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"mouthpiece",
"into",
"2",
"narrow,",
"centralized",
"stream.",
"Examples",
"of",
"this",
"are",
"shown",
"by",
"Nor-",
"man,",
"U.S.",
"Pat.",
"No.",
"3,860,011,",
"and",
"by",
"Dwyer",
"et",
"a],",
"U.S.",
"Ser.",
"No.",
"073,394,",
"filed",
"Sept.",
"7,",
"1979.",
"These",
"methods,",
"however,",
"direct",
"the",
"smoke",
"stream",
"against",
"a",
"small",
"area",
"of",
"the",
"smokers",
"mouth",
"or",
"tongue,",
"and",
"consequently",
"may",
"cause",
"a",
"burning",
"sensation.",
"Another",
"disadvantage",
"is",
"that",
"this",
"type",
"of",
"filter",
"with",
"2",
"centralized",
"passage",
"or",
"duct,",
"is",
"more",
"expensive",
"o",
"mass",
"produce",
"than",
"conventional",
"filters.",
"It",
"is,",
"therefore,",
"an",
"objcct",
"of",
"the",
"present",
"invention",
"to",
"provide",
"a",
"cigarette",
"that",
"gives",
"increased",
"flavor",
"to",
"the",
"smoker",
"and",
"can",
"be",
"mass",
"produced",
"Mthout",
"major",
"in-",
"Creases",
"in",
"manufacturing",
"costs.",
"It",
"is",
"also",
"an",
"object",
"of",
"the",
"present",
"invention",
"to",
"provide",
"a",
"cigarette",
"with",
"improved",
"flavor",
"that",
"may",
"be",
"produced",
"with",
"only",
"minor",
"changes",
"in",
"cigarette",
"manufacturing",
"methods.",
"SUMMARY",
"OF",
"THE",
"INVENTION",
"According",
"1o",
"the",
"present",
"invention,",
"the",
"foregoing",
"and",
"other",
"objects",
"are",
"attained",
"by",
"prowdmg",
"2",
"smoking",
"wticle",
"with",
"an",
"essentially",
"air",
"xmpcmous",
"disc",
"at",
"the",
"exit",
"f",
"the",
"smoking",
"article.",
"This",
"disc",
"is",
"Jocated",
"at",
"the",
"2p-",
"proximate",
"center",
"of",
"the",
"exit",
"end",
"of",
"the",
"smoking",
"article",
"and",
"forces",
"the",
"smoke",
"entering",
"the",
"user’s",
"mouth",
"into",
"an",
"&xpanding",
"pattern.",
"The",
"effect",
"is",
"most",
"useful",
"with",
"ciga-",
"rettes",
"having",
"reatively",
"low",
"delivery.",
"&",
"BRIEF",
"DESCRIPTION",
"OF",
"THE",
"DRAWINGS",
"A",
"more",
"complete",
"appreciation",
"of",
"the",
"invention",
"and",
"many",
"of",
"the",
"attendant",
"advantages",
"thereof",
"will",
"be",
"readily",
"apparent",
"by",
"reference",
"1o",
"the",
"following",
"detailed",
"20",
"35",
"43",
"50",
"2",
"description",
"when",
"considered",
"in",
"connection",
"with",
"the",
"accompanymg",
"drawings",
"wherein:",
"FIG.",
"1",
"is",
"a",
"prespective",
"view",
"of",
"2",
"smoking",
"article",
"according",
"1o",
"the",
"present",
"invention;",
"FIG.",
"2",
"is",
"a",
"partial",
"longitudinal",
"cross",
"section",
"of",
"the",
"invention",
"shown",
"in",
"F1G.",
"1;",
"and",
"FIG.",
"3",
"is",
"2",
"partial",
"Jongitudinal",
"cross",
"section",
"of",
"an",
"alternate",
"embodiment",
"of",
"the",
"invention.",
"DESCRIPTION",
"OF",
"THE",
"PREFERRED",
"EMBODIMENT",
"Referring",
"now",
"more",
"particularly",
"to",
"the",
"drawings",
"and",
"specifically",
"to",
"FIG.",
"1,",
"there",
"is",
"illustrated",
"a",
"preferred",
"embodiment",
"of",
"the",
"invention",
"as",
"jt",
"would",
"be",
"used",
"in",
"a2",
"smoking",
"article,",
"in",
"this",
"case",
"a",
"cigarette,",
"designated",
"gen-",
"erally",
"by",
"the",
"numeral",
"10.",
"Cigarette",
"10",
"has",
"two",
"major",
"parts,",
"smoking",
"cylinder",
"12",
"and",
"filter",
"element",
"14,",
"Filter",
"element",
"14",
"consists",
"of",
"filter",
"medium",
"18,",
"plug",
"wrapper",
"20,",
"and",
"tipping",
"paper",
"22.",
"Filter",
"medium",
"18",
"is",
"cylindrical",
"in",
"shape",
"and",
"substantially",
"conforms",
"to",
"the",
"cross",
"sectional",
"size",
"and",
"shape",
"of",
"smoking",
"cylinder",
"12.",
"The",
"filter",
"medium",
"18",
"may",
"be",
"composed",
"of",
"any",
"known",
"filtering",
"medium",
"or",
"combination",
"thereof,",
"but",
"in",
"the",
"preferred",
"embodiment,",
"the",
"filter",
"medium",
"18",
"is",
"cellulose",
"acetate.",
"Filter",
"medium",
"18",
"is",
"covered",
"with",
"plug",
"wrappcr",
"20.",
"The",
"filter",
"medium",
"18",
"abuts",
"smokmg",
"cylinder",
"12",
"and",
"is",
"attached",
"w0",
"smoking",
"cylinder",
"12",
"in",
"a",
"conventional",
"manner.",
"In",
"the",
"preferred",
"embodiment,",
"filter",
"medium",
"18",
"is",
"attached",
"1o",
"smoking",
"cylinder",
"12",
"by",
"use",
"of",
"tpping",
"paper",
"22.",
"Disc",
"24",
"is",
"an",
"area",
"on",
"the",
"smoke",
"exit",
"surface",
"of",
"filter",
"medium",
"18",
"that",
"has",
"been",
"heat",
"fused.",
"The",
"heat",
"fused",
"area,",
"disc",
"24,",
"is",
"created",
"by",
"pressing",
"a",
"rod",
"of",
"hot",
"metal,",
"not",
"shown,",
"or",
"other",
"similar",
"object",
"against",
"the",
"smoke",
"exit",
"face",
"of",
"filier",
"medium",
"18.",
"This",
"method",
"of",
"forming",
"disc",
"24",
"creatss",
"a",
"small",
"indented",
"area,",
"shown",
"in",
"FIG.",
"2,",
"which",
"does",
"not",
"detract",
"from",
"the",
"overall",
"appearance",
"of",
"cigarette",
"10",
"the",
"thickness",
"of",
"the",
"heat",
"fused",
"disc",
"formed",
"by",
"this",
"method",
"is",
"approximately",
"0.05",
"(mm)",
"thick.",
"Because",
"of",
"the",
"temperature",
"of",
"the",
"metal",
"rod",
"used",
"to",
"form",
"disc",
"24,",
"and",
"the",
"pressure",
"with",
"which",
"it",
"is",
"applied",
"to",
"the",
"smoke",
"exit",
"surface",
"of",
"filter",
"medium",
"18,",
"it",
"is",
"not",
"necessary",
"10",
"maintain",
"the",
"metal-rod",
"in",
"contact",
"with",
"the",
"filter",
"medium",
"for",
"any",
"length",
"of",
"tme.",
"Thus,",
"this",
"methed",
"of",
"creating",
"disc",
"24",
"is",
"compatible",
"with",
"high",
"speed",
"ciga-",
"rette",
"manufacturing",
"machines.",
"In",
"the",
"preferred",
"embodi-",
"ment",
"the",
"metal",
"rod",
"temperature",
"is",
"360°",
"centigrade",
"(C)",
"and",
"itis",
"applied",
"10",
"filter",
"medium",
"18",
"for",
"a",
"period",
"of",
"about",
"one",
"tenth",
"second",
"with",
"sufficient",
"force",
"to",
"heat",
"fuse",
"the",
"cellulose",
"acetate",
"into",
"an",
"air",
"impervious",
"disc.",
"It",
"has",
"been",
"found",
"that",
"disc",
"24",
"functions",
"best",
"when",
"it",
"is",
"near",
"the",
"center",
"of",
"the",
"smoke",
"exit",
"face",
"of",
"filter",
"medium",
"18",
"and",
"about",
"three",
"to",
"four",
"millimeters",
"(mm)",
"in",
"diameter.",
"Larger",
"diameter",
"discs",
"tend",
"to",
"increase",
"resistance",
"to",
"draw",
"(RTD)",
"in",
"an",
"unsatisfactory",
"manner",
"and",
"smaller",
"diameter",
"discs",
"fail",
"10",
"achieve",
"the",
"desired",
"effect.",
"In",
"the",
"preferred",
"embodiment,",
"the",
"cigarett=",
"diameter",
"is",
"approx-",
"imately",
"8",
"mm.",
"F1G.",
"2",
"shows",
"the",
"eflect",
"of",
"disc",
"24",
"on",
"smoke",
"delivery",
"patterns.",
"Smoke",
"traveling",
"through",
"smoking",
"cylinder",
"12,",
"consisting",
"of",
"1obacco",
"rod",
"28",
"and",
"cigarette",
"wrapper",
"26,",
"passes",
"into",
"fitér",
"element",
"14,",
"Smoke",
"reaching",
"the",
"exit",
"face",
"of",
"filter",
"medium",
"18",
"cannot",
"pass",
"through",
"disc",
"24,",
"which",
"is",
"essentially",
"air",
"impervious,",
"and",
"consequently",
"Jeaves",
"filler",
"element",
"14",
"with",
"a",
"radial",
"velocity",
"compo-",
"gougsl’",
"CIVIRIRZ202"
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524860047+-0116-61.layout.json | [
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509790579+-0598-0.layout.json | [
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502636262_502636273-5.layout.json | [
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2046807567_7643-28.layout.json | [
"837",
"1505",
"PHILIP",
"MORRIS",
"CO",
"CRS-28",
"such",
"an",
"observation",
"could",
"have",
"2",
"substantial",
"consequences",
"for",
"on",
"possible",
"mitigation",
"actions.",
"In",
"addition,",
"dose-response",
"analyses",
"can",
"be",
"used",
"as",
"an",
"additional",
"test",
"of",
"the",
"possible",
"role",
"of",
"confounders",
"and",
"misclassification",
"biases",
"in",
"explaining",
"reported",
"ETS",
"health",
"risk.",
"Also,",
"most",
"analyses",
"of",
"other",
"potential",
"environmental",
"hazards",
"consider",
"the",
"effect",
"of",
"dose",
"levels",
"when",
"assessing",
"the",
"possibility",
"of",
"public",
"health",
"dangers",
"and",
"policy",
"response.",
"Regulations",
"to",
"protect",
"the",
"public",
"from",
"such",
"hazards",
"usually",
"have",
"exposure",
"limitations",
"rather",
"than",
"banning",
"exposure",
"altogether.",
"Given",
"the",
"potential",
"importance",
"of",
"dose-response",
"relationships",
"for",
"ETS",
"and",
"the",
"extensive",
"comments",
"that",
"have",
"already",
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"made",
"on",
"the",
"EPA",
"‘analysis",
"of",
"the",
"average",
"relative",
"rigk,",
"this",
"analysis",
"has",
"chosen",
"to",
"concentrate",
"on",
"the",
"dose-response",
"issue.",
"Turning",
"to",
"more",
"specific",
"measures",
"of",
"exposure",
"does,",
"however,",
"introduce",
"a8",
"potential",
"new",
"form",
"of",
"bias",
"recail",
"bias.",
"The",
"more",
"specific",
"the",
"question",
"about",
"exposure,",
"the",
"more",
"precise",
"the",
"measure,",
"but",
"the",
"less",
"accurate",
"the",
"recall.",
"That",
"is,",
"there",
"is",
"likely",
"to",
"be",
"a",
"very",
"small",
"error",
"rate",
"in",
"reporting",
"marriage",
"to",
"a",
"smoker,",
"but",
"there",
"could",
"be",
"a",
"significant",
"error",
"in",
"reporting",
"actual",
"amounts",
"of",
"exposure,",
"such",
"as",
"numbers",
"of",
"cigarettes",
"smoked",
"by",
"a",
"spouse,",
"particularly",
"in",
"the",
"past.",
"In",
"reviewing",
"the",
"dese-response",
"analysis",
"of",
"ETS,",
"all",
"of",
"the",
"studies",
"listed",
"in",
"the",
"EPA",
"report",
"which",
"reported",
"dose-response",
"data",
"are",
"reviewed",
"along",
"with",
"four",
"other",
"studies,",
"not",
"considered",
"by",
"EPA,",
"which",
"also",
"examined",
"the",
"dose-response",
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"Three",
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"Brownson,",
"et.al.,",
"Stockwell,",
"et.al,,",
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"Kabat,",
"et.zl.,",
"appeared",
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"the",
"EPA",
"repert",
"was",
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"The",
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"et.al.",
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"in",
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"EPA",
"analysis.",
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"case-control",
"method.",
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"cohort",
"studies.",
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"were",
"selected",
"from",
"various",
"sources",
"of",
"lung",
"cancer",
"patients",
"or",
"those",
"who",
"recently",
"died",
"of",
"lung",
"cancer,",
"and",
"the",
"controls",
"were",
"chosen",
"using",
"various",
"random",
"selection",
"techniques.",
"Only",
"individuals",
"who",
"stated",
"that",
"they",
"had",
"never",
"smoked,",
"or,",
"in",
"some",
"cases,",
"had",
"quit",
"several",
"years",
"prior",
"to",
"the",
"study,",
"were",
"selected",
"as",
"participants",
"in",
"the",
"case",
"and",
"control",
"groups.",
"The",
"participants",
"were",
"interviewed",
"directly",
"if",
"possible",
"2",
"number",
"of",
"the",
"cases",
"in",
"nearly",
"all",
"of",
"the",
"studies",
"required",
"surrogates",
"~",
"to",
"determine",
"exposure",
"to",
"ETS",
"and",
"other",
"information",
"relevant",
"to",
"the",
"studies.",
"For",
"example,",
"data",
"on",
"age,",
"educational",
"}evel",
"obtained,",
"cccupation,",
"and",
"other",
"factors",
"were",
"obtained",
"to",
"permit",
"matehing",
"of",
"controls",
"and",
"cases",
"and",
"to",
"eliminate",
"as",
"many",
"factars",
"as",
"possible",
"that",
"may",
"obscure",
"the",
"results.",
"In",
"addition,",
"many",
"of",
"the",
"studies",
"attempted",
"to",
"obtain",
"data",
"on",
"dietary",
"hsbits",
"in",
"order",
"to",
"control",
"for",
"these",
"potential",
"confounders",
"in",
"caleulating",
"the",
"relative",
"risk",
"values.",
"More",
"will",
"be",
"presented",
"on",
"this",
"issue",
"below.",
"Finally",
"in",
"all",
"of",
"these",
"studies,",
"the",
"cases",
"and",
"controls",
"who",
"stated",
"they",
"had",
"been",
"exposed",
"to",
"ETS",
"were",
"asked",
"for",
"information",
"about",
"the",
"extent",
"of",
"exposure.",
"4%",
"$ee",
"Appendix",
"C",
"for",
"list",
"of",
"studies",
"used",
"in",
"the",
"table.",
"DRAFT",
"SUBJECT",
"TO",
"REVISION.",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"S65L089%0¢%"
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2022161585_2022161648-41.layout.json | [
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2080257711.layout.json | [
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"Rittweger,",
"Karen",
"L.",
"o",
"From:",
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"Karen",
"L.",
"Sent:",
"Friday,",
"July",
"14,",
"2000",
"12:35",
"PM",
"To:",
"Browning,",
"Andrew",
"(Leo",
"Burnett)",
"Cc:",
"Codelia,",
"Margie",
"E.;",
"Cavone,",
"Mark",
"A.",
"Subject:",
"RE:",
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"Milds",
"on",
"the",
"Database",
"On",
"the",
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"brand",
"question,",
"|",
"would",
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"only",
"defauit",
"if",
"the",
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"wrote",
"Marlboro",
"Milds",
"(which",
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"the",
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"of",
"why",
"we",
"changed",
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"question",
"to",
"begin",
"with,",
"right...",
"capture",
"more",
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"than",
"just",
"Marlboro).",
"And,",
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"default",
"would",
"not",
"only",
"need",
"to",
"go",
"to",
"a",
"milds",
"tar",
"level,",
"but",
"also",
"to",
"menthol.",
"Currently,",
"where",
"is",
"Milds",
"being",
"captured...",
"in",
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"could",
"move",
"to",
"Medium...",
"so,",
"at",
"least,",
"any",
"Marlboro",
"Menthol",
"Medium",
"would",
"be",
"considered",
"Milds.",
"But,",
"I'm",
"still",
"not",
"clear",
"on",
"what",
"the",
"next",
"steps",
"are.",
"Basically:",
"*",
"What",
"is",
"happening",
"today",
"if",
"a",
"smoker",
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"Milds",
"as",
"regular",
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"imagine",
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"a",
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"Non",
"Menthol",
"Lights",
"smoker",
"on",
"a",
"database",
"pull.",
"s",
"What",
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"steps",
"can",
"we",
"take",
"to",
"begin",
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"as",
"if",
"our",
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"surveys",
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"while.",
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"filis",
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"a",
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"Mentho!",
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"If",
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"medium,",
"I'm",
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"why",
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"couldn't",
"also",
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"it",
"Menthol.",
"«",
"When",
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"we",
"think",
"we",
"could",
"get",
"everything",
"in",
"place",
"(database,",
"survey,",
"supplier)",
"for",
"a",
"true",
"and",
"accurate",
"read",
"on",
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"Milds?"
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2046807567_7643-36.layout.json | [
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"7",
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"ETS",
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"o",
"have",
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"7.5",
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"deaths.",
"This",
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"by",
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"disesse",
"and",
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"the",
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"any",
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"The",
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"swudies",
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"confounders",
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"be",
"responsible",
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"the",
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"ETS",
"risk",
"values,",
"particularly",
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"While",
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"non",
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"it",
"is",
"uncertan",
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"1ing",
"cancer.",
"THere",
"atre",
"several",
"reasons",
"for",
"this.",
"irst,",
"with",
"few",
"exceptions",
"the",
"measired",
"telative",
"risk",
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"confounders",
"are",
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"are",
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"as",
"uncertain",
"ss",
"the",
"ETS",
"values,",
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"a",
"result,",
"in",
"order",
"to",
"account",
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"mueh",
"or",
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"measured",
"risk",
"value,",
"a",
"confounder",
"or",
"combination",
"of",
"confounders",
"*2",
"Gary",
"D.",
"Friedman,",
"et.al,",
"Ameriean",
"Journa]",
"of",
"Public",
"Health,",
"Vol.",
"73,",
"No.",
"4,",
"Apri!",
"1983,",
"P.401-405,",
"8",
"Alavanjs,",
"M.C.R,",
"et.al",
"Cancer",
"Causes",
"and",
"Contral,",
"Vol.",
"6,",
"1995,",
"».209.",
"DRAFT",
"SUBJECT",
"TO",
"REVISION,",
"NOT",
"FOR",
"QUOTATION",
"OR",
"ATTRIBUTION.",
"£09L08970%"
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"aware",
"that",
"the",
"meeting",
"is",
"NOW",
"scheduled",
"until",
"4",
"PM.",
"We",
"would",
"like",
"to",
"use",
"PowerPoint",
"projection",
"and",
"can",
"bring",
"either",
"our",
"own",
"notebook",
"or",
"the",
"presentation",
"on",
"a",
"jump-drive",
"for",
"the",
"computer",
"you",
"provide.",
"Please",
"let",
"us",
"know",
"whether",
"this",
"would",
"work.",
"Rager",
"Original",
"Message--—--",
"From:",
"Walk,",
"Roger",
"A.",
"Sent:",
"Monday,",
"January",
"10,",
"2005",
"6:38",
"PM",
"To:",
"'gregconn@ix.netcom.com’",
"Cce:",
"Solana,",
"Rick",
"P.;",
"Shafer,",
"Ken",
"H.;",
"Osborne,",
"Kevin",
"Subject:",
"Agenda",
"for",
"meeting",
"Feb.",
"7,",
"2005",
"Dear",
"Greg,",
"Rick",
"asked",
"me",
"to",
"address",
"in",
"addition",
"to",
"his",
"reply",
"on",
"Jan.",
"8,",
"2005",
"your",
"emails",
"dated",
"Dec.",
"20,",
"2004",
"and",
"Jan.",
"5,",
"2005,",
"re",
"meeting",
"agenda",
"and",
"participants",
"from",
"PM",
"USA.",
"We",
"are",
"aware",
"that",
"the",
"meeting",
"is",
"not",
"scheduled",
"until",
"4",
"PM.",
"We",
"will",
"plan",
"our",
"presentations",
"so",
"sufficient",
"time",
"is",
"available",
"for",
"a",
"scientific",
"dialogue.",
"As",
"you",
"suggested",
"we",
"can",
"add",
"'Opportunities",
"to",
"share",
"clinical",
"trial",
"information",
"of",
"the",
"Total",
"Exposure",
"Study",
"with",
"scientists",
"and",
"pubtic",
"health",
"professionals’",
"to",
"the",
"agenda",
"for",
"a",
"3:15",
"to",
"3:30",
"PM",
"timesiot.",
"We",
"will,",
"as",
"you",
"suggested,",
"discuss",
"our",
"thoughts",
"on",
"this",
"with",
"you",
"before",
"the",
"meeting.",
"1/11/2005",
"PM3006458544"
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531376115+-6129-4.layout.json | [
"RIRI",
"News",
"Report",
"May",
"6,",
"1997",
"European",
"Union",
"EU",
"BLAMES",
"BUDGET",
"FRAUD",
"ON",
"ORGANISED",
"CRIME",
"BRUSSELS,",
"May",
"6",
"(Reuter)",
"Mafia-style",
"crime",
"was",
"behind",
"a",
"major",
"part",
"of",
"detected",
"frand",
"against",
"the",
"European",
"Union’s",
"budget",
"in",
"1996,",
"which",
"rose",
"to",
"1.3",
"billion",
"Ecus",
"($1.47",
"billion),",
"the",
"European",
"Commission",
"said",
"on",
"Tuesday.",
"“International",
"organised",
"crime",
"accounts",
"for",
"a",
"lot",
"of",
"losses",
"in",
"the",
"Community",
"budget,”",
"said",
"EU",
"Anti-Fraud",
"Commissioner",
"Anita",
"Gradin,",
"presenting",
"the",
"Commission’s",
"annual",
"fraud",
"report.",
"“These",
"gangs",
"not",
"only",
"defraud",
"the",
"EU.",
"They",
"are",
"often",
"engaged",
"in",
"other",
"types",
"of",
"¢rime",
"such",
"as",
"trafficking",
"in",
"human",
"beings,",
"drug",
"smuggling,",
"car",
"theft",
"and",
"money",
"laundering,”",
"she",
"said.",
"Last",
"year,",
"4,500",
"cases",
"of",
"fraud",
"and",
"irregularities",
"were",
"reported,",
"affecting",
"especially",
"Germany",
"and",
"Italy.",
"Less",
"than",
"five",
"percent",
"of",
"the",
"cases",
"accounted",
"for",
"more",
"than",
"half",
"the",
"money",
"involved.",
"“This",
"clearly",
"shows",
"that",
"well-organised",
"international",
"crime",
"syndicates",
"are",
"responsible",
"for",
"a",
"large",
"proportion",
"of",
"the",
"losses",
"of",
"EU",
"money,”",
"Gradin",
"said...",
"Fraud",
"and",
"irregularities",
"affecting",
"budget",
"spending",
"and",
"revenue",
"detected",
"by",
"member",
"states",
"and",
"the",
"European",
"Commission",
"cost",
"the",
"EU",
"and",
"its",
"member",
"states",
"1.3",
"billion",
"Ecus",
"last",
"year",
"compared",
"to",
"1.1",
"billion",
"in",
"1995.",
"Examples",
"of",
"large",
"scale",
"fraud",
"listed",
"in",
"the",
"report",
"involved",
"cigarette",
"smuggling,",
"olive",
"oil",
"exports,",
"payments",
"of",
"value",
"added",
"tax",
"and",
"regional",
"support",
"as",
"well",
"as",
"beef",
"exports",
"and",
"imports",
"of",
"canned",
"tuna",
"and",
"much",
"else.",
"“In",
"1996",
"the",
"smuggling",
"of",
"cigarettes",
"for",
"the",
"purpose",
"of",
"fraudulent",
"sales",
"in",
"the",
"Community",
"again",
"emerged",
"as",
"the",
"chief",
"activity",
"of",
"crime",
"syndicates,”",
"the",
"Commission’s",
"report",
"said.",
"Organised",
"fraud",
"had",
"increased",
"dramaticially",
"on",
"the",
"revenue",
"side",
"of",
"the",
"EU",
"budget",
"and",
"regularities",
"with",
"customs",
"and",
"levies",
"amounted",
"to",
"787",
"million",
"Ecus",
"compared",
"with",
"717",
"million",
"in",
"1995...",
"Even",
"if",
"the",
"Europen",
"Commission’s",
"tools",
"for",
"fighting",
"fraud",
"had",
"improved",
"considerably,",
"Gradin",
"said",
"there",
"was",
"a",
"need",
"to",
"further",
"improve",
"detection,",
"recovery",
"of",
"embezzled",
"money",
"and",
"to",
"prepare",
"for",
"the",
"enlargement",
"of",
"the",
"EU.",
"“The",
"Union",
"has",
"started",
"to",
"create",
"a",
"legal",
"framework",
"to",
"protect",
"its",
"money",
"and",
"to",
"ensure",
"that",
"criminals",
"are",
"punished,”",
"she",
"said.",
"“But",
"still",
"more",
"has",
"to",
"be",
"done",
"to",
"secure",
"our",
"taxpayers’",
"money.”",
"Source:",
"RTw",
"5/6/97",
"10:27",
"AM",
"By",
"Fredrik",
"Dahi",
"Japan",
"JAPAN",
"TOBACCO",
"TAKES",
"AIM",
"AT",
"CHINESE",
"MARKET",
"6L19",
"leLeg",
"RJR0000000026006822",
"70052",
"1974"
] | [
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2043876298.layout.json | [
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"countries,",
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2022161585_2022161648-1.layout.json | [
"TJo:",
"From:",
"Subject:",
"PHILIP",
"MORRIS",
"INCORPORATED",
"INTER-OFFICE",
"CORRESPONDENCE",
"RICHMOND,",
"VIRGINIA",
"Dr.",
"R.",
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504989552_504989561-1.layout.json | [
"Statement",
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"Institute",
"on",
"S.",
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"=",
"on",
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"Mr.",
"Chairman,",
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"Lewis.",
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"I",
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"The",
"Institute's",
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"on",
"S.",
"1440.",
"As",
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"know,",
"Mr.",
"Chairman,",
"we",
"are",
"opposed",
"to",
"this",
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"to",
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"restrictions",
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"Government",
"buildings",
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"unnecessary,",
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"and,",
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524860047+-0116-36.layout.json | [
"Program",
"TUESPAY",
"MORNING,",
"SEPTEMRER",
"26,",
"2000",
"SESSION",
"A",
"SESSIONS",
"CHAIR:",
"DANNY",
"CHAMPANERI",
"8:30",
"aM",
"TUESDAY",
"29.",
"FORMATION",
"OF",
"POLYCYCLIC",
"AROMATIC",
"HYDROCARBONS",
"FROM",
"THE",
"GAS",
"PHASE",
"PYROLYSIS",
"OF",
"STEROLS:",
"THE",
"ROLE",
"OF",
"RESIDENCE",
"TIME.",
"Phillip",
"A.C.",
"Buchanan,",
"Clyde",
"Owens,",
"and",
"Todd",
"Skeen,",
"Oak",
"Ridge",
"National",
"Laboratory,",
"Oak",
"Ridge,",
"TN",
"37831",
"USA.",
"There",
"have",
"been",
"numerous",
"studies",
"on",
"the",
"formation",
"of",
"polycyclic",
"aromatic",
"hydrocarbons",
"(PAHs)",
"from",
"the",
"pyrolysis",
"of",
"tobacco",
"cornponents,",
"especially",
"those",
"found",
"in",
"the",
"hexane",
"or",
"petroleum",
"ether",
"extract",
"of",
"tobacco.",
"Early",
"studies",
"focused",
"on",
"the",
"effect",
"of",
"temperature",
"on",
"PAH",
"yields,",
"while",
"later",
"studies",
"adjusted",
"the",
"pyrolysis",
"conditions",
"to",
"produce",
"PAH",
"profiles",
"similar",
"to",
"that",
"found",
"in",
"cigarette",
"smoke",
"condensate,",
"Unfortunately,",
"all",
"these",
"pyrolysis",
"studies",
"have",
"long",
"residence",
"times",
"(typically",
"minutes)",
"which",
"are",
"not",
"relevant",
"to",
"the",
"unique",
"conditions",
"found",
"in",
"a",
"burning",
"cigarette",
"in",
"which",
"volatile",
"species",
"have",
"residence",
"times",
"of",
"<1s",
"in",
"the",
"hot",
"zone.",
"This",
"fact",
"questions",
"whether",
"the",
"specific",
"tobacco",
"constituents,",
"such",
"as",
"sterols",
"and",
"terpenes,",
"that",
"have",
"been",
"correlated",
"with",
"PAH",
"formation",
"based",
"on",
"Jong",
"residence",
"times",
"pyrolysis",
"experiments",
"are",
"the",
"same",
"constituents",
"that",
"form",
"PAHs",
"in",
"a",
"burning",
"cigarette.",
"In",
"this",
"presentation,",
"the",
"impact",
"of",
"residence",
"times",
"on",
"the",
"yield",
"of",
"PAHs",
"formed",
"frora",
"the",
"gas",
"phase",
"pyrolysis",
"of",
"sterols,",
"such",
"as",
"stigmasterol,",
"will",
"be",
"presented.",
"The",
"flow",
"pyrolysis",
"of",
"sterols",
"(in",
"helium",
"or",
"5",
"%",
"O2",
"in",
"helium)",
"will",
"be",
"investigated",
"with",
"residence",
"times",
"of",
"100",
"2000",
"ms",
"and",
"temperatures",
"of",
"500",
"—",
"800",
"°C.",
"The",
"goal",
"of",
"this",
"fundamental",
"research",
"is",
"to",
"determine",
"the",
"role",
"of",
"gas",
"phase",
"reactions",
"in",
"PAH",
"formation,",
"and",
"to",
"gain",
"insight",
"into",
"the",
"kinetics",
"and",
"mechanisms",
"of",
"PAH",
"formation",
"for",
"constituents",
"found",
"in",
"tobacco.",
"8:50",
"AM",
"TUESDAY",
"30.",
"POLYCYCLIC",
"AROMATIC",
"HYDROCARBONS",
"FROM",
"THE",
"PYROLYSIS",
"OF",
"CATECHOL",
"[C6H4({OH)2],",
"A",
"MODEL",
"FUEL",
"REPRESENTATIVE",
"OF",
"ENTITIES",
"IN",
"TOBACCO",
"Mary",
"J.",
"Wornat,",
"Elmer",
"B,",
"Ledesma,",
"and",
"Nathan",
"D.",
"Marsh.",
"Princeton",
"University,",
"Princeton,",
"NJ",
"08544-5263",
"USA.",
"In",
"order",
"to",
"better",
"understand",
"the",
"formation",
"of",
"polycyclic",
"aromatic",
"hydrocarbons",
"(PAH)",
"from",
"complex",
"fusls,",
"we",
"have",
"performed",
"pyrolysis",
"experiments",
"in",
"a",
"laminar-flow",
"reactor,",
"using",
"the",
"model",
"fuc!",
"catechol,",
"CEH4(OH)2,",
"a",
"phenol-type",
"compound",
"representative",
"of",
"structural",
"entities",
"in",
"tobacco.",
"Employing",
"high-pressure",
"liquid",
"chromatography",
"(HP1.C)",
"with",
"diode-array",
"ultraviolet-visible",
"(UV)",
"detection,",
"we",
"have",
"unequivocally",
"identified",
"fifty-two",
"individual",
"species",
"among",
"the",
"condensed-phase",
"products",
"of",
"catechol",
"pyrolysis",
"at",
"1000",
"°C",
"and",
"0.38",
"scc.",
"Of",
"these",
"fifty-two",
"species,",
"forty-two",
"have",
"never",
"before",
"been",
"identified",
"as",
"pyrolysis",
"products",
"of",
"any",
"pure",
"%",
"52486",
"0083"
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10175066_10175068-1.layout.json | [
"January",
"28,",
"1976",
"HkB1838105",
"Page",
"2",
"William",
"Gardner,",
"Fh.D.,",
"Scientific",
"Director",
"Council",
"for",
"Tobacco",
"Research",
"—",
"U.S.A.",
"re:",
"_Kenneth",
"Paigen,",
"Ph.D.",
"Paigen",
"and",
"his",
"collaborators",
"have",
"been",
"actively",
"involved",
"in",
"studies",
"of",
"aryl-hydrocarbon",
"hydroxylases",
"inducibility",
"in",
"humans.",
"They",
"suggest",
"that",
"the",
"projects",
"on",
"AHH",
"in",
"urinary",
"glucuronidase",
"are",
"similar",
"conceptually",
"and",
"in",
"many",
"cases",
"they",
"will",
"use",
"the",
"same",
"volunteer",
"patients",
"such",
"as",
"twins",
"in",
"families.",
"They",
"also",
"point",
"out",
"that",
"the",
"methodology",
"for",
"data",
"handling",
"will",
"be",
"very",
"similar.",
"Roswell",
"Park",
"admits",
"150",
"bladder",
"cancer",
"patients",
"yearly.",
"They",
"have",
"been",
"assured",
"co-",
"operation",
"for",
"their",
"studies",
"through",
"the",
"Urology",
"Department",
"(Dr.",
"C.",
"Merrin).",
"Patient",
"histery",
"on",
"admission",
"includes",
"smoking",
"history,",
"occupational",
"history,",
"the",
"names",
"and",
"addresses",
"of",
"living",
"children",
"and",
"they",
"estimate",
"that",
"on",
"the",
"basis",
"of",
"their",
"lung",
"cancer",
"studies",
"that",
"they",
"can",
"expect",
"to",
"have",
"a",
"positive",
"response",
"from",
"about",
"30%",
"of",
"progeny",
"of",
"the",
"sffected",
"patients.",
"They",
"will",
"use",
"the",
"spouse",
"of",
"the",
"progeny",
"to",
"obtain",
"apparent",
"control",
"population.",
"The",
"investigators",
"will",
"evaluate",
"whether",
"high",
"exposures",
"to",
"carcinogens",
"such",
"as",
"in",
"the",
"dye",
"industry",
"(there",
"is",
"a",
"dye",
"industry",
"in",
"the",
"Buffalo",
"area)",
"obscures",
"the",
"importance",
"of",
"genetic",
"susceptibility",
"or",
"whether",
"it",
"accentuates",
"it.",
"Workers",
"in",
"the",
"dye",
"industry",
"in",
"this",
"area,",
"as",
"in",
"other",
"parts",
"of",
"the",
"world,",
"have",
"a",
"high",
"incidence",
"of",
"bladder",
"cancer.",
"If",
"insufficient",
"cases",
"of",
"bladder",
"cancer",
"are",
"found",
"from",
"the",
"dye",
"industry",
"occupation",
"in",
"the",
"Buffalo",
"area,",
"in-",
"vestigators",
"plan",
"to",
"go",
"to",
"the",
"local",
"union",
"in",
"order",
"to",
"locate",
"bladder",
"cancer",
"cases",
"from",
"the",
"union",
"filés.",
"The",
"authors",
"point",
"out",
"they",
"do",
"not",
"necessarily",
"have",
"to",
"use",
"living",
"bladder",
"cancer",
"patients",
"since",
"they",
"will",
"measure",
"only",
"the",
"progeny.",
"Should",
"the",
"studies",
"confirm",
"the",
"hypothesis",
"that",
"urinary",
"glicuronidase",
"is",
"a",
"predisposable",
"factor",
"to",
"bladder",
"cancer,",
"the",
"authors",
"intend",
"to",
"study",
"other",
"tumor",
"types",
"including",
"lung",
"and",
"colon.",
"Should",
"progeny",
"of",
"patients",
"with",
"these",
"particular",
"tumors",
"fail",
"to",
"reveal",
"any",
"increase",
"glucuronidase",
"excretion.",
"the",
"authors",
"believe",
"that",
"this",
"negative",
"control",
"would",
"increase",
"the",
"confidence",
"and",
"the",
"significance",
"of",
"a",
"positive",
"result",
"to",
"bladder",
"cancer",
"patients.",
"The",
"investigator",
"also",
"plans",
"to",
"study",
"linkage",
"fact",
"Should",
"they",
"show",
"that",
"urinary",
"glu-",
"curonidase",
"is",
"inherited",
"as",
"a",
"single",
"gene,",
"they",
"si",
"t",
"a",
"personal",
"communication",
"which",
"suggest",
"thpt",
"man—mouse",
"somatic",
"hybrids",
"have",
"placel",
"the",
"human",
"glucuronidase",
"structural",
"gene",
"on",
"chromosome",
"7.",
"The",
"investigator",
"is",
"well-qualified",
"to",
"conduct",
"these",
"studies.",
"He",
"has",
"extensive",
"experience",
"in",
"biochemistry",
"and",
"in",
"molecular",
"genetics.",
"He",
"has",
"several",
"relevant",
"publications",
"dealing",
"with",
"the",
"rholecular",
"genetics",
"of",
"glucuronidase",
"in",
"mammals.",
"I",
"note",
"that",
"Dr.",
"Paigen",
"has",
"submitted",
"a",
"proposal",
"entitled",
"“A",
"Genetic",
"Test",
"of",
"Glucureni-",
"dase",
"in",
"Bladder",
"Cancer”",
"to",
"the",
"American",
"Cancer",
"Society.",
"and",
"he",
"has",
"a",
"note",
"which",
"indi-",
"cates",
"that",
"animal",
"experiments",
"are",
"not",
"included",
"in",
"the",
"Cancer",
"Society",
"publication.",
"In",
"the",
"American",
"Cancer",
"Society",
"application",
"he",
"states",
"that",
"if",
"awarded",
"both",
"grants",
"he",
"would",
"prefer",
"to",
"accept",
"the",
"one",
"from",
"CTR.",
"{"
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"2",
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"23rd",
"18.30",
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"Institute",
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"10",
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"12.30",
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"21.30",
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"21.30",
"10",
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"Jady",
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"(The",
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"will",
"leave",
"from",
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"the",
"Institute",
"of",
"Morbid",
"Anatomy,",
"and",
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"(900t",
"1n.00)",
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"Mrs.",
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"entertain",
"the",
"lady",
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"members",
"at",
"her",
"home.",
".",
"5",
"Anatomico-Chirurgicas",
"in",
"the",
"University",
"Hall,",
"pa-",
"1",
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"the",
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"the",
"«",
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"/",
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"the",
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"Museum",
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"lady",
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"San",
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"jn",
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"Terminillo,",
"19"
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"1563,",
"16.",
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"1963",
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"MR-",
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"Londen.",
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"a",
"Naw",
"Lobaline",
"Smek-",
"ing",
"Daterrent.",
"Curs",
"Ther",
"fles",
"SGZ-175.",
"1962",
"17.",
"Birop,",
"B",
"Frn;:lh",
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"Treatount",
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"With",
"Severe",
"Al",
"EIn,",
"i",
"Drasgit",
"About",
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"Their",
"Smeking",
"‘Hakit,",
"Brit",
"Columbia",
"Mrd",
"§",
"261454",
"18,",
"Ejrup.",
"B",
"A",
"Proposed",
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"n.gm",
"i",
"Stop",
"Smoking:",
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"Fllowsp",
"e",
"eyiish",
"Ganter",
"Soc",
"Yearbook",
"3458473,",
"1",
"19,",
"Hammond.",
"E-C.",
"snd",
"Carfukel,",
"L",
"Changes",
"in",
"Cigaretts",
"Soaiing.",
"T",
"Nt",
"Cancer",
"Inat",
"33:49-66,",
"1964",
"20,",
"Hachbaum,",
"GM:",
"Payrhosocial",
"Aspecta",
"of",
"Smeking",
"With",
"Spetial",
"Refarence",
"1o",
"Cassation,",
"Amer",
"f",
"\"Public",
"Healtk",
"38:692-677,",
":",
"A",
"Mudics!",
"ican",
"Feart",
"1",
"advisory",
"Commitics",
"o",
"the",
"Surgean",
"Seneral",
"of",
"the",
"Pulilic",
"st",
"Sanvs:",
"Smaking",
"ond",
"Healih.",
"US",
"Poslic",
"Hasith",
"Service",
"publication",
"1199,",
"1964,",
">",
"The",
"Tobasco",
"Siguion,",
"bullatina",
"107110,",
"Economic",
"Ro-",
"e",
"on",
"acviee.",
"GS",
"Dept",
"of",
"Agricsiture",
"(March-Des)",
"196+",
"3",
"Cartwright,",
"A",
"Martia,",
"F4.",
"and",
"Thompson,",
"4.6",
"Efieacy",
"of",
"4n",
"Antimmeking",
"Campaiga,",
"Lences",
"1:327-329,",
"196",
"+",
"Reyal",
"Cellege",
"of",
"Phyrigians;",
"Smokung",
"and",
"Heolsh,",
"Losdozt",
"it",
"Madica)",
"Publishing",
"Co.,",
"L.,",
"196%",
"2",
"5.",
"6,",
"Lyoch,",
"G.W.;_Smoking",
"Habits",
"of",
"Madical",
"and",
"Non-Medical",
"Uieiity",
"St;",
"Changes",
"Sinee",
"RGP,",
"Report",
"Bri¢",
"Med",
"J",
"158",
"85,",
"1963,",
"G",
"Soegin.",
"LS.",
"and",
"Lomincd,",
"OM.:",
"Surwy",
"of",
"Smakic",
"o",
"Mavsachuscra",
"Phyiciand,",
"New",
"Ene",
"J",
"Mes",
"2501002",
"1045,",
"1954.",
"2,",
"Sinty",
"Theusend",
"Anewer",
"Modern",
"Medicine",
"Smakiog",
"Surves,",
"od",
"Med",
"22:18.30",
"(March",
"2)",
"1964",
"¢",
".",
"Murphy,",
"TH..",
"1nd",
"Tiermey,",
"LT",
"Currest",
"Stetss",
"of",
"Cigre",
"e",
"M",
"amoos",
"Rbode",
"Jsmd",
"Poysicisns,",
"Rhode",
"nitand",
"Med",
"J",
"46:655-857,",
"1963",
"o",
"Cruichutank,",
"A",
"Smokers",
"Advirery",
"Cisie—Miniury",
"of",
"e",
"higury",
"Repott",
"oo",
"s",
"Experimaaial",
"Project.",
"ey",
"Buil",
"Stinies",
"Hralih",
"12110-116.July)",
"1962",
"7o,",
"Lawton",
"M.P.:",
"A",
"Graup",
"Therapautic",
"Approsch",
"(o",
"Giox",
"up",
"Savoking,",
"Appl",
"Ther",
"4:1025-1028,",
"1962,",
"L",
"Turle,",
"G.C:",
"Aa",
"lavestigation",
"Tnto",
"the",
"Therpeutic",
"Action",
"JAA,",
"Oct",
"11,",
"1965",
"¢",
"Vot",
"194,",
"No",
"2"
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87495035.layout.json | [
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"told",
"you",
"in",
"Berlin,",
"we",
"won't",
"have",
"all",
"the",
"numbers",
"firmed",
"up",
"until",
"next",
"month,",
"but",
"Marc",
"will",
"give",
"you",
"an",
"idea",
"of",
"our",
"current",
"thinking.",
"It",
"is",
"important,",
"however,",
"to",
"note",
"two",
"things.",
"First,",
"our",
"growth",
"rate",
"going",
"forward",
"will",
"not",
"match",
"the",
"20",
"percent",
"plus",
"levels",
"of",
"the",
"late",
"1980's,",
"because",
"we",
"are",
"now",
"working",
"in",
"a",
"no/low",
"inflationary",
"environment",
"and",
"we",
"cannot",
"offset",
"the",
"full",
"effect",
"of",
"our",
"loss",
"of",
"pricing",
"flexibility.",
"Instead,",
"we",
"are",
"targeting",
"for",
"low",
"double",
"digit",
"growth,",
"which",
"appears",
"to",
"be",
"the",
"sustainable",
"“running",
"rate”",
"of",
"our",
"businesses",
"going",
"forward.",
"Given",
"that",
"the",
"entire",
"consumer",
"packaged",
"goods",
"industry",
"is",
"feeling",
"the",
"same",
"price",
"pressures",
"that",
"we",
"are,",
"industry",
"growth",
"rates",
"will",
"be",
"lower",
"than",
"in",
"the",
"past",
"as",
"well.",
"Based",
"on",
"current",
"analysts",
"projections,",
"we",
"believe",
"that",
"earnings",
"growth",
"in",
"the",
"10-13",
"percent",
"range",
"will",
"position",
"us",
"well",
"relative",
"to",
"peer",
"companies’",
"performance.",
"The",
"second",
"point",
"to",
"note",
"is",
"that,",
"given",
"the",
"current",
"pricing",
"environment,",
"our",
"future",
"will",
"be",
"less",
"predictable",
"than",
"it",
"has",
"been",
"in",
"the",
"past.",
"That",
"is",
"because,",
"no",
"matter",
"how",
"carefully",
"we",
"plan,",
"we",
"can't",
"forecast",
"competitive",
"pricing",
"actions",
"and",
"reactions",
"with",
"the",
"same",
"degree",
"of",
"confidence",
"as",
"in",
"the",
"past.",
"In",
"this",
"context,",
"it",
"is",
"particularly",
"important",
"that",
"we",
"set",
"earnings",
"growth",
"targets",
"at",
"what",
"we",
"believe",
"are",
"achievable",
"levels.",
"With",
"those",
"two",
"important",
"notes",
"to",
"the",
"future",
"earnings",
"scenario,",
"let",
"us",
"focus",
"in",
"more",
"closely",
"on",
"cost",
"reduction,",
"and",
"on",
"our",
"evolving",
"plans",
"to",
"take",
"this",
"effort",
"to",
"the",
"next",
"level,",
"Alan",
"Lacy",
"is",
"going",
"to",
"describe",
"the",
"current",
"work,",
"and",
"to",
"add",
"sorme",
"detail",
"to",
"my",
"preliminary",
"comments",
"in",
"Berlin",
"last",
"month.",
"050¥.8€.102"
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430,
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743
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482,
735,
483,
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529,
735,
535,
743
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877,
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1406,
124,
1438,
135
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1450,
124,
1469,
132
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[
1407,
170,
1446,
178
],
[
1457,
170,
1471,
178
]
] |
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