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PMID:23441 | XXY Klinefelter's syndrome with bilateral cryptochidism, obesity, multiple capillary hemangiomas and telangiectasia. | A case of XXY Klinefelter's syndrome associated with bilateral cryptochidism, -ultiple capillary hemangiomas and vesical telangiectasia is reported. Testicular biopsy revealed Leydig cell hyperplasia with hyalinization of the seminiferous tubular membrane. The patient presented with recurrent hematuria. Excretory urogr... | XXY Klinefelter's syndrome with bilateral cryptochidism, obesity, multiple capillary hemangiomas and telangiectasia. A case of XXY Klinefelter's syndrome associated with bilateral cryptochidism, -ultiple capillary hemangiomas and vesical telangiectasia is reported. Testicular biopsy revealed Leydig cell hyperplasia wit... | [
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PMID:23442 | Acetohydroxamic acid: clinical studies of a urease inhibitor in patients with staghorn renal calculi. | The hydrolysis of urea by the bacterial enzyme urease pathologically increase urinary ammonia, bicarbonate, carconate and alkalinity. These factors contribute to the formation of urinary stones and to the virulence of bacteria. Acetohydroxamic acid, a potent inhibitor of urease, has been administered to 23 patients wit... | Acetohydroxamic acid: clinical studies of a urease inhibitor in patients with staghorn renal calculi. The hydrolysis of urea by the bacterial enzyme urease pathologically increase urinary ammonia, bicarbonate, carconate and alkalinity. These factors contribute to the formation of urinary stones and to the virulence of ... | [
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PMID:23449 | [Determination of the individual changes in cardiovascular system reactivity in prescribing adrenergic blockaders]. | The changes occurring in hemodynamics due to the effect of alpha-adreno-blocking agent pyrroxan and beta-blocking agent obzidan were studied in 20 patients with neurocirculatory dystonia and in 20 patients with stage IIB hypertensive disease. Forty healthy persons formed the control group. The results of the investigat... | [Determination of the individual changes in cardiovascular system reactivity in prescribing adrenergic blockaders]. The changes occurring in hemodynamics due to the effect of alpha-adreno-blocking agent pyrroxan and beta-blocking agent obzidan were studied in 20 patients with neurocirculatory dystonia and in 20 patient... | [
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PMID:23468 | Age related changes in muscle protein degradation. | In vitro autolytic degradation of sarcoplasmic proteins in red, white and cardiac muscles increases with advance in age and with increase in temperature, the rate varying with age. Higher activity is seen in the alkaline range in all age groups. Ca2+ activated proteolytic activity also increases with advance in age. | Age related changes in muscle protein degradation. In vitro autolytic degradation of sarcoplasmic proteins in red, white and cardiac muscles increases with advance in age and with increase in temperature, the rate varying with age. Higher activity is seen in the alkaline range in all age groups. Ca2+ activated proteoly... | [
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PMID:23469 | Changes of adrenal catecholamines and their synthesizing enzymes during ontogenesis and aging in rats. | Male Wistar specific-pathogen-free rats aged 2, 7, 17, 30, 60, 120, 200, 360 and 600 days, all killed in experiment on the same day, were examined. The body weight significantly increased until the 200th day, the weight of adrenals until the 120th day and the adrenal protein content until the 30th day of life. The adre... | Changes of adrenal catecholamines and their synthesizing enzymes during ontogenesis and aging in rats. Male Wistar specific-pathogen-free rats aged 2, 7, 17, 30, 60, 120, 200, 360 and 600 days, all killed in experiment on the same day, were examined. The body weight significantly increased until the 200th day, the weig... | [
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PMID:23470 | Meningitis: the influence of routine otolaryngologic consultation on morbidity and mortality in 290 cases. | A prospective study was designed to obtain data on all meningitis patients admitted to a large county Communicable Disease Unit. The epidemiologic and clinical features of 290 cases were analyzed to ascertain the effect of routine O.R.L. consultation on the morbidity and mortality of this disease. The results of physic... | Meningitis: the influence of routine otolaryngologic consultation on morbidity and mortality in 290 cases. A prospective study was designed to obtain data on all meningitis patients admitted to a large county Communicable Disease Unit. The epidemiologic and clinical features of 290 cases were analyzed to ascertain the ... | [
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PMID:23482 | Renal function in patients with multiple myeloma. | Renal tubular and glomerular functions were evaluated in 35 consecutive patients with multiple myeloma and were correlated with changes in renal histopathology and myeloma protein patterns. All nine patients without Bence Jones proteinuria had CCr greater than 50 ml/min. In contrast 16/26 patients with Bence Jones prot... | Renal function in patients with multiple myeloma. Renal tubular and glomerular functions were evaluated in 35 consecutive patients with multiple myeloma and were correlated with changes in renal histopathology and myeloma protein patterns. All nine patients without Bence Jones proteinuria had CCr greater than 50 ml/min... | [
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PMID:23483 | X-linked recessive (Duchenne) muscular dystrophy (DMD) and purine metabolism: effects of oral allopurinol and adenylate. | Data are presented which suggest that Duchenne muscular dystrophy (DMD) may have some origin in a severe deficiency of total muscle adenine nucleotides. Using double-blind techniques, this possibility was tested in 16 DMD patients by giving oral allopurinol, a synthetic inhibitor of the purine catabolic enzyme xanthine... | X-linked recessive (Duchenne) muscular dystrophy (DMD) and purine metabolism: effects of oral allopurinol and adenylate. Data are presented which suggest that Duchenne muscular dystrophy (DMD) may have some origin in a severe deficiency of total muscle adenine nucleotides. Using double-blind techniques, this possibilit... | [
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PMID:23484 | [Kinetics of constitutive synthesis of polymethylgalacturonases by Penicillium digitatum as a function of the carbon source and pH]. | Constitutive biosynthesis of polymethylgalacturonases by Penicillium digitatum is most active at the postexponential growth phase. Under certain conditions, the enzymes are synthesized at the constant rate which does not depend on the conditions of nutrition of the producing culture. An increase in the concentration of... | [Kinetics of constitutive synthesis of polymethylgalacturonases by Penicillium digitatum as a function of the carbon source and pH]. Constitutive biosynthesis of polymethylgalacturonases by Penicillium digitatum is most active at the postexponential growth phase. Under certain conditions, the enzymes are synthesized at... | [
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PMID:23489 | A controlled comparative trial of clorazepate (Tranxene) and diazepam (Valium) for anxiety. | Two groups of anxious patients were treated with either clorazepate (n = 27, 15 mg at night), or diazepam (n = 27, 5 mg three times a day), and the anxiolytic effects of the treatments compared during a 22 day period. Both drugs were effective antianxiety agents (as assessed by the Hamilton Anxiety Scale, Analogue and ... | A controlled comparative trial of clorazepate (Tranxene) and diazepam (Valium) for anxiety. Two groups of anxious patients were treated with either clorazepate (n = 27, 15 mg at night), or diazepam (n = 27, 5 mg three times a day), and the anxiolytic effects of the treatments compared during a 22 day period. Both drugs... | [
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PMID:23485 | [Relationship between spore formation and synthesis of extracellular protheases in Bacillus mesentericus]. | Two phases were established in the synthesis of extracellular proteases by Bacillus mesentericus 73. When the growth rate was high, the synthesis of proteases was small. The maximum rate of the enzyme synthesis was observed when the growth decelerated and the production of spores started. The synthesis of alkaline prot... | [Relationship between spore formation and synthesis of extracellular protheases in Bacillus mesentericus]. Two phases were established in the synthesis of extracellular proteases by Bacillus mesentericus 73. When the growth rate was high, the synthesis of proteases was small. The maximum rate of the enzyme synthesis wa... | [
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PMID:23486 | [Energy characteristics of the stages of photo-dependent transport of 14C-alanine in Halobacterium halobium R1 cells]. | The energy of light is utilized by Halobacterium halobium R1 only at the very beginning of illumination at the same time as the transport of protons into the cells, as follows from comparing the data of photophosphorylation and light-dependent transport. The release of protons by the cells on further illumination sugge... | [Energy characteristics of the stages of photo-dependent transport of 14C-alanine in Halobacterium halobium R1 cells]. The energy of light is utilized by Halobacterium halobium R1 only at the very beginning of illumination at the same time as the transport of protons into the cells, as follows from comparing the data o... | [
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PMID:23487 | [Cyclic pathway of formaldehyde oxidation in Pseudomonas oleovorans]. | Operation of the dissimilatory hexulose phosphate cycle of formaldehyde oxidation in Pseudomonas oleovarans has been directly confirmed. Extracts of this typical facultative methylotroph catalyze the formation of 14CO2 from 14C-formaldehyde. The process depends on the presence of ribose-5-phosphate, NADP or NAD, and is... | [Cyclic pathway of formaldehyde oxidation in Pseudomonas oleovorans]. Operation of the dissimilatory hexulose phosphate cycle of formaldehyde oxidation in Pseudomonas oleovarans has been directly confirmed. Extracts of this typical facultative methylotroph catalyze the formation of 14CO2 from 14C-formaldehyde. The proc... | [
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PMID:23491 | Increased and decreased sensitivity to carbon catabolite repression of enzymes of acetate metabolism in mutants of Aspergillus nidulans. | The creA204, creB15 and creC27 mutations have been shown to cause carbon catabolite derepression of acetly CoA synthase and isocitrate lyase in Aspergillus nidulans. A recessive mutation, cre-34, which is linked to the creC gene, results in these enzymes being more sensitive than cre or wildtype strains to catabolite r... | Increased and decreased sensitivity to carbon catabolite repression of enzymes of acetate metabolism in mutants of Aspergillus nidulans. The creA204, creB15 and creC27 mutations have been shown to cause carbon catabolite derepression of acetly CoA synthase and isocitrate lyase in Aspergillus nidulans. A recessive mutat... | [
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PMID:23493 | [Clobazam (Frisium) in everyday practice. An open six-months' study of its efficacy and tolerance (author's transl)]. | Fifty patients suffering principally from neurotic and psychosomatic disturbances were treated for 6 months with an average of 30 mg clobazam (Frisium) per day. For documentation of the efficacy and tolerance a set of assessment scales and procedures from the ECDEU system (Early Clinical Drug Evaluation Unit) was compi... | [Clobazam (Frisium) in everyday practice. An open six-months' study of its efficacy and tolerance (author's transl)]. Fifty patients suffering principally from neurotic and psychosomatic disturbances were treated for 6 months with an average of 30 mg clobazam (Frisium) per day. For documentation of the efficacy and tol... | [
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PMID:23495 | Efficiency and cost of primary care by nurses and physician assistants. | We conducted a prospective study in a prepaid primary-care practice (health-maintenance organization) of a system in which nurses and physician assistants used protocols, and compared the efficiency and costs of this "new-health-practitioner" protocol system to a physician-only nonprotocol system. In five months, we st... | Efficiency and cost of primary care by nurses and physician assistants. We conducted a prospective study in a prepaid primary-care practice (health-maintenance organization) of a system in which nurses and physician assistants used protocols, and compared the efficiency and costs of this "new-health-practitioner" proto... | [
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PMID:23500 | Analysis of the beta-receptor mediated effect on fast-contracting skeletal muscle in vitro. | Subtetanic contractions of the isolated extensor digitorum longus (EDL) of the guinea-pig, a fast-contracting muscle, were evoked by transmural field stimulation. Isoprenaline, adrenaline, terbutaline, and noradrenaline each caused a dose-dependent increase in the force of contraction, their potencies decreasing in tha... | Analysis of the beta-receptor mediated effect on fast-contracting skeletal muscle in vitro. Subtetanic contractions of the isolated extensor digitorum longus (EDL) of the guinea-pig, a fast-contracting muscle, were evoked by transmural field stimulation. Isoprenaline, adrenaline, terbutaline, and noradrenaline each cau... | [
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PMID:23503 | Effect of 5-hydroxytryptophan on prolactin and growth hormone release in the infant rat: evidence for different neurotransmitter mediation. | In 10 day-old female and male rats, administration of 5-hydroxytryptophan (5-HTP) induced a prompt elevation in plasma prolactin (Prl) and growth hormone (GH) levels. Pretreatment with 2 serotonin (5-HT) receptor blockers, methysergide (Meth) and metergoline (MCE), markedly reduced the 5-HTP-induced Prl rise but failed... | Effect of 5-hydroxytryptophan on prolactin and growth hormone release in the infant rat: evidence for different neurotransmitter mediation. In 10 day-old female and male rats, administration of 5-hydroxytryptophan (5-HTP) induced a prompt elevation in plasma prolactin (Prl) and growth hormone (GH) levels. Pretreatment ... | [
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PMID:23501 | [New anti-migraine drugs used in the treatment of children and adolescents]. | In recent years a number of new preparations from the group of antiserotonin agents (including cyproheptadine and carbazochrome) as well as beta-adrenergic blocking agents (propranolol) and clonidine have been introduced for prevention of migraine and similar headaches. The efficiency of these drugs was studied in a gr... | [New anti-migraine drugs used in the treatment of children and adolescents]. In recent years a number of new preparations from the group of antiserotonin agents (including cyproheptadine and carbazochrome) as well as beta-adrenergic blocking agents (propranolol) and clonidine have been introduced for prevention of migr... | [
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PMID:23507 | [The human factor as a cause of flight accidents]. | Four causes of flying accidents due to human factors are discussed: physical and psycological unfitness, insufficient physical and psychological training, and flight fatigue. Ways in which these factors can be eliminated or their effects diminished are indicated, including the establishment of a national aeronautical h... | [The human factor as a cause of flight accidents]. Four causes of flying accidents due to human factors are discussed: physical and psycological unfitness, insufficient physical and psychological training, and flight fatigue. Ways in which these factors can be eliminated or their effects diminished are indicated, inclu... | [
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PMID:23508 | Enzymic detection of metachromatic leukodystrophy patients and heterozygotes. | Two unrelated families with metachromatic leukodystrophy have been examined for the leukocyte enzyme arylsufatase A. The enzyme activities clearly reflect an autosomal recessive mode of inherence. All four parents showed heterozygote enzyme levels 40-60 percent of the control range while the two affected children had l... | Enzymic detection of metachromatic leukodystrophy patients and heterozygotes. Two unrelated families with metachromatic leukodystrophy have been examined for the leukocyte enzyme arylsufatase A. The enzyme activities clearly reflect an autosomal recessive mode of inherence. All four parents showed heterozygote enzyme l... | [
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PMID:23509 | The treatment of peptic ulcer. | Recent evaluation of the time honoured use of antacids and anticholinergics in the treatment of peptic ulcer disease has not revealed persuasive evidence of efficacy above that of placebo. New drugs becoming available as medical treatments of peptic ulcer disease, viz H2-receptor antagonists and E group prostaglandin a... | The treatment of peptic ulcer. Recent evaluation of the time honoured use of antacids and anticholinergics in the treatment of peptic ulcer disease has not revealed persuasive evidence of efficacy above that of placebo. New drugs becoming available as medical treatments of peptic ulcer disease, viz H2-receptor antagoni... | [
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PMID:23511 | Localization of substance P-like immunoreactivity in nerves in the tooth pulp. | The occurrence of substance P (SP)-like immunoreactivity was studied in dental pulps of the cat. In untreated animals SP-positive fibres were found in all areas of the pulp. Most fibres were seen in central parts of the pulp but they were also observed in relation to the odontoblasts. Single, possibly unmyelinated, or ... | Localization of substance P-like immunoreactivity in nerves in the tooth pulp. The occurrence of substance P (SP)-like immunoreactivity was studied in dental pulps of the cat. In untreated animals SP-positive fibres were found in all areas of the pulp. Most fibres were seen in central parts of the pulp but they were al... | [
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PMID:23512 | Gamete development in malaria parasites: bicarbonate-dependent stimulation by pH in vitro. | Gametogenesis in Plasmodium gallinaceum involves bicarbonate-dependent processes and requires a continuous supply of glucose (presumably as an energy source). Emergence and exflagellation of gametocytes, in vitro, occur independently of the CO2 tension but are rigidly correlated with the pH of the external medium. In b... | Gamete development in malaria parasites: bicarbonate-dependent stimulation by pH in vitro. Gametogenesis in Plasmodium gallinaceum involves bicarbonate-dependent processes and requires a continuous supply of glucose (presumably as an energy source). Emergence and exflagellation of gametocytes, in vitro, occur independe... | [
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PMID:23520 | [The sympathetic nervous system inhibition in the antihypertensive effect of beta-blockers (author's transl)]. | The decrease of sympathetic activity by the beta-blocking drug, as demonstrated by the decreased electric activity of the splanchnic nerve and by the decreased urinary catecholamine reponse to tilt as well as by the decreased levels of plasma dopamine beta-hydroxylase exists not only in hypertension with elevated PRA b... | [The sympathetic nervous system inhibition in the antihypertensive effect of beta-blockers (author's transl)]. The decrease of sympathetic activity by the beta-blocking drug, as demonstrated by the decreased electric activity of the splanchnic nerve and by the decreased urinary catecholamine reponse to tilt as well as ... | [
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PMID:23525 | Haemoglobin oxygen dissociation curve in patients on regular haemodialysis. | Changes in the haemoglobin-oxygen dissociation curve (Hb-O2) and the factors which influence its position were studied before and after dialysis in 7 patients on regular haemodialysis during 20 dialyses. Seven normal subjects were used as controls. Haemoglobin showed a lower than normal affinity for O2 in uraemic patie... | Haemoglobin oxygen dissociation curve in patients on regular haemodialysis. Changes in the haemoglobin-oxygen dissociation curve (Hb-O2) and the factors which influence its position were studied before and after dialysis in 7 patients on regular haemodialysis during 20 dialyses. Seven normal subjects were used as contr... | [
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PMID:23522 | The effect of lesions of raphe nuclei on the cataleptic action of neuroleptics. | The effect of electrolytic lesions of dorsal raphe nucleus (DRN) and median raphe nucleus (MRN), produced with two methods, was tested on catalepsy produced by spiperone, pimozide and haloperidol. Using two methods of evaluating catalepsy (acc. to Delini-Stula and Morpurgo and to Costall et al.) it has been found that ... | The effect of lesions of raphe nuclei on the cataleptic action of neuroleptics. The effect of electrolytic lesions of dorsal raphe nucleus (DRN) and median raphe nucleus (MRN), produced with two methods, was tested on catalepsy produced by spiperone, pimozide and haloperidol. Using two methods of evaluating catalepsy (... | [
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PMID:23526 | Ionised calcium during haemodialysis. | In spite of the popularity of high calcium dialysate internationally, most centres in the United Kingdom continue to use a dialysate calcium of 1.5 to 1.6 mmol/L. In eleven patients studied throughout dialysis against such dialysate we conclude that it is sufficient to raise ionised calcium. Patients so treated have li... | Ionised calcium during haemodialysis. In spite of the popularity of high calcium dialysate internationally, most centres in the United Kingdom continue to use a dialysate calcium of 1.5 to 1.6 mmol/L. In eleven patients studied throughout dialysis against such dialysate we conclude that it is sufficient to raise ionise... | [
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PMID:23524 | [Nicotinamide coenzymes at the early stages of light induction of carotenogenesis in the Neurospora crassa mycelium]. | Changes in the concentration of NAD+, NADH, NADP+ and NADPH in the mycelium of the NADase free mutant of Neurospora crassa were studied during the latent stage of light induction of carotenogenesis. A 30 minute illumination by visible light brought about a stable decrease in the NADH/NAD+NADH ratio, exerting no effect ... | [Nicotinamide coenzymes at the early stages of light induction of carotenogenesis in the Neurospora crassa mycelium]. Changes in the concentration of NAD+, NADH, NADP+ and NADPH in the mycelium of the NADase free mutant of Neurospora crassa were studied during the latent stage of light induction of carotenogenesis. A 3... | [
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PMID:23527 | Peptic ulceration in kidney transplantation. | Gastroduodenal ulceration occurred in 45 patients during the post-transplantation period in a series of 500 transplantations of 434 patients. The mortality rate of this complication was high, 42%. Bleeding and perforation were the main problems. These complications occurred frequently during treatment for acute rejecti... | Peptic ulceration in kidney transplantation. Gastroduodenal ulceration occurred in 45 patients during the post-transplantation period in a series of 500 transplantations of 434 patients. The mortality rate of this complication was high, 42%. Bleeding and perforation were the main problems. These complications occurred ... | [
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PMID:23530 | Dependence of the rates of dissolution of the Fe4S4 clusters of Chromatium vinosum high-potential iron protein and ferredoxin on cluster oxidation state. | The influence of oxidation state on the pH dependence of the dissolution of the Fe(4)S(4) clusters of Chromatium vinosum ferredoxin and high-potential iron protein (HIPIP) has been studied. The first-order rate constants (k(obs)) for dissolution of both the Fe(4)S(4)(S-Cys)(4) (2-) and Fe(4)S(4)(S-Cys)(4) (3-) clusters... | Dependence of the rates of dissolution of the Fe4S4 clusters of Chromatium vinosum high-potential iron protein and ferredoxin on cluster oxidation state. The influence of oxidation state on the pH dependence of the dissolution of the Fe(4)S(4) clusters of Chromatium vinosum ferredoxin and high-potential iron protein (H... | [
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PMID:23531 | Probing of beta-adrenergic receptors by novel fluorescent beta-adrenergic blockers. | The synthesis of two high-affinity fluorescent beta-adrenergic blockers is described: dl-N(1)-[2-hydroxy-3-(1-naphthyloxy)propyl]-N(2)-(9-acridyl)-1,2-propanediamine (9-aminoacridylpropanolol, 9-AAP) and dl-N-[2-hydroxy-3-(1-naphthyloxy)propyl]-N'-dansylethylenediamine (dansyl analogue of propranolol, DAPN). Both 9-AAP... | Probing of beta-adrenergic receptors by novel fluorescent beta-adrenergic blockers. The synthesis of two high-affinity fluorescent beta-adrenergic blockers is described: dl-N(1)-[2-hydroxy-3-(1-naphthyloxy)propyl]-N(2)-(9-acridyl)-1,2-propanediamine (9-aminoacridylpropanolol, 9-AAP) and dl-N-[2-hydroxy-3-(1-naphthyloxy... | [
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PMID:23532 | Evidence for control of serotonin secretion from human platelets by hydroxyl ion transport and osmotic lysis. | Serotonin secretion from human platelets, stimulated either by thrombin or the calcium ionophore A23187, was found to be inhibited by anion transport blocking drugs such as 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (SITS), pyridoxal phosphate, probenecid, and suramin. These drugs have previously been sho... | Evidence for control of serotonin secretion from human platelets by hydroxyl ion transport and osmotic lysis. Serotonin secretion from human platelets, stimulated either by thrombin or the calcium ionophore A23187, was found to be inhibited by anion transport blocking drugs such as 4-acetamido-4'-isothiocyanostilbene-2... | [
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PMID:23533 | Experimental evidence for a kinetic and electrochemical memory in enzyme membranes. | The existence of hysteresis phenomena in artificial enzyme membranes due to the coupling of simple kinetic enzyme properties with diffusion transport processes is reported. The intramembrane pH of a urease coating on the surface of a glass pH electrode exhibits a hysteresis loop when the pH of the bulk solution varies ... | Experimental evidence for a kinetic and electrochemical memory in enzyme membranes. The existence of hysteresis phenomena in artificial enzyme membranes due to the coupling of simple kinetic enzyme properties with diffusion transport processes is reported. The intramembrane pH of a urease coating on the surface of a gl... | [
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PMID:23534 | Identification of transmembrane bridging proteins in the plasma membrane of cultured mouse L cells. | Studies were carried out to identify transmembrane bridging proteins in the plasma membrane of mouse L-929 cells. Cells grown in suspension culture were 125I-labeled by lactoperoxidase and allowed to ingest latex particles to produce inside-out membrane phagosome preparations. Phagosomes were isolated and the inner mem... | Identification of transmembrane bridging proteins in the plasma membrane of cultured mouse L cells. Studies were carried out to identify transmembrane bridging proteins in the plasma membrane of mouse L-929 cells. Cells grown in suspension culture were 125I-labeled by lactoperoxidase and allowed to ingest latex particl... | [
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PMID:23535 | A pH-conditional mutant of Escherichia coli. | Mutants of Escherichia coli have been isolated that are able to grow on lactose at pH 7.0 but not at pH 8.1. One of these mutants was analyzed and shown to map in the Z region of the lactose operon. beta-Galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23) activity in toluenized mutant cells at pH 8.0 was o... | A pH-conditional mutant of Escherichia coli. Mutants of Escherichia coli have been isolated that are able to grow on lactose at pH 7.0 but not at pH 8.1. One of these mutants was analyzed and shown to map in the Z region of the lactose operon. beta-Galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23) activi... | [
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PMID:23536 | Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide. | D-Lysergic acid diethylamide and D-2-bromolysergic acid diethylamide are competitive antagonists of the histamine activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); E.C. 4.6.1.1] in broken cell preparations of the hippocampus and cortex of guinea pig brain. The adenylate cyclase is linked to the hist... | Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide. D-Lysergic acid diethylamide and D-2-bromolysergic acid diethylamide are competitive antagonists of the histamine activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); E.C. 4.6.1.1] in broken cell preparations ... | [
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PMID:23537 | Heptadecapeptide gastrin in the vagal nerve. | Immunoreactive gastrin was present in vagal nerves from cats, dogs, and human beings. The abdominal portion of the vagus contained gastrin in amounts ranging from 16 to 273 pmol/g of nerve tissue (wet weight). The thoracic and cervical portion of the vagi contained only minute amounts of gastrin. Gel chromatography of ... | Heptadecapeptide gastrin in the vagal nerve. Immunoreactive gastrin was present in vagal nerves from cats, dogs, and human beings. The abdominal portion of the vagus contained gastrin in amounts ranging from 16 to 273 pmol/g of nerve tissue (wet weight). The thoracic and cervical portion of the vagi contained only minu... | [
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PMID:23566 | Prostaglandin release by slow reacting substance from guinea pig and human lung tissue. | Slow reacting substance (SRS) injected into the pulmonary artery released prostaglandins E (PGE) and F2alpha (PGF2alpha) and the 15-keto-13, 14-dihydro PG metabolites from non-sensitized and ovalbumin sensitized, isolated, perfused guinea pig lungs. PGs were also released from lungs incubated with SRS. Sensitized lungs... | Prostaglandin release by slow reacting substance from guinea pig and human lung tissue. Slow reacting substance (SRS) injected into the pulmonary artery released prostaglandins E (PGE) and F2alpha (PGF2alpha) and the 15-keto-13, 14-dihydro PG metabolites from non-sensitized and ovalbumin sensitized, isolated, perfused ... | [
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PMID:23564 | Dynamic and structural features of a case of compulsive neurosis as revealed in dreams. | Several examples of the manifest dreams reported by a patient with a compulsive neurosis are presented. An outstanding feature of the dreams was the sudden shift of the dreamer's self-representation from the role of criminal to the role of policeman. This shift is thought to parallel the oscillation between unconscious... | Dynamic and structural features of a case of compulsive neurosis as revealed in dreams. Several examples of the manifest dreams reported by a patient with a compulsive neurosis are presented. An outstanding feature of the dreams was the sudden shift of the dreamer's self-representation from the role of criminal to the ... | [
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PMID:23580 | [Mental illness and stress]. | Main purpose of my presentation was to give a review on the effects of the stress-factors on the psyche. This aspect has not been taken into consideration sufficiently yet in theory of stress. I like to stress once more that it is the excessive, too intensive stress reaction which is leading to psychic disturbances as ... | [Mental illness and stress]. Main purpose of my presentation was to give a review on the effects of the stress-factors on the psyche. This aspect has not been taken into consideration sufficiently yet in theory of stress. I like to stress once more that it is the excessive, too intensive stress reaction which is leadin... | [
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PMID:23588 | Control of extracellular slime accumulation in monokaryons and resultant dikaryons of Schizophyllum commune. | Extracellular slime accumulation, as alcohol-precipitable material was measured after eight days of growth in glucose-asparagine-salts broth in twenty-two different monokaryons and six resultant dikaryons of Schizophyllum commune. The nutritional control of slime accumulation was also examined in monokaryotic mycelium.... | Control of extracellular slime accumulation in monokaryons and resultant dikaryons of Schizophyllum commune. Extracellular slime accumulation, as alcohol-precipitable material was measured after eight days of growth in glucose-asparagine-salts broth in twenty-two different monokaryons and six resultant dikaryons of Sch... | [
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PMID:23589 | Lipolytic enzymes of Trichophyton rubrum. | Trichophyton rubrum cells contain lipase, phospholipases A and B and acyl CoA lysolecithin acyl transferase activities. This dermatophyte excretes lipase and phospholipase A into the growth medium when cultivated in Sabouraud's broth. Extracellular lipase has optimum activity at pH 8.0 whereas the intracellular lipase ... | Lipolytic enzymes of Trichophyton rubrum. Trichophyton rubrum cells contain lipase, phospholipases A and B and acyl CoA lysolecithin acyl transferase activities. This dermatophyte excretes lipase and phospholipase A into the growth medium when cultivated in Sabouraud's broth. Extracellular lipase has optimum activity a... | [
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PMID:23595 | [The prevention of accidents in dental local anesthesia]. | The relatively rare complications developing under local anaesthesia may be due to various causes. The possibilities of the development of accidents under local anaesthesia are outlined; and prophylactic and therapeutic measures are deduced. A schematic premedication cannot prevent the development of complications with... | [The prevention of accidents in dental local anesthesia]. The relatively rare complications developing under local anaesthesia may be due to various causes. The possibilities of the development of accidents under local anaesthesia are outlined; and prophylactic and therapeutic measures are deduced. A schematic premedic... | [
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PMID:23599 | Uric acid calculi: results of conservative treatment. | A total of 140 patients with uric acid diathesis have been treated for the last five years with a standardized mixture of sodium and potassium citrate and citric acid (Uralyt U) together with forced fluid intake and, if necessary, the addition of allopurinol. The results have been encouraging; 80 per cent of the patien... | Uric acid calculi: results of conservative treatment. A total of 140 patients with uric acid diathesis have been treated for the last five years with a standardized mixture of sodium and potassium citrate and citric acid (Uralyt U) together with forced fluid intake and, if necessary, the addition of allopurinol. The re... | [
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PMID:23600 | Endocrine tests in phenotypic children with bilateral impalpable testes can reliably predict "congenital" anorchism. | Congenital anorchism is a rare condition. Bilateral impa-pable undescended testes are relatively common by comparison. Surgical exploration has been regarded as the final arbiter between anorchism and bilateral cryptorchism. Exploration has not proved completely reliable in making this differentiation. Endocrine studie... | Endocrine tests in phenotypic children with bilateral impalpable testes can reliably predict "congenital" anorchism. Congenital anorchism is a rare condition. Bilateral impa-pable undescended testes are relatively common by comparison. Surgical exploration has been regarded as the final arbiter between anorchism and bi... | [
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PMID:23602 | [Acid-base indices in ovine blood and cerebrospinal fluid]. | By means of the Astrup apparatus (Blood Microsystem BMS 2) acid-base indices in blood and cerebro-spinal fluid of clinically healthy Merino sheep at the age of one year (15 head) and of two or three years (41 head) were determined. Blood collected anaerobically from v. jugularis and liquor collected by means of the sub... | [Acid-base indices in ovine blood and cerebrospinal fluid]. By means of the Astrup apparatus (Blood Microsystem BMS 2) acid-base indices in blood and cerebro-spinal fluid of clinically healthy Merino sheep at the age of one year (15 head) and of two or three years (41 head) were determined. Blood collected anaerobicall... | [
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PMID:23608 | [Rat brain and liver glutamine synthetase and gamma-glutamyltransferase activity in alloxan diabetes (IV)]. | Glutamine synthetase and gamma-glutamyltransferase activities of brain and liver homogenates of rats suffering from alloxan diabetes were determined in the soluble fraction (fraction 1) and in that obtained after treatment with 0.2 percent deoxycholate (fraction 2). The results obtained indicate that the activities of ... | [Rat brain and liver glutamine synthetase and gamma-glutamyltransferase activity in alloxan diabetes (IV)]. Glutamine synthetase and gamma-glutamyltransferase activities of brain and liver homogenates of rats suffering from alloxan diabetes were determined in the soluble fraction (fraction 1) and in that obtained after... | [
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PMID:23609 | [Mechanisms regulating citric acid metabolism in the brain]. | The changes in the rates of citrate biosynthesis and utilization in rat brain, liver, kidney and heart, produced by hypoxia, action of 2,4-DNP and thyreotoxicosis, were compared with changes of some regulatory parameters under the same conditions. The comparison of citrate-synthase activities, citrate levels in tissues... | [Mechanisms regulating citric acid metabolism in the brain]. The changes in the rates of citrate biosynthesis and utilization in rat brain, liver, kidney and heart, produced by hypoxia, action of 2,4-DNP and thyreotoxicosis, were compared with changes of some regulatory parameters under the same conditions. The compari... | [
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PMID:23612 | Comparative metabolism of benorylate and an equivalent mixture of aspirin and paracetamol in neonate and adult rabbits. | 1. Benorylate was well absorbed in rabbits, but more slowly than an equimolar mixture of aspirin and paracetamol. 2. Benorylate was extensively hydrolysed and converted to the typical metabolites of aspirin and paracetamol by both neonate and mature rabbits. 3. Absorption of either aspirin-paracetamol or benorylate was... | Comparative metabolism of benorylate and an equivalent mixture of aspirin and paracetamol in neonate and adult rabbits. 1. Benorylate was well absorbed in rabbits, but more slowly than an equimolar mixture of aspirin and paracetamol. 2. Benorylate was extensively hydrolysed and converted to the typical metabolites of a... | [
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PMID:23611 | Orofacial dyskinesia. Clinical features, mechanisms and drug therapy. | Orofacial or tardive dyskinesias are involuntary repetitive movements of the mouth and face. In most cases, they occur in older psychotic patients who are in institutions and in whom long-term treatment with antipsychotic drugs of the phenothiazine and butyrophenone groups is being carried out. These dyskinesias are fr... | Orofacial dyskinesia. Clinical features, mechanisms and drug therapy. Orofacial or tardive dyskinesias are involuntary repetitive movements of the mouth and face. In most cases, they occur in older psychotic patients who are in institutions and in whom long-term treatment with antipsychotic drugs of the phenothiazine a... | [
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PMID:23613 | [Metabolic acidosis in chronic renal insufficiency of various etiology]. | The renal acidosis may appear by a decrease of the number of nephrons able to function (decrease of the filtrate of the glomerulum) as well as by a selective alteration of the tubular acidification mechanism. In 66 patients with chronic renal insufficiency of different degrees of severity (32 patients with diabetic glo... | [Metabolic acidosis in chronic renal insufficiency of various etiology]. The renal acidosis may appear by a decrease of the number of nephrons able to function (decrease of the filtrate of the glomerulum) as well as by a selective alteration of the tubular acidification mechanism. In 66 patients with chronic renal insu... | [
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PMID:23614 | [Use of the 25-point ocular grid plate in quantitative-morphological studies of eutopic and dystopic testes of children]. | From plains histologic preparations of children's testicles the volume of seminiferous tubules and extratubular tissue were calculated by use of the points counting method. In ectopic testicles, the extratubular part is significantly larger than in normally descended testes. The range of the values measured by this met... | [Use of the 25-point ocular grid plate in quantitative-morphological studies of eutopic and dystopic testes of children]. From plains histologic preparations of children's testicles the volume of seminiferous tubules and extratubular tissue were calculated by use of the points counting method. In ectopic testicles, the... | [
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PMID:23615 | [Consideration of the mesenchyme-reaction in patients with cronical liver-diseases (author's transl)]. | The lysosomal glycosidase N-Acetyl-beta-glucosaminidase (beta-NAG) is involved in the breakdown of connective tissue. The activity of this enzyme was determined in sera and biopsies of liver tissue from patients with chronic diseases of the liver of different aetiology. Elevation of enzyme activity was found to be rela... | [Consideration of the mesenchyme-reaction in patients with cronical liver-diseases (author's transl)]. The lysosomal glycosidase N-Acetyl-beta-glucosaminidase (beta-NAG) is involved in the breakdown of connective tissue. The activity of this enzyme was determined in sera and biopsies of liver tissue from patients with ... | [
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PMID:23616 | gamma-Radiolyses of DNA in oxygenated aqueous solution. Structure of an alkali-labile site. | Erythritol-1-d1 has been isolated from gamma-irradiated aqueous oxygenated solution of DNA after reductions with NaBD4, alkali and phosphatase treatment. It is concluded that this product stems from a D-erythrose 2,4-diphosphate unit in the DNA which is formed via a sequence of reactions following H-abstraction at C-2'... | gamma-Radiolyses of DNA in oxygenated aqueous solution. Structure of an alkali-labile site. Erythritol-1-d1 has been isolated from gamma-irradiated aqueous oxygenated solution of DNA after reductions with NaBD4, alkali and phosphatase treatment. It is concluded that this product stems from a D-erythrose 2,4-diphosphate... | [
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PMID:23630 | Effect of ligands of ferric hemes on interaction between ferric and ferrous chains in partially oxidized hemoglobin A. | Normal values of Bohr effect of oxygenation of partially oxidized hemoglobin A with ferrihemes liganded either with H2O and OH or with CN have been found in the range of pH values from 6.8 to 7.6 in 45 micrometer (Fe)-hemoglobin containing 36--38% of ferrihemes. As the changes of oxygen affinity of Hb A induced by chan... | Effect of ligands of ferric hemes on interaction between ferric and ferrous chains in partially oxidized hemoglobin A. Normal values of Bohr effect of oxygenation of partially oxidized hemoglobin A with ferrihemes liganded either with H2O and OH or with CN have been found in the range of pH values from 6.8 to 7.6 in 45... | [
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PMID:23631 | [The effect of thyroxine on the 2,3-diphosphoglycerate content of erythrocytes in vivo and in vitro]. | After ending a continous treatment with thyroxine the average dropping of the 2,3 DPG level was 0.4 mumol/ml. T4 decreased on the average by 7.6 microgram/ml. One time application of 1 mg thyroxine p.o. led within 24 hours to an increase of the 2,3 DPG level of -chi = 0.2 mumol/ml, the pH in the erythrocytes increased ... | [The effect of thyroxine on the 2,3-diphosphoglycerate content of erythrocytes in vivo and in vitro]. After ending a continous treatment with thyroxine the average dropping of the 2,3 DPG level was 0.4 mumol/ml. T4 decreased on the average by 7.6 microgram/ml. One time application of 1 mg thyroxine p.o. led within 24 h... | [
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PMID:23634 | Characteristics of a new abnormal variant of G-6-PD in human red cells. | Kinetic and electrophoretic properties were studied in 230--300 fold purified preparations of glucose-6-phosphate dehydrogenase (G-6-PD) from red cells of donors and patients with hemolytic anemia induced by G-6-PD deficiency. In abnormal variant of G-6-PD isolated from red cells of a patient with hemolytic anemia whic... | Characteristics of a new abnormal variant of G-6-PD in human red cells. Kinetic and electrophoretic properties were studied in 230--300 fold purified preparations of glucose-6-phosphate dehydrogenase (G-6-PD) from red cells of donors and patients with hemolytic anemia induced by G-6-PD deficiency. In abnormal variant o... | [
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PMID:23635 | Regulation of NAD and NADP synthesis in human red cell. | NAD is synthesized in red cell from nicotinic acid and PRPP through the formation of nicotinate mononucleotide and desamido-NAD. Synthesis of one mole of NAD requires two moles of ATP. NADP comes from NAD phosphorylation by NAD-kinase (EC.2.7.1.23). NAD and NADP analysis on a population with ATP level ranging from 800 ... | Regulation of NAD and NADP synthesis in human red cell. NAD is synthesized in red cell from nicotinic acid and PRPP through the formation of nicotinate mononucleotide and desamido-NAD. Synthesis of one mole of NAD requires two moles of ATP. NADP comes from NAD phosphorylation by NAD-kinase (EC.2.7.1.23). NAD and NADP a... | [
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PMID:23636 | [Glucose-6-phosphate dehydrogenase deficiency of erythrocytes in the GDR]. | 34 persons with G-6-PD deficiency were diagnosed, and the pathological enzyme-variants of red blood cells were characterized according to the recommendations of WHO. We conclude from the differing residual G-6-PD-activities in red blood cells of the propositi and the differing reactivity of the enzyme in kinetic and ph... | [Glucose-6-phosphate dehydrogenase deficiency of erythrocytes in the GDR]. 34 persons with G-6-PD deficiency were diagnosed, and the pathological enzyme-variants of red blood cells were characterized according to the recommendations of WHO. We conclude from the differing residual G-6-PD-activities in red blood cells of... | [
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PMID:23637 | [Detection of female heterozygous glucose-6-phosphate dehydrogenase deficiency]. | Diagnostics of heterozygotes are required for population studies, for the detection and consultation of persons with G-6-PD deficiency prone to hemolysis. The diagnostics of heterozygous females with the corresponding trait are problematic in families without hemizygous patients. 1. The determination of the activity is... | [Detection of female heterozygous glucose-6-phosphate dehydrogenase deficiency]. Diagnostics of heterozygotes are required for population studies, for the detection and consultation of persons with G-6-PD deficiency prone to hemolysis. The diagnostics of heterozygous females with the corresponding trait are problematic... | [
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PMID:23638 | Mechanism of senescence of red blood cells. | An integral hypothesis is submitted on the interaction of endogenous and exogenous factors in the mechanism of senescence of erythrocytes and on their selective phagocytosis by autologous macrophages. A method that allows quantitative determination and preparative yield of senescent erythrocytes is proposed. | Mechanism of senescence of red blood cells. An integral hypothesis is submitted on the interaction of endogenous and exogenous factors in the mechanism of senescence of erythrocytes and on their selective phagocytosis by autologous macrophages. A method that allows quantitative determination and preparative yield of se... | [
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PMID:23642 | [Sedimentation rate of erythrocytes as an indicator for phase transitions in the membrane]. | Temperature dependent sedimentation measurements with human erythrocytes showed that the sedimentation velocity at 21 degrees C in Krebs-Ringer-solution, pH 7.4, has a peak shaped minimum [1]. In further investigations it could be shown that a phase transition of membrane lipids is the main reason of this peak. Membran... | [Sedimentation rate of erythrocytes as an indicator for phase transitions in the membrane]. Temperature dependent sedimentation measurements with human erythrocytes showed that the sedimentation velocity at 21 degrees C in Krebs-Ringer-solution, pH 7.4, has a peak shaped minimum [1]. In further investigations it could ... | [
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PMID:23644 | Serum gamma-glutamyl transpeptidase: its clinical significance. | Serum gamma-glutamyl transpeptidase (gamma-GT) level was estimated in 132 patients with different liver diseases (chronic persistent and chronic active hepatitis, postnecrotic cirrhosis, chronic alcholic hepatitis and alcoholic cirrhosis, cholestasis syndrome, fatty liver, Gilbert disease) and malignancies with and wit... | Serum gamma-glutamyl transpeptidase: its clinical significance. Serum gamma-glutamyl transpeptidase (gamma-GT) level was estimated in 132 patients with different liver diseases (chronic persistent and chronic active hepatitis, postnecrotic cirrhosis, chronic alcholic hepatitis and alcoholic cirrhosis, cholestasis syndr... | [
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PMID:23645 | [Painful ophthalmoplegia (author's transl)]. | The authors begin by enumerating the various syndromes in which painful ophthalmoplegia may be observed (sphenoidal fissure syndrome, Collier's syndrome, syndromes involving the orbital apex, the cavernous sinus and parasellar syndromes; Raeder's syndrome, Gradenigo's syndrome and Fischer-Brugge syndrome). They then di... | [Painful ophthalmoplegia (author's transl)]. The authors begin by enumerating the various syndromes in which painful ophthalmoplegia may be observed (sphenoidal fissure syndrome, Collier's syndrome, syndromes involving the orbital apex, the cavernous sinus and parasellar syndromes; Raeder's syndrome, Gradenigo's syndro... | [
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PMID:23648 | Naphthylamidase used as a lysosome marker in the study of acute selective necrosis of the internal granular layer of cerebellum. | Histochemical examination of the activity of naphthylamidase (LNAse) in the cerebellar cortex of 70 human autopsies consistantly revealed a marked activity mainly in the internal granular layer with pH optimum of 5.8. Slight enzyme activity was also localized in sites corresponding to lipofuscin deposits and areas of a... | Naphthylamidase used as a lysosome marker in the study of acute selective necrosis of the internal granular layer of cerebellum. Histochemical examination of the activity of naphthylamidase (LNAse) in the cerebellar cortex of 70 human autopsies consistantly revealed a marked activity mainly in the internal granular lay... | [
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PMID:23649 | Surface-charge characteristics of smooth and rough Salmonella typhimurium bacteria determined by aqueous two-phase partitioning and free zones electrophoresis. | Aqueous biphasic partitioning of Salmonella typhimurium S and R bacteria in a system containing 6.2 per cent (w/w) dextran 500 and 4.4 per cent (w/w) poly(ethyleneglycol) 6000 (PEG) was similar to the partition of the corresponding surface lipopolysaccharide (LPS). Further partition analysis with charged PEG showed tha... | Surface-charge characteristics of smooth and rough Salmonella typhimurium bacteria determined by aqueous two-phase partitioning and free zones electrophoresis. Aqueous biphasic partitioning of Salmonella typhimurium S and R bacteria in a system containing 6.2 per cent (w/w) dextran 500 and 4.4 per cent (w/w) poly(ethyl... | [
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PMID:23650 | Physiological and pathophysiological aspects of gastrointestinal peptide hormones. | The author made a review about the origin, the biochemistry the physiological and pathological roles of gastrointestinal peptide hormones. They originate from the APUD cell system, chemically from the ancient growth hormone, or placental lactogen. The theoretical prosecgastrin's first sequencies form the "secretin fami... | Physiological and pathophysiological aspects of gastrointestinal peptide hormones. The author made a review about the origin, the biochemistry the physiological and pathological roles of gastrointestinal peptide hormones. They originate from the APUD cell system, chemically from the ancient growth hormone, or placental... | [
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PMID:23654 | Maintenance of Glossina palpalis fed through bat's wing membrane on defibrinated blood. | Teneral laboratory-bred Glossina palpalis flies were successfully fed through bat's wing membrane on defibrinated blood by means of a technique developed in this laboratory. Using this technique almost 100% of the flies engorged blood through the membrane. Ten to fifteen flies were kept in Standard 'Geigy 10' or 'Geigy... | Maintenance of Glossina palpalis fed through bat's wing membrane on defibrinated blood. Teneral laboratory-bred Glossina palpalis flies were successfully fed through bat's wing membrane on defibrinated blood by means of a technique developed in this laboratory. Using this technique almost 100% of the flies engorged blo... | [
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PMID:23655 | [The etiology of sylvatic trichinellosis in Switzerland]. | Three Trichinella strains from Swiss wild foxes (Vulpes vulpes) were tested in crossbreeding experiments with Trichinella spiralis, T. nativa and T. nelsoni using white mice as laboratory animals. The results demonstrated that T. nelsoni Britov et Boev 1972 is the etiologic agent of sylvatic trichinellosis in Switzerla... | [The etiology of sylvatic trichinellosis in Switzerland]. Three Trichinella strains from Swiss wild foxes (Vulpes vulpes) were tested in crossbreeding experiments with Trichinella spiralis, T. nativa and T. nelsoni using white mice as laboratory animals. The results demonstrated that T. nelsoni Britov et Boev 1972 is t... | [
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PMID:23657 | [Mycetoma in Somalia - results of a survey done from 1959 to 1964]. | The Pasteur Institute studied 103 mycetoma patients in Somalia between 1959 and 1964. Grains were seen in 94 of them and this, added to cultural features, allowed the diagnosis of 60 pathogens as follows: 44 Madurella mycetomi, 1 Leptosphaeria senegalensis, 7 Pyrenochaeta romeroi (or Madurella grisea), 3 Allescheria bo... | [Mycetoma in Somalia - results of a survey done from 1959 to 1964]. The Pasteur Institute studied 103 mycetoma patients in Somalia between 1959 and 1964. Grains were seen in 94 of them and this, added to cultural features, allowed the diagnosis of 60 pathogens as follows: 44 Madurella mycetomi, 1 Leptosphaeria senegale... | [
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PMID:23658 | [Tropical entomophthoromycoses]. | A review was made about human entomophthoromycosis observed in tropical areas due to fungi of the order Entomophthorales. Rhinophycomycosis is caused by Entomophthora coronata, a cosmopolitan fungus which is only pathogen in wet tropical and subtropical climates. The disease, a muco-cutaneous infection of the face, ind... | [Tropical entomophthoromycoses]. A review was made about human entomophthoromycosis observed in tropical areas due to fungi of the order Entomophthorales. Rhinophycomycosis is caused by Entomophthora coronata, a cosmopolitan fungus which is only pathogen in wet tropical and subtropical climates. The disease, a muco-cut... | [
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PMID:23659 | Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency. | Seven urinary metabolites of tryptophan-kynurenine pathway were measured in riboflavin-deficient, pyridoxine-deficient, pair-fed and natural diet baboons. The most significant changes in the pyridoxine-deficient baboons was a mean sevenfold increase in the excretion of xanthurenic acid and a threefold decrease in 3-hyd... | Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency. Seven urinary metabolites of tryptophan-kynurenine pathway were measured in riboflavin-deficient, pyridoxine-deficient, pair-fed and natural diet baboons. The most significant changes in the pyridoxine-deficient baboons was a mean sevenfo... | [
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PMID:23660 | On the determination of free L-tryptophan. | The determination of free L-tryptophan depends on several analytical well checked points e.g. absorbing effects, pH of the serum, dependence of the throughput, concentration dependence of retention, volume ultrafiltrated, cut-off, temperature dependence of the binding rate, purification on ion-exchange column, interfer... | On the determination of free L-tryptophan. The determination of free L-tryptophan depends on several analytical well checked points e.g. absorbing effects, pH of the serum, dependence of the throughput, concentration dependence of retention, volume ultrafiltrated, cut-off, temperature dependence of the binding rate, pu... | [
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PMID:23661 | Studies on the function of tryptophan-108 on lysozyme. | Chemical studies of selective modification of Trp-108 of lysozyme gave ambiguous results concerning its function on the catalytic activity, since the oxyndole derivative obtained with N-bromosuccinimide is inactive, whereas the kynurenine derivative obtained by oxidation with ozone is fully active. In order to explain ... | Studies on the function of tryptophan-108 on lysozyme. Chemical studies of selective modification of Trp-108 of lysozyme gave ambiguous results concerning its function on the catalytic activity, since the oxyndole derivative obtained with N-bromosuccinimide is inactive, whereas the kynurenine derivative obtained by oxi... | [
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PMID:23662 | T antigen synthesis and resistance to interferon in human adenovirus type 12 infected chick cells. | Tye specific T antigen formation has been demonstrated in primary and secondary chick embryo cells (CEC) infected with adenovirus type 12. The frequency of cells synthesizing T antigen was closely dependent on the multiplicity of infection (MOI). At a MOI of 2.85 TCD50 per cell, T antigen was formed in 50% of cells. Cy... | T antigen synthesis and resistance to interferon in human adenovirus type 12 infected chick cells. Tye specific T antigen formation has been demonstrated in primary and secondary chick embryo cells (CEC) infected with adenovirus type 12. The frequency of cells synthesizing T antigen was closely dependent on the multipl... | [
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PMID:23663 | Scanning electron microscopy of L-929 cells exposed to interferon and reovirus. | L-929 cells were studied under the scanning electron microscope (SEM) in the course of reovirus infection with and without prior interferon treatment. Two major stages in the cytopathic effect (CPE) were identified on the basis of fine surface morphology as revealed by SEM. Uninfected control cells were spindle-shaped ... | Scanning electron microscopy of L-929 cells exposed to interferon and reovirus. L-929 cells were studied under the scanning electron microscope (SEM) in the course of reovirus infection with and without prior interferon treatment. Two major stages in the cytopathic effect (CPE) were identified on the basis of fine surf... | [
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PMID:23664 | The effect of supraoptimal temperature on the formation of pseudorabies virus particles. | Replication of virulent and attenuated strains of pseudorabies virus (PRV) at supraoptimal temperature was inhibited in L cells non-adapted to 40 degrees C. Electron microscopy revealed the prevalence of hollow core particles without nucleoid; both the nuclei and cytoplasm of L cells were markedly altered at supraoptim... | The effect of supraoptimal temperature on the formation of pseudorabies virus particles. Replication of virulent and attenuated strains of pseudorabies virus (PRV) at supraoptimal temperature was inhibited in L cells non-adapted to 40 degrees C. Electron microscopy revealed the prevalence of hollow core particles witho... | [
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PMID:23665 | The course of influrenza infection in mice with graft-versus-host reaction. | The course of influenza infection in mice with a developed graft-versus-host reaction (GVHR) was changed. Due to disturbances in the inflammatory process the pneumonia was delayed and less marked. Consequently, the infected mice died later than controls. Influenza virus reproduction in the lungs was more intensive and ... | The course of influrenza infection in mice with graft-versus-host reaction. The course of influenza infection in mice with a developed graft-versus-host reaction (GVHR) was changed. Due to disturbances in the inflammatory process the pneumonia was delayed and less marked. Consequently, the infected mice died later than... | [
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PMID:23666 | Evaluation of the effectiveness of receptor destroying enzyme preparations. | A procedure has been developed for testing receptor destroying enzyme (RDE) preparations used to remove nonspecific inhibitors before carrying out haemagglutination inhibition tests with influenza virus. Four criteria should be taken into account: (1) titre of RDE, usually used to indicate the activity of the preparati... | Evaluation of the effectiveness of receptor destroying enzyme preparations. A procedure has been developed for testing receptor destroying enzyme (RDE) preparations used to remove nonspecific inhibitors before carrying out haemagglutination inhibition tests with influenza virus. Four criteria should be taken into accou... | [
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PMID:23667 | Induction of interferon in mice and cell cultures by Mycoplasma pneumoniae. | Inoculation of mice and L and human embryonic lung (HEL) cell cultures with Mycoplasma pneumoniae failed to induce the production of interferon. M. pneumoniae multiplied in these cell cultures without a marked cytopathic effect. M. pneumoniae induced interferon in human peripheral blood leukocytes with maximum titres o... | Induction of interferon in mice and cell cultures by Mycoplasma pneumoniae. Inoculation of mice and L and human embryonic lung (HEL) cell cultures with Mycoplasma pneumoniae failed to induce the production of interferon. M. pneumoniae multiplied in these cell cultures without a marked cytopathic effect. M. pneumoniae i... | [
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PMID:23668 | Electron microscopic studies of the replication of mouse cytomegalovirus in mouse embryo cells. | During the replication a pathogenic and a non-pathogenic strain of mouse cytomegalovirus in mouse embryo cells, three types of progeny virus particles were observed in both cases; the virus yields of the two strains differed considerably. | Electron microscopic studies of the replication of mouse cytomegalovirus in mouse embryo cells. During the replication a pathogenic and a non-pathogenic strain of mouse cytomegalovirus in mouse embryo cells, three types of progeny virus particles were observed in both cases; the virus yields of the two strains differed... | [
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PMID:23669 | Autoantibodies in sera of rabbits immunized with influenza virus. | Rabbits immunized with purified influenza A (H3N2) virus within 4 weeks developed autoantibodies of SMA type (smooth muscle antibodies). In some of them also ABBA (antibodies against brush border of proximal renal tubuli) and ANA (anti-nuclear antibodies) were detected. This autoimmune response was found to be unrelate... | Autoantibodies in sera of rabbits immunized with influenza virus. Rabbits immunized with purified influenza A (H3N2) virus within 4 weeks developed autoantibodies of SMA type (smooth muscle antibodies). In some of them also ABBA (antibodies against brush border of proximal renal tubuli) and ANA (anti-nuclear antibodies... | [
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PMID:23670 | Ability of human polymorhonuclear blood cells to produce interferon after induction with phage double-stranded RNA. | The ability of human peripheral blood leukocytes to produce interferon in response to phage double-stranded (ds) RNA was studied. Under the conditions used, interferon was produced not only by lymphocytes but also by polymorphs and monocytes. These "pure" cultures showed no marked differences in the degree of interfero... | Ability of human polymorhonuclear blood cells to produce interferon after induction with phage double-stranded RNA. The ability of human peripheral blood leukocytes to produce interferon in response to phage double-stranded (ds) RNA was studied. Under the conditions used, interferon was produced not only by lymphocytes... | [
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PMID:23675 | Biochemical studies of pancreatic juice collected by duodenal aspiration and endoscopic cannulation of the main pancreatic duct. | Biochemical studies of pancreatic juice collected by duodenal aspiration and endoscopic cannulation of the main pancreatic duct were performed and compared in the same fasted normal subjects in seven cases. The comparison of the results shows that under the same stimulation (0.5 CU/kg/hr of GIH secretin and 75 ng/kg/hr... | Biochemical studies of pancreatic juice collected by duodenal aspiration and endoscopic cannulation of the main pancreatic duct. Biochemical studies of pancreatic juice collected by duodenal aspiration and endoscopic cannulation of the main pancreatic duct were performed and compared in the same fasted normal subjects ... | [
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PMID:23676 | Eastern equine encephalitis in Massachusetts, 1957-1976. A prospective study centered upon analyses of mosquitoes. | Reappearance of eastern equine encephalitis (EEE) in Massachusetts residents in the 1970's provided an opportunity to assess the predictive value of data on rainfall, EEE in horses, and carriage of EEE virus (EEEV) by mosquitoes, factors which had been studied annually since the last EEE outbreak in 1955-1956. The cycl... | Eastern equine encephalitis in Massachusetts, 1957-1976. A prospective study centered upon analyses of mosquitoes. Reappearance of eastern equine encephalitis (EEE) in Massachusetts residents in the 1970's provided an opportunity to assess the predictive value of data on rainfall, EEE in horses, and carriage of EEE vir... | [
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PMID:23677 | The oxygen affinity of concentrated human hemoglobin solutions and human blood. | The log P50 of normal human blood at 37 degrees C, PCO2 = 0, 21, 42, AND 57 MM Hg in the absence and in the presence of 2,3-DPG and ATP, has been determined in the pH range 7.0 to 7.6. Similar data have been obtained for human hemoglobin isotonic solutions at different protein concentrations in the presence of various ... | The oxygen affinity of concentrated human hemoglobin solutions and human blood. The log P50 of normal human blood at 37 degrees C, PCO2 = 0, 21, 42, AND 57 MM Hg in the absence and in the presence of 2,3-DPG and ATP, has been determined in the pH range 7.0 to 7.6. Similar data have been obtained for human hemoglobin is... | [
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PMID:23679 | The effect of drugs on fetal heart rate variability. | Baseline FHR variability has been quantitated into the mathematical indices of differential index (short-term variability) and interval index (long-term variability). Normal values have been determined. The effect that drugs used during labor have on FHR baseline variability has been evaluated. A clinically meaningful ... | The effect of drugs on fetal heart rate variability. Baseline FHR variability has been quantitated into the mathematical indices of differential index (short-term variability) and interval index (long-term variability). Normal values have been determined. The effect that drugs used during labor have on FHR baseline var... | [
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PMID:23680 | Aerobic glycolysis in bone: lactic acid production by rat calvaria cells in culture. | Considerable data have been accumulated on aerobic glycolysis of intact bone preparations. To test whether aerobic glycolysis is a feature of the bone cells themselves or of the localized conditions within an intact bone, cells isolated from rat calvaria were cultured and the effect of several factors on lactate produc... | Aerobic glycolysis in bone: lactic acid production by rat calvaria cells in culture. Considerable data have been accumulated on aerobic glycolysis of intact bone preparations. To test whether aerobic glycolysis is a feature of the bone cells themselves or of the localized conditions within an intact bone, cells isolate... | [
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PMID:23682 | Time course of the cerebral circulatory response to metabolic depression. | Baboons anesthetized with halothane and N2O/O2 were given an intravenous steroid anesthetic (Althesin; Glaxo Laboratories Ltd., U.K.). The drug bolus was labeled with 99mTc, and the time from central venous injection to peak radioactivity in the brain was designated drug brain arrival (DBA-peak). The electroencephalogr... | Time course of the cerebral circulatory response to metabolic depression. Baboons anesthetized with halothane and N2O/O2 were given an intravenous steroid anesthetic (Althesin; Glaxo Laboratories Ltd., U.K.). The drug bolus was labeled with 99mTc, and the time from central venous injection to peak radioactivity in the ... | [
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PMID:23684 | Antipsychotic drugs, neurotransmitters, and schizophrenia. | Inhibition of central dopamine functions appears to be a common basic property of antipsychotic drugs. The mesolimbic and nigrostriatal portions of the dopaminergic system are probably the main targets for the mental and the extrapyramidal actions, respectively, of these drugs. The fact that dopaminergic hyperfunction ... | Antipsychotic drugs, neurotransmitters, and schizophrenia. Inhibition of central dopamine functions appears to be a common basic property of antipsychotic drugs. The mesolimbic and nigrostriatal portions of the dopaminergic system are probably the main targets for the mental and the extrapyramidal actions, respectively... | [
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PMID:23689 | Quality assessment of a telephone care system utilizing non-physician personnel. | An approach to providing medical care by telephone is described and its content and quality assessed by means of an outcome study. Pediatric health assistants have been trained to evaluate, triage and offer home management advice in lieu of an office visit for medical problems presented by parents via telephone. During... | Quality assessment of a telephone care system utilizing non-physician personnel. An approach to providing medical care by telephone is described and its content and quality assessed by means of an outcome study. Pediatric health assistants have been trained to evaluate, triage and offer home management advice in lieu o... | [
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PMID:23690 | Physicians and non-physician health practitioners: the characteristics of their practices and their relationships. | Six primary care practices which utilize both physician and non-physician practitioner types were studied to measure differences between practitioner types in the care of patients. By chart review 1,369 patient-practitioner encounters were examined. Physicians identified less symptoms and signs in their patients and pr... | Physicians and non-physician health practitioners: the characteristics of their practices and their relationships. Six primary care practices which utilize both physician and non-physician practitioner types were studied to measure differences between practitioner types in the care of patients. By chart review 1,369 pa... | [
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PMID:23691 | Relationship of transmural electrical potential difference to changes in gastric mucosal permeability to H+ and blood flow. | Chambered in vivo wedges of proximal canine gastric mucosa were used to evaluate the relationship between PD, net H+ and Na+ fluxes, and gastric mucosal nutrient blood flow, as adjudicated by the ability of the mucosa to clear aminopyrine. Assuming that steady state conditions existed during the study, the results indi... | Relationship of transmural electrical potential difference to changes in gastric mucosal permeability to H+ and blood flow. Chambered in vivo wedges of proximal canine gastric mucosa were used to evaluate the relationship between PD, net H+ and Na+ fluxes, and gastric mucosal nutrient blood flow, as adjudicated by the ... | [
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PMID:23692 | Secretory state of gastric mucosa and its resistance to aspirin injury. | The influence of the secretory status on gastric mucosal tolerance to aspirin injury was assessed in a canine ex vivo model, which provided two segments of mucosa supplied by a single vascular pedicle in the same dog. Acid secretion was stimulated by intravenous infusion of histamine in one mucosa, whereas the secretor... | Secretory state of gastric mucosa and its resistance to aspirin injury. The influence of the secretory status on gastric mucosal tolerance to aspirin injury was assessed in a canine ex vivo model, which provided two segments of mucosa supplied by a single vascular pedicle in the same dog. Acid secretion was stimulated ... | [
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PMID:23696 | [Social-gerontological theories of the situation in the lives of the aged--a discussion on geroprophylaxis (author's transl)]. | The contribution discusses the most important theories which chiefly refer in a mainly sociologically orientated way to the explanation of the various forms of the process of aging: activity- and disengagement-theory. Both theories have had an exceptionally strong influence on scientific soziological research since the... | [Social-gerontological theories of the situation in the lives of the aged--a discussion on geroprophylaxis (author's transl)]. The contribution discusses the most important theories which chiefly refer in a mainly sociologically orientated way to the explanation of the various forms of the process of aging: activity- a... | [
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PMID:23697 | [The possible use of sociological onsets in theory on the problem of age and surroundings (author's transl)]. | The possibility of using sociological theories on practical problems is a main view point for judging their usefulness. From a scientific-theoretical point of view activity- and disengagement-theory are adequately examined in this contribution. By this it is shown that these theories are lacking mainly in precision and... | [The possible use of sociological onsets in theory on the problem of age and surroundings (author's transl)]. The possibility of using sociological theories on practical problems is a main view point for judging their usefulness. From a scientific-theoretical point of view activity- and disengagement-theory are adequat... | [
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PMID:23698 | [Survey on the gerontological research in the Federal Republic of Germany (author's transl)]. | This survey on the gerontological research shows the topical main accents of work in this field in the Federal Republic of Germany: Social services for aged, old-age-security, social and health situation, and older workers' problems are the most important items of the essay. Empirical examinations are dealt with separa... | [Survey on the gerontological research in the Federal Republic of Germany (author's transl)]. This survey on the gerontological research shows the topical main accents of work in this field in the Federal Republic of Germany: Social services for aged, old-age-security, social and health situation, and older workers' pr... | [
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PMID:23699 | [Problems of retirement and their mastering (author's transl)]. | Based on four functions (assignment of status and role, making one's living, reasons for social contacts, and structure of time) the importance of work and profession in a society mainly orientated on performance are shown. From this we can conclude that with retirement from the profession a lability of the level of sa... | [Problems of retirement and their mastering (author's transl)]. Based on four functions (assignment of status and role, making one's living, reasons for social contacts, and structure of time) the importance of work and profession in a society mainly orientated on performance are shown. From this we can conclude that w... | [
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PMID:23700 | [Psycho-social problems in rehabilitation (author's transl)]. | This contribution contains the results of a study on rehabilitation of patients undergoing treatment in the Alpen-Sanatorium in Bad Tölz, Germany, which was planned as a prestudy for an extensive examination of psycho-social problems of this group of patients and their chances for rehabilitation. The especially importa... | [Psycho-social problems in rehabilitation (author's transl)]. This contribution contains the results of a study on rehabilitation of patients undergoing treatment in the Alpen-Sanatorium in Bad Tölz, Germany, which was planned as a prestudy for an extensive examination of psycho-social problems of this group of patient... | [
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