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Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide‐conjugated morpholino oligomers | Delivery of phosphorodiamidate morpholino oligomers (PMO) into fish cells in vitro and tissues in vivo was examined. Uptake was evaluated by fluorescence microscopy and flow cytometry after treating cultured cells or live rainbow trout with 3′ fluorescein‐tagged PMO. Arginine‐rich peptide conjugated to the 5′ end of th... |
Impact of human coronavirus infections in otherwise healthy children who attended an emergency department | This prospective clinical and virological study of 2,060 otherwise healthy children aged <15 years of age (1,112 males; mean age ± SD, 3.46 ± 3.30 years) who attended the Emergency Department of Milan University's Institute of Pediatrics because of an acute disease excluding trauma during the winter season 2003–2004 wa... |
Ignac Semmelweis—Father of Hand Hygiene | Hungarian obstetrician Ignac Semmelweis (1818–1865) was one of the earliest clinical investigators of modern medical science. In nineteenth century Europe, puerperal fever (childbed fever) was a major clinical and public health problem with very high maternal mortality. It was thought to be caused by miasma, epidemicit... |
Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis | The Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe acute respiratory tract infection with a high fatality rate in humans. Coronaviruses are capable of infecting multiple species and can evolve rapidly through recombination events. Here, we report the complete genomic sequence analysis of a MERS... |
Legitimacy building and e-commerce platform development in China: The experience of Alibaba | Abstract Although existing studies have connected the emergence and development of e-commerce with infrastructure, culture, and regulations, we approach technological and platform acceptance from the perspective of legitimacy building. In our study, legitimacy is categorized into market, relational, and social legitima... |
COVID-19 Pandemic: Impact on Psychiatric Care in the United States, a Review | Abstract The World Health Organization declared the coronavirus outbreak a pandemic on March 11, 2020. Infection by the SARS-CoV2 virus leads to the COVID-19 disease which can be fatal, especially in older patients with medical co-morbidities. The impact to the US healthcare system has been disruptive, and the way heal... |
SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping | The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by COVID-19 infection. Epidemiological studies show that old age and pre-existing disease conditions (hypertension and diabetes) result in severe disease outcome and mo... |
Neurovirulence in mice of soluble receptor-resistant (srr) mutants of mouse hepatitis virus: intensive apoptosis caused by less virulent srr mutant | Three soluble receptor-resistant (srr) mutants, srr7, srr11 and srr18, derived from a highly neurotropic mouse hepatitis virus (MHV) JHMV have a single amino acid mutation in the spike (S) protein. We examined using ICR mice whether the amino acids mutated in the mutants were involved in the neurovirulence. Srr7 showed... |
ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments | Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is the use of small molecules that targe... |
The effect of spent bleaching earth ageing process on its physicochemical and microbial composition and its potential use as a source of fatty acids and triterpenes | This study was aimed at investigating the physicochemical and microbiological changes that took place during the ageing process of spent bleaching earth in the presence of autochthonous microorganisms. Research material included fresh spent bleaching earth (SBE(0)) and the same material after 3 years of storage at the ... |
A Smart Card-Based Electronic School Absenteeism System for Influenza-Like Illness Surveillance in Hong Kong: Design, Implementation, and Feasibility Assessment | BACKGROUND: School-aged children have the highest incidence of respiratory virus infections each year, and transmission of respiratory viruses such as influenza virus can be a major concern in school settings. School absenteeism data have been employed as a component of influenza surveillance systems in some locations.... |
COVID-19 and off label use of drugs: an ethical viewpoint | BACKGROUND: The COVID-19 outbreak is rapidly spread over the world and kills infected patients. There is no proven medication for its treatment, so, all of the medications used for treatment are considered to be off-label. Off-label uses are not under regulation in the outbreak because there is no specific regulation f... |
Improving communication about COVID‐19 and emerging infectious diseases | John Ioannidis writes about the harm caused by misinformation about COVID-19.1 We draw from communication research to offer best practices for reducing misinformation, disseminating accurate health information, and promoting prevention and control recommendations. We recommend three strategies that medical, public heal... |
Topical preparations to reduce SARS‐CoV‐2 aerosolization in head and neck mucosal surgery | AIM: The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has put health care workers at risk when exposed to aerosolized viral particles during upper airway mucosal surgery. The objective of this review was to discuss topical preparations that could be utilized preoperativel... |
Recent developments and contributions from Chinese scientists in multidimensional separations for proteomics and traditional Chinese medicines | The most basic task in proteomics remains the detection and identification of proteins from a biological sample, and the most traditional way to achieve this goal consists in protein separations performed by two‐dimensional polyacrylamide gel electrophoresis (2‐D PAGE). Yet the 2‐D PAGE‐mass spectrometry (MS) approach ... |
Law, and Public Health Policy | Two of the most important tools that assist states in protecting their populations against threats to health are public health policy and public health law. Policy can exist without recourse to law, but where policy has been designed for a long-term purpose, and where voluntary compliance has not proved successful, pol... |
High Content Image Based Analysis Identifies Cell Cycle Inhibitors as Regulators of Ebola Virus Infection | Viruses modulate a number of host biological responses including the cell cycle to favor their replication. In this study, we developed a high-content imaging (HCI) assay to measure DNA content and identify different phases of the cell cycle. We then investigated the potential effects of cell cycle arrest on Ebola viru... |
Analyzing Vaccine Trials in Epidemics With Mild and Asymptomatic Infection | Vaccine efficacy against susceptibility to infection (VE(S)), regardless of symptoms, is an important endpoint of vaccine trials for pathogens with a high proportion of asymptomatic infection, because such infections may contribute to onward transmission and long-term sequelae, such as congenital Zika syndrome. However... |
Tourism companies' risk exposures on text disclosure | Tourism is a risk-prone industry. But most studies focus on tourist risk perception while ignoring company risk exposure. As service providers, the companies play an important role in tourism activities, and systematically identifying the risks they face is vital to the development of the tourism industry. This paper a... |
A Definition Framework for Building Adaptation Projects | Building adaptation encompasses a range of construction activities that improve existing building conditions and extend the effective lives of buildings. The scopes of building adaptation projects vary, and may include rehabilitating failing structures, improving environmental performances, and changing functional uses... |
HHS/CDC Legal Response to SARS Outbreak | Before the severe acute respiratory syndrome (SARS) outbreak, the Centers for Disease Control and Prevention’s (CDC) legal authority to apprehend, detain, or conditionally release persons was limited to seven listed diseases, not including SARS, and could only be changed using a two-step process: 1) executive order of ... |
The rise and fall of infectious diseases: Australian perspectives, 1914‐2014 | Australia has been fortunate in its experience with infectious diseases over the past century. By the 1960s, many communicable diseases were controlled through a combination of high living standards, progressive adoption of vaccines and antimicrobial treatment. Australian medical scientists have made substantial contri... |
Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 | Severe coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2... |
Strengthening National Disease Surveillance and Response—Haiti, 2010–2015 | Haiti’s health system has faced many challenges over the years, with competing health priorities in the context of chronic financial and human resource limitations. As a result, the existing notifiable disease surveillance system was unable to provide the most basic epidemiologic data for public health decision-making ... |
LUNG ULTRASOUND IN THE COVID-19 PANDEMIC: A PRACTICAL GUIDE FOR OBSTETRICIANS AND GYNECOLOGISTS | ABSTRACT The current COVID-19 pandemic is a challenge to every health system over the globe. Unfortunately, it is likely that this emergency will not disappear soon. No health system, with its present resources and work flow is ready to deal with a full-blown wave of this pandemic. Rapid acquisition of specific new ski... |
Reducing the Fatality Rate of COVID-19 by Applying Clinical Insights From Immuno-Oncology and Lung Transplantation | There is an urgent need to identify effective strategies that can stop or reverse the inflammatory process that causes acute lung injury, ARDS, and multi-organ failure in COVID-19. Adaptive clinical trials with parallel enrollment to different arms each evaluating a rationally designed combination modality could provid... |
Fluorinated Derivatives of Benz[4,5]imidazo[1,2-b][1,3] thiazole—Inhibitors of Reproduction of Measles Virus | |
IDBD: Infectious Disease Biomarker Database | Biomarkers enable early diagnosis, guide molecularly targeted therapy and monitor the activity and therapeutic responses across a variety of diseases. Despite intensified interest and research, however, the overall rate of development of novel biomarkers has been falling. Moreover, no solution is yet available that eff... |
Molecular Diagnosis of COVID-19: Challenges and Research Needs | [Image: see text] Molecular diagnosis of COVID-19 primarily relies on the detection of RNA of the SARS-CoV-2 virus, the causative infectious agent of the pandemic. Reverse transcription polymerase chain reaction (RT-PCR) enables sensitive detection of specific sequences of genes that encode the RNA dependent RNA polyme... |
6th International Conference on Emerging Zoonoses | The 6th International Conference on Emerging Zoonoses, held at Cancun, Mexico, 24–27 February 2011, offered 84 participants from 18 countries, a snapshot of current research in numerous zoonoses caused by viruses, bacteria or prions. Co‐chaired by Professors Heinz Feldmann and Jürgen Richt, the conference explored 10 t... |
The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex | The location of autocrine interactions between the v-sis protein and PDGF receptors remains uncertain and controversial. To examine whether receptor-ligand interactions can occur intracellularly, we have constructed fusion proteins that anchor v-sis to specific intracellular membranes. Fusion of a cis-Golgi retention s... |
Declining Public Health Protections within Autocratic Regimes: Impact on Global Public Health Security, Infectious Disease Outbreaks, Epidemics, and Pandemics | Public health emergencies of international concern, in the form of infectious disease outbreaks, epidemics, and pandemics, represent an increasing risk to the worldʼs population. Management requires coordinated responses, across many disciplines and nations, and the capacity to muster proper national and global public ... |
The usefulness of pre-employment and pre-deployment psychological screening for disaster relief workers: a systematic review | BACKGROUND: Individuals who conduct disaster relief work overseas are exposed to a variety of traumatic events that can cause distress and trigger psychological illnesses. Identification of which disaster relief workers may be at risk of experiencing psychological distress or mental health disorders is frequently carri... |
Focal status epilepticus as unique clinical feature of COVID-19: a case report | Abstract SARS-CoV-2, a novel zoonotic coronavirus, is currently spreading all over the world, causing a pandemic disease defined coronavirus disease 2019 (COVID-19). The spectrum of COVID-19 ranges from asymptomatic or mild infection to rapidly progressive, acute respiratory distress syndrome and death 1 .To the best o... |
Hiding in Plain Sight: Conceptualizing the Creeping Crisis | The COVID‐19 crisis is a stark reminder that modern society is vulnerable to a special species of trouble: the creeping crisis. The creeping crisis poses a deep challenge to both academics and practitioners. In the crisis literature, it remains ill‐defined and understudied. It is even harder to manage. As a threat, it ... |
The clinical significance of filmarray pneumonia panel plus in diagnosing pneumonia due to MDRO | |
Haemoglobin Oxygen Affinity in Patients with Severe COVID‐19 Infection | During critical care, at least until the late stage of the disease, severely ill COVID‐19 patients may have relatively well preserved lung compliance but remain severely hypoxaemic. A recent theoretical study suggested a direct interaction between COVID‐19 viral proteins and haemoglobin (Hb) that could lead to a loss o... |
Tocilizumab for the treatment of severe coronavirus disease 2019 | Tocilizumab, an interleukin‐6 inhibitor, may ameliorate the inflammatory manifestations associated with severe coronavirus disease 2019 (COVID‐19) and thus improve clinical outcomes. This was a retrospective review of patients with laboratory‐confirmed severe COVID‐19 who received tocilizumab and completed 14 days of f... |
“This is our next problem”: cleaning up from the covid-19 response | Abstract The purpose of this discussion is to highlight the essential role that solid waste management must play in a humanitarian response towards disasters, in particular the ongoing Covid-19 pandemic. We highlight a number of potential avenues for scholarly investigation into the waste impacts of our response to Cov... |
Lectins: production and practical applications | Lectins are proteins found in a diversity of organisms. They possess the ability to agglutinate erythrocytes with known carbohydrate specificity since they have at least one non-catalytic domain that binds reversibly to specific monosaccharides or oligosaccharides. This articles aims to review the production and practi... |
An update on enterovirus 71 infection and interferon type I response | Enteroviruses are members of Pichornaviridae family consisting of human enterovirus group A, B, C, and D as well as nonhuman enteroviruses. Hand, foot, and mouth disease (HFMD) is a serious disease which is usually seen in the Asia‐Pacific region in children. Enterovirus 71 and coxsackievirus A16 are two important viru... |
Corrigendum to “Spinal anaesthesia for patients with coronavirus disease 2019 and possible transmission rates in anaesthetists: retrospective, single centre, observational cohort study” (Br J Anaesth 2020;124: 670-5) | |
Computational Resources in Infectious Disease: Limitations and Challenges | |
Detection of asymptomatic SARS-CoV-2 exposed individuals by a sensitive S-based ELISA. | To assess the current coronavirus pandemic, there is a pressing need to determine the exposure and seroconversion to SARS-CoV-2 on a local and global level. Here, we demonstrate a sensitive and specific S-protein based assay that is well suited for detection of weak SARS- CoV-2-directed IgG responses, and that could id... |
Complete Genome Sequence of a Nephropathogenic Infectious Bronchitis Virus Strain Isolated in China | Infectious bronchitis virus (IBV) causes tremendous economic losses to the poultry industry. Here, we report the complete genome analysis results for a new natural recombination nephropathogenic IBV strain named SAIBK, which was isolated in the Sichuan province of China in 2005. |
Are Statins Safe in Patients With COVID-19? | |
TRAQUEOTOMÍA EN PACIENTES COVID-19: UN PROCEDIMIENTO NECESARIO DE ALTO RIESGO. EXPERIENCIA DE DOS CENTROS | |
Reply to the Letter to the Editor: Comment on “COVID-19 infection control protocol inside computed tomography suites” | |
Characteristics of human parainfluenza virus type 4 infection in hospitalized children in Korea | BACKGROUND: The characteristics of human parainfluenza virus type 4 (hPIV4) infection are not thoroughly understood. We therefore clarified the characteristics of hPIV4 in Korea. METHOD: From January 2013 to December 2017, children admitted with respiratory tract infection at the Department of Pediatrics in Chung‐Ang U... |
A new twenty-first century science for effective epidemic response | With rapidly changing ecology, urbanization, climate change, increased travel and fragile public health systems, epidemics will become more frequent, more complex and harder to prevent and contain. Here we argue that our concept of epidemics must evolve from crisis response during discrete outbreaks to an integrated cy... |
Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types | BACKGROUND: Each cell type found within the human body performs a diverse and unique set of functions, the disruption of which can lead to disease. However, there currently exists no systematic mapping between cell types and the diseases they can cause. METHODS: In this study, we integrate protein–protein interaction d... |
COVID-19 outbreaks in U.S. immigrant detention centers: the urgent need to adopt CDC guidelines for prevention and evaluation | There have been several significant outbreaks of COVID-19 in federal immigrant detention centers, which lack clear and consistent guidelines across Department of Homeland Security (DHS) agencies to limit the spread of COVID-19. The Centers for Disease Control and Prevention (CDC) has issued detailed guidelines for the ... |
Novel Coronavirus Disease (COVID-19) | The present outbreak of the novel coronavirus initially called as “2019 novel coronavirus” or “2019-nCoV” by the World Health Organization (WHO), is also known as “Wuhan coronavirus” or “Wuhan pneumonia”, as it started in the Wuhan city of China in early December of 2019. This new coronavirus-associated acute respirato... |
Unmasking psychological reasons of delay in acute coronary syndromes presentation during the COVID‐19 pandemic | |
Genetic restriction of murine hepatitis virus type 3 expression in liver and brain: comparative study in BALB/c and C3H mice by immunochemistry and hybridization in situ | To study the host-dependent genetic variations in murine hepatitis virus type 3 (MHV 3) induced diseases, we localized the sites of MHV 3 (Mill Hill strain) expression within liver and brain by immunohistochemistry or hybridization in situ. Two strains of mice were studied: BALB/c mice, which develop an acute and letha... |
Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines | There are two types of feline coronaviruses that can be distinguished by serology and sequence analysis. Type I viruses, which are prevalent in the field but are difficult to isolate and propagate in cell culture, and type II viruses, which are less prevalent but replicate well in cell culture. An important determinant... |
The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages | Antibody-dependent enhancement (ADE) of feline infectious peritonitis virus (FIPV) infection was studied in feline alveolar macrophages and human monocyte cell line U937 using mouse neutralizing monoclonal antibodies (MAbs) directed to the spike protein of FIPV. Even among the MAbs that have been shown to recognize the... |
Exaggerated information and COVID‐19 outbreak | We read the article on "Coronavirus disease 2019: the harms of exaggerated information and non-evidence-based measures" with a great interest [1]. Ioannidis noted that "It is important to differentiate promptly the true epidemic from an epidemic of false claims and potentially harmful actions [1]." |
Clinical Impact of Infection with Pandemic Influenza (H1N1) 2009 Virus in Naïve Nucleus and Multiplier Pig Herds in Norway | The Norwegian pig population has been free from influenza viruses until 2009. The pandemic influenza outbreak during the autumn 2009 provided an opportunity to study the clinical impact of this infection in an entirely naïve pig population. This paper describes the results of a case-control study on the clinical impact... |
ICU beds: less is more? Yes | |
A binning tool to reconstruct viral haplotypes from assembled contigs | Infections by RNA viruses such as Influenza, HIV still pose a serious threat to human health despite extensive research on viral diseases. One challenge for producing effective prevention and treatment strategies is high intra-species genetic diversity. As different strains may have different biological properties, cha... |
Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients | BACKGROUND: Chlorine is a known pulmonary irritant gas that may cause acute damage in the respiratory system. In this paper, the socio-demographic and clinical characteristics of 39 accidentally exposed patients to chlorine gas are reported and different emergency treatment modalities are also discussed. METHODS: Two e... |
Potential role for tissue factor in the pathogenesis of hypercoagulability associated with in COVID-19 | In December 2019, a new and highly contagious infectious disease emerged in Wuhan, China. The etiologic agent was identified as a novel coronavirus, now known as Severe Acute Syndrome Coronavirus-2 (SARS-CoV-2). Recent research has revealed that virus entry takes place upon the union of the virus S surface protein with... |
Selected veterinary concerns of geriatric rats, mice, hamsters and gerbils | Improved husbandry and better knowledge of exotic pets have led to a gradual increase in the lifespan of pets such as rats, mice, hamsters, and gerbils. Much of the information we have on these senior patients is derived from the laboratory animal studies and anecdotal practitioner information. While the small size of ... |
Coordinated Response to SARS, Vancouver, Canada | Two Canadian urban areas received travelers with severe acute respiratory syndrome (SARS) before the World Health Organization issued its alert. By July 2003, Vancouver had identified 5 cases (4 imported); Toronto reported 247 cases (3 imported) and 43 deaths. Baseline preparedness for pandemic threats may account for ... |
The Early Effects of Social Distancing Resultant From COVID-19 on Admissions To a Level I Trauma Center | |
Burden of exposure to infectious bursal disease virus, infectious bronchitis virus, Newcastle disease virus, Mycoplasma gallisepticum, and intestinal parasites in introduced broiler chickens on the Galapagos | Diseases in introduced broilers can possibly spill over to wild birds on the Galapagos. Knowledge about the current burden of exposure to pathogens in broilers on the Galapagos is very limited. The objective of the study reported here was to measure the burden of exposure to infectious bursal disease virus (IBDV), infe... |
The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek | With 40% of the world population at risk, infections with dengue virus (DENV) constitute a serious threat to public health. While there is no antiviral therapy available against this potentially lethal disease, the efficacy of the only approved vaccine is not optimal and its safety has been recently questioned. In orde... |
COVID-19 poses novel challenges for global primary care | COVID-19 is presenting novel challenges for global primary care, and its response has been inspiring, varied, and also troubling. |
Packaging of porcine reproductive and respiratory syndrome virus replicon RNA by a stable cell line expressing its nucleocapsid protein | Porcine reproductive and respiratory syndrome virus (PRRSV), a member of the Arteriviridae family, is one of the most common and economically important swine pathogens. Although both live-attenuated and killed-inactivated vaccines against the virus have been available for a decade, PRRSV is still a major problem in the... |
Could the D614 G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality? | Increasing number of deaths due to COVID-19 pandemic has raised serious global concerns. Higher testing capacity and ample intensive care availability could explain lower mortality in some countries compared to others. Nevertheless, it is also plausible that the SARS-CoV-2 mutations giving rise to different phylogeneti... |
Homology Models and Molecular Dynamics Simulations of Main Proteinase from Coronavirus Associated with Severe Acute Respiratory Syndrome (SARS) | In this study, two structural models (denoted as M(pro)ST and M(pro)SH) of the main proteinase (M(pro)) from the novel coronavirus associated with severe acute respiratory syndrome (SARS‐CoV) were constructed based on the crystallographic structures of M(pro) from transmissible gastroenteritis coronavirus (TGEV) (M(pro... |
Bibliometric analysis of Severe Acute Respiratory Syndrome-related research in the beginning stage | Severe Acute Respiratory Syndrome (SARS) has become the major of health issues since its outbreak early 2003. No analyses by bibliometric technique that have examined this topic exist in the literature. The objective of this study is to conduct a bibliometric analysis of all SARS-related publications in Science Citatio... |
Neue und seltene pneumotrope Viren | While acute viral respiratory tract infections are one of the major reasons for the loss of productivity among the general population in industrialized nations, they are one of the top killers among infants worldwide, in particular in low-income countries. With the advances in molecular diagnostics and the introduction... |
One health: the importance of companion animal vector-borne diseases | The international prominence accorded the 'One Health' concept of co-ordinated activity of those involved in human and animal health is a modern incarnation of a long tradition of comparative medicine, with roots in the ancient civilizations and a golden era during the 19(th )century explosion of knowledge in the field... |
Mechanisms that determine plasma cell lifespan and the duration of humoral immunity | Summary: Humoral immunity following vaccination or infection is mainly derived from two types of cells: memory B cells and plasma cells. Memory B cells do not actively secrete antibody but instead maintain their immunoglobulin in the membrane‐bound form that serves as the antigen‐specific B‐cell receptor. In contrast, ... |
COVID‐19 pneumonia in kidney transplant recipients—Where we are? | In late December 2019, China reported cases of respiratory illness in humans that involved a novel coronavirus SARS‐CoV‐2. On March 20, 2020, the first coronavirus disease 2019 (COVID‐19) in Brazil was diagnosed, and by now, we present the report on the first case of COVID among transplant recipients in our country. A ... |
COVID-19 preventive measures showing an unintended decline in infectious diseases in Taiwan | Abstract Many communicable diseases may have contact, airborne, and/or droplets transmission. Following the COVID-19 outbreak, Taiwan government implemented the use of masks and sanitizer and other prevention measures, like social distancing for prevention. This public response may have likely contributed significantly... |
Defining the spectrum of genome policy | Many achievements in the genome sciences have been facilitated by policies that have prioritized genome research, secured funding and raised public and health-professional awareness. Such policies should address ethical, legal and social concerns, and are as important to the scientific and commercial development of the... |
OPV-like poliovirus type 1 detection in patients with severe acute respiratory syndrome | |
Management of asthma during the Coronavirus disease 2019 outbreak | |
Care of Asymptomatic SARS‐CoV‐2 positive Kidney Transplant Recipients | Sharing of experience amongst transplant community through various platforms and rapid publications has proven invaluable during the COVID‐19 pandemic (1‐3). The general consensus seemed to be that most kidney transplant recipients would have a moderate or mild course, although some may progress to a more severe diseas... |
Healthy people 2100: modeling population health impacts of climate change | Quantitatively estimating the potential health impacts of climate change is facilitated by multi-determinant models that integrate micro- to macro-level exposures and processes that influence disease occurrence, including the public health responses, in order to identify regions and population groups that may be more v... |
Re: Toward a consensus view in the management of acute facial injuries during the Covid-19 pandemic | |
Growing networks with communities: A distributive link model | Evolution and popularity are two keys of the Barabasi–Albert model, which generates a power law distribution of network degrees. Evolving network generation models are important as they offer an explanation of both how and why complex networks (and scale-free networks, in particular) are ubiquitous. We adopt the evolut... |
A natural reassortant and mutant serotype 3 reovirus from mink in China | Mammalian orthoreoviruses (MRVs) are widespread and infect virtually all mammals. We report here the first case of a natural mutant and reassortant serotype 3 reovirus from mink in China, known as MRV3 SD-14. Whole-genome sequence analysis showed that the MRV3 SD-14 may have resulted from a reassortment involving MRVs ... |
Human bocavirus types 1, 2 and 3 in acute gastroenteritis of childhood | Aim: Recently identified human bocavirus (HBoV) types 2 and 3 have been associated with acute gastroenteritis in children. We studied 878 stool specimens from children with acute gastroenteritis and 112 controls (43 children with unspecified fever, 33 with respiratory tract infection and 36 healthy children) for known ... |
Zoonotic disease research in East Africa | BACKGROUND: The East African region is endemic with multiple zoonotic diseases and is one of the hotspots for emerging infectious zoonotic diseases with reported multiple outbreaks of epidemic diseases such as Ebola, Marburg and Rift Valley Fever. Here we present a systematic assessment of published research on zoonoti... |
Health-protective behaviour, social media usage and conspiracy belief during the COVID-19 public health emergency | BACKGROUND: Social media platforms have long been recognised as major disseminators of health misinformation. Many previous studies have found a negative association between health-protective behaviours and belief in the specific form of misinformation popularly known as ‘conspiracy theory’. Concerns have arisen regard... |
Orthopaedic resident management during the COVID-19 pandemic – AIIMS model | |
Equine Arteritis Virus Does Not Induce Interferon Production in Equine Endothelial Cells: Identification of Nonstructural Protein 1 as a Main Interferon Antagonist | The objective of this study was to investigate the effect of equine arteritis virus (EAV) on type I interferon (IFN) production. Equine endothelial cells (EECs) were infected with the virulent Bucyrus strain (VBS) of EAV and expression of IFN-β was measured at mRNA and protein levels by quantitative real-time RT-PCR an... |
Chapter 13 Transmission of Infectious Diseases Through Breast Milk and Breastfeeding | |
Viral Diarrhea | Abstract Viral gastroenteritis is among the most common illnesses affecting humans and has greatest impact at the extremes of age. The spectrum of disease can range from asymptomatic infections to severe disease with dehydration. In contrast to bacterial pathogens, enteric viruses cannot multiply outside their host; he... |
IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections | Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IF... |
Update on the neurology of COVID‐19 | Though infection with the SARS-CoV2 virus predominantly manifests in the lung as an interstitial pneumonia ("ground glass opacities"), there is increasing evidence that the virus invades all compartments of the body, particularly the eyes, heart, skin, kidneys, and the central nervous system(CNS).1 This article is prot... |
Severe maternal morbidity due to respiratory disease and impact of 2009 H1N1 influenza A pandemic in Brazil: results from a national multicenter cross-sectional study | BACKGROUND: The aim of this study was to assess the burden of respiratory disease, considering the influenza A pandemic season (H1N1pdm09), within the Brazilian Network for Surveillance of Severe Maternal Morbidity, and factors associated with worse maternal outcome. METHODS: A multicenter cross-sectional study, involv... |
A Host Factor GPNMB Restricts Porcine Circovirus Type 2 (PCV2) Replication and Interacts With PCV2 ORF5 Protein | Porcine circovirus type 2 (PCV2) is the infectious agent of postweaning multisystemic wasting syndrome (PMWS). The recently discovered open reading frame 5 (ORF5) in PCV2 genome encodes a non-structural protein. Previous study revealed that ORF5 protein inhibits cell proliferation and may interact with host transmembra... |
Effect of COVID‐19 pandemic on stroke admission rates in a Norwegian population | OBJECTIVES: There are concerns that public anxiety around COVID‐19 discourages patients from seeking medical help. The aim of this study was to see how lockdown due to the pandemic affected the number of admissions of acute stroke. METHODS: All patients discharged from Akershus University Hospital with a diagnosis of t... |
Rapid and sensitive detection of multiple genes from the SARS‐Coronavirus using quantitative RT‐PCR with dual systems | The outbreak of severe acute respiratory syndrome (SARS) was caused by a newly identified coronavirus (SARS‐CoV) in 2003. To detect early SARS‐CoV infection, a one‐step, real‐time quantitative reverse transcription‐polymerase chain reaction (RT‐PCR) assay was developed that could simultaneously detect nucleocapsid (N),... |
Potential Role of Platelets in COVID‐19: Implications for Thrombosis | For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also m... |
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