IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P04629 | P19174 | 1 | phosphorylation | up-regulates | 0.652 | The nerve growth factor (ngf) receptor/trk associated with and phosphorylated phospholipase c gamma (plc gamma) | SIGNOR-38538 |
P62714 | Q12933 | 1 | dephosphorylation | down-regulates activity | 0.2 | We show that the Thr117 residue in TRAF2 is phosphorylated following TNFalpha stimulation. This phosphorylation process is modulated by PP2A and is required for TRAF2 functional activity. | SIGNOR-248597 |
Q96PV0 | Q9UQM7 | 0 | phosphorylation | up-regulates activity | 0.429 | Here we show that phosphorylation of synGAP by Ca(2+)/calmodulin-dependent protein kinase II increases its Ras GTPase-activating activity by 70-95%. The Major Phosphorylation Sites, Serines 764/765, 1058, and 1123, All Contribute to Regulation of GAP Activity of synGAP by CaMKII | SIGNOR-262687 |
Q13009 | P12931 | 0 | phosphorylation | up-regulates | 0.657 | Tiam1 cooperated with src to induce activation of rac1 in vivo and the formation of membrane ruffles. | SIGNOR-102354 |
P03372 | P51812 | 0 | phosphorylation | up-regulates | 0.403 | S6k1 regulates estrogen receptor alpha (eralpha) by phosphorylating it on serine 167, leading to transcriptional activation of eralpha. | SIGNOR-182958 |
P98170 | Q6GPH4 | 2 | binding | down-regulates | 0.558 | Immunoprecipitation studies indicate that xaf1 binds to xiap,birc2,birc3. | SIGNOR-155637 |
Q99075 | P00533 | 2 | binding | up-regulates | 0.768 | Ten growth factors and their erbb specificities are depicted: egf, amphiregulin((ar), and tgfalfa bind erbb-1, betacellulin, heparin binding egf-like growth factor, and epiregulin bing both erbb-1 and erbb-4 | SIGNOR-121977 |
Q9UL54 | P45985 | 2 | binding | up-regulates activity | 0.259 | Immunoprecipitated psk phosphorylates myelin basic protein and transfected psk stimulates mkk4 and mkk7 and activates the c-jun n-terminal kinase mitogen-activated protein kinase pathway. | SIGNOR-74864 |
O15111 | Q9Y618 | 1 | phosphorylation | down-regulates | 0.416 | Nf-kappab transcription requires ikkalpha to phosphorylate smrt on chromatin, stimulating the exchange of corepressor for coactivator complexes. Ikk directly phosphorylates smrt to stimulate nuclear export. Ikkalpha orchestrates smrt derepression, a prerequisite for nf-kappab transcription and survival. | SIGNOR-129956 |
P18848 | P49591 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269424 |
P31431 | P63000 | 2 | binding | up-regulates activity | 0.503 | Rac1 is associated with Sdc4 and is activated by FN binding […] We observed that over-expression of Fzd7, or stimulation with FN resulted in increased levels of active Rac1 in primary myoblasts | SIGNOR-255849 |
P04626 | P17612 | 0 | phosphorylation | up-regulates | 0.405 | Pka directly phosphorylated erbb2 on thr-686, a highly conserved intracellular regulatory site that was required for the pka-mediated synergistic enhancement of neuregulin-induced erbb2-erbb3 activation and proliferation in scs. | SIGNOR-181191 |
Q96EP1 | Q12824 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.316 | Here we report that CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway, and that SRG3/mBAF155 stabilizes these components by blocking their interaction with CHFR. These results suggest that CHFR enhances the d... | SIGNOR-271458 |
Q9Y4K3 | O75385 | 1 | ubiquitination | up-regulates quantity by stabilization | 0.548 | AMBRA1, interacting with the E3-ligase TRAF6, supports ULK1 ubiquitylation by LYS-63-linked chains, and its subsequent stabilization, self-association and function. | SIGNOR-273000 |
P02649 | P98155 | 2 | binding | up-regulates | 0.635 | Several ligands for the vldl receptor have been identified in addition to tfpi. These include apolipoprotein e (apoe) | SIGNOR-106221 |
P21583 | P10721 | 2 | binding | up-regulates activity | 0.934 | The most relevant and still unique mast-cell growth factor is SCF, which is the ligand of KIT, a receptor with tyrosine-kinase activity that is expressed on the surface of all human and murine mast cells | SIGNOR-254946 |
P43405 | Q96P31 | 2 | binding | up-regulates activity | 0.353 | Tyrosine phosphorylation of SPAP2a by c-Src and in vitro. Tyrosine-phosphorylated SPAP2 is specifically associated with SH2 domain-containing tyrosine kinases Syk and Zap70 and SH2 domain-containing tyrosine phosphatases SHP-1 and SHP-2. Site-specific mutagenesis studies revealed that tyrosyl residues 650 and 662 embed... | SIGNOR-274011 |
P12931 | O14874 | 1 | phosphorylation | up-regulates activity | 0.2 | Src phosphorylated BCKDK at the tyrosine 246 (Y246) site in vitro and ex vivo. Knockdown and knockout of Src downregulated the phosphorylation of BCKDK. Importantly, phosphorylation of BCKDK by Src enhanced the activity and stability of BCKDK, thereby promoting the migration, invasion, and EMT of CRC cells. | SIGNOR-275583 |
P42345 | Q8N122 | 1 | phosphorylation | up-regulates activity | 0.989 | The phosphorylation of raptor is stimulated by insulin and inhibited by rapamycin. Importantly, the site-directed mutation of raptor at one phosphorylation site, Ser(863), reduced mTORC1 activity both in vitro and in vivo. | SIGNOR-184959 |
P19429 | P05771 | 0 | phosphorylation | down-regulates | 0.2 | Pkc-betaii sensitizes cardiac myofilaments to ca2+ by phosphorylating troponin i on threonine-144. | SIGNOR-149957 |
P08246 | P25116 | 1 | cleavage | up-regulates activity | 0.43 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263565 |
O14980 | P04637 | 1 | relocalization | down-regulates activity | 0.549 | We identify the major poly(ADP-ribosyl)ated sites of p53 by PARP-1 and find that PARP-1-mediated poly(ADP-ribosyl)ation blocks the interaction between p53 and the nuclear export receptor Crm1, resulting in nuclear accumulation of p53. These findings molecularly link PARP-1 and p53 in the DNA-damage response, providing ... | SIGNOR-260067 |
P27986 | P36897 | 2 | binding | up-regulates | 0.381 | These studies revealed that PI 3-kinase is associated in vivo with both TGF-_ receptor subtypes and that TGF-_1 stimulation enhances PI 3-kinase activity associated with type I TGF-_ receptor in hASM cells. | SIGNOR-227525 |
Q02548 | P03206 | 2 | binding | down-regulates activity | null | ... we demonstrate that Pax5 inhibits Z-mediated lytic viral gene expression and the release of infectious viral particles in latently infected epithelial cell lines. Conversely, we found that shRNA-mediated knockdown of endogenous Pax5 in a Burkitt lymphoma B-cell line leads to viral reactivation. Furthermore, we show... | SIGNOR-269082 |
Q9NWB1 | P51608 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.28 | MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. | SIGNOR-264681 |
O94988 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.435 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260502 |
P24941 | Q8IXJ6 | 1 | phosphorylation | down-regulates | 0.395 | We define ser-331 as the site phosphorylated by cyclin e-cdk2, cyclin a-cdk2, and p35-cdk5 both in vitro and in cells. Importantly, phosphorylation at ser-331 inhibits the catalytic activity of sirt2. | SIGNOR-177972 |
Q9BYT3 | Q9BYT3 | 2 | phosphorylation | up-regulates activity | 0.2 | Our results show that the serine/threonine kinase Stk33 phosphorylates the intermediate filament protein vimentin in vitro specifically in the vimentin head domain. Stk33 undergoes obligatory autophosphorylation, which might be a prerequisite for its kinasing activity. | SIGNOR-272957 |
P30556 | P01019-PRO_0000032458 | 2 | binding | up-regulates activity | 0.2 | Ang II initiates most of the RAS-attributed physiologic effects through selective interactions with G-proteincoupled Ang II type 1 (AT1) or type 2 (AT2) receptors and subsequent activation of distinct intra cellular signaling pathways | SIGNOR-260238 |
Q16875 | P31749 | 0 | phosphorylation | up-regulates | 0.427 | We also found that AMP activated protein kinase and protein kinases A, B, and C catalyzed the phosphorylation of Ser-460 of HBP1, and that in addition both isoforms are phosphorylated at a second, as yet undetermined site by protein kinase C. However, none of the phosphorylations had any effect on the intrinsic kinetic... | SIGNOR-252477 |
Q15797 | P35813 | 0 | dephosphorylation | down-regulates | 0.538 | In this study, we have found that ppm1a, a metal ion-dependent protein serine/threonine phosphatase, physically interacts with and dephosphorylates smad1 both in vitro and in vivo. considering the highly conserved nature of the sxs motif in all r-smads, we reasoned that ppm1a might also recognize the sxs motif in the ... | SIGNOR-149077 |
P46527 | Q13131 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.267 | P27Kip1-Mediated Cell Survival Is Dependent on AMPK-Specific Thr198 Phosphorylation|AMPK-dependent phosphorylation of p27Kip1 on Thr198 promotes p27Kip1 protein stability, resulting in more autophagy and less apoptosis. | SIGNOR-259859 |
P98170 | P55211 | 2 | binding | down-regulates quantity by destabilization | 0.922 | A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis | SIGNOR-105702 |
Q13049 | O96017 | 0 | phosphorylation | up-regulates activity | 0.2 | We show that CHK2 binds and phosphorylates TRIM32 at the S55 site, which then mediates K63-linked ubiquitination of ATG7 at the K45 site to initiate autophagy. | SIGNOR-277790 |
P17252 | Q96PH1 | 1 | phosphorylation | up-regulates | 0.2 | A constitutively active form of pkc? Robustly increased basal and pma-stimulated nox5 activity and promoted the phosphorylation of nox5 on ser490, thr494, and ser498. | SIGNOR-204550 |
P69905 | P17509 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | HOXB6 protein represses globin transcript levels in stably transfected K562 cells in a DNA-binding dependent fashion. | SIGNOR-261637 |
P25054 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.2 | APC is Phosphorylated by PKCdelta in Intact RKO Cells. | SIGNOR-279650 |
P05771 | P48736 | 1 | phosphorylation | up-regulates activity | 0.501 | Remarkably we find that PKCβ phosphorylates Ser582 in the helical domain of the PI3Kγ catalytic subunit p110γ in response to clustering of the high-affinity IgE receptor (FcεRI) and/or store-operated Ca²⁺- influx in mast cells. Phosphorylation of p110γ correlates with the release of the p84 PI3Kγ adapter subunit from ... | SIGNOR-276496 |
Q9GZV5 | Q4VCS5 | 0 | relocalization | down-regulates | 0.678 | Yap/taz and angiomotin (amot) family proteins were shown to interact, resulting in yap/taz localization to tight junctions and inhibition through phosphorylation-dependent and -independent mechanisms. | SIGNOR-201132 |
Q8N726 | Q13535 | 1 | phosphorylation | up-regulates activity | 0.391 | Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressorInduction of ATR activity in Hs68 E2F1ER cells by endogenous ARF. | SIGNOR-134781 |
P41235 | P12931 | 0 | phosphorylation | down-regulates | 0.365 | Here we show that c-src phosphorylates human hnf4_ on three tyrosines phosphomimetic mutants in the lbd decrease p1-hnf4_ protein stability, nuclear localization and transactivation function. | SIGNOR-195896 |
Q9HBT6 | P35222 | 2 | binding | up-regulates activity | 0.297 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265859 |
P45984 | P54259 | 1 | phosphorylation | down-regulates activity | 0.2 | Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-jun nh2-terminal kinase. serine 734 of the drpla protein is a phospho-acceptor site by jnk. The phosphorylation may be coupled to the activation of a protease. The molecular size of drpla protein detected in the rat brain with the specific phosphopepti... | SIGNOR-102402 |
Q14493 | Q71DI3 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265414 |
Q7Z6J0 | P31751 | 0 | phosphorylation | down-regulates | 0.389 | Overexpression of posh induces apoptosis in a variety of cell types, but apoptosis can be prevented by co-expressing the pro-survival protein kinase akt. We report here that posh is a direct substrate for phosphorylation by akt in vivo and in vitro, and we identify a major site of akt phosphorylation as serine 304 of p... | SIGNOR-155233 |
P50570 | Q9Y5X1 | 2 | binding | up-regulates | 0.812 | Snx9 binds directly to bothdynamin-1 anddynamin-2. Moreover by stimulatingdynaminassembly, snx9 stimulatesdynamin's basal gtpase activity and potentiates assembly-stimulated gtpase activity on liposomes. | SIGNOR-133976 |
P62873 | Q9Y4H4 | 2 | binding | down-regulates quantity by destabilization | 0.385 | GPSM3 was found not only to modulate heterotrimeric G-protein subunit signaling through its two active GoLoco motifs, but also to affect monomeric Gbeta subunit biosynthesis and stability|interactions between GPSM3 and Galphai1 or Gbeta1 (20) was assayed by BRET. | SIGNOR-264865 |
O43561 | P06239 | 0 | phosphorylation | up-regulates | 0.758 | Evidence of lat as a dual substrate for lck and syk in t lymphocytes.Lat is a linker protein essential for activation of t lymphocytes. Its rapid tyrosine-phosphorylation upon t cell receptor (tcr) stimulation recruits downstream signaling molecules for membrane targeting and activation. | SIGNOR-149182 |
Q99640 | P53350 | 0 | phosphorylation | down-regulates activity | 0.721 | Here, we have shown that Plk1 is responsible for part of the phosphorylation of Myt1 during M phase. The kinase activity of human Myt1 is reported to be decreased during M phase, and the decreased activity correlates with hyperphosphorylated forms of Myt1 (35, 37). We then tested the ability of these mutant forms of M... | SIGNOR-263096 |
P12270 | P28482 | 0 | phosphorylation | up-regulates | 0.374 | Tpr is phosphorylated by erk2 at four different sites. / because phosphorylation of tpr by activated erk stabilizes their interaction, we hypothesize that this phosphorylation is not part of a signal amplification cascade but rather positions activated erk to perform a continuing function in the nuclear pore. | SIGNOR-181022 |
Q15796 | O14595 | 0 | dephosphorylation | down-regulates activity | 0.445 | Dephosphorylation of Smad2/3 Linkers by SCP2 and SCP3|MAPK-mediated linker phosphorylation appears to have a dual role in Smad2/3 regulation. Mitogens and hyperactive Ras result in extracellular signal-regulated kinase (ERK)-mediated phosphorylation of Smad3 at Ser-204, Ser-208, and Thr-179 and of Smad2 at Ser-245/250/... | SIGNOR-248299 |
P17612 | P15056 | 1 | phosphorylation | down-regulates activity | 0.635 | Direct phosphorylation of B-Raf by PKA exerts a negative effect on its kinase activity, essentially via phosphorylation of Ser429 | SIGNOR-250339 |
P23470 | P18206 | 1 | dephosphorylation | down-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254731 |
O95251 | Q7Z6Z7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Moreover, we determined that Huwe1 is a novel E3 ligase for Myst2 degradation in mESCs, and Brpf3 disturbs Huwe1 mediated ubiquitination of Myst2 via interaction with Huwe1 and Myst2. | SIGNOR-278652 |
P17252 | P23528 | 1 | phosphorylation | down-regulates | 0.2 | Pkc_ phosphorylates cofilin at ser-23 and/or ser-24 during degranulationthese results indicate that a novel pkc_-mediated phosphorylation event regulates cofilin by inhibiting its ability to depolymerize f-actin and bind to 14-3-3_, thereby promoting f-actin polymerization | SIGNOR-198478 |
P01112 | P42338 | 2 | binding | up-regulates activity | 0.759 | Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. it was also described that ras interacts with pi3k in a direct manner. | SIGNOR-175189 |
P19174 | P12931 | 0 | phosphorylation | up-regulates activity | 0.636 | The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated ... | SIGNOR-247316 |
Q15418 | Q15653 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.369 | By using recombinant wild-type and mutant IkappaBbeta proteins, both active ERK2 and RSK1 were found to directly phosphorylate IkappaBbeta, but only active RSK1 phosphorylated IkappaBbeta on Ser19 and Ser23, two sites known to mediate the subsequent ubiquitination and degradation. | SIGNOR-280114 |
Q8IWA4 | Q9UKV5 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.309 | Gp78 induces ubiquitylation and proteasomal degradation of Mfn1 and Mfn2. | SIGNOR-272886 |
O76064 | Q14676 | 0 | relocalization | up-regulates | 0.757 | Rnf8 relocalizes to dna damage sites via a phospho-dependent interaction with mdc1 | SIGNOR-179820 |
P67775 | Q08999 | 1 | dephosphorylation | up-regulates | 0.581 | Pocket protein family consists of the retinoblastoma tumor suppressor protein (prb) and the functionally and structurally related proteins p107 and p130./dephosphorylation of p130 and p107 in cell extracts is inhibited by concentrations of okadaic acid known to inhibit pp2a, but not pp1. Finally, the pp2a catalytic sub... | SIGNOR-129752 |
Q9NPF7 | P42701 | 2 | binding | up-regulates | 0.645 | Like il-12, il-23 binds to the il-12r subunit il-12rbeta1. | SIGNOR-87739 |
P27361 | Q8TB45 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.282 | Screening the DEPTOR interactome identified that the association of USP-7 deubiquitinase with DEPTOR was dependent upon S235 phosphorylation. Inhibition of USP-7 activity resulted in DEPTOR polyubiquitination and degradation. A scansite search suggested that ERK1 may be responsible for S235 phosphorylation, which was c... | SIGNOR-277587 |
P35712 | Q00535 | 0 | phosphorylation | down-regulates quantity | 0.366 | GST-Sox6 was phosphorylated in vitro by Cdk5 and p35 (XREF_FIG).|Inhibition of Cdk5 activity by DN Cdk5 and roscovitine increases the Sox6 expression in primary cortical neurons. | SIGNOR-279365 |
Q13523 | P19419 | 1 | phosphorylation | up-regulates | 0.2 | Activated hprp4 phosphorylates residue thr-417 on elk-1 resulting in elk-1 activation. | SIGNOR-77135 |
P60484 | Q86TM6 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Secondly, HRD1 promotes PTEN ubiquitination and degradation. | SIGNOR-278724 |
P45983 | P01106 | 1 | phosphorylation | up-regulates activity | 0.556 | The jnk pathway is selectively involved in the c-myc-mediated apoptosis and that the apoptotic function of c-myc is directly regulated by jnk pathway through phosphorylation at ser-62 and ser-71. | SIGNOR-236018 |
Q13480 | Q06124 | 0 | dephosphorylation | down-regulates activity | 0.952 | These results suggest that Tyr(P)-627 and Tyr(P)-659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) that binds and activates SHP2.|Thus, physical association of activated SHP2 with Gab1 is necessary and sufficient to mediate the ERK mitogen-activated protein kinase activation. Phosphopeptides... | SIGNOR-248674 |
O15379 | P12830 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.257 | GATA1 is a new substrate of p21-activated kinase 5 (PAK5), which is phosphorylated on serine 161 and 187 (S161 and S187). GATA1 recruits HDAC3/4 to E-cadherin promoter, which is reduced by GATA1 S161A S187A mutant. These data indicate that phosphorylated GATA1 recruits more HDAC3/4 to promote transcriptional repression... | SIGNOR-275662 |
Q9UGL1 | Q99814 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.283 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271578 |
P34972 | P08754 | 2 | binding | up-regulates activity | 0.452 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256843 |
Q9C0B5 | Q15910 | 1 | palmitoylation | down-regulates activity | 0.2 | Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y. These events contributed to the development of glioma by promoting the self-renewal capacity and tumorigenicity of glioma stem-like cells, by altering the palmitoylation and phospho... | SIGNOR-261144 |
Q969H0 | Q14258 | 0 | ubiquitination | down-regulates activity | 0.264 | This newly stabilized TRIM25 then directly ubiquitinates Lys412 of FBXW7α, a core subunit of the SKP1-Cullin-F-box (SCF) ubiquitin ligase complex involved in Myc ubiquitination, thereby stabilizing Myc. | SIGNOR-277457 |
P42224 | Q13555 | 0 | phosphorylation | up-regulates activity | 0.507 | For maximal gene activation, S727 in the transcription activation domain of Stat1 also is inducibly phosphorylated by IFN-gamma. We previously purified a group of nuclear proteins that interact specifically with the Stat1 transcription activation domain. In this report, we identified one of them as the multifunctional ... | SIGNOR-250706 |
O14625 | P49682 | 2 | binding | up-regulates activity | 0.777 | The chemokines CXCL9, 10, and 11 exert their action via CXC chemokine receptor-3 (CXCR3), a receptor highly expressed on activated T cells. | SIGNOR-260971 |
Q96RR4 | P53355 | 0 | phosphorylation | down-regulates | 0.283 | Dapk phosphorylates camkk. S511 was identified as the phosphorylation site . a potential mechanism of action was identified on the basis of the location of s511 near the cam recognition domain of camkk and demonstrated by attenuation of cam-stimulated camkk autophosphorylation after dapk phosphorylation. | SIGNOR-126241 |
Q9UKP6 | P63096 | 2 | binding | up-regulates activity | 0.265 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257051 |
P04629 | P29353 | 2 | binding | up-regulates | 0.844 | Autophosphorylated trka binds directly to plc?, Abl, and shc. | SIGNOR-75408 |
Q96E17 | Q86UR5 | 0 | relocalization | up-regulates activity | 0.416 | N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle | SIGNOR-264382 |
Q8NFZ4 | P58401 | 2 | binding | up-regulates activity | 0.829 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264161 |
P49810 | Q8WW43 | 2 | binding | up-regulates | 0.909 | By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain. | SIGNOR-93310 |
Q15475 | P15311 | 1 | transcriptional regulation | up-regulates quantity | 0.342 | We now show that the gene encoding Ezrin is a direct transcriptional target of Six1. | SIGNOR-259374 |
Q16236 | P00441 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.408 | BTG2 was found to up-regulate expression of antioxidant enzymes known to be regulated by NFE2L2, including catalase, SOD1, and SOD2 | SIGNOR-254653 |
Q9Y5Q3 | P54821 | 2 | binding | down-regulates activity | 0.306 | Hoxd12 and MHox, that interact with v-/c-Maf, using the phage display method. The Hox proteins also could associate with the other Maf protein family members, MafB, MafK, MafF, and MafG, but not with Jun and Fos. The Hox proteins negatively regulated the DNA binding, transactivation and cell-transforming abilities of M... | SIGNOR-221899 |
P01127 | P16234 | 2 | binding | up-regulates activity | 0.718 | Pdgf-b activates both pdgfr-alpha and pdgfr-beta | SIGNOR-107397 |
P20671 | Q14493 | 0 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265399 |
Q05655 | P25098 | 1 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin. In vitro, GRK2 was preferentially phosphorylated by PKC isoforms alpha, gamma, and delta. Two-dimensional peptide mapping of PKCalpha-phosphorylated GRK2 showed a single site of phosphorylation, which was identified as serine 29 by HPLC... | SIGNOR-249059 |
P35236 | Q04759 | 0 | phosphorylation | up-regulates activity | 0.2 | PKC θ is required for HePTP translocation to the immune synapse. PKC θ phosphorylates HePTP at S225 in primary T cells. | SIGNOR-276045 |
Q16236 | Q05655 | 0 | phosphorylation | up-regulates activity | 0.371 | Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. | SIGNOR-249161 |
Q7Z6Z7 | Q9C0C7 | 0 | relocalization | up-regulates activity | 0.2 | AMBRA1 regulates mitophagy at two critical steps. Upon mitophagy stimulation, AMBRA1 mediates the HUWE1 E3 ubiquitin ligase translocation from cytosol to mitochondria (light blue). AMBRA1 acts as a cofactor for HUWE1 E3 ubiquitin ligase activity, favouring its binding to its substrate MFN2 (and maybe other OMM substrat... | SIGNOR-272962 |
Q8TD19 | Q9HC98 | 1 | phosphorylation | up-regulates activity | 0.69 | Nercc1/nek9 activates the nek6 and nek7 kinases. Nercc1 catalyzes the direct phosphorylation of prokaryotic recombinant nek6 at ser206 in vitro concomitant with 20-25-fold activation of nek6 activity. | SIGNOR-102996 |
P35659 | O43791 | 2 | binding | down-regulates quantity by destabilization | 0.438 | Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative fashion. Of these, DEK and TRIM24 emerged as effector substrates consistentl... | SIGNOR-272826 |
P04090 | Q8WXD0 | 2 | binding | up-regulates | 0.708 | Lgr7 and lgr8, are capable of mediating the action of relaxin through an adenosine 3',5'-monophosphate (camp)-dependent pathway. | SIGNOR-114585 |
P60520 | Q96A56 | 2 | binding | up-regulates | 0.38 | In this work, we show that tp53inp1 is also able to interact with atg8-family proteins and to induce autophagy-dependent cell death. mammalian cells contain multiple atg8 orthologs belonging to three subfamilies: microtubule-associated protein 1 light chain 3, -aminobutyric acid receptor-associated protein (gabarap) a... | SIGNOR-196667 |
Q99704 | P26012 | 2 | binding | down-regulates activity | 0.2 | Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation | SIGNOR-257698 |
P30989 | P09471 | 2 | binding | up-regulates activity | 0.274 | Altogether, these results reveal for the first time the ability of hNTS1 to directly activate the Gαq-, Gαi1-, GαoA-, and Gα13-mediated signaling pathways | SIGNOR-278061 |
Q8TF76 | P53350 | 2 | binding | up-regulates activity | 0.2 | Phosphorylation by Cyclin B-Cdk1 allows Haspin to bind Plk1-PBD. Phosphorylation of Haspin at T128 and Plk1 target sites is required for full H3T3ph generation and normal Aurora B localization in mitosis. | SIGNOR-275420 |
Q9UQ13 | P17252 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | PKCalpha/delta phosphorylate Sur8 at Thr-71 and Ser-297, respectively. This phosphorylation is essential for polyubiquitin-dependent degradation of Sur8. | SIGNOR-275568 |
Q05397 | Q9Y490 | 2 | binding | up-regulates activity | 0.688 | Focal adhesion kinase (FAK) is activated by growth factors and integrins during migration, and functions as a receptor-proximal regulator of cell motility. At contacts between cells and the extracellular matrix, FAK functions as an adaptor protein to recruit other focal contact proteins or their regulators, which affec... | SIGNOR-257731 |
Q05655 | P17405 | 1 | phosphorylation | up-regulates | 0.256 | Activation of acid sphingomyelinase by protein kinase cdelta-mediated phosphorylation. Phosphorylation of ser(508) proved to be an indispensable step for asmase activation and membrane translocation in response to pma | SIGNOR-153276 |
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