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PMID:23036 | [The brain in the aged]. | Under the very broad term of brain in the elderly, we cannot consider exhaustively all the anatomical, physiopathological and pathological aspect and, still less, the therapeutic possibilities in diseases of the anesthetist should know concerning the special characteristics of this aging organ. First are recalled the a... | [The brain in the aged]. Under the very broad term of brain in the elderly, we cannot consider exhaustively all the anatomical, physiopathological and pathological aspect and, still less, the therapeutic possibilities in diseases of the anesthetist should know concerning the special characteristics of this aging organ.... | [
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PMID:23037 | [Confusional states in geriatrics]. | Illustrated by clinical reports, this study attempts to demonstrate the practical and didactic interest of various somatopsychological correlations in geriatrics. The confusional state in the elderly has no specific etiopathogenesis. It is only the expression, often disconcerting, of a method of cerebral suffering and ... | [Confusional states in geriatrics]. Illustrated by clinical reports, this study attempts to demonstrate the practical and didactic interest of various somatopsychological correlations in geriatrics. The confusional state in the elderly has no specific etiopathogenesis. It is only the expression, often disconcerting, of... | [
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PMID:23039 | [Age and other factors in the prognosis and operative indications for brain surgery]. | Attempt at evaluation of the operative risk depending on seven factors. 1--For benign tumours (Example: meningiomas): 1--greater than 65 years; 2--functional insufficiency, depending on the type of tumour; 3--the volume of the tumour; 4--site of the tumour; 5--foreseeable operative difficulties; 6--the importance of in... | [Age and other factors in the prognosis and operative indications for brain surgery]. Attempt at evaluation of the operative risk depending on seven factors. 1--For benign tumours (Example: meningiomas): 1--greater than 65 years; 2--functional insufficiency, depending on the type of tumour; 3--the volume of the tumour;... | [
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PMID:23041 | [Admission and treatment of 592 patients over 70 years in an intensive care unit]. | Using an IBM 3741 computer, the authors analysed 592 case records of patients aged over 70 years, admitted to hospital on an intensive care unit, age appears to be an important factor in determining the prognosis of numerous diseases without, however, being a criteria for rejection of admission of these patients to an ... | [Admission and treatment of 592 patients over 70 years in an intensive care unit]. Using an IBM 3741 computer, the authors analysed 592 case records of patients aged over 70 years, admitted to hospital on an intensive care unit, age appears to be an important factor in determining the prognosis of numerous diseases wit... | [
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PMID:23045 | [General anesthesia for ophthalmic surgery in patients over 80 years]. | Among 150 elderly ophthalmological patients over 80 years old, only seven patients did not undergo a general anaesthesia, because of respiratory insufficiency and/or ventricular extrasystoles. The other, 143 patients underwent 178 operations under general anaesthesia with minimal per and postsurgical complications. The... | [General anesthesia for ophthalmic surgery in patients over 80 years]. Among 150 elderly ophthalmological patients over 80 years old, only seven patients did not undergo a general anaesthesia, because of respiratory insufficiency and/or ventricular extrasystoles. The other, 143 patients underwent 178 operations under g... | [
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PMID:23046 | [Methods and indications for low peridural analgesia in the aged. Report of 300 cases]. | Continuous peridural analgesia took a long time to be accepted in current practice in surgery of the elderly, owing to the apprehensions for the possible cardiovascular consequences and also, the difficulty in using this form of anaesthesia in the elderly. The experience of more than 300 cases, collected in the Nice de... | [Methods and indications for low peridural analgesia in the aged. Report of 300 cases]. Continuous peridural analgesia took a long time to be accepted in current practice in surgery of the elderly, owing to the apprehensions for the possible cardiovascular consequences and also, the difficulty in using this form of ana... | [
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PMID:23048 | [A comparative study of the course of aged patients with hip surgery]. | On an orthopedic surgical unit we studied the course of patients aged over 70 years who had undergone surgical operation on the hip in 1974 and 1975. Distinguishing the pre-opérative, per-operative and post-operative stages, we used firstly, the distribution according to age and sex, the past history, the laboratory fi... | [A comparative study of the course of aged patients with hip surgery]. On an orthopedic surgical unit we studied the course of patients aged over 70 years who had undergone surgical operation on the hip in 1974 and 1975. Distinguishing the pre-opérative, per-operative and post-operative stages, we used firstly, the dis... | [
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PMID:23050 | [Pharmacoloby of the bronchomotor tonus during anesthesia]. | In a patient under general anesthesia, the occurrence of bronchospasm can be readily treated provided the cause is diagnosed early. The corrective drugs to dilate are readily available: atropine, epinephrine and theophylline. In the choice of preanesthetics, anesthetics and adjuvants, it is important to remember that t... | [Pharmacoloby of the bronchomotor tonus during anesthesia]. In a patient under general anesthesia, the occurrence of bronchospasm can be readily treated provided the cause is diagnosed early. The corrective drugs to dilate are readily available: atropine, epinephrine and theophylline. In the choice of preanesthetics, a... | [
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PMID:23051 | [Metabolic and pharmacologic interactions on the bronchial tonus]. | After reminding data concerning the part played by the as a rule antagonist cAMP system in moticity of the smooth muscle fibers in general and of the bronchial fibers in particular, the authors study the different types of interaction on bronchial muscular fibers which have been discribed. It is concerning the adrenerg... | [Metabolic and pharmacologic interactions on the bronchial tonus]. After reminding data concerning the part played by the as a rule antagonist cAMP system in moticity of the smooth muscle fibers in general and of the bronchial fibers in particular, the authors study the different types of interaction on bronchial muscu... | [
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PMID:23053 | [Determination of global diffusion of CO2 and its partial components under assisted respiration. Technical problems and practical value in respiratory resuscitation]. | A study of partial CO2 ductance has been performed in patients under assisted ventilation. The authors propose methods for simultaneous measurement of paCO2, PAECO2, PECO2 and PICO2. This methodology is used in patients presenting different conditions accounting for respiratory resuscitation: barbiturate poisoning with... | [Determination of global diffusion of CO2 and its partial components under assisted respiration. Technical problems and practical value in respiratory resuscitation]. A study of partial CO2 ductance has been performed in patients under assisted ventilation. The authors propose methods for simultaneous measurement of pa... | [
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PMID:23054 | [Bronchial spasm and bronchial motoricity]. | The author recalls the phenomena which control bronchomotility, without a personal study but based on recent bibliography. After recalling the bronchial nerve supply, the chemical intermediates, the various responses of the bronchial tree to autacoids, the author recalls the association of anesthesia and bronchospasm. ... | [Bronchial spasm and bronchial motoricity]. The author recalls the phenomena which control bronchomotility, without a personal study but based on recent bibliography. After recalling the bronchial nerve supply, the chemical intermediates, the various responses of the bronchial tree to autacoids, the author recalls the ... | [
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PMID:23055 | [Peroperative pneumothorax]. | Pneumothorax during operation is always clinically serious. The symptoms are usually sudden cyanosis, accompanied by cardio-vascular collapse and difficulty or even impossibility to ventilate owing to increased pressures of insufflation. Immediate or secondary bilateral pneumothorax is relatively common, then may appea... | [Peroperative pneumothorax]. Pneumothorax during operation is always clinically serious. The symptoms are usually sudden cyanosis, accompanied by cardio-vascular collapse and difficulty or even impossibility to ventilate owing to increased pressures of insufflation. Immediate or secondary bilateral pneumothorax is rela... | [
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PMID:23056 | [Significance of capnography in cases of pneumothorax occurring during artificial respiration]. | The author reports the case of a premature new-born presenting a respiratory distress syndrome who was ventilated through a tracheal tube and in whom an artificial pneumothorax developed. Capnography quickly provided accurate data allowing an adaptation of therapy. | [Significance of capnography in cases of pneumothorax occurring during artificial respiration]. The author reports the case of a premature new-born presenting a respiratory distress syndrome who was ventilated through a tracheal tube and in whom an artificial pneumothorax developed. Capnography quickly provided accurat... | [
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PMID:23057 | [Inhalation of regurgitated fluid during anesthesia]. | Since the observations of HALL in 1940 and MENDELSON in 1946 numerous clinical and experimental reports have completed our knowledge of the consequences of inhalation of fluid during anesthesia. Apart from the pulmonary signs, this syndrome includes cardiovascular signs. The course of the pulmonary disease is often unf... | [Inhalation of regurgitated fluid during anesthesia]. Since the observations of HALL in 1940 and MENDELSON in 1946 numerous clinical and experimental reports have completed our knowledge of the consequences of inhalation of fluid during anesthesia. Apart from the pulmonary signs, this syndrome includes cardiovascular s... | [
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PMID:23058 | [Complications following cementing of joint prosthesis]. | The authors studied changes in the level of lactate dehydrogenase during insertion of hip prostheseis fixed with methyl methacrylate cement. Thirty patients were studied here. In 23 of them, the L.D.H. isoenzymes were estimated. The variations in these enzymes appear 3 hours after the second fixation with cement: rise ... | [Complications following cementing of joint prosthesis]. The authors studied changes in the level of lactate dehydrogenase during insertion of hip prostheseis fixed with methyl methacrylate cement. Thirty patients were studied here. In 23 of them, the L.D.H. isoenzymes were estimated. The variations in these enzymes ap... | [
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PMID:23059 | [Pulmonary edema due to peroperative overload or anesthetic awakening]. | This report gives details of the clinical characteristics, the circumstances of onset and the treatment. There is always a blood volume overload, but the absolute value does not differ radically from that often necessary to maintain during heavy or hemorrhagic surgery, good hemodynamic conditions. The association with ... | [Pulmonary edema due to peroperative overload or anesthetic awakening]. This report gives details of the clinical characteristics, the circumstances of onset and the treatment. There is always a blood volume overload, but the absolute value does not differ radically from that often necessary to maintain during heavy or... | [
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PMID:23060 | [Anaphylactic reactions observed with anesthetics and adjuvants]. | The author reports an inquiry concerning 66 patients who all had an anaphylactoid reaction. The hour of onset, the type of reaction, (skin, bronchial or systemic), their association, the drugs responsible, and the diagnostic difficulties are reviewed. In this respect, in relation to the results of the above inquiry and... | [Anaphylactic reactions observed with anesthetics and adjuvants]. The author reports an inquiry concerning 66 patients who all had an anaphylactoid reaction. The hour of onset, the type of reaction, (skin, bronchial or systemic), their association, the drugs responsible, and the diagnostic difficulties are reviewed. In... | [
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PMID:23062 | [Effects of anesthesia and surgery on certain parameters of humoral immunity]. | Research on certain parameters of humoral immunity was undertaken in 10 patients who had undergone a major surgical operation. The control subjects were chosen among 10 subjects in good health. The tests were carried out within 24-72 hours after the operation. The determination of cytolytic lymphocyte activity, in the ... | [Effects of anesthesia and surgery on certain parameters of humoral immunity]. Research on certain parameters of humoral immunity was undertaken in 10 patients who had undergone a major surgical operation. The control subjects were chosen among 10 subjects in good health. The tests were carried out within 24-72 hours a... | [
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PMID:23063 | In vivo function tests of the effect of tilorone and niridazole on cell-mediated immunity in chickens. | The need for effective, safe, specific cellular immune suppression in avian research led to the study of effects of tilorone and niridazole on cell-mediated immunity of chickens. Two in vivo tests for cell-mediated immunity function were used--the graft-vs-host (GvH) test and the delayed hypersensitivity (DH) test. Hum... | In vivo function tests of the effect of tilorone and niridazole on cell-mediated immunity in chickens. The need for effective, safe, specific cellular immune suppression in avian research led to the study of effects of tilorone and niridazole on cell-mediated immunity of chickens. Two in vivo tests for cell-mediated im... | [
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PMID:23064 | Pharmacological and psychological determinants of smoking. A New York University honors program lecture. | Arguments for and against low-nicotine cigarettes are examined by considering evidence relevant to the gratification of smoking and to nicotine as an addicting agent. A variety of studies indicates that smokers regulate nicotine intake and that variations in smoking rate that customarily have been interpreted in psycho... | Pharmacological and psychological determinants of smoking. A New York University honors program lecture. Arguments for and against low-nicotine cigarettes are examined by considering evidence relevant to the gratification of smoking and to nicotine as an addicting agent. A variety of studies indicates that smokers regu... | [
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PMID:23067 | [E. coli penicillin amidase. Physico-chemical properties of the enzyme covalently bound to the 2-(3'-amino-4'-methoxyphenyl)-sulfonylethyl ester of cellulose]. | The effect of the procedure of the enzyme binding with the carrier on the properties of the heterogenous catalyst obtained by covalent binding of penicillinamidase (PA) with cellulose 2-(3'-amino-4'-methoxyphenyl)-sulphonylethyl ether by means of the bifunctional reagent, i.e. glutaric aldehyde was studied. It was show... | [E. coli penicillin amidase. Physico-chemical properties of the enzyme covalently bound to the 2-(3'-amino-4'-methoxyphenyl)-sulfonylethyl ester of cellulose]. The effect of the procedure of the enzyme binding with the carrier on the properties of the heterogenous catalyst obtained by covalent binding of penicillinamid... | [
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PMID:23068 | [Physiochemical properties of 7-aminoacetoxycephalosporanic acid]. | Potentiometric titration of the zwitter-ion of 7-aminoacetoxycephalosporanic acid (7-ACA) was performed and the constants of its ionization were estimated. The minimum solubility of the 7-ACA zwitter-ion (20 degrees C, 0.1 M NaCl) was determined and the solubility curve of 7-ACA at wide pH ranges was calculated. Equili... | [Physiochemical properties of 7-aminoacetoxycephalosporanic acid]. Potentiometric titration of the zwitter-ion of 7-aminoacetoxycephalosporanic acid (7-ACA) was performed and the constants of its ionization were estimated. The minimum solubility of the 7-ACA zwitter-ion (20 degrees C, 0.1 M NaCl) was determined and the... | [
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PMID:23070 | [Use of a polarographic method for determining trichothecin]. | The polarographic behaviour of trichothecin was studied. It was shown that the antibiotic could be detected in solutions at concentrations of 7.10(-7) moles with the help of the polarographic method. Conditions for the polarographic determination of trichothecin in fermentation broth were developed. The error was not m... | [Use of a polarographic method for determining trichothecin]. The polarographic behaviour of trichothecin was studied. It was shown that the antibiotic could be detected in solutions at concentrations of 7.10(-7) moles with the help of the polarographic method. Conditions for the polarographic determination of trichoth... | [
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PMID:23066 | [Detection of weak graft-versus-host reactions by the suppressive effect on the immune response (author's transl)]. | Weak graft-versus-host reactions induced between H-2 compatible strains are not detected by the splenomegaly assay in newborn mice. Similarly the proliferative response in the mixed lymphocyte culture or the popliteal lymph node assay was not extensive in some combinations. On the contrary, the inhibition of the specif... | [Detection of weak graft-versus-host reactions by the suppressive effect on the immune response (author's transl)]. Weak graft-versus-host reactions induced between H-2 compatible strains are not detected by the splenomegaly assay in newborn mice. Similarly the proliferative response in the mixed lymphocyte culture or ... | [
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PMID:23072 | Discovery of an agent in wastewater sludge that reduces the heat required to inactivate reovirus. | An agent that causes heat inactivation of reovirus to occur at reduced temperatures has been found in both raw and anaerobically digested sludge. This agent is originally associated with sludge solids but can be washed from these solids by blending with water. The activity of the agent was considerably greater in alkal... | Discovery of an agent in wastewater sludge that reduces the heat required to inactivate reovirus. An agent that causes heat inactivation of reovirus to occur at reduced temperatures has been found in both raw and anaerobically digested sludge. This agent is originally associated with sludge solids but can be washed fro... | [
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PMID:23077 | Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after short (less than 30 minutes) first febrile convulsions in children. | Twenty-nine infants and children with short (less than 30 minutes) first febrile convulsions were studied between 3 and 22 hours after convulsive episodes. Arterial and CSF acid-base variables, lactate and pyruvate concentrations, and lactate/pyruvate ratios were measured. Biochemical signs of cerebral hypoxia were fou... | Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after short (less than 30 minutes) first febrile convulsions in children. Twenty-nine infants and children with short (less than 30 minutes) first febrile convulsions were studied between 3 and 22 hours after convulsive episodes. Arterial and ... | [
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PMID:23078 | Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after convulsions of varied duration and aetiology in children. | Twenty-two infants and children were studied after convulsions of varied cause and duration. Arterial and CSF acid-base variables, lactate and pyruvate concentrations, and lactate/pyruvate ratios were measured between 3 and 18 hours after convulsive episodes. Biochemical signs of cerebral hypoxia were found in 7 patien... | Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after convulsions of varied duration and aetiology in children. Twenty-two infants and children were studied after convulsions of varied cause and duration. Arterial and CSF acid-base variables, lactate and pyruvate concentrations, and lactate... | [
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PMID:23079 | Hemodynamic effects of prolonged hyperoxia. | Experimental studies have consistently demonstrated the development of perivascular edema in the dog lung following prolonged exposure to 95% oxygen. This pathological change has been thought to result from capillary injury, but a direct effect secondary to left ventricular dysfunction has not yet been excluded. To eva... | Hemodynamic effects of prolonged hyperoxia. Experimental studies have consistently demonstrated the development of perivascular edema in the dog lung following prolonged exposure to 95% oxygen. This pathological change has been thought to result from capillary injury, but a direct effect secondary to left ventricular d... | [
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PMID:23081 | Is a left ventricular vent necessary during cardiopulmonary bypass? | This study evaluated the coronary flow and the internal diameter, pressure, and metabolism of the left ventricle using four different cardiopulmonary bypass techniques. Conditioned dogs underwent a 30-minute stabilizing period on cardiopulmonary bypass with a beating, empty heart (normothermia and a flow of 80 ml/kg/mi... | Is a left ventricular vent necessary during cardiopulmonary bypass? This study evaluated the coronary flow and the internal diameter, pressure, and metabolism of the left ventricle using four different cardiopulmonary bypass techniques. Conditioned dogs underwent a 30-minute stabilizing period on cardiopulmonary bypass... | [
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PMID:23082 | Effect of some beta-adrenergic blocking drugs on the renal bloow flow in dogs. | Using timed collection of blood returning via the renal veins, the renal blood flow was determined in anaesthetized dogs, following the intravenous injection of 3 beta-adrenergic blockers, namely propranolol, oxprenolol and pindolol. The test drugs were given as a bolus or as an infusion, and their effects on the renal... | Effect of some beta-adrenergic blocking drugs on the renal bloow flow in dogs. Using timed collection of blood returning via the renal veins, the renal blood flow was determined in anaesthetized dogs, following the intravenous injection of 3 beta-adrenergic blockers, namely propranolol, oxprenolol and pindolol. The tes... | [
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PMID:23083 | Transmitter mobilization at the frog neuromuscular junction. | During frequency facilitation of frog neuromuscular junctions depressed by Mg++, the relationship between quantal content (m) and frequency of stimulation (0.5 to 8 Hz) is exponential. The slope of the relationship (k) reflects transmitter mobilization and the zero-frequency intercept (mo) reflects the basic release pr... | Transmitter mobilization at the frog neuromuscular junction. During frequency facilitation of frog neuromuscular junctions depressed by Mg++, the relationship between quantal content (m) and frequency of stimulation (0.5 to 8 Hz) is exponential. The slope of the relationship (k) reflects transmitter mobilization and th... | [
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PMID:23084 | Further evidence for GABA-ergic mechanisms in the action of benzodiazepines. | Drugs of the benzodiazepine series (clonazepam, lorazepam, diazepam and medazepam) increase the inhibitory processes in the cerebral cortex as it has been shown by means of the recovery cycles of the intracortical response. There is a correlation between the effect on the recovery cycles and their protective action aga... | Further evidence for GABA-ergic mechanisms in the action of benzodiazepines. Drugs of the benzodiazepine series (clonazepam, lorazepam, diazepam and medazepam) increase the inhibitory processes in the cerebral cortex as it has been shown by means of the recovery cycles of the intracortical response. There is a correlat... | [
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PMID:23085 | Resolution and reconstitution of Rhodospirillum rubrum pyridine dinucleotide transhydrogenase. II. Solubilization of the membrane-bound component. | The Rhodospirillum rubrum pyridine dinucleotide transhydrogenase system is comprised of a membrane-bound component and an easily dissociable soluble factor. Active transhydrogenase complex was solubilized by extraction of chromatophores with lysolecithin. The membrane component was also extracted from membranes deplete... | Resolution and reconstitution of Rhodospirillum rubrum pyridine dinucleotide transhydrogenase. II. Solubilization of the membrane-bound component. The Rhodospirillum rubrum pyridine dinucleotide transhydrogenase system is comprised of a membrane-bound component and an easily dissociable soluble factor. Active transhydr... | [
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PMID:23086 | Influence of inorganic phosphate and organic buffers on cephalosporin production by Streptomyces clavuligerus. | A high concentration of potassium phosphate (75--100 mM) stabilized pH and supported extensive growth of Streptomyces clavuligerus in a chemically defined medium; such a concentration also inhibited cephalosporin production. Although Tris buffer was found to have detrimental effects on growth and antibiotic production,... | Influence of inorganic phosphate and organic buffers on cephalosporin production by Streptomyces clavuligerus. A high concentration of potassium phosphate (75--100 mM) stabilized pH and supported extensive growth of Streptomyces clavuligerus in a chemically defined medium; such a concentration also inhibited cephalospo... | [
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PMID:23087 | Prolactin responses to neuroleptics in normal and schizophrenic subjects. | The prolactin response to neuroleptics can serve as an index of dopamine blockade in humans. Plasma prolactin increments to single doses of chlorpromazine, and prolactin decrements to single doses of levodopa, were similar in normal and schizophrenic subjects. Antischizophrenic drugs of all chemical classes stimulated ... | Prolactin responses to neuroleptics in normal and schizophrenic subjects. The prolactin response to neuroleptics can serve as an index of dopamine blockade in humans. Plasma prolactin increments to single doses of chlorpromazine, and prolactin decrements to single doses of levodopa, were similar in normal and schizophr... | [
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PMID:23088 | The interferonogenic agent tilorone as a modulator of GvH reaction in mice. | The effects of tilorone hydrochloride (TH), a powerful interferongenic agent exhibiting also immune modulatory properties on GvH reaction was studied, using the popliteal lymph node assay in mice. Administration of TH at days 0 or +2 relative to cell transfer to recipient mice led to a significant dose-dependent reduct... | The interferonogenic agent tilorone as a modulator of GvH reaction in mice. The effects of tilorone hydrochloride (TH), a powerful interferongenic agent exhibiting also immune modulatory properties on GvH reaction was studied, using the popliteal lymph node assay in mice. Administration of TH at days 0 or +2 relative t... | [
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PMID:23091 | Physiological basis of salt tolerance in plants. | For most plants, and under most field conditions, osmotic effects of salinity greatly predominate in restricting growth and yields. In certain cases, however, specific ion effects may be decisive. These may involve either nutrition, as in calcium deficiency in some lettuce varieties, tomato, and bell peppers, or direct... | Physiological basis of salt tolerance in plants. For most plants, and under most field conditions, osmotic effects of salinity greatly predominate in restricting growth and yields. In certain cases, however, specific ion effects may be decisive. These may involve either nutrition, as in calcium deficiency in some lettu... | [
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PMID:23100 | Characteristics and postnatal development of the acid lipase activity of the rat small intestine. | Acid lipase was identified in the rat small intestine by using esters of 4-methylumbelliferone as substrates. Maximum activity towards the oleate ester was found at pH 4.0. In adult animals, the activity of acid lipase exhibited both latency and sedimentability, indicating a lyosomal localization. The activity of acid ... | Characteristics and postnatal development of the acid lipase activity of the rat small intestine. Acid lipase was identified in the rat small intestine by using esters of 4-methylumbelliferone as substrates. Maximum activity towards the oleate ester was found at pH 4.0. In adult animals, the activity of acid lipase exh... | [
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PMID:23101 | Biosynthesis of acetyl-coenzyme A in the electric organ of Torpedo marmorata in relation to acetylcholine metabolism. | Formation of acetyl-CoA through acetyl-CoA synthetase (forward reaction) and through choline acyltransferase (backward reaction) was investigated in tissue extract from the electric organ of Torpedo marmorata. When the tissue extract was submitted to gel filtration on Sephadex G-25, the formation of acetyl-CoA by acety... | Biosynthesis of acetyl-coenzyme A in the electric organ of Torpedo marmorata in relation to acetylcholine metabolism. Formation of acetyl-CoA through acetyl-CoA synthetase (forward reaction) and through choline acyltransferase (backward reaction) was investigated in tissue extract from the electric organ of Torpedo mar... | [
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PMID:23102 | Growth of liver accompanied by an increased binding of aminoacyl-transfer ribonucleic acids. | Homogenates of rat liver obtained 3 or 14 days after partial hepatectomy were used to prepare the postmicrosomal pH5-supernatant fraction and to prepare salt-wash fractions of the 40S ribosomal subunits and the 80S ribosomes. The factor-dependent binding of methionyl-tRNAfMet to ribosomes and the elongation-factor-1-de... | Growth of liver accompanied by an increased binding of aminoacyl-transfer ribonucleic acids. Homogenates of rat liver obtained 3 or 14 days after partial hepatectomy were used to prepare the postmicrosomal pH5-supernatant fraction and to prepare salt-wash fractions of the 40S ribosomal subunits and the 80S ribosomes. T... | [
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PMID:23103 | Transport and oxidation of choline by liver mitochondria. | 1. Rapid choline oxidation and the onset of P(i)-induced swelling by liver mitochondria, incubated in a sucrose medium at or above pH7.0, required the addition of both P(i) and an uncoupling agent. Below pH7.0, P(i) alone was required for rapid choline oxidation and swelling. 2. Choline oxidation was inhibited by each ... | Transport and oxidation of choline by liver mitochondria. 1. Rapid choline oxidation and the onset of P(i)-induced swelling by liver mitochondria, incubated in a sucrose medium at or above pH7.0, required the addition of both P(i) and an uncoupling agent. Below pH7.0, P(i) alone was required for rapid choline oxidation... | [
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PMID:23104 | Alterations in nicotinamide and adenine nucleotide systems during mixed-function oxidation of p-nitroanisole in perfused livers from normal and phenobarbital-treated rats. | The contents of adenine nucleotides as well as steady-state concentrations of a number of glycolytic, pentose phosphate-pathway and tricarboxylic acid-cycle intermediates were measured in extracts of livers from normal and phenobarbital-treated rats that were perfused with p-nitroanisole. Metabolites were measured in l... | Alterations in nicotinamide and adenine nucleotide systems during mixed-function oxidation of p-nitroanisole in perfused livers from normal and phenobarbital-treated rats. The contents of adenine nucleotides as well as steady-state concentrations of a number of glycolytic, pentose phosphate-pathway and tricarboxylic ac... | [
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PMID:23105 | Influence of cations at the plasma membrane in controlling polysaccharide secretion from sycamore suspension cells. | 1. Three soluble polysaccharides and a soluble protein containing hydroxyproline were secreted by sycamore suspension cultures. l-[1-(3)H]Fucose was incorporated solely into the fucose of fucoxyloglucan and l-[1-(14)C]arabinose mainly into the arabinose of arabino-galactan. [U-(14)C]Glucose was a general precursor for ... | Influence of cations at the plasma membrane in controlling polysaccharide secretion from sycamore suspension cells. 1. Three soluble polysaccharides and a soluble protein containing hydroxyproline were secreted by sycamore suspension cultures. l-[1-(3)H]Fucose was incorporated solely into the fucose of fucoxyloglucan a... | [
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PMID:23106 | Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase. | Plasma insulin concentrations in cold-adapted rats were altered acutely by administration of glucose or anti-insulin serum. Rates of fatty acid synthesis in interscapular brown adipose tissue were determined from the incorporation of 3H from 3H2O into tissue lipid. Rates of synthesis were greatly elevated after glucose... | Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase. Plasma insulin concentrations in cold-adapted rats were altered acutely by administra... | [
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PMID:23107 | Characterization and serology of the matrix protein from a nuclear-polyhedrosis virus of Trichoplusia ni before and after degradation by an endogenous proteinase. | The intact matrix protein from a nuclear-polyhedrosis virus of the cabbage looper (Trichoplusia ni), isolated after inhibition of an endogenous serine-type proteinase, was further purified by molecular-sieve chromatography. The matrix protein was associated with carbohydrate moieties, and the carbohydrate content was d... | Characterization and serology of the matrix protein from a nuclear-polyhedrosis virus of Trichoplusia ni before and after degradation by an endogenous proteinase. The intact matrix protein from a nuclear-polyhedrosis virus of the cabbage looper (Trichoplusia ni), isolated after inhibition of an endogenous serine-type p... | [
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PMID:23108 | Affinity chromatography of aminoacyl-transfer ribonucleic acid synthetases. Cognate transfer ribonucleic acid as a ligand. | The use of tRNA affinity columns for the purification of aminoacyl-tRNA synthetases was investigated. A purification method for valyl-tRNA synthetase from Bacillus stearothermophilus is described that uses two affinity columns, one containing the pure cognate tRNA, and the other containing all tRNA species except the c... | Affinity chromatography of aminoacyl-transfer ribonucleic acid synthetases. Cognate transfer ribonucleic acid as a ligand. The use of tRNA affinity columns for the purification of aminoacyl-tRNA synthetases was investigated. A purification method for valyl-tRNA synthetase from Bacillus stearothermophilus is described t... | [
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PMID:23109 | Activation studies of the multiple forms of prochymosin (prorennin). | Activation of the four separate components of prochymosin (prorennin) at pH 5.0 demonstrated that each zymogen was the precursor to an electrophoretically distinct chymosin (rennin). When the increase in milk-clotting activity with time was analysed, the mechanism of activation of unfractionated prochymosin, individual... | Activation studies of the multiple forms of prochymosin (prorennin). Activation of the four separate components of prochymosin (prorennin) at pH 5.0 demonstrated that each zymogen was the precursor to an electrophoretically distinct chymosin (rennin). When the increase in milk-clotting activity with time was analysed, ... | [
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PMID:23110 | Electron-paramagnetic-resonance studies of leghaemoglobins from soya-bean and cowpea root nodules. Identification of nitrosyl-leghaemoglobin in crude leghaemoglobin preparations. | 1. Leghaemoglobins from soya-bean (Glycine max) and cowpea (Vigna unguiculata) root nodules were purified by chromatography on DEAE-cellulose phosphate columns at pH8.0 and pH5.8, to avoid the relatively low pH (5.2) commonly used to purify these proteins. 2. E.p.r. (electron-paramagnetic-resonance) spectra of the fluo... | Electron-paramagnetic-resonance studies of leghaemoglobins from soya-bean and cowpea root nodules. Identification of nitrosyl-leghaemoglobin in crude leghaemoglobin preparations. 1. Leghaemoglobins from soya-bean (Glycine max) and cowpea (Vigna unguiculata) root nodules were purified by chromatography on DEAE-cellulose... | [
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PMID:23111 | Evidence for the role of vitamin C-6 as a cofactor of lysyl oxidase. | At 24 h after injection of 16-day chick embryos with [C-3H]pyridoxine hydrochloride, some of this label appears in the epiphysial cartilage. Over 35% of this radioactivity appears in the form of [G-3H]pyridoxal and a further 30% as other vitamin B-6 compounds. Partial purification of lysyl oxidase from the labelled epi... | Evidence for the role of vitamin C-6 as a cofactor of lysyl oxidase. At 24 h after injection of 16-day chick embryos with [C-3H]pyridoxine hydrochloride, some of this label appears in the epiphysial cartilage. Over 35% of this radioactivity appears in the form of [G-3H]pyridoxal and a further 30% as other vitamin B-6 c... | [
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PMID:23112 | Pre-steady-state kinetic studies on cytoplasmic sheep liver aldehyde dehydrogenase. | Stopped-flow experiments in which sheep liver cytoplasmic aldehyde dehydrogenase (EC 1.2.1.3) was rapidly mixed with NAD(+) and aldehyde showed a burst of NADH formation, followed by a slower steady-state turnover. The kinetic data obtained when the relative concentrations and orders of mixing of NAD(+) and propionalde... | Pre-steady-state kinetic studies on cytoplasmic sheep liver aldehyde dehydrogenase. Stopped-flow experiments in which sheep liver cytoplasmic aldehyde dehydrogenase (EC 1.2.1.3) was rapidly mixed with NAD(+) and aldehyde showed a burst of NADH formation, followed by a slower steady-state turnover. The kinetic data obta... | [
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PMID:23113 | A model for the allosteric regulation of pH-sensitive enzymes. | 1. In an enzyme that has two independent binding sites for a ligand, any inhibitor that binds solely to the free enzyme will give rise to positive co-operativity. 2. A model is considered for the allosteric control of enzymes by effectors in which their effects are mediated by ligand-induced perturbations of the ioniza... | A model for the allosteric regulation of pH-sensitive enzymes. 1. In an enzyme that has two independent binding sites for a ligand, any inhibitor that binds solely to the free enzyme will give rise to positive co-operativity. 2. A model is considered for the allosteric control of enzymes by effectors in which their eff... | [
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PMID:23114 | The reaction of Fe(III) myoglobin fluoride with reducing agents. | The reaction of reducing agents with Fe(III) myoglobin fluoride from sperm whale was studied at alkaline pH values. The rate of reduction by dithionite was indistinguishable from the rate of ligand dissociation even when the values of the rate constants for both were only 1.0 X 10(-3)S-1 (at pH 10.6). Reduction by the ... | The reaction of Fe(III) myoglobin fluoride with reducing agents. The reaction of reducing agents with Fe(III) myoglobin fluoride from sperm whale was studied at alkaline pH values. The rate of reduction by dithionite was indistinguishable from the rate of ligand dissociation even when the values of the rate constants f... | [
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PMID:23115 | 2-Deoxy-D-galactose, a substrate for the galactose-transport system of Escherichia coli. | The following observations showed that 2-deoxy-D-galactose is a useful tool for the isolation and elucidation of the activity of one system for galactose uptake into Escherichia coli. 1. 2-Deoxygalactose, which is not a substrate for growth of E. coli, was transported into strains of the organism induced for galactose ... | 2-Deoxy-D-galactose, a substrate for the galactose-transport system of Escherichia coli. The following observations showed that 2-deoxy-D-galactose is a useful tool for the isolation and elucidation of the activity of one system for galactose uptake into Escherichia coli. 1. 2-Deoxygalactose, which is not a substrate f... | [
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PMID:23116 | Evidence for an electrogenic 3-deoxy-2-oxo-D-gluconate--proton co-transport driven by the protonmotive force in Escherichia coli K12. | Evidence is presented indicating that the carrier-mediated uptake of 3-deoxy-2-oxo-D-gluconate and D-glucuronate in Escherichia coli K12 is driven by the deltapH and deltapsi components of the protonmotive force. 1. Approximately two protons enter the cells with each sugar molecule, independent of the sugar and the str... | Evidence for an electrogenic 3-deoxy-2-oxo-D-gluconate--proton co-transport driven by the protonmotive force in Escherichia coli K12. Evidence is presented indicating that the carrier-mediated uptake of 3-deoxy-2-oxo-D-gluconate and D-glucuronate in Escherichia coli K12 is driven by the deltapH and deltapsi components ... | [
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PMID:23117 | Passive ion permeability of the chromaffin-granule membrane. | 'Ghosts' of bovine chromaffin granules, in which the complex mixture of proteins and solutes normally found in the granule matrix is replaced by buffered sucrose are osmotically sensitive. They shrink when the osmotic pressure of the suspension medium is increased, and swell if solute entry is facilitated by the additi... | Passive ion permeability of the chromaffin-granule membrane. 'Ghosts' of bovine chromaffin granules, in which the complex mixture of proteins and solutes normally found in the granule matrix is replaced by buffered sucrose are osmotically sensitive. They shrink when the osmotic pressure of the suspension medium is incr... | [
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PMID:23130 | Lipid metabolism in spontaneously hypertensive rats (SHR). | Plasma cholesterol was lower in spontaneously hypertensive rats (SHR), while plasma triglyceride and free fatty acid were increased in comparison with control normotensive Wistar-Kyoto (WK) rats. Correspondingly, [1-14C]-acetate incorporation into liver cholesterol was clearly decreased in SHR as compared with WK. As f... | Lipid metabolism in spontaneously hypertensive rats (SHR). Plasma cholesterol was lower in spontaneously hypertensive rats (SHR), while plasma triglyceride and free fatty acid were increased in comparison with control normotensive Wistar-Kyoto (WK) rats. Correspondingly, [1-14C]-acetate incorporation into liver cholest... | [
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PMID:23134 | Assessment of combined oral theophylline and inhaled beta-adrenoceptor agonist bronchodilator therapy. | 1. The bronchodilator effects of 500 microgram rimiterol by pressurized aerosol, 375 mg oral theophylline and both drugs in combination were compared in a randomized, placebo-controlled, double-blind trial in eight patients with chronic, partially reversible airways obstruction. 2. The four treatments were (i) oral the... | Assessment of combined oral theophylline and inhaled beta-adrenoceptor agonist bronchodilator therapy. 1. The bronchodilator effects of 500 microgram rimiterol by pressurized aerosol, 375 mg oral theophylline and both drugs in combination were compared in a randomized, placebo-controlled, double-blind trial in eight pa... | [
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PMID:23135 | Clazepam: pharmacokinetics and effects on performance. | 1. The effects of clazepam, a new benzodiazepine (30 mg orally) on performance tests and the cardiovascular system have been compared to those of chlordiazepoxide (30 mg orally) and a placebo in a double-blind trial involving six healthy volunteers. Simultaneously, the pharmacokinetics of clazepam were investigated. 2.... | Clazepam: pharmacokinetics and effects on performance. 1. The effects of clazepam, a new benzodiazepine (30 mg orally) on performance tests and the cardiovascular system have been compared to those of chlordiazepoxide (30 mg orally) and a placebo in a double-blind trial involving six healthy volunteers. Simultaneously,... | [
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PMID:23136 | Studies of cardioselectivity and partial agonist activity in beta-adrenoceptor blockade comparing effects on heart rate and peak expiratory flow rate during exercise. | 1 The effects of beta-adrenoceptor antagonists given in single doses by oral or intravenous routes were examined in two double-blind controlled studies performed in healthy volunteers. Heart rate and peak expiratory flow rate (PEFR) were measured at rest and during standardized exercise. 2 Propranolol 80 mg and metopro... | Studies of cardioselectivity and partial agonist activity in beta-adrenoceptor blockade comparing effects on heart rate and peak expiratory flow rate during exercise. 1 The effects of beta-adrenoceptor antagonists given in single doses by oral or intravenous routes were examined in two double-blind controlled studies p... | [
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PMID:23132 | [Salicylate poisoning. Determination of the free fraction using the ultrafiltration method]. | Seventeen infants under one year of age admitted to the Emergency Service of the General Hospital of the Medical Center La Raza during the year 1976 were included in this study with the diagnosis of salicylate poisoning. Determination of plasma salicylate by the ultrafiltrate method was practiced to all patients. A dir... | [Salicylate poisoning. Determination of the free fraction using the ultrafiltration method]. Seventeen infants under one year of age admitted to the Emergency Service of the General Hospital of the Medical Center La Raza during the year 1976 were included in this study with the diagnosis of salicylate poisoning. Determ... | [
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PMID:23138 | The effects of chronic drug administration on hepatic enzyme induction and folate metabolism. | 1 Patients on prolonged treatment with anticonvulsant and phenothiazine drugs exhibited lower than normal concentrations of folate in serum and erythrocytes, and showed increased urinary FIGLU excretion after histidine loading; urinary excretion of D-glucaric acid was also increased suggesting induction of the hepatic ... | The effects of chronic drug administration on hepatic enzyme induction and folate metabolism. 1 Patients on prolonged treatment with anticonvulsant and phenothiazine drugs exhibited lower than normal concentrations of folate in serum and erythrocytes, and showed increased urinary FIGLU excretion after histidine loading... | [
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PMID:23143 | Thermodynamics of the denaturation of pepsinogen by urea. | The denaturation of swine pepsinogen has been studied as a function of urea concentration, pH, and temperature. The unfolding of the protein by urea has been found to be fully reversible under different conditions of pH, temperature, and denaturant concentration. Kinetic experiments have shown that the transition shows... | Thermodynamics of the denaturation of pepsinogen by urea. The denaturation of swine pepsinogen has been studied as a function of urea concentration, pH, and temperature. The unfolding of the protein by urea has been found to be fully reversible under different conditions of pH, temperature, and denaturant concentration... | [
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PMID:23144 | Arginine decarboxylase from Escherichia coli B: mechanism of dissociation from the decamer to the dimer. | The mechanism by which arginine decarboxylase dissociates from a decamer to a dimer has been examined by allowing a sulfhydryl group, available in the dimer but not the decamer, to react with 5,5'-dithiobis(2-nitrobenzoic acid). Initial rates of dissociation were obtained by following the resulting increase in absorban... | Arginine decarboxylase from Escherichia coli B: mechanism of dissociation from the decamer to the dimer. The mechanism by which arginine decarboxylase dissociates from a decamer to a dimer has been examined by allowing a sulfhydryl group, available in the dimer but not the decamer, to react with 5,5'-dithiobis(2-nitrob... | [
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PMID:23145 | Mechanisms and rate equations for dissociating systems. | The results presented in the previous paper (Boeker, E.A. (1978), Biochemistry 17 (preceding paper in this issue) indicate that the dissociation of the decamer of arginine decarboxylase of Escherichia coli B is enhanced by Na+ and retarded by H+. In this system, substances which increase the rate of dissociation can be... | Mechanisms and rate equations for dissociating systems. The results presented in the previous paper (Boeker, E.A. (1978), Biochemistry 17 (preceding paper in this issue) indicate that the dissociation of the decamer of arginine decarboxylase of Escherichia coli B is enhanced by Na+ and retarded by H+. In this system, s... | [
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PMID:23151 | Transport in C4 mesophyll chloroplasts: evidence for an exchange of inorganic phosphate and phosphoenolpyruvate. | 1. Mesophyll chloroplasts of the C4 plant Digitaria sanguinalis contain endogenous phosphoenolpyruvate which appears to distribute across the envelope according to the existing pH gradient. The phosphoenolpyruvate remaining in the stroma can be rapidly released by external inorganic phosphate or 3-phosphoglycerate whil... | Transport in C4 mesophyll chloroplasts: evidence for an exchange of inorganic phosphate and phosphoenolpyruvate. 1. Mesophyll chloroplasts of the C4 plant Digitaria sanguinalis contain endogenous phosphoenolpyruvate which appears to distribute across the envelope according to the existing pH gradient. The phosphoenolpy... | [
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PMID:23152 | Pulse fluorimetry study of energy transfers between tryptophan residues and NADPH in beef liver glutamate dehydrogenase complexes. | A method is proposed to determine the rates of singlet energy transfers in an array of chromophores containing a finite number of donors and fluorescent acceptors. This method is based on measurements of transfer efficiency coupled with pulse fluorimetry. Three classes of donors can be distinguished which differ in the... | Pulse fluorimetry study of energy transfers between tryptophan residues and NADPH in beef liver glutamate dehydrogenase complexes. A method is proposed to determine the rates of singlet energy transfers in an array of chromophores containing a finite number of donors and fluorescent acceptors. This method is based on m... | [
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PMID:23153 | Effect of haemolysis on the hexose monophosphate pathway in normal and in glucose-6-phosphate dehydrogenase-deficient erythrocytes. | The hexose monophosphate pathway of human glucose-6-phosphate dehydrogenase (EC 1.1.1.49) - deficient erythrocytes is under a severe and unexplained restraint (Gaetani, G.D., Parker, J.C. and Kirkman, H.N. (1974) Proc. Natl. Acad. Sci. U.S. 71, 3584-3587). In this study the hexose monophosphate pathway activity and the... | Effect of haemolysis on the hexose monophosphate pathway in normal and in glucose-6-phosphate dehydrogenase-deficient erythrocytes. The hexose monophosphate pathway of human glucose-6-phosphate dehydrogenase (EC 1.1.1.49) - deficient erythrocytes is under a severe and unexplained restraint (Gaetani, G.D., Parker, J.C. ... | [
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PMID:23158 | Proton electrochemical gradient and phosphate potential in submitochondrial particles. | The aerobic uptake of inorganic ions, such as 86Rb+ or 125I-, by submitochondrial particles, is about one order of magnitude lower than the uptake of organic ions, such as acridines or 8-anilino-1-naphthalene sulphonate. The values of deltapH, the transmembrane pH differential, and deltapsi, the transmembrane membrane... | Proton electrochemical gradient and phosphate potential in submitochondrial particles. The aerobic uptake of inorganic ions, such as 86Rb+ or 125I-, by submitochondrial particles, is about one order of magnitude lower than the uptake of organic ions, such as acridines or 8-anilino-1-naphthalene sulphonate. The values ... | [
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PMID:23159 | Steady-state kinetics of electron transfer through cytochrome chain of uncoupled submitochondrial particles. II. Influence of pH on kinetics of electron transfer. | pH Dependences of steady-state kinetic parameters of cytochrome chains of submitochondrial particles have been studies. It has been shown that the lifetimes of activated states (tau) of the pairs of cytochromes b leads to c1 and a leads to a3 have different pH dependences; those for the c1 leads to c and c leads to a c... | Steady-state kinetics of electron transfer through cytochrome chain of uncoupled submitochondrial particles. II. Influence of pH on kinetics of electron transfer. pH Dependences of steady-state kinetic parameters of cytochrome chains of submitochondrial particles have been studies. It has been shown that the lifetimes ... | [
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PMID:23160 | Some kinetic aspects of the mechanism of hydrolysis of phosphoric acid esters by nonspecific acid phosphatase from Schizosaccharomyces pombe. | 1. The kinetics of the hydrolysis of nitrophenylphosphate by nonspecific acid phosphatase (orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2.) from Schizosaccharomices pombe was studied. 2. The kinetic parameters, Km and V, were determined as well as the inhibition constants, K1, for the inhibitors,... | Some kinetic aspects of the mechanism of hydrolysis of phosphoric acid esters by nonspecific acid phosphatase from Schizosaccharomyces pombe. 1. The kinetics of the hydrolysis of nitrophenylphosphate by nonspecific acid phosphatase (orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2.) from Schizosacc... | [
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PMID:23161 | Subunit structure and activity of glyceraldehyde-3-phosphate dehydrogenase from spinach chloroplasts. | Glyceraldehyde-phosphate dehydrogenase (D-glyceraldehyde-3-phosphate : NADP+ oxidoreductase (phosphorylating), EC 1.2.1.13) from spinach chloroplasts is a polymeric protein of approx. 600,000 daltons and sodium dodecyl sulphate gel electrophoresis shows that it consists of two subunits of molecular weight 43,000 and 37... | Subunit structure and activity of glyceraldehyde-3-phosphate dehydrogenase from spinach chloroplasts. Glyceraldehyde-phosphate dehydrogenase (D-glyceraldehyde-3-phosphate : NADP+ oxidoreductase (phosphorylating), EC 1.2.1.13) from spinach chloroplasts is a polymeric protein of approx. 600,000 daltons and sodium dodecyl... | [
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PMID:23162 | pH dependence of the kinetic parameters of L-asparaginase. | The concentration dependence of the rate of hydrolysis of L-asparagine by Escherichia coli L-asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) has been measured over the range pH 4.5 to pH 9.1 by a direct spectrophotometric assay at 220 nm and by a coupled assay utilizing glutamate dehydrogenase to detect the ammo... | pH dependence of the kinetic parameters of L-asparaginase. The concentration dependence of the rate of hydrolysis of L-asparagine by Escherichia coli L-asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) has been measured over the range pH 4.5 to pH 9.1 by a direct spectrophotometric assay at 220 nm and by a coupled... | [
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PMID:23163 | Purification and properties of asparagine synthetase from rat liver. | Asparagine synthetase (L-aspartate:ammonia ligase (AMP-forming, EC 6.3.1.1) activity in rat liver increased when the animals were put on a low casein diet. The enzyme was purified about 280-fold from the supernatant of rat liver homogenate by a procedure comprising ammonium sulfate fractionation. DEAE-Sepharose column ... | Purification and properties of asparagine synthetase from rat liver. Asparagine synthetase (L-aspartate:ammonia ligase (AMP-forming, EC 6.3.1.1) activity in rat liver increased when the animals were put on a low casein diet. The enzyme was purified about 280-fold from the supernatant of rat liver homogenate by a proced... | [
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PMID:23164 | Interaction of steroids with D-amino acid oxidase. | 1. Progesterone inhibited D-amino acid oxidase (D-amino acid : O2 oxidoreductase (deaminating), EC 1.4.3.3) in competition with its substrate, D-alanine. Binding of progesterone brought about the increase in both fluorescence intensity and fluorescence polarization of FAD, which indicates that the environment surroundi... | Interaction of steroids with D-amino acid oxidase. 1. Progesterone inhibited D-amino acid oxidase (D-amino acid : O2 oxidoreductase (deaminating), EC 1.4.3.3) in competition with its substrate, D-alanine. Binding of progesterone brought about the increase in both fluorescence intensity and fluorescence polarization of ... | [
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PMID:23165 | Enzymes of the gamma-glutamyl cycle in 'aging' WI-38 fibroblasts and in HeLa S3 cells. | gamma-Glutamyltransferase ((5-glutamyl)-peptide:amino-acid 5-glutamyltransferase, EC 2.3.2.2) activity of WI-38 fibroblasts decreased only slightly in relation to a constant amount of cell-associated protein as the cells were carried in culture serially from middle to late passage numbers leading toward senescence, e.g... | Enzymes of the gamma-glutamyl cycle in 'aging' WI-38 fibroblasts and in HeLa S3 cells. gamma-Glutamyltransferase ((5-glutamyl)-peptide:amino-acid 5-glutamyltransferase, EC 2.3.2.2) activity of WI-38 fibroblasts decreased only slightly in relation to a constant amount of cell-associated protein as the cells were carried... | [
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PMID:23167 | Tyrosine aminotransferase from chick liver. Heat activation and cold inactivation of the enzyme. | The reversible heat activation and cold inactivation of tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase, EC 2.6.1.5) of chick liver were investigated. When the enzyme obtained by gel filtration was preincubated at 37 degrees C for 10 min with 50 micrometer pyridoxal 5'-phosphate (pyridoxal-5'-P), ... | Tyrosine aminotransferase from chick liver. Heat activation and cold inactivation of the enzyme. The reversible heat activation and cold inactivation of tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase, EC 2.6.1.5) of chick liver were investigated. When the enzyme obtained by gel filtration was pre... | [
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PMID:23168 | Synthesis of acyl phosphatidylglycerol from phosphatidylglycerol in Escherichia coli K-12. Evidence for the participation of detergent-resistant phospholipase A and heat-labile membrane-bound factor(s). | The conversion of phosphatidylglycerol to acyl phosphatidylglycerol by extracts of Escherichia coli K-12 strains was examined under various conditions. The maximum rate of conversion was observed at pH 7.2 in the presence of 50% (v/v) diethyl ether and 10 mM CaCl2. This conversion was found to involve two sequential re... | Synthesis of acyl phosphatidylglycerol from phosphatidylglycerol in Escherichia coli K-12. Evidence for the participation of detergent-resistant phospholipase A and heat-labile membrane-bound factor(s). The conversion of phosphatidylglycerol to acyl phosphatidylglycerol by extracts of Escherichia coli K-12 strains was ... | [
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PMID:23169 | Cyclic peroxides from a soya lipoxygenase-catalysed oxygenation of methyl linolenate. | Incubation of methyl linolenate with an aqueous extract of soyabean flour at neutral pH gives the hydroperoxyendoperoxides 16-hydroxyperoxy-13,15-endoperoxylinolenate and 9-hydroxyperoxy-10,12-endoperoxylinolenate as the principal oxygenation products in addition to monohydroperoxides. Lipoxygenase I (EC 1.13.11.12) do... | Cyclic peroxides from a soya lipoxygenase-catalysed oxygenation of methyl linolenate. Incubation of methyl linolenate with an aqueous extract of soyabean flour at neutral pH gives the hydroperoxyendoperoxides 16-hydroxyperoxy-13,15-endoperoxylinolenate and 9-hydroxyperoxy-10,12-endoperoxylinolenate as the principal oxy... | [
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PMID:23171 | Evidence for the different responses of delta9-, delta6- and delta5-fatty acyl-CoA desaturases to cytoplasmic proteins. | Microsomes prepared from the livers of 4-week-old rats were, after extraction with 0.1 M potassium phosphate buffer, pH 7.4, unable to catalyse either the delta6 desaturation of alpha-linolenic acid (9c.12c.15c., 18 : 3) into 6c.9c.12c.15c., 18 : 4 or the delta5 desaturation of eicosatrienoic acid (8c.11c.14c., 20 : 3)... | Evidence for the different responses of delta9-, delta6- and delta5-fatty acyl-CoA desaturases to cytoplasmic proteins. Microsomes prepared from the livers of 4-week-old rats were, after extraction with 0.1 M potassium phosphate buffer, pH 7.4, unable to catalyse either the delta6 desaturation of alpha-linolenic acid (... | [
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PMID:23172 | Determination of lipoprotein-lipase activity in human skeletal muscle tissue. | An in vitro assay system was developed for the determination of lipoprotein-lipase activity in 10--30-mg specimens of human skeletal muscle tissue. The reaction medium of the assay was based on a glycine buffer of pH 8.3 (at 37 degrees C) with a heparin concentration of 1.5 g/l (about 180 IU/ml). The enzyme activity wa... | Determination of lipoprotein-lipase activity in human skeletal muscle tissue. An in vitro assay system was developed for the determination of lipoprotein-lipase activity in 10--30-mg specimens of human skeletal muscle tissue. The reaction medium of the assay was based on a glycine buffer of pH 8.3 (at 37 degrees C) wit... | [
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PMID:23173 | The activator of cerebroside-sulphatase. A model of the activation. | The activator of cereboroside-sulphatase (cerebroside-3-sulphate-3-sulphohydrolase, EC 3.1.6.8) is necessary for the enzymic hydrolysis of sulphatides (cerebroside sulphates) at ionic concentrations in the physiological range. The pH optimum of the reaction is 4.5--4.8. Under similar incubation conditions, a complex is... | The activator of cerebroside-sulphatase. A model of the activation. The activator of cereboroside-sulphatase (cerebroside-3-sulphate-3-sulphohydrolase, EC 3.1.6.8) is necessary for the enzymic hydrolysis of sulphatides (cerebroside sulphates) at ionic concentrations in the physiological range. The pH optimum of the rea... | [
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PMID:23174 | Some effects of glucose concentration and anoxia on glycolysis and metabolite concentrations in the perfused liver of fetal guinea pig. | Effects of glucose concentration and anoxia upon the metabolite concentrations and rates of glycolysis and respiration have been investigated in the perfused liver of the fetal guinea pig. In most cases the metabolite concentrations in the perfused liver were similar to those observed in vivo. Between 50 days and term ... | Some effects of glucose concentration and anoxia on glycolysis and metabolite concentrations in the perfused liver of fetal guinea pig. Effects of glucose concentration and anoxia upon the metabolite concentrations and rates of glycolysis and respiration have been investigated in the perfused liver of the fetal guinea ... | [
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PMID:23175 | A specific gastrin receptor site in the rat stomach. | A specific receptor for gastrin I has been demonstrated in the rat stomach fundus. Specific binding of 125I-labelled gastrin I was localised to particles sedimenting between 250--20 000 X g. Saturation of binding sites occurred with a gastrin concentration of 10(-11) M in an assay system containing 0.6--1.7 mg/ml of ho... | A specific gastrin receptor site in the rat stomach. A specific receptor for gastrin I has been demonstrated in the rat stomach fundus. Specific binding of 125I-labelled gastrin I was localised to particles sedimenting between 250--20 000 X g. Saturation of binding sites occurred with a gastrin concentration of 10(-11)... | [
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PMID:23176 | Effects of fatty acids on superoxide radical generation in leukocytes. | Acetylated ferricytochrome c was employed for the detection of superoxide radicals (O-2) generated both in intact cells and in subcellular fractions of leukocytes. Certain saturated fatty acids, myristate in particular, induced the production of O-2 in leukocytes, suggesting a correlation between the formation of O-2 a... | Effects of fatty acids on superoxide radical generation in leukocytes. Acetylated ferricytochrome c was employed for the detection of superoxide radicals (O-2) generated both in intact cells and in subcellular fractions of leukocytes. Certain saturated fatty acids, myristate in particular, induced the production of O-2... | [
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PMID:23177 | Interferon suppresses steroid-inducible glutamine synthetase biosynthesis in embryonic chick neural retina. | Effect of chick interferon on the biosynthesis of glutamine synthetase (L-glutamate: ammonia ligase (ADP-forming), EC 6.3.1.2) was studied in the embryonic chick neural retina cultures induced for the enzyme activity by hydrocortisone. The retinal enzyme radioactively labelled with [3H]leucine was precipitated by speci... | Interferon suppresses steroid-inducible glutamine synthetase biosynthesis in embryonic chick neural retina. Effect of chick interferon on the biosynthesis of glutamine synthetase (L-glutamate: ammonia ligase (ADP-forming), EC 6.3.1.2) was studied in the embryonic chick neural retina cultures induced for the enzyme acti... | [
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PMID:23179 | The role of ammonia, L-glutamate, and cyclic adenosine 3',5'-monophosphate in the regulation of ammonia assimilation in Rhizobium japonicum. | The effects of three factors (ammonia, L-glutamate, and cyclic adenosine 3',5'-monophosphate) on the ammonia assimilatory processes in aerobically grown Rhizobium japonicum colony derivatives were examined. Ammonia repressed glutamine synthetase activity and increased the average state of adenylylation of this enzyme. ... | The role of ammonia, L-glutamate, and cyclic adenosine 3',5'-monophosphate in the regulation of ammonia assimilation in Rhizobium japonicum. The effects of three factors (ammonia, L-glutamate, and cyclic adenosine 3',5'-monophosphate) on the ammonia assimilatory processes in aerobically grown Rhizobium japonicum colony... | [
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PMID:23180 | The proteolytic system of Penicillium roqueforti. V. -- Purification and properties of an alkaline aminopeptidase. | An alkaline aminopeptidase was isolated from the culture medium of Penicillium roqueforti. The enzyme was purified by ammonium sulfate precipitation, filtration on Bio-Gel P-100, chromatography on D.E.A.E.-cellulose and hydroxylapatite, filtration on Bio-Gel P-150 and electrofusing. The purified preparation was homogen... | The proteolytic system of Penicillium roqueforti. V. -- Purification and properties of an alkaline aminopeptidase. An alkaline aminopeptidase was isolated from the culture medium of Penicillium roqueforti. The enzyme was purified by ammonium sulfate precipitation, filtration on Bio-Gel P-100, chromatography on D.E.A.E.... | [
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PMID:23182 | [Photosynthetic electron transfer at the level of cytochrome f and plastocyanin]. | Light-induced redox conversions of cytochrome f and plastocyanin in situ and electron transporst from H2O to NADP+ were studied by a dual-wave differential spectrophotometry under identical conditions and subsequently compared. The analysis in red and far red light, treatment by inhibitors, e. g. diurone and dibromothy... | [Photosynthetic electron transfer at the level of cytochrome f and plastocyanin]. Light-induced redox conversions of cytochrome f and plastocyanin in situ and electron transporst from H2O to NADP+ were studied by a dual-wave differential spectrophotometry under identical conditions and subsequently compared. The analys... | [
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PMID:23183 | [Kinetic study of the pH-dependence of maximal rate of Ca-ATP hydrolysis by myosin]. | Curves of V pH-dependence for Ca ATPase of myosin and heavy meromyosin are demonstrated to be well modelled with theoretical curves for the case of proton dissociation at three groups of enzyme-substrate complex with the loss of the activity at some intermediate ionization stage. Variation of pK values for these three ... | [Kinetic study of the pH-dependence of maximal rate of Ca-ATP hydrolysis by myosin]. Curves of V pH-dependence for Ca ATPase of myosin and heavy meromyosin are demonstrated to be well modelled with theoretical curves for the case of proton dissociation at three groups of enzyme-substrate complex with the loss of the ac... | [
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PMID:23185 | Blockade by psychotropic drugs of the muscarinic acetylcholine receptor in cultured nerve cells. | The ability of antimuscarinics, tricyclic antidepressants, and antipsychotics to block the muscarinic acetylcholine receptor was determined using an assay for this receptor in cultured nerve cells. The technique involved the assay of receptor-mediated formation of guanosine 3',5'-cyclic phosphate (cyclic GMP) from radi... | Blockade by psychotropic drugs of the muscarinic acetylcholine receptor in cultured nerve cells. The ability of antimuscarinics, tricyclic antidepressants, and antipsychotics to block the muscarinic acetylcholine receptor was determined using an assay for this receptor in cultured nerve cells. The technique involved th... | [
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PMID:23187 | A study of the oxygenation of trochanteric bone blood and its correlation with the maximum intra-medullary pressure value in 85 cases of chronic coxopathy. | The authors carried out measurements of the gases (pH, PCO2, PO2, SaO2) on blood from the trochanter of 85 chronic hip diseases in 73 patients. Simultaneous measurements were made on the arterial blood and on the blood of the femoral vein of the same side. A statistically significant difference in blood PO2 and oxygen ... | A study of the oxygenation of trochanteric bone blood and its correlation with the maximum intra-medullary pressure value in 85 cases of chronic coxopathy. The authors carried out measurements of the gases (pH, PCO2, PO2, SaO2) on blood from the trochanter of 85 chronic hip diseases in 73 patients. Simultaneous measure... | [
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PMID:23188 | [Detection of a new anomalous variant of glucose-6-phosphate dehydrogenase in human erythrocytes]. | Kinetic and electrophoretic properties of 230--300 fold purified preparations of glucose-6-phosphate dehydrogenase (G6PD) from red cells of donors and patients with acute drug hemolytic anemia due to G6PD deficiency were studied. A new abnormal variant of G6PD isolated from red cell of a patient with acute drug hemolyt... | [Detection of a new anomalous variant of glucose-6-phosphate dehydrogenase in human erythrocytes]. Kinetic and electrophoretic properties of 230--300 fold purified preparations of glucose-6-phosphate dehydrogenase (G6PD) from red cells of donors and patients with acute drug hemolytic anemia due to G6PD deficiency were ... | [
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PMID:23191 | The beta-adrenoceptor stimulant properties of OPC-2009 on guinea-pig isolated tracheal, right atrial and left atrial preparations. | 1. The beta-adrenoceptor stimulant properties of 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxy-carbostyril hydrochloride hemihydrate (OPC-2009) were compared with those of isoprenaline and salbutamol on guinea-pig isolated tissues. 2. In producing tracheal relaxation, OPC-2009 was approximately 7 times more potent and ... | The beta-adrenoceptor stimulant properties of OPC-2009 on guinea-pig isolated tracheal, right atrial and left atrial preparations. 1. The beta-adrenoceptor stimulant properties of 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxy-carbostyril hydrochloride hemihydrate (OPC-2009) were compared with those of isoprenaline and ... | [
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... |
PMID:23189 | The action of hypercapnia during hypoxia on pulmonary vessels. | Two opposing actions of CO2 on pulmonary vessels, vasoconstriction and vasodilatation, were studied in dogs, cats, ferrets and rats using isolated lungs or a lobe of lung in vivo. Both preparations were perfused at a constant flow rate so that changes in inflow pressure at constant outflow pressure represented changes ... | The action of hypercapnia during hypoxia on pulmonary vessels. Two opposing actions of CO2 on pulmonary vessels, vasoconstriction and vasodilatation, were studied in dogs, cats, ferrets and rats using isolated lungs or a lobe of lung in vivo. Both preparations were perfused at a constant flow rate so that changes in in... | [
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PMID:23192 | Inhibitory effects of clonidine on responses to sympathetic nerve stimulation in the pithed rat. | 1. The spinal sympathetic outflow to the eyelid, heart, splanchnic blood vessels, vas deferens and anococcygeus muscle was stimulated in pithed rats. 2. Clonidine inhibited sympathetic outflow to all of the tissues studied. The inhibitory effects of clonidine on cardiac nerves and hypogastric nerves were antagonized by... | Inhibitory effects of clonidine on responses to sympathetic nerve stimulation in the pithed rat. 1. The spinal sympathetic outflow to the eyelid, heart, splanchnic blood vessels, vas deferens and anococcygeus muscle was stimulated in pithed rats. 2. Clonidine inhibited sympathetic outflow to all of the tissues studied.... | [
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PMID:23193 | Evidence for the role of adrenocortical hormones in the regulation of noradrenaline and dopamine metabolism in certain brain areas. | 1 Bilateral adrenalectomy suppressed body growth and increased the activity of tyrosine hydroxylase in rat striatum in a time-dependent manner. Fifteen days after adrenalectomy, the concentrations of noradrenaline were decreased significantly in hypothalamus and striatum, as were those of dopamine in brain stem and str... | Evidence for the role of adrenocortical hormones in the regulation of noradrenaline and dopamine metabolism in certain brain areas. 1 Bilateral adrenalectomy suppressed body growth and increased the activity of tyrosine hydroxylase in rat striatum in a time-dependent manner. Fifteen days after adrenalectomy, the concen... | [
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PMID:23194 | alpha-Adrenoceptors in the mouse vas deferens and their effects on its response to electrical stimulation. | 1 Noradrenaline (ID50, 0.75 micrometer) and clonidine (ID50, 2.8 nM) produced a dose-related inhibition of the twitch response of the isolated vas deferens of the mouse to electrical stimulation, their effectiveness decreasing as frequency of stimulation increased from 0.2 to 16 hertz. 2 Phenylephrine (1.0--2.0 microme... | alpha-Adrenoceptors in the mouse vas deferens and their effects on its response to electrical stimulation. 1 Noradrenaline (ID50, 0.75 micrometer) and clonidine (ID50, 2.8 nM) produced a dose-related inhibition of the twitch response of the isolated vas deferens of the mouse to electrical stimulation, their effectivene... | [
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PMID:23195 | The role of social anxiety in social interaction difficulties. | Social anxiety was found to be the most common complaint in a sample of psychiatric patients reporting social interaction difficulties. High social anxiety was shown to be associated with impairments to social behaviour in socially anxious psychiatric patients and non-psychiatric volunteers. A comparison was made of sy... | The role of social anxiety in social interaction difficulties. Social anxiety was found to be the most common complaint in a sample of psychiatric patients reporting social interaction difficulties. High social anxiety was shown to be associated with impairments to social behaviour in socially anxious psychiatric patie... | [
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PMID:23196 | The effect of temperature on the motility and viability of sperm. | In specimens of semen kept at 37 degrees C sperm lose their motility and viability. If kept at 4 degrees C they retain their viability but lose their motility from so-called thermal shock. The best temperature to keep semen in order to preserve sperm motility is 20 degrees C. Loss of motility at 37 degrees C is not ent... | The effect of temperature on the motility and viability of sperm. In specimens of semen kept at 37 degrees C sperm lose their motility and viability. If kept at 4 degrees C they retain their viability but lose their motility from so-called thermal shock. The best temperature to keep semen in order to preserve sperm mot... | [
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PMID:23197 | Antinuclear antibodies in patients receiving non-practolol beta-blockers. | Antinuclear antibodies (ANA) were found in 54 (7.0%) out of 767 treated hypertensive patients compared with 59 (2.4%) out of 2470 healthy controls. Inclusion of a non-practolol beta-blocker in the treatment regimen did not significantly affect the incidence of ANA. ANA was found in significantly more patients being tre... | Antinuclear antibodies in patients receiving non-practolol beta-blockers. Antinuclear antibodies (ANA) were found in 54 (7.0%) out of 767 treated hypertensive patients compared with 59 (2.4%) out of 2470 healthy controls. Inclusion of a non-practolol beta-blocker in the treatment regimen did not significantly affect th... | [
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