Datasets:
H2KP
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cdip-annotations-formnet-v1

Dataset card Data Studio Files
xet
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50119548-9557-1.layout.json
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2046807567_7643-9.layout.json
[ "17:20", "202", "637", "1365", "FHILIP", "MORRIS", "CO", "CRS-9", "efforts", "are", "well", "beyond", "the", "resources", "of", "CRS.", "As", "a", "result,", "this", "report", "only", "briefly", "reviews", "the", "current", "state", "of", "knowledge", "about", "those", "other", "topics.", "This", "report", "is", "divided", "into", "four", "chapters.", "The", "first", "chapter", "summarizes", "the", "physical", "and", "chemical", "composition", "of", "ETS,", "and", "the", "evidence", "for", "ETS", "exposure", "and", "uptake", "among", "non-smokers.", "The", "second", "chapter", "examines", "the", "results", "of", "the", "various", "epidemiologic", "studies,", "with", "some", "emphasis", "on", "the", "implications", "of", "the", "dose-response", "trends", "for", "estimating", "the", "lung", "cancer", "risk", "among", "nan-smokers.", "A", "discussion", "of", "confounding,", "smcker", "misclassification,", "and", "recall", "bias", "—", "the", "principal", "sources", "of", "uncertainty", "in", "the", "epi", "studies", "—", "is", "presented", "including", "implications", "for", "the", "dose-response", "cbservations.", "The", "third", "chapter", "discusses", "the", "potential", "iung", "cancer", "death", "risk", "of", "ETS", "including", "the", "consequences", "of", "n", "tpward", "dose-response", "trend.", "This", "chepter", "also", "puts", "the", "potential", "risk", "of", "ETS", "in", "context", "of", "other", "risks", "faced", "by", "the", "general", "population.", "The", "fourth", "chapter", "reviews", "the", "Occupational", "Safety", "and", "Health", "Administration’s", "(OSHA)", "assessmant", "of", "oceupational", "ETS", "lung", "cancer", "risk,", "part", "of", "its", "proposed", "indoor", "air", "quality", "rule.!!", "The", "repert", "also", "includes", "two", "appendices.", "Appendix", "A", "presents", "a", "brief", "overview", "of", "the", "evidence", "linking", "passive", "smoking", "with", "heart", "disesse", "and", "childhood", "respiratary", "illnesses.", "Appendix", "B", "lists", "the", "principal", "ETS", "studies", "reviewed", "for", "this", "report.", "11418,", "Dapt.", "of", "Labor,", "Occupational", "Safety", "ard", "Health", "Administrasion.", "Indoor", "Air", "Quality.", "Notice", "of", "proposed", "rulemaking,", "notice", "of", "informal", "public", "hearing.", "Federal", "Register,", "v.", "59,", "no.", "65,", "April", "5,", "1894", "p.", "15368.", "DRAFT", "SUBJECT", "TO", "REVISION.", "NOT", "FOR", "QUOTATION", "OR", "ATTRIBUTION.", "@010/", "035", "9464089708" ]
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530885130+-5136-5.layout.json
[ "Hong", "Kong:", "Non-Smokers", "More", "Prone", "To", "ETS", "Sickness,", "Study", "Claims", "The", "Journal", "of", "Epidemiology", "and", "Community", "Health", "reported", "that", "5,000", "non-smoking", "Hong", "Kong", "policemen", "who", "were", "exposed", "to", "environmental", "tobacco", "smoke", "(ETS)", "for", "more", "than", "a", "year", "were", "found", "to", "be", "doubly", "likely", "to", "take", "time", "off", "from", "work.", "The", "policemen", "were", "also", "30", "percent", "more", "likely", "to", "be", "affected", "by", "respiratory", "problems,", "compared", "(o", "their", "counterparts", "in", "a", "smoke-free", "environment,", "the", "study", "added.", "The", "rescarchers", "from", "the", "University", "of", "Hong", "Kong", "who", "conducted", "the", "study", "said", "steps", "shoutd", "be", "taken", "to", "ban", "smoking", "at", "all", "workplaces", "(BBC", "Monitoring", "Service", "8/22).", "MIDDLE", "EAST", "AND", "AFRICA", "Egyptian", "Health", "Ministry", "To", "Hire", "Non-", "Smokers", "Only", "Egypt’s", "Health", "Ministry", "issued", "orders", "on", "August", "21%", "that", "only", "non-smokers", "will", "be", "hired", "and", "promoted", "in", "the", "ministry", "as", "part", "of", "the", "country’s", "ongoing", "anti-", "smoking", "campaign.", "The", "director", "of", "the", "ministry’s", "anti-smoking", "program", "Sami", "Ghanem", "said", "the", "Health", "Ministry", "is", "working", "with", "other", "ministries", "to", "educate", "citizens", "about", "alleged", "risks", "of", "smoking.", "According", "to", "a", "ministry", "survey,", "40", "percent", "of", "adult", "males", "and", "cight", "percent", "of", "adult", "females", "in", "the", "country", "smoke", "(AP", "8/22).", "Zimbabwe:", "More", "Farms", "To", "Be", "Seized", "On", "August", "18\",", "President", "Robert", "Mugabe", "listed", "another", "229", "white", "farms", "for", "compulsory", "acquisition", "and", "redistribution,", "bringing", "the", "total", "number", "of", "farms", "to", "be", "seized", "to", "3,270.", "A", "Commercial", "Farmers®", "Union", "spokesman", "said,", "“They", "arc", "clearly", "going", "for", "the", "top", "farms,”", "adding", "that", "the", "seizures", "would", "affect", "the", "economy", "badly.", "Banks", "have", "cut", "off", "loans", "to", "farmers", "out", "of", "concern", "that", "the", "farmers", "may", "not", "continue", "to", "own", "their", "land", "and", "harvest", "crops.", "Meanwhile,", "some", "white", "farmers", "started", "working", "on", "tobacco", "fields", "cautiously", "this", "week", "1o", "prepare", "for", "the", "next", "season,", "as", "the", "tobacco", "crop", "must", "be", "planted", "by", "carly", "September.", "“Last", "weck", "was", "a", "decision", "week", "for", "us,”", "said", "one", "farmer,", "Many", "farmers", "are", "still", "not", "sure", "if", "their", "farms", "will", "be", "seized", "(Telegraph", "—", "India", "8/19,", "Business", "Day", "8/22).", "Uganda:", "Officials", "Want", "Focus", "On", "Leaf", "Quality", "Uganda", "is", "estimated", "to", "produce", "24,000", "MT", "of", "lcaf", "in", "2000,", "an", "amount", "that", "industry", "officials", "claim", "can", "be", "doubled", "in", "a", "short", "time", "if", "market", "conditions", "permit", "it.", "However,", "officials", "believe", "the", "country", "will", "not", "benefit", "from", "a", "60,000", "MT", "leaf", "shortfall", "expeccted", "in", "Zimbabwe.", "Zimbabwe", "can", "produce", "220,000", "MT", "of", "leaf", "annually,", "but", "production", "has", "been", "low", "due", "to", "recent", "farm", "invasions.", "Patrick", "Rose,", "British", "American", "Tobacco’s", "leaf", "manager", "for", "caslern", "Africa,", "said", "although", "there", "is", "a", "great", "potential", "to", "grow", "tobacco", "in", "Uganda,", "the", "world", "market", "is", "in", "a", "slump", "duc", "to", "a", "“general", "anti-smoking", "sentiment.”", "Mr,", "Rose", "said", "Ugandan", "exports", "are", "susceplible", "to", "international", "prices,", "as", "the", "domestic", "consumption", "is", "only", "4", "percent", "of", "its", "production,", "Given", "the", "scenario,", "it", "is", "more", "practical", "to", "focus", "on", "quality", "rather", "than", "volumes,", "said", "another", "official", "(Business", "Day", "8/18).", "WESTERN", "HEMISPHERE", "Dominican", "Republic:", "Planting", "Restricted", "To", "Farmers", "With", "Contracts", "The", "new", "Agriculture", "Secrctary", "of", "the", "Dominican", "Republic", "Eligio", "Jaguez", "announced", "that", "only", "those", "tobacco", "growers", "with", "existing", "supply", "contracts", "will", "be", "allowed", "to", "plant", "tobacco", "this", "season.", "The", "decision", "is", "reportedly", "an", "attempt", "(0", "prevent", "overproduction,", "which", "is", "believed", "to", "have", "affected", "leaf", "quality", "and", "prices.", "He", "stated", "that", "a", "sufficient", "amount", "of", "tobacco", "leaf", "is", "stored", "locally", "right", "now", "to", "satisfy", "local", "demand", "for", "cigar", "production", "over", "the", "next", "five", "years.", "Mr.", "Jaques", "reported", "that", "the", "tobacco-growing", "arca", "in", "the", "country", "is", "currently", "over", "300,000", "hectares", "[El", "Siglo", "8/18].", "6", "“4Z5¥%", "P.0.", "Box", "8019,", "Princeton,", "N.J.", "08543;", "609-275-4900;", "609-275-8379", "(fax);", "tma@tma.org", "WAO00-34", "RJR0000001145023422", "70080", "0030768", "S€LS", "880¢es" ]
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513839252_513839291-24.layout.json
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521826392+-6403-0.layout.json
[ "it", "Genetic", "Toxicology", "ELSEVIER", "Mutation", "Research", "342", "(1995)", "179-190", "A", "comparison", "of", "the", "mutagenicity", "of", "mainstream", "cigarette", "smoke", "condensates", "from", "a", "representative", "sample", "of", "the", "U.S.", "cigarette", "market", "with", "a", "Kentucky", "reference", "cigarette", "(K1R4F)", "*", "Rhenda", "H.", "Steele", "**,", "Victoria", "M.", "Payne", "®,", "Cynthia", "W.", "Fulp", "®,", "D.", "Cooper", "Rees", "°,", "Chin", "K.", "Lee", "®,", "David", "J.", "Doolittle", "®", "*", "RJ.", "Reynolds", "Tobacco", "Company,", "Bowman", "Gray", "Technical", "Center,", "P.O.", "Box", "1487,", "Winston-Salem,", "NC", "27102-1487,", "USA", "RJ.", "Reynolds", "Tobacco", "Company,", "Bowman", "Gray", "Technical", "Center,", "P.O.", "Box", "2959,", "Winston-Salem,", "NC", "27102-2959,", "USA", "Received", "13", "July", "1994;", "revised", "9", "November", "1994;", "accepted", "§", "December", "1994", "Abstract", "The", "Salmonella", "mutagenicity", "assay", "has", "been", "used", "to", "investigate", "the", "mutagenicity", "of", "cigarette", "smoke", "and", "cigarette", "smoke", "condensate.", "The", "Kentucky", "reference", "(K1R4F)", "cigarette", "is", "designed", "to", "be", "representative", "of", "fuli-flavor,", "low-tar", "cigarettes", "sold", "in", "the", "U.S.", "and", "to", "serve", "as", "a", "reference", "standard", "for", "comparative", "studies", "on", "the", "chemistry", "and", "biological", "activities", "of", "cigarette", "smoke", "and", "condensate.", "The", "objective", "of", "this", "study", "was", "to", "determine", "if", "the", "mutagenicity", "of", "mainstream", "smoke", "condensate", "from", "the", "KIR4F,", "as", "measured", "by", "the", "Salmonella", "mutagenicity", "assay,", "is", "representative", "of", "the", "mutagenic", "activity", "of", "U.S.", "cigarettes.", "Mainstream", "smoke", "condensates", "prepared", "in", "dimethyl", "sulfoxide", "from", "the", "KIR4F", "and", "73", "brand", "styles", "(representing", "greater", "than", "70%", "of", "the", "total", "U.S.", "cigarette", "market)", "were", "assayed", "using", "Salmonella", "typhimurium", "TA98", "and", "TA100", "(+S9)", "at", "concentrations", "of", "0,", "25,", "50,", "75,", "100,", "125", "and", "250", "pg/plate.", "Revertants/mg", "condensate", "were", "determined", "by", "calculating", "the", "slopes", "of", "the", "dose-response", "curves", "using", "linear", "and", "nonlinear", "regression", "models.", "Revertants/cigarette", "were", "determined", "by", "multiplying", "the", "revertants/mg", "condensate", "by", "the", "mg", "condensate/cigarette.", "No", "significant", "differences", "(p", ">", "0.05)", "were", "observed", "between", "the", "mean", "mutagenicity", "of", "U.S.", "market", "and", "KIR4F", "mainstream", "smoke", "condensates", "in", "terms", "of", "revertants/mg", "condensate", "or", "revertants/cigarette.", "Increased", "variability", "in", "mutagenicity", "was.observed", "among", "the", "U.S.", "brands", "versus", "that", "of", "the", "K1R4F.", "This", "is", "not", "surprising", "since", "variability", "among", "the", "U.S.", "brands", "would", "be", "expected", "to", "have", "both", "measurement", "error", "and", "brand", "style", "variability", "while", "the", "K1R4F", "variability", "contains", "only", "the", "measurement", "error", "portion.", "These", "results", "demonstrate", "that", "the", "KIR4F", "is", "a", "representative", "model", "for", "the", "U.S.", "cigarette", "market", "in", ".", "comparative", "Salmonella", "mutagenicity", "studies", "using", "mainstream", "smoke", "condensates.", "*", "Presented", "in", "part", "at", "the", "30\"", "Annual", "Meeting", "of", "the", "Society", "of", "Toxicology,", "Dallas,", "Texas,", "1991,", "\"", "Corresponding", "author.", "Address:", "R.J.", "Reynolds", "Tobacco", "Company,", "Bowman", "Gray", "Technical", "Center,", "P.O.", "Box", "1487,", "Winston-", "Salem,", "NC", "27102-1487.", "Tel.:", "(910)", "741-4374;", "Fax:", "(910)", "741-0815.", "0165-1218,/95", "/509.50", "©", "1995", "Elsevier", "Science", "B.V.", "All", "rights", "reserved", "SSDI", "0165-1218(94)00091-3", "Z6E9", "Z8TZS" ]
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524860047+-0116-40.layout.json
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tob08513.09.layout.json
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2062199166.layout.json
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2046807567_7643-42.layout.json
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531376115+-6129-0.layout.json
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2064814997_4998-0.layout.json
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2020226017_6019-1.layout.json
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"tean", "sittenkin", "pinaattipedille", "ja", "3", "Libaruokien", "vkkonen", "on", "wmpuilainen", "{42", "mk)", "jota", "tpasag", "G", "SN", "Adam", "Korpak", "nuori", "nainen", "naapuripdyddssi", "myshemmin", "syé", "antaumuksel-", "L.", "Jogurttimarinoidun", "tandoo-", "rikanan", "tilas", "ulkomainen", "naa-", "puri", "toisella", "puoleq.", "Puhdasta", "amerikkaa", "puhuva", "mies", "farkuissaan", "valitsee", "kyl-", "misavulohipastan,", "Kukaan", "¢i", "juuri", "nyt", "sy", "nu-", "mera", "viitosta:", "Coner", "(=", "coeur)", "de", "Filet", "Finlandaise", "(35", "mk),", "joka", "on", "kuulemmma", "kysytiyd", "ta-", "vuraa:", "puolikas", "HK:n", "sinisti", "MAKUASTA", "Chez", "Richard", "lenkkia,", "Kalleimmat", "annokset", "ovat", "lampaankare", "{=", "karce)", "ja", "vi-", "herpippurijunstolla", "tdytetty", "hi-", "ranfile(e)pihvi", "(92-96", "mk).", "Kielitoimisto", "ei", "hyviksy", "filett;", "emmehiin", "me", "puhu", "foffesta-", "kaan,", "vaan", "toffeesta.", "File-muo-", "to", "on", "vahvassa", "nousussa.", "Jopa", "Voi", "hyvin", "kiydd", "niin,", "ettd", "vai", "1", "muoto", "ajan", "mittaan", "voittaa.", "R", "ichard'sissa", "on", "hauskan", "rennosti", "pukeutuneita", "michiz,", "jotka", "osaavat", "epiiile-", "miittii", "tarvittaessa", "valita", "krava-", "tinkin.", "Sopivasti", "kaikkia", "vuosi-", "kertoja.", "Péytiscurueet", "Keskus-", "televat", "vilkkaasti,", "mutta", "kun", "ruoka", "tulee", "eteen,", "sen", "Kimp-", "Aloitamme", "tysti.", "Kanarulla", "mango-avo", "dokastikkeelia", "on", "miellyttivin", "kevyt", "ja", "selked,", "samoin", "graavi", "maistelun", "bl", "sitka,", "joka", "on", "juuri", "niin", "hyvaa", "{ei", "suolaista)", "kuin", "tuorcen", "raa’an", "kalan", "pitdikin", "oHla.", "Limmin", "peruna", "ja", "sienimuhen-", "nos", "ei", "sitd", "vastoin", "ole", "parhain", "seuralainen,", "eikd", "salaattisilppu-", "kaan", "oikein", "jisenny.", "Yhdistel-", "min", "voisi", "ajatella", "yksinkertai-", "japanilaisittain.", "MNuoret", "kokit", "askartelevat", "osin", "ni#kyvilld,", "ja", "se", "on", "muka-", "vaa.", "He", "kantavat", "myds", "pSytain", "komeasti", ";", "aseteltuja", "annoksia", "reunoja", "lautasilla.", "Olin", "‘ihan", "unobtanut", "luontopolut", ".", "sirotelltsta", "paprikasta,", "persiljasilpusta,", "p-", "lysokerista.", "sytikumppani", "raksuttelee", "hyvidnmakuisia", "mériravun-", "pyTstijs;", "risii", "on", "_enemmin", "kuin", "riittiiviisti,", "Puraisen", "ensim-", "maiista", "i", "kolmesta", ";'", "kultaiseksi", "paistetusta’ahvenfileestd.", "Kylia", "Ton", "-hyval,", "-kevyesti", "sopivia.", "Mutia", "pinaattipeti", "on", "kuin", "vaa-", "lea", "mitids;", "johon", "tuulenpuuska", "on", "‘tuomut", "mmutamia", "vihreitd", "vappuhuiskansuikaleita", ".", ".", ".", "ei", "pahan", "makuista", "sindnsi.", "\"Kysy", "pdivin", "jilkinokia", "2", "28", "mk\",", "listalla", "sanotaan.", "Tuorest", "kiivihedelmiit", "lmpdisen", "zabag-", "tione-kastikkeen", "kanssa", "pienen", "melonisorbettipallon", "kruunaa-", "mina", "on", "kyld", "28", "markan", "vaér-", "ti!", "Espresso-kahvikin", "maistun.", "Kyllipi", "oli", "byvi", "tdea", "tulla", "kui-", "malle!", ".", "Tuija", "Verkkola", "P.S.", "Kivipiira", "on", "lintujen", "k-", "hasmaha", "eli", "mahalaukun", "vii-", "meinen", "pussimainen", "osa,", "jossa", "jyvat", "hienontuvat", "siind", "esiinty-", "vien", "pienten", "kivien", "ansiosta.", "Ranskassa", "titi", "\"kéyhin", "kan-", "san”", "herkkua", "syddiin", "ecdel-", "leen,", "Richard'siin", "sitd", "tulevat-", "kin", "sysmi4n", "juuri", "Ranskan-ka-", "vijiit.", "\"Aika", "iso,", "broilerissakin", "munan", "kokoinen™,", "kerrotaan", "tiedonhaluiselle.", "Rickard’s", "Rikhardinkatu", "4,", "puh.", "865", "884", "Avoinna;", "mu-pe", "lounas", "kie", "{1-13", "ma-ke", "kiv", "18-24,", "g", "ko", "18-,", "fa", "ki", "1502", "&", "+r", "0002590", "i", "3", "i" ]
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2046807567_7643-17.layout.json
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521513430+-3444-12.layout.json
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2046807567_7643-10.layout.json
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2046807567_7643-16.layout.json
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0001039501-0.layout.json
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10427748.layout.json
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504221516_504221531-0.layout.json
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0001039501-129.layout.json
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0001039501-74.layout.json
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2071327810_7819-4.layout.json
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500692166_500692218-46.layout.json
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524860047+-0116-6.layout.json
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11300117-0136-14.layout.json
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524860047+-0116-20.layout.json
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509790579+-0598-15.layout.json
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2022161585_2022161648-18.layout.json
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502251729_502251756-22.layout.json
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2028471090_2028471104-2.layout.json
[ "RESULTS", "A.", "Carcinogenicity", "Benzene", "is", "recognized", "as", "being", "carcinogenic", "by", "the", "governments", "of", "Finland,", "the", "Federal", "Republic", "of", "Germany,", "Italy,", "Japan,", "Sweden,", "Switzerland", "and", "the", "U.S.A.", "(IARC,", "1988).", "The", "first", "case", "report", "suggesting", "an", "association", "between", "exposure", "to", "1928", "benzene", "and", "leukaemia", "was", "given", "by", "Delore", "and", "Borgomano.", "An", "acute", "lymfoblastic", "leukaemia", "was", "observed", "in", "a", "worker", "in", "France,", "who", "uas", "exposed", "to", "benzene", "for", "five", "years.", "1976,", "Vigliani", "estimated", "the", "increase", "in", "risk", "of", "leukaemia", "to", "be", "20-fold", "for", "workers", "exposed", "to", "benzene", "in", "shoe", "factories", "in", "Iitaly.", "1981", "Among", "workers,", "exposed", "to", "benzene", "during", "the", "manufacture", "of", "rubber", "hydrochloride,", "for", "more", "then", "S", "years,", "5", "had", "died", "from", "leukaemia,", "compared", "to", "0.23", "expected,", "indicating", "a", "21-fold", "increase", "in", "risk.", "U.S.", "MIOSH", "(Rinsky", "et", "al.).", "1982", "The", "assessment", "indicates", "that", "a", "working", "life", "time", "exposure", "to", "benzene", "at", "an", "exposure", "level", "of", "10ppm", "poses", "a", "substantial", "excess", "risk", "of", "death", "from", "leukaemia.", "U.S.", "OSHA", "(White", "et", "al.).", "1982", "\"It", "is", "established", "that", "human", "exposure", "to", "commercial", "benzene", "or", "benzene~containing", "mixtures", "can", "cause", "damage", "to", "the", "haematopoietic", "system,", "including", "pancytopenia.", "The", "relationship", "betueen", "benzene", "exposure", ".", ".", "..,", "and’", "the", "development", "of", "acute", "myelogenous", "leukaemia", "has", "been", "established", "in", "=", "epidemiological", "studies.", "\"Reports.", "Yinking", "exposure", "to", "benzene", "with", "other", "malignancies", "uwere", "considered", "to", "be", "inadequate", "for", "evaluation.", "\"There", "is", "sufficient", "evidence", "that", "benzene", "is", "carcinogeniC", "%0", "man", "(LARCY", ".", "1983", "Benzene", "exposure", "may", "cause", "multiple", "myeloma", "in", "humans.", "(Decoutfle", "et", "al.", "1983", "&", "Rinsky", "et", "al.", "1985).", "1987", "Substantial", "decrease", "in", "the", "risk", "for", "death", "from", "leukaemia", "could", "be", "achieved", "by", "louwering", "occupational", "exposure", "to", "benzene,", "including", "NTOSH", "importantly)", "exposure", "within", "the", "range", "10ppm", "O.", "ippm.", "U.S.", "(Rinsky", "et", "al.).", "B.", "Genotoxicity", "is", "a", "clear", "corelation", "betuween", "exposure", "to", "benzene", "and", "the", "in", "the", "bone", "marrow", "and", "peripheral", "(>100ppm).", "1982", "\"There", "appearance", "of", "chromosomal", "aberations", "lymphocytes", "of", "individuals", "exposed", "to", "high", "levels", "of", "benzene", "Such", "levels", "of", "exposure", "usually", "lead", "to", "clinical", "symptoms", "of", "benzene-induced", "blood", "dyscrasias.", "These", "aberrations", "may", "persist", "for", "many", "years", "after", "exposure", "and", "after", "manifestations", "of", "haematotoxicity...", "2", "2601218202", "v" ]
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500441172+-1192-2.layout.json
[ "DORAL", "\"MAGICIAN\"", "PRINT", "PRE-TEST", "SUMMARY", "BACKGROUND:", "The", "DORAL", "\"Magician\"", "print", "ad", "pre-test", "was", "conducted", "in", "LOOK", "magazine", "December", "1,", "1970", "issue.", "The", "objectives", "of", "the", "pre~test", "were", "to", "deter-", "mine", "the", "communicative", "and", "attention-getting", "ability", "of", "the", "Brand's", "1971", "cartoon", "creative", "executions.", "The", "test", "was", "requested", "due", "to", "the", "Brand's", "concerns", "regarding", "the", "ability", "of", "the", "format", "to", "communicate", "DORAL's", "major", "copy", "points", "without", "endangering", "the", "Brand's", "image.", "SUMMARY", ":", "\"Magician\"", "achieved", "a", "total", "recall", "of", "15%.", "The", "ad", "had", "7%", "specific", "recall", "and", "8%", "general", "recall.", "Unduplicated", "\"taste\"", "and", "\"low", "tar", "and", "nicotine\",", "the", "Brand's", "primary", "copy", "points", "were", "recalled", "by", "7%", "and", "4%", "respectively.", "Situation", "recall", "was", "6%", "and", "slogan", "(\"Taste", "Me\")", "recall", "was", "6%.", "Due", "to", "concerns", "of", "the", "Brand,", "information", "other", "than", "normal", "recall", "test", "data", "was", "obtained.", "Attitudinally,", "20%", "rendered", "favorable", "comments", "and", "1%", "rendered", "unfavorable", "comments.", "A", "total", "of", "12%", "considered", "the", "execution", "to", "be", "humorous", "or", "cute,", "9%", "liked", "the", "cartoons", "and", "8%", "found", "the", "executions", "to", "be", "eye-catching.", "A", "total", "of", "4%", "thought", "the", "ad", "was", "silly", "or", "childish.", "Respondents", "indicated", "that", "the", "ad", "was", "interesting", "(75%", "vs.", "25%),", "not", "insulting", "(87%", "vs.", "13%),", "and", "not", "boring", "(81%", "vs.", "19%).", "There", "was", "no", "significant", "difference", "regarding", "the", "informative", "aspects", "of", "the", "ad", "or", "whether", "or", "not", "it", "was", "funny.", "Demographically,", "\"Magician\"", "was", "recalled", "equally", "among", "men", "and", "women,", "better", "by", "those", "under", "35", "and", "over", "50,", "and", "better", "by", "high", "school", "graduates.", "CONCLUSIONS", ":", "\"Magician\"", "was", "successful", "in", "achieving", "a", "high", "degree", "of", "attention", "and", "readership", "as", "it", "registered", "a", "total", "recall", "of", "15%", "versus", "the", "Company", "average", "of", "8%.", "The", "ad", "was", "also", "relatively", "successful", "in", "communicating", "the", "Brand's", "\"good", "taste\"", "copy", "point,", "but", "failed", "to", "properly", "convey", "the", "Brand's", "other", "primary", "sales", "message", "of", "low", "\"tar\"", "and", "nicotine.", "\"Magician\"", "communicated", "the", "copy", "points", "better", "than", "other", "print", "efforts.", "The", "ad", "was", "well", "received", "by", "the", "readers", "and", "apparently", "had", "no", "adverse", "effect", "on", "the", "Brand's", "image", "as", "favorable", "comments", "outweighed", "unfavorable", "comments", "by", "20", "to", "1", "and", "only", "4%", "fouhd", "the", "ad", "to", "be", "\"childish\"", "or", "\"silly\",", "Readers", "also", "found", "the", "ad", "to", "be", "interesting", "and", "did", "not", "consider", "it", "insulting", "or", "boring.", "The", "Brand", "is", "concerned", "that", "13%", "of", "those", "who", "recalled", "the", "ad", "felt", "it", "was", "insulting.", "However,", "the", "Magician", "\"insulting\"", "percentage", "is", "considerably", "less", "than", "the", "average", "for", "other", "MRD", "tests", "in", "which", "attitudinal", "questions", "were", "asked.", "The", "ad", "was", "successful", "in", "reaching", "equal", "portions", "of", "men", "and", "women.", "However,", "it", "was", "not", "best", "received", "among", "the", "35", "50", "age", "group", "and", "the", "college", "cducated", "consumers", "who", "demographically", "represent", "the", "market", "segment", "of", "greatest", "potential", "for", "the", "Brand.", "gLl", "8udds" ]
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2031536180_2031536183-1.layout.json
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508939370_508939517-12.layout.json
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500692166_500692218-7.layout.json
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0011573077-2.layout.json
[ "!", "i", "1", "THE", "CIGARETTE", "MABIT-FORD", "&", "EDERER", "141", "many", "pharmacological", "preperties", "with", "nicotine", "and", "has", "been", "used", "widely", "s", "a", "nicotine", "substitute", "during", "the", "“withdrawal”", "af", "cigarettes.", "A", "number", "of", "con-", "trolled", "clinical", "trials", "bave", "been", "performed", "to", "evalu-", "ate", "the", "effectiveness", "of", "lobeline.", "In", "at", "least", "six", "studies,", "lobeline", "proved", "to", "be", "no", "more", "effective", "than", "the", "placebo.", "One", "of", "the", "most", "carefully", "designed", "was", "a", "double-blind", "trial", "spen-", "sored", "by", "the", "British", "Tuberculosis", "Associstion.”", "Patients", "from", "11", "chest", "clinics", "who", "smoked", "at", "least", "20", "cigarettes", "daily", "and", "expressed", "a", "desire", "ta", "stop", "smoking", "in", "a", "six-week", "smaking", "deterrent", "study.", "Eighty-one", "patients", "were", "supplied", "with", "tah.", "lets", "containing", "a", "buffered", "lobeline", "preparation", "or", "with", "identical", "placebo", "tablets.", "During", "the", "course", "of", "the", "tral,", "10%", "of", "the", "patients", "ceased", "smoking,", "there", "was", "no", "diflerence", "between", "the", "lobeline", "and", "placebo", "groups.", "The", "duration", "of", "this", "trial,", "its", "double-blind", "design,", "and", "the", "fact", "that", "the", "patients", "had", "diseases", "in", "which", "smoking", "was", "contrain-", "dicated", "and", "had", "expressed", "a", "desire", "to", "stop", "are", "fac-", "tors", "which", "lend", "support", "to", "the", "negative", "conclusion", "s", "to", "the", "usefulness", "of", "lobeline.", "None", "of", "the", "clinical.", "trials", "mentioned", "above", "demonstrated", "a", "significant", "difference", "between", "lobe-", "Line", "and", "the", "placebo.", "On", "the", "otber", "hand,", "several", "other", "double-blind", "studies", "have", "found", "that", "lobeline", "preparations", "were", "significantly", "more", "effective", "than", "the", "placebo.", "Perlstein’®", "found", "that", "after", "four", "weeks", "of", "treatment,", "27%", "of", "the", "patients", "receiving", "lobeline", "discontinued", "smoking,", "while", "none", "of", "the", "patients", "receiving", "the", "placeba", "stapped", "smoking.", "In", "this", "privately", "published", "report,", "it", "is", "stated", "that", "the", "45", "patients", "receiving", "lobeline", "and", "the", "32", "patients", "re-", "ceiving", "the", "placebo", "were", "matched", "for", "sge,", "sex,", "cigarette", "consumption,", "and", "duration", "of", "smoking", "habits,", "but", "&", "complete", "description", "of", "the", "trial", "was", "nat", "presented.", "London'", "reported", "on", "a", "double-blind", "trial", "of", "Iobeline", "in", "74", "subjects", "who", "expressed", "a", "desire", "to", "curb", "their", "smoking", "habits.", "After", "four", "weeks", "of", "therapy,", "12%", "of", "the", "lobéline-treated", "group", "and", "none", "of", "the", "placebo", "group", "had", "stopped", "smoking.", ".", "The", "number", "of", "cigarettes", "smoked", "was", "reduced", "to", "half", "or", "less", "in", "an", "additional", "57%", "of", "the", "lobcline", "zioup", "and", "12.5%", "of", "the", "placebo", "group.", "A", "minor", "problem", "which", "complicates", "the", "interpretation", "of", "this", "study", "is", "that", "oropharyngeal", "discomfort", "was", "noted", "in", "half", "of", "the", "lobeline", "group,", "and", "this", "might", "have", "“unblinded”", "the", "trial", "to", "that", "extent.", "While", "problems", "in", "experimental", "design", "detract", "from", "a", "few", "of", "the", "studies,", "it", "is", "apparent", "that", "the", "majority", "of", "controlled", "studies", "have", "not", "demon-", "strated", "that", "lobeline", "is", "superior", "to", "&", "placebo.", "Nev-", "ertheless,", "a", "few", "double-blind", "studies", "bave", "indicated", "that", "the", "drug", "is", "significantly", "effectiva.", "In", "general,", "the", "dosage", "and", "formulation", "of", "the", "lobeline", "prepara-", "tians", "were", "similar", "in", "the", "negative", "and", "affirraative", "studies.", "However,", "the", "subjects,", "the", "physicians,", "and", "the", "circumstances", "of", "the", "trisle", "did", "differ", "from", "study", "to", "study.", "One", "must", "conclude", "that,", "while", "lobeline", "is", "nat", "strikingly", "effective", "in", "reducing", "ciga-", "JAMA,", "Oct", "11,", "1965", "»", "Val", "194,", "No", "2", "rette", "consumption,", "it", "may", "be", "of", "henefit", "in", "a", "smok-", "ing", "deterrent", "progran", "with", "certain", "subjects", "and", "under", "certain", "circumstances.", "Smaking", "Treatment", "Clinics", "The", "individual", "treatment", "modalities", "reviewed", "have", "not", "been", "notably", "effective", "in", "terminating", "the", "cigarette", "habit.", "There", "has", "been", "a", "tendency", "to", "tom-", "bine", "these", "treatment", "methods", "in", "most", "smoking", "treatment", "clinics.", "Typical", "programs", "last", "from", "ten", "days", "to", "six", "weeks", "and", "employ", "educational", "ap-", "proaches,", "various", "psychalogical", "techniques,", "diets,", "exercises,", "tranquilizers,", "anticholinergics,", "lobeline,", "or", "other", "measures,", "These", "clinics", "have", "been", "operating", "in", "the", "Scandipavian", "countries", "since", "about", "1958", "and", "also", "have", "been", "established", "in", "Canada,", "Great", "Britain,", "and", "other", "European", "countries.", "Similar", "clinics", "have", "been", "established", "in", "this", "country", "under", "the", "sponsorship", "of", "religious", "ordars,", "municipalities,", "foundations,", "and", "health", "agencies.", "In", "a", "few", "instances,", "the", "eflectiveness", "of", "these", "clinics", "has", "been", "evaluated.", ".", "Of", "the", "1,012", "cigarette", "smokers", "who", "attended", "the", "“gntismoking", "clinics”", "in", "Stockbiolm,", "76%", "of", "those", "who", "completed", "the", "ten-day", "course", "of", "ireatment", "said", "they", "had", "stopped", "smoking", "completely,", "and", "an", "additional", "22%", "reduced", "their", "consumption", "to", "less", "than", "a", "quarter", "of", "the", "number", "of", "cigarettes", "smaked", "before", "However,", "a", "subsequent", "publi-", "cation'", "has", "disclosed", "that", "at", "the", "time", "of", "follow--", "up,", "six", "months", "after", "treatment,", "only", "23%", "st", "were", "abstaining", "from", "smoking", "cigarettes,", "and", "ax-", "additional", "§%", "atill", "were", "smoiting", "less", "than", "25%", "of", "their", "previous", "consumptien.", "Several", "smoking", "treatment", "clinics", "in", "this", "coun-", "try", "and", "in", "Europe", "are", "attempting", "to", "develop", "more", "effective", "methads;", "thus", "far,", "no", "improvement", "over", "the", "results", "described", "above", "has", "been", "reported.", "Causes", "of", "Relapse", "High", "relapse", "rates", "have", "been", "&", "recument", "prob-", "lem", "in", "ail", "clinies", "which", "bave", "analyzéd", "their", "lovg-", "term", "results.", "As", "many", "as", "balt", "of", "the", "‘pecple", "wha", "complete", "the", "course", "of", "treatment", "in", "smoking", "elinics", "have", "been", "found", "to", "resume", "cigarette", "smoking", "with-", "«", "in", "six", "months", "®", "Several", "factors", "which", "influence", "relapse", "raves", "have", "been", "identified.", "In", "most", "studies,", "the", "1elapse", "1ates", "have", "been", "greatest", "among", "those", "who", "merely", "reduced", "the", "number", "of", "cigareites", "smoked", "and", "least", "among", "those", "wha", "ceased", "smok-", "ing", "entirely.", "For", "cxample,", "Lynch®", "found", "that", "fe-", "lapse", "occurred", "within", "three", "months", "in", "50%", "of", "per-", "sons", "who", "reduced", "the", "amount", "of", "smeking", "or", "who", "changed", "o", "cigsrs", "ot", "a", "pipe,", "but", "only", "in", "8%", "of", "those", "who", "completely", "stopped", "smoking.", "Hammond", "and", "Garfinkel'", "observed", "a", "similar", "situation", "among", "men", "who", "were", "questioned", "about", "their", "smoking", "habits", "in", "1959", "and", "1960", "2nd", "again", "{wo", "years", "later.", "He", "found", "that", "among", "ex-cigarette-swokars", "who", "were", "ot", "using", "any", "form", "of", "tobacco", "at", "the", "time", "of", "the", "first", "questionnaire,", "only", "9%", "had", "resumed", "smok-", "ing", "cigarettes", "during", "the", "fellowing", "two", "years.", "By", "comparisan,", "persons", "who", "had", "switched", "from", "ciga-", "1", "6582822861", "—", "m———" ]
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518415175+-5177-1.layout.json
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2505614318.layout.json
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2071327810_7819-9.layout.json
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80228906_80228935-25.layout.json
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2063251497_1502-4.layout.json
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531376115+-6129-10.layout.json
[ "News", "Report", "May", "6,", "1997", "“*Being", "elderly", "is", "not", "a", "health", "problem,’”", "he", "said", "last", "week.", "**But", "once", "you", "have", "achieved", "survival,", "you", "would", "like", "to", "improve", "quality", "of", "life.’”’", "Source:", "Herald", "Washington", "Bureau", "By", "Shankar", "Vedantam", "PLAINTIFFS", "OFFER", "NEW", "LIABILITY", "PLAN", "In", "talks", "in", "Dallas", "with", "cigarette", "producers,", "state", "attorneys-general", "offered", "a", "plan", "on", "Monday", "that", "would", "give", "full", "legal", "rights", "to", "smokers", "suing", "tobacco", "companies", "but", "would", "limit", "the", "amount", "of", "money", "the", "industry", "would", "have", "to", "pay", "out", "annually,", "said", "a", "person", "close", "to", "the", "talks.", "The", "new", "liability", "plan,", "developed", "over", "the", "past", "week,", "represents", "a", "hardening", "of", "the", "position", "taken", "by", "state", "regulators.", "In", "settlement", "talks", "with", "the", "industry", "last", "month,", "state", "officials", "had", "agreed", "to", "consider", "limiting", "the", "amount", "of", "money", "any", "smoker", "could", "recover.", "“We", "think", "this", "is", "fairer", "from", "a", "public", "policy", "standpoint,”", "said", "the", "person", "familiar", "with", "the", "negotiations", "who", "requested", "anonymity.", "The", "proposal", "would", "address", "the", "cigarette", "industry’s", "desire", "for", "financial", "predictability.", "The", "industry’s", "obligation", "to", "make", "annual", "payments", "under", "the", "plan", "could", "extend", "for", "25", "years.", "Details", "of", "the", "new", "proposal", "are", "still", "in", "flux", "but", "it", "might", "work", "in", "several", "ways,", "said", "people", "familiar", "with", "it.", "If", "a", "smoker", "succeeded", "in", "winning", "a", "claim", "against", "a", "company,", "that", "person", "might", "not", "be", "able", "to", "collect", "for", "a", "while", "if", "that", "year’s", "pool", "of", "money", "was", "already", "exhausted", "by", "smokers", "who", "had", "filed", "their", "claims", "earlier.", "Alternatively,", "smokers", "who", "succeeded", "in", "one", "year", "may", "receive", "part", "of", "their", "award", "that", "year", "and", "the", "rest", "later.", "Spokesmen", "for", "the", "Philip", "Mortis", "Cos.", "and", "the", "RJR", "Nabsico", "Corp.,", "the", "two", "tobacco", "giants", "who", "are", "actively", "participating", "in", "the", "talks,", "have", "declined", "to", "comment", "on", "any", "aspect", "of", "the", "negotiations.", "Cigarette", "producers,", "who", "have", "dropped", "their", "previous", "demand", "for", "complete", "legal", "protection,", "are", "expected", "to", "counter", "with", "proposals", "to", "cap", "how", "much", "could", "be", "awarded", "to", "individual", "plaintiffs", "in", "any", "one", "lawsuit", "or", "make", "it", "more", "difficult", "to", "win", "in", "court,", "said", "the", "person", "close", "to", "the", "talks.", "Source:", "New", "York", "Times:May", "6,", "1997", "By", "Barry", "Meier", "PRO-ToBACCO", "VERDICT", "COULD", "FIRE", "UP", "NEGOTIATIONS", "FOR", "LIABILITY", "SETTLEMENT", "The", "verdict", "in", "a", "much-watched", "smoker’s", "liability", "case", "in", "Jacksonville,", "Fla.,", "was", "certainly", "a", "victory", "for", "R.J.", "Reynolds", "Tobacco", "Co.,", "but", "it", "also", "could", "encourage", "negotiators", "trying", "to", "reach", "a", "settlement", "between", "the", "industry", "and", "its", "foes", "in", "talks", "that", "resumed", "yesterday", "in", "Dallas.", "The", "company’s", "victory", "in", "court—breaking", "the", "anti-smoking", "momentum", "of", "recent", "weeks—may", "soften", "the", "tone", "of", "settlement", "critics", "and", "give", "negotiators", "the", "breathing", "space", "they", "need", "to", "seek", "solutions", "to", "divisive", "issues,", "according", "to", "industry", "analysts", "and", "a", "source", "in", "the", "tobacco", "camp.", "ecle", "LEles", "1l", "\"RJR0000000026006822", "70052", "1960" ]
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2040565277.layout.json
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508939370_508939517-37.layout.json
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2060011561.layout.json
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50119548-9557-2.layout.json
[ "x", "Comparison", "of", "the", "data", "shows", "that", "elastase", "activity", "per", "cell", "is", "quite", "variable,", "though", "present", "in", "appreciable", "quantities,", "while", "the", "activity", "per", "microgram", "of", "protein", "is", "more", "consistent.", "These", "studies", "are", "to", "be", "repeated", "using", "in", "vivo", "stimulation", "of", "the", "immune", "system", "by", "Freund's", "adjuvant", "and", "BCG", "and", "in", "vitro", "stimulation", "of", "cells", "by", "colchicine,", "cytochalasin", "B", "and", "latex", "or", "silica", "phagocytosis", "to", "determine", "the", "specific", "effect", "of", "activating", "substances", "upon", "canine", "alveolar", "macrophage", "elastase.", "Due", "to", "differences", "in", "the", "activity", "of", "pancreatic", "elastases", "used", "as", "standards,", "differences", "in", "the", "definition", "of", "the", "unit", "of", "activity", "of", "elastase", "and", "differences", "in", "the", "methods", "used", "to", "assay", "elastase", "activity", "in", "this", "labora-", "tory", "and", "other", "laboratories,", "it", "would", "be", "difficult", "to", "compare", "our", "data", "directly", "with", "those", "of", "other", "investigators.", "However,", "there", "are", "certain", "conclusions", "implied", "in", "recent", "investigations", "that", "deserve", "comment.", "Levine,", "Senior", "and", "Butler®in", "1976", "attempted", "to", "determine", "the", "elastase", "activities", "of", "unstimulated", "alveolar", "macrophages", "in", "hamsters,", "rats,", "guinea", "pigs", "and", "rabbits", "with", "three", "different", "substrates.", "Although", "they", "obtained", "activity", "with", "the", "non-specific", "esterase", "substrate", "p-nitrophenyl", "N-tert", "butyloxycarbonyl", "alaninate", ",they", "failed", "to", "demonstrate", "any", "elastolytic", "activity", "with", "two", "speci~", "fic", "substrates", "after", "4", "hours", "of", "incubation.", "The", "specific", "elastase", "substrates", "used", "are", "similar", "or", "identical", "to", "the", "ones", "used", "in", "our", "laboratory", "in", "the", "present", "report.", "We", "have", "used", "a", "different", "species,", "the", "dog,", "and", "a", "lonmger", "incubation", "time", "of", "24", "hours,", "which", "provided", "a", "sensitive", "reflection", "of", "elastase", "activity", "both", "with", "the", "peptide", "substrate", "of", "Bieth?", "and", "with", "the", "solubilized", "elastin", "substrate", "of", "Keller", "and", "Mandl3,", "Janoff", "et", "al,5", "have", "indicated", "that", "the", "alveolar", "macrophage", "elastase", "appears", "to", "be", "much", "less", "vulnerable", "than", "the", "leukocyte", "elastase", "to", "the", "iphibitory", "effects", "of", "alpha]", "antitrypsin.,", "Therefore,", "it", "may", "play", "a", "more", "significant", "role", "in", "the", "pathogemesis", "of", "the", "more", "frequent", "forms", "of", "emphysema", "associated", "with", "normal", "alphay", "antitrypsin", "or", "intermediate", "levels", "of", "alphaj", "antitrypsin.", "Our", "findings", "of", "elastase", "activity", "in", "the", "unstimulated", "dog", "alveolar", "macrophage", "and", "the", "observation", "that", "these", "cells", "can", "divide", "and", "proliferate", "will", "form", "a", "basis", "for", "investigations", "of", "the", "capacity", "of", "the", "pulmonary", "alveolar", "macrophage", "to", "mediate", "elastolytic", "damage", "of", "lung", "parenchyma", "and", "for", "increased", "wnderstanding", "of", "the", "inherent", "properties", "of", "this", "cell.", "The", "data", "obtained", "will", "contribute", "to", "future", "comparisons", "between", "normal", "and", "diseased", "states", "in", "the", "dog", "and", "form", "the", "basis", "for", "projected", "studies", "of", "the", "human", "pulmonary", "alveolar", "macro-", "phage", "in", "normal", "subjects", "and", "patients", "with", "various", "forms", "of", "chronic", "obstructive", "lung", "disease.", "The", "latter", "phase", "of", "this", "study", "has", "been", "started", "and", "pemission", "for", "human", "investigation", "has", "been", "granted.", "Thus", "far,", "two", "attempts", "to", "isolate", "alveolar", "macrophages", "from", "human", "subjects", "during", "diagnostic", "bronchoscopy", "have", "been", "carried", "out", "and", "we", "have", "already", "been", "able", "to", "establish", "a", "human", "macrophage", "culture", "in", "vitro.", "50119550" ]
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0001461870-1.layout.json
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1000214721.layout.json
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80228906_80228935-23.layout.json
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0000943913-1.layout.json
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504221516_504221531-9.layout.json
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524860047+-0116-44.layout.json
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