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PMID:5612 | Biotransformation, sex hormones, and toxicity of two volatile anesthetics in mice. | Male and female DBA 11 mice recovered from 1 hr of anesthesia with chloroform of fluoroxene apparently unharmed. However, many of the animals died within 24-48 hr after anesthesia. Pretreatment with phenobarbital increased, while pretreatment with a small dose of carbon tetrachloride decreased, this toxicity. Relativel... | Biotransformation, sex hormones, and toxicity of two volatile anesthetics in mice. Male and female DBA 11 mice recovered from 1 hr of anesthesia with chloroform of fluoroxene apparently unharmed. However, many of the animals died within 24-48 hr after anesthesia. Pretreatment with phenobarbital increased, while pretrea... | [
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PMID:5613 | Neuronal control of neurotransmitters biosynthesis during development. | Studies on neuronal control mechanisms of neurotransmitters biosynthesis during the development of peripheral and central autonomic synapses are reviewed. Particular emphasis is placed on investigations of developing peripheral sympathetic ganglia and brain in chick embryo and chick. Studies on the development of auton... | Neuronal control of neurotransmitters biosynthesis during development. Studies on neuronal control mechanisms of neurotransmitters biosynthesis during the development of peripheral and central autonomic synapses are reviewed. Particular emphasis is placed on investigations of developing peripheral sympathetic ganglia a... | [
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PMID:5614 | Isolation and properties of the replicase of encephalomyocarditis virus. | The RNA-dependent RNA polymerase (replicase) of encephalomyocarditis (EMC) virus was found to be closely associated with the smooth membranes of infected BHK-21 cells. An RNA-dependent EMC replicase was extracted from the membranes with 0.15% sodium dodecyl sulfate (SDS) and 1,1,2-trichlorotri-fluoroethane (Genetron 11... | Isolation and properties of the replicase of encephalomyocarditis virus. The RNA-dependent RNA polymerase (replicase) of encephalomyocarditis (EMC) virus was found to be closely associated with the smooth membranes of infected BHK-21 cells. An RNA-dependent EMC replicase was extracted from the membranes with 0.15% sodi... | [
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PMID:5615 | Comparative properties of bacteriophage phi6 and phi6 nucleocapsid. | Nonionic detergent treatments released a nucleocapsid from the enveloped bacteriphage phi6. The nucleocapsid sedimented at nearly the same rate as the whole phage in sucrose density gradients, but the buoyant density in Cs2S04 changed from 1.22 g/cm3 for the whole phage to 1.33 g/cm3 for the nucleocapsid. The detergent... | Comparative properties of bacteriophage phi6 and phi6 nucleocapsid. Nonionic detergent treatments released a nucleocapsid from the enveloped bacteriphage phi6. The nucleocapsid sedimented at nearly the same rate as the whole phage in sucrose density gradients, but the buoyant density in Cs2S04 changed from 1.22 g/cm3 f... | [
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PMID:5616 | Urologic manifestations of polyarteritis nodosa. | Polyarteritis nodosa is an unusual condition that infrequently presents with signs and symptoms essentially confined to the urinary system. Such a case necessitating bilateral nephrectomy owing to hemorrhage is described. The pathologic findings, pathophysiology and etiology of the condition as well as treatment by ren... | Urologic manifestations of polyarteritis nodosa. Polyarteritis nodosa is an unusual condition that infrequently presents with signs and symptoms essentially confined to the urinary system. Such a case necessitating bilateral nephrectomy owing to hemorrhage is described. The pathologic findings, pathophysiology and etio... | [
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PMID:5617 | [Effects of pH on the processes of excitation-contraction coupling of bullfrog atrium (author's transl)]. | It has long been demonstrated that in cardiac muscle alterations in the extracellular pH exhibit a remarkable inotropic effect, whereas the precise mechanism is not fully clarified yet in spite of many associated thories. In recent years, however, abundant informations about the processes of excitation-contraction coup... | [Effects of pH on the processes of excitation-contraction coupling of bullfrog atrium (author's transl)]. It has long been demonstrated that in cardiac muscle alterations in the extracellular pH exhibit a remarkable inotropic effect, whereas the precise mechanism is not fully clarified yet in spite of many associated t... | [
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PMID:5619 | [Gentamicin-susceptibility of various pathogens isolated from clinical materials]. | We studied on the antibacterial activity of gentamicin against various pathogens isolated from clinical materials mainly isolated during 1974 and 1975, comparing with other antibiotics. Beta hemolytic streptococci, pneumococci and enterococci are less susceptible to gentamicin than staphylococci. Staph, aureus and Stap... | [Gentamicin-susceptibility of various pathogens isolated from clinical materials]. We studied on the antibacterial activity of gentamicin against various pathogens isolated from clinical materials mainly isolated during 1974 and 1975, comparing with other antibiotics. Beta hemolytic streptococci, pneumococci and entero... | [
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PMID:5621 | Effects of changing levels of glucocorticosteroids on heat exposure in rabbit. | Rabbits exposed for one hour to a temperature of 40degrees Cand 35-37% humidity showed elevated plasma osmolality and pH. Most of the animals were not able to withstand the heat. Dexamethasone-treated rabbits under the same conditions withstood the heat better and their plasma pH and osmolality remained constant. Metop... | Effects of changing levels of glucocorticosteroids on heat exposure in rabbit. Rabbits exposed for one hour to a temperature of 40degrees Cand 35-37% humidity showed elevated plasma osmolality and pH. Most of the animals were not able to withstand the heat. Dexamethasone-treated rabbits under the same conditions withst... | [
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PMID:5622 | Changes in contractility and calcium binding of guinea pig taenia coli by treatment with enzymes which hydrolyze sialic acid. | The effects of neuraminidase and phospholipase C on the contractility and the Ca++ -binding of guinea pig taenia coli were investigated. Potassium contracture or histamine-induced contracture of taenia coli was inhibited by treatment with neuraminidase, though acetylcholine-induced contracture was not. Treatment with p... | Changes in contractility and calcium binding of guinea pig taenia coli by treatment with enzymes which hydrolyze sialic acid. The effects of neuraminidase and phospholipase C on the contractility and the Ca++ -binding of guinea pig taenia coli were investigated. Potassium contracture or histamine-induced contracture of... | [
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PMID:5623 | [Treatment of acute respiratory insufficiency in cardiac surgery]. | An analysis of the main causes of acute respiratory insufficiency as a frequently observed and severe complication of the early postoperative period after open-heart surgery is presented. To permit differentiated employment of respiratory resuscitation measures, subcompensated and decompensated forms of acute postopera... | [Treatment of acute respiratory insufficiency in cardiac surgery]. An analysis of the main causes of acute respiratory insufficiency as a frequently observed and severe complication of the early postoperative period after open-heart surgery is presented. To permit differentiated employment of respiratory resuscitation ... | [
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PMID:5625 | [Isoenzyme differentiation of gamma-glutamyltransferase by concanavalin A and Con- A-Sepharose (author's transl)]. | In this investigation a new possibility of isoenzyme-differentiation of the gamma-glutamyl-transferase (GGT) (EC Nr.2.3.2.2.) was demonstrated by Concanavalin A and Con A-Sepharose. Because of the different sugar content of the glycoproteins distinction between liver- and kidney-GGT is possible. Furthermore it was poss... | [Isoenzyme differentiation of gamma-glutamyltransferase by concanavalin A and Con- A-Sepharose (author's transl)]. In this investigation a new possibility of isoenzyme-differentiation of the gamma-glutamyl-transferase (GGT) (EC Nr.2.3.2.2.) was demonstrated by Concanavalin A and Con A-Sepharose. Because of the differen... | [
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PMID:5626 | Investigations on the function of the rat forestomach. | The functions of the rat forestomach and upper digestive tract were studied. The pH values, alpha-amylase activity, quantitative estimates of microorganisms, and emptying rates were higher in the forestomach than in the glandular stomach. Rats with surgically removed forestomachs lived without complications for more th... | Investigations on the function of the rat forestomach. The functions of the rat forestomach and upper digestive tract were studied. The pH values, alpha-amylase activity, quantitative estimates of microorganisms, and emptying rates were higher in the forestomach than in the glandular stomach. Rats with surgically remov... | [
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PMID:5627 | Removal of basement membrane in the involuting breast. | Morphologic and immunohistochemical studies by light and electron microscopy indicated that basement membrane was removed during the process of involution of the murine breast. Removal of the basement membrane started 2 days postweaning, was maximal at 4 days, and correlated with degeneration of epithelial cells. There... | Removal of basement membrane in the involuting breast. Morphologic and immunohistochemical studies by light and electron microscopy indicated that basement membrane was removed during the process of involution of the murine breast. Removal of the basement membrane started 2 days postweaning, was maximal at 4 days, and ... | [
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PMID:5634 | The effects of dopamine and isoproterenol on the pulmonary circulation. | Dopamine and isoproterenol, although used primarily for their inotropic effects, are also potent vasoactive substances. To determine their effects on the pulmonary circulation, we cannulated the left lower lobe bronchus in 20 dogs to permit ventilation with either air or a mixture of 95% nitrogen and 5% carbon dioxide;... | The effects of dopamine and isoproterenol on the pulmonary circulation. Dopamine and isoproterenol, although used primarily for their inotropic effects, are also potent vasoactive substances. To determine their effects on the pulmonary circulation, we cannulated the left lower lobe bronchus in 20 dogs to permit ventila... | [
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PMID:5635 | Biochemistry of copper. | Copper, as a component of numerous cuproenzymes, plays a vital role in many physiologic functions in man and animals. From the stand-point of human health there are at least three functional areas of prime importance. Copper is involved in the development and maintenance of cardiovascular and skeletal integrity, centra... | Biochemistry of copper. Copper, as a component of numerous cuproenzymes, plays a vital role in many physiologic functions in man and animals. From the stand-point of human health there are at least three functional areas of prime importance. Copper is involved in the development and maintenance of cardiovascular and sk... | [
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PMID:5644 | Effects of dietary saturated and trans fatty acids on cholesteryl ester synthesis and hydrolysis in the testes of rats. | Studies were made of the enzymic synthesis and hydrolysis of cholesteryl esters in rat testes. Weanling rats were fed for 14 weeks diets containing 5% by wt of hydrogenated coconut oil (HCO), a concentrate of ethyl elaidate and linolelaidate (TRANS), devoid of essential fatty acids (EFA), or safflower oil (SAFF). Chole... | Effects of dietary saturated and trans fatty acids on cholesteryl ester synthesis and hydrolysis in the testes of rats. Studies were made of the enzymic synthesis and hydrolysis of cholesteryl esters in rat testes. Weanling rats were fed for 14 weeks diets containing 5% by wt of hydrogenated coconut oil (HCO), a concen... | [
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PMID:5648 | Defective lipid disposal mechanisms during bacterial infection in rhesus monkeys. | Mechanisms producing hypertriglyceridemia during bacterial sepsis have not been well defined. In this study lipid disposal mechanisms were assessed in 76 infected and 19 control male rhesus monkeys by the ability to dispose of triglycerides after: (1) oral lipid loading; (2) intravenous lipid loading; and (3) by lipoly... | Defective lipid disposal mechanisms during bacterial infection in rhesus monkeys. Mechanisms producing hypertriglyceridemia during bacterial sepsis have not been well defined. In this study lipid disposal mechanisms were assessed in 76 infected and 19 control male rhesus monkeys by the ability to dispose of triglycerid... | [
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PMID:5643 | Sweetening agents from natural sources. | Sweetness is an important taste sensation to humans. The absence of suitable sweeteners as alternatives to cyclamates and saccharin has led to a renewed interest in sweeteners form natural sources. A brief review of the history of sweetener usage provides a basis for understanding our present heavy consumption of sweet... | Sweetening agents from natural sources. Sweetness is an important taste sensation to humans. The absence of suitable sweeteners as alternatives to cyclamates and saccharin has led to a renewed interest in sweeteners form natural sources. A brief review of the history of sweetener usage provides a basis for understandin... | [
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PMID:5650 | [Mendelson's syndrome (author's transl)]. | It is reported on 10 patients with the features of Mendelson's syndrome; 4 patients died. Diagnosis, therapy, course and prognosis of this severe complication following aspiration of gastric hydrochloric acid are discussed. | [Mendelson's syndrome (author's transl)]. It is reported on 10 patients with the features of Mendelson's syndrome; 4 patients died. Diagnosis, therapy, course and prognosis of this severe complication following aspiration of gastric hydrochloric acid are discussed. | [
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PMID:5649 | The effects of nalorphine and naloxone on maternal and fetal blood gas and pH. | In the control trials on near-term pregnant women before the onset of labour, nalorphine was found to cause a mild respiratory acidosis in the mother and metabolic acidosis in the fetus. These effects were not apparent when naloxone was administered. | The effects of nalorphine and naloxone on maternal and fetal blood gas and pH. In the control trials on near-term pregnant women before the onset of labour, nalorphine was found to cause a mild respiratory acidosis in the mother and metabolic acidosis in the fetus. These effects were not apparent when naloxone was admi... | [
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PMID:5651 | [Investigations of the lipase activity of a pancreatin compound (author's transl)]. | In connection with the physiologic process of digestion, the requirements for an enzyme-based drug are stated. Quick release of highly active enzymes in the duodenum is a prerequisite of physiological stimulation of the pancreatic excretory function. Digestive potency is regarded as a suitable gauge for comparing of re... | [Investigations of the lipase activity of a pancreatin compound (author's transl)]. In connection with the physiologic process of digestion, the requirements for an enzyme-based drug are stated. Quick release of highly active enzymes in the duodenum is a prerequisite of physiological stimulation of the pancreatic excre... | [
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PMID:5665 | Characterisation of eukaryotic ribosomal proteins. | A simple method of two-dimensional polyacrylamide gel electrophoresis is described which affords: (1) high resolution of eukaryotic ribosomal proteins; (2) good recovery of protein in the transfer from first to second dimension; and (3) characterisation of the separated proteins in terms of molecular weights and other ... | Characterisation of eukaryotic ribosomal proteins. A simple method of two-dimensional polyacrylamide gel electrophoresis is described which affords: (1) high resolution of eukaryotic ribosomal proteins; (2) good recovery of protein in the transfer from first to second dimension; and (3) characterisation of the separate... | [
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PMID:5666 | Study on proteins from yeast cytoplasmic ribosomes by two-dimensional gel electrophoresis. | Proteins of yeast cytoplasmic ribosomes were analyzed by two different methods of two dimensional gel electrophoresis: run at pH 8.6 in 1-D1 and at pH 4.6 in 2-D (Method A); run at pH 5.0 in 1-D and in the presence of sodium dodecyl sulfate in 2-D (Method B). The numbers of proteins estimated were 28 (Method A) and 29 ... | Study on proteins from yeast cytoplasmic ribosomes by two-dimensional gel electrophoresis. Proteins of yeast cytoplasmic ribosomes were analyzed by two different methods of two dimensional gel electrophoresis: run at pH 8.6 in 1-D1 and at pH 4.6 in 2-D (Method A); run at pH 5.0 in 1-D and in the presence of sodium dode... | [
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PMID:5667 | Conformational changes in cytochrome aa3 and ATP synthetase of the mitochondrial membrane and their role in mitochondrial energy transduction. | 1. The thermodynamics and molecular basis of energy-linked conformational changes in the cytochrome aa3 and ATP synthetase complexes of the mitochondrial membrane have been studied with spectrophotometrical and fluorometrical techniques. 2. Ferric cytochrome aa3 exists in two conformations, high spin and low spin, the ... | Conformational changes in cytochrome aa3 and ATP synthetase of the mitochondrial membrane and their role in mitochondrial energy transduction. 1. The thermodynamics and molecular basis of energy-linked conformational changes in the cytochrome aa3 and ATP synthetase complexes of the mitochondrial membrane have been stud... | [
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PMID:5668 | [Old and new dangers of blood transfusion (author's transl)]. | The predominant danger of blood transfusion, even after the discovery of the ABO and Rh systems, is the immunological risk. This led in 1940 to a regulation of blood transfusion in Germany by official guidelines which were constantly adjusted in the light of new research results. The dangers due to deterioration on sto... | [Old and new dangers of blood transfusion (author's transl)]. The predominant danger of blood transfusion, even after the discovery of the ABO and Rh systems, is the immunological risk. This led in 1940 to a regulation of blood transfusion in Germany by official guidelines which were constantly adjusted in the light of... | [
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PMID:5669 | Vinyl chloride dependent mutagensis: effects of liver extracts and free radicals. | The mutagenic effects of vinyl chloride (VC) on Salmonella typhimurium strain TA1530 are enhanced by mouse or rat liver extracts. The extracts prepared from mice pretreated either with vinyl chloride or the microsomal enzyme inducer, Aroclor 1254, did not produce any greater stimulation of VC-dependent mutagenesis than... | Vinyl chloride dependent mutagensis: effects of liver extracts and free radicals. The mutagenic effects of vinyl chloride (VC) on Salmonella typhimurium strain TA1530 are enhanced by mouse or rat liver extracts. The extracts prepared from mice pretreated either with vinyl chloride or the microsomal enzyme inducer, Aroc... | [
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PMID:5671 | Testicular function after orchiopexy for unilaterally undescended testis. | Testicular function was determined in 29 men, 21 to 35 years old, who had undergone orchiopexy for unilaterally undescended testis at four to 12 years of age. Serum testosterone and dialyzable testosterone concentrations of these men were not significantly different from those of a control group of 30 normal men, and t... | Testicular function after orchiopexy for unilaterally undescended testis. Testicular function was determined in 29 men, 21 to 35 years old, who had undergone orchiopexy for unilaterally undescended testis at four to 12 years of age. Serum testosterone and dialyzable testosterone concentrations of these men were not sig... | [
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PMID:5674 | [Isolation and characterization of main albumin fractions of seeds from sunflower (Helianthus annuus L.) and rape (Brassica napus L.)]. | The main fractions of the albumins from sunflower and rapeseeds (isolated by means of precipitation with ammonium sulphate or tannin + caffeine and subsequent gel chromatography) are low-molecular, very basic proteins. Their molecular weights range from 10 000 to 16 000, and their isoelectric points (determined by isoe... | [Isolation and characterization of main albumin fractions of seeds from sunflower (Helianthus annuus L.) and rape (Brassica napus L.)]. The main fractions of the albumins from sunflower and rapeseeds (isolated by means of precipitation with ammonium sulphate or tannin + caffeine and subsequent gel chromatography) are l... | [
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PMID:5676 | [Effect of acid polysaccharides on properties of pancreatic proteases]. | The use of acid polysaccharides (sodium alginate, pectin, carrageenan, etc.) as gel-forming agents in the manufacture of artificial foods excites the interest in the study of their effects on the enzymes of the gastrointestinal tract. In this connection, the authors investigated the action of various acid polysaccharid... | [Effect of acid polysaccharides on properties of pancreatic proteases]. The use of acid polysaccharides (sodium alginate, pectin, carrageenan, etc.) as gel-forming agents in the manufacture of artificial foods excites the interest in the study of their effects on the enzymes of the gastrointestinal tract. In this conne... | [
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PMID:5677 | [Interaction between proteins and acid polysaccharides]. | The intereaction between proteins and acid polysaccharides is electrostatic in nature and leads to the formation of soluble charged and insoluble neutral complexes. The complex formation in the system casein-dextran sulphate is followed by means of turbidimetric titration. It depends on the pH value and the electrolyte... | [Interaction between proteins and acid polysaccharides]. The intereaction between proteins and acid polysaccharides is electrostatic in nature and leads to the formation of soluble charged and insoluble neutral complexes. The complex formation in the system casein-dextran sulphate is followed by means of turbidimetric ... | [
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PMID:5678 | [Isolation of proteins with complex forming agents]. | Taking vegetable albumins for models, the authors report of the possibilities of isolating proteins (which cannot be precipitated isoelectrically) by using their property of forming complexes with tannin or poly-anions. The precipitation of proteins with dextran sulphate or polyphosphates, which is due to electrostatic... | [Isolation of proteins with complex forming agents]. Taking vegetable albumins for models, the authors report of the possibilities of isolating proteins (which cannot be precipitated isoelectrically) by using their property of forming complexes with tannin or poly-anions. The precipitation of proteins with dextran sulp... | [
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PMID:5679 | [Technological directions for processing rape proteins into protein concentrates and isolates]. | Rape-seeds or rape-seed meal are relatively cheap, but valuable raw materials for the manufacture of protein concentrates and isolates which may be used as constituents of foodstuffs. The high content of crude fibres and also of thioglucosides leads to considerable difficulties in the development of techniques for the ... | [Technological directions for processing rape proteins into protein concentrates and isolates]. Rape-seeds or rape-seed meal are relatively cheap, but valuable raw materials for the manufacture of protein concentrates and isolates which may be used as constituents of foodstuffs. The high content of crude fibres and als... | [
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PMID:5680 | [Mass transfer in production of milk protein coprecipitates]. | During the last twenty years heat coagulation has become a more important technical procedure for the isolation of milk proteins because of its very efficient utilization of raw material. Experiments are reported to get approximation equations for the mass transfer in the production of milk protein coprecipitates from ... | [Mass transfer in production of milk protein coprecipitates]. During the last twenty years heat coagulation has become a more important technical procedure for the isolation of milk proteins because of its very efficient utilization of raw material. Experiments are reported to get approximation equations for the mass t... | [
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PMID:5686 | [The effect of novocaine on the electrical activity of nodes of Ranvier in high and low pH solutions]. | The minimal concentrations of procaine which block the action potentials of a single Ranvier node were determined under decreased and increased pH in the bathing solution. The changes in concentrations of the basic [B] and cationic [BH+] form of procaine with pH were of monotonic character: [B] drops and [BH+] grows wi... | [The effect of novocaine on the electrical activity of nodes of Ranvier in high and low pH solutions]. The minimal concentrations of procaine which block the action potentials of a single Ranvier node were determined under decreased and increased pH in the bathing solution. The changes in concentrations of the basic [... | [
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PMID:5687 | [The effect of the pH of the external solution on posttetanic hyperpolarization of a denuded nerve]. | A decrease in pH of the external solution from 7.3 to 5.3 causes an increase in post-tetanic hyperpolarization, while an increase in pH to 9 causes its decrease. The time-course of the hyperpolarization was increased at low pH and reduced at high pH. The possibility of a change in the electrogenicity of the sodium pum... | [The effect of the pH of the external solution on posttetanic hyperpolarization of a denuded nerve]. A decrease in pH of the external solution from 7.3 to 5.3 causes an increase in post-tetanic hyperpolarization, while an increase in pH to 9 causes its decrease. The time-course of the hyperpolarization was increased at... | [
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PMID:5688 | Kinetics of thymus-derived lymphocyte count changes in rats affected by graft-versus-host reaction. | The effect of GVHR on thymus-dependent lymphocytes of various lymphoid organs has been followed autoradiographically and by scintillation technique in a temporal dependence on the induction of the reaction. GVHR was induced in (BD X Lw) F1 hybrid rats with parental spleen (BD) cells. As marker of the thymus-dependent l... | Kinetics of thymus-derived lymphocyte count changes in rats affected by graft-versus-host reaction. The effect of GVHR on thymus-dependent lymphocytes of various lymphoid organs has been followed autoradiographically and by scintillation technique in a temporal dependence on the induction of the reaction. GVHR was indu... | [
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PMID:5692 | Effect of chlorogenic acid in a casein diet for rats. Nutritional and pathological observations. | 3-week-old male rats were fed on a casein diet containing 1% (w/w) of chlorogenic acid in order to find out if the ingestion of chlorogenic acid may be associated with a reduced utilization of dietary proteins or with causing other adverse effects. The protein efficiency ratio, biological value and digestibility of thi... | Effect of chlorogenic acid in a casein diet for rats. Nutritional and pathological observations. 3-week-old male rats were fed on a casein diet containing 1% (w/w) of chlorogenic acid in order to find out if the ingestion of chlorogenic acid may be associated with a reduced utilization of dietary proteins or with causi... | [
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PMID:5693 | Influence of experimental dietary conditions on hepatic enzymes of glutamic acid metabolism in rats. | The lowering levels of dietary protein induced a significant fall of some hepatic enzymes associated with glutamic acid metabolism. The changes were later normalised during dietary rehabilitation of the protein-deprived rats. The levels of these enzymes were found to be increased as compared to those observed after sta... | Influence of experimental dietary conditions on hepatic enzymes of glutamic acid metabolism in rats. The lowering levels of dietary protein induced a significant fall of some hepatic enzymes associated with glutamic acid metabolism. The changes were later normalised during dietary rehabilitation of the protein-deprived... | [
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PMID:5695 | [Methods of determination of the turnover rate of neuromediators (author's transl)]. | For the study of the effect of a treatment on a neuromediator, the determination of the turnover rate is often more interesting than the determination of the endogenous level of the mediator. Many methods have been used and they are not always isotopic ones. The principal methods are summarized here, especially for cat... | [Methods of determination of the turnover rate of neuromediators (author's transl)]. For the study of the effect of a treatment on a neuromediator, the determination of the turnover rate is often more interesting than the determination of the endogenous level of the mediator. Many methods have been used and they are no... | [
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PMID:5698 | Changes in tyrosine transaminase and phosphoenolpyruvate kinase activities during short term incubation of fetal liver. | Incubation of fetal rat liver homogenates at 37 degrees for 2-3 hr increased PEPK activity in the 100,000 X g supernatant 5-fold and TTA activity 10-fold. At the same time, activity in the 100,000 X g pellet decreaed and no change was observed in the whole homogenate. It is concluded that during incubation of fetal liv... | Changes in tyrosine transaminase and phosphoenolpyruvate kinase activities during short term incubation of fetal liver. Incubation of fetal rat liver homogenates at 37 degrees for 2-3 hr increased PEPK activity in the 100,000 X g supernatant 5-fold and TTA activity 10-fold. At the same time, activity in the 100,000 X g... | [
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PMID:5699 | Oxygen transport in congenital heart disease: influence of fetal hemoglobin, red cell pH, and 2,3-diphosphoglycerate. | In 48 individuals (age 1 day to 13 years) with congenital heart disease, blood oxygen transport function was studied in order to evaluate adaptive changes in shunt hypoxemia and to investigate the in vivo regulation of erythrocyte 2, 3-diphosphoglycerate concentration (RBC 2, 3-DPG) in the presence of fetal hemoglobin ... | Oxygen transport in congenital heart disease: influence of fetal hemoglobin, red cell pH, and 2,3-diphosphoglycerate. In 48 individuals (age 1 day to 13 years) with congenital heart disease, blood oxygen transport function was studied in order to evaluate adaptive changes in shunt hypoxemia and to investigate the in vi... | [
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PMID:5701 | Dual effect of 2,3-diphosphoglycerate on the Bohr effects of human blood. | The influence of the red cell concentration of 2,3-diphosphoglycerate (2,3-DPG, 0.5-26 mumoles/g erythrocytes) on the "CO2-Bohr effect" (pH varied by CO2 at constant base excess) and the "fixed acid-Bohr effect" (pH varied by fixed acid or base at constant PCO2) was studied in human blood at plasma pH values ranging be... | Dual effect of 2,3-diphosphoglycerate on the Bohr effects of human blood. The influence of the red cell concentration of 2,3-diphosphoglycerate (2,3-DPG, 0.5-26 mumoles/g erythrocytes) on the "CO2-Bohr effect" (pH varied by CO2 at constant base excess) and the "fixed acid-Bohr effect" (pH varied by fixed acid or base a... | [
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PMID:5702 | Influence of 2,3-diphosphoglycerate on the buffering properties of human blood: role of the red cell membrane. | The effect of the concentration of red cell 2,3-diphosphoglycerate (2,3-DPG, 0.5-21 mumoles/g cells) on the buffering properties and on the slope of the relation between the extracellular and intracellular pH (deltapHi/deltapHe) of human blood was studied. The results were evaluated in connection with previous findings... | Influence of 2,3-diphosphoglycerate on the buffering properties of human blood: role of the red cell membrane. The effect of the concentration of red cell 2,3-diphosphoglycerate (2,3-DPG, 0.5-21 mumoles/g cells) on the buffering properties and on the slope of the relation between the extracellular and intracellular pH ... | [
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PMID:5705 | Conformation and reactivity of DNA in the complex with proteins. III. Helix-coil transition and conformational studies of model complexes of DNA's with poly-L-histidine. | Differences in the interaction of poly-L-histidine with DNA of various base composition have been demonstrated using melting and CD measurements. The two types of complexes formed with DNA at pH values below the pK of 5.9 and in the region of pH 6.5 are very different in their CD spectral properties. The binding effect... | Conformation and reactivity of DNA in the complex with proteins. III. Helix-coil transition and conformational studies of model complexes of DNA's with poly-L-histidine. Differences in the interaction of poly-L-histidine with DNA of various base composition have been demonstrated using melting and CD measurements. The ... | [
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PMID:5706 | Conformation and reactivity of DNA in the complex with protein. IV. Circular dichroism of poly-L-histidine model complexes with DNA polymers and specificity of the interaction. | The CD study of the DNA-poly-L-histidine complex at high degree of protonation revealed that complex formation is already observable at 2 M NaCl. The influence of salt together with 5 M urea suggests that in addition to electrostatic interactions probably hydrogen bonding may favour specific complexes. Affinity of prot... | Conformation and reactivity of DNA in the complex with protein. IV. Circular dichroism of poly-L-histidine model complexes with DNA polymers and specificity of the interaction. The CD study of the DNA-poly-L-histidine complex at high degree of protonation revealed that complex formation is already observable at 2 M NaC... | [
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PMID:5707 | Effect of excision of the Y-base on the interaction of tRNAPhe (yeast) with phenylalanyl-tRNA synthetase (yeast). | The interaction between tRNAPhe (yeast), from which the Y-base has been removed by acid treatment, and phenylalanyl-tRNA synthetase (yeast) has been investigated by fluorescence competition titrations and sedimentation velocity runs. The binding parameters are given under various ionic conditions. The tRNAPhe-Y still c... | Effect of excision of the Y-base on the interaction of tRNAPhe (yeast) with phenylalanyl-tRNA synthetase (yeast). The interaction between tRNAPhe (yeast), from which the Y-base has been removed by acid treatment, and phenylalanyl-tRNA synthetase (yeast) has been investigated by fluorescence competition titrations and s... | [
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PMID:5708 | Distribution of histones in alkali-denatured chromatin studied by isopycnic centrifugation in alkaline metrizamide density gradients. | Three types of density gradients - neutral metrizamide, alkaline NaOH-metrizamide and alkaline triethanolamine-metrizamide - were used for studying the distribution of histones between the two DNA strands in alkali-denatured chromatin. It was found possible to avoid both protein redistribution and dissociation by using... | Distribution of histones in alkali-denatured chromatin studied by isopycnic centrifugation in alkaline metrizamide density gradients. Three types of density gradients - neutral metrizamide, alkaline NaOH-metrizamide and alkaline triethanolamine-metrizamide - were used for studying the distribution of histones between t... | [
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PMID:5709 | Pyrimidine nucleoside analogues.X. 5-Substituted 1-(1,3-dihydroxypropyl-2) uracils. | A convenient method is suggested for synthesis of uracil-1-malonic acid diethyl ester by alkylating 2,4-bis(trimethylsilyl) uracil with bromo-malonic acid diethyl ester. This compound has been shown to hydrolyze with NaOH yielding either uracil or uracil-1-acetic acid, depending on reaction conditions. Similarly, thymi... | Pyrimidine nucleoside analogues.X. 5-Substituted 1-(1,3-dihydroxypropyl-2) uracils. A convenient method is suggested for synthesis of uracil-1-malonic acid diethyl ester by alkylating 2,4-bis(trimethylsilyl) uracil with bromo-malonic acid diethyl ester. This compound has been shown to hydrolyze with NaOH yielding eithe... | [
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PMID:5710 | Preparation and properties of poly 2'-O-ethylcytidylic acid. | Poly 2'0-ethylcytidylic acid (poly (Ce)) was prepared by polymerization of 2'-0-ethylcytidine-5'-pyrophosphate with Escherichia coli polynucleotide phosphorylase in the presence of Mn++, and its properties compared with those of poly (rC), poly (Cm) and poly (dC). The neutral form of pOLY (Ce) exhibits properties simil... | Preparation and properties of poly 2'-O-ethylcytidylic acid. Poly 2'0-ethylcytidylic acid (poly (Ce)) was prepared by polymerization of 2'-0-ethylcytidine-5'-pyrophosphate with Escherichia coli polynucleotide phosphorylase in the presence of Mn++, and its properties compared with those of poly (rC), poly (Cm) and poly ... | [
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PMID:5711 | O2'-Methylinosine, a constituent of the ribosomal RNA of Crithidia fasciculata. | A novel nucleoside, O2'-methylinosine (Im), has been identified as a constituent of the ribosomal RNA of Crithidia fasciculata, a hemoflaggelate protozoan. The nucleoside is released as part of an alkali-stable dinucleotide, Im-Up, by alkaline hydrolysis of Crithidia rRNA, and as a 5'-nucleotide, pIm, by snake venom hy... | O2'-Methylinosine, a constituent of the ribosomal RNA of Crithidia fasciculata. A novel nucleoside, O2'-methylinosine (Im), has been identified as a constituent of the ribosomal RNA of Crithidia fasciculata, a hemoflaggelate protozoan. The nucleoside is released as part of an alkali-stable dinucleotide, Im-Up, by alkal... | [
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PMID:5720 | Observations and interpretation of x-ray absorption edges in iron compounds and proteins. | X-ray absorption spectra near the Kalpha edge have been measured in various iron group compounds using the intense synchrotron radiation at the Stanford Synchrotron Research Project. In the cubic compounds KMF3 where M = Mn+2, Fe+2, Co+2, Ni+2, and Zn+2, well resolved lines were observed and assigned to the 1s leads to... | Observations and interpretation of x-ray absorption edges in iron compounds and proteins. X-ray absorption spectra near the Kalpha edge have been measured in various iron group compounds using the intense synchrotron radiation at the Stanford Synchrotron Research Project. In the cubic compounds KMF3 where M = Mn+2, Fe+... | [
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PMID:5721 | Nuclear magnetic resonance studies of slowly exchanging peptide protons in cytochrome c in aqueous solution. | The slowly exchanging protons in oxidized and reduced horse heart cytochrome c (D20, uncorrected pH meter reading 6.5 room temperature) have been monitored by recording the 270 and 360 MHz proton nuclear magnetic resonance spectra of the reduced protein between 5 and 11 parts per million downfield from 2,2-dimethyl-2-s... | Nuclear magnetic resonance studies of slowly exchanging peptide protons in cytochrome c in aqueous solution. The slowly exchanging protons in oxidized and reduced horse heart cytochrome c (D20, uncorrected pH meter reading 6.5 room temperature) have been monitored by recording the 270 and 360 MHz proton nuclear magneti... | [
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PMID:5722 | 15N nuclear magnetic resonance investigations on amino acids. | 15N nuclear magnetic resonance investigations of some amino acids were carried out in order to check the applicability of this method to biological problems. Because the natural abundance of the 15N isotope is not sufficient to get readable spectra in a reasonable time, 95% 15N isotope-enriched samples were used for th... | 15N nuclear magnetic resonance investigations on amino acids. 15N nuclear magnetic resonance investigations of some amino acids were carried out in order to check the applicability of this method to biological problems. Because the natural abundance of the 15N isotope is not sufficient to get readable spectra in a reas... | [
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PMID:5723 | Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. | Incubation of purified frog erythrocyte membranes with beta-adrenergic agonists at 25 degrees produces relatively rapid (half-time about 10 min) desensitization (inactivation) of about 60% of the beta-adrenergic receptor binding sites. The desensitized receptors no longer bind the specific beta-adrenergic ligand (-)[3H... | Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. Incubation of purified frog erythrocyte membranes with beta-adrenergic agonists at 25 degrees produces relatively rapid (half-time... | [
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PMID:5724 | An assay of ribonuclease H, endoribonucleases, and phosphatases. | An assay for ribonuclease H (EC 3.1.4.34) is described which permits the estimation of the number and the type of cleavages produced by the enzyme when acting on the ribo moiety of a DNA-RNA hybrid substrate. With six different homopolymer hybrids tested, the number of enzymically induced breaks varied widely. The meth... | An assay of ribonuclease H, endoribonucleases, and phosphatases. An assay for ribonuclease H (EC 3.1.4.34) is described which permits the estimation of the number and the type of cleavages produced by the enzyme when acting on the ribo moiety of a DNA-RNA hybrid substrate. With six different homopolymer hybrids tested,... | [
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PMID:5725 | Bacteriophage T5-induced endonucleases that introduce site-specific single-chain interruptions in duplex DNA. | Four site-specific endodeoxyribonucleases have been partially purified from extracts of bacteriophage T5-infected Escherichia coli by gel filtration and affinity chromatography on single- and double-stranded DNA. The enzymes were detected and characterized by agarose gel electrophoresis of alkali-denatured digestion pr... | Bacteriophage T5-induced endonucleases that introduce site-specific single-chain interruptions in duplex DNA. Four site-specific endodeoxyribonucleases have been partially purified from extracts of bacteriophage T5-infected Escherichia coli by gel filtration and affinity chromatography on single- and double-stranded DN... | [
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PMID:5726 | Regulation of guanylate and adenylate cyclase activities by lysolecithin. | The guanylate cyclase activity [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] in membrane preparations from 3T3 mouse fibroblasts is stimulated approximately 5-fold by lysolecithin at concentrations of 100 mug/ml and above. | Regulation of guanylate and adenylate cyclase activities by lysolecithin. The guanylate cyclase activity [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] in membrane preparations from 3T3 mouse fibroblasts is stimulated approximately 5-fold by lysolecithin at concentrations of 100 mug/ml and above. | [
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PMID:5727 | Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation. | Mice with the X-chromosomal sparse-fur (spf) mutation frequently have urinary bladder stones composed mostly of orotic acid, which was identified by the following criteria: ultraviolet and infrared absorption, spectra, chromatographic behavior, melting point, and reactivity in a specific color test. This clue led to th... | Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation. Mice with the X-chromosomal sparse-fur (spf) mutation frequently have urinary bladder stones composed mostly of orotic acid, which was identified by the following criteria: ultraviolet and infrared absorption, spectra, chromatographic behav... | [
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PMID:5737 | The structure and function of thoracic exopodites in the larvae of the lobster Homarus gammarus (L.). | The first three larval stages of the lobster Homarus gammarus are pelagic swimming animals. A description is given of the exopodite apparatus of the thoracic appendages that provide lift and propulsive power in these stages. Setal arrangement and display provides greater surface area during power strokes. Musculature i... | The structure and function of thoracic exopodites in the larvae of the lobster Homarus gammarus (L.). The first three larval stages of the lobster Homarus gammarus are pelagic swimming animals. A description is given of the exopodite apparatus of the thoracic appendages that provide lift and propulsive power in these s... | [
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PMID:5738 | A quantitative analysis of exopodite beating in the larvae of the lobster Homarus gammarus (L.). | Raw data on exopodite beating in the first three developmental stages of the lobster Homarus gammarus were collected and analysed for key beating parameters. The analysis was computer assisted and the main procedures used are described. Beating patterns are the same in all three stages and are usually very regular alth... | A quantitative analysis of exopodite beating in the larvae of the lobster Homarus gammarus (L.). Raw data on exopodite beating in the first three developmental stages of the lobster Homarus gammarus were collected and analysed for key beating parameters. The analysis was computer assisted and the main procedures used a... | [
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PMID:5739 | A comparison of beating parameters in larval and post-larval locomotor systems of the lobster Homarus gammarus (L.). | A study has been made of the interrelations between rhythmical exopodite beating in different larval stages and swimmeret beating in poast-larval stages of the lobster Homarus gammarus. Data on exopodite beat cycle durations have been used for statistical comparisons of exopodite performance within one larva, and also ... | A comparison of beating parameters in larval and post-larval locomotor systems of the lobster Homarus gammarus (L.). A study has been made of the interrelations between rhythmical exopodite beating in different larval stages and swimmeret beating in poast-larval stages of the lobster Homarus gammarus. Data on exopodite... | [
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PMID:5740 | The nervous system of Loligo. II. Suboesophageal centres. | A well-marked hierarchy of centres can be recognized within the suboesophageal lobes and ganglia of the arms. The inputs and outputs of each lobe are described. There are sets of motoneurons and intermediate motor centres, which can be activated either from the periphery or from above. They mostly do not send fibres up... | The nervous system of Loligo. II. Suboesophageal centres. A well-marked hierarchy of centres can be recognized within the suboesophageal lobes and ganglia of the arms. The inputs and outputs of each lobe are described. There are sets of motoneurons and intermediate motor centres, which can be activated either from the ... | [
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PMID:5741 | Psychoactive drugs. Uses, misuses, and abuses. | The source of knowledge about the use of psychoactive drugs is often biased--being the representative or literature of the pharmaceutical company. Psychotropic drugs and their appropriate usage are discussed, and the basic ingredients of good prescribing habits are examined by focusing on the nonchemical factors that c... | Psychoactive drugs. Uses, misuses, and abuses. The source of knowledge about the use of psychoactive drugs is often biased--being the representative or literature of the pharmaceutical company. Psychotropic drugs and their appropriate usage are discussed, and the basic ingredients of good prescribing habits are examine... | [
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PMID:5742 | Understanding acid-base disturbances. | The physiologic principles of blood pH, Pco2, and bicarbonate homeostasis provide a suitable basis for a systematic approach to the interpretation of acid-base disturbances. Pathogenesis, diagnosis, and management of the four classic acid-base disorders follows. | Understanding acid-base disturbances. The physiologic principles of blood pH, Pco2, and bicarbonate homeostasis provide a suitable basis for a systematic approach to the interpretation of acid-base disturbances. Pathogenesis, diagnosis, and management of the four classic acid-base disorders follows. | [
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PMID:5743 | Dystonic reactions following neuroleptics: time course and proposed mechanisms. | The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dyst... | Dystonic reactions following neuroleptics: time course and proposed mechanisms. The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 5... | [
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PMID:5753 | Lysosomal and neutral hydrolase activity during the regression of cardiac hypertrophy. | Cardiac hypertrophy was produced in rats by constriction of the ascending aorta. Removal of the constricting band 10 days after operation resulted in rapid decline in left ventricular (LV) weight and total ventricular RNA. Activities of acid RNase and beta-glucuronidase were elevated 3 days after aortic constriction. A... | Lysosomal and neutral hydrolase activity during the regression of cardiac hypertrophy. Cardiac hypertrophy was produced in rats by constriction of the ascending aorta. Removal of the constricting band 10 days after operation resulted in rapid decline in left ventricular (LV) weight and total ventricular RNA. Activities... | [
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PMID:5754 | Reduced myocardial ATP and creatine phosphate in diabetes: role of 2,3-diphosphoglycerate. | Observations are presented which suggest that myocardial cellular hypoxia may account for the reduction in myocardial ATP and CP in the ketoacidotic diabetic state. It is suggested that reduced 2,3-diphosphoglycerate adversely affects oxygen release from the red blood cell, thereby leading to myocardial cellular hypoxi... | Reduced myocardial ATP and creatine phosphate in diabetes: role of 2,3-diphosphoglycerate. Observations are presented which suggest that myocardial cellular hypoxia may account for the reduction in myocardial ATP and CP in the ketoacidotic diabetic state. It is suggested that reduced 2,3-diphosphoglycerate adversely af... | [
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PMID:5755 | Early changes in myocardial hypoxia: relations among mechanical function, pH, and intracellular redox states. | When rat hearts were subjected to abrupt hypoxia the onset of NADH changes as measured by epicardial fluorescence and of depressed contractility occurred at similar times. Direct measurements of changes in tissue metabolism lagged behind changes in fluorescence and contractility. Calculated NAD:NADH ratios became reduc... | Early changes in myocardial hypoxia: relations among mechanical function, pH, and intracellular redox states. When rat hearts were subjected to abrupt hypoxia the onset of NADH changes as measured by epicardial fluorescence and of depressed contractility occurred at similar times. Direct measurements of changes in tiss... | [
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PMID:5756 | Inhibition of glycolysis in hearts during ischemic perfusion. | Rates of glycolysis were determined in the isolated perfused rat heart under aerobic, anoxic, and ischemic conditions. The rate was accelerated in anoxic and was inhibited in ischemic tissue. Glycolytic inhibition developed at the level of glyceraldehyde-3-P dehydrogenase and was associated with accumulation of high le... | Inhibition of glycolysis in hearts during ischemic perfusion. Rates of glycolysis were determined in the isolated perfused rat heart under aerobic, anoxic, and ischemic conditions. The rate was accelerated in anoxic and was inhibited in ischemic tissue. Glycolytic inhibition developed at the level of glyceraldehyde-3-P... | [
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PMID:5759 | Muscarinic stimulation of cardiac guanylate cyclase. | Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (db-cAMP) at varying concentrations from 1 X 10(-4) M to 1 X 10(-3) M. A positive inotropic effect was observed with all concentrations of db-cAMP. Concomitant administration of 5 X 10(-4) M monobutyryl guanosine 3',5... | Muscarinic stimulation of cardiac guanylate cyclase. Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (db-cAMP) at varying concentrations from 1 X 10(-4) M to 1 X 10(-3) M. A positive inotropic effect was observed with all concentrations of db-cAMP. Concomitant admi... | [
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PMID:5760 | Distribution of lysosome populations in rat cardiac tissue. | The post-nuclear fraction of rat heart tissue was fractionated by isopycnic zonal centrifugation in sucrose gradients, followed by differential centrifugation of the zonal fractions (rho-S fractionation). The distribution of 5 lysosomal acid hydrolases, a protease with neutral and alkaline activity and several marker e... | Distribution of lysosome populations in rat cardiac tissue. The post-nuclear fraction of rat heart tissue was fractionated by isopycnic zonal centrifugation in sucrose gradients, followed by differential centrifugation of the zonal fractions (rho-S fractionation). The distribution of 5 lysosomal acid hydrolases, a prot... | [
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PMID:5761 | Phospholipase A and acid lipase activity during release of lysosomal hydrolases. | Hydrolysis of cardiac and hepatic lysosomal phospholipids by endogenous phospholipase A occurs during incubation at 37 degrees C at pH 5.0. Lysophospholipids and free fatty acids accumulate in association with release of hydrolases from the lysosomes into the supernatant. Acid-active neutral lipid lipases contribute to... | Phospholipase A and acid lipase activity during release of lysosomal hydrolases. Hydrolysis of cardiac and hepatic lysosomal phospholipids by endogenous phospholipase A occurs during incubation at 37 degrees C at pH 5.0. Lysophospholipids and free fatty acids accumulate in association with release of hydrolases from th... | [
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PMID:5762 | Some properties of rat myocardial ornithine decarboxylase and the in vitro effects of nucleotides. | Myocardial ornithine decarboxylase appears to have characteristics similar to those of enzymes isolated from other tissues. Ornithine decarboxylase activity decreased very rapidly after the death of the animal. Storage of the cell sap fraction at 0 degrees C or -15 degrees C, however, led to only a small decrease in th... | Some properties of rat myocardial ornithine decarboxylase and the in vitro effects of nucleotides. Myocardial ornithine decarboxylase appears to have characteristics similar to those of enzymes isolated from other tissues. Ornithine decarboxylase activity decreased very rapidly after the death of the animal. Storage of... | [
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PMID:5763 | Comparative aspects of buffering capacity in muscle. | These findings are discussed in relation to the contention that a high buffer value is linked to a high work performance. This generalization does not extend to the "white" breast muscle of chicken. Its high buffer value is in part due to a high content of the dipeptides carnosine and anserine. Additionally, a hypothes... | Comparative aspects of buffering capacity in muscle. These findings are discussed in relation to the contention that a high buffer value is linked to a high work performance. This generalization does not extend to the "white" breast muscle of chicken. Its high buffer value is in part due to a high content of the dipept... | [
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PMID:5764 | Cardiac and skeletal muscle acid-base composition during metabolic acidosis in dogs. | Nephrectomized, open chested dogs were infused with 25-30 ml.kg(-1) body weight of 0.15 M NaCl (group I), 0.15 MHCl (Group II) or 0.3 M lactic acid (Group) III). Pulmonary ventilation was maintained constant in the three groups. Intracellular pH was calculated with the CO2 method. No significant intracellular or extrac... | Cardiac and skeletal muscle acid-base composition during metabolic acidosis in dogs. Nephrectomized, open chested dogs were infused with 25-30 ml.kg(-1) body weight of 0.15 M NaCl (group I), 0.15 MHCl (Group II) or 0.3 M lactic acid (Group) III). Pulmonary ventilation was maintained constant in the three groups. Intrac... | [
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PMID:5765 | Dependence of CSF on plasma bicarbonate during hypocapnia and hypoxemic hypocapnia. | We have previoulsy shown pH compensation to be similar in CSF and arterial blood during chronic hypoxemic hypocapnia in man and pony, and postulated that the compensatory reduction in CSF [HCO3] was dependent upon corresponding changes in [HCO3]a. We tested this hypothesis in anesthetized, paralyzed dogs by determining... | Dependence of CSF on plasma bicarbonate during hypocapnia and hypoxemic hypocapnia. We have previoulsy shown pH compensation to be similar in CSF and arterial blood during chronic hypoxemic hypocapnia in man and pony, and postulated that the compensatory reduction in CSF [HCO3] was dependent upon corresponding changes ... | [
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PMID:5770 | Response to jejunal acidification in man. I. Changes in composition of perfusate. | The jejunal disposal of perfused acid was studied in 11 control subjects and 12 patients with duodenal ulcer. It was found that the capacity to dispose of acid was saturable and was less than control in patients with duodenal ulcer. When the load of acid was small, all the acid disappeared from the jejunum and sodium b... | Response to jejunal acidification in man. I. Changes in composition of perfusate. The jejunal disposal of perfused acid was studied in 11 control subjects and 12 patients with duodenal ulcer. It was found that the capacity to dispose of acid was saturable and was less than control in patients with duodenal ulcer. When ... | [
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PMID:5771 | The hydrolysis and absorption of conjugated folates in man. | After ingestion of synthetic PteGlu3 in physiological doses, the folate forms were studied in plasma obtained from human vena portae blood. Plasma conjugase was inhibited by rapid heat-denaturation. The folate forms were assayed with L. casei and S. faecalis and identified by thin-layer chromatography (biautography). M... | The hydrolysis and absorption of conjugated folates in man. After ingestion of synthetic PteGlu3 in physiological doses, the folate forms were studied in plasma obtained from human vena portae blood. Plasma conjugase was inhibited by rapid heat-denaturation. The folate forms were assayed with L. casei and S. faecalis a... | [
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PMID:5772 | Erythroid differentiation of fetal, newborn and adult haemopoietic stem cells. | Erythroid regeneration was studied in lethally irradiated mice given transplants containing equivalent numbers of haemopoietic stem cells (i.e. CFU) from fetal liver, neonatal marrow or adult marrow. Adult marrow was taken from normal control mice, whose CFU for the most part were not in active cell cycle, as well as f... | Erythroid differentiation of fetal, newborn and adult haemopoietic stem cells. Erythroid regeneration was studied in lethally irradiated mice given transplants containing equivalent numbers of haemopoietic stem cells (i.e. CFU) from fetal liver, neonatal marrow or adult marrow. Adult marrow was taken from normal contro... | [
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PMID:5773 | Serological types of Diplococcus pneumoniae isolated from the respiratory tract of children with cystic fibrosis and children with other diseases. | The distribution of serological types of D. pneumoniae was investigated in 40 strains isolated from 26 children with cystic fibrosis and 57 strains isolated from 39 children with other diseases. All strains were isolated from sputum or tracheal secretion. The strains from cystic fibrosis patients belonged to 14 differe... | Serological types of Diplococcus pneumoniae isolated from the respiratory tract of children with cystic fibrosis and children with other diseases. The distribution of serological types of D. pneumoniae was investigated in 40 strains isolated from 26 children with cystic fibrosis and 57 strains isolated from 39 children... | [
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PMID:5774 | Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension. | Discrete brain areas and sympathetic ganglia obtained at autopsy from patients with idiopathic orthostatic hypotension were assayed for tyrosine hydroxylase and dopamine beta-hydroxylase. Dopamine beta-hydroxylase activity was decreased 7.5-fold in sympathetic ganglia, while tyrosine hydroxylase activity was reduced mo... | Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension. Discrete brain areas and sympathetic ganglia obtained at autopsy from patients with idiopathic orthostatic hypotension were assayed for tyrosine hydroxylase and dopamine beta-hydroxylase. Dopamine beta-hydroxylase activit... | [
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PMID:5775 | Lymphocyte-induced angiogenesis in tumor-bearing mice. | The presence of a growing tumor can lead to a significant curtailment of a graft-versus-host reaction as measured by the ability of allogeneic spleen cells to induce a host vascular response. This interference with the normal pattern of immunological reactions may be a reason for the survival of tumors in an immunologi... | Lymphocyte-induced angiogenesis in tumor-bearing mice. The presence of a growing tumor can lead to a significant curtailment of a graft-versus-host reaction as measured by the ability of allogeneic spleen cells to induce a host vascular response. This interference with the normal pattern of immunological reactions may ... | [
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PMID:5782 | Clinical significance of the biotransformation of inhalation anesthetics. | Inhalation anesthetics, a class of drugs formerly believed to be biologically inert, are now recognized to undergo considerable biotransformation. The viscerotoxicity of certain anesthetics on kidney and liver can be explained in terms of metabolism. The entity of "halothane hepatitis" remains mechanistically and diagn... | Clinical significance of the biotransformation of inhalation anesthetics. Inhalation anesthetics, a class of drugs formerly believed to be biologically inert, are now recognized to undergo considerable biotransformation. The viscerotoxicity of certain anesthetics on kidney and liver can be explained in terms of metabol... | [
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PMID:5783 | Theoretical considerations in the vector control of filariasis. | In order to assist in assessing progress of vector control of filariasis a theoretical model is constructed, using retrospective data on infected persons removed to a vector-free situation. This shows that the decrease of microfilaraemia is not regular, but is gradual for the first 3 years and then more rapid, reaching... | Theoretical considerations in the vector control of filariasis. In order to assist in assessing progress of vector control of filariasis a theoretical model is constructed, using retrospective data on infected persons removed to a vector-free situation. This shows that the decrease of microfilaraemia is not regular, bu... | [
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PMID:5785 | Intensive care in a hospital for Blacks. A review of 300 consecutive admissions. | Experinece with the first 300 patients in a new Intensive Care Unit for Blacks is presented. Causes of death and specific problems are considered in detail. | Intensive care in a hospital for Blacks. A review of 300 consecutive admissions. Experinece with the first 300 patients in a new Intensive Care Unit for Blacks is presented. Causes of death and specific problems are considered in detail. | [
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PMID:5786 | The management of hernias, hydroceles and undescended testes. | The management of hernias, hydroceles and undescended testicles is reviewed on the basis of current practice as reported in recent literature and of the author's experience at Addington Hospital, Durban. | The management of hernias, hydroceles and undescended testes. The management of hernias, hydroceles and undescended testicles is reviewed on the basis of current practice as reported in recent literature and of the author's experience at Addington Hospital, Durban. | [
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PMID:5793 | Experimental stimulation of cell-mediated immunity without concomitant stimulation of humoral immunity in graft-versus-host immunosuppressed mice. | The immunosuppressive effect of the graft-versus-host (GVH) reaction was studied in CBA X A F1 (CAF1) mice which had been rendered immunologically unresponsive by the injection of parental A strain lymphoid cells (GVH mice). Suppression of both cell-mediated and humoral immune responses was demonstrated by the prolonge... | Experimental stimulation of cell-mediated immunity without concomitant stimulation of humoral immunity in graft-versus-host immunosuppressed mice. The immunosuppressive effect of the graft-versus-host (GVH) reaction was studied in CBA X A F1 (CAF1) mice which had been rendered immunologically unresponsive by the inject... | [
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PMID:5794 | [The hematopoietic colony-forming cell--object of experimental study]. | Studies dealing with the colony-forming cell as a subject of experimental research are reviewed. The techniques of cultivation of colony-forming cells, their proliferation, differentiation and self-renewal have been considered. | [The hematopoietic colony-forming cell--object of experimental study]. Studies dealing with the colony-forming cell as a subject of experimental research are reviewed. The techniques of cultivation of colony-forming cells, their proliferation, differentiation and self-renewal have been considered. | [
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PMID:5796 | Abnormal liver enzymes and human chorionic gonadotropin elevation in abdominal testicular seminoma. | A case of seminoma in an abdominal testis is presented in which abnormal liver enzyme as well as elevated human chorionic gonadotropin levels were present which returned to normal after surgical extirpation of the primary lesion. A review of pertinent literature and implications of these unusual findings are presented. | Abnormal liver enzymes and human chorionic gonadotropin elevation in abdominal testicular seminoma. A case of seminoma in an abdominal testis is presented in which abnormal liver enzyme as well as elevated human chorionic gonadotropin levels were present which returned to normal after surgical extirpation of the primar... | [
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PMID:5801 | [Clinical evaluation of the effectiveness of different surgical interventions in peptic ulcer]. | The clinical status, secretory and motor activity of the stomach were studied in 213 patients showing ulcerous disease prior to surgery and in 153 operated patients. The most favourable results were noted after resection of two thirds of the stomach in Billroth I modification with preservation of the pyloric compressor... | [Clinical evaluation of the effectiveness of different surgical interventions in peptic ulcer]. The clinical status, secretory and motor activity of the stomach were studied in 213 patients showing ulcerous disease prior to surgery and in 153 operated patients. The most favourable results were noted after resection of ... | [
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PMID:5802 | [Comparative study of the optimum pH value of serum alkaline phosphatase in various species of farm animals]. | Investigations were carried out on the alkaline phosphatase in the sera of cattle, horses, pigs, sheep, goats, and chickens, the pH value of the buffer used being 9.0-9.8-10.0-10.2-10.6 and 11.0, and the method applied--that of Richterich. The pH value at which the serum alkaline phosphatase in the various farm animals... | [Comparative study of the optimum pH value of serum alkaline phosphatase in various species of farm animals]. Investigations were carried out on the alkaline phosphatase in the sera of cattle, horses, pigs, sheep, goats, and chickens, the pH value of the buffer used being 9.0-9.8-10.0-10.2-10.6 and 11.0, and the method... | [
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PMID:5809 | The electrolyte pattern of the gastric secretion from the vervet monkey. | The output of acid, chloride, sodium and potassium in gastric washings from the Vervet monkey have been measured under basal conditions and while stimulating the secretion with two doses of pentagastrin (one dose submaximal, the other dose supramaximal). The output during washings with different weak electrolyte soluti... | The electrolyte pattern of the gastric secretion from the vervet monkey. The output of acid, chloride, sodium and potassium in gastric washings from the Vervet monkey have been measured under basal conditions and while stimulating the secretion with two doses of pentagastrin (one dose submaximal, the other dose suprama... | [
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PMID:5811 | [The acid-base balance in the CSF of normal subjects regulatory mechanisms (author's transl)]. | 1. The acid-base balance (pH, pCO2 and HCO-3) of 23 normal subjects was determined both in arterialized capillary blood and in the CSF. 2. Statistically significant correlations (determined by means of Spearman's rank correlation) were found between: pCO2 in arterialized blood and CSF pH (Rs=--0.372, p is less than 0.0... | [The acid-base balance in the CSF of normal subjects regulatory mechanisms (author's transl)]. 1. The acid-base balance (pH, pCO2 and HCO-3) of 23 normal subjects was determined both in arterialized capillary blood and in the CSF. 2. Statistically significant correlations (determined by means of Spearman's rank correla... | [
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PMID:5812 | [The diagnosis of cholestasis: lipoprotein X (LP-X) (author's transl)]. | The diagnostic specificity of a new method to detect obstructive jaundice by determination of lipoprotein X (LP-X) was tested in 144 patients with different kinds of hepatic diseases and compared with the usual chemical "obstructive jaundice specific" tests, such as bilirubin, SGOT, SGPT, alkaline phosphatase, LAP and ... | [The diagnosis of cholestasis: lipoprotein X (LP-X) (author's transl)]. The diagnostic specificity of a new method to detect obstructive jaundice by determination of lipoprotein X (LP-X) was tested in 144 patients with different kinds of hepatic diseases and compared with the usual chemical "obstructive jaundice specif... | [
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PMID:5813 | [The effects of flunitrazepam (rohypnol) on respiration (author's transl)]. | The effects of flunitrazepam (0.03 mg/kg administered intravenously over a two-minute period) was investigated in 11 healthy volunteers with normal pulmonary function. Spirometer tracings were recorded continuously by the Siregnost FD 40 and blood gas measurements were performed by the Harnoncourt AVL gas analyzer. Flu... | [The effects of flunitrazepam (rohypnol) on respiration (author's transl)]. The effects of flunitrazepam (0.03 mg/kg administered intravenously over a two-minute period) was investigated in 11 healthy volunteers with normal pulmonary function. Spirometer tracings were recorded continuously by the Siregnost FD 40 and bl... | [
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PMID:5814 | [Immunosuppressive therapy in renal disease (author's transl)]. | Since immunological events were found to be pathogenetically involved in various forms of glomerulonephritis, corticosteroids and immunosuppressive drugs were introduced in the treatment of nephritis. However, as opposed to the findings in the paediatric nephrotic syndrome, controlled and multicentric trials with immun... | [Immunosuppressive therapy in renal disease (author's transl)]. Since immunological events were found to be pathogenetically involved in various forms of glomerulonephritis, corticosteroids and immunosuppressive drugs were introduced in the treatment of nephritis. However, as opposed to the findings in the paediatric n... | [
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PMID:5815 | [Infusion therapy with mif (melanocyte inhibiting factor) in Parkinson's disease (author's transl)]. | On the basis of reports in the literature and of our own clinical experience it appears that melanocyte inhibiting factor (MIF) is a very promising therapeutic agent in the management of Parkinson's disease. Besides theoretical considerations relating to biochemical and pathophysiological spheres, the question of the c... | [Infusion therapy with mif (melanocyte inhibiting factor) in Parkinson's disease (author's transl)]. On the basis of reports in the literature and of our own clinical experience it appears that melanocyte inhibiting factor (MIF) is a very promising therapeutic agent in the management of Parkinson's disease. Besides the... | [
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PMID:5822 | Implication of rifampicin-quinone in the irreversible binding of rifampicin to macromolecules. | 1. When [3H]rifampicin is incubated with rat liver microsomes or rat liver homogenate, minor amounts are bound irreversibly to protein. This effect does not depend on the presence of NAD, NADH, NADP or NADPH. 2. Rifampicin is autoxidized at physiological pH. The product of autoxidation, rifampicin-quinone, if incubated... | Implication of rifampicin-quinone in the irreversible binding of rifampicin to macromolecules. 1. When [3H]rifampicin is incubated with rat liver microsomes or rat liver homogenate, minor amounts are bound irreversibly to protein. This effect does not depend on the presence of NAD, NADH, NADP or NADPH. 2. Rifampicin is... | [
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PMID:5823 | [Bacteriological examinations of bronchial secretion in children with non-specific bronchopulmonary disease (author's transl)]. | One thousand specimens of bronchial secretion from children with non-specific respiratory diseases have been examined bacteriologically. In spite of the complex nature of acute and especially of chronic respiratory disease the role of bacterial infection should not be underestimated. Thirty per cent of the specimens we... | [Bacteriological examinations of bronchial secretion in children with non-specific bronchopulmonary disease (author's transl)]. One thousand specimens of bronchial secretion from children with non-specific respiratory diseases have been examined bacteriologically. In spite of the complex nature of acute and especially ... | [
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PMID:5830 | Biochemical and histochemical studies on non-specific phosphomonoesterases of swine kidney worm Stephanurus dentatus (Diesing, 1839). | Biochemical and histochemical studies have been made on non-specific acid and alkaline phosphomonoesterases of S. dentatus. The two forms of acid phosphomonoesterases have been found active at pH 4.0 and 6.0. The pH optima for the two forms of aklaline phosphomonoesterases lie at 8.0 and 10.0. Studies on the distributi... | Biochemical and histochemical studies on non-specific phosphomonoesterases of swine kidney worm Stephanurus dentatus (Diesing, 1839). Biochemical and histochemical studies have been made on non-specific acid and alkaline phosphomonoesterases of S. dentatus. The two forms of acid phosphomonoesterases have been found act... | [
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0.0430... |
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