title stringlengths 0 221 | text stringlengths 0 375k |
|---|---|
Developing clinical practice guidelines for the integration of Chinese medicine and biomedicine: A new process | Abstract Introduction Despite the integration of Chinese medicine and biomedicine which has emerged in clinical practice worldwide, a comprehensive development process for clinical practice guidelines (CPG) has up to now been missing. A valid method for the rational use of predictions for herb-drug interaction is a big... |
Detection of the Middle East respiratory syndrome coronavirus in dromedary camel’s seminal plasma in Saudi Arabia 2015–2017 | The Middle East respiratory syndrome coronavirus (MERS‐CoV) is an emergent respiratory virus. Dromedary camels are currently the only known reservoir of MERS‐CoV and are capable of transmitting the virus within a herd. The role of semen in the transmission of MERS‐CoV has never been investigated as yet, to the best of ... |
Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State | Epimedium koreanum Nakai has been extensively used in traditional Korean and Chinese medicine to treat a variety of diseases. Despite the plant’s known immune modulatory potential and chemical make-up, scientific information on its antiviral properties and mode of action have not been completely investigated. In this s... |
Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis prevents lipopolysaccharide–induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF–κB pathways | ACE2 and Ang–(1–7) have important roles in preventing acute lung injury. However, it is not clear whether upregulation of the ACE2/Ang–(1–7)/Mas axis prevents LPS–induced injury in pulmonary microvascular endothelial cells (PMVECs) by inhibiting the MAPKs/NF–κB pathways. Primary cultured rat PMVECs were transduced with... |
Evolution of information-driven HIV/AIDS policies in China | Background As China continues to commit to universal access to HIV/AIDS prevention, treatment and care services, its HIV/AIDS policies have become increasingly information driven. We review China’s key national-level HIV/AIDS policies and discuss policy gaps and challenges ahead. Methods We conducted a desk review of k... |
Tracing SARS-Coronavirus Variant with Large Genomic Deletion | |
The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication | Foot-and-mouth disease virus (FMDV) can infect domestic and wild cloven-hoofed animals. The non-structural protein 3D plays an important role in FMDV replication and pathogenesis. However, the interaction partners of 3D, and the effects of those interactions on FMDV replication, remain incompletely elucidated. In the p... |
Human metapneumovirus and human coronavirus infection and pathogenicity in Saudi children hospitalized with acute respiratory illness | BACKGROUND AND OBJECTIVES: Human metapneumovirus (hMPV) and the Netherlands human coronavirus (HCoV-NL63) have been isolated from children with respiratory tract infection. The prevalence of these viruses has not been reported from Saudi Arabia. We sought to determine whether hMPV and HCoV-NL63 are responsible for acut... |
COVID-19 mortality and health-care resources: organization | |
Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses | Of the Orthomyxoviridae family of viruses, only influenza A viruses are thought to exist as multiple subtypes and has non-human maintenance hosts. In April 2011, nasal swabs were collected for virus isolation from pigs exhibiting influenza-like illness. Subsequent electron microscopic, biochemical, and genetic studies ... |
Q&A: What are pathogens, and what have they done to and for us? | Microbes are found on us, within us and around us. They inhabit virtually every environment on the planet and the bacteria carried by an average human, mostly in their gut, outnumber human cells. The vast majority of microbes are harmless to us, and many play essential roles in plant, animal and human health. Others, h... |
Hypothesized and found mechanisms for potentiation of bradykinin actions | Potentiation of hormone actions can occur by different mechanisms, including inhibition of degrading enzymes, interaction with the hormone receptor leading to stabilization of bioactive conformation or leading to receptor homo‐ and hetero‐oligomerization, receptor phosphorylation and dephosphorylation or can occur by d... |
Coronavirus: Stehen wir am Beginn einer neuen Pandemie? | Beunruhigende Nachrichten aus China, erste Erkrankungsfälle in Europa. Das Coronoavirus breitet sich aus. MMW-Schriftleiter Prof. Johannes Bogner, München, berichtet aus infektiologischer Sicht über den derzeitigen Kenntnisstand und macht Sie zugleich fit für Fragen Ihrer Patienten. |
Surveillance of travel-associated diseases at two referral centres in Marseille, France: a 12-year survey | BACKGROUND: With increasing international travel and historically high numbers of residents visiting friends and relatives overseas, travel-associated illnesses are frequent in Marseille, France. We report the changing epidemiology of travel-related illnesses over a 12-year period. METHODS: A single site GeoSentinel su... |
Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome | A subunit vaccine, RBD-S, is under development to prevent severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV), which is classified by the US NIH as a category C pathogen. This vaccine is comprised of a recombinant receptor-binding domain (RBD) of the SARS-CoV spike (S) protein and formulated ... |
COVID‐19 in Lung Transplant Recipients | Solid organ transplant recipients are considered at a high risk for severe COVID‐19 disease due to chronic immunosuppression, though their risk compared to that of the general population remains unclear. Management of lung transplant recipients can be particularly challenging given high levels of maintenance immunosupp... |
Further evidence that far‐UVC for disinfection is unlikely to cause erythema or pre‐mutagenic DNA lesions in skin | It is well understood that ultraviolet‐C (UVC) radiation is effective for the destruction of micro‐organisms and drug‐resistant bacteria and is being investigated for its effectiveness at destroying the virus responsible for the current Covid‐19 global pandemic. Far‐UVC (200 ‐ 220 nm) has been proposed as an effective ... |
Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China | The ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, provisionally termed 2019-nCoV. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection. Although bats are likely reserv... |
Emerging strategies for the noninvasive diagnosis of nosocomial pneumonia | Introduction: Hospital-acquired pneumonia is a common and therapeutically challenging diagnosis that can lead to severe sepsis, critical illness, and respiratory failure. In this review, we focus on efforts to enhance microbiological diagnosis of hospital-acquired pneumonia, including ventilator-associated pneumonia. A... |
On a Statistical Transmission Model in Analysis of the Early Phase of COVID-19 Outbreak | Since December 2019, a disease caused by a novel strain of coronavirus (COVID-19) had infected many people and the cumulative confirmed cases have reached almost 180,000 as of 17, March 2020. The COVID-19 outbreak was believed to have emerged from a seafood market in Wuhan, a metropolis city of more than 11 million pop... |
Akute Exazerbation bei COPD | |
Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response | |
Epidemiologic data and pathogen genome sequences: a powerful synergy for public health | Epidemiologists aim to inform the design of public health interventions with evidence on the evolution, emergence and spread of infectious diseases. Sequencing of pathogen genomes, together with date, location, clinical manifestation and other relevant data about sample origins, can contribute to describing nearly ever... |
Integration of transcriptomic profile of SARS-CoV-2 infected normal human bronchial epi-thelial cells with metabolic and protein-protein interaction networks | A novel coronavirus (SARS-CoV-2, formerly known as nCoV-2019) that causes an acute respiratory disease has emerged in Wuhan, China and spread globally in early 2020. On January the 30th, the World Health Organization (WHO) declared spread of this virus as an epidemic and a public health emergency. With its highly conta... |
Nuclear localization signal in TRIM22 is essential for inhibition of type 2 porcine reproductive and respiratory syndrome virus replication in MARC-145 cells | Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes one of the most economically important swine diseases worldwide. Tripartite motif-containing 22 (TRIM22), a TRIM family protein, has been identified as a crucial restriction factor that inhibits a group of human viruses. Currently, the role of... |
Remdesivir in Treatment of COVID-19: A Systematic Benefit–Risk Assessment | INTRODUCTION: There is a need to identify effective, safe treatments for COVID-19 (coronavirus disease) rapidly, given the current, ongoing pandemic. A systematic benefit–risk assessment was designed and conducted to examine the benefit–risk profile of remdesivir in COVID-19 patients compared with standard of care, pla... |
Amplicon competition enables end-point quantitation of nucleic acids following isothermal amplification | It is inherently difficult to quantitate nucleic acid analytes with most isothermal amplification assays. We have now developed loop-mediated isothermal amplification (LAMP) reactions in which competition between defined numbers of ‘false’ and ‘true’ amplicons leads to order of magnitude quantitation via a single end-p... |
Prospective surveillance study of acute respiratory infections, influenza-like illness and seasonal influenza vaccine in a cohort of juvenile idiopathic arthritis patients | BACKGROUND: Acute respiratory infections (ARI) are frequent in children and complications can occur in patients with chronic diseases. We evaluated the frequency and impact of ARI and influenza-like illness (ILI) episodes on disease activity, and the immunogenicity and safety of influenza vaccine in a cohort of juvenil... |
COVID-19: review on latest available drugs and therapies against SARS-CoV-2. Coagulation and inflammation cross-talking | SARS-CoV-2 is the agent responsible for COVID-19. The infection can be dived into three phases: mild infection, the pulmonary phase and the inflammatory phase. Treatment options for the pulmonary phase include: Hydroxychloroquine, Remdesivir, Lopinavir/Ritonavir. The inflammatory phase includes therapeutic options like... |
How 3D Printing and Social Media Tackles the PPE Shortage during Covid – 19 Pandemic | During the recent Covid-19 pandemic, additive Technology and Social Media were used to tackle the shortage of Personal Protective Equipment. A literature review and a social media listening software were employed to explore the number of the users referring to specific keywords related to 3D printing and PPE. Additiona... |
Cellular unfolded protein response against viruses used in gene therapy | Viruses are excellent vehicles for gene therapy due to their natural ability to infect and deliver the cargo to specific tissues with high efficiency. Although such vectors are usually “gutted” and are replication defective, they are subjected to clearance by the host cells by immune recognition and destruction. Unfold... |
Neumoperitoneo espontáneo no quirúrgico en paciente COVID-19 positivo con neumonía bilateral severa | |
On the different sources of cooperativity in pH titrating sites of a membrane protein channel | ABSTRACT. Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of different experiments, even involving site-directed mutagenesis, to identify the different sources... |
Structural similarity between HIV-1 gp41 and SARS-CoV S2 proteins suggests an analogous membrane fusion mechanism | Abstract SARS-associated coronavirus (SARS-CoV) has been identified as the causal agent of a new emerging disease: severe acute respiratory syndrome (SARS). Its spike protein S2 is responsible for mediating fusion of viral and cellular membrane. In this study, we modeled the 3D structure of S2 subunit and compared this... |
Rhinovirus and Coronavirus Infection-Associated Hospitalizations among Older Adults | Rhinoviruses and coronaviruses are recognized as the major causes of the common cold syndrome. The role of these viruses in more serious respiratory illnesses resulting in hospitalization is less well defined. During a winter when influenza A infection was prevalent, 100 elderly adults hospitalized because of cardiopul... |
Adverse effects of Influenza A(H1N1)pdm09 virus infection on growth performance of Norwegian pigs - a longitudinal study at a boar testing station | BACKGROUND: Influenza A(H1N1)pdm09 virus infection in Norwegian pigs was largely subclinical. This study tested the hypothesis that the infection causes negligible impact on pigs’ growth performance in terms of feed conversion efficiency, daily feed intake, daily growth, age on reaching 100 kg bodyweight and overall fe... |
Association between genetic polymorphisms of MMP8 and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China | BACKGROUND: Steroid-induced osteonecrosis of the femoral head (ONFH) is the most common clinical nontraumatic ONFH. Once ONFH occurs, it seriously reduces patients’ quality of life. The matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP) system was found to play a significant role in the developme... |
Pre‐procedural COVID‐19 Screening: Do Rhinologic Patients Carry a Unique Risk Burden for False Negative Results? | |
Evaluating the diagnostic accuracy of the WHO Severe Acute Respiratory Infection (SARI) criteria in Middle Eastern children under two years over three respiratory seasons | OBJECTIVE: The World Health Organization created the Severe Acute Respiratory Infection (SARI) criteria in 2011 to monitor influenza (flu)-related hospitalization. Many studies have since used the SARI case definition as inclusion criteria for surveillance studies. We sought to determine the sensitivity, specificity, p... |
Cordyceps industry in China | Cordyceps, as a general term, describes a group of ascomycetous fungi growing on arthropods and other related fungi. Some cordyceps have been used in traditional Chinese medicine for centuries and cordyceps-derived products are currently a big industry in China. A number of medicinal and health products have been devel... |
Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation | Circular RNAs (circRNAs) are an integral component of the host competitive endogenous RNA (ceRNA) network. These noncoding RNAs are characterized by their unique splicing reactions to form covalently closed loop structures and play important RNA regulatory roles in cells. Recent studies showed that circRNA expressions ... |
Cutaneous manifestations of COVID‐19: A review of the published literature | COVID‐19 is a highly contagious respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2). COVID‐19 outbreak, which caused thousands of deaths, has been declared a pandemic by the World Health Organization in March 2020. The infection has been reported to demonstrate different t... |
Genetic epilepsies and COVID‐19 pandemic: Lessons from the caregiver perspective | |
Chest computed tomography findings of coronavirus disease 2019 (COVID-19) pneumonia | OBJECTIVE: To retrospectively analyze the chest computed tomography (CT) features in patients with coronavirus disease 2019 (COVID-19) pneumonia. METHODS: From January 9, 2020, to February 26, 2020, totally 56 laboratory-confirmed patients with COVID-19 underwent chest CT. For 40 patients, follow-up CT scans were obtai... |
High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus‐induced exacerbations: A prospective cohort study | BACKGROUND: The major trigger of asthma exacerbations is infection with a respiratory virus, most commonly rhinovirus. Type 2 inflammation is known to be associated with an increased risk of exacerbations in general. Whether type 2 inflammation at baseline increases the risk of future virus‐induced exacerbations is unk... |
Chapter 11 Laboratory Biosafety and Good Laboratory Practices | Abstract In order to ensure biosafety, comprehensive guidelines have been prepared by the National Institutes of Health (NIH) and the World Health Organization (WHO). Both the NIH and the WHO guidelines recommend classification of biological agents based on their potential to cause harm to humans, animals, and the envi... |
Spinoza: thoughts on hope in our political present | |
Death rate mystery | Knowing the true rate of death from covid-19 will help us fight the pandemic, but for the moment it eludes us, reports Michael Le Page |
Therapeutic ISCOMATRIX™ adjuvant vaccine elicits effective anti-tumor immunity in the TRAMP-C1 mouse model of prostate cancer | Cancer vaccine development has proven challenging with the exception of some virally induced cancers for which prophylactic vaccines exist. Currently, there is only one FDA approved vaccine for the treatment of prostate cancer and as such prostate cancer continues to present a significant unmet medical need. In this st... |
The importance of PHC-based measures in controlling COVID-19 outbreak: implications for global health system | |
Hydroxychloroquine-induced Stevens–Johnson syndrome in COVID-19: a rare case report | The international outbreak of respiratory illness termed coronavirus disease 2019 (COVID-19) began in December 2019 that has affected >0.8 million individuals. Self-limiting respiratory tract involvement, severe pneumonia, multiorgan failure and death are the spectrum of COVID-19. To date, there are no especial therape... |
Waste Not, Want Not: Re-Usability of N95 Masks | As the spread of COVID-19 illnesses continues to escalate amidst a substandard supply of protective equipment for health care providers, the question of extended use or reuse of N95 masks has emerged. As well, the relative effectiveness of the N95 compared to other mask types have been entertained. A recent article by ... |
Silent War to Emerging or Re-emerging Respiratory Infection Diseases Badly Kept in Mind | |
Comparative analysis of cytokine transcript profiles within mediastinal lymph node compartments of pigs after infection with porcine reproductive and respiratory syndrome genotype 1 strains differing in pathogenicity | Porcine reproductive and respiratory syndrome virus (PRRSV) induces a weak immune response enabling it to persist in different organs of infected pigs. This has been attributed to the ability of PRRSV to influence the induction of cytokine responses. In this study, we investigated the cytokine transcriptional profiles ... |
Memory T-cell competition for bone marrow seeding | The presence in the bone marrow of memory CD8 T cells is well recognized. However, it is still largely unclear how T-cell migration from the lymphoid periphery to the bone marrow is regulated. In the present report, we show that antigen-specific CD4 T cells, as well as antigen-specific CD8 T cells, localize to the bone... |
Potential challenges of employing a formal environmental scanning approach in hospitality organizations | Most previous studies on environmental scanning (ES) in the field of hospitality management suggest that hospitality organizations establish formal systematic ES procedures and have a freestanding ES unit to identify opportunities and threats in their external environment. However, some serious criticisms have been rai... |
Biomimetic nanoparticles as universal influenza vaccine | Abstract Pandemic virus infections, such as seasonal influenza, severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, pose a major public health threat globally. 1 , 2 Much effort has been devoted to suppress the virus, including vaccine prevention, autoimmunity enhancement, an... |
Secondary Syphilis with Pleural Effusion: Case Report and Literature Review | Here we present a case of a 38-year-old Indian man with a history of extramarital relationships who presented with pleurisy, skin rash, and radiological findings of pleural effusion. After thorough investigation of the etiology of his acute illness, he was found to be positive for syphilis. Review of literature reveale... |
Rapid community-driven development of a SARS-CoV-2 tissue simulator | The 2019 novel coronavirus, SARS-CoV-2, is an emerging pathogen of critical significance to international public health. Knowledge of the interplay between molecular-scale virus-receptor interactions, single-cell viral replication, intracellular-scale viral transport, and emergent tissue-scale viral propagation is limi... |
Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the Coronavirus Disease 2019 Pandemic | IMPORTANCE: People exposed to coronavirus disease 2019 (COVID-19) and a series of imperative containment measures could be psychologically stressed, yet the burden of and factors associated with mental health symptoms remain unclear. OBJECTIVE: To investigate the prevalence of and risk factors associated with mental he... |
Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread | Skin infection with the poxvirus vaccinia (VV) elicits a powerful, inflammatory cellular response that clears virus infection in a coordinated, spatially organized manner. Given the high concentration of pro-inflammatory effectors at areas of viral infection, it is unclear how tissue pathology is limited while virus-in... |
Multimonth Dispensing of Antiretroviral Therapy Protects the Most Vulnerable From 2 Pandemics at Once | We encourage governments in countries that have a high prevalence of people living with HIV to implement multimonth dispensing of antiretroviral therapy to safeguard both patients with HIV and health care workers from coronavirus disease 2019. |
Engineering targeted viral vectors for gene therapy | To achieve therapeutic success, transfer vehicles for gene therapy must be capable of transducing target cells while avoiding impact on non-target cells. Despite the high transduction efficiency of viral vectors, their tropism frequently does not match the therapeutic need. In the past, this lack of appropriate targeti... |
Viruses are frequently present as the infecting agent in acute exacerbations of chronic obstructive pulmonary disease in patients presenting to hospital | BACKGROUND: Viral causes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are well recognised but only recently have rapid tests become available. AIMS: To identify respiratory viruses in the general population and those associated with hospitalisation in AECOPD using polymerase chain reaction (... |
Respiratory disease in pregnancy | Abstract A variety of respiratory complications can be encountered in pregnancy. An understanding of the pathophysiology of pregnancy is important in the management of such complications. Despite the changes in immunity, the incidence of respiratory infections is not higher in pregnancy. Asthma is the most common preex... |
Transient virus infection and multiple sclerosis | Multiple sclerosis (MS) is a chronic, demyelinating disease of the CNS in which autoimmunity to myelin plays a role in pathogenesis. The epidemiology of MS indicates that it may be triggered by a virus infection before the age of adolescence, but attempts to associate a specific virus with MS have produced equivocal re... |
The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and coronaviruses are evolutionarily related. | Sequence analysis of the 3' part (8 kb) of the polymerase gene of the torovirus prototype Berne virus (BEV) revealed that this area contains at least two open reading frames (provisionally designated ORF1a and ORF1b) which overlap by 12 nucleotides. The complete sequence of ORF1b (6873 nucleotides) was determined. Like... |
Infection as an Environmental Trigger of Multiple Sclerosis Disease Exacerbation | Over the past several decades, significant advances have been made in identifying factors that contribute to the pathogenesis of multiple sclerosis (MS) and have culminated in the approval of some effective therapeutic strategies for disease intervention. However, the mechanisms by which environmental factors, such as ... |
Chapter 5 Laboratory Diagnosis of Viral Infections | Publisher Summary Specific diagnoses of a viral infection are described in this chapter that are generally of five types: those that demonstrate the presence of infectious virus; those that detect viral antigens; those that detect viral nucleic acids; those that demonstrate the presence of an agent-specific antibody re... |
Sports balls as potential SARS-CoV-2 transmission vectors | Abstract Objects passed from one player to another have not been assessed for their ability to transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that the surface of sport balls, notably a football, tennis ball, golf ball, and cricket ball could not harbour inactivated virus when it was swa... |
A leguminous trypsin-chymotrypsin inhibitor Limenin with antifungal activity from Phaseolus limensis | A trypsin-chymotrypsin inhibitor, designated Limenin, with both antifungal and antibacterial activity, and exhibiting a molecular mass of 18.0 kDa in SDS–polyacrylamide gel electrophoresis, was isolated from the large lima bean (Phaseolus limensis) legumes by a combination of extraction, ammonium sulfate precipitation,... |
Artificial Intelligence and COVID-19: A Multidisciplinary Approach | The COVID-19 pandemic is taking a colossal toll in human suffering and lives. A significant amount of new scientific research and data sharing is underway due to the pandemic which is still rapidly spreading. There is now a growing amount of coronavirus related datasets as well as published papers that must be leverage... |
Air ventilation assessment under unstable atmospheric stratification — A comparative study for Hong Kong | Abstract In most current air ventilation assessment (AVA) studies, a simple neutral assumption that does not consider thermal effects is adopted, particularly for numerical simulation practices. With statistics of daytime observations during summer in Hong Kong as an example, this study demonstrates that neutral atmosp... |
Responding to Hospital System and Student Curricular Needs: COVID‐19 Student Service Corps | Throughout March 2020, cases of COVID‐19 grew exponentially, and New York emerged as an epicenter of the crisis. Social distancing, shortages of personal protective equipment, and clinical care needs necessitated that students be removed from the clinical setting. A group of students, faculty members, and administrator... |
Coronavirus jolts labs to warp speed | To thwart SARS-CoV-2, labs hurry to hone assays, swap findings and share resources. |
A life immersed in science | |
Lack of MERS Coronavirus Neutralizing Antibodies in Humans, Eastern Province, Saudi Arabia | We used a lentiviral vector bearing the viral spike protein to detect neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) in persons from the Eastern Province of Saudi Arabia. None of the 268 samples tested displayed neutralizing activity, which suggests that MERS-CoV infections in h... |
Ecohealth research in Southeast Asia: past, present and the way forward | Ecohealth is a comprehensive approach to understanding health at its human, animal and environmental interface in a socio-ecological systems context. This approach was introduced widely in Southeast Asia (SEA) by the Canadian International Development Research Centre (IDRC) in the late 2000s. Aimed at addressing the pr... |
Discovery of Potential M2 Channel Inhibitors Based on the Amantadine Scaffold via Virtual Screening and Pharmacophore Modeling | The M2 channel protein on the influenza A virus membrane has become the main target of the anti-flu drugs amantadine and rimantadine. The structure of the M2 channel proteins of the H3N2 (PDB code 2RLF) and 2009-H1N1 (Genbank accession number GQ385383) viruses may help researchers to solve the drug-resistant problem of... |
El genoma humano. Límites y perspectivas en el avance de la medicina | |
Replication of respiratory viruses, particularly influenza virus, rhinovirus, and coronavirus in HuH7 hepatocarcinoma cell line | Detection of viral antigens and isolation methods has long been used for the diagnosis of respiratory virus infections. The objective was to determine the ability of HuH7 cells to support the replication of prototype and wild strains of respiratory viruses. The cell culture‐adapted strains of influenza viruses A and B,... |
Macrophages at the Fork in the Road to Health or Disease | |
Deletion Variants of Middle East Respiratory Syndrome Coronavirus from Humans, Jordan, 2015 | We characterized Middle East respiratory syndrome coronaviruses from a hospital outbreak in Jordan in 2015. The viruses from Jordan were highly similar to isolates from Riyadh, Saudi Arabia, except for deletions in open reading frames 4a and 3. Transmissibility and pathogenicity of this strain remains to be determined. |
Fetuin-A deficiency is associated with infantile cortical hyperostosis (Caffey disease) | BACKGROUND: Infantile cortical hyperostosis (ICH)/Caffey disease is an inflammatory collagenopathy of infancy, manifested by subperiosteal bone hyperplasia. Genetically, ICH was linked with heterozygosity for an R836C mutation in the COL1A1 gene. Although an autosomal-recessive trait is also suspected, it has not been ... |
A case series of Novel-Coronavirus infection in heart transplantation from two centers in the pandemic area in the North of Italy | |
Chilblain‐like lesions during COVID‐19 epidemic: a preliminary study on 63 patients | We have recently noticed an outbreak of chilblain-like lesions in Italy contemporarily to COVID-19 epidemic. Due to the well known lockdown-related difficulties to visit the patients1 we created a Google form aimed to collect information about patients presenting with these singular clinical findings. An easy to access... |
Influence of Obesity on Pneumococcus Infection Risk in the Elderly | Obesity negatively affects immune function and host defense mechanisms. Obesity is associated with chronic activation of the innate immune system and consequent local and systemic inflammation which contribute to pathologic conditions such as type-2 diabetes mellitus, cancer, psoriasis, atherosclerosis, and inflammator... |
Potential for global spread of a novel coronavirus from China | An epidemic of a novel coronavirus emerged from Wuhan, China, in late December 2019 and has since spread to several large Chinese cities. Should a scenario arise where this coronavirus spreads more broadly across China, we evaluate how patterns of international disease transmission could change. |
4 Cleaning and Disinfecting Gastrointestinal Endoscopy Equipment | Abstract Outbreaks of infection transmission due to contaminated flexible endoscopes have focused the attention of health care personnel, senior management, device manufacturers, and regulators on the need to improve the approach used to offer this valuable service. This chapter presents the principles of flexible endo... |
Pilgrims and MERS-CoV: what’s the risk? | The risk of Middle East Respiratory Syndrome Coronavirus spreading globally is worrying, given the annual mass gathering of the Hajj and the year-long influx of pilgrims undertaking the Umrah. Based on the incidence in Saudi Arabia since June 2012, the most likely scenario given recent pilgrim numbers is estimated to b... |
Celebrity, Pandemic, and Domesticity | |
Association of nausea with buprenorphine analgesia for rats | |
Identification of Pathogens by Mass Spectrometry | Background: Mass spectrometry (MS) is a suitable technology for microorganism identification and characterization. Content: This review summarizes the MS-based methods currently used for the analyses of pathogens. Direct analysis of whole pathogenic microbial cells using MS without sample fractionation reveals specific... |
Improved clinical and economic outcomes in severe bronchiolitis with pre-emptive nCPAP ventilatory strategy | PURPOSE: Severe bronchiolitis is the leading cause of admission to the pediatric intensive care unit (PICU). Nasal continuous positive airway pressure (nCPAP) has become the primary respiratory support, replacing invasive mechanical ventilation (MV). Our objective was to evaluate the economic and clinical consequences ... |
Emergence of Blue Sky Over Delhi Due to Coronavirus Disease (COVID-19) Lockdown Implications | Due to coronavirus pandemic (COVID-19) prevailing in more than 210 countries, out of them only few have promulgated lockdown and on March 24, 2020 India also implemented lockdown for 21 days to prevent the community spread of virus among people. Since then, lockdown heavily restricts travel movements of flights, rail, ... |
Human Influenza Virus Hemagglutinins Contain Conserved Oligomannose N-Linked Glycans Allowing Potent Neutralization by Lectins | Hemagglutinins (HAs) from human influenza viruses adapt to bind α2-6-linked sialosides, overcoming a receptor-defined species barrier distinct from the α2-3 specificity of avian virus progenitors. Additionally, human-adapted HAs gain glycosylation sites over time, although their biological function is poorly defined. U... |
Epidemic Influenza Seasons from 2008 to 2018 in Poland: A Focused Review of Virological Characteristics | The objective of this review was to elaborate on changes in the virological characteristics of influenza seasons in Poland in the past decade. The elaboration was based on the international influenza surveillance system consisting of Sentinel and non-Sentinel programs, recently adopted by Poland, in which professionals... |
Virus Life Cycle | Viruses are obligate intracellular parasites. Viruses must gain entry into target cells and usurp the host cellular machinery to produce a progeny virus. The multiple steps involved in the virus propagation occurring inside cells are collectively termed the “virus life cycle.” After entering the cell and localizing to ... |
Modalités pratiques de prise en charge des patients apnéiques par l’ORL durant l’épidémie de COVID-19 | Résumé La prise en charge des pathologies du sommeil a été fortement impactée par l’épidémie de COVID-19. La reprise des soins auprès de la population, à la sortie du confinement, va nécessiter des précautions visant à limiter les risques de contamination des patients et des soignants. L’Association Française du Sommei... |
Echocardiographic Findings in Covid-19 Pneumonia | The aim of this study was to characterize the echocardiographic phenotype of patients with Covid-19 pneumonia and its relation to biomarkers. Seventy-four patients (59±13 years, 78% male) admitted with Covid-19 were included after referral for transthoracic echocardiography (TTE) as part of routine care. A level 1 Brit... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.