IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P14598 | Q9HBY0 | 2 | binding | up-regulates activity | 0.626 | Stimulus-induced phosphorylation of p47phox causes a conformational change, by which both PX and SH3 domains become accessible to their membranous targets, phosphoinositides and p22phox, respectively. Cooperation of these two interactions, each being indispensable, enables p47phox to form a stable complex with cytochro... | SIGNOR-276624 |
P17612 | P49841 | 1 | phosphorylation | down-regulates activity | 0.557 | Gsk3 is different from most kinases in that it is constitutively partially active and the most common regulatory mechanism is inhibition by phosphorylation of ser21 in gsk3alpha or ser9 in gsk3beta. This inhibitory phosphorylation can be mediated by several kinases, such as akt/protein kinase b (pkb), protein kinase c ... | SIGNOR-188577 |
P50148 | P21452 | 2 | binding | up-regulates activity | 0.462 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257015 |
P31749 | Q5UE93 | 1 | phosphorylation | up-regulates activity | 0.45 | P84 forms a negative regulatory complex with p110gamma to control PI3Kgamma signalling during cell migration|However, phosphorylation at this site was confirmed using an in vitro kinase assay in which Akt kinase was shown to readily phosphorylate Thr607 using a p84 peptide (Figure 1e), where Thr607 in conjunction with ... | SIGNOR-275722 |
O15151 | P04637 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.948 | Here we demonstrate that MdmX acts as a ubiquitin ligase in vitro, being capable of autoubiquitination, as well as mediating the ubiquitination of p53. | SIGNOR-271389 |
P54252 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | Here we show that protein casein kinase 2 (CK2)-dependent phosphorylation controls the nuclear localization, aggregation and stability of ataxin-3 (ATXN3), the disease protein in spinocerebellar ataxia type 3 (SCA3). The main phosphorylation of ATXN3 in vivo thus occurred at serine residues within the three conserved U... | SIGNOR-276224 |
P18031 | Q13882 | 1 | dephosphorylation | down-regulates activity | 0.575 | Using a variety of PTEN mutant constructs, we show that protein phosphatase activity of PTEN targets PTK6, with efficiency similar to PTP1B, a phosphatase that directly dephosphorylates PTK6 Y342. | SIGNOR-277082 |
Q9H6Z4 | P51812 | 0 | phosphorylation | up-regulates quantity | 0.328 | RSK phosphorylates RanBP3 at Serine 58 residue in vitro and in vivo.RanBP3 phosphorylation increases its affinity towards Ran | SIGNOR-276148 |
Q13625 | P04637 | 2 | binding | up-regulates | 0.898 | 53bp2 interacts with the tumour suppressor p53 and enhances p53-mediated activation of transcription, possibly by facilitating the dephosphorylation of one or more sites on p53 | SIGNOR-114762 |
Q9Y4P1 | O75385 | 0 | phosphorylation | down-regulates activity | 0.614 | Here we find that ULK1, a protein kinase activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316.|Thus ULK1 is able to inhibit LC3 processing by a direct effect on ATG4B, possibly by phosphorylation of a serine residue of ATG4B.Fig. 1ULK1 inhibits ATG4B-mediated LC3 cleavage. a Average A... | SIGNOR-279434 |
Q00526 | P06400 | 1 | phosphorylation | down-regulates | 0.443 | The active form of prb is underphosphorylated. Cdk3/cyclin-c-mediated phosphorylation at ser-807 and ser-811 is required for g0-g1 transition. | SIGNOR-124212 |
P15311 | O94804 | 0 | phosphorylation | up-regulates activity | 0.473 | Ezrin activation by LOK phosphorylation involves a PIP 2 -dependent wedge mechanism.|The specificity of kinases depends on local peptide consensus sequences, which in the case of ezrin phosphorylation by LOK involves the hydrophobic residue Y565 positioned -2 residues from T567. | SIGNOR-278204 |
P68871 | P19338 | 0 | post transcriptional regulation | up-regulates quantity by expression | 0.2 | Nucleolin binds human β-globin mRNA. A Nucleolin-Binding 3′ Untranslated Region Element Stabilizes β-Globin mRNA In Vivo | SIGNOR-251844 |
P35398 | P28482 | 0 | phosphorylation | down-regulates | 0.26 | We identified the extracellular signal-regulated kinase 2 (erk-2) as roralpha4 phosphorylating kinase in vitro. The primary sequence of roralpha4 contains an erk-2 recognition motif (p-l-t(128)-p) within the hinge domain, and mutation of thr-128 to ala prevents roralpha4 phosphorylation by erk. The roralpha4-t128a muta... | SIGNOR-154914 |
P06241 | P52209 | 1 | phosphorylation | up-regulates activity | 0.2 | 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA syn... | SIGNOR-265758 |
P48729 | Q9NRF8 | 1 | phosphorylation | down-regulates | 0.2 | Hctps2 ser(568) was phosphorylated by casein kinase 1 both in vitro and in vivo. Mutation of ser(568) (s568a) significantly increased hctps2 activity, demonstrating that ser(568) is a major inhibitory phosphorylation site. | SIGNOR-167623 |
P63096 | Q9UBY5 | 2 | binding | up-regulates activity | 0.458 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256890 |
O75116 | Q96A00 | 1 | phosphorylation | up-regulates activity | 0.413 | A major kinase for GPCR‐induced CPI‐17 phosphorylation is PKC which is activated by the PLCbeta‐produced signaling messenger diacylglycerol (DAG). It phosphorylates CPI‐17 at Thr38 residue that directly docks at the active site of MLCP, thereby inhibiting its activity and promoting an increase of phosphorylation of myo... | SIGNOR-96696 |
Q96C90 | Q13418 | 0 | phosphorylation | up-regulates activity | 0.398 | We conclude that ILK may activate smooth-muscle contraction both directly, via phosphorylation of myosin, and indirectly, via phosphorylation and activation of CPI-17 and PHI-1, leading to inhibition of MLCP.|CPI-17 and PHI-1 thiophosphorylated by ILK at Thr(38) or Thr(57) respectively inhibited myosin light-chain phos... | SIGNOR-265741 |
P63104 | P55040 | 2 | binding | up-regulates quantity by stabilization | 0.303 | In order to address whether Gem binds specific isoforms of 14-3-3, we determined the coassociation of Gem and 14-3-3 in the neuroblastoma cell line SY5Y. 14-3-3ζ, -γ, -τ, and -β were observed to bind to Gem. 14-3-3-bound Gem has a twofold-longer half-life than nonbound Gem (Fig. (Fig.6).6). A similar increase in prote... | SIGNOR-261715 |
P62136 | Q70Z35 | 1 | dephosphorylation | up-regulates activity | 0.2 | PREX2 is dephosphorylated by PP1α and PP2A.PAK-mediated phosphorylation of PREX2 reduced GEF activity toward Rac1 by inhibiting PREX2 binding to PIP3 and Gβγ. | SIGNOR-277183 |
P11279 | Q9NR19 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GU... | SIGNOR-276556 |
Q15208 | P49841 | 0 | phosphorylation | down-regulates activity | 0.278 | GSK-3β phosphorylated STK38 on residues S6 and T7 in vitro, depending largely on a PKA-mediated priming phosphorylation of STK38 on residues S10 and S11, respectively. Our results indicate that that GSK-3β inhibits STK38's full activation, and suggest that STK38 activation is required to prevent cell death in response... | SIGNOR-276392 |
O75509 | P01375 | 2 | binding | up-regulates | 0.337 | We report the identification and initial characterization of dr6, a new member of the tnf receptor family possessing a cytoplasmic death domain. | SIGNOR-59745 |
Q16539 | P15923 | 1 | phosphorylation | up-regulates activity | 0.48 | Here we show that p38 mapk, whose activity is essential for myogenesis, regulates myod/e47 heterodimerization. Phosphorylation of e47 at ser140 by p38 induces myod/e47 association and activation of muscle-specific transcription | SIGNOR-134194 |
O60674 | P42229 | 1 | phosphorylation | up-regulates activity | 0.866 | Jak2 kinase induces tyrosine phosphorylation, dimerization, nuclear translocation, and dna binding of a concomitantly expressed stat5 protein | SIGNOR-249507 |
P27361 | P17535 | 1 | phosphorylation | up-regulates | 0.459 | Menin binds the jun family transcription factor jund and inhibits its transcriptional activity. The menin-jund interaction blocks jun n-terminal kinase (jnk)-mediated jund phosphorylation and suppresses jund-induced transcription. We found a role for phosphorylation of the ser100 residue of jund;jund phosphorylation we... | SIGNOR-196034 |
P37231 | P03372 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.28 | Our data show for the first time that eralpha binds to ppar response element and represses its transactivation | SIGNOR-140233 |
Q96A00 | Q13625 | 2 | binding | down-regulates | 0.2 | The phosphorylase phosphatase activity of pp1 was inhibited by p53bp2 at nanomolar concentrations. | SIGNOR-39666 |
P36873 | O15169 | 1 | dephosphorylation | down-regulates activity | 0.269 | The data suggest that PP1 controls Wnt signaling through interaction with, and regulated dephosphorylation of, axin| Axin phosphorylation markedly enhances the binding of glycogen synthase kinase 3, leading to a more active beta-catenin destruction complex. Wnt-regulated changes in axin phosphorylation, mediated by PP1... | SIGNOR-248494 |
P21802 | Q8WU20 | 1 | phosphorylation | up-regulates activity | 0.777 | In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. | SIGNOR-236950 |
P07737 | P55283 | 1 | null | up-regulates activity | 0.335 | Taken together, data obtained from MCF10A cells were consistent with the idea that Rho signaling to Dia1 and profilin-1 was essential for R-cadherin adherens junction formation. | SIGNOR-253111 |
Q9Y4C0 | Q8NFZ3 | 2 | binding | up-regulates activity | 0.2 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264163 |
P29474 | P08238 | 2 | binding | up-regulates activity | 0.547 | Here we show that Hsp90 associates with endothelial nitric oxide synthase (eNOS) and is rapidly recruited to the eNOS complex by agonists that stimulate production of nitric oxide, namely vascular endothelial growth factor, histamine and fluid shear stress. Moreover, the binding of Hsp90 to eNOS enhances the activation... | SIGNOR-252214 |
Q8IXJ6 | P15172 | 1 | deacetylation | down-regulates | 0.376 | Sir2-mediated deacetylation of myod can be expected to inhibit its transcriptional capabilities. | SIGNOR-104251 |
Q14012 | O00429 | 1 | phosphorylation | up-regulates activity | 0.333 | For example, protein kinase A (PKA) phosphorylation of Drp1S600 has been reported to decrease Drp1 GTPase activity in vitro (23, 24), whereas phosphorylation of the same conserved serine residue by Ca2+-calmodulin–dependent protein kinase Iα (CaMKIα) in Drp1 isoform 3 has been reported to cause a significant increase i... | SIGNOR-262552 |
P04150 | P45983 | 0 | phosphorylation | down-regulates | 0.638 | Taken together, these findings suggest that jnk-mediated phosphorylation of the gr-ser226 enhances gr nuclear export and may contribute to termination of gr-mediated transcription. | SIGNOR-93558 |
O75122 | Q15691 | 2 | binding | up-regulates activity | 0.632 | GSK-3beta directly phosphorylates CLASP2 at Ser533 and Ser537 within the region responsible for the IQGAP1 binding. Phosphorylation of CLASP2 results in the dissociation of CLASP2 from IQGAP1, EB1 and microtubules.| CLASPs were originally identified as CLIP-170-interacting proteins and later found to be required for mi... | SIGNOR-264829 |
Q9UI10 | P49841 | 2 | binding | down-regulates | 0.2 | Akt also promotes protein synthesis by phosphorylating and inactivating gsk3b, thus releasing the gsk3b-dependent inhibition of the eukariotic translation initiation factor 2b (eif2b). | SIGNOR-175572 |
P00748 | P03952 | 2 | cleavage | up-regulates activity | 0.606 | FXIIa activates two serine proteinases, factor XI (FXI) and plasma prekallikrein (PK) that drive the coagulation and kallikrein–kinin systems, respectively | SIGNOR-263518 |
O94992 | Q9UGL1 | 1 | relocalization | up-regulates activity | 0.2 | We previously reported that the tumor suppressor HEXIM1 is a mediator of KDM5B recruitment to its target genes, and HEXIM1 is required for the inhibition of nuclear hormone receptor activity by KDM5B. | SIGNOR-273439 |
P00533 | P48431 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.48 | These data indicate that EGFR\u2010induced SOX2 Tyr277 phosphorylation prevents the autophagic degradation of SOX2 and enhances its stability. | SIGNOR-279036 |
P07900 | P05129 | 0 | phosphorylation | down-regulates | 0.258 | Threonine residue set, thr(115)/thr(425)/thr(603), of hsp90_ is specifically phosphorylated by pkc_phosphorylation of hsp90_ by pkc_ decreases the binding affinity of hsp90_ towards atp and co-chaperones such as cdc37 (cell-division cycle 37), thereby decreasing its chaperone activity. | SIGNOR-202812 |
P05230 | Q05655 | 0 | phosphorylation | up-regulates quantity | 0.2 | Translocated FGF1 can be phosphorylated by PKC\u03b4 on serine 130. | SIGNOR-278451 |
P48552 | P28702 | 2 | binding | up-regulates | 0.603 | Receptor interacting protein 140 (rip140) is a coregulator for a large number of transcription factors. Rip140 interacts with retinoic acid receptor (rar) and retinoid x receptor (rxr) with or without ligands | SIGNOR-95160 |
P25098 | P27361 | 0 | phosphorylation | down-regulates | 0.2 | Erk1 phosphorylates grk2 at ser(670). Inhibition of erk activity in hek293 cells potentiates grk2 activity, whereas, conversely, erk activation inhibits grk2 activity. | SIGNOR-72582 |
P05129 | P19429 | 1 | phosphorylation | down-regulates | 0.2 | Phosphorylation at ser 23/24 (e.g., by pka or pkg) results in reduction in myofilament ca2+ sensitivity and an increase in crossbridge cycling rate, leading to acceleration of relaxation and an increase in power output but a reduced economy of contraction. Conversely, phosphorylation at ser 43/45 (by pkc) is associated... | SIGNOR-134632 |
P0DP24 | O00418 | 2 | binding | up-regulates | 0.461 | The calmodulin-binding region is located between amino acids 51 and 96 | SIGNOR-266321 |
Q92934 | O14920 | 0 | phosphorylation | down-regulates | 0.263 | Ikk phosphorylates bad at serine-26 (ser26) and primes it for inactivation. | SIGNOR-192614 |
P49137 | Q9UKV8 | 1 | phosphorylation | up-regulates | 0.436 | Mk2 was found to phopsphorylate in vitro the ago2 protein in ser387, which was identified as the major ago2 phosphorylation site in cells.and mutation of ser387 to alanineimpairsago2 localization to therna-containing granules termedprocessing bodies | SIGNOR-166615 |
Q9H257 | P40337 | 2 | binding | down-regulates activity | 0.393 | We found that pVHL associates with the NF-kappaB agonist Card9 but does not target Card9 for destruction. Instead, pVHL serves as an adaptor that promotes the phosphorylation of the Card9 C terminus by CK2. | SIGNOR-257603 |
O14543 | P40763 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.709 | We also found that the wild type SOCS-3 promoter construct has significantly greater activity in non-small-cell lung cancer cell lines than in normal cells in accordance with STAT3 disregulation in these cells | SIGNOR-253583 |
P16220 | Q9Y4H2 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.342 | Taken together, these results indicate that the IRS2 gene is a direct target for CREB action in vivo | SIGNOR-278145 |
Q13387 | Q9UQF2 | 2 | binding | up-regulates | 0.656 | Deletion analysis demonstrated that the cooh-terminal regions of jip1 and jip2 were sufficient for the formation of hetero-oligomeric complexes | SIGNOR-70863 |
P63211 | P48736 | 2 | binding | up-regulates | 0.487 | Therefore, we conclude that in vivo, g beta gamma activates pi3k gamma by a mechanism assigning specific roles for both pi3k gamma subunits, i.e., membrane recruitment is mediated via the noncatalytic p101 subunit, and direct stimulation of g beta gamma with p110 gamma contributes to activation of pi3k gamma. | SIGNOR-96831 |
P10636 | P17612 | 0 | phosphorylation | down-regulates | 0.433 | However, other kinases, such as cdk5, p38 and pka, also phosphorylate tau at t231tau phosphorylation at t231, s235 and s262 also contributes to the dissociation of tau from microtubules | SIGNOR-171066 |
P63092 | O15552 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256803 |
Q14164 | P46937 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.44 | Virus-activated kinase IKKɛ phosphorylated YAP at Ser403 and thereby triggered degradation of YAP in lysosomes and, consequently, relief of YAP-mediated inhibition of the cellular antiviral response. | SIGNOR-277355 |
Q9UHC7 | P60484 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.43 | EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase.|In fact, epidermal growth factor-stimulated pAKT phosphorylates and subsequently stabilizes MKRN1, which then ubiquitinates and induces the degradation of PTEN. | SIGNOR-278830 |
P29275 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257307 |
P06400 | P24941 | 0 | phosphorylation | down-regulates | 0.884 | We demonstrate that phosphorylation by either cdk2-cyclin a, which phosphorylates t821, or cdk4-cyclin d1, which phosphorylates threonine 826, can disable prb for subsequent binding of an lxcxe protein. | SIGNOR-47895 |
P27361 | Q86UR1 | 1 | phosphorylation | down-regulates | 0.267 | Accumulating evidence indicates that protein phosphorylation regulates nox activity. In this report, we show that serine282 residue of nox activator 1 (noxa1) is phosphorylated by erk in response to egf resulting in desensitization of nox1 activity | SIGNOR-164231 |
Q14680 | P30305 | 1 | phosphorylation | down-regulates activity | 0.533 | In the present study we show that the human pEg3 kinase is able to specifically phosphorylate CDC25B in vitro. One phosphorylation site was identified and corresponded to serine 323[Ä] Taken together these results suggest that pEg3 is a potential regulator of the G2/M progression and may act antagonistically to the CDC... | SIGNOR-255655 |
P36896 | Q96S42 | 2 | binding | up-regulates activity | 0.642 | Nodal effects are dependent upon interactions with Cripto, a small cysteine-rich extracellular protein that is attached to the plasma membrane through a glycosyl phosphatidyl inositol linkage. Cripto interacts with Nodal and ALK4, independently, and promotes the formation of a stable high affinity complex with activin ... | SIGNOR-251939 |
P06493 | Q5FWF5 | 1 | phosphorylation | down-regulates | 0.474 | We show here that eco1 degradation requires the sequential actions of cdk1 and two additional kinases , cdc7-dbf4 and the gsk-3 homolog mck1. | SIGNOR-200400 |
P00533 | P09211 | 1 | phosphorylation | up-regulates | 0.437 | Taken together, these results and those of the ms/ms analyses confirmed tyr-3, tyr-7, and tyr-198 to be primary residues phosphorylated by egfr in the gstp1 protein. The phosphorylation increased gstp1 enzymatic activity significantly, | SIGNOR-184387 |
Q08345 | Q08345 | 2 | phosphorylation | up-regulates activity | 0.2 | The discoidin domain receptor tyrosine kinases are activated by collagen | Here, we present evidence that stimulating DDR1- and DDR2-expressing cells with various types of collagen induces receptor autophosphorylation. | SIGNOR-251086 |
Q9UNH5 | P06493 | 0 | phosphorylation | up-regulates activity | 0.54 | We found that Cdc14A is phosphorylated on Ser411, Ser453 and Ser549 by Cdk1 early in mitosis and becomes dephosphorylated during late mitotic stages. | SIGNOR-278264 |
Q9NRM7 | P38936 | 1 | phosphorylation | down-regulates quantity | 0.417 | Phosphorylation by Lats2 induces degradation of p21 and promotes apoptosis.|Subsequently, Lats2 phosphorylates p21 at S146. | SIGNOR-279530 |
Q13131 | Q16236 | 1 | phosphorylation | up-regulates activity | 0.2 | MS-based analysis of immunoprecipitated Nrf2 revealed serine 374, 408 and 433 in human Nrf2 to be hyperphosphorylated as a function of activated AMPK. A direct phosphate-transfer by AMPK to those sites was indicated by in vitro kinase assays with recombinant proteins as well as interaction of AMPK and Nrf2 in cells, ev... | SIGNOR-277496 |
P15509 | O60674 | 2 | binding | up-regulates activity | 0.533 | JAK2 is a primary kinase regulating all the known activities of GM-CSF. JAK2 mediates GM-CSF induced c-fos activation through receptor phosphorylation and Shc/PTP 1D activation. | SIGNOR-249502 |
Q9Y4G8 | P62834 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.789 | Our data are consistent with a pathway involving the cAMP-mediated activation of Rapgef2, which then stimulates Rap1, leading to increases in B-Raf, MEK, and ERK activity.Increased intracellular concentrations of cAMP enhanced the Rapgef2-dependent activation of Rap1, which in turn associated with B-Raf to enable the a... | SIGNOR-276609 |
P98066 | P17676 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.302 | In cotransfection experiments, the C/EBP beta protein trans-activated 10-15-fold the cAspAT gene promoter in HepG2 cells. | SIGNOR-254055 |
P56537 | P05771 | 0 | phosphorylation | down-regulates activity | 0.307 | Our results show that release of eIF6 from 60S subunits may operate, in mammalian cells, through a RACK1–PKC betaII pathway. |Loading 60S subunits with eIF6 caused a dose-dependent translational block and impairment of 80S formation, which were reversed by expression of RACK1 and stimulation of PKC in vivo and in vitro... | SIGNOR-249245 |
P09467 | Q13263 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.31 | In this study, we demonstrated that the tripartite motif-containing protein 28 (TRIM28) binds directly to and promotes FBP1 for ubiquitination and degradation. MAGE-A3 and MAGE-C2, which are known to be overexpressed in HCC, can enhance TRIM28-dependent degradation of FBP1 by forming ubiquitin ligase complexes with TRI... | SIGNOR-267591 |
O75914 | P17600 | 1 | phosphorylation | up-regulates activity | 0.334 | Synapsin I is phosphorylated at Ser603 by p21-activated kinases. the Ser603 residue must be one of the pivotal sites for the release | SIGNOR-250246 |
Q08050 | Q14680 | 0 | phosphorylation | up-regulates activity | 0.501 | MELK Activates FOXM1 Transcriptional Activity Leading to Upregulation of Mitotic Gene Expression.|The autoradiogram clearly shows in vitro phosphorylation of FOXM1 by MELK and CDK2 and cyclinA. | SIGNOR-278412 |
P21802 | P12034 | 2 | binding | up-regulates | 0.702 | Fgf-5 can bind and induce autophosphorylation of human fgf receptors (fgfr) 1 and 2 | SIGNOR-38995 |
Q13237 | P48436 | 1 | phosphorylation | down-regulates activity | 0.501 | Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines|Prkg2 transfected glioma cell lines express a functional cGKII that can phosphorylate VASP and Sox9. | SIGNOR-278985 |
Q7L523 | Q8N8N0 | 0 | polyubiquitination | down-regulates activity | 0.74 | Here, we identified the lysosome-anchored E3 ubiquitin ligase RNF152 as an essential negative regulator of the mTORC1 pathway by targeting RagA for K63-linked ubiquitination. RNF152 interacts with and ubiquitinates RagA in an amino-acid-sensitive manner. The mutation of RagA ubiquitination sites abolishes this effect ... | SIGNOR-272222 |
P23471 | Q9UM73 | 1 | dephosphorylation | down-regulates | 0.545 | Rptpbeta/zeta dephosphorylates alk at the site(s) in alk that is undergoing autophosphorylation through autoactivation. | SIGNOR-157227 |
P51149 | P20339 | 2 | binding | down-regulates activity | 0.699 | The absence of active Rab7 prolongs ALS2presence and Rab5 activation on macropinosomes, indicating that activeRab7 is necessary for Rab5 inactivation through ALS2 dissociation and playskey roles in the Rab switch on macropinosomes. Taken together, active Rab7is necessary for Rab5 down-regulation through ALS2dissociatio... | SIGNOR-277780 |
P50750 | P04637 | 1 | phosphorylation | up-regulates | 0.535 | We recently demonstrated that through their physical interaction, cdk9 phosphorylates p53 on ser-392, leading to p53 stability and accumulation | SIGNOR-201935 |
P68400 | P11413 | 1 | phosphorylation | up-regulates activity | 0.2 | CK2 phosphorylates G6PD T145 under ionizing radiation | SIGNOR-277890 |
P10912 | Q9HD43 | 0 | dephosphorylation | down-regulates activity | 0.295 | Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that have substrate specificity for the phosphorylated human GH receptor (... | SIGNOR-248802 |
Q8NEZ5 | Q00987 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | SCFFBXO22 targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis|we discovered Skp1-Cullin 1-FBXO22-ROC1 (SCFFBXO22) as the most dominating HDM2 E3 ubiquitin ligase from human proteome. The results of protein decay rate analysis, ubiquitination, siRNA-mediated silencing, and coimmunopreci... | SIGNOR-273440 |
P49840 | P01106 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.406 | Similar to c-myc, similar to c-myc, we report here that phosphorylation of c-jun by gsk3 creates a high-affinity binding site for the e3 ligase fbw7, which targets c-jun for polyubiquitination and proteasomal degradation. | SIGNOR-138596 |
P25963 | P19838 | 2 | binding | down-regulates activity | 0.74 | Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription... | SIGNOR-17688 |
P38398 | Q96RL1 | 2 | binding | up-regulates | 0.91 | Rap80 specifically recruits brca1 to dna damage sites and functions with brca1 in g2/m checkpoint control | SIGNOR-155201 |
P17676 | P23771 | 2 | binding | down-regulates | 0.352 | In the present study, we demonstrate that both gata-2 and gata-3 form protein complexes with ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpbeta, members of a family of transcription factors that are integral to adipogenesis. []the interaction between gata and c/ebp factors is critical for the ability of ga... | SIGNOR-132952 |
P27695 | Q03468 | 2 | binding | down-regulates activity | 0.418 | CSB stimulates the AP site incision activity of APE1 on normal (i.e. fully paired) and bubble AP-DNA substrates, with the latter being more pronounced (up to 6-fold). This activation is ATP-independent, and specific for the human CSB and full-length APE1 protein. CSB and APE1 were also found in a common protein complex... | SIGNOR-251932 |
Q13683 | P29692 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | alpha7 Integrin Expression Is Negatively Regulated by deltaEF1 during Skeletal Myogenesis | SIGNOR-241773 |
P03372 | Q15418 | 0 | phosphorylation | up-regulates | 0.494 | Serine 167 is the major phosphorylation site on the human estrogen receptor. Phosphorylation is mediated by casein kinase ii. | SIGNOR-34113 |
Q13480 | P27361 | 0 | phosphorylation | up-regulates activity | 0.633 | Our results demonstrate that ERK1/2 phosphorylate Gab1 at six serine/threonine residues (T312, S381, S454, T476, S581, S597) in consensus motifs for MAP kinase phosphorylation. |serine and threonine phosphorylation are capable of modulating the initial signal | SIGNOR-249464 |
P49023 | Q15256 | 0 | dephosphorylation | down-regulates activity | 0.2 | Here, we show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88 (Y88) in colorectal cancer (CRC) cells. We engineered CRC cells homozygous for a paxillin Y88F knock-in mutant and found that these cells exhibit significantly reduced cell mi... | SIGNOR-248720 |
P19784 | P52655 | 1 | phosphorylation | up-regulates activity | 0.374 | We now show that human TFIIA is phosphorylated in vivo on serine residues that are partially conserved between yeast and human TFIIA large subunits. Alanine substitution mutation of serine residues 316 and 321 in TFIIA alphabeta reduced TFIIA phosphorylation significantly in vivo. Additional alanine substitutions at se... | SIGNOR-250996 |
O95166 | Q14596 | 2 | binding | up-regulates | 0.757 | We performed glutathione s-transferase (gst) pull-down assays using extracts from hek293 cells overexpressing an ha-tagged nbr1(d50r) mutant, which lacks the ability to bind p62 (lamark et al., 2003) (figures s1a and s1b, available online), and gst fusions of six human atg8 homologs: gabarap, gabarapl1, gabarapl2, lc3a... | SIGNOR-184261 |
Q9UQB9 | P25963 | 1 | phosphorylation | up-regulates activity | 0.2 | AURKC directly induces IkappaBalpha activation via an interaction between the two proteins, leading to phosphorylation of IkappaBalpha.|AURKC phosphorylates IkappaBalpha on S32 and binds its ankyrin repeat domain. | SIGNOR-278470 |
O14733 | Q9UPT6 | 2 | binding | up-regulates | 0.7 | These data demonstrate that jip3 interacts with proteins that can form a mapk signaling module, including jnk, mkk7, and mlk3 | SIGNOR-73906 |
Q99759 | O00141 | 0 | phosphorylation | down-regulates activity | 0.2 | Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 2 | SIGNOR-101216 |
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