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PMID:5827 | Reversal of dibromothymoquinone inhibition of photosynthetic electron flow by thiol compounds. | Dibromothymoquinone inhibits photosynthetic NADP reduction by broken chloroplasts. The inhibition of electron flow and coupled ATP formation is effectively reversed by the addition of thiol compounds. | Reversal of dibromothymoquinone inhibition of photosynthetic electron flow by thiol compounds. Dibromothymoquinone inhibits photosynthetic NADP reduction by broken chloroplasts. The inhibition of electron flow and coupled ATP formation is effectively reversed by the addition of thiol compounds. | [
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PMID:5828 | On the mechanism of the acridine orange sensitized photodynamic inactivation of lysozyme. I. Basic kinetics. | The kinetics of the photodynamic desactivation of lysozyme in presence of acridine orange as the sensitizer have been investigated in detail varying oxygen, protein, dye concentration, ionic strength and pH value. The kinetics can be approximately described as an over all pseudo-first-order rate process. Changing the s... | On the mechanism of the acridine orange sensitized photodynamic inactivation of lysozyme. I. Basic kinetics. The kinetics of the photodynamic desactivation of lysozyme in presence of acridine orange as the sensitizer have been investigated in detail varying oxygen, protein, dye concentration, ionic strength and pH valu... | [
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PMID:5829 | Photoreactions of cytochrome b6 and cytochrome f in chloroplast photosystem I fragments. | Photosystem I fragments were prepared by digitonin treatment of spinach chloroplasts. The midpoint potential of cytochrome b6 in the fragments is close to 0V, showing a one electron transition. No cytochrome b559 was detectable, neither in difference absorption spectra nor in light-induced absorbance changes. In the ab... | Photoreactions of cytochrome b6 and cytochrome f in chloroplast photosystem I fragments. Photosystem I fragments were prepared by digitonin treatment of spinach chloroplasts. The midpoint potential of cytochrome b6 in the fragments is close to 0V, showing a one electron transition. No cytochrome b559 was detectable, ne... | [
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PMID:5836 | [Extraction and concentration of Clostridium botulinum toxins from specimens (author's transl)]. | In order to detect minimal amounts of Clostridium botulinum toxins in animal tissue or food specimens it is necessary to use an extraction method which results in concentration of the botulinal toxins. In the present examinations, artificially contaminated canned beans were used to develop a suitable procedure for extr... | [Extraction and concentration of Clostridium botulinum toxins from specimens (author's transl)]. In order to detect minimal amounts of Clostridium botulinum toxins in animal tissue or food specimens it is necessary to use an extraction method which results in concentration of the botulinal toxins. In the present examin... | [
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PMID:5834 | Bacterial meningitis in infancy and childhood in Lusaka (One year prospective sturdy). | In approximately 10,000 admissions in a 12 months period, at University Teaching Hospital, Lusaka 85 cases of meningitis were recorded. The signs and symptoms in these patients do not greatly differ from other similar studies in Africa. The commonest organism isolated was pneumococcus. There was high mortality rate whi... | Bacterial meningitis in infancy and childhood in Lusaka (One year prospective sturdy). In approximately 10,000 admissions in a 12 months period, at University Teaching Hospital, Lusaka 85 cases of meningitis were recorded. The signs and symptoms in these patients do not greatly differ from other similar studies in Afri... | [
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PMID:5840 | Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in infants. | Cerebral blood flow (CBF) and cerebral av-differences of oxygen and circulating substrates were measured in normocapnic infants during general anaesthesia before elective surgery in order to study possible age-dependent variations. CBF was determined by a minor modification of the Kety-Schmidt technique from desaturati... | Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in infants. Cerebral blood flow (CBF) and cerebral av-differences of oxygen and circulating substrates were measured in normocapnic infants during general anaesthesia before elective surgery in order to study possible ... | [
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PMID:5841 | Down's syndrome with X0/XY mosaicism. | A 5-month-old Chinese infant with combined Down's syndrome and X0/XY mosaicism is presented. The phenotypical features of mongolism are classical and unmodified. The somatic effects of X0/XY mosaicism is that of incomplete masculinization with short phallus, hypospadias, bifid scrotum, urogenital sinus, and bilateral e... | Down's syndrome with X0/XY mosaicism. A 5-month-old Chinese infant with combined Down's syndrome and X0/XY mosaicism is presented. The phenotypical features of mongolism are classical and unmodified. The somatic effects of X0/XY mosaicism is that of incomplete masculinization with short phallus, hypospadias, bifid scro... | [
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PMID:5842 | Bile canalicular alkaline phosphatase and disease. | The alkaline phosphatase reaction is normally absent in human bile canaliculi, but was found in 79 patients. In search for a common causal factor, these patients were further examined. Thirty-seven were autopsied. The conditions most ocmmonly associated with the phenomenon were malignant tumours with or without involve... | Bile canalicular alkaline phosphatase and disease. The alkaline phosphatase reaction is normally absent in human bile canaliculi, but was found in 79 patients. In search for a common causal factor, these patients were further examined. Thirty-seven were autopsied. The conditions most ocmmonly associated with the phenom... | [
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PMID:5843 | Polyarteritis nodosa associated with nosematosis in blue foxes. | The patho-morphological lesions in fox nosematosis (encephalitozoonosis) were studied in a material comprising 150 young blue foxes from 23 different farms. Disseminated nosematosis in blue fox pups was regularly accompanied by severe vasculitis, affecting medium-sized and small arteries in various organs. The acute da... | Polyarteritis nodosa associated with nosematosis in blue foxes. The patho-morphological lesions in fox nosematosis (encephalitozoonosis) were studied in a material comprising 150 young blue foxes from 23 different farms. Disseminated nosematosis in blue fox pups was regularly accompanied by severe vasculitis, affecting... | [
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PMID:5844 | Some factors influencing the haemolysis of Bordetella bronchiseptica. | Strain-dependent variations in the ability of Bordetella bronchiseptica to produce haemolysis on solid media exist. Haemolysis is strongest at an acid reaction and will not take place if the reaction is too alkaline. Peptone and glutamine inhibit haemolysis and favour growth. The vigorous growth rapidly produced an alk... | Some factors influencing the haemolysis of Bordetella bronchiseptica. Strain-dependent variations in the ability of Bordetella bronchiseptica to produce haemolysis on solid media exist. Haemolysis is strongest at an acid reaction and will not take place if the reaction is too alkaline. Peptone and glutamine inhibit hae... | [
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PMID:5845 | [Effects of acid-base changes upon the chronotropic response to norepinephrine (author's transl)]. | The effect of changes in pH produced by changing NaHCO2 at constant pCO2 and by changing pCO2 at constant NaHCO2 concentration was studied in the spontaneous beating rat atrium. Alkalosis produced either by changes in pCO2 or in NaHCO2 concentration increased basal heart rate shifting dose-response curves to norepineph... | [Effects of acid-base changes upon the chronotropic response to norepinephrine (author's transl)]. The effect of changes in pH produced by changing NaHCO2 at constant pCO2 and by changing pCO2 at constant NaHCO2 concentration was studied in the spontaneous beating rat atrium. Alkalosis produced either by changes in pCO... | [
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PMID:5846 | Blood changes in water deprived rats. | To study the variations of blood constituents during water deprivation, rats were deprived of water from six to twelve days. Control and rehydrated animals were also included in the study. A significant increase was observed in sodium, chloride and hematocrit throughout the experiment. Calcium, bicarbonate and PCO2 inc... | Blood changes in water deprived rats. To study the variations of blood constituents during water deprivation, rats were deprived of water from six to twelve days. Control and rehydrated animals were also included in the study. A significant increase was observed in sodium, chloride and hematocrit throughout the experim... | [
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PMID:5848 | Effect of ultraviolet radiation on pinocytosis in Amoeba proteua. | Ultraviolet (UV) irradiation (4 000-10 000 erg X mm(-2) decreased membrane potential and input resistance of Amoeba proteus and induced formation of pinocytotic channels. Submaximal pinocytosis induced by UV light was additive to pinocytosis induced by K+ or Na+ and stimulated in the presence of EGTA. It was not inhibi... | Effect of ultraviolet radiation on pinocytosis in Amoeba proteua. Ultraviolet (UV) irradiation (4 000-10 000 erg X mm(-2) decreased membrane potential and input resistance of Amoeba proteus and induced formation of pinocytotic channels. Submaximal pinocytosis induced by UV light was additive to pinocytosis induced by K... | [
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PMID:5849 | An in vitro-formed protamine-heparin complex as a model for a two-compartment store for biogenic amines. | The capacity of an in vitro-formed protamine-heparin complex (PHC) to store inorganic cations and biogenic amines was investigated. The PHC behaves like a two-compartment storage system. One compartment corresponds to the terminal free carboxyl groups of the protamine moiety and has the characteristics of a cation exch... | An in vitro-formed protamine-heparin complex as a model for a two-compartment store for biogenic amines. The capacity of an in vitro-formed protamine-heparin complex (PHC) to store inorganic cations and biogenic amines was investigated. The PHC behaves like a two-compartment storage system. One compartment corresponds ... | [
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PMID:5847 | The local effect of pH changes in the cerebrospinal fluid on the ventrolateral areas of medulla oblongata and on the spinal cord surface on the activity of cardiac and vertebral sympathetic nerves. | Application of acid cerebrospinal fluid at pH 6.8 to the ventral surface of the medulla oblongata in cats increased the arterial blood pressure and the activity of the vertebral nerve and enhanced respiratory modulation of the vertebral and cardiac nerves. Alkaline cerebrospinal fluid at pH 7.7 applied to the ventral s... | The local effect of pH changes in the cerebrospinal fluid on the ventrolateral areas of medulla oblongata and on the spinal cord surface on the activity of cardiac and vertebral sympathetic nerves. Application of acid cerebrospinal fluid at pH 6.8 to the ventral surface of the medulla oblongata in cats increased the ar... | [
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PMID:5850 | Oxygen uptake and tissue oxygen tension during adrenergic stimulation in canine subcutaneous adipose tissue. | The effect of sympathetic nerve stimulation (NS) and injected noradenaline (NA) or isoprenaline (Iso) on PVO2, VO2 and PtO2 was studied in isolated canine subcutaneous adipose tissue. These effects were compared to those produced by mechanical blood flow reduction (clamping). Resting VO2 measured 13.0+/- 2.3 mumol X mi... | Oxygen uptake and tissue oxygen tension during adrenergic stimulation in canine subcutaneous adipose tissue. The effect of sympathetic nerve stimulation (NS) and injected noradenaline (NA) or isoprenaline (Iso) on PVO2, VO2 and PtO2 was studied in isolated canine subcutaneous adipose tissue. These effects were compared... | [
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PMID:5851 | Beta2-adrenoceptors facilitating noradrenaline secretion from human vasoconstrictor nerves. | Isolated biopsy specimens of human peripheral arteries and veins, preincubated with 3H-(-)- noradrenaline (NA) to label the neural stores of NA, were used to study the Beta-adrenoceptors previously found to increase the secretion of 3H-NA evoked by electrical field stimulation of the adrenergic nerves of this tissue. T... | Beta2-adrenoceptors facilitating noradrenaline secretion from human vasoconstrictor nerves. Isolated biopsy specimens of human peripheral arteries and veins, preincubated with 3H-(-)- noradrenaline (NA) to label the neural stores of NA, were used to study the Beta-adrenoceptors previously found to increase the secretio... | [
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PMID:5852 | Vagal reflexes in the bronchoconstriction occurring after induced intravascular platelet aggregation. | Intravascular platelet aggregation induced in cats by i.v. infusions of collagen caused a transient increase in pulmonary vascular resistance (PVR) and in non-elastic pulmonary resistance (RL), and a transient decrease in dynamic lung compliance (dyn CL). PVR,dyn CL and platelet aggregation after collagen infusions wer... | Vagal reflexes in the bronchoconstriction occurring after induced intravascular platelet aggregation. Intravascular platelet aggregation induced in cats by i.v. infusions of collagen caused a transient increase in pulmonary vascular resistance (PVR) and in non-elastic pulmonary resistance (RL), and a transient decrease... | [
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PMID:5853 | Clinical features in poisonings by tricyclic antidepressants with special reference to the ECG. | Clinical variables, and especially their relation to the ECG, have been studied in 153 cases of poisonings by tricyclic antidepressants (TCA). The mean age of the patients was 34 years. Amitriptyline poisoning accounted for 112 (73%) of the cases and the mean dose ingested was about 1 000 mg. Coma was present in 87 pat... | Clinical features in poisonings by tricyclic antidepressants with special reference to the ECG. Clinical variables, and especially their relation to the ECG, have been studied in 153 cases of poisonings by tricyclic antidepressants (TCA). The mean age of the patients was 34 years. Amitriptyline poisoning accounted for ... | [
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PMID:5854 | The mechanism of action of glycosidases. | The factors that may contribute to the rate enhancement observed with enzymatic versus non-enzymatic hydrolysis of glycosides are discussed. The nature of the active site as deduced from labelling studies with beta-glucosidases is described. A two-step mechanism involving either an enzyme stabilized glycosyl ion or a c... | The mechanism of action of glycosidases. The factors that may contribute to the rate enhancement observed with enzymatic versus non-enzymatic hydrolysis of glycosides are discussed. The nature of the active site as deduced from labelling studies with beta-glucosidases is described. A two-step mechanism involving either... | [
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PMID:5855 | Properties of hydroxysteroid oxidoreductase isolated from yeast. | Yeasts can advantageously be utilized for the production of the 17beta-hydroxy-derivative, from 3-methoxy-8,14-seco-1,3,5(10),9(11)-estratetraene-14,17-dione (14,17-dione) while 14alpha-hydroxy and 14alpha,17beta-dihydroxy-derivatives are also formed. The biochemical properties of yeasts' enzymes responsible for the fo... | Properties of hydroxysteroid oxidoreductase isolated from yeast. Yeasts can advantageously be utilized for the production of the 17beta-hydroxy-derivative, from 3-methoxy-8,14-seco-1,3,5(10),9(11)-estratetraene-14,17-dione (14,17-dione) while 14alpha-hydroxy and 14alpha,17beta-dihydroxy-derivatives are also formed. The... | [
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PMID:5856 | Properties of delta5-3beta-hydroxysteroid oxidoreductase isolated from Streptomyces griseocarneus. | Delta5-3beta-hydroxysteroid oxidoreductase was extracted in magnesium-containing Tris buffer from sonicated Streptomyces griseocarneus cells. The enzyme was partially purified (150 X) by ion exchange chromatography and gel filtration following (NH4)2SO4 fractionation. Upon gel filtration on Sephadex G-75 to G-200, the ... | Properties of delta5-3beta-hydroxysteroid oxidoreductase isolated from Streptomyces griseocarneus. Delta5-3beta-hydroxysteroid oxidoreductase was extracted in magnesium-containing Tris buffer from sonicated Streptomyces griseocarneus cells. The enzyme was partially purified (150 X) by ion exchange chromatography and ge... | [
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PMID:5857 | Soil microflora of the rhizosphere of plants from several habitats in the botanical garden in Poznań. | The abundance and activity of certain groups of soil microorganisms were estimated in the rhizosphere of 13 plants from four different habitats at several dates. An additional study was made of the rhizosphere microflora of Ledum palustre from a peat-bog. Numbers of proteolytic, nitrate assimilating, denitrifying, and ... | Soil microflora of the rhizosphere of plants from several habitats in the botanical garden in Poznań. The abundance and activity of certain groups of soil microorganisms were estimated in the rhizosphere of 13 plants from four different habitats at several dates. An additional study was made of the rhizosphere microflo... | [
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PMID:5858 | Kinetic studies on citric acid production by Aspergillus niger. II. The two-stage process. | A two-stage process of submerged citric acid fermentation with replacement of growth medium by fermentation medium has been worked out. The optimum composition of mineral nutrients and pH of the fermentation medium of the second stage of the process were determined. An addition of 0.5 g/l of NH4NO3 as nitrogen source a... | Kinetic studies on citric acid production by Aspergillus niger. II. The two-stage process. A two-stage process of submerged citric acid fermentation with replacement of growth medium by fermentation medium has been worked out. The optimum composition of mineral nutrients and pH of the fermentation medium of the second ... | [
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PMID:5859 | L-Glutamate-glyoxylate aminotransferase in Lactobacillus plantarum. | Glutamate-glyoxylate aminotransferase which mediates the reaction of glyoxylic acid with glutamic acid to yield glycine and alpha-oxoglutaric acid has been isolated and purified 84-fold from extracts of Lactobacillus plantarum. Purified enzyme requires the addition of pyridoxal phosphate and magnesium ions for its acti... | L-Glutamate-glyoxylate aminotransferase in Lactobacillus plantarum. Glutamate-glyoxylate aminotransferase which mediates the reaction of glyoxylic acid with glutamic acid to yield glycine and alpha-oxoglutaric acid has been isolated and purified 84-fold from extracts of Lactobacillus plantarum. Purified enzyme requires... | [
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PMID:5863 | Inhibition of Newcastle disease virus replication by 6-azauridine. II. Combination of 6-azauridine and adenine derivatives. | Twenty-five metabolites (purines, pyrimidines, nucleosides and nucleosides) were tested for their simultaneous action with 6-azauridine (AzUrd) in inhibition of Newcastle disease virus (NDV) replication. With the exception of deoxyadenosine and cyclic AMP all natural adenine derivatives exerted a synergic effect with A... | Inhibition of Newcastle disease virus replication by 6-azauridine. II. Combination of 6-azauridine and adenine derivatives. Twenty-five metabolites (purines, pyrimidines, nucleosides and nucleosides) were tested for their simultaneous action with 6-azauridine (AzUrd) in inhibition of Newcastle disease virus (NDV) repli... | [
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PMID:5864 | Some biological activities of rabbit anti-interferon serum. | After prolonged immunization of rabbits with a semipurified mouse interferon preparation in Freund's incomplete or Al-Span-Oil adjuvant, a specific interferon-neutralizing immunoglobulin was obtained from antiserum with a capacity of neutralizing about 49000 mouse interferon units per ml. The specific activity of the a... | Some biological activities of rabbit anti-interferon serum. After prolonged immunization of rabbits with a semipurified mouse interferon preparation in Freund's incomplete or Al-Span-Oil adjuvant, a specific interferon-neutralizing immunoglobulin was obtained from antiserum with a capacity of neutralizing about 49000 m... | [
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PMID:5865 | Interferon-producing capacity of human tonsil cells and properties of interferon produced by these cells. | Tonsils excised from human beings for chronic tonsillitis have been shown to be an accessible and sufficiently rich source of human lymphocytes. Tonsil cells produced interferon as intensively as blood leukocytes and the properties of this interferon were similar to those of leukocyte interferon. The optimal conditions... | Interferon-producing capacity of human tonsil cells and properties of interferon produced by these cells. Tonsils excised from human beings for chronic tonsillitis have been shown to be an accessible and sufficiently rich source of human lymphocytes. Tonsil cells produced interferon as intensively as blood leukocytes a... | [
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PMID:5866 | Diminished virucidal activity of kethoxal against vesicular stomatitis virus pretreated with guanidinating reagent and proteases. | The reactivity of vesicular stomatitis virus (VSV) with kethoxal can be appreciably altered by treatment with 1-guanyl-3, 5-dimethyl pyrazole nitrate (GDMP) and proteolytic enzymes. Pretreatment of purified VSV with GDMP or proteolytic enzymes markedly reduced the effectiveness of kethoxal as a virucide. The rate of ne... | Diminished virucidal activity of kethoxal against vesicular stomatitis virus pretreated with guanidinating reagent and proteases. The reactivity of vesicular stomatitis virus (VSV) with kethoxal can be appreciably altered by treatment with 1-guanyl-3, 5-dimethyl pyrazole nitrate (GDMP) and proteolytic enzymes. Pretreat... | [
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PMID:5867 | Levels of immunoglobulins and antibodies to haemaglutinin and neuraminidase of influenza virus in nasal secretions after natural infection. | Nasal washings (NW) from 16 influenza patients in the course of an epidemic in November and December, 1974 were examined for the presence of influenza virus, immunoglobulins (Ig) and titres of haemagglutination inhibiting (HI) and neuraminidase inhibiting (NI) antibodies. Influenza virus identical with A/Port Chalmers/... | Levels of immunoglobulins and antibodies to haemaglutinin and neuraminidase of influenza virus in nasal secretions after natural infection. Nasal washings (NW) from 16 influenza patients in the course of an epidemic in November and December, 1974 were examined for the presence of influenza virus, immunoglobulins (Ig) a... | [
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PMID:5868 | Associated seroconversions to respiratory viruses in volunteers with experimental influenza infection. | Serological examinations of 573 volunteers with mild experimental influenza infection and 86 volunteers of a control group hospitalized in a special clinic revealed a significant rise in the titre of antibodies (seroconversion) not only to influenza A or B viruses used for the experimental infection but in 23.3 to 29.8... | Associated seroconversions to respiratory viruses in volunteers with experimental influenza infection. Serological examinations of 573 volunteers with mild experimental influenza infection and 86 volunteers of a control group hospitalized in a special clinic revealed a significant rise in the titre of antibodies (seroc... | [
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PMID:5869 | Different allotypic susceptibility of mice to Rickett-sia tsutsugamushi. | Some lines of mice and random-bred mice show different susceptibility to infection with Rickettsia tsutsugamushi, displayed mainly in the development of overt infection. The latter is most markedly manifested in random-bred and Swiss mice, causing high death rates and massive accumulation of rickettsiae in the peritone... | Different allotypic susceptibility of mice to Rickett-sia tsutsugamushi. Some lines of mice and random-bred mice show different susceptibility to infection with Rickettsia tsutsugamushi, displayed mainly in the development of overt infection. The latter is most markedly manifested in random-bred and Swiss mice, causing... | [
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PMID:5870 | Cytological investigation of Rickettsia tsutsugamushi infection of mice with different allotypic susceptibility to the agent. | Cytological and cytochemical studies on Swiss and random-bred white mice susceptible to Rickettsia tsutsugamushi infection as well as resistant C57 Black 6 and CBA mice revealed a clear-cut relationship between the severity of infection and the pattern of macrophage reaction. In highly susceptible mice the fatal infect... | Cytological investigation of Rickettsia tsutsugamushi infection of mice with different allotypic susceptibility to the agent. Cytological and cytochemical studies on Swiss and random-bred white mice susceptible to Rickettsia tsutsugamushi infection as well as resistant C57 Black 6 and CBA mice revealed a clear-cut rela... | [
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PMID:5871 | Characterization of an endotoxic lipopolysaccharide from Coxiella burnetii. | Phase I Coxiella burnetii antigen isolated by phenol extraction from purified suspensions of C. burnetii in phase I is a complex lipopolysaccharide (LPS) molecule containing substances typical of the bacterial LPS. Some endotoxic properties of this C. burnetii LPS, namely pyrogenicity and skin epinephrine reaction in r... | Characterization of an endotoxic lipopolysaccharide from Coxiella burnetii. Phase I Coxiella burnetii antigen isolated by phenol extraction from purified suspensions of C. burnetii in phase I is a complex lipopolysaccharide (LPS) molecule containing substances typical of the bacterial LPS. Some endotoxic properties of ... | [
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PMID:5872 | Electron microscopy of virus particles in ultrathin frozen sections. | A procedure with the use of polyethylene glycol (PEG) 600 to support biological materials for ultracryotomy was developed. Developing and mature virions were demonstrated by electron microscopy in negatively stained frozen sections of vaccinia virus-infected human diploid cells and of herpes simplex virus (HSV) type 1 ... | Electron microscopy of virus particles in ultrathin frozen sections. A procedure with the use of polyethylene glycol (PEG) 600 to support biological materials for ultracryotomy was developed. Developing and mature virions were demonstrated by electron microscopy in negatively stained frozen sections of vaccinia virus-i... | [
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PMID:5873 | Interferon pretreatment primes interferon production by human adenovirus in chick embryo cells. | Pretreatment of chick embryo cells (CEC) with homologous interferon enhanced the subsequent interferon production induced by human adenovirus. This priming effect of interferon pretreatment was also demonstrable when trypsin-treated virus was used for the induction of interferon. | Interferon pretreatment primes interferon production by human adenovirus in chick embryo cells. Pretreatment of chick embryo cells (CEC) with homologous interferon enhanced the subsequent interferon production induced by human adenovirus. This priming effect of interferon pretreatment was also demonstrable when trypsin... | [
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PMID:5874 | Enhancement of interferon induction in mice by polycationic modified polypeptides. | Combined intraperitoneal treatment of mice with poly I: C and a polycationic modified polypeptide (poly-DMAE-glutamine) was investigated. It was established that the presence of appropriate amounts of poly-DMAE-glutamine produced markedly enhanced serum interferon levels as compared to those produced by poly I: C alone... | Enhancement of interferon induction in mice by polycationic modified polypeptides. Combined intraperitoneal treatment of mice with poly I: C and a polycationic modified polypeptide (poly-DMAE-glutamine) was investigated. It was established that the presence of appropriate amounts of poly-DMAE-glutamine produced markedl... | [
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PMID:5878 | Inhibition of Newcastle disease virus replication by 6-azauridine. I. Inefficacy of purified uridine kinase, effect of adenosine-5'-triphosphate. | As distinct from cell-free extracts prepared from tumour cells, partially purified uridine kinase prepared from the same cells was not effective in 6-azauridine (AzUrd) inhibition of Newcastle disease virus (NDV) replication. This showed that uridine kinase was not the effective component of cell-free extracts. Adenosi... | Inhibition of Newcastle disease virus replication by 6-azauridine. I. Inefficacy of purified uridine kinase, effect of adenosine-5'-triphosphate. As distinct from cell-free extracts prepared from tumour cells, partially purified uridine kinase prepared from the same cells was not effective in 6-azauridine (AzUrd) inhib... | [
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PMID:5880 | Effect of vagus nerve stimulation upon excitability of the canine ventricle. Role of sympathetic-parasympathetic interactions. | The effect of vagus nerve stimulation on ventricular excitability was studied in 28 dogs under various conditions of adrenergic neural tone. Strength-interval curves were delineated from the apex of the right ventricular endocardium with a transvenous bipolar catheter. Vagus nerve stimulation in both closed chest and o... | Effect of vagus nerve stimulation upon excitability of the canine ventricle. Role of sympathetic-parasympathetic interactions. The effect of vagus nerve stimulation on ventricular excitability was studied in 28 dogs under various conditions of adrenergic neural tone. Strength-interval curves were delineated from the ap... | [
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PMID:5881 | An automated flavin adenine dinucleotide-dependent glutathione reductase assay for assessing riboflavin nutriture. | An automated AutoAnalyzer method using 5:5'-dithiobis-2-nitrobenzoic acid is described for determining whole blood glutathione reductase (BGR) activity and for measuring in vitro activation of BGR with flavin adenine dinucleotide (FAD). BGR activity is expressed as mumoles glutathione regenerated from oxidized glutathi... | An automated flavin adenine dinucleotide-dependent glutathione reductase assay for assessing riboflavin nutriture. An automated AutoAnalyzer method using 5:5'-dithiobis-2-nitrobenzoic acid is described for determining whole blood glutathione reductase (BGR) activity and for measuring in vitro activation of BGR with fla... | [
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PMID:5882 | Accidental poisoning with psychotropic drugs in children. | Seventy-seven (0.24%) of 32,005 admissions to the Massachusetts General Hospital pediatric service during the period 1962 to 1973 were due to accidental poisoning. In 27 cases, mostly involving children less than 6 years of age, psychotropic drugs were implicated. These included sedative-hypnotics in six cases, phenyto... | Accidental poisoning with psychotropic drugs in children. Seventy-seven (0.24%) of 32,005 admissions to the Massachusetts General Hospital pediatric service during the period 1962 to 1973 were due to accidental poisoning. In 27 cases, mostly involving children less than 6 years of age, psychotropic drugs were implicate... | [
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PMID:5879 | [Mediators of the allergic reaction. Slow reacting substance (SRS-A)]. | The slow reacting substance of anaphylaxis (SRS-A) belongs to a group of substances which produce a slow progressive and sustained contraction of some smooth muscles. It is released by the interaction of the antigen with certain antibodies; in humans through the interaction with the IgE or reagine. The SRS-A is a heat-... | [Mediators of the allergic reaction. Slow reacting substance (SRS-A)]. The slow reacting substance of anaphylaxis (SRS-A) belongs to a group of substances which produce a slow progressive and sustained contraction of some smooth muscles. It is released by the interaction of the antigen with certain antibodies; in human... | [
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PMID:5883 | Polyarteritis in children. | Polyarteritis was diagnosed in three girls, 9 to 10 years old, by kidney and skin biopsies. They were treated with a combination of prednisone (1.5 to 2 mg/kg) and cyclophosphamide (2 mg/kg) for up to 12 months. The illness was severe in all three, complicated by hypertension, seizures, pulmonary infiltrates, renal fai... | Polyarteritis in children. Polyarteritis was diagnosed in three girls, 9 to 10 years old, by kidney and skin biopsies. They were treated with a combination of prednisone (1.5 to 2 mg/kg) and cyclophosphamide (2 mg/kg) for up to 12 months. The illness was severe in all three, complicated by hypertension, seizures, pulmo... | [
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PMID:5885 | Changes in mucosal and venous histamine concentrations during instillation of ethanol in the canine stomach. | Histamine concentrations in the gastric mucosa, gastric vein blood, and gastric contents were measured after instillation of 300 ml of 40%, 20% and 12.5%, vol/vol, ethanol intragastrically for 30 min in anesthetized dogs. The mean histamine concentration in the gastric mucosa, gastric vein blood, and gastric contents i... | Changes in mucosal and venous histamine concentrations during instillation of ethanol in the canine stomach. Histamine concentrations in the gastric mucosa, gastric vein blood, and gastric contents were measured after instillation of 300 ml of 40%, 20% and 12.5%, vol/vol, ethanol intragastrically for 30 min in anesthet... | [
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PMID:5886 | Organic anions induce colinic secretion. | Experiments were conducted by instilling test solutions into the cleaned colon of anesthetized rats. Isotonic test solutions at an acid (2.9% or neutral (7.0) pH and containing acetic acid or acetate ions were used. At the lower pH, acetic acid was absorbed well absorbed and the colon absorbed fluid. The secretory effe... | Organic anions induce colinic secretion. Experiments were conducted by instilling test solutions into the cleaned colon of anesthetized rats. Isotonic test solutions at an acid (2.9% or neutral (7.0) pH and containing acetic acid or acetate ions were used. At the lower pH, acetic acid was absorbed well absorbed and the... | [
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PMID:5888 | Residues in antibiotic preparations, i: scanning electron microscopic studies of surface topography. | The surface characteristics of residues obtained from several commercial antibiotic products were studied using scanning electron microscopy. The photomicrographs showed the presence of particulates possessing crystalline or amorphous properties with particle sizes ranging from 1 mum to several mum. Small, well-defined... | Residues in antibiotic preparations, i: scanning electron microscopic studies of surface topography. The surface characteristics of residues obtained from several commercial antibiotic products were studied using scanning electron microscopy. The photomicrographs showed the presence of particulates possessing crystalli... | [
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PMID:5889 | Residues in antibiotic preparations, ii: effect of pH on the nature and level of particulate matter in sodium cephalothin intravenous solutions. | The effect of pH on the extent and nature of particulate contamination in sodium cephalothin intravenous solutions was studied. The extent of particulate contamination was determined by microscopic and automatic electronic counting procedures, and the physical nature of the particles was determined using scanning elect... | Residues in antibiotic preparations, ii: effect of pH on the nature and level of particulate matter in sodium cephalothin intravenous solutions. The effect of pH on the extent and nature of particulate contamination in sodium cephalothin intravenous solutions was studied. The extent of particulate contamination was det... | [
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PMID:5890 | Compatibility of penicillin and ascorbic acid injection. | The stability of Potassium Penicillin G, USP, when mixed with Ascorbic Acid Injection, USP, in 5% Dextrose Injection, USP, was studied. The change in concentration over an eight-hour period of potassium penicillin G in the admixture was determined by the hydroxylamine colorimetric assay method and the microbiological a... | Compatibility of penicillin and ascorbic acid injection. The stability of Potassium Penicillin G, USP, when mixed with Ascorbic Acid Injection, USP, in 5% Dextrose Injection, USP, was studied. The change in concentration over an eight-hour period of potassium penicillin G in the admixture was determined by the hydroxyl... | [
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PMID:5892 | Self-injurious behavior in schizophrenic and retarded children. | Self-injurious behavior is a problem with some children who are primarily nonverval and low-functioning. This behavior has resulted in management difficulties far out of proportion to its incidence. In the present paper, we have considered possible operant and respondent paradigms instrumental in the acquisition and m... | Self-injurious behavior in schizophrenic and retarded children. Self-injurious behavior is a problem with some children who are primarily nonverval and low-functioning. This behavior has resulted in management difficulties far out of proportion to its incidence. In the present paper, we have considered possible operan... | [
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PMID:5893 | Fetal acid-base balance. I. Interdependence of maternal and fetal PCO2 and bicarbonate concentration. | This paper presents the results of measurements of the acid-base and gaseous status of maternal and fetal capillary blood at the time of amniotomy, before the onset of labor. The correlation coefficient between maternal and fetal bicarbonate concentration is 0.6, and that between maternal and fetal PCO2 is 0.31. From t... | Fetal acid-base balance. I. Interdependence of maternal and fetal PCO2 and bicarbonate concentration. This paper presents the results of measurements of the acid-base and gaseous status of maternal and fetal capillary blood at the time of amniotomy, before the onset of labor. The correlation coefficient between materna... | [
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PMID:5894 | Breathing patterns before death in fetal lambs. | Continuous observations in 16 fetal lambs over many days before death in utero from hypoxia, asphyxia, infection, and other causes have shown that death is preceded by variable changes in breathing movements. There was always a prolonged period of apnea succeeded by continuous abnormal breathing in six lambs and by gas... | Breathing patterns before death in fetal lambs. Continuous observations in 16 fetal lambs over many days before death in utero from hypoxia, asphyxia, infection, and other causes have shown that death is preceded by variable changes in breathing movements. There was always a prolonged period of apnea succeeded by conti... | [
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PMID:5895 | The evaluation of continuous fetal heart rate monitoring in high-risk pregnancy. | Intrapartum electronic fetal heart rate monitoring of the high-risk obstetric patient is thought to improve the perinatal outcome. A prospective randomized study of 483 high-risk obstetric patients in labor was carried out comparing the effectiveness of electronic fetal monitoring with auscultation of fetal heart tones... | The evaluation of continuous fetal heart rate monitoring in high-risk pregnancy. Intrapartum electronic fetal heart rate monitoring of the high-risk obstetric patient is thought to improve the perinatal outcome. A prospective randomized study of 483 high-risk obstetric patients in labor was carried out comparing the ef... | [
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PMID:5896 | Evaluation of redox state of isolated perfused rat lung. | The metabolic responsiveness of lung tissue to inhibition of oxidative metabolism was determined by measurement of the redox state of the isolated perfused and ventilated rat lung. Changes in redox state were evaluated by fluorescence from the lung surface at wavelengths suitable for reduced pyridine nucleotides and by... | Evaluation of redox state of isolated perfused rat lung. The metabolic responsiveness of lung tissue to inhibition of oxidative metabolism was determined by measurement of the redox state of the isolated perfused and ventilated rat lung. Changes in redox state were evaluated by fluorescence from the lung surface at wav... | [
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PMID:5897 | Altered hepatic glycogen metabolism and glucoregulatory hormones during sepsis. | Levels of glucose, insulin, and glucagon in portal vein plasma and of liver glycogen and cyclic AMP and activities of glycogen synthase and phosphorylase in liver were assayed in control (CONT) rats and rats infected (INF) with Diplococcus pneumoniae. In INF rats compared with CONT rats, insulin and glucagon levels wer... | Altered hepatic glycogen metabolism and glucoregulatory hormones during sepsis. Levels of glucose, insulin, and glucagon in portal vein plasma and of liver glycogen and cyclic AMP and activities of glycogen synthase and phosphorylase in liver were assayed in control (CONT) rats and rats infected (INF) with Diplococcus ... | [
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PMID:5898 | Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys. | Enzymatic histamine synthesis by renal glomeruli of the rat has been examined. Assays of the partially purified enzyme demonstrated a pH optimum of 6.2, a Michaelis-Menten constant of 2.4 X 10(-4) histidine, and lack of potentiation by benzene. These data thus indicate that renal glomeruli contain the histidine-specifi... | Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys. Enzymatic histamine synthesis by renal glomeruli of the rat has been examined. Assays of the partially purified enzyme demonstrated a pH optimum of 6.2, a Michaelis-Menten constant of 2.4 X 10(-4) histidine, and lack of potentiation by ... | [
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PMID:5899 | Effects of temperature transients on gas exchange and acid-base status of turtles. | Pulmonary ventilation (VE), O2 consumption (VO2), and CO2 production (VCO2) were measured continuously on each of 10 turtles, Pseudemys scripta elegans, at 20 degrees C, during and for 1 h after heating to 30 degrees C and during and for 1 h after cooling to 20 degrees C. In seven of the animals, arterial blood was sam... | Effects of temperature transients on gas exchange and acid-base status of turtles. Pulmonary ventilation (VE), O2 consumption (VO2), and CO2 production (VCO2) were measured continuously on each of 10 turtles, Pseudemys scripta elegans, at 20 degrees C, during and for 1 h after heating to 30 degrees C and during and for... | [
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PMID:5900 | Direct effects of various catecholamines on liver circulation in dogs. | As measured by electromagnetic blood flow transducers, direct infusion of epinephrine, norepinephrine, and dopamine into the portal vein (PV) produced a 40-50% decrease in hepatic arterial (HA) blood flow; isoproterenol increased HA flow by about 69%. No changes in PV flow or pressure were observed. Direct HA infusion ... | Direct effects of various catecholamines on liver circulation in dogs. As measured by electromagnetic blood flow transducers, direct infusion of epinephrine, norepinephrine, and dopamine into the portal vein (PV) produced a 40-50% decrease in hepatic arterial (HA) blood flow; isoproterenol increased HA flow by about 69... | [
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PMID:5901 | Clinical response and plasma levels: effect of dose, dosage schedules, and drug interactions on plasma chlorpromazine levels. | Plasma chlorpromazine (CPZ) levels of 50 psychotic inpatients were measured by gas liquid chromatography; the clinical progress of 29 of these patients with acute psychoses was also assessed. CPZ levels of 50-300 ng/ml were usually associated with clinical improvement; there was also a relationship between CPZ levels a... | Clinical response and plasma levels: effect of dose, dosage schedules, and drug interactions on plasma chlorpromazine levels. Plasma chlorpromazine (CPZ) levels of 50 psychotic inpatients were measured by gas liquid chromatography; the clinical progress of 29 of these patients with acute psychoses was also assessed. CP... | [
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PMID:5902 | Accidental hypothermia: core rewarming with partial bypass. | Three patients with profound hypothermia were treated by rewarming on partial bypass. Two surivived and have normal mental and metabolic functions. The resuscitation of the hypothermic patient should be approached with enthusiasm since the outcome is often much better than expected from initial vital signs and neurolog... | Accidental hypothermia: core rewarming with partial bypass. Three patients with profound hypothermia were treated by rewarming on partial bypass. Two surivived and have normal mental and metabolic functions. The resuscitation of the hypothermic patient should be approached with enthusiasm since the outcome is often muc... | [
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PMID:5924 | Premedicant drugs and gastric juice pH and volume in pediatric patients. | The effects of premedication on gastric juice volume and pH were evaluated in five groups of 206 pediatric patients undergoing elective surgical procedures: Group 1 (Control) received no premedication; Group 2 was given morphine sulfate and pentobarbital as premedicants. The other groups received, in addition to morphi... | Premedicant drugs and gastric juice pH and volume in pediatric patients. The effects of premedication on gastric juice volume and pH were evaluated in five groups of 206 pediatric patients undergoing elective surgical procedures: Group 1 (Control) received no premedication; Group 2 was given morphine sulfate and pentob... | [
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PMID:5920 | Arterial hypoxemia caused by intravenous ketamine. | Ketamine given IV in a dose of 2 mg/kg caused a significant reduction in Pao2 in 7 patients spontaneously breathing with an unassisted airway. Under the same conditions, in 7 patients, ketamine (2 mg/kg IV) preceded by diazepam (0.2 mg/kg IV) also caused a reduction in Pao2 not significantly different from that caused ... | Arterial hypoxemia caused by intravenous ketamine. Ketamine given IV in a dose of 2 mg/kg caused a significant reduction in Pao2 in 7 patients spontaneously breathing with an unassisted airway. Under the same conditions, in 7 patients, ketamine (2 mg/kg IV) preceded by diazepam (0.2 mg/kg IV) also caused a reduction in... | [
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PMID:5921 | Clinical investigation of a new intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A). | Twenty-eight patients were anesthetized with etoxadrol as primary agent. The anesthesia produced was characterized by profound analgesia and amnesia, while pharyngeal and laryngeal reflexes, as well as swallowing and lid reflexes, remained active. Systolic, diastolic, and pulse pressure were slightly increased, with as... | Clinical investigation of a new intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A). Twenty-eight patients were anesthetized with etoxadrol as primary agent. The anesthesia produced was characterized by profound analgesia and amnesia, while pharyngeal and laryngeal reflexes, as well as swallowing and li... | [
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PMID:5922 | The effect of enflurane, isoflurane, fluroxene, methoxyflurane and diethyl ether anesthesia on ouabain tolerance in the dog. | Digitalis tolerance in dogs anesthetized with enflurane, isoflurane, fluroxene, methoxyflurane, and diethyl ether was compared with that in dogs anesthetized with pentobarbital. Ouabain dosage needed to cause ventricular tachycardia was significantly higher than that of pentobarbital with all agents except fluroxene, a... | The effect of enflurane, isoflurane, fluroxene, methoxyflurane and diethyl ether anesthesia on ouabain tolerance in the dog. Digitalis tolerance in dogs anesthetized with enflurane, isoflurane, fluroxene, methoxyflurane, and diethyl ether was compared with that in dogs anesthetized with pentobarbital. Ouabain dosage ne... | [
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PMID:5923 | An evaluation of memory under regional anesthesia with IV lorazepam as a premedicant. | Forty male volunteer patients undergoing regional anesthesia were evaluated for alertness and memory in a double-blind study which compared IV lorazepam (4 mg) plus IM meperidine (50 mg) with IV placebo plus IM meperidine (50 mg) as premedicants. The data indicate no significant retrograde effects. Significant differen... | An evaluation of memory under regional anesthesia with IV lorazepam as a premedicant. Forty male volunteer patients undergoing regional anesthesia were evaluated for alertness and memory in a double-blind study which compared IV lorazepam (4 mg) plus IM meperidine (50 mg) with IV placebo plus IM meperidine (50 mg) as p... | [
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PMID:5926 | [2 cases of chylothorax caused by catheterization of left large venous trunks]. | The authors present two cases of almost certain catheterization of the thoracic duct, by infusion catheters placed in the large veins at the base of the neck (once in the left internal jugular, once in the left subclavian). Their clinical manifestaztions are the existence of a rapidly progressive pleural effusion, apar... | [2 cases of chylothorax caused by catheterization of left large venous trunks]. The authors present two cases of almost certain catheterization of the thoracic duct, by infusion catheters placed in the large veins at the base of the neck (once in the left internal jugular, once in the left subclavian). Their clinical m... | [
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PMID:5927 | [Complications of lignocaine]. | In three cases, following cardiac surgery operations, the appearance of a sudden loss of consciousness followed by an epileptic - like crisis was recorded. The accidents have a relationship with an administration of lignocaine in the form of a perfusion. Description of the observations and discussion of the toxicity of... | [Complications of lignocaine]. In three cases, following cardiac surgery operations, the appearance of a sudden loss of consciousness followed by an epileptic - like crisis was recorded. The accidents have a relationship with an administration of lignocaine in the form of a perfusion. Description of the observations an... | [
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PMID:5928 | [Use of a new long acting local anesthetic, etidocaine in anesthesia-resuscitation (Duranest)]. | Our experiment covered 123 patients who were given this new preparation with long action for various types of local and regional anesthesia. In 9 cases of peridural administration for several days, the total doses were very high and tolerance excellent. Results were good for all local and regional anesthesia for which ... | [Use of a new long acting local anesthetic, etidocaine in anesthesia-resuscitation (Duranest)]. Our experiment covered 123 patients who were given this new preparation with long action for various types of local and regional anesthesia. In 9 cases of peridural administration for several days, the total doses were very ... | [
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PMID:5929 | [The MA 1 B respirator. Apropos of an experiment involving 91,300 hours of function]. | Description of the working principle and the characteristics of the Bennet MA 1 B respirator, which is of the release of volume type with electro-mechanical functioning. Study of the advantages and drawbacks. During an experiment involving 91,300 hours of utilization of 21 sets of apparatus, 12 breakdowns concerning a ... | [The MA 1 B respirator. Apropos of an experiment involving 91,300 hours of function]. Description of the working principle and the characteristics of the Bennet MA 1 B respirator, which is of the release of volume type with electro-mechanical functioning. Study of the advantages and drawbacks. During an experiment invo... | [
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PMID:5934 | [Enzyme system and coenzymes involved in the energy metabolism of leukocytes. Function and metabolism of polymorphonuclear neutrophils]. | Mitochondria may be isolated from various types of leukocyte (neutrophil polymorphs and lymphocytes from human blood, neutrophil polymorphs and macrophages from peritoneal exudates of the guinea pig) after destruction by heparin of the cell membrane. This procedure is very simple and less traumatic for these subcellula... | [Enzyme system and coenzymes involved in the energy metabolism of leukocytes. Function and metabolism of polymorphonuclear neutrophils]. Mitochondria may be isolated from various types of leukocyte (neutrophil polymorphs and lymphocytes from human blood, neutrophil polymorphs and macrophages from peritoneal exudates of... | [
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PMID:5930 | [Use of the Cessna 206 for medical evacuations]. | The CESSNA 206 aircraft belonging to the National Police Force has been used to effect medical evacuations. After describing the specifications of this aircraft and underlining its advantages (speed, autonomy, cost price) and its disadvantages (very small cabin, necessity of prepared landing grounds, sound level) compa... | [Use of the Cessna 206 for medical evacuations]. The CESSNA 206 aircraft belonging to the National Police Force has been used to effect medical evacuations. After describing the specifications of this aircraft and underlining its advantages (speed, autonomy, cost price) and its disadvantages (very small cabin, necessit... | [
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PMID:5931 | [Incidence of deep venous thromboses in traumatology and methods of early detection]. | In this work carried out at the Traumatology Centre in Strasbourg, out of 227 patients operated for a fracture situated between the pelvis and the tibial plateau, the authors endeavoured to show a thrombosis of the lower limbs. The means of exploration included in addition to the clinical and biological blood tests an ... | [Incidence of deep venous thromboses in traumatology and methods of early detection]. In this work carried out at the Traumatology Centre in Strasbourg, out of 227 patients operated for a fracture situated between the pelvis and the tibial plateau, the authors endeavoured to show a thrombosis of the lower limbs. The me... | [
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PMID:5935 | Detection of mutant hemoglobins with altered affinity for oxygen. A simplified technique. | The detection of high- or low-affinity hemoglobins in subjects with polycythemia or anemia is difficult for most physicians because of the requirement for special equipment to do oxygen-hemoglobin dissociation curves. Measurement of the pH, oxygen tension, and oxygen saturation of antecubital venous blood with instrume... | Detection of mutant hemoglobins with altered affinity for oxygen. A simplified technique. The detection of high- or low-affinity hemoglobins in subjects with polycythemia or anemia is difficult for most physicians because of the requirement for special equipment to do oxygen-hemoglobin dissociation curves. Measurement ... | [
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PMID:5932 | [Post-traumatic fat embolism of the hemorrhagic pulmonary edema type]. | The authors present a case of post-traumatic fat embolus, which was remarkable by the very haemorrhagic nature of the pulmonary oedema, which healed without sequel. | [Post-traumatic fat embolism of the hemorrhagic pulmonary edema type]. The authors present a case of post-traumatic fat embolus, which was remarkable by the very haemorrhagic nature of the pulmonary oedema, which healed without sequel. | [
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PMID:5936 | Antigenemia in fulminant pneumococcemia. | Two asplenic patients with fulminant pneumococcemia developed purpura and coagulopathy. Levels of C3 and C4 in the serum were low. Both patients had high levels of circulating capsular polysaccharide, and one patient had visible diplococci on a smear of the peripheral blood. Pneumococcal group C polysaccharide (C-subst... | Antigenemia in fulminant pneumococcemia. Two asplenic patients with fulminant pneumococcemia developed purpura and coagulopathy. Levels of C3 and C4 in the serum were low. Both patients had high levels of circulating capsular polysaccharide, and one patient had visible diplococci on a smear of the peripheral blood. Pne... | [
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PMID:5933 | [Acute tamponade: complication of resuscitation (cardiac perforation by a subclavian catheter)]. | The authors report a case of acute tamponnade as result of the collection under pressure of a lipid solution in the pericardium following perforation of the right atrium by a sub-clavian catheter. Diagnosis and treatment were practically siumultaneous. Aspiration of the lipid solution (450 ml) via the catheter confirme... | [Acute tamponade: complication of resuscitation (cardiac perforation by a subclavian catheter)]. The authors report a case of acute tamponnade as result of the collection under pressure of a lipid solution in the pericardium following perforation of the right atrium by a sub-clavian catheter. Diagnosis and treatment we... | [
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PMID:5938 | RNA-protein interactions in alfalfa mosaic virus. | Particles of the bottom component of alfalfa mosaic virus have a compact bacilliform structure at neutral pH. When the pH is raised to 8.3 the structure unfolds. Since the particle weight does not change it is concluded that the protein subunits remain attached to the RNA. The particle weight of the spheroidal top comp... | RNA-protein interactions in alfalfa mosaic virus. Particles of the bottom component of alfalfa mosaic virus have a compact bacilliform structure at neutral pH. When the pH is raised to 8.3 the structure unfolds. Since the particle weight does not change it is concluded that the protein subunits remain attached to the R... | [
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PMID:5939 | Human enolase isozymes: electrophoretic and biochemical evidence for three loci. | 1. Four major enolase isozymes have been identified in human tissues and are referred to as L, M, 'intermediate' and 'fast'. The M isozyme is the major form found in skeletal muscle and heart extracts and the L isozyme the major form found in extracts of liver and most other tissues. The 'intermediate' and 'fast' isozy... | Human enolase isozymes: electrophoretic and biochemical evidence for three loci. 1. Four major enolase isozymes have been identified in human tissues and are referred to as L, M, 'intermediate' and 'fast'. The M isozyme is the major form found in skeletal muscle and heart extracts and the L isozyme the major form found... | [
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PMID:5940 | Adenylate kinases in man: evidence for a third locus. | The tissue distribution of the adenylate kinase isozymes in man has been examined using various substrates. The isozymes attributable to the AK1 and AK2 loci were identified, and an additional set of isozymes probably attributable to a third locus was also found. This locus has been provisionally designated AK3. The AK... | Adenylate kinases in man: evidence for a third locus. The tissue distribution of the adenylate kinase isozymes in man has been examined using various substrates. The isozymes attributable to the AK1 and AK2 loci were identified, and an additional set of isozymes probably attributable to a third locus was also found. Th... | [
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PMID:5942 | [Criteria for evaluating calcium carbonate from the point of view of chlortetracycline biosynthesis]. | Calcium carbonate is added to fermentation media in biosynthesis of tetracyclines for providing definite pH values and binding tetracycline into insoluble complexes. Seven different samples were studied with respect to their physical properties, such as the microscopic size of the particles, their form, capacity for ag... | [Criteria for evaluating calcium carbonate from the point of view of chlortetracycline biosynthesis]. Calcium carbonate is added to fermentation media in biosynthesis of tetracyclines for providing definite pH values and binding tetracycline into insoluble complexes. Seven different samples were studied with respect to... | [
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PMID:5943 | [Study of the penicillin amidase from E. coli. An ultrasonic method of studying the ph- and temperature-conformational transitions in the active center of the enzyme]. | pH and temperature conformation transitions in the active center of penicillin amidase i.e. penicillinamidohydrolase E.C. 3.5.I.II were investigated by means of the kinetic method and a new ultrasonic method. It was shown that the catalytic activity of the enzyme was controlled by 2 ionogenic groups with pK 6.1 and 10.... | [Study of the penicillin amidase from E. coli. An ultrasonic method of studying the ph- and temperature-conformational transitions in the active center of the enzyme]. pH and temperature conformation transitions in the active center of penicillin amidase i.e. penicillinamidohydrolase E.C. 3.5.I.II were investigated by ... | [
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PMID:5945 | [Chromatographic control of the process of rifamycin B isolation and purification]. | A method of chromatography in a thin layer of Silica Cel No. 2 was developed for rifamicin B, rifamicin complex and some admixtures. Extracts of rifamicin B in an organic solvent, aqueous buffer reextracts and dry preparations of rifamicin B were analyzed with the above method. A half-quantitative chromatographic proce... | [Chromatographic control of the process of rifamycin B isolation and purification]. A method of chromatography in a thin layer of Silica Cel No. 2 was developed for rifamicin B, rifamicin complex and some admixtures. Extracts of rifamicin B in an organic solvent, aqueous buffer reextracts and dry preparations of rifami... | [
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PMID:5941 | Regulatory mast cells. I Suppressive action of their products on an in vitro primary immune reaction. | Products of mast cell degranulation, as well as histamine and serotonin, were added to a Mishell and Dutton preparation for in vitro primary immunisation (induction of IgM antibody formation) to sheep or horse red blood cells. Degranulation products were either obatined beforehand by reacting passively sensitised mast ... | Regulatory mast cells. I Suppressive action of their products on an in vitro primary immune reaction. Products of mast cell degranulation, as well as histamine and serotonin, were added to a Mishell and Dutton preparation for in vitro primary immunisation (induction of IgM antibody formation) to sheep or horse red bloo... | [
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PMID:5946 | [Relationship between the antibacterial activity and the acceptor properties of certain penicillins]. | Antibacterial activity of 2 natural and 12 semisynthetic penicillins against 5 strains of grampositive bacteria was determined and quantum chemical estimation of their molecules was performed with the Hukkel method. The data were indicative of the fact that antibacterial activity of the penicillins was connected with t... | [Relationship between the antibacterial activity and the acceptor properties of certain penicillins]. Antibacterial activity of 2 natural and 12 semisynthetic penicillins against 5 strains of grampositive bacteria was determined and quantum chemical estimation of their molecules was performed with the Hukkel method. Th... | [
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PMID:5947 | [Effect of different factors on the rate of benzylpenicillin conversion in an aqueous system-butylacetate system]. | It was shown that the mass-transfer coefficient of non-dissociated benzylpenicillin during extraction was more than 1000 times higher than that during reextraction. For the latter it was found that the aqueous phase exerted limiting resistance during mass-transfer of benzylpenicillin. The effect of a number of factors ... | [Effect of different factors on the rate of benzylpenicillin conversion in an aqueous system-butylacetate system]. It was shown that the mass-transfer coefficient of non-dissociated benzylpenicillin during extraction was more than 1000 times higher than that during reextraction. For the latter it was found that the aqu... | [
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PMID:5948 | [Regulation of tetracycline biosynthesis by controlling the growth of the producer]. | Regulation of the rate growth of Act. aureofaciens in batch fermentation by maintaining the concentrations of phosphorus, ammonium nitrogen, glucose and pH values at the levels favourable for intensive growth at the beginning of the process and after accumulation of the biomass at the levels optimal for retarded growth... | [Regulation of tetracycline biosynthesis by controlling the growth of the producer]. Regulation of the rate growth of Act. aureofaciens in batch fermentation by maintaining the concentrations of phosphorus, ammonium nitrogen, glucose and pH values at the levels favourable for intensive growth at the beginning of the pr... | [
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PMID:5949 | [Study of the biosynthesis of a carbohydrate fragment of rubomycin]. | When the rubomycin-producing organism was grown in the presence of an evenly labeled C14-glucose and various non-labeled carbon sources, the carbohydrate part of the antibiotic also became evently labeled. The activity of I carbon atom of rubomycin sugar grown against the background of non-labeled glycerol was almost 3... | [Study of the biosynthesis of a carbohydrate fragment of rubomycin]. When the rubomycin-producing organism was grown in the presence of an evenly labeled C14-glucose and various non-labeled carbon sources, the carbohydrate part of the antibiotic also became evently labeled. The activity of I carbon atom of rubomycin su... | [
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PMID:5950 | [Physicochemical properties of 7-phenylacetamidodesacetoxy-cephalosporanic acid]. | 7-phenylacetamidodesacetoxycephalosporanic acid was prepared by transformation of benzylpenicillin. The acid was subjected to potentiometric titration and investigation of its electrophoretic mobility at wide pH ranges. The data of the potentiometric titration and electrophoresis were used for calculation of the acid i... | [Physicochemical properties of 7-phenylacetamidodesacetoxy-cephalosporanic acid]. 7-phenylacetamidodesacetoxycephalosporanic acid was prepared by transformation of benzylpenicillin. The acid was subjected to potentiometric titration and investigation of its electrophoretic mobility at wide pH ranges. The data of the po... | [
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PMID:5951 | Beta-glucosidase of Trichoderma: its biosynthesis and role in saccharification of cellulose. | The extracellular beta-glucosidase of Trichoderma viride generally is present in low levels when the organism is cultured on cellulose because it is inactivated under the acid conditions which develop in the medium while the other enzymes of the cellulase complex are more stable. With the appropriate pH control, inacti... | Beta-glucosidase of Trichoderma: its biosynthesis and role in saccharification of cellulose. The extracellular beta-glucosidase of Trichoderma viride generally is present in low levels when the organism is cultured on cellulose because it is inactivated under the acid conditions which develop in the medium while the ot... | [
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PMID:5952 | Growth of Fusarium moniliforme on carob aqueous extract and nutritional evaluation of its biomass. | Fusarium moniliforme was cultured semicontinuously on a carob medium in a 14-liter fermentor (8.5-liter working volume). The growth medium provided 2.4% carob sugar, 0.72% NH4H2PO4, and 0.03% MgSO4-7H2O. The biomass harvest was 8.8 g/liter per day. Ninety percent of the sugars were consumed, and the pH dropped from 5.9... | Growth of Fusarium moniliforme on carob aqueous extract and nutritional evaluation of its biomass. Fusarium moniliforme was cultured semicontinuously on a carob medium in a 14-liter fermentor (8.5-liter working volume). The growth medium provided 2.4% carob sugar, 0.72% NH4H2PO4, and 0.03% MgSO4-7H2O. The biomass harve... | [
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PMID:5953 | Incorporation of proline into prodigiosin by a Put mutant of Serratia marcesens. | A Put mutant of Serratia marcescens, deficient in proline oxidase and therefore unable to degrade proline, was used to assay for an enzymatic reaction responsible for incorporation of proline into prodigiosin. The reaction had a pH optimum of 7.5 and a Km of 1.1 X 10(-4) M at 27 C. At temperatures above 27 C, the veloc... | Incorporation of proline into prodigiosin by a Put mutant of Serratia marcesens. A Put mutant of Serratia marcescens, deficient in proline oxidase and therefore unable to degrade proline, was used to assay for an enzymatic reaction responsible for incorporation of proline into prodigiosin. The reaction had a pH optimum... | [
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PMID:5954 | Enzymatic conversion of sterigmatocystin into aflatoxin B1 by cell-free extracts of Aspergillus parasiticus. | A cell-free extract, prepared from Aspergillus parasiticus ATCC 15517 grown in synthetic medium, was active in converting [14C]sterigmatocystin into aflatoxin B1 in the presence of reduced nicotinamide adenine dinucleotide phosphate. The activity was demonstrated by the time course of conversion and the linear dependen... | Enzymatic conversion of sterigmatocystin into aflatoxin B1 by cell-free extracts of Aspergillus parasiticus. A cell-free extract, prepared from Aspergillus parasiticus ATCC 15517 grown in synthetic medium, was active in converting [14C]sterigmatocystin into aflatoxin B1 in the presence of reduced nicotinamide adenine d... | [
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PMID:5963 | Cord gamma glutamyl transpeptidase activity and neonatal jaundice. | gamma Glutamyl transpeptidase (GGT) activity was measured in normal neonates and in maternal serum post partum. Levels were above the normal adult range (35I U/1) in all neonates and a significant correlation was bound between enzyme activity and bilirubin levels on day 7(P less than 0-005). The mean bilirubin level on... | Cord gamma glutamyl transpeptidase activity and neonatal jaundice. gamma Glutamyl transpeptidase (GGT) activity was measured in normal neonates and in maternal serum post partum. Levels were above the normal adult range (35I U/1) in all neonates and a significant correlation was bound between enzyme activity and biliru... | [
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PMID:5964 | Cardiorespiratory response to feeding in newborn infants. | Milk feeds were given through indwelling nasogastric tubes to 14 infants with respiratory distress. Similar cardiorespiratory disturbances were observed when the infants were fed (5 ml/kg per feed) human milk, cow's mild, or distilled water. Pao2 fell after a feed but recovered to the prefeed value at 30 minutes, at w... | Cardiorespiratory response to feeding in newborn infants. Milk feeds were given through indwelling nasogastric tubes to 14 infants with respiratory distress. Similar cardiorespiratory disturbances were observed when the infants were fed (5 ml/kg per feed) human milk, cow's mild, or distilled water. Pao2 fell after a fe... | [
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PMID:5971 | Clinical experience with the Teflo disposable membrane oxygenator. | A simple, inexpensive, highly efficient disposable membrane oxygenator with low priming volume and a microporous membrane recently has become available. Animal and clinical investigations of its use have been most satisfactory, and clinical experience now has been extended to include 285 patients. Its primary advantage... | Clinical experience with the Teflo disposable membrane oxygenator. A simple, inexpensive, highly efficient disposable membrane oxygenator with low priming volume and a microporous membrane recently has become available. Animal and clinical investigations of its use have been most satisfactory, and clinical experience n... | [
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PMID:5972 | Hypothermia and rewarming by peritoneal dialysis and temperature-controlled inhalate. | In 12 rabbits hypothermia and rewarming were induced with temperature-controlled circulating peritoneal dialysis in combination with temperature-controlled hypoxic and hypercapnic gas mixtures. The average cooling time necessary for the esophageal temperature to decrease from 37.7 degrees +/- 0.7 to 20.6 degrees +/- 1.... | Hypothermia and rewarming by peritoneal dialysis and temperature-controlled inhalate. In 12 rabbits hypothermia and rewarming were induced with temperature-controlled circulating peritoneal dialysis in combination with temperature-controlled hypoxic and hypercapnic gas mixtures. The average cooling time necessary for t... | [
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PMID:5973 | Angioplastic repair of a ruptured pulmonary artery aneurysm. | A 28-year-old woman had a ruptured solitary pulmonary arterial aneurysm which was successfully treated by pericardial patch graft. The etiology of the aneurysm could not be determined although the patient had had several episodes of blunt chest trauma in the past. Unusual aspects of this case include: location of the a... | Angioplastic repair of a ruptured pulmonary artery aneurysm. A 28-year-old woman had a ruptured solitary pulmonary arterial aneurysm which was successfully treated by pericardial patch graft. The etiology of the aneurysm could not be determined although the patient had had several episodes of blunt chest trauma in the ... | [
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PMID:5974 | Suppression of renin release by timolol. | The beta-adrenergic blocking agent, timolol, administered to resting rabbits as an i.v. bolus (0.125 mg/kg) sustained by a 2-hr infusion at 0.0625 mg/kg/hr, caused significant depression of plasma renin activity (PRA) to 49% of the control level. Significant correlations emerged between the fall in mean blood pressure ... | Suppression of renin release by timolol. The beta-adrenergic blocking agent, timolol, administered to resting rabbits as an i.v. bolus (0.125 mg/kg) sustained by a 2-hr infusion at 0.0625 mg/kg/hr, caused significant depression of plasma renin activity (PRA) to 49% of the control level. Significant correlations emerged... | [
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PMID:5975 | Effect of sodium acetate infusion on renal function in the dog. | Sodium acetate (AC) is routinely used in dialysis solutions in hemodialysis units as it provides a ready source of fixed base. The renal dynamics of the buffer salt are not well known. Anesthetized dogs received i.v. infusions of AC at a rate of 40 to 600 muEq/kg/min. Urinary AC and bicarbonate excretion was measured a... | Effect of sodium acetate infusion on renal function in the dog. Sodium acetate (AC) is routinely used in dialysis solutions in hemodialysis units as it provides a ready source of fixed base. The renal dynamics of the buffer salt are not well known. Anesthetized dogs received i.v. infusions of AC at a rate of 40 to 600 ... | [
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PMID:5976 | Effects of intravenous anesthetics on continuous avoidance behavior in the rat. | The actions of ketamine, etoxadrol and thiopental on continuous avoidance behavior in the rat were evaluated following i.v. administration. Ketamine and thiopental exerted only a depressant effect on avoidance behavior which was attributable to the anesthetic properties of the drugs. In contrast, biphasic activity was ... | Effects of intravenous anesthetics on continuous avoidance behavior in the rat. The actions of ketamine, etoxadrol and thiopental on continuous avoidance behavior in the rat were evaluated following i.v. administration. Ketamine and thiopental exerted only a depressant effect on avoidance behavior which was attributabl... | [
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PMID:5977 | Drugs and PGO waves in the lateral geniculate body of the curarized cat. V. Miscellaneous compounds. Synopsis of the role of central neurotransmitters on PGO wave activity. | In the last part of this series we have studied the effects of various drugs on ponto-geniculo-occipital (PGO) waves induced by the benzoquinolizine derivative, Ro 4-1284 (PGO(1284)), and by the inhibitor of trypotophan hydroxylase, p-chlorophenylalanine (PGO(PCPA)), and continuously recorder and counted in the lateral... | Drugs and PGO waves in the lateral geniculate body of the curarized cat. V. Miscellaneous compounds. Synopsis of the role of central neurotransmitters on PGO wave activity. In the last part of this series we have studied the effects of various drugs on ponto-geniculo-occipital (PGO) waves induced by the benzoquinolizin... | [
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0... |
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