IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P78352 | P35637 | 0 | post transcriptional regulation | up-regulates quantity | 0.27 | These results point toward a novel mechanism by which FUS targets neuronal mRNA and given that these PSD-95 and Shank1 3'-UTR G quadruplex structures are also targeted by the fragile X mental retardation protein (FMRP), they raise the possibility that FUS and FMRP might work together to regulate the translation of thes... | SIGNOR-262103 |
P31749 | O60285 | 1 | phosphorylation | up-regulates | 0.262 | Ser(600) in ark5 was found to be phosphorylated by active akt resulting in the activation of kinase activity. | SIGNOR-252591 |
P31269 | O00255 | 0 | methylation | up-regulates quantity by expression | 0.477 | Men1 excision causes reduction of Hoxa9 expression, colony formation by hematopoietic progenitors, and the peripheral white blood cell count. Menin directly activates Hoxa9 expression, at least in part, by binding to the Hoxa9 locus, facilitating methylation of H3K4, and recruiting the methylated H3K4 binding protein c... | SIGNOR-255894 |
P08476 | P19883 | 2 | binding | down-regulates activity | 0.846 | Blocking activin action by pre-treatment with its binding protein, follistatin, modifies the inflammatory cytokine cascade, and reduces the severity of the subsequent inflammatory response and mortality | SIGNOR-235134 |
P35222 | P55291 | 2 | binding | up-regulates activity | 0.635 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265854 |
P43657 | O95837 | 2 | binding | up-regulates activity | 0.422 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257212 |
P59595 | P35354 | 1 | transcriptional regulation | up-regulates activity | 0.2 | SARS-CoV N protein activates COX-2 promoter and induces COX-2 protein expression | SIGNOR-262314 |
A2RUS2 | Q6IQ22 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.624 | ULK-mediated phosphorylation of the guanine nucleotide exchange factor DENND3 at serines 554 and 572 upregulates its GEF activity toward the small GTPase Rab12.|active Rab12 facilitates autophagosome trafficking, thus establishing a crucial role for the ULK/DENND3/Rab12 axis in starvation-induced autophagy. | SIGNOR-264734 |
Q12791 | P17252 | 0 | phosphorylation | up-regulates | 0.2 | Results showed that mutating s1076 altered the effect of pkc activation on bk(ca) channels in hek-293 cells | SIGNOR-186755 |
P29375 | P60484 | 1 | transcriptional regulation | down-regulates quantity by destabilization | 0.289 | The retinoblastoma binding protein 2 (RBP2) belongs to the KDM5 family, and is also known as JARID1A or KDM5A. We found that histone H3 lysine 4 (H3K4) demethylase RBP2 expression is negatively correlated with BCR-ABL expression, which suggests a regulatory link between these two genes. We also discovered that RBP2 med... | SIGNOR-260079 |
Q9NWF9 | Q13546 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.503 | Triad3A promotes proteolytic degradation of adapter proteins. Triad3A promotes down-regulation of TIRAP, TRIF, and RIP1 proteins. | SIGNOR-271608 |
P59595 | P63279 | 0 | sumoylation | up-regulates activity | 0.2 | In this study, we identified Ubc9 as a host protein that interacts specifically with SARS-CoV N protein. This interaction was verified both in vivo and in vitro. Furthermore, we showed that, in addition to phosphorylation, the N protein was modified by covalent attachment of SUMO to its lysine 62 residue. Evidence prov... | SIGNOR-260263 |
P54132 | Q9BX63 | 2 | binding | up-regulates quantity by stabilization | 0.656 | In this work, FANCJ and BLM were found to interact physically and functionally in human cells and co-localize to nuclear foci in response to replication stress. The cellular level of BLM is strongly dependent upon FANCJ, and BLM is degraded by a proteasome-mediated pathway when FANCJ is depleted. | SIGNOR-259186 |
Q9UNE7 | P10275 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.478 | Via this mechanism, CHIP ubiquitinates and degrades glucocorticoid receptor (GR), androgen receptor (AR), estrogen receptor (ER), ErbB2, and alpha-synuclein, only when bound to Hsp . | SIGNOR-278782 |
Q13588 | P08581 | 2 | binding | up-regulates | 0.269 | To efficiently promote transformation met requires direct binding with grb2. | SIGNOR-42358 |
P41159 | P48357 | 2 | binding | up-regulates | 0.814 | Both ob-ra and ob-rb bind leptin with the same affinity, whereas only ob-rb can elicit intracellular response | SIGNOR-55656 |
P01178-PRO_0000020495 | P01178-PRO_0000020496 | 2 | binding | up-regulates quantity | 0.2 | Neurophysins I and II (NPI and NPII) serve in the neurosecretory granules of the posterior pituitary as carrier proteins for the neurophyseal hormones oxytocin (OT) and vasopressin (VP), respectively, until the latter are released into blood. | SIGNOR-270351 |
P50148 | P28336 | 2 | binding | up-regulates | 0.472 | G-proteins of the q family have been implicated as mediators of bombesin receptors action. This suggests that nmb-r couples to g?q, and that grp-r and nmb-r show distinct g-protein coupling preferences in the xenopus oocyte. | SIGNOR-35864 |
O60716 | P33151 | 2 | binding | up-regulates quantity by stabilization | 0.776 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252126 |
P17252 | Q96RI1 | 1 | phosphorylation | up-regulates | 0.325 | Phosphorylation of farnesoid x receptor by protein kinase c promotes its transcriptional activity. pkcalpha phosphorylates in vitro fxr in its dna-binding domain on s135 and s154. | SIGNOR-180537 |
Q96JC1 | P37173 | 2 | binding | up-regulates activity | 0.325 | TLP interacts with TGF-β and activin receptors in vivo. Endogenous TLP associates with both active and kinase-deficient TGF-beta and activin type II receptors, but interacts with the common-mediator Smad4 only in the presence of TGF-beta/activin signaling. | SIGNOR-261374 |
P41594 | Q02156 | 0 | phosphorylation | up-regulates activity | 0.396 | Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839. | SIGNOR-249288 |
Q9Y5H9 | Q9Y5H3 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265682 |
P48729 | O15169 | 1 | phosphorylation | up-regulates activity | 0.785 | Four sites, S80, S82, S222, and S473, were identified to be PP1 regulated (Supplementary Figure 3). Three of them (S80, S82, and S473) were also phosphorylated in vitro by CKI and are conserved between axin1 and axin2/conductin.|This suggests that cumulative phosphorylation of axin is required for it to fully downregul... | SIGNOR-249191 |
P24530 | P09471 | 2 | binding | up-regulates activity | 0.456 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257254 |
P09874 | P78527 | 0 | phosphorylation | down-regulates activity | 0.525 | Therefore, through its interaction with Ku70/80 in the presence of dsDNA , DNA-PK phosphorylated PARP-1 at its catalytic CTD. | SIGNOR-280093 |
P17612 | O00408 | 2 | binding | down-regulates activity | 0.368 | We show that caffeine, by inhibiting PDE2, enhances PKA phosphorylation leading to mitochondrial NCLX activation, thereby reducing neuronal excitotoxicity and enhancing learning in mice. | SIGNOR-275730 |
Q99497 | Q8IW41 | 0 | phosphorylation | up-regulates activity | 0.469 | PRAK preferentially colocalizes with DJ-1 and leads to DJ-1 activation, which in turn facilitates DJ-1 to sequester Daxx in the nucleus, preventing oxidative stress induced cell death.|These data clearly demonstrate a PRAK dependent phosphorylation of DJ-1. | SIGNOR-279746 |
P08047 | P27361 | 0 | phosphorylation | up-regulates | 0.653 | We showed that perifosine activates the mitogen-activated protein/extracellular signal-regulated kinase pathway, and this activation promotes the phosphorylation of sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased sp1 binding and enhanced p21(waf1/cip1) transc... | SIGNOR-248062 |
Q9UNE7 | Q9ULG1 | 1 | ubiquitination | up-regulates activity | 0.2 | Then, by an in vivo ubiquitination assay under denaturing conditions (hereafter, all in vivo ubiquitination assays were carried out under denaturing conditions), we determined whether CHIP ubiquitinates Ino80.|We also show that CHIP works together with BAP1 to enhance the stabilization of Ino80, leading to its chromati... | SIGNOR-278646 |
Q5XPI4 | P45973 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | In the present study, we report that HP1α and β undergo proteasomal degradation in lamin A/C knock-down cells and show by ectopic expression, RNAi and binding studies that the RING finger ubiquitin ligase RNF123 is directly involved in HP1 degradation. | SIGNOR-272035 |
Q9HAU4 | P49910 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.268 | ZNF165 drives the unrestrained activation of transforming growth factor β (TGFβ) signalling by directly inactivating the expression of negative feedback pathway regulators, SMURF2, SMAD7 and PMEPA1. | SIGNOR-266095 |
P45983 | P19793 | 1 | phosphorylation | down-regulates activity | 0.464 | Under stress conditions, hyperphosphorylated by activated jnk on ser-56, ser-70, thr-82 and ser-260. These findings indicate that inflammation-mediated cell signaling leads to rapid and profound reductions in nuclear rxralpha levels, via a multistep, jnk-dependent mechanism involving ser260, nuclear export, and proteas... | SIGNOR-145297 |
Q9Y653 | Q14344 | 2 | binding | up-regulates activity | 0.2 | Binding of collagen III to ADGRG1 provides a canonical example of adhesion GPCR interactions with ECM proteins (Luo et al., 2011). Identified by an in vitro biotinylation/proteomics approach, extracellular interactions with collagen III were subsequently proven capable of activating ADGRG1-mediated signaling via Gα12/1... | SIGNOR-272345 |
Q8TD08 | Q15717 | 1 | phosphorylation | down-regulates activity | 0.346 | ERK8 phosphorylates HuR to prevent its binding to PDCD4 mRNA A. ERK8 or control siRNA was transfected into HeLa cells for 48 h followed by treatment of cells with 0.5 mM H2O2 or PBS for 1 h. Cells were fixed and immunofluorescence was performed to monitor HuR localization. | SIGNOR-278314 |
P43657 | Q14344 | 2 | binding | up-regulates activity | 0.353 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257347 |
P45985 | Q9UL54 | 2 | binding | up-regulates activity | 0.259 | Immunoprecipitated psk phosphorylates myelin basic protein and transfected psk stimulates mkk4 and mkk7 and activates the c-jun n-terminal kinase mitogen-activated protein kinase pathway. | SIGNOR-74864 |
Q9BYG3 | P49841 | 0 | phosphorylation | up-regulates activity | 0.2 | The forkhead-associated (FHA) domain of human Ki67 interacts with the human nucleolar protein hNIFK, recognizing a 44-residue fragment, hNIFK226-269, phosphorylated at Thr234. Here we show that high-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer23... | SIGNOR-262698 |
P31749 | P68400 | 0 | phosphorylation | up-regulates | 0.372 | CK2 hyperactivates AKT by phosphorylation at Ser129 | SIGNOR-252595 |
Q9UKX2 | Q06413 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.431 | Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive tra... | SIGNOR-238718 |
Q99570 | Q96F24 | 2 | binding | down-regulates activity | 0.649 | NRBF2 S113 and S120 phosphorylation negatively regulates autophagy. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity. | SIGNOR-265878 |
P68400 | Q13144 | 1 | phosphorylation | up-regulates activity | 0.386 | Two conserved sites (Ser712/713) are phosphorylated by casein kinase 2. They lie at the extreme C-terminus and are required for the interaction of eIF2Bepsilon with its substrate, eIF2, in vivo and for eIF2B activity in vitro. | SIGNOR-250859 |
O95816 | P49137 | 0 | phosphorylation | up-regulates | 0.366 | We provided definite evidence that mapkapk2 phosphorylates bag2 at ser 20 in vitro and in vivo. These results demonstrate that bag2 is a novel component of the p38 mapk signaling pathways. | SIGNOR-126953 |
O95988 | P31749 | 2 | binding | up-regulates | 0.671 | In vivo, tcl1 forms trimers, which associate with akt. Tcl1 facilitates the oligomerization and activation of akt. Our data show that tcl1 is a novel akt kinase coactivator, which promotes akt-induced cell survival and proliferation. | SIGNOR-81713 |
P04040 | P00519 | 0 | phosphorylation | up-regulates activity | 0.403 | C-abl and arg phosphorylated catalase at tyr231 and tyr386 in vitrocatalase is a major effector in the defense of aerobic cells against oxidative stress. Recent studies have shown that catalase activity is stimulated by the c-abl and arg tyrosine kinases | SIGNOR-101302 |
P31749 | P53804 | 2 | phosphorylation | up-regulates | 0.395 | Phosphorylation of ttc3 at ser378 is required for efficient biological function together, these observations support that ttc3 is a phosphorylation target of akt both in an in vitro and in a cellular context | SIGNOR-252508 |
P62993 | Q05397 | 2 | binding | up-regulates activity | 0.706 | Src-mediated phosphorylation of FAK at Tyr925 creates an SH2 binding site for the growth-factor-receptor-bound protein 2 (GRB2) adaptor protein, which leads to the activation of Ras and the extracellular signal-regulated kinase-2 (ERK2) cascade. | SIGNOR-257733 |
O14920 | O43524 | 1 | phosphorylation | down-regulates | 0.692 | Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway | SIGNOR-124207 |
P51531 | Q92922 | 2 | binding | up-regulates | 0.911 | The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added. | SIGNOR-65432 |
Q9NZ94 | P58401 | 2 | binding | up-regulates activity | 0.83 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264157 |
O00141 | O43524 | 1 | phosphorylation | down-regulates activity | 0.794 | We show here that sgk1, like akt, promotes cell survival and that it does so in part by phosphorylating and inactivating fkhrl1. However, sgk and akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on fkhrl1. While both kinases can phosphorylate thr-32, sgk disp... | SIGNOR-236607 |
Q15853 | P49841 | 0 | phosphorylation | up-regulates activity | 0.283 | Although no study has yet correlated the activity of GSK3beta with the activity of USF2 in a certain tumor setting, the findings of the present study would favor the tumor promoting aspects of GSK3beta and USF2 since GSK3beta activated USF2 enhanced cell migration which may be important in terms of tumor cell metastasi... | SIGNOR-278158 |
O15111 | Q5TCX8 | 0 | phosphorylation | down-regulates activity | 0.2 | Immunoprecipitation and in vitro kinase analysis revealed that MLK4 physically interacts with both IKKalpha and beta, but preferentially phosphorylates IKKalpha over IKKbeta (XREF_FIG | SIGNOR-279067 |
P17010 | P09467 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | For instance, nucleophosmin (NPM1) and zinc-finger protein X-linked (ZFX) bind to the E-box and ZFX binding site on the FBP1 promoter, respectively, and restrain FBP1 expression to facilitate aerobic glycolysis in PDAC and melanoma | SIGNOR-267595 |
Q9C0C7 | Q9Y4K3 | 2 | binding | up-regulates activity | 0.588 | In this condition, AMBRA1, interacting with the E3-ligase TRAF6, supports ULK1 ubiquitylation by LYS-63-linked chains, and its subsequent stabilization, self-association and function. | SIGNOR-272963 |
P14416 | P19086 | 2 | binding | up-regulates activity | 0.391 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257096 |
P63096 | Q9NPC1 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256674 |
P01116 | Q07889 | 0 | guanine nucleotide exchange factor | up-regulates | 0.828 | Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts | SIGNOR-141647 |
O14965 | Q13185 | 1 | phosphorylation | up-regulates activity | 0.363 | We report for the first time that during mitotic cell division, heterochromatin protein 1\u03b3 colocalizes and is phosphorylated at serine 83 in G2/M phase by Aurora A. | SIGNOR-280185 |
Q93034 | O95376 | 2 | binding | up-regulates activity | 0.535 | Here, we provide evidence that Ariadne RBR E3 ubiquitin ligases such as TRIAD1 and HHARI can bind and be activated by CRL complexes. Whereas TRIAD1 specifically associates with CUL5–RBX2, HHARI is more promiscuous towards cullin types and associates with RBX1-associated cullins 1, 2, 3, and 4A. Interestingly, both TRIA... | SIGNOR-268843 |
P09936 | P0CG48 | 1 | cleavage | up-regulates quantity | 0.864 | These data suggest that the physiological role of UCH is to hydrolyze small adducts of ubiquitin and to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains | SIGNOR-249693 |
Q15418 | P21333 | 1 | phosphorylation | up-regulates | 0.383 | We show that the n-terminal kinase domain of rsk phosphorylates flna on ser(2152) in response to mitogens | SIGNOR-123458 |
P68431 | O75151 | 0 | demethylation | down-regulates activity | 0.2 | PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an active H3K9Me2 demethylase through PKA-mediated phosphorylation. This modification leads to targeting of the PHF2–ARID5B complex to its target promoters, where it removes the repressive H3K9Me2 mark. | SIGNOR-264521 |
P50148 | Q9NQ66 | 2 | binding | up-regulates | 0.768 | The beta- but not the gamma- and delta-type isozymes of inositol phospholipid-specific phospholipase c (plc) are activated by g protein alpha q and beta gamma subunits. | SIGNOR-37149 |
P40189 | P08887 | 2 | binding | up-regulates | 0.751 | Part of the receptor for interleukin 6. Binds to il6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with il6st. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | SIGNOR-105504 |
P46937 | P49674 | 0 | phosphorylation | down-regulates | 0.422 | Phosphorylation of YAP (S381) and TAZ (S311) by Lats1/2 primes subsequent phosphorylation events by Casein Kinase 1 (CK1d/e); this sequential phosphorylation results in recruitment of b-transducin repeat-containing proteins (b-TRCP; a subunit of the SCF ubiquitin E3 ligase) and consequently leads to degradation of YAP/... | SIGNOR-201170 |
P53611 | P20336 | 1 | lipidation | up-regulates activity | 0.656 | Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this compl... | SIGNOR-265575 |
P23229 | Q01453 | 2 | binding | up-regulates activity | 0.385 | PMP22 is in a complex with α6β4 integrin and laminin. PMP22 and β4 integrin are in a complex in a variety of cell types. The interaction with the integrins provides PMP22 with the ability to modulate the cell–ECM communications, as well as intracellular events. Signaling between the ECM and the intracellular compartmen... | SIGNOR-251895 |
Q15654 | Q9Y4K3 | 2 | binding | up-regulates activity | 0.28 | Our results revealed that TRIP6 could enhance TRAF6 oligomerization and TRAF6 autoubiquitination through its interaction | SIGNOR-280455 |
Q13315 | Q5UIP0 | 2 | binding | up-regulates activity | 0.499 | Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. After induction of double-strand breaks (DSBs), Rif1 formed foci that colocalized with other DNA-damage-response factors. This response was strictly dependent on ATM (ataxia telangiectasia mutated) ... | SIGNOR-259059 |
P28562 | P45983 | 1 | dephosphorylation | down-regulates | 0.789 | Jnk1 phosphorylation and activation was inhibited by expression of both mkp1 and mkp2. | SIGNOR-46079 |
Q04726 | Q96QT6 | 2 | binding | up-regulates activity | 0.2 | We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family m... | SIGNOR-266993 |
P04637 | P14672 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.335 | P53 regulates basal expression of AIF and SCO2 and facilitates oxidative phosphorylation. The expression of GLUT1, GLUT4, and HK2 is negatively regulated by p53, whereas TIGAR expression is induced by p53. The net result of p53-mediated regulation of these glycolytic enzymes is the suppression of glycolysis. In additio... | SIGNOR-267465 |
Q5S007 | Q9UJV3 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. | SIGNOR-278763 |
Q13131 | Q9NRC8 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degradation by REGγ, resulting in the down-regulation of rRNA transcription and cell survival.|These results strongly suggest that the phosphorylation status of SirT7 at T153 plays a cr... | SIGNOR-275864 |
Q12888 | P25440 | 0 | relocalization | up-regulates activity | 0.269 | BRD2 is required to recruit 53BP1 to DSBs.|When BRD2 recruitment was blocked with shRNA or JQ1 (Fig. 3a and Supplementary Figure 3c) or a panel of BRD2 siRNAs (Supplementary Figure 3a), the recruitment of 53BP1 to DSBs was significantly delayed. | SIGNOR-262035 |
Q09472 | P50750 | 0 | phosphorylation | up-regulates activity | 0.376 | As Cdk9 phosphorylates both RNA polymerase II and p300 and increases p300-HAT activity , the effects of CUR and PyrC on the kinase activity of Cdk9 were examined .|As Cdk9 phosphorylates both RNA polymerase II and p300 and increases p300-HAT activity, the effects of CUR and PyrC on the kinase activity of Cdk9 were exam... | SIGNOR-279690 |
P42702 | P27361 | 0 | phosphorylation | down-regulates | 0.299 | Thus, our results identify the human lifr as a substrate for mapk and suggest a mechanism of heterologous receptor regulation of lifr signaling occurring at ser-1044. | SIGNOR-32757 |
Q15139 | Q13563 | 1 | phosphorylation | up-regulates activity | 0.458 | Here, we report the identification of a previously unrecognized phosphorylation site within the polycystin-2 C terminus (Ser801), and we demonstrate that it is phosphorylated by protein kinase D. Phosphorylation at this site was significantly increased in response to serum and epidermal growth factor stimulation.We con... | SIGNOR-259829 |
O95393 | P37023 | 2 | binding | up-regulates | 0.709 | Taken together, our results sug- gest that bmp9 and bmp10 are two spe- cific alk1 ligands that may physiologi- cally trigger the effects of alk1 on angiogenesis | SIGNOR-150201 |
E9PAV3 | P49841 | 0 | phosphorylation | down-regulates | 0.2 | Gsk3 beta-dependent phosphorylation of the alpha nac coactivator regulates its nuclear translocation and proteasome-mediated degradation. | SIGNOR-123262 |
P0DPK5 | Q92830 | 0 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269598 |
P24941 | P33981 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.411 | Cdk2 phosphorylates Mps1 at T468, attenuating the function of a degradation signal found in amino acids 420\u2013507 (encoded by exons 12 and 13) and allowing the accumulation of a centrosomal pool of Mps1 that represents no more than 10% of total cellular Mps1 ( xref ). | SIGNOR-279398 |
P13385 | P27037 | 2 | binding | down-regulates | 0.642 | Here we show that cripto can form a complex with activin and actrii/iib cripto inhibited crosslinking of activin to alk4 and the association of alk4 with actrii/iib. | SIGNOR-100052 |
P08631 | P16885 | 1 | phosphorylation | up-regulates activity | 0.552 | The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated ... | SIGNOR-249364 |
P35613 | Q8NEZ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.427 | F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells | SIGNOR-273452 |
O43638 | P48023 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | As we expected, Fkhl18 suppressed, dose-dependently,human and mouseFasLpromoter in bovine vascularsmooth muscle cells | SIGNOR-261612 |
Q05655 | P12931 | 2 | phosphorylation | up-regulates activity | 0.602 | We conclude that treatment with either UV or PMA induces the phosphorylation of the PKC site Ser12 on c-SRC and that this specific phosphorylation event is significantly diminished in cells overexpressing PR55 | SIGNOR-247974 |
Q15109 | P58753 | 2 | binding | up-regulates activity | 0.41 | These results indicate that TIRAP functions as an essential adaptor protein for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it. | SIGNOR-280459 |
O15530 | O43865 | 1 | phosphorylation | down-regulates activity | 0.2 | Residue 68 resides in a consensus phosphorylation site for PKD (Figure 1A) [22,23]. Interestingly, phosphorylation of Ser68 could allow for subsequent phosphorylation of Ser71, Ser74, Ser77 and Ser80 by CK1, for which the consensus phosphorylation site is pS/T-X-X-S/T| We found that phosphorylation of Ser71 and Ser74 w... | SIGNOR-249174 |
O14746 | P51532 | 2 | binding | up-regulates | 0.776 | Tert activates wnt reporter plasmids in a brg1-dependent manner. | SIGNOR-186607 |
P01106 | P12268 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.294 | Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets. C-MYC depletion did not significantly affect levels of E2F1 protein reported to regulate expression of many S-phase specific genes, but resulted in the repression of several genes encoding enzymes rate-... | SIGNOR-267375 |
P12931 | Q8WUM4 | 1 | phosphorylation | down-regulates activity | 0.393 | Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. Phosphorylation of Alix by Src caused it to translocate from the membrane and cytoskeleton to the cytoplasm and reduced its interaction with binding partners SETA/CIN85, epidermal growth factor receptor, and... | SIGNOR-263201 |
P02545 | P12931 | 0 | phosphorylation | up-regulates activity | 0.51 | In this study, we found that the constitutively active Src Y527F mutant caused the disassembly of lamin A/C. We demonstrate that Src directly phosphorylates lamin A mainly at Tyr45 both in vitro and in intact cells. | SIGNOR-279288 |
Q5GLZ8 | Q99835 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Our data showed that Herc4 mediated Smo degradation by proteasome and lysosome, but mainly by proteasome.|Using the cell based ubiquitination assay, we found that both Myc-SmoK13R and Myc-SmoK49R exhibited reduced ubiquitination compared with Myc-Smo by Herc4, but Myc-SmoK49R resulted in a more dramatic reduction in Sm... | SIGNOR-278521 |
P05771 | Q9Y5S8 | 1 | phosphorylation | up-regulates activity | 0.2 | Site-directed mutagenesis and isothermal titration calorimetry indicated that protein kinase C-beta1 phosphorylates Nox1 at threonine 429. Moreover, Nox1 threonine 429 phosphorylation facilitated the association of Nox1 with the NoxA1 activation domain and was necessary for NADPH oxidase complex assembly | SIGNOR-264729 |
P12931 | Q92945 | 0 | post transcriptional regulation | up-regulates quantity by expression | 0.271 | We show here that this component of the DCS complex is hnRNP H and that, like hnRNP F and KSRP, hnRNP H is needed for src N1 splicing in vitro. | SIGNOR-261274 |
Q14738 | P04049 | 2 | binding | up-regulates activity | 0.449 | ... the PP2A holoenzymes ABC and ABC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade. Furthermore both PP2A holoenzymes were found to associate with Raf1 and catalyze dephosphorylation of inhibitory phospho-Ser-259. | SIGNOR-243420 |
O15550 | P31260 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.267 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260020 |
Q9UFD9 | Q9UQ26 | 2 | binding | down-regulates activity | 0.358 | SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. | SIGNOR-264365 |
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