IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9UBU9 | Q16629 | 2 | binding | up-regulates | 0.669 | 9g8 and srp20 also enhance the tap rna-binding activity | SIGNOR-161338 |
Q14493 | Q96KK5 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265402 |
P38405 | P30550 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256917 |
Q96A56 | P60520 | 2 | binding | up-regulates | 0.38 | In this work, we show that tp53inp1 is also able to interact with atg8-family proteins and to induce autophagy-dependent cell death. mammalian cells contain multiple atg8 orthologs belonging to three subfamilies: microtubule-associated protein 1 light chain 3, -aminobutyric acid receptor-associated protein (gabarap) a... | SIGNOR-196667 |
P15735 | P11217 | 1 | phosphorylation | up-regulates activity | 0.55 | It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15 | SIGNOR-267400 |
P46934 | P60321 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | We find that NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation.|To examine whether complex formation of NEDD4 and NDFIP2 promotes NANOS2 ubiquitination in vivo, FLAG tagged NANOS2 was expressed in HEK293 cells with or without MYC-NEDD4 and MYC-NDFIP2. | SIGNOR-278770 |
O43464 | Q07812 | 0 | relocalization | up-regulates | 0.313 | Bax and/or bak-mediated release of pro-apoptotic mediators including smac/diablo and omi | SIGNOR-88590 |
O15146 | Q18PE1 | 2 | phosphorylation | up-regulates activity | 0.721 | Here, we demonstrate that Dok-7 also functions downstream from MuSK, and we identify the proteins that are recruited to the C-terminal domain of Dok-7. We show that Agrin stimulates phosphorylation of two tyrosine residues in the C-terminal domain of Dok-7, which leads to recruitment of two adapter proteins: Crk and Cr... | SIGNOR-273845 |
P19438 | P01375 | 2 | binding | up-regulates activity | 0.925 | For TNFR1, the cytokine TNFα binds to the receptor and triggers its trimerization, which leads to the assembly of the receptor complex and initiation of signaling. | SIGNOR-199091 |
O43395 | P51608 | 2 | binding | up-regulates activity | 0.267 | MeCP2 interacts directly with Prpf3 and Sdccag1|Notably, Mecp2308/Y mice, which produce a truncated form of MeCP2 and reproduce many of the classical features of RTT [43], have been shown to have multiple genes that are abnormally spliced in the brain [23]. This suggests the C-terminal portion of MeCP2, which we have i... | SIGNOR-277691 |
P31749 | P23396 | 1 | phosphorylation | up-regulates activity | 0.368 | Here, we show that human RPS3 is a physiological target of Akt kinase and a novel mediator of neuronal apoptosis. NGF stimulation resulted in phosphorylation of threonine 70 of RPS3 by Akt, and this phosphorylation was required for Akt binding to RPS3.our experiment demonstrated that Akt up-regulates the endonuclease a... | SIGNOR-259815 |
Q9UIF8 | P84243 | 2 | binding | down-regulates activity | 0.2 | The BAZ2B bromodomain has been shown to bind to acetylated H3K14 (H3K14ac), whose presence at promoter regions is generally associated with gene activation. This suggests a potential role for BAZ2B in transcriptional activation. | SIGNOR-266619 |
Q969F8 | P50148 | 2 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256750 |
P33032 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257271 |
Q9NXW2 | P11142 | 2 | binding | up-regulates activity | 0.509 | JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTRΔF508 for degradation. JB12 drives Hsc70 to associate with CFTR and the RMA1 E3 complex | SIGNOR-271491 |
P12931 | P08238 | 1 | phosphorylation | up-regulates | 0.587 | C-src directly phosphorylates hsp90 on tyrosine 300 residue and that this event is essential for vegf-stimulated enos association to hsp90 and thus no release from endothelial cells. | SIGNOR-157781 |
Q7Z6I6 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.403 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260486 |
Q15418 | Q9UBP6 | 1 | phosphorylation | down-regulates | 0.324 | Pkb and ribosomal s6 kinase (rsk) both phosphorylated mettl1 at ser27 in vitro. | SIGNOR-135948 |
Q9P1A6 | Q9BYB0 | 1 | relocalization | up-regulates activity | 0.2 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264591 |
O14920 | P25963 | 1 | phosphorylation | down-regulates activity | 0.922 | Tak1 become activated and then phosphorilates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation | SIGNOR-235400 |
P02545 | P06493 | 0 | phosphorylation | up-regulates | 0.536 | Phosphorylation by mitotic cdc2 kinase at ser-22, ser-390, and ser-392 residues on lamin a/c, or by protein kinase c (pkc) during apoptosis, leads to the depolymerization of lamin (disassembly of the nuclear lamina), which may lead to their release from the inm | SIGNOR-181314 |
Q02779 | Q7Z6J0 | 2 | binding | up-regulates | 0.355 | Taken together, these findings support a model in which apoptotic stimuli or posh overexpression induce direct association between posh and inactive mlks. | SIGNOR-97003 |
P31751 | P18031 | 1 | phosphorylation | down-regulates activity | 0.372 | We conclude that ptp1b is a novel substrate for akt and that phosphorylation of ptp1b by akt at ser(50) may negatively modulate its phosphatase activity creating a positive feedback mechanism forinsulin signaling | SIGNOR-235491 |
Q9H992 | Q15051 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH7 induces K48 ubiquitination of NPHP5 and protein degradation, while BBS11 triggers K63 ubiquitination and protein delocalization.|Unlike the catalytically inactive mutant , wild type MARCH7 was able to trigger NPHP5 ubiquitination (XREF_FIG). | SIGNOR-278585 |
Q9UQE7 | Q05195 | 2 | binding | down-regulates activity | 0.296 | We identified a novel ZIP-containing protein, Mmip1 (Mad member interacting protein 1) that strongly dimerizes with all four Mad members, but not with c-myc. Mmip1 can inhibit DNA binding by Max-Mad heterodimers and, in vivo, can reverse the suppressive eects of Mad proteins on c-myc functions. | SIGNOR-241278 |
Q13362 | P67775 | 2 | binding | up-regulates activity | 0.864 | We have identified by two-hybrid interaction a new human gene family encoding PP2A B subunits. This family, denoted B56, contains three distinct genes, one of which is differentially spliced. | SIGNOR-268155 |
Q13253 | P18075 | 2 | binding | down-regulates activity | 0.852 | We report the crystal structure of the antagonist Noggin bound to BMP-7, which shows that Noggin inhibits BMP signalling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. | SIGNOR-256484 |
P47712 | Q05513 | 0 | phosphorylation | up-regulates activity | 0.327 | To further evaluate cPLA2 as a candidate substrate for PKCζ, we developed a custom antibody recognizing the cPLA2 T376 phosphorylation site. Specificity was validated in both serum starved/stimulated samples | SIGNOR-277518 |
P03372 | Q13888 | 0 | phosphorylation | up-regulates activity | 0.257 | TFIIH Phosphorylates Human Estrogen Receptor α at Serine 118 | We report here that Cdk7 overexpression stimulates transcription activation by ERα by stimulating phosphorylation of S118 in a ligand-dependent manner. | SIGNOR-260817 |
Q15300 | P40763 | 1 | phosphorylation | up-regulates activity | 0.2 | In addition, RET/PTC-mediated cellular transformation and proliferation of transformed cells require tyrosine 705 phosphorylation of STAT3 in NIH3T3 cells. We conclude that STAT3 activation by the RET/PTC tyrosine kinase is one of the critical signaling pathways for the regulation of specific genes, such as cyclin D1, ... | SIGNOR-260917 |
P40763 | P28482 | 0 | phosphorylation | down-regulates activity | 0.75 | ERK2 phosphorylates Stat3 on three serine-containing peptides and decreases its tyrosine phosphorylation induced by EGF treatment.|Here, we report that ERK2 activated by its upstream kinase, MEK1, represses Stat3 transcriptional activity induced by Src or Jak-2. | SIGNOR-279635 |
P24844 | Q15746 | 0 | phosphorylation | up-regulates | 0.838 | More than a dozen kinases have been reported to phosphorylate the rlcs of nm ii (fig. 2), including myosin light chain kinase (mlck;also known as mylk), rho-associated, coiled coil-containing kinase (rock), citron kinase, leucine zipper interacting kinase (zipk;also known as dapk3) and myotonic dystrophy kinase-related... | SIGNOR-188797 |
P28329 | Q13555 | 0 | phosphorylation | up-regulates activity | 0.307 | Using mass spectrometry, we identified threonine 456 as a new phosphorylation site in choline acetyltransferase from A beta-(1-42)-treated cells and in purified recombinant ChAT phosphorylated in vitro by calcium/calmodulin-dependent protein kinase II (CaM kinase II). | This phosphorylation combination was observed in ... | SIGNOR-250693 |
O00401 | P16333 | 2 | binding | up-regulates | 0.78 | Nck and cdc42 activate n-wasp by redundant mechanisms. | SIGNOR-107634 |
O43613 | O95837 | 2 | binding | up-regulates activity | 0.435 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257294 |
Q96KB5 | Q13547 | 1 | phosphorylation | up-regulates activity | 0.245 | TOPK overexpression promotes HDAC1 and HDAC2 phosphorylation and Histone 3 and Histone 4 acetylation in BV2 cells.|The results of in vitro studies further confirmed the effect of TOPK on HDAC activity by showing that TOPK overexpression significantly up-regulated p-HDAC1 and p-HDAC2, resulting in an increase in the ace... | SIGNOR-279086 |
P98155 | P02649 | 2 | binding | up-regulates | 0.635 | Several ligands for the vldl receptor have been identified in addition to tfpi. These include apolipoprotein e (apoe) | SIGNOR-106221 |
Q13951 | Q01196 | 2 | binding | up-regulates quantity by stabilization | 0.848 | The RUNX genes encode the α subunit of the transcription factor PEBP2/CBF. The β subunit consists of the non-RUNX protein PEBP2β. We found that RUNX1/AML1, which is essential for hematopoiesis, is continuously subjected to proteolytic degradation mediated by the ubiquitin–proteasome pathway. When PEBP2β is present, how... | SIGNOR-255742 |
P08754 | Q9NPC1 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256817 |
Q9UHF4 | P23458 | 2 | binding | up-regulates | 0.486 | Each r1-type chain (il-10r1, il-20r1, il-22r1, ifn-_r1 and ifn-_r1) is associated with jak1 tyrosine kinase and mediates recruitment of a variety of signaling molecules after being phosphorylated on its intracellular domain. | SIGNOR-124486 |
P01579 | P38484 | 2 | binding | up-regulates | 0.649 | Ifn-g Binds to the ifn-g Receptor binding subunit (ifn-gR1;receptor chain 1), a species-specific cell surface transmembrane receptor chain (41, 42). A second transmembrane protein (ifn-gR2) (43 45) is required for signal transduction | SIGNOR-31013 |
Q969J5 | Q9GZX6 | 2 | binding | up-regulates | 0.746 | Il-22 mediates inflammation and binds class ii cytokine receptor heterodimers il-22 ra1/crf2-4. | SIGNOR-86113 |
Q96JJ3 | P63000 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.583 | We found in this study that AUTS2 is involved in Rac1 activation via P-Rex1 and the Elmo2/Dock180 complex, but not STEF or Tiam1, for the lamellipodia formation in N1E-115 cells. However, the enhancement of neurite elongation in primary neurons by AUTS2 expression is specifically mediated by the Elmo2/Dock180 complex. ... | SIGNOR-266821 |
Q15375 | O43921 | 2 | binding | up-regulates | 0.806 | The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. | SIGNOR-52206 |
P28482 | P19419 | 1 | phosphorylation | up-regulates activity | 0.563 | We demonstrate that elk-1, a protein closely related to p62tcf in function, is a nuclear target of two members of the map kinase family, erk1 and erk2, erk1 phosphorylates five c-terminal sites in elk-1 (s324,t336, s383, s389 and s422) with varying degrees of efficiency. | SIGNOR-235455 |
Q99558 | P41279 | 0 | phosphorylation | up-regulates activity | 0.559 | In studies of NIK, we found that Thr-559 located within the activation loop of its kinase domain regulates NIK action. Alanine substitution of Thr-559 but not other serine or threonine residues within the activation loop abolishes its activity and its ability to phosphorylate and activate IKKalpha | SIGNOR-249387 |
Q8TDY4 | Q15052 | 2 | binding | up-regulates activity | 0.294 | ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 4 (ACAP4) is an ADP-ribosylation factor 6 (ARF6) GTPase-activating protein essential for EGF-elicited cell migration. |The crystal structure of the catalytic core of ACAP4 in a complex with ARF6 reveals the structural determinants underlying ACAP4 selectivity and s... | SIGNOR-272235 |
O00750 | P14373 | 0 | ubiquitination | down-regulates | 0.402 | We now show that trim27 functions as an e3 ligase and mediates lysine 48 polyubiquitination of pi3kc2_, leading to a decrease in pi3k enzyme activity. | SIGNOR-177935 |
P63151 | Q96E09 | 2 | binding | down-regulates activity | 0.2 | We demonstrate that the highly conserved protein in mammals, designated FAM122A, directly interacts with PP2A-Aα and B55α rather than B56α subunits, and inhibits the phosphatase activity of PP2A-Aα/B55α/Cα complex. | SIGNOR-266379 |
O95147 | Q15750 | 1 | dephosphorylation | down-regulates activity | 0.298 | DUSP14 directly interacted with TGF-beta-activated kinase 1 (TAK1)-binding protein 1 (TAB1) and dephosphorylated TAB1 at Ser (438), leading to TAB1 and TAK1 complex inactivation in T cells. | SIGNOR-277147 |
Q9H461 | O75581 | 2 | binding | up-regulates activity | 0.755 | Ligands such as Wnt1, Wnt3a, and Wnt8 couple the seven-transmembrane domain receptor Frizzled (Fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (LRP5/6) to activate WntBeta-catenin signaling. | SIGNOR-169638 |
P01178 | Q6IMN6 | 0 | post transcriptional regulation | up-regulates quantity by stabilization | 0.2 | Transcriptional and post-transcriptional regulation of oxytocin and vasopressin gene expression by CREB3L1 and CAPRIN2|Altogether, the data indicate that CAPRIN2 binds Oxt mRNA |Therefore, we propose that CAPRIN2 facilitates post-transcriptional modifications that increase Oxt transcript stability. | SIGNOR-268556 |
Q15831 | P46937 | 1 | phosphorylation | down-regulates activity | 0.305 | LKB1 induces phosphorylation of Yap, leading to Yap nuclear exclusion and ultimately its degradation.|These data indicated that LKB1 expression inhibits Yes-associated protein transcriptional function. | SIGNOR-280139 |
Q13470 | P27448 | 0 | phosphorylation | down-regulates activity | 0.2 | We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14... | SIGNOR-273868 |
Q96G30 | P33032 | 2 | binding | down-regulates activity | 0.502 | We report that MRAP and MRAP2 can interact with all 5 MCRs. This interaction results in MC2R surface expression and signaling. In contrast, MRAP and MRAP2 can reduce MC1R, MC3R, MC4R, and MC5R responsiveness to [Nle4,D-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH). MRAP and MRAP2 can reduce the surface expression... | SIGNOR-252369 |
P24386 | P53611 | 2 | binding | down-regulates activity | 0.768 | Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this compl... | SIGNOR-265571 |
P10636 | P07384 | 0 | cleavage | down-regulates activity | 0.333 | Besides tau phosphorylation, calpain activation might play a role in tau-mediated neurodegeneration by inducing tau cleavage. In vitro studies have shown that both fetal and adult tau isoforms are rapidly proteolyzed by calpains | SIGNOR-251584 |
O75581 | Q5JTC6 | 2 | binding | up-regulates activity | 0.478 | Knockdown of Amer1 reduces Wnt-induced LRP6 phosphorylation, Axin translocation to the plasma membrane and formation of LRP6 signalosomesThe generation of PtdIns(4,5)P2 in regions of receptor activity triggers the recruitment of Amer1 proteins, which in turn promote LRP6 phosphorylation by recruiting Axin/GSK3_ and CK1... | SIGNOR-24265 |
Q8WY64 | P98155 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.698 | Here we demonstrate that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism. Idol triggers ubiquitination of the VLDLR and ApoER2 on their cytoplasmic tails, leading to their degradation. | SIGNOR-271487 |
O75460 | P07237 | 2 | binding | down-regulates activity | 0.427 | The secretory pathway kinase Fam20C phosphorylates Ser357 of PDI and responds rapidly to various ER stressors. Phosphorylation of Ser357 induces an open conformation of PDI and turns it from a "foldase" into a "holdase", which is critical for preventing protein misfolding in the ER. Phosphorylated PDI also binds to the... | SIGNOR-275573 |
Q2M2I8 | Q9BXS5 | 1 | phosphorylation | up-regulates | 0.2 | Aak1 is enriched at presynaptic terminals, whereas in nonneuronal cells it colocalizes with clathrin and ap2 in clathrin-coated pits and at the leading edge of migrating cells. Aak1 specifically phosphorylates the mu subunit in vitro, and stage-specific assays for endocytosis show that mu phosphorylation by aak1 result... | SIGNOR-115589 |
Q9H461 | O75197 | 2 | binding | up-regulates activity | 0.728 | Ligands such as Wnt1, Wnt3a, and Wnt8 couple the seven-transmembrane domain receptor Frizzled (Fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (LRP5/6) to activate WntBeta-catenin signaling. | SIGNOR-169635 |
Q9UPS6 | P84243 | 1 | methylation | down-regulates activity | 0.2 | SETD1B encodes a lysine-specific methyltransferase that assists in transcriptional activation of genes by depositing H3K4 methyl marks. | SIGNOR-265578 |
Q15139 | P24723 | 0 | phosphorylation | up-regulates | 0.355 | These results provide direct evidence that pkd becomes activated in vivo as a consequence of pkc-mediated phosphorylation of serines 744 and 748. | SIGNOR-66734 |
P28482 | P35236 | 2 | phosphorylation | up-regulates activity | 0.812 | First, Erk phosphorylates HePTP at residues Thr45 and Ser72. Second, HePTP dephosphorylates Erk at PTyr185.| | SIGNOR-249436 |
P41162 | Q9UHI6 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.739 | ETV3 target genes including etv3, ddx20, and dusp6 provide negative feedback regulation of ETV3 production and activity. Negative feedback along with constitutive instability may serve to tightly regulate ETV3 abundance. Our date suggest that phosphorylation by ERK2 relieves repression by ETV3, allowing activation of c... | SIGNOR-262779 |
Q8TDN4 | P24941 | 2 | binding | down-regulates activity | 0.494 | Our study also showed that Cables1 increases the level of p21 and decreases the level of pRb, but does not affect the other cell cycle-related proteins we studied. Induction of apoptosis by Cables1, which occurs partially through inhibiting Cdk2 activity and upregulating p21, is prevented by Akt phosphorylation and 14-... | SIGNOR-276759 |
O14672 | Q12926 | 0 | post transcriptional regulation | up-regulates quantity | 0.2 | Neuronal ELAV (nELAV) proteins are RNA-binding proteins which play a physiological role in controlling gene expression in memory formation, and their alteration may contribute to cognitive impairment associated with neurodegenerative pathologies such as Alzheimer's disease (AD). The experiments show for the first time ... | SIGNOR-266863 |
Q8IXL6 | Q96HE7 | 1 | phosphorylation | up-regulates activity | 0.2 | We further show that ER oxidoreductin 1α (Ero1α), the pivotal sulfhydryl oxidase that catalyzes disulfide formation in the ER, is phosphorylated by Fam20C in the Golgi apparatus and retrograde-transported to the ER mediated by ERp44. The phosphorylation of Ser145 greatly enhances Ero1α oxidase activity and is critical ... | SIGNOR-277395 |
P68431 | P29375 | 0 | demethylation | up-regulates activity | 0.2 | KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. | SIGNOR-264299 |
O43524 | Q16539 | 0 | phosphorylation | up-regulates | 0.521 | Ogether, our results suggest that p38 phosphorylation of foxo3a on ser-7 is essential for its nuclear relocalization in response to doxorubicin | SIGNOR-177927 |
Q8IW41 | P12931 | 0 | phosphorylation | up-regulates quantity | 0.372 | These data strongly suggest that PRAK phosphorylation by Src on Y188 and Y216 drives the relocalization of PRAK to focal adhesion structures during cell adhesion. | SIGNOR-279762 |
Q14493 | P0C1H6 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265395 |
P46940 | Q8IVH8 | 0 | phosphorylation | up-regulates activity | 0.2 | GLK directly phosphorylated IQGAP1 at Ser-480 enhancing Cdc42 activation and subsequent cell migration. | SIGNOR-277479 |
Q8IXJ6 | Q92831 | 2 | binding | down-regulates | 0.53 | Sir2 forms a complex with the acetyltransferase pcaf and myod and, when overexpressed, retards muscle differentiation. | SIGNOR-104248 |
Q9Y297 | P08151 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.664 | Here we show that Gli is rapidly destroyed by the proteasome and that mouse basal cell carcinoma induction correlates with Gli protein accumulation. We identify two independent destruction signals in Gli1, D(N) and D(C), and show that removal of these signals stabilizes Gli1 protein and rapidly accelerates tumor format... | SIGNOR-235631 |
Q92985 | P0C725 | 2 | binding | down-regulates activity | 0.2 | EBV LF2 tegument protein specifically interacts with the central inhibitory association domain of IRF7, and this interaction leads to inhibition of the dimerization of IRF7, which suppresses IFN-alpha production and IFN-mediated immunity. | SIGNOR-266632 |
P49768 | P55210 | 0 | cleavage | up-regulates activity | 0.342 | Remarkably, the caspases acting on PS1 could be subdivided in two groups. One group, containing caspase-8, -6 and -11, cleaved PS1 after residues ENDD329 and to a lesser extent after residues AQRD341. A second group consisting of caspase-3, -7 and -1 acted uniquely on AQRD341. Importantly, these two cleavage sites were... | SIGNOR-261757 |
P48736 | P10747 | 2 | binding | up-regulates | 0.368 | Cd28 can bind directly to pi3k by a well-characterized ymnm binding motif in its cytoplasmic domain. | SIGNOR-159322 |
Q6PHR2 | P53990 | 1 | phosphorylation | down-regulates activity | 0.624 | ULK3 phosphorylation of IST1 is required to sustain the abscission checkpoint and inhibits IST1 function in abscission. | SIGNOR-278205 |
Q9NPD5 | P20823 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.251 | Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.|This study demonstrated that the transcription of the LST-2 gene is regulated by three transcription factors, FXR, HNF1alpha, and HNF3beta. | SIGNOR-268988 |
P84243 | Q92831 | 0 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269620 |
P06400 | O15194 | 0 | dephosphorylation | up-regulates activity | 0.298 | ppRB (RB phosphorylated at Ser-807/811|Possible Mechanisms of HYA22 Action in Tumorigenesis: Dephosphorylation of RB by Transient Expression of HYA22 Isoforms. | SIGNOR-248304 |
Q9BZS1 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.285 | Our previous study showed, by mass spectrometry analysis, that GSK-3β phosphorylates Foxp3 at Ser270 and Ser275 | SIGNOR-277245 |
Q13547 | Q9H4L7 | 2 | binding | up-regulates activity | 0.319 | SMARCAD1 interacts with HDAC1 and KAP1 and is required for their binding to heterochromatin | SIGNOR-239835 |
P24522 | P06493 | 2 | binding | down-regulates | 0.71 | Gadd45 has now been found to directly inhibit the activity of cdc2/cyclin b1 complex | SIGNOR-68221 |
Q07343 | P28482 | 0 | phosphorylation | up-regulates activity | 0.268 | The short-form PDE4B2 isoenzyme was activated by Erk2 phosphorylation. These functional changes in PDE activity were mimicked by mutation of the target serine for Erk2 phosphorylation to the negatively charged amino acid, aspartic acid. | SIGNOR-275970 |
Q05655 | Q8TCJ0 | 1 | phosphorylation | up-regulates activity | 0.271 | FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex. An unbiased screen uncovered the prosurvival protein HCLS1-associated protein X-1 (HAX-1) as the bona fide substrate of FBXO25 that is targeted after apoptotic stresses. Protei... | SIGNOR-275561 |
P31749 | Q9H9Q4 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.358 | Akt1 phosphorylates XLF at T181 Here, we report that Akt phosphorylates XLF at Thr181 to trigger its dissociation from the DNA ligase IV/XRCC4 complex, and promotes its interaction with 14-3-3β leading to XLF cytoplasmic retention, where cytosolic XLF is subsequently degraded by SCF(β-TRCP) in a CKI-dependent manner. | SIGNOR-276881 |
P39900 | P00748 | 1 | cleavage | down-regulates quantity by destabilization | 0.33 | The data presented in this study show for the first time the degradation of Factor XII of the blood clotting system by matrix metalloproteinases. MMP-12, MMP-13, and MMP-14 cleave at Gly376Leu377|However, no activity of Factor XII can be observed after MMPinduced cleavage. | SIGNOR-263611 |
O15379 | Q6W2J9 | 2 | binding | up-regulates activity | 0.313 | BCoR can interact w Because HDACs appear to be involved in repression by an increasing number of transcriptional repressors, we tested whether BCoR can associate with HDACs. BCoR can interact with HDAC1, HDAC3, and HDAC-B/5 more strongly than with HDAC-A/4, HDAC-C, HDAC-D, and HDAC-E. | SIGNOR-252237 |
P43403 | Q9Y2R2 | 0 | dephosphorylation | down-regulates | 0.706 | Native ptpn22 dephosphorylated lck and zap70 at their activating tyrosine residues tyr-394 and tyr-493, respectively, but not at the regulatory tyrosines tyr-505 (lck) or tyr-319 (zap70). | SIGNOR-144345 |
Q9H0Y0 | O94817 | 2 | binding | up-regulates | 0.878 | Analogous to ubiquitination, atg12 is conjugated to atg5 by atg7--an e1-like protein--and atg10--an e2-like protein. | SIGNOR-180129 |
P23528 | Q96MS0 | 0 | post transcriptional regulation | up-regulates quantity by expression | 0.2 | Slit2 causes the miRNA miR-182 to release cofilin1 mRNA, potentiating cofilin1 local translation and resulting in growth cone collapse. The use of morpholinos or RNAi to knockdown robo2 and robo3 in X. laevis RGCs, would be useful to further confirm that Robo2 and Robo3 are the receptors involved in Slit2-dependent cof... | SIGNOR-268379 |
Q16625 | Q96J02 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.348 | Two mechanisms regarding junction protein turnover were illustrated in this process, that is, the Itch-induced occludin ubiquitination and proteasome degradation, and the caveolae-dependent endocytosis of junction proteins (JAM-A, N-cadherin, and \u03b2 -catenin), both of which led to the instability of junction appara... | SIGNOR-278756 |
Q9UHC7 | P11940 | 1 | ubiquitination | up-regulates activity | 0.35 | We show that MKRN1 directly binds to the cytoplasmic poly(A)-binding protein (PABPC1) and associates with polysomes. MKRN1 is positioned upstream of poly(A) tails in mRNAs in a PABPC1-dependent manner. Ubiquitin remnant profiling and in vitro ubiquitylation assays uncover PABPC1 and ribosomal protein RPS10 as direct ub... | SIGNOR-272215 |
O60609 | Q5T4W7 | 2 | binding | up-regulates | 0.762 | Here, we report the identification of artemin, a novel member of the gdnf family, and demonstrate that it is the ligand for the former orphan receptor gfralpha3-ret. Artemin can also activate the gfralpha1-ret complex. | SIGNOR-63009 |
Q13535 | P30307 | 1 | phosphorylation | up-regulates activity | 0.643 | We also found that activated ATR phosphorylates CDC25C (Cell Division Cycle 25C) at serine 216, which in turn inactivates the cyclin B1/Cyclin-Dependent Kinase 1(CDK1) complex and induces G2-phase arrest. | SIGNOR-279008 |
P01112 | P48736 | 2 | binding | up-regulates | 0.821 | Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85. it was also described that ras interacts with pi3k in a direct manner. lysine residue 227 is essential for the interaction of ras with pi3k we show here, however, that in vivo there are marked quantitative differenc... | SIGNOR-59816 |
Q9Y5F6 | Q9Y5H9 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265683 |
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