IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
O95486 | Q9NR31 | 2 | binding | up-regulates quantity | 0.756 | Biogenesis of COPII vesicles is initiated by the activation of the small guanosine triphosphate (GTP)-binding protein secretion-associated Ras-related protein 1 (Sar1) at specialized subdomains of the ER, called ER exit sites (ERES) or transitional ER (tER). Membrane-bound Sar1 then recruits the inner COPII coat subcom... | SIGNOR-265303 |
Q86YT6 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.325 | Similar to the mechanism of PAR-1 regulation of Mib in neurogenesis, CDK5 phosphorylation is proposed to enhance Mib1 ligase activity leading to destabilization.|The cyclin dependent kinase 5 (CDK5) enriched in neurons phosphorylates Mib1 and suppresses the inhibitory effects of Mib1 on neurite morphology. | SIGNOR-280217 |
P17252 | P08581 | 1 | phosphorylation | down-regulates | 0.256 | These data show that phosphorylation of ser985 is a key mechanism for the negative regulation of hgf/sf receptor. | SIGNOR-37718 |
P60484 | O15327 | 0 | dephosphorylation | down-regulates activity | 0.632 | In support, the increase in PTEN caused by INPP4B knockdown was associated with increased phosphorylation of the Ser380, Thr382, Thr383 and Ser385 cluster of the protein (XREF_FIG), which is known to increase PTEN half-life, in colon cancer cells.|Exogenous INPP4B could pull down and dephosphorylate endogenous PTEN, su... | SIGNOR-277018 |
P21802 | P05230 | 2 | binding | up-regulates | 0.909 | We have crystallized a complex between human FGF1 and a two-domain extracellular fragment of human FGFR2. | SIGNOR-73811 |
Q9Y3M8 | P61586 | 1 | gtpase-activating protein | down-regulates activity | 0.645 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260521 |
P19784 | P42768 | 1 | phosphorylation | up-regulates activity | 0.347 | We identify two phosphorylation sites in the VCA domain of WASP at serines 483 and 484. S483 and S484 are substrates for casein kinase 2 in vitro and in vivo. Phosphorylation of these residues increases the affinity of the VCA domain for the Arp2/3 complex 7-fold and is required for efficient in vitro actin polymerizat... | SIGNOR-251048 |
Q13131 | Q8N5S9 | 0 | phosphorylation | up-regulates | 0.462 | Ampka1 activators increased phosphorylation level and cytoplasmic localization (reduced nuclear/cytoplasmic ratio). Ampka1 activators reduced rna synthesis in the nucleoli. | SIGNOR-176598 |
Q96EQ8 | Q9BYX4 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.657 | Here, we found that RIG-I undergoes proteasomal degradation after conjugation to ubiquitin by RNF125. Further, RNF125 conjugates ubiquitin to MDA5, a family protein of RIG-I as well as IPS-1, which is also a downstream protein of RIG-I signaling that results in suppressing the functions of these proteins. Because RNF12... | SIGNOR-271646 |
O96013 | P17676 | 1 | phosphorylation | up-regulates activity | 0.2 | Importantly, we found that PAK4 enhanced CEBPB phosphorylation on Thr 235.|In summary, we showed that PAK4 mediated CEBPB activation upregulated CLDN4 expression to promote breast cancer cell migration and invasion. | SIGNOR-280055 |
Q9HBW0 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257324 |
P63096 | Q8TDV5 | 2 | binding | up-regulates activity | 0.278 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257040 |
P27707 | P67775 | 0 | dephosphorylation | down-regulates activity | 0.2 | Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation|Deoxycytidine kinase (dCK) is a critical enzyme for activation of anticancer nucleoside analogs. Its activity is controlled via Ser-74 phosphorylation. Here, we investigated which Ser/Thr phosphatase dephosphorylates Ser-74. In ... | SIGNOR-275803 |
P17252 | Q9UJY1 | 1 | phosphorylation | up-regulates activity | 0.307 | Hsp22 is phosphorylated by protein kinase c (at residues ser(14) and thr(63)) and by p44 mitogen-activated protein kinase (at residues ser(27) and thr(87)). Concerning the possible function of hsp22, no definitive conclusions can be drawn with the available data, although its function might be to bind to and modulate t... | SIGNOR-107688 |
P10275 | Q13772 | 2 | binding | up-regulates | 0.86 | We demonstrated that ara70 and ar physically interact and that ara70 can function as an androgen-dependent coactivator for ar. | SIGNOR-67684 |
Q92934 | P04637 | 2 | binding | up-regulates activity | 0.328 | We also demonstrate that bad physically interacts with cytoplasmic p53. bad is able to direct p53 to the mitochondria and forms a p53/bad complex at the mitochondria. the mitochondrial p53/bad complex promotes apoptosis | SIGNOR-149815 |
O43918 | Q05084 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.362 | Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. | SIGNOR-268973 |
Q05086 | O94788 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Hyperactivity of E3 ubiquitin (Ub) ligase UBE3A, stemming from 15q11-q13 copy number variations, accounts for 1%-3% of ASD cases worldwide, but the underlying mechanisms remain incompletely characterized. Here we report that the functionality of ALDH1A2, the rate-limiting enzyme of retinoic acid (RA) synthesis, is nega... | SIGNOR-265135 |
Q05086 | P49815 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.629 | An in vivo ubiquitination assay was done to reveal that E6AP promoted the ubiquitination of TSC2 independent of HPV16 E6. We further found that TSC2 bound E6AP in the presence as well as in the absence of HPV16 E6. The binding regions on E6AP and TSC2 have been identified as amino acid (aa) 260-316, aa 428-500 and aa ... | SIGNOR-271396 |
Q8IXJ6 | P15259 | 1 | deacetylation | up-regulates activity | 0.2 | Here we report that PGAM is acetylated at lysine 100 (K100), an active site residue that is invariably conserved from bacteria, to yeast, plant, and mammals. K100 acetylation is detected in fly, mouse, and human cells and in multiple tissues and decreases PGAM2 activity. The cytosolic protein deacetylase sirtuin 2 (SIR... | SIGNOR-266518 |
O14737 | P68400 | 0 | phosphorylation | up-regulates | 0.2 | Programmed cell death 5 (pdcd5), a protein involved in cell death and down-regulated in different forms of human tumors. Pdcd5 is phosphorylated in vitro by both ck2alpha subunit and by the ck2 holoenzyme at a residue, s118, which is found phosphorylated in vivo. Transfection of the non-phosphorylatable mutant (s118a) ... | SIGNOR-187106 |
P06239 | Q9UJZ1 | 2 | binding | up-regulates activity | 0.2 | In these studies, we also found that SLP-2 interacted with Lck, ZAP70, LAT, and PLC-gamma1 during the 30-min period following stimulation in vitro|The SLP-2-associated pool of these molecules became phosphorylated/activated in a sequential manner, a profile compatible with their temporal involvement in early TCR signal... | SIGNOR-260376 |
P30307 | P43405 | 0 | phosphorylation | down-regulates activity | 0.36 | SYK Phosphorylates CDC25C on Serine 216.|We now provide new genetic and biochemical evidence that SYK is an inhibitor of CDC25C in B-lineage lymphoid cells as well as non lymphohematopoietic cells, that prevents premature entry into mitosis by phosphorylating CDC25C at S216 when G 2 checkpoint responses are activated. | SIGNOR-278328 |
Q70Z35 | P60953 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.423 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260572 |
O60486 | O75326 | 2 | binding | up-regulates | 0.913 | Plexin-c1 is a receptor for the gpi-anchored semaphorin sema7a. The cytoplasmic domain of plexins associates with a tyrosine kinase activity. Plexins may also act as ligands mediating repulsion in epithelial cells in vitro. | SIGNOR-71260 |
Q9NRM7 | Q4VCS5 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.516 | Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, u... | SIGNOR-275846 |
P15391 | P07948 | 2 | binding | up-regulates activity | 0.772 | CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a mem... | SIGNOR-242894 |
Q86YT6 | Q86YT6 | 2 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | The RING finger motifs of DIP-1 have E3 ligase activity that can auto-ubiquitinate DIP-1 in vitro. In vivo, DIP-1 is detected as a polyubiquitinated protein, suggesting that the intracellular levels of DIP-1 are regulated by the ubiquitin-proteasome system. | SIGNOR-272603 |
P04150 | Q16649 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.296 | GR directly regulates transcription of circadian clock components in mouse and human primary MSCs. Per2, E4bp4, Per1, and Timeless rapidly respond to glucocorticoid stimulation. Primary glucocorticoid receptor (GR) target genes are those at which GR occupies a nearby genomic glucocorticoid response element (GRE) and re... | SIGNOR-268051 |
O75385 | Q15437 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Here, we show that the F-box protein FBXW5 targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients. In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, i... | SIGNOR-265285 |
P84243 | Q09472 | 0 | acetylation | down-regulates activity | 0.2 | These results highlight the substrate and site specificities of hats in cells, demonstrate the distinct roles of gcn5/pcaf- and cbp/p300-mediated histone acetylations in gene activation, and suggest an important role of cbp/p300-mediated h3k18/27ac in nr-dependent transcription. | SIGNOR-170266 |
P49137 | P28482 | 0 | phosphorylation | up-regulates | 0.507 | Using novel methodology we demonstrate that activation of mapkap kinase-2 requires the phosphorylation of any two of the three residues thr222, ser272 and thr334. gst-mapkap kinase-2 lacking the n-terminal domain was inactive, but activated fully when phosphorylated at thr222, ser272 and thr334 by p42 mapk or rk. | SIGNOR-44343 |
P05412 | Q969H0 | 2 | binding | down-regulates quantity by destabilization | 0.495 | We report that in neurons the stability of c-Jun is regulated by the E3 ligase SCF(Fbw7), which ubiquitinates phosphorylated c-Jun and facilitates c-Jun degradation. | SIGNOR-272950 |
Q5VWQ8 | P27986 | 2 | binding | down-regulates activity | 0.283 | DAB2IP binds the p85 subunit of PI3K through its PR domain and prevents PI3K-p85 relocation from the cytoplasm to the membrane, a necessary step for PI3K activation and signaling to AKT. Notably, DAB2IP reinforces this inhibitory effect by directly binding AKT.2 | SIGNOR-254757 |
P26992 | Q9UBD9 | 2 | binding | up-regulates | 0.702 | Striking phenotypic differences between cntf- and cntfr-deficient mice suggest that cntfr serves as a receptor for a second, developmentally important ligand. We have identified this factor as a stable secreted complex of cardiotrophin-like cytokine (clc) and the soluble receptor cytokine-like factor-1 (clf). | SIGNOR-81376 |
Q09472 | P15172 | 1 | acetylation | up-regulates | 0.681 | Our results provide direct evidence that myod acetylation functionally activates the protein and show that both pcaf and cbp/p300 are candidate enzymes for myod acetylation in vivo. | SIGNOR-81053 |
Q92886 | Q13164 | 0 | phosphorylation | up-regulates activity | 0.35 | Activation of ERK5 potentiates while inhibition of ERK5 attenuates Neurog1 stimulated neurogenesis.|ERK5 directly phosphorylated Neurog1 in vitro and modulated the transcriptional and pro-neural activity of Neurog1 in cortical progenitors. | SIGNOR-278364 |
P06213 | Q12923 | 0 | dephosphorylation | down-regulates | 0.26 | We demonstrate that ptpl1, like ptp1b, interacts with and dephosphorylates a bis-phosphorylated insulin receptor peptide more efficiently than monophosphorylated peptides, indicating that ptpl1 may down-regulate the phosphatidylinositol 3-kinase pathway, by dephosphorylating insulin or growth factor receptors that cont... | SIGNOR-132555 |
O60260 | Q9NX09 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | In conclusion, our work in cellular and animal models and in human samples strongly indicates that RTP801 is a substrate of parkin and that RTP801 elevation due to parkin loss of function in both AR-JP and sporadic Parkinson's disease may contribute to neurodegeneration.|We showed that parkin poly-ubiquitinates RTP801,... | SIGNOR-278560 |
P08254 | Q9ULU4 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported | SIGNOR-262043 |
O76064 | P0C0S8 | 1 | ubiquitination | up-regulates | 0.2 | Rnf8 and ubc13 ubiquitylate h2a and h2ax, but other substrates probably exist. | SIGNOR-166174 |
Q05397 | O75962 | 1 | phosphorylation | up-regulates activity | 0.509 | A FAK phosphorylation site, tyrosine residue 2737, was identified in subdomain I of the Trio kinase domain. Additionally, in vitro phosphorylation assays and in vivo co-expression studies indicated that Trio enhances FAK kinase activity. | SIGNOR-249188 |
P63000 | Q7Z6I6 | 0 | gtpase-activating protein | down-regulates activity | 0.403 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260486 |
P20042 | P49770 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.751 | EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. | SIGNOR-269130 |
P00747 | P02749 | 1 | cleavage | down-regulates activity | 0.458 | Plasmin can reduce the function of human beta2 glycoprotein I by cleaving domain V into a nicked form| The cleavage site of r-Domain V and beta2GPI by plasmin was proved to be Lys 317-Thr 318 by amino acid sequence analysis of the digest and of the C-terminal peptide isolated by high-performance liquid chromatography. ... | SIGNOR-266996 |
P00533 | Q05397 | 1 | phosphorylation | up-regulates | 0.595 | In this study, we demonstrate that growth factor receptors including hepatocyte growth factor receptor met, epidermal growth factor receptor, and platelet-derived growth factor receptor directly phosphorylate fak on tyr194 in the ferm domain collectively, this study provides the first example to explain how fak is act... | SIGNOR-167646 |
P49841 | Q13237 | 0 | phosphorylation | down-regulates activity | 0.258 | These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII. | SIGNOR-280095 |
Q96KN7 | Q92834 | 2 | binding | down-regulates activity | 0.714 | The RPGR H98Q and F130C mutants exhibit compromised interaction with RPGRIP1, suggesting that RPGR–RPGRIP1 interaction may be an important determinant of RPGR activity. As RPGRIP1 appears to link RPGR to the cilium, it is possible that RPGR's effect on RAB8A function may occur in distinct subcellular compartments of ph... | SIGNOR-253031 |
Q15398 | Q9Y3I1 | 2 | binding | down-regulates quantity by destabilization | 0.45 | We show here that Fbx7, an F-box protein without WD repeats and leucine-rich repeats, is required for the proteasome-mediated proteolysis of the hepatoma up-regulated protein (HURP).Thus, Fbx7 is a functional adaptor of the SCF complex with a proline-rich region as the substrate-binding module. Depletion of Fbx7 by sm... | SIGNOR-271506 |
P31749 | P62714 | 0 | dephosphorylation | down-regulates | 0.508 | These results confirm that the activity changes observed are achieved by a reversible phosphorylation mechanism, and also argue that pp2a may negatively regulate rac-pk activity in vivo. Dephosphorylation of the activated rac-pk in itro by pp2ac resulted in an 87% reduction of kinase activity | SIGNOR-252636 |
Q9H4P4 | O60260 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Here we further demonstrated that overexpression of Nrdp1 significantly reduced the endogenous Parkin level in an Nrdp1 dosage-dependent and proteasome-dependent manner. More importantly, Nrdp1 ubiquitinated Parkin and catalyzed the poly-ubiquitin chains on Parkin in vitro as well as in cells, indicating Parkin is an N... | SIGNOR-272639 |
P07437 | P84022 | 2 | binding | down-regulates activity | 0.2 | Smad2/3 also binds to _-tubulin, which provides a negative regulatory mechanism controlling tgf-_ activity. the results showed that the mh2 domain of smad2 binds to _-tubulin with almost the same efficiency as the full-length (wild-type) smad2. Similar results were obtained for the smad3 binding to _-tubulin. | SIGNOR-232113 |
P22888 | P10589 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.275 | Functional analysis showed that EAR2 and EAR3/COUP-TFI repressed the hLHR promoter activity, whereas TR4 activated hLHR gene transcription. | SIGNOR-266218 |
Q99500 | O95837 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257437 |
P78504 | O76050 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.707 | We find that NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation.|Jagged1 is also regulated by the E3 ligase Neuralized-like1 (Neurl1), which induces the monoubiquitination of membrane tethered Jagged1 in the C-terminal region. | SIGNOR-278772 |
P10275 | P11309 | 0 | phosphorylation | up-regulates activity | 0.381 | PIM1 phosphorylates the AR and 14-3-3 ζ and coordinates their interaction. PIM1 phosphorylation of the AR and 14-3-3 ζ enhances their interaction and shifts their occupancy on chromatin, resulting in 14-3-3 ζ co-regulation of AR, likely by recruiting other AR co-regulators such as hnRNPK and TRIM28. | SIGNOR-277575 |
P16949 | Q13554 | 0 | phosphorylation | down-regulates | 0.515 | Stimulation via cd2 activated multiple signal transduction pathways, resulting in phosphorylation of distinct sites of stathmin. Ser16 of recombinant human stathmin was phosphorylated also by purified cam kinase ii, and in vivo, cam kinase ii activity was indeed stimulated in cd2-triggered jurkat cells. | SIGNOR-59358 |
Q01860 | P26358 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.437 | Oct4 and Nanog upregulate Dnmt1 through direct binding to its promoter, thereby leading to the repressed expression of p16 and p21 and genes associated with development and lineage differentiation | SIGNOR-253158 |
P12259 | P08246 | 0 | cleavage | up-regulates activity | 0.366 | Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V|NH2-terminal sequence analysis of F.V treated with HNE indicated cleavage at Ile819 and Ile1484 under conditions during which the procofactor expressed enhanced cofactor activity in the prothrombinase complex. | SIGNOR-263637 |
Q15418 | P49841 | 1 | phosphorylation | down-regulates | 0.359 | S6k then phosphorylates the same serine residue on gsk3 that is targeted by pkb/akt (fig. 1), thereby inhibiting its activity. | SIGNOR-110917 |
P29350 | Q8NER1 | 1 | dephosphorylation | down-regulates activity | 0.2 | Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.|These results suggested that Shp-1 dephosphorylated and inhibited TRPV1 in DRG neurons, contributing to maintain thermal nociceptive thresholds in normal rats, and as a compensatory mechanism, Shp-1 increa... | SIGNOR-277129 |
P15259 | Q8IXJ6 | 0 | deacetylation | up-regulates activity | 0.2 | Here we report that PGAM is acetylated at lysine 100 (K100), an active site residue that is invariably conserved from bacteria, to yeast, plant, and mammals. K100 acetylation is detected in fly, mouse, and human cells and in multiple tissues and decreases PGAM2 activity. The cytosolic protein deacetylase sirtuin 2 (SIR... | SIGNOR-266518 |
P12272 | P07288 | 0 | cleavage | down-regulates activity | 0.422 | Our study demonstrates that PTHrP is a substrate for PSA. The cleavage of the amino-terminal portion of PTHrP completely disrupts its ability to interact with the PTH/PTHrP receptor and thus inhibits its PTH-like activity. | Our data show that PSA proteolytically cleaves PTHrP (1-34) after either residue 22 or 23, gene... | SIGNOR-270547 |
P21462 | P04083 | 2 | binding | up-regulates activity | 0.743 | We show that the mimetic N-terminal annexin 1 peptide Ac1-25 is able to activate and desensitize not only FPR but also FPRL1 and FPRL2. | SIGNOR-259439 |
Q92934 | P27361 | 0 | phosphorylation | down-regulates | 0.483 | Erk-1 map kinase prevents tnf-induced apoptosis through bad phosphorylation and inhibition of bax translocation in hela cells. | SIGNOR-188172 |
O15117 | P06241 | 0 | phosphorylation | up-regulates activity | 0.2 | two tyrosines, Tyr595 and Tyr651, of FYB are major sites of phosphorylation by FYN-T and mediate binding to SLP-76 in Jurkat T cells. We further demonstrate that the loss of SLP-76 binding by mutation of these sites markedly reduced the ability of FYN-T-FYB-SLP-76 to up-regulate IL-2 transcription. | SIGNOR-251163 |
P27448 | P30307 | 1 | phosphorylation | down-regulates activity | 0.485 | C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Phosphorylation of serine 21 6 promotes 1 4-3-3 binding to Cdc25C and is inhibitory to Cdc25C function. | SIGNOR-250176 |
P04637 | P02511 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.47 | Aberrant expression of CRYAB has been shown to be associated with several neurological diseases and malignant neoplasms. To identify transcriptional regulators of CRYAB expression, we examined its promoter for binding sites of transcription factors and identified four potential AP-2 binding sites in addition to a p53 b... | SIGNOR-253638 |
Q9NZ94 | Q9Y4C0 | 2 | binding | up-regulates activity | 0.825 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264162 |
Q9UHC7 | P38936 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.313 | Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21. In normal conditions, MKRN1 could destabilize both p53 and p21 through ubiquitination and proteasome-dependent degradation. A... | SIGNOR-271845 |
P15173 | P15172 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.46 | We conclude that MyoD is the major MRF that binds to the E-box from the myogenin promoter during differentiation. | SIGNOR-255640 |
P63096 | P21728 | 2 | binding | up-regulates activity | 0.284 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257068 |
P62834 | Q8WZA2 | 2 | binding | up-regulates quantity | 0.794 | The SUR1 subunit of KATP channels recruits Epac2 to the plasma membrane where a signaling complex comprised of Epac2, Rap1 and PLC-ε is formed. Rap1 is activated by Epac2, and the activated form of Rap1 binds to and activates PLC-ε. | SIGNOR-278143 |
Q07954 | P17252 | 0 | phosphorylation | up-regulates | 0.2 | Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase calpha regulates endocytosis and association with adaptor moleculesthese results indicate that elimination of serine and threonine phosphorylation sites in the lrp cytoplasmic domain reduces the extent of tyr6... | SIGNOR-127215 |
P12830 | Q5XUX0 | 2 | binding | down-regulates quantity by destabilization | 0.2 | Here we show that the low levels of FBXO31 are maintained through proteasomal degradation by anaphase-promoting complex/cyclosome (APC/C). We find that the APC/C coactivators CDH1 and CDC20 bind to a destruction-box (D-box) motif present in FBXO31 to promote its polyubiquitination and degradation in a cell-cycle-regula... | SIGNOR-277377 |
P06493 | Q03060 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.296 | The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41). A mutant form of ICER in which Ser-41 was substituted by alanine had a half-life 4-5 h longer than its wild-type counterpart. This alteration in stabili... | SIGNOR-275979 |
P35869 | Q16678 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.489 | The formation of the AHR/ARNT dimerization complex converts the AHR into a high affinity DNA-binding form that recognizes specific DNA recognition sites termed DREs. In this manner, the agonist activated AHR upregulates a battery of target genes, including those involved in the metabolism of chemical carcinogens, such ... | SIGNOR-253642 |
P49841 | Q13485 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.398 | In the presence of FGF, Wnt potentiates TGF-β signaling by preventing Smad4 GSK3 phosphorylations that inhibit a transcriptional activation domain located in the linker region. | SIGNOR-276440 |
P22736 | Q15349 | 0 | phosphorylation | down-regulates activity | 0.367 | Phosphorylation of a residue in the DNA-binding region (Ser-350 of NGFI-B and 354 of Nur77) has been described in detail to have effect on the transcriptional function of the protein [11, 24]. Growth-related kinase pp90rsk, but not ERK1 (pp44mapk), was shown to phosphorylate recombinant Nur77 in vitro in the DNA bindin... | SIGNOR-249429 |
P46531 | Q9ULJ6 | 2 | binding | up-regulates activity | 0.452 | The N-terminal domain (NTD) is critical for Zmiz1 to function as a Notch collaborator. Zmiz1 and Notch1 cooperatively recruit each other to chromatin through the TPR domain. The N-terminal domain (NTD) of Zmiz1 is important for enhancing Notch reporter activity and contains tetratricopeptide repeats (TPR) that mediate ... | SIGNOR-263937 |
O15297 | Q07812 | 1 | dephosphorylation | down-regulates activity | 0.2 | 34 In this study, a novel function of Wip1 was identified, that is, its ability to dephosphorylate directly and thus inactivate apoptotic BAX protein in response to gamma irradiation.|To ascertain whether Wip1 dephosphorylates BAX, recombinant Wip1 was incubated with previously reported BAX-derived phosphopeptides cont... | SIGNOR-276993 |
Q8IWW6 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.546 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260469 |
O60674 | P10912 | 1 | phosphorylation | up-regulates activity | 0.766 | Jak2 is then phosphorylated and, in turn, phosphorylates the GHR and the signal transducers and activators of transcription (STAT) protein. | SIGNOR-279198 |
Q12778 | Q13237 | 0 | phosphorylation | up-regulates activity | 0.356 | Biochemical assays using mammalian cGKII and FoxO1 reveal that cGKII enhances the transcriptional activity of FoxO1 through phosphorylation of the FoxO1 S319 site in the same manner as LRRK2. | SIGNOR-279564 |
O95837 | P08908 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257197 |
Q9UMX1 | P10070 | 1 | relocalization | down-regulates activity | 0.909 | We demonstrate here that Su(fu) prevents the nuclear accumulation of Gli1 and Gli2 through multiple mechanisms | SIGNOR-129065 |
O96013 | Q15796 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.339 | In addition, PAK4 phosphorylates Smad2 on Ser465, leading to the degradation of Smad2 through ubiquitin-proteasome-dependent pathway under hepatocyte growth factor (HGF) stimulation. | SIGNOR-279084 |
O60674 | P00519 | 0 | phosphorylation | up-regulates activity | 0.41 | Jak2 peptide substrate studies indicated that the Bcr-Abl and Abl tyrosine kinases specifically phosphorylated Y1007 of Jak2 but only poorly phosphorylated Y1008. Phosphorylation of Y1007 of Jak2 is known to be critical for its tyrosine kinase activation. | SIGNOR-245365 |
P04637 | Q9HCM9 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.351 | Furthermore, we show here that the Trim39 can directly bind and ubiquitylate p53 in vitro and in vivo, leading to p53 degradation. | SIGNOR-272020 |
P08069 | Q9Y4H2 | 1 | phosphorylation | up-regulates | 0.802 | Our results reveal that igf-1 receptors promote beta-cell development and survival through the irs-2 signalling pathway. | SIGNOR-70477 |
P49715 | P35247 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.259 | Cotransfection of C/EBPalpha, C/EBPbeta, or C/EBPdelta cDNA in H441 lung adenocarcinoma cells significantly increased the luciferase activity of a wild-type SP-D promoter construct containing 698 bp of upstream sequence (SS698). Transfection of C/EBP also increased the level of endogenous SP-D mRNA in H441 cells| Thus,... | SIGNOR-254042 |
P00519 | P22681 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.614 | We found that while c-cbl e3 ligase induced ubiquitin-dependent degradation of mature and phosphorylated bcr-abl proteins | SIGNOR-167194 |
Q16816 | P46020 | 2 | binding | down-regulates activity | 0.691 | Phk is among the most complex of the protein kinases so far elucidated. It has one catalytic (gamma) subunit and three different regulatory (alpha, beta, and delta) subunits, a molecular mass of 1.3 X 106 daltons, and each holoenzyme molecule is presumed to contain four molecules of each subunit. The three regulatory s... | SIGNOR-267405 |
P07339 | P02818 | 1 | cleavage | down-regulates quantity by destabilization | 0.314 | This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves o... | SIGNOR-256319 |
O95863 | Q16512 | 0 | phosphorylation | up-regulates | 0.2 | Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functionswe found for the first time that pak1 promotes transcription repression activity of snail from e-cadherin, occludin, and aromatase promoters. Pak1 regulates the repressor act... | SIGNOR-135609 |
O14920 | Q9Y5X2 | 2 | binding | up-regulates activity | 0.2 | IFNγ induced JAK1-mediated phosphorylation of SNX8 at Tyr95 and Tyr126, which promoted the recruitment of IKKβ to the JAK1 complex. | SIGNOR-273646 |
O14974 | O60285 | 0 | phosphorylation | down-regulates | 0.507 | Phosphorylation of ser(445), ser(472), and ser(910) of mypt1 by nuak1 promoted the interaction of mypt1 with 14-3-3 adaptor proteins, thereby suppressing phosphatase activity. | SIGNOR-164747 |
P00519 | P15056 | 0 | phosphorylation | up-regulates activity | 0.275 | BRAF V600E activates Abl and Arg.|Rather, BRAF V600E, a serine threonine kinase, induced Abl threonine phosphorylation (XREF_FIG), and tyrosine phosphorylation of kinase-inactive Abl or Arg, which lack the ability to autophosphorylate (XREF_FIG). | SIGNOR-278914 |
Q16659 | Q9Y6Q9 | 1 | phosphorylation | up-regulates | 0.481 | Here, we report that erk3 interacted with and phosphorylated steroid receptor coactivator 3 (src-3), an oncogenic protein overexpressed in multiple human cancers at serine 857 (s857) | SIGNOR-196957 |
P63092 | P29274 | 2 | binding | up-regulates activity | 0.3 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256766 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.