Taiwan, 1985–2009 | Background/Purpose Controversy exists in the literature regarding whether dentists with multiple occupational exposures suffer from premature mortality. A cohort mortality study was conducted to evaluate the survival outcome and determine if potential exposure to harmful agents leads to premature mortality among dentis... |
Chapter 12 Clinical Trials of Vaccines for Biodefense and Emerging and Neglected Diseases | Abstract The development of safe and effective vaccines for the prevention and control of emerging and neglected infectious diseases is an international priority, as is the development of similar control measures for bioterrorist threats. International standards have been established to ensure the protection of human s... |
Molecular detection of viruses in Kenyan bats and discovery of novel astroviruses, caliciviruses and rotaviruses | This is the first country-wide surveillance of bat-borne viruses in Kenya spanning from 2012–2015 covering sites perceived to have medium to high level bat-human interaction. The objective of this surveillance study was to apply a non-invasive approach using fresh feces to detect viruses circulating within the diverse ... |
Construction and Characterization of Single-Chain Variable Fragment Antibody Library Derived from Germline Rearranged Immunoglobulin Variable Genes | Antibody repertoires for library construction are conventionally harvested from mRNAs of immune cells. To examine whether germline rearranged immunoglobulin (Ig) variable region genes could be used as source of antibody repertoire, an immunized phage-displayed scFv library was prepared using splenocytic genomic DNA as ... |
Single stranded (ss)RNA-mediated antiviral response against infectious laryngotracheitis virus infection | BACKGROUND: Single stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, synthetic ssRNA analog, resiquimod, has been shown to elicit antiviral response against infectious bu... |
Death anxiety in the time of COVID-19: theoretical explanations and clinical implications | The recent COVID-19 pandemic has triggered a surge in anxiety across the globe. Much of the public’s behavioural and emotional response to the virus can be understood through the framework of terror management theory, which proposes that fear of death drives much of human behaviour. In the context of the current pandem... |
Coping with being cooped up: Social distancing during COVID-19 among 60+ in the United States | OBJECTIVES. This study examined the impact of sheltering in place and social distancing among adults aged 60 and older during the 2020 outbreak of COVID-19 in the United States. METHODS. Using convenience sampling respondents were asked to complete a web-administered survey to explore impact of social distancing on lon... |
Tuberculosis prevention in healthcare workers in China 10 years after the severe acute respiratory syndrome pandemic | BSL3 and respiratory isolation wards protect healthcare workers from nosocomial TB infection in China http://ow.ly/PGvSl |
Burden of Human Metapneumovirus Infections in Cancer Patients: Risk Factors and Outcomes | BACKGROUND: Human metapneumovirus (hMPV) causes upper and lower respiratory tract infections (URI and LRI, respectively) in healthy and immunocompromised patients; however, its clinical burden in patients with cancer remains unknown. METHODS: In a retrospective study of all laboratory-confirmed hMPV infections treated ... |
12 IBCs – A cornerstone of public trust in research | Abstract For four decades the NIH Guidelines have served as the framework for the oversight of research with recombinant and synthetic nucleic acid molecules. IBCs are a vital component in that system of oversight as the entity that ensures the safe conduct of this type of research at the local level. IBC review also p... |
Autoantibodies against human epithelial cells and endothelial cells after severe acute respiratory syndrome (SARS)‐associated coronavirus infection | The severe acute respiratory syndrome (SARS) is caused by infection with the SARS‐associated coronavirus (SARS‐CoV) and characterized by severe pulmonary inflammation and fibrosis. In this study, the development of autoantibodies against human epithelial cells and endothelial cells in patients with SARS at different ti... |
Tackling the COVID-19 challenge—a view from the DOJ | |
Immune checkpoint inhibitors: A physiology-driven approach to the treatment of COVID-19 | While confirmed cases of infections of the deadly coronavirus disease 2019 (COVID-19) have exceeded 4.7 million globally, scientists are pushing forward with efforts to develop vaccines and treatments in an attempt to slow the pandemic and lessen the disease’s damage. Although no proven effective therapies to treat COV... |
COVID-19 serial interval estimates based on confirmed cases in public reports from 86 Chinese cities | As a novel coronavirus (COVID-19) continues to spread widely and claim lives worldwide, its transmission characteristics remain uncertain. Here, we present and analyze the serial intervals–the time period between the onset of symptoms in an index (infector) case and the onset of symptoms in a secondary (infectee) case–... |
Where have the gatherings gone? Reweaving the social fabric in the time of pandemic and interpersonal distancing | |
Studying Communication Problems for Emergency Management of SARS and H7N9 in China | BACKGROUND: Severe Acute Respiratory Syndrome (SARS) and Influenza A virus Subtype H7N9 (H7N9) have both had a great impact on China in the 21(st) century, causing significant negative impacts on health, the economy, and even global security. The control efforts for SARS were heavily criticized, the H7N9 response, 10 y... |
ABSL-4 Aerobiology Biosafety and Technology at the NIH/NIAID Integrated Research Facility at Fort Detrick | The overall threat of a viral pathogen to human populations is largely determined by the modus operandi and velocity of the pathogen that is transmitted among humans. Microorganisms that can spread by aerosol are considered a more challenging enemy than those that require direct body-to-body contact for transmission, d... |
Chapter 61 Mucosal Veterinary Vaccines: Comparative Vaccinology | |
Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection | Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk associati... |
The invention of the swine-flu pandemic | |
The UNITAID Patent Pool Initiative: Bringing Patents Together for the Common Good | Developing and delivering appropriate, affordable, well-adapted medicines for HIV/AIDS remains an urgent challenge: as first-line therapies fail, increasing numbers of people require costly second-line therapy; one-third of ARVs are not available in pediatric formulations; and certain key first- and second-line triple ... |
Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou | Human coronavirus (HCoV) is one of the most common causes of respiratory tract infection throughout the world. To investigate the epidemiological and genetic variation of HCoV in Guangzhou, south China, we collected totally 13048 throat and nasal swab specimens from adults and children with fever and acute upper respir... |
PERNIOSIS DEL CONFINAMIENTO, UNA VIEJA CONOCIDA EN EL CONTEXTO DEL COVID-19 | |
RNA Modifications Modulate Activation of Innate Toll-Like Receptors | Self/foreign discrimination by the innate immune system depends on receptors that identify molecular patterns as associated to pathogens. Among others, this group includes endosomal Toll-like receptors, among which Toll-like receptors (TLR) 3, 7, 8, and 13 recognize and discriminate mammalian from microbial, potentiall... |
Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies | Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen-specific B cell proliferation, differentiation of B cells into plasma cells... |
The impact of COVID-19 on the degree of dependence and structure of risk-return relationship: A quantile regression approach | This paper examines the impact of the novel coronavirus (COVID-19) on the degree and structure of risk-return dependence in the US. The results from quantile regression (QR) indicate a left-tailed asymmetric dependence structure of sectoral returns with market portfolio. Following the COVID-19 outbreak, degree of depen... |
COVID-19 pandemic in Panama: lessons of the unique risks and research opportunities for Latin America | The Republic of Panama has the second most unequally distributed wealth in Central America, has recently entered the list of countries affected by the COVID-19 pandemic, and has one of the largest testing rate per inhabitant in the region and consequently the highest incidence rate of COVID-19, making it an ideal locat... |
Advances of bioinformatics tools applied in virus epitopes prediction | In recent years, the in silico epitopes prediction tools have facilitated the progress of vaccines development significantly and many have been applied to predict epitopes in viruses successfully. Herein, a general overview of different tools currently available, including T cell and B cell epitopes prediction tools, i... |
SARS CoV‐2 aggravates cellular metabolism mediated complications in COVID‐19 infection | |
Case-Fatality Risk Estimates for COVID-19 Calculated by Using a Lag Time for Fatality | We estimated the case-fatality risk for coronavirus disease cases in China (3.5%); China, excluding Hubei Province (0.8%); 82 countries, territories, and areas (4.2%); and on a cruise ship (0.6%). Lower estimates might be closest to the true value, but a broad range of 0.25%–3.0% probably should be considered. |
COVID‐19 and the use of immunomodulatory and biologic agents for severe cutaneous disease: An Australian/New Zealand consensus statement | Patients on immunomodulators, including biologic agents and new small molecular inhibitors, for cutaneous disease, represent a potentially vulnerable population during the COVID‐19 pandemic. There is currently insufficient evidence to determine whether patients on systemic immunomodulators are at increased risk of deve... |
In vivo gene delivery mediated by non-viral vectors for cancer therapy | Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be ... |
Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis | OBJECTIVE: To illuminate the pathophysiology of acute rhinosinusitis (ARS) with sequential monitoring of inflammatory biomarkers during an ARS episode and to clarify their diagnostic usability in bacterial ARS. STUDY DESIGN: Inception cohort study with 50 conscripts with ARS. METHODS: We collected peripheral blood high... |
Encuesta nacional sobre el tratamiento de la apendicitis aguda en España durante la fase inicial de la pandemia COVID-19 | Resumen INTRODUCCIÓN: La pandemia COVID-19 ha tenido una importante repercusión en los hospitales españoles, que han tenido que destinar todos los recursos disponibles al tratamiento de estos pacientes, reduciendo la capacidad de atender otras patologías habituales. Este estudio pretende analizar cómo se ha visto afect... |
Concerns about Misinterpretation of Recent Scientific Data Implicating Dromedary Camels in Epidemiology of Middle East Respiratory Syndrome (MERS) | |
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection | Sex differences in the incidence and severity of respiratory virus infection are widely documented in humans and murine models and correlate with sex biases in numbers and/or functional responses of innate immune cells in homeostasis and lung infection. Similarly, changes in sex hormone levels upon puberty, pregnancy, ... |
Scientific research progress of COVID‐19/SARS‐CoV‐2 in the first five months | A cluster of pneumonia (COVID‐19) cases have been found in Wuhan China in late December, 2019, and subsequently, a novel coronavirus with a positive stranded RNA was identified to be the aetiological virus (severe acute respiratory syndrome coronavirus 2, SARS‐CoV‐2), which has a phylogenetic similarity to severe acute... |
Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis | BACKGROUND: The clinical relevance of parallel detection of multiple viruses by real‐time polymerase chain reaction (RT‐PCR) remains unclear. This study evaluated the association between the detection of multiple viruses by RT‐PCR and disease severity in children with bronchiolitis. METHODS: Children less than 2 years ... |
Acute fibrinous and organizing pneumonia | A 45-year-old man presented with malaise, arthralgia, and dyspnea. The chest CT scan showed bilateral patchy consolidation in the lower lobes. A lung biopsy revealed intra-alveolar fibrin “balls” deposits and focal features of organizing pneumonia, both of which are typical pathological features of acute fibrinous and ... |
Gain-of-Function Research and the Relevance to Clinical Practice | The ongoing moratorium on gain-of-function (GOF) research with highly pathogenic avian influenza virus, severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome coronavirus has drawn attention to the current debate on these research practices and the potential benefits and risks they present.... |
Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines | Food-grade Lactic Acid Bacteria (LAB) have been safely consumed for centuries by humans in fermented foods. Thus, they are good candidates to develop novel oral vectors, constituting attractive alternatives to attenuated pathogens, for mucosal delivery strategies. Herein, this review summarizes our research, up until n... |
Playing the Cards We are Dealt: Covid‐19 and Nursing Homes | |
Detection of bat hepatitis E virus RNA in microbats in Japan | Several recent studies have reported that various bat species harbor bat hepatitis E viruses (BatHEV) belonging to the family Hepeviridae, which also contains human hepatitis E virus (HEV). The distribution and ecology of BatHEV are not well known. Here, we collected and screened 81 bat fecal samples from nine bat spec... |
Asma infantil | El asma es la enfermedad crónica infantil más frecuente. El diagnóstico es fácil en la mayoría de las ocasiones por la aparición de episodios de disnea espiratoria con sibilancias reversibles espontáneamente o por el efecto de broncodilatadores. En el momento del diagnóstico, se requieren tres pruebas complementarias: ... |
Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study | Abstract Objectives To determine the viral epidemiology and clinical characteristics of patients with and without clinically apparent respiratory tract infection. Methods This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) ... |
Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside? | One year after the occurrence of the first case of infection by the Middle East Respiratory Syndrome coronavirus (MERS-CoV) there is no clear consensus on the best treatment to propose. The World Health Organization, as well as several other national agencies, are still working on different clinical approaches to imple... |
Asymptomatic Spread of COVID-19 in 97 Patients at a Skilled Nursing Facility | Summary This point-prevalence investigation of all residents at a single nursing home found a 54% infection rate in this reportedly asymptomatic population. Prior to testing no confirmed or suspected cases had been reported. |
The National Gene Vector Biorepository's Pharm/Tox Database | |
Low prevalence and disease severity of COVID‐19 in post‐liver transplant recipients—A single centre experience | Coronavirus disease 2019 (COVID‐19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high‐risk cohort. The following is a short report on COVID‐19 in liver transplant recipients (n = 5)... |
Essential Family Caregivers in Long-term Care during the COVID-19 Pandemic | Brief Summary: In the months stretching out ahead of us in the prevention of COVID-19, we must keep our residents safe from the risk of circulating virus, but we also must promote person-centered geriatric care allowing family presence as essential care partners. |
Closed-type pre-treatment device for point-of-care testing of sputum | The procedures and protocols for the pre-treatment of sputum specimens, mainly used for the diagnosis of pneumonia, are complex, labor intensive, and require skilled specialists working in a biosafety containment laboratory because of sample infectivity. In this study, we developed the first portable, low-power pre-tre... |
PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study | BACKGROUND: Viral respiratory tract infection is the most frequent cause of acute cough and is reported at onset in about one third of patients with chronic cough. Persistent infection is therefore one possible explanation for the cough reflex hypersensitivity and pulmonary inflammation reported in chronic cough patien... |
Pre-outbreak determinants of perceived risks of corona infection and preventive measures taken. A prospective population-based study | OBJECTIVES: Assess how people perceive the risks of coronavirus infection, whether people take preventive measures, and which pre-outbreak factors contribute to the perceived risks and measures taken, such as pre-outbreak respiratory problems, heart problems, diabetes, anxiety and depression symptoms, loneliness, age, ... |
Evolving Understanding of the Causes of Pneumonia in Adults, With Special Attention to the Role of Pneumococcus | Before 1945, Streptococcus pneumoniae caused more than 90% of cases of pneumonia in adults. After 1950, the proportion of pneumonia caused by pneumococcus began to decline. Pneumococcus has continued to decline; at present, this organism is identified in fewer than fewer10%–15% of cases. This proportion is higher in Eu... |
COVID-19: impact by and on the environment, health and economy | |
The negative impact of the COVID-19 lockdown on pain and physical function in patients with end-stage hip or knee osteoarthritis | PURPOSE: The purpose of this study was to evaluate pain, functional impairment, mental health, and daily activity in patients with end-stage hip and knee osteoarthritis (OA) during the COVID-19 lockdown. METHODS: The study included 63 patients, with hip or knee OA, who had been scheduled for arthroplasty that was postp... |
The relatively young and rural population may limit the spread and severity of COVID-19 in Africa: a modelling study | INTRODUCTION: A novel coronavirus disease 2019 (COVID-19) has spread to all regions of the world. There is great uncertainty regarding how countries’ characteristics will affect the spread of the epidemic; to date, there are few studies that attempt to predict the spread of the epidemic in African countries. In this pa... |
Developing an automated mechanism to identify medical articles from Wikipedia for knowledge extraction | Wikipedia contains rich biomedical information that can support medical informatics studies and applications. Identifying the subset of medical articles of Wikipedia has many benefits, such as facilitating medical knowledge extraction, serving as a corpus for language modeling, or simply making the size of data easy to... |
Reorganising the emergency department to manage the COVID-19 outbreak | BACKGROUND: The COVID-19 disease outbreak that first surfaced in Wuhan, China, in December 2019, has taken the world by storm and ravaged almost every country in the world. Emergency departments (ED) in hospitals are on the frontlines, serving an essential function in identifying these patients, isolating them early wh... |
Ebola Virus Epidemiology and Evolution in Nigeria | Containment limited the 2014 Nigerian Ebola virus (EBOV) disease outbreak to 20 reported cases and 8 fatalities. We present here clinical data and contact information for at least 19 case patients, and full-length EBOV genome sequences for 12 of the 20. The detailed contact data permits nearly complete reconstruction o... |
Effects of Luteolin on the Proliferation of Rat Lung Fibroblasts | Abstract Aim To approach the effects of luteolin on proliferation of rat lung fibroblasts. Methods The lung fibroblasts were isolated from the lungs of Sprague-Dawley rats at postnatal day 3, and were then passaged to 96-well culture plates. All cells were divide into 6 groups including normal control group, positive c... |
Antibacterial bioactive materials | Bioactive materials with antibacterial properties have significant medical interest. Antibacterial bioactive materials can be prepared by simple combination of antibacterial substances with materials such as hydrogels, ceramics, metals, and polymers, in different forms, such as fibres, foams, films or gels. The deliver... |
Connected at Sea: The Influence of the Internet and Online Communication on the Well-Being and Life Satisfaction of Cruise Ship Employees | This study aims to elucidate the idiosyncratic effects of the Internet and online communication on the well-being and life satisfaction of cruise ship employees. Cross-sectional surveys and covariance-based structural equation modelling tools were used. In addition, univariate variance analysis was used to address the ... |
Household Materials Selection for Homemade Cloth Face Coverings and Their Filtration Efficiency Enhancement with Triboelectric Charging | [Image: see text] The COVID-19 pandemic is currently causing a severe disruption and shortage in the global supply chain of necessary personal protective equipment (e.g., N95 respirators). The U.S. CDC has recommended use of household cloth by the general public to make cloth face coverings as a method of source contro... |
Implementation science in times of Covid-19 | The emergence of SARS-CoV-2/Covid-19 affects all of us and is associated with rapid and massive changes in healthcare and societies. As a response, a range of interventions for patients and populations have been implemented in health and preventive settings, or need to be implemented in the short and long term. Impleme... |
A nine-month-old girl with respiratory failure and rhomboencephalitis | |
COVID‐19 Pandemic and Its Impact on the Global Economy: What Does It Take to Turn Crisis into Opportunity? | The COVID‐19 pandemic broke out at a time when there were heightened uncertainties in the global economy. Understanding these uncertainties provides an important background for analyzing the impact of the pandemic on the global economy, assessing the effectiveness of those policy measures in combating the pandemic and ... |
The Significant but Understudied Impact of Pathogen Transmission from Humans to Animals | Zooanthroponotic pathogens, which are transmitted from humans to nonhuman animals, are an understudied aspect of global health, despite their potential to cause significant disease burden in wild and domestic animal populations and affect global economies. Some key human‐borne pathogens that have been shown to infect a... |
Importance of diagnostics in epidemic and pandemic preparedness | Diagnostics are fundamental for successful outbreak containment. In this supplement, ‘Diagnostic preparedness for WHO Blueprint pathogens’, we describe specific diagnostic challenges presented by selected priority pathogens most likely to cause future epidemics. Some challenges to diagnostic preparedness are common to ... |
Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus | Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different animals and are frequent targets for binding and modification by pathogens, including influenza viruses. Influenza virus hemagglutinins bind Sias during the infection of their normal hosts, while the encoded neuraminidases an... |
After Covid-19: economic security in EU-Asia connectivity | |
Review of Viral Testing (Polymerase Chain Reaction) and Antibody/Serology Testing for Severe Acute Respiratory Syndrome-Coronavirus-2 for the Intensivist | OBJECTIVE: As the severe acute respiratory syndrome-coronavirus-2 pandemic develops, assays to detect the virus and infection caused by it are needed for diagnosis and management. To describe to clinicians how each assay is performed, what each assay detects, and the benefits and limitations of each assay. DATA SOURCES... |
Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract | The prebiotics and probiotics market is constantly growing due to the positive effects of its consumption on human health, which extends beyond the digestive system. In addition, the synbiotic products market is also expanding due to the synergistic effects between pre- and probiotics that provide additional benefits t... |
Big tech and societal sustainability: an ethical framework | Sustainability is typically viewed as consisting of three forces, economic, social, and ecological, in tension with one another. In this paper, we address the dangers posed to societal sustainability. The concern being addressed is the very survival of societies where the rights of individuals, personal and collective ... |
Genomic characterization of two novel polyomaviruses in Brazilian insectivorous bats | Two novel genomes comprising ≈4.9 kb were identified by next-generation sequencing from pooled organs of Tadarida brasiliensis bats. The overall nucleotide sequence identities between the viral genomes characterized here were less than 80 % in comparison to other polyomaviruses (PyVs), members of the family Polyomaviri... |
Gene Expression Detection Assay for Cancer Clinical Use | Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treatm... |
Context, context, context: how has covid-19 changed implementation globally and how can we ‘lock in’ learning? | |
Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses | The new coronavirus (2019-nCoV) outbreak from December 2019 in Wuhan, Hubei, China, has been declared a global public health emergency. Angiotensin I converting enzyme 2 (ACE2), is the host receptor by 2019-nCov to infect human cells. Although ACE2 is reported to be expressed in lung, liver, stomach, ileum, kidney and ... |
Modeling the role of respiratory droplets in Covid-19 type pandemics | In this paper, we develop a first principles model that connects respiratory droplet physics with the evolution of a pandemic such as the ongoing Covid-19. The model has two parts. First, we model the growth rate of the infected population based on a reaction mechanism. The advantage of modeling the pandemic using the ... |
Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines | Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor coat proteins gp3, gp6, gp7 and gp9. Inovirus display studies have shown that the architecture of in... |
Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases | Recent advances in the development and discovery of pharmacological interventions within the ubiquitin–proteasome system (UPS) have uncovered an enormous potential for possible novel treatments of neurodegenerative disease, cancer, immunological disorder and microbial infection. Interference with proteasome activity, a... |
Diagnostic and prognostic values of cutaneous manifestations in COVID‐19 | |
A Rapid Decrease in Stroke, Acute Coronary Syndrome, and Corresponding Interventions at 65 United States Hospitals Following Emergence of COVID-19 | Background Following the emergence of coronavirus disease 2019 (COVID-19), early reports suggested a decrease in stroke and acute coronary syndrome (ACS). We sought to provide descriptive statistics for stroke and ACS from a sample of hospitals throughout the United States, comparing data from March 2020 to similar mon... |
Pattern dynamics of an epidemic model with nonlinear incidence rate | All species live in space, and the research of spatial diseases can be used to control infectious diseases. As a result, it is more realistic to study the spatial pattern of epidemic models with space and time. In this paper, spatial dynamics of an epidemic model with nonlinear incidence rate is investigated. We find t... |
Influenza Virus Samples, International Law, and Global Health Diplomacy | Indonesia’s decision to withhold samples of avian influenza virus A (H5N1) from the World Health Organization for much of 2007 caused a crisis in global health. The World Health Assembly produced a resolution to try to address the crisis at its May 2007 meeting. I examine how the parties to this controversy used intern... |
A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides | Abstract A series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved inactive against HIV, during the course of the synthesis, a new and highly facile method to realize N-phenylacetamides was developed. Notably, the new route... |
Comparative analysis of gene expression in virulent and attenuated strains of infectious bronchitis virus at sub-codon resolution | Infectious bronchitis virus (IBV) is a member of the genus Gammacoronavirus and the causative agent of avian infectious bronchitis. IBV has a single-stranded, positive-sense RNA genome ~27 kb in length and, like all coronaviruses, produces a set of sub-genomic messenger RNAs (sgmRNAs) synthesised via the viral polymera... |
Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing | BACKGROUND: In the past two decades, bats have emerged as an important model system to study host-pathogen interactions. More recently, it has been shown that bats may also serve as a new and excellent model to study aging, inflammation, and cancer, among other important biological processes. The cave nectar bat or les... |
Hydroxychloroquine-associated Hypoglycemia in Hemodialysis Patients with COVID-19 | |
Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery | BACKGROUND: The long-term pulmonary function and related physiological characteristics of COVID-19 survivors have not been studied in depth, thus many aspects are not understood. METHODS: COVID-19 survivors were recruited for high resolution computed tomography (HRCT) of the thorax, lung function and serum levels of SA... |
Treatment algorithm for COVID-19: a multidisciplinary point of view | The novel coronavirus (Sars-CoV-2) pandemic has spread rapidly, from December to the end of March, to 185 countries, and there have been over 3,000,000 cases identified and over 200,000 deaths. For a proportion of hospitalized patients, death can occur within a few days, mainly for adult respiratory distress syndrome o... |
Could COVID‐19 Infect the Consumer Price Index?(1) | The spread of COVID‐19 has led to sweeping changes in the way households work, spend their time and shop resulting in different shopping patterns and rapid price changes in some goods. How will changes such as these be reflected in headline inflation measures such as the Consumer Prices Index (CPI)? This paper discusse... |
Urine‐based viral diagnostics: an innovation in waiting | |
The Conformational Flexibility of an Internal Fusion Peptide from Sars-Cov Spike Glycoprotein is Modulated by Lipid Membrane Composition | |
The COVID-19 Pandemic and its Impact on the Cardio-Oncology Population | PURPOSE OF REVIEW: The novel Coronavirus (2019-nCoV, COVID-19) is historically one of the most severe acute respiratory syndromes and pandemics to affect the globe in the twenty-first century. Originating in Wuhan, the virus rapidly spread and impacted subsets of populations with initial unclear risk factors contributi... |
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