IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9UI09 | P06493 | 0 | phosphorylation | up-regulates activity | 0.2 | Here, we show that a fraction of cyclin B1/Cdk1 proteins localizes to the matrix of mitochondria and phosphorylates a cluster of mitochondrial proteins, including the complex I (CI) subunits in the respiratory chain. Cyclin B1/Cdk1-mediated CI phosphorylation enhances CI activity, whereas deficiency of such phosphoryla... | SIGNOR-275587 |
Q13233 | Q13153 | 0 | phosphorylation | up-regulates activity | 0.538 | We found that pak1 phosphorylated mekk1 on serine 67 of its amino-terminal regulatory domain. mekk1 activity was increased modestly following pak phosphorylation. | SIGNOR-236006 |
P15407 | P17535 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.817 | Members of the AP1 family distinctly regulated the fra-1 promoter. In particular, coexpression of c-Jun, Jun-D, and Fra-2 up-regulated fra-1 transcription. | SIGNOR-261603 |
O14965 | Q02224 | 1 | phosphorylation | down-regulates activity | 0.48 | Aurora A also phosphorylates and inhibits the centromere-associated kinesin CENP-E involved in efficient chromosome congression ( xref ; xref ). | SIGNOR-280187 |
Q9UNE7 | Q7Z2Y5 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Our results indicate that Nrk is ubiquitinated by CHIP in a chaperone-dependent manner, resulting in its proteasomal degradation. | SIGNOR-274110 |
Q15139 | Q14247 | 1 | phosphorylation | down-regulates | 0.421 | Pkd phosphorylates cortactin in vitro and in vivo at serine 298 thereby generating a 14-3-3 binding motif. In vitro, a phosphorylation-deficient cortactin-s298a protein accelerated vca-arp-cortactin-mediated synergistic actin polymerization and showed reduced f-actin binding | SIGNOR-164756 |
P12643 | P12643 | 2 | binding | up-regulates | 0.2 | Bmps are dimeric proteins with a single interchain disulfide bond. The dimeric conformation is an absolute requirement for the biological action and interaction with receptors | SIGNOR-236166 |
P04908 | Q86Y13 | 0 | monoubiquitination | up-regulates activity | 0.2 | 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TL... | SIGNOR-271747 |
Q9NZQ7 | Q8IZR5 | 0 | stabilization | up-regulates quantity by stabilization | 0.353 | Furthermore, the observations that (i) CMTM6 affects PD-L1 protein stability at late time points after biosynthesis; (ii) CMTM6, CMTM4 and PD-L1 interact, as shown by co-immunoprecipitation; and that (iii) CMTM6 is largely located at the cell surface, collectively suggest a model in which CMTM6 interacts with PD-L1 at ... | SIGNOR-274981 |
Q16665 | P01588 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.643 | Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) gene. | SIGNOR-253695 |
P06400 | P05771 | 0 | phosphorylation | down-regulates activity | 0.352 | The exact mechanism by which PKCbeta degrades RB is unknown.|To attribute increased RB phosphorylation specifically to PKC\u03b2, we transiently transfected PKC\u03b2 -/- hepatocytes, and reintroduction of PKC\u03b2 specifically resulted in increased in phospho-RB (Ser780) levels, further supporting that PKC\u03b2 phos... | SIGNOR-280083 |
O43524 | Q13627 | 0 | phosphorylation | down-regulates | 0.359 | Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity phosphorylation of foxos by akt, ikk, erk, ck1, cdk2, and dyrk1a universally leads to foxo's inhibition. | SIGNOR-183674 |
Q92615 | P11940 | 2 | binding | up-regulates activity | 0.556 | Here we show that LARP4B is a cytoplasmic protein that co-sediments with polysomes and accumulates upon stress induction in stress granules. Biochemical studies further show that the protein interacts with two key factors of the translational machinery, namely, the cytoplasmic poly(A) binding protein (PABPC1) and the r... | SIGNOR-260940 |
O75581 | Q6IMN6 | 2 | binding | up-regulates | 0.358 | A cytoplasmic protein in vertebrates, referred to as caprin-2, binds to lrp6 and facilitates lrp6 phosphorylation by gsk3 | SIGNOR-187177 |
P48200 | P06493 | 0 | phosphorylation | down-regulates | 0.353 | Irp2 ser-157 is phosphorylated by cdk1/cyclin b1 during g(2)/m / ser-157 phosphorylation during g(2)/m reduces irp2 rna-binding activity | SIGNOR-179171 |
O95835 | Q96J02 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.516 | Furthermore, ITCH mediated degradation of LATS1 was associated with enhanced cell growth, induction of epithelial-mesenchymal transition, and increased tumorigenicity.|Ubiquitination of LATS1 catalyzed by ITCH stimulated the proteasomal degradation of LATS1. | SIGNOR-278816 |
P78527 | P16104 | 1 | phosphorylation | up-regulates | 0.2 | Dna-dependentprotein_ kinase_ (dna-pk) that phosphorylate h2ax at dsbs | SIGNOR-192443 |
P15153 | Q7Z6J0 | 2 | binding | up-regulates | 0.263 | Posh interacts with the gtp form of rac but not the gdp form | SIGNOR-55811 |
P01116 | Q13233 | 2 | binding | up-regulates | 0.366 | Mitogen-activated protein kinase kinase kinase (mekk1) is a serine-threonine kinase that regulates sequential protein kinase pathways involving stress-activated protein kinases and mitogen-activated protein kinases. Mekk1 is activated in response to growth factor stimulation of cells and by expression of activated ras.... | SIGNOR-32620 |
P53350 | O94901 | 1 | phosphorylation | down-regulates activity | 0.453 | Here, we show that SUN1, located in the INM, undergoes mitosis-specific phosphorylation on at least 3 sites within its nucleoplasmic N-terminus. We further identify Cdk1 as the kinase responsible for serine 48 and 333 phosphorylation, while serine 138 is phosphorylated by Plk1. Together, these data support a model wher... | SIGNOR-263098 |
Q13315 | Q12888 | 1 | phosphorylation | up-regulates | 0.873 | Here we report phosphorylation of 53bp1 at several novel residues, using mass spectrometry and phospho-specific antibodies, and show that ionising radiation-stimulated phosphorylation of these residues requires atm. | SIGNOR-197615 |
Q13043 | O43524 | 1 | phosphorylation | up-regulates | 0.681 | Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. | SIGNOR-178190 |
P17612 | Q92736 | 1 | phosphorylation | up-regulates activity | 0.478 | PKA-mediated hyperphosphorylation of a conserved serine, Ser-2843 in skeletal RyR and Ser-2809 in cardiac RyR, results in an aberrant SR function during heart failure. hyperphosphorylated RyRs are leaky and therefore lead to a reduced SR Ca2+ load and impaired contractile function in heart failure | SIGNOR-250079 |
Q9NQR1 | Q9UNH5 | 0 | dephosphorylation | down-regulates quantity by destabilization | 0.2 | The dephosphorylation of S29 during late mitosis by the Cdc14 phosphatases was required for APC(cdh1)-mediated ubiquitination of PR-Set7 and subsequent proteolysis. | SIGNOR-248835 |
Q13485 | P53350 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.254 | We observed that PLK1 could significantly promote the ubiquitination and degradation of Smad4 wild type, Smad4 S171A, Smad4 S187A, Smad4 S191A, respectively, but PLK1-induced the ubiquitination and degradation of Smad4 T197A were obviously inhibited (Fig. 1M). | SIGNOR-277591 |
Q96M91 | Q96DT5 | 2 | binding | up-regulates activity | 0.2 | CFAP53 likely facilitates the transport of TTC25 and the dyneins into cilia. CFAP53 at the centriolar satellites may form a complex with TTC25 and ODAs, including DNAH5 and DNAH11, and regulate their trafficking into the cilium (Fig 10B). | SIGNOR-265545 |
P01903 | Q12986 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.396 | A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor | SIGNOR-266224 |
Q9UNE7 | Q5S007 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.433 | CHIP can ubiquitinate LRRK2.|These results indicate that both the chaperone interaction and the ubiquitin ligase activity of CHIP are required for CHIP mediated degradation of LRRK2 protein. | SIGNOR-278615 |
Q00535 | Q00536 | 1 | phosphorylation | up-regulates activity | 0.335 | Taken together, our findings demonstrate that Pctaire1 interacts with p35, both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 enhances its kinase activity. | SIGNOR-279149 |
P60953 | A1L390 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.354 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260585 |
O95180 | P51170 | 2 | binding | up-regulates activity | 0.2 | This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β- and γ-ENaC subunits could be co-immunoprecipitated with Cav3.2 calcium channels from brain lysates, dorsal horn and lumbar dorsal root ganglia. Αβγ-ENaC channels enhanced Cav3.2 calcium channel ... | SIGNOR-269274 |
P38405 | P25105 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256932 |
Q8N884 | P43405 | 0 | phosphorylation | up-regulates activity | 0.2 | Mechanistically, viral infection or foreign DNA transfection triggers recruitment of the spleen tyrosine kinase (SYK) and cGAS to the endosomal vacuolar H+ pump (V-ATPase), where SYK is activated and then phosphorylates human cGASY214/215 (mouse cGasY200/201) to prime its activation. | SIGNOR-277844 |
P04150 | P41235 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.37 | Electrophoretic mobility shift, chromatin immunoprecipitation (ChIP), and streptavidin DNA binding assays revealed that DEX increased binding of HNF4alpha to the HNF4-RE and that an interaction of GR and HNF4alpha occurred at this site. | SIGNOR-251684 |
O43504 | Q14765 | 2 | binding | up-regulates activity | 0.327 | It suggests that HBXIP is able to activate S100A4 promoter via interacting with STAT4 in breast cancer cells, leading to the up-regulation of S100A4. here we first report that the transcription factor STAT4 plays a role in regulating S100A4 mediated by HBXIP in breast cancer. | SIGNOR-255247 |
P19086 | Q96P68 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257310 |
P30989 | P50148 | 2 | binding | up-regulates activity | 0.471 | Altogether, these results reveal for the first time the ability of hNTS1 to directly activate the Gαq-, Gαi1-, GαoA-, and Gα13-mediated signaling pathways | SIGNOR-278058 |
P49841 | O60346 | 1 | phosphorylation | down-regulates | 0.353 | In addition, we show that the beta-trcp-mediated degradation requires phosphorylation of phlpp1 by casein kinase i and glycogen synthase kinase 3beta (gsk-3beta), and activation of the phosphatidylinositol 3-kinase/akt pathway suppresses the degradation of phlpp1 by inhibiting the gsk-3beta activity. | SIGNOR-188330 |
Q9H8W4 | Q15075 | 2 | binding | up-regulates activity | 0.248 | In yeast two-hybrid analysis we identified Phafin2 as a novel interactor of the endosomal-tethering protein EEA1, and Phafin2 colocalized strongly with EEA1 in microdomains of the endosome membrane. Our results suggest that Phafin2 controls receptor trafficking and fluid-phase transport through early endosomes by facil... | SIGNOR-261276 |
Q92878 | Q08999 | 2 | binding | up-regulates activity | 0.304 | We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. | SIGNOR-265029 |
Q9H0M0 | Q9Y2J4 | 1 | ubiquitination | up-regulates activity | 0.29 | AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation|Here, we provide evidence that the E3 ligase WWP1 (WW-domain containing protein 1) mono-ubiquitinates AMOTL2 (angiomotin-like 2) at K347 and K408. | SIGNOR-271873 |
P27361 | Q15788 | 1 | phosphorylation | up-regulates | 0.268 | Mapk also directly phosphorylates src-1 at thr1179 and ser1185. Phosphorylation of src-1 by mitogen-activated protein kinase (mapk) is required for optimal progesterone receptor-dependent transcription and for functional cooperation with camp response element-binding protein-binding protein | SIGNOR-91143 |
O60936 | Q05086 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Incubation of transfected HEK293T cells with the proteasome inhibitor, MG132 blocked Ube3A mediated degradation of Arc suggesting that Ube3A degrades Arc via the ubiquitin proteasome system .|The ubiquitination of Arc by Ube3A was confirmed by mass spectrometry which revealed that Ube3A catalyzed the polyubiquitination... | SIGNOR-278522 |
P67775 | Q9Y314 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.338 | NOSIP mediates the monoubiquitination of the PP2A catalytic subunit and the loss of NOSIP results in an increase in PP2A activity in craniofacial tissue in NOSIP knockout mice. | SIGNOR-271498 |
Q92985 | P63279 | 0 | sumoylation | down-regulates activity | 0.287 | One mechanism by which LMP1 regulates cellular activation is through the induction of protein posttranslational modifications. We have now identified a specific target of LMP1-induced sumoylation, interferon regulatory factor 7 (IRF7). We hypothesize that during EBV latency, LMP1 induces the sumoylation of IRF7, limiti... | SIGNOR-266837 |
Q9UQB8 | Q14678 | 2 | binding | down-regulates activity | 0.342 | In this study, we report that Kank disrupts the function of active Rac1 through IRSp53. The binding between IRSp53 and Kank inhibits the association of active Rac1 with IRSp53 rather than the association of active cdc42 with IRSp53. Kank inhibits the formation of lamellipodia and membrane ruffles induced by active Rac1... | SIGNOR-265553 |
Q16665 | P11309 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | PIM1 kinase directly phosphorylates HIF-1α at threonine 455, a previously uncharacterized site within its oxygen-dependent degradation domain. This phosphorylation event disrupts the ability of prolyl hydroxylases to bind and hydroxylate HIF-1α, interrupting its canonical degradation pathway and promoting constitutive ... | SIGNOR-277311 |
P49815 | Q05086 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.629 | An in vivo ubiquitination assay was done to reveal that E6AP promoted the ubiquitination of TSC2 independent of HPV16 E6. We further found that TSC2 bound E6AP in the presence as well as in the absence of HPV16 E6. The binding regions on E6AP and TSC2 have been identified as amino acid (aa) 260-316, aa 428-500 and aa ... | SIGNOR-271396 |
Q6IQ23 | Q86UF1 | 2 | binding | up-regulates activity | 0.4 | Using cell biological and biochemical methods, we now show that ADAM10 is docked to junctions by its transmembrane partner Tspan33, whose cytoplasmic C terminus binds to the WW domain of PLEKHA7 in the presence of PDZD11. | SIGNOR-261250 |
P05362 | Q86YJ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH-IX expression causes ubiquitination and downregulation of ICAM-1 and a short alternative transcript of MARCH-IX lacking the RING-CH domain, termed MARCH-IX RINGless, is shown to act as a positive regulator of MARCH-IX activity.|MARCH-IX mediates ubiquitination and downregulation of ICAM-1. | SIGNOR-278821 |
Q13177 | P55210 | 1 | phosphorylation | down-regulates | 0.351 | Pak2 can bind with caspase-7 and phosphorylate caspase-7 at the ser-30, thr-173, and ser-239 sites. Functionally, the phosphorylation of caspase-7 decreases its activity, thereby inhibiting cellular apoptosis. | SIGNOR-173655 |
Q13315 | P51812 | 0 | phosphorylation | up-regulates activity | 0.388 | Furthermore, using RSK2 knockout mouse fibroblasts and RSK2 deficient cells from CLS patients, we demonstrate that ablation of RSK2 impairs the phosphorylation of Atm at Ser1981 and the phosphorylation of p53 at Ser18 (mouse) or Ser15 (human) in response to genotoxic stress.|We postulate that the phosphorylation of RSK... | SIGNOR-280118 |
Q01831 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | CK2 kinase mediates XPC phosphorylation at serine 94, and also promotes recruitment of ubiquitinated XPC to the chromatin after UVB irradiation. | SIGNOR-277389 |
Q9Y271 | O95837 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257135 |
Q13224 | Q96AX9 | 0 | ubiquitination | down-regulates quantity | 0.366 | Mib2 is localized to the PSD of dendrites in hippocampal neurons and directly ubiquitinates GluN2B in a manner dependent on the non receptor tyrosine kinase Fyn.|These findings suggest that Mib2 mediates proteasome dependent degradation of GluN2B subunits, which may provide a reciprocal mechanism to SCF Fbx2 regulation... | SIGNOR-278762 |
P48058 | P17252 | 0 | phosphorylation | up-regulates | 0.57 | Receptor internalization, altered;intracellular localization | SIGNOR-97554 |
Q14790 | P51812 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.369 | The ribosomal S6 kinase 2 (RSK2) is a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins and plays a critical role in proliferation, cell cycle, and cell transformation. Here, we report that RSK2 phosphorylates caspase-8, and Thr-263 was identified as a novel caspase-8 phosphorylation site. In addition, ... | SIGNOR-272997 |
P00519 | Q8IZP0 | 2 | phosphorylation | up-regulates | 0.88 | Abi-1 is an adaptor protein for abelson kinase (c-abl). Here, we identified a new phosphorylation site (y398) in the sh3 domain of abi1, and disruption of y398, combined with the previously identified phosphorylation site y213, significantly weakens the binding of abi-1 to c-abl. Phosphorylation of abi-1 is dependent o... | SIGNOR-172017 |
P26358 | Q13131 | 0 | phosphorylation | down-regulates activity | 0.2 | Together, these results indicate that AMPK phosphorylated DNMT1-Ser730, RBBP7-Ser314, and HAT1-Ser190|AMPK decreased DNMT1 activity | SIGNOR-264783 |
P50148 | P30411 | 2 | binding | up-regulates activity | 0.458 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257090 |
Q06124 | Q96P31 | 2 | binding | up-regulates activity | 0.383 | Tyrosine phosphorylation of SPAP2a by c-Src and in vitro. Tyrosine-phosphorylated SPAP2 is specifically associated with SH2 domain-containing tyrosine kinases Syk and Zap70 and SH2 domain-containing tyrosine phosphatases SHP-1 and SHP-2. Site-specific mutagenesis studies revealed that tyrosyl residues 650 and 662 embed... | SIGNOR-274014 |
Q7Z5G4 | Q9Y397 | 2 | binding | up-regulates activity | 0.686 | DHHC9 and GCP16 form a protein complex, and DHHC9 requires GCP16 for protein fatty acyltransferase activity and protein stability. | SIGNOR-261353 |
P68431 | P45973 | 2 | binding | up-regulates activity | 0.2 | A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic pr... | SIGNOR-264490 |
P0C2W1 | O43623 | 2 | binding | down-regulates quantity by destabilization | 0.258 | One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbx... | SIGNOR-272182 |
P08908 | O95837 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257197 |
P51452 | Q8IV63 | 2 | binding | up-regulates activity | 0.704 | Vaccinia-related kinase 3 (VRK3), a member of the VRK family, is widely expressed in human tissues and increases VHR phosphatase activity through a direct binding | SIGNOR-275546 |
O75581 | O96014 | 2 | binding | up-regulates activity | 0.572 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131637 |
P24941 | P04637 | 1 | phosphorylation | up-regulates activity | 0.871 | The N-terminus of E2F1 can interact directly with a region towards the C-terminus of p53, resulting in increased nuclear retention of p53 and p53-mediated transcription and apoptosis. This is inhibited by competition between p53 and cyclin A at the binding site within E2F19,10. The interaction between p53 and E2F1 is e... | SIGNOR-119379 |
O14818 | P42684 | 0 | phosphorylation | down-regulates | 0.607 | Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-abl and arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome psma7 (alpha4) subunit at tyr-153. Consequently, proteasome-dependent proteolysis is compromised | SIGNOR-146589 |
P29590 | Q6ZNA4 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.355 | Upon TGF-β induction, interaction of Arkadia with phosphorylated Smad2 triggers degradation of SnoN, whereas upon arsenic treatment, interaction of Arkadia with poly-SUMO in PML nuclear bodies induces degradation of polysumoylated PML together with RNF4. | SIGNOR-272883 |
P36873 | O95786 | 1 | dephosphorylation | up-regulates activity | 0.2 | We identified PP1alpha and PP1gamma as primary phosphatases responsible for MDA5 and RIG-I dephosphorylation, leading to their activation.|endogenous RIG-I and MDA5 that interacted with PP1 exhibited markedly decreased phosphorylation levels at S8 and S88, respectively | SIGNOR-264580 |
Q02930 | P05412 | 2 | binding | up-regulates activity | 0.51 | CRE-BPa specifically binds to CRE as a homodimer or heterodimer with c-Jun or CRE-BP1. In CAT cotransfection experiments using CV-1 cells, transient expression of each of four CRE-BPa proteins caused a 1.6- to 3.4-fold increase of CRE-dependent transcription | SIGNOR-219634 |
P29372 | P78318 | 1 | monoubiquitination | down-regulates quantity by destabilization | 0.2 | We show MID1-dependent monoubiquitination of α4 triggers calpain-mediated cleavage and switches α4's activity from protective to destructive, resulting in increased Tau phosphorylation. MID1 serves as the E3 ligase for α4 (2B), leading to a conformational change in α4 whereby the UIM of α4 binds in cis to the covalent... | SIGNOR-272040 |
P78527 | O00743 | 0 | dephosphorylation | up-regulates activity | 0.538 | In addition, siRNA knockdown of either PP6R1 or PP6 significantly decreased IR activation of DNA-PK, suggesting that PP6 activates DNA-PK by association and dephosphorylation.|PP6 may dephosphorylate sites in DNA-PKcs to reduce binding with heterodimer Ku proteins, because DNA-PK activation completely depends on Ku-med... | SIGNOR-277164 |
Q9UKV8 | Q9Y243 | 0 | phosphorylation | up-regulates | 0.423 | Phosphorylation of argonaute 2 at serine-387 facilitates its localization to processing bodies, akt3-mediated phosphorylation of ago2 is a molecular switch between target mrna cleavage and translational repression activities of ago2 | SIGNOR-178416 |
Q9UIF8 | Q6NXT2 | 2 | binding | down-regulates activity | 0.2 | The BAZ2B bromodomain has been shown to bind to acetylated H3K14 (H3K14ac), whose presence at promoter regions is generally associated with gene activation. This suggests a potential role for BAZ2B in transcriptional activation. | SIGNOR-266621 |
P27037 | Q15796 | 1 | phosphorylation | up-regulates activity | 0.71 | In ACVR2A/B dKO parental cells, only ACVR2A , but not ACVR2A , could rescue both pSMAD2 and pSMAD1/5 (Fig\u00a04B).|In marked contrast, in ACVR2A/B dKO HOM1 cells, ACVR2A restored SMAD1/5 phosphorylation, but not SMAD2 phosphorylation (Fig\u00a04C). | SIGNOR-279786 |
P01112 | Q9Y5Z9 | 2 | binding | down-regulates activity | 0.2 | This study show that UBIAD1 interacts with H-Ras, retains H-Ras in the Golgi apparatus, prevents H-Ras trafficking from the Golgi apparatus to the plasma membrane, blocks the aberrant activation of Ras/MAPK signaling, and inhibits the proliferation of bladder cancer cells. | SIGNOR-256206 |
P04049 | P31751 | 0 | phosphorylation | down-regulates activity | 0.451 | Akt (protein kinase b), a member of a different signaling pathway that also regulates these responses, interacted with raf and phosphorylated this protein at a highly conserved serine residue in its regulatory domain in vivo. This phosphorylation of raf by akt inhibited activation of the raf-mek-erk signaling pathway a... | SIGNOR-235678 |
P34969 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257323 |
P11717 | P10144 | 2 | binding | up-regulates | 0.407 | The serine proteinase granzyme b is crucial for the rapid induction of target cell apoptosis by cytotoxic t cells. We now present evidence that this receptor is the cation-independent mannose 6-phosphate/insulin-like growth factor receptor (ci-mpr). Inhibition of the granzyme b ci-mpr interaction prevented granzyme b c... | SIGNOR-84314 |
P27361 | Q13362 | 2 | phosphorylation | down-regulates | 0.42 | Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. | SIGNOR-144317 |
Q9UL15 | O60260 | 2 | binding | down-regulates activity | 0.2 | Here, we show that BAG5, a BAG domain-containing family member, interacts with both Hsp70 and parkin with deleterious functional consequences. Through these interactions, BAG5 inhibits Hsp70 chaperone activity and parkin E3 ubiquitin ligase activity Immunoprecipitation (IP) of GFP-parkin resulted in the coimmunoprecip... | SIGNOR-261198 |
Q8N488 | P00519 | 2 | binding | down-regulates | 0.333 | We identified a novel protein, aap1 (abl-associated protein 1), that associates with these c-abl domains and fails to bind to the sh3 domain in the activated oncoprotein bcrabl. we conclude that aap1 inhibits c-abl tyrosine kinase activity | SIGNOR-45325 |
P21579 | O60641 | 2 | binding | up-regulates quantity | 0.633 | the monomeric adaptor proteins AP180/CALM and stonin-2 are required for the efficient retrieval of synaptobrevin II (sybII) and synaptotagmin-1 respectively .Stonin-2 and AP-2 are also Required for Efficient Synaptotagmin-1 Retrieval. the monomeric adaptor proteins AP180/CALM and stonin-2 are required for the efficie... | SIGNOR-264114 |
Q92834 | P61006 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.427 | PGR interacts with the small GTPase RAB8A, which participates in cilia biogenesis and maintenance. We show that RPGR primarily associates with the GDP-bound form of RAB8A and stimulates GDP/GTP nucleotide exchange. RPGR functions as a GEF for RAB8A and RPGR–RAB8A association may facilitate ciliary trafficking. | SIGNOR-253030 |
Q96SN8 | Q96MT8 | 1 | relocalization | up-regulates activity | 0.692 | Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at seq... | SIGNOR-271722 |
O60603 | P03217 | 0 | post transcriptional regulation | down-regulates quantity by repression | 0.2 | The RNA degradation induced by EBV BGLF5 can affect immunologically relevant proteins, including TLR2. Alkaline exonuclease involved in host shutoff, downregulates TLR2. | SIGNOR-266741 |
P11802 | P42773 | 2 | binding | down-regulates | 0.871 | The first group, including p16ink4a, p15ink4b,p18ink4cand p19ink4d, is specific for the g1 cdks,cdk4and cdk6, inhibiting the kinase activity of cyclin d/cdk4-cdk6 complexes on prb. | SIGNOR-44598 |
P63215 | Q99835 | 2 | binding | up-regulates | 0.2 | Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. | SIGNOR-148598 |
Q08499 | P17612 | 0 | phosphorylation | up-regulates | 0.569 | Phosphorylation and activation of a camp-specific phosphodiesterase by the camp-dependent protein kinase. | SIGNOR-42515 |
P27361 | Q14790 | 1 | phosphorylation | down-regulates | 0.717 | We demonstrate that perk 1/2 can phosphorylate pro-caspase-8 at s387 by knocking-down the endogenous pro-caspase-8 using rnai and replacing it with its non-phosphorylatable counterpart (s387a), a significant increase in caspase-8 activity | SIGNOR-203480 |
Q00987 | P36873 | 0 | dephosphorylation | up-regulates quantity by stabilization | 0.2 | Three phosphorylation sites identified are Ser342, Ser367, and Ser403. In the present study, we identify protein phosphatase 1 (PP1) as a negative regulator in the p53 signaling pathway. PP1 directly interacts with Mdmx and specifically dephosphorylates Mdmx at Ser367. The dephosphorylation of Mdmx increases its stabil... | SIGNOR-248504 |
Q86YD1 | Q96BR1 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | In this study, we find that the understudied serum and glucocorticoid-induced kinase-2 (SGK2) phosphorylates PTOV1 at S36. | SIGNOR-279283 |
Q9Y2H9 | P60484 | 1 | phosphorylation | down-regulates | 0.515 | Mast1 was found to associate to pten. | SIGNOR-138003 |
Q9HCK8 | P11137 | 1 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268916 |
P08172 | P08754 | 2 | binding | up-regulates activity | 0.403 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256828 |
P35968 | P49767 | 2 | binding | up-regulates | 0.916 | Vegf-c is also a ligand for vegfr-2 (12), but the functional significance of this potential interaction in vivo is unknown | SIGNOR-55208 |
Q13163 | Q13164 | 2 | phosphorylation | up-regulates | 0.703 | Mek5 is the mapk kinase that phosphorylates and activates erk5 in response to growth factors, oxidative stress, and hyperosmotic conditions. | SIGNOR-104631 |
P09848 | Q99626 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.362 | By electrophoretic mobility-shift assay it was shown that the factor Cdx-2 (a homoeodomain-protein related to caudal) binds to a TTTAC sequence in the CE-LPH1. Furthermore it was demonstrated that Cdx-2 is able to activate reporter gene transcription by binding to CE-LPH1. | SIGNOR-253964 |
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