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PMID:6288 | Competitive oxidation of 6-hydroxydopamine by oxygen and hydrogen peroxide. | Simultaneous oxygen electrode and conventional polarographic measurements show the net concentration of hydrogen peroxide produced by air oxidation of 6-hydroxydopamine is considerably less than that predicted from the known stoichiometry of the reaction. This is due to competitive oxidation of 6-hydroxydopamine by the... | Competitive oxidation of 6-hydroxydopamine by oxygen and hydrogen peroxide. Simultaneous oxygen electrode and conventional polarographic measurements show the net concentration of hydrogen peroxide produced by air oxidation of 6-hydroxydopamine is considerably less than that predicted from the known stoichiometry of th... | [
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PMID:6289 | Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects. | Using a food-reinforced two-lever operant method, rats (n = 12) were trained to discriminate chlordiazepoxide (5 mg/kg, p.o.) from solvent (p.o.). With rats trained thus as subjects, generalization experiments were done with various benzodiazepines, barbiturates and related compounds, and with two neuroleptic drugs. Th... | Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects. Using a food-reinforced two-lever operant method, rats (n = 12) were trained to discriminate chlordiazepoxide (5 mg/kg, p.o.) from solvent (p.o.). With rats tra... | [
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PMID:6290 | Studies on the centrally mediated hypotensive activity of guanabenz. | Prior studies demonstrated that guanabenz reduces systemic blood pressure by inhibiting central sympathetic outflow as well as by adrenergic neuron blockade. Potential mechanisms responsible for the reduction of efferent sympathetic activity were examined in the present series. Guanabenz failed to modify carotid sinus ... | Studies on the centrally mediated hypotensive activity of guanabenz. Prior studies demonstrated that guanabenz reduces systemic blood pressure by inhibiting central sympathetic outflow as well as by adrenergic neuron blockade. Potential mechanisms responsible for the reduction of efferent sympathetic activity were exam... | [
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PMID:6291 | Modification and characterization of the permanent sympathectomy produced by the administration of guanethidine to newborn rats. | The administration of guanethidine to newborn rats has been shown to produce a permanent sympathectomy with potential advantages over immunosympathectomy and 6-hydroxydopamine-induced chemical sympathectomy. In this paper, we report on a revised treatment regimen involving initiation of treatment (50 mg/kg/day) on day ... | Modification and characterization of the permanent sympathectomy produced by the administration of guanethidine to newborn rats. The administration of guanethidine to newborn rats has been shown to produce a permanent sympathectomy with potential advantages over immunosympathectomy and 6-hydroxydopamine-induced chemica... | [
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PMID:6292 | Studies on the mechanism of the cardiovascualr effects of methyldopa. | Oral administration of methyldopa (100 mg/kg, twice daily for 3 days) to mongrel dogs produced a significant decrease in blood pressure and heart rate. The drug treatment affected neither the resting venous tone nor the cardiac output. Thus, the hypotensive effect of the drug was predominantly due to a reduction in tot... | Studies on the mechanism of the cardiovascualr effects of methyldopa. Oral administration of methyldopa (100 mg/kg, twice daily for 3 days) to mongrel dogs produced a significant decrease in blood pressure and heart rate. The drug treatment affected neither the resting venous tone nor the cardiac output. Thus, the hypo... | [
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PMID:6293 | Some adrenergic beta-blocking agents affecting lipolysis in human adipose tissue in vitro. | Antagonistic actions of beta-blocking drugs on isoproterenol-induced lipolysis were studied in human omental adipose tissue. Competitive interaciton characterized by the following pA2 values was found: propranolol 8.7; trimepranol 8.7; practolol 7.1; H 35/25 6.0. The plot of pA2 values of these drugs for human versus r... | Some adrenergic beta-blocking agents affecting lipolysis in human adipose tissue in vitro. Antagonistic actions of beta-blocking drugs on isoproterenol-induced lipolysis were studied in human omental adipose tissue. Competitive interaciton characterized by the following pA2 values was found: propranolol 8.7; trimeprano... | [
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PMID:6296 | [Observation of bacteriophages in wine (author's transl)]. | Electron microscopic examination of samples of Swiss wine, collected during the malolactic fermentation, revealed the presence of bacteriophages of three different morphological types. It is interesting to note that these phages have been found in a product whose pH is lower than 3.5. | [Observation of bacteriophages in wine (author's transl)]. Electron microscopic examination of samples of Swiss wine, collected during the malolactic fermentation, revealed the presence of bacteriophages of three different morphological types. It is interesting to note that these phages have been found in a product who... | [
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PMID:6297 | Is glutamic acid the pyramidal tract neurotransmitter? | Applied by microiontophoresis, 1-hydroxy-3-amino-pyrrolidone-2 (HA-966) antagonized excitation by glutamic acid but not by acetylcholine of neurones in the rat cuneate nucleus. HA-966 blocked the short latency excitation of cuneate neurones following stimulation of the pyramidal tract on 28 of 40 cells (70%). Thus, glu... | Is glutamic acid the pyramidal tract neurotransmitter? Applied by microiontophoresis, 1-hydroxy-3-amino-pyrrolidone-2 (HA-966) antagonized excitation by glutamic acid but not by acetylcholine of neurones in the rat cuneate nucleus. HA-966 blocked the short latency excitation of cuneate neurones following stimulation of... | [
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PMID:6298 | Effects of physalaemin, a vaso-active peptide from amphibian skin, on the excitability of an identifiable molluscan giant neurone of Achatina fulica Férussac. | We examined effects of several vasoactive peptides (substance P, physalaemin, neurotensin, bradykinin, angiotensin etc.) on the excitability of molluscan giant neurones identified in the subesophageal ganglia of Achatina fulica Férussac. Of these peptides, only physalaemin showed a remarkable excitatory effect on a gia... | Effects of physalaemin, a vaso-active peptide from amphibian skin, on the excitability of an identifiable molluscan giant neurone of Achatina fulica Férussac. We examined effects of several vasoactive peptides (substance P, physalaemin, neurotensin, bradykinin, angiotensin etc.) on the excitability of molluscan giant n... | [
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PMID:6299 | Graft-versus-host reaction and lymphoid organs in normally fed and protein-deprived rats. | Lymph node graft-versus-host reaction (GVHR) induced by parental splenic lymphocytes inoculated into hind foot pads of F-1 hybrid rats is correlated with the state of the thymus and the spleen of the recipients. This may explain the depression of the reaction after protracted protein deprivation. Furthermore, GVHR prov... | Graft-versus-host reaction and lymphoid organs in normally fed and protein-deprived rats. Lymph node graft-versus-host reaction (GVHR) induced by parental splenic lymphocytes inoculated into hind foot pads of F-1 hybrid rats is correlated with the state of the thymus and the spleen of the recipients. This may explain t... | [
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PMID:6300 | Cortisone sensitive T-cells in Peyers' patches. | Pretreatment of donor lymphoid cells with cortisone has been shown to depress the T-cell subpopulation responsible for cellular proliferation in the GVH reaction. A quantitative assay as well as the histological criteria of the GVH reaction have been used in this study to demonstrate the presence of cortisone-sensitive... | Cortisone sensitive T-cells in Peyers' patches. Pretreatment of donor lymphoid cells with cortisone has been shown to depress the T-cell subpopulation responsible for cellular proliferation in the GVH reaction. A quantitative assay as well as the histological criteria of the GVH reaction have been used in this study to... | [
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PMID:6294 | [Detection and quantitative estimation of morphine in the urine of drug addicts by combined 2-dimensional thin-layer chromatography and spectrofluorometry]. | Following extraction from urine and thin-layer bidimensional chromatography, the suspected spot of morphine is located by UV examination at 350 nm and eluted with methanol by means of "Eluchrom" apparatus. The dried residue is then subjected to spectrofluorimetric analysis, in definite conditions. This procedure can be... | [Detection and quantitative estimation of morphine in the urine of drug addicts by combined 2-dimensional thin-layer chromatography and spectrofluorometry]. Following extraction from urine and thin-layer bidimensional chromatography, the suspected spot of morphine is located by UV examination at 350 nm and eluted with ... | [
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PMID:6301 | [Comparative evaluation of the antitoxic activity of central nervous system analeptics and their combinations in barbamyl poisoning]. | Tests conducted on rats poisoned with increasingly lethal doses of sodium amytal demonstrated the antitoxic activity of an analeptic mixture to be superior to that of picrotoxin, strichnine, corasol and caffeine entering into its composition and also to the activity of bemegride. As to the degree of antitoxic activity ... | [Comparative evaluation of the antitoxic activity of central nervous system analeptics and their combinations in barbamyl poisoning]. Tests conducted on rats poisoned with increasingly lethal doses of sodium amytal demonstrated the antitoxic activity of an analeptic mixture to be superior to that of picrotoxin, strichn... | [
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PMID:6302 | [Effect of 1,4-benzodiazepine derivatives on the toxic action of oxygen under increased pressure]. | The 1,4-benzodiazepine derivatives (diazepam, nitrazepm, lorazepam, clonazepam and two newly synthetized compounds of this series) increase the resistance of albino rats and rabbits to the toxic effect of oxygen under high pressure (7 and 5.5 atm respectively). The compounds under study are apt to avert over a long per... | [Effect of 1,4-benzodiazepine derivatives on the toxic action of oxygen under increased pressure]. The 1,4-benzodiazepine derivatives (diazepam, nitrazepm, lorazepam, clonazepam and two newly synthetized compounds of this series) increase the resistance of albino rats and rabbits to the toxic effect of oxygen under hig... | [
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PMID:6304 | [Effect of noninhalant anesthetics on the conduction of excitation in the ventrolateral columns of the cat spinal cord]. | Acute tests on spinal cats were set up to enquire into the effect produced by sodium oxybutyrate, hexobarbital sodium and viadril used in anesthetic doses on the evoked responses in the ventrolateral columns of the spinal cord following stimulation of the skin and pelvic nerves with single and paired stimuli at an inte... | [Effect of noninhalant anesthetics on the conduction of excitation in the ventrolateral columns of the cat spinal cord]. Acute tests on spinal cats were set up to enquire into the effect produced by sodium oxybutyrate, hexobarbital sodium and viadril used in anesthetic doses on the evoked responses in the ventrolateral... | [
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PMID:6305 | [Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions]. | Cytochemical electron microscopy was employed to study the content of neurotransmitters in the synaptic vesicles of adrenergic nerve fibers of Vas deferens of the rat following depletion of the meadiator's reserves by tyramine and subsequent accumulation of exogenous norepinephrine. Subject to investigation was also th... | [Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions]. Cytochemical electron microscopy was employed to study the content of neurotransmitters in the synaptic vesicles of adrenergic nerve fibers of Vas deferens of the rat following depletion of the meadiator's reserve... | [
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PMID:6306 | [Effect of some phenothiazine derivatives on kidney function]. | Chlorathizin and Chlormorphathizin are shown to exercise in 24-hours long tests a substantial diuretic and saluretic action on rats and dogs. Fluorathizin, as well as imizine inhibited the urinary flow. Diprazine augmented the urinary output in dogs, but depressed it in rats. The new antidepressive drug azaphen did not... | [Effect of some phenothiazine derivatives on kidney function]. Chlorathizin and Chlormorphathizin are shown to exercise in 24-hours long tests a substantial diuretic and saluretic action on rats and dogs. Fluorathizin, as well as imizine inhibited the urinary flow. Diprazine augmented the urinary output in dogs, but de... | [
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PMID:6303 | [Effect of psychotropic and anticonvulsive preparations on transport ATPase in the renal tubules of the guinea pig]. | The effect of 4 groups of medicamentous agents, viz. neoruleptics, tricyclic antidepressants, somnifacients and antiepileptics - on the activity of the transport ATPase and p-nitrophenylphosphatase from the renal tubules of the guinea pig was studied. Used in high concentrations neuroleptics suppress almost completely ... | [Effect of psychotropic and anticonvulsive preparations on transport ATPase in the renal tubules of the guinea pig]. The effect of 4 groups of medicamentous agents, viz. neoruleptics, tricyclic antidepressants, somnifacients and antiepileptics - on the activity of the transport ATPase and p-nitrophenylphosphatase from ... | [
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PMID:6312 | Drugs and brain mitochondrial enzymatic activities during post-natal development in rat. | The enzymatic activities of two mitochondrial enzymes, i.e. succinate dehydrogenase and NADH-cytochrome c reductase were investigated in the brain of rats at different stages of post-natal development. In addition, the effect of the pharmacological treatment with two drugs, nicergoline and bamethan, able to interact wi... | Drugs and brain mitochondrial enzymatic activities during post-natal development in rat. The enzymatic activities of two mitochondrial enzymes, i.e. succinate dehydrogenase and NADH-cytochrome c reductase were investigated in the brain of rats at different stages of post-natal development. In addition, the effect of th... | [
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PMID:6307 | [Comparative characteristics of fluorasizine metabolism in different species of animals and man]. | The process of phthoracizine (10-(beta-diethylaminopropiniol)-2-triphthormethylphenothiazine hydrochloride) transformation proceeding in various animal species and in man is similar in grosso modo to biotransformation of chlorpromazine and of compounds related to the latter, including sulphoxidation, dealkylation in th... | [Comparative characteristics of fluorasizine metabolism in different species of animals and man]. The process of phthoracizine (10-(beta-diethylaminopropiniol)-2-triphthormethylphenothiazine hydrochloride) transformation proceeding in various animal species and in man is similar in grosso modo to biotransformation of c... | [
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PMID:6309 | [Effect of analgestics and narcotics on the potentials of the posterior roots evoked by stimulation of the sensorimotor cortex]. | Experiments set up on unanesthetized, curarized cats demonstrated that sodium oxybutyrate in doses of 75--200 mg/kg and nembutal in doses of 5--20 mg/kg prolong the duration of corticospinal posterior roots potentials (PRP). The initial effect of morphine and promedol in doses of 1--3 and 0.5--1 mg/kg, respectively was... | [Effect of analgestics and narcotics on the potentials of the posterior roots evoked by stimulation of the sensorimotor cortex]. Experiments set up on unanesthetized, curarized cats demonstrated that sodium oxybutyrate in doses of 75--200 mg/kg and nembutal in doses of 5--20 mg/kg prolong the duration of corticospinal ... | [
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PMID:6310 | [Effect of narcotic analgesics on the cortical control process of impulse transmission in the afferent pathways of the sciatic nerve]. | The effect produced by narcotic analgetics with their intravenous administration on the process of cortical control over the transmission of impulses along specific routes of the sciatic nerve was studied. The conditioning stimulation of the cortex was effected by using a monopolar electrode through single electric imp... | [Effect of narcotic analgesics on the cortical control process of impulse transmission in the afferent pathways of the sciatic nerve]. The effect produced by narcotic analgetics with their intravenous administration on the process of cortical control over the transmission of impulses along specific routes of the sciati... | [
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PMID:6308 | [Effect of adrenergic compounds on the brain potentials evoked by stimulation of the dental pulp]. | Intraventriculare injections have brough evidence that alpha-adrenomimetic norepinephrine and beta-adrenomimetic isopropylnorepinephrine augment in the senso-motor region of the cortex the amplitude of primary responses evoked through a dental pulp stimulation. The alpha-adrenoblocking agents--dihydroergotoxin and phen... | [Effect of adrenergic compounds on the brain potentials evoked by stimulation of the dental pulp]. Intraventriculare injections have brough evidence that alpha-adrenomimetic norepinephrine and beta-adrenomimetic isopropylnorepinephrine augment in the senso-motor region of the cortex the amplitude of primary responses e... | [
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PMID:6311 | [Effect of izadrin, inderal and netalid on the periodic activity of the rabbit myometrium]. | The contractility of an isolated rabbit uterus was studied. It was found that when used in low concentrations (1.10(-9)-1.10(-7) g/ml) isoprenaline, while stimulating the beta-adrenoreceptors of the uterus, inhibits its contractions, whereas in high concentrations (1.10(6)-1.10(-5) g/ml) it is capable of intensifying u... | [Effect of izadrin, inderal and netalid on the periodic activity of the rabbit myometrium]. The contractility of an isolated rabbit uterus was studied. It was found that when used in low concentrations (1.10(-9)-1.10(-7) g/ml) isoprenaline, while stimulating the beta-adrenoreceptors of the uterus, inhibits its contract... | [
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PMID:6326 | Studies of human transcortin at different pHs: circular dichroism, polymerisation and binding affinity. | The transcortin we have used in this work is extremely pure. This was shown by the polymerisation observed at pH 4. This polymerisation is never observed with an impure form of transcortin [4]. Moreover, since it is known that the presence of cortisol in the binding site is an essential condition to the activity of pur... | Studies of human transcortin at different pHs: circular dichroism, polymerisation and binding affinity. The transcortin we have used in this work is extremely pure. This was shown by the polymerisation observed at pH 4. This polymerisation is never observed with an impure form of transcortin [4]. Moreover, since it is ... | [
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PMID:6340 | Cryptorchidism in the subfertile male. | Certain conclusions may be drawn from the present review and presentation of new data concerning the unilaterally cryptorchid patient and possible subfertility: 1. The truly undescended testis--not the retractile testis of infancy--will not descend spontaneously after 1 year of age. 2. The seminal quality of the unilat... | Cryptorchidism in the subfertile male. Certain conclusions may be drawn from the present review and presentation of new data concerning the unilaterally cryptorchid patient and possible subfertility: 1. The truly undescended testis--not the retractile testis of infancy--will not descend spontaneously after 1 year of ag... | [
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PMID:6342 | [Participation of the genetic apparatus in memory and learning phenomena]. | The first series of experiments showed that inhibition of the proteins synthesis followed by memory disorders, was reflected in decrease of the synaptosomal proteins fraction which was identified as the cholinoreceptor protein. Another series of experiments: training of rats to use unpreferred paw, showed the system ac... | [Participation of the genetic apparatus in memory and learning phenomena]. The first series of experiments showed that inhibition of the proteins synthesis followed by memory disorders, was reflected in decrease of the synaptosomal proteins fraction which was identified as the cholinoreceptor protein. Another series of... | [
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PMID:6343 | [Mechanisms of pial artery responses in hypo- and hypertension]. | Simultaneous study of the pial arterial responses and quantitative changes of the systemic arterial pressure, as well as of the PO2, pH and PCO2 on the brain surface, showed no correlation between the values and time of changes of the above parameters in rabbits. The vascular responses are concluded not to be caused by... | [Mechanisms of pial artery responses in hypo- and hypertension]. Simultaneous study of the pial arterial responses and quantitative changes of the systemic arterial pressure, as well as of the PO2, pH and PCO2 on the brain surface, showed no correlation between the values and time of changes of the above parameters in ... | [
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PMID:6345 | [The chronotropic effect of maximal stress on the heart and its regulation]. | The reflex bradycardia occurring at the maximal isometric heart strain produced by clamping of aorta was shown to be less intense if the heart rate prior to the experiment had been low. Vagotomy prevented or decreased the bradycardia. The beta-adrenoreceptor blockade with inderal significantly reduced the bradycardia, ... | [The chronotropic effect of maximal stress on the heart and its regulation]. The reflex bradycardia occurring at the maximal isometric heart strain produced by clamping of aorta was shown to be less intense if the heart rate prior to the experiment had been low. Vagotomy prevented or decreased the bradycardia. The beta... | [
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PMID:6346 | [The effect of atropine on acid formation in the stomach]. | In dogs, the effect of atropine on gastric acid secretion induced by food, mechanical stimuli, and histamine involved a complete block of the acid secretion but left the gastric secretory effect of histamine unaffected. Atropine caused about a twofold increase in duration of histamine-evoked acid secretion and a rise o... | [The effect of atropine on acid formation in the stomach]. In dogs, the effect of atropine on gastric acid secretion induced by food, mechanical stimuli, and histamine involved a complete block of the acid secretion but left the gastric secretory effect of histamine unaffected. Atropine caused about a twofold increase ... | [
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PMID:6347 | Influence of the properties of skin allografts on the "graft survival promoting effect" of antilymphocyte serum. | Changes in the properties of non-H-2 imcompatible skin allografts, resulting from treating the graft donors with whole-body irradiation, antilymphocyte serum, cyclophosphamide, hydrocortisone, amethopterin and azathioprine, affected differently their survival in the recipients pretreated with normal and antilymphocyte ... | Influence of the properties of skin allografts on the "graft survival promoting effect" of antilymphocyte serum. Changes in the properties of non-H-2 imcompatible skin allografts, resulting from treating the graft donors with whole-body irradiation, antilymphocyte serum, cyclophosphamide, hydrocortisone, amethopterin a... | [
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PMID:6359 | The effect of cimetidine, a new histamine H2-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer. | Meal-stimulated acid secretion, measured by in vivo intragastric titration, was progressively inhibited by increasing oral doses of cimetidine (25 to 400 mg). Four hundred milligrams suppressed acid secretion by 73% for the first 3 hr after the meal, whereas it inhibited acid secretion by 94% during the 30-min period o... | The effect of cimetidine, a new histamine H2-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer. Meal-stimulated acid secretion, measured by in vivo intragastric titration, was progressively inhibited by increasing oral doses of cimetidine (25 to ... | [
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PMID:6360 | Role of fat maldigestion in pathogenesis of steatorrhea in ileal resection. Fat digestion after two sequential test meals with and without cholestyramine. | To clarify the role of fat maldigestion in the pathogenesis of steatorrhea in patients with ileal resection the total and aqueous phase concentrations of bile acid and fatty acid were characterized in 8 such patients (5 patients with small ileal resection, bile acid diarrhea, and steatorrhea less than 20 g per day; 3 p... | Role of fat maldigestion in pathogenesis of steatorrhea in ileal resection. Fat digestion after two sequential test meals with and without cholestyramine. To clarify the role of fat maldigestion in the pathogenesis of steatorrhea in patients with ileal resection the total and aqueous phase concentrations of bile acid a... | [
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PMID:6361 | Evaluation of esophageal tests in the diagnosis of reflux esophagitis. | The sensitivity and specificity of each of five esophageal tests used in the diagnosis of reflux esophagitis were compared with those of six combinations of two tests, one indicating esophagitis and the other indicating sphincter incompetence. The esophageal tests were performed in patients with reflux symptoms, chest ... | Evaluation of esophageal tests in the diagnosis of reflux esophagitis. The sensitivity and specificity of each of five esophageal tests used in the diagnosis of reflux esophagitis were compared with those of six combinations of two tests, one indicating esophagitis and the other indicating sphincter incompetence. The e... | [
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PMID:6362 | [Investigations on the distribution, cause and prevention of early perinatal morbidity (author's transl)]. | These investigations were designed to detect causes of early perinatal morbidity in order to develop methods to decrease the perinatal morbidity in our unit. From October 1972 to December 1974 the most important antenatal, intrapartum and postpartum data on 2210 deliveries were coded. In 98% of the cases continuous fet... | [Investigations on the distribution, cause and prevention of early perinatal morbidity (author's transl)]. These investigations were designed to detect causes of early perinatal morbidity in order to develop methods to decrease the perinatal morbidity in our unit. From October 1972 to December 1974 the most important a... | [
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PMID:6372 | Sugar and amino acid transport in animal cells. | The molecular basis of intracellular metabolism of nutrients and its control is quite well understood in animal cells. Comparable knowledge about solute entry into cells is still lacking, as, in contrast to metabolism, no chemical reactions seem to be directly associated with the known nutrient transport. Nevertheless,... | Sugar and amino acid transport in animal cells. The molecular basis of intracellular metabolism of nutrients and its control is quite well understood in animal cells. Comparable knowledge about solute entry into cells is still lacking, as, in contrast to metabolism, no chemical reactions seem to be directly associated ... | [
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PMID:6391 | Diethylaminoethyl-cellulose-bacterial cell immunoadsorbent columns: preparation of serotype-specific globulin and immunofluorescent conjugates for Streptococcus mutans serotypes a and d. | Diethylaminoethyl (DEAE)-cellulose was used as a support material for preparing bacterial cell columns. Pretreatment of the bacterial cells with formalin was essential in obtaining satisfactory adherence of the cells to DEAE-cellulose. Cross-reacting antibodies were removed from antibody preparations against strains of... | Diethylaminoethyl-cellulose-bacterial cell immunoadsorbent columns: preparation of serotype-specific globulin and immunofluorescent conjugates for Streptococcus mutans serotypes a and d. Diethylaminoethyl (DEAE)-cellulose was used as a support material for preparing bacterial cell columns. Pretreatment of the bacterial... | [
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PMID:6394 | Kinetic studies of the alkaline mesentericopeptidase. Study on the active centre topography of alkaline mesentericopeptidase by means of bifunctional reversible inhibition. | The inhibitory effect of alkylboronic acids H(CH2)nB(OH)2(n=2-8) and Ph(CH2)n-B(OH)2, (n=0-4), on the alkaline mesentericopeptidase-catalysed hydrolysis of synthetic substrates was studied. It was shown that alkylboronic acids act as bifunctional reversible inhibitors. The borate group interacts with an ionogenic group... | Kinetic studies of the alkaline mesentericopeptidase. Study on the active centre topography of alkaline mesentericopeptidase by means of bifunctional reversible inhibition. The inhibitory effect of alkylboronic acids H(CH2)nB(OH)2(n=2-8) and Ph(CH2)n-B(OH)2, (n=0-4), on the alkaline mesentericopeptidase-catalysed hydro... | [
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PMID:6395 | Unusual behaviour of a protein: reversible quantitative precipitation of staphylococcal delta-haemolysin by low concentrations of some organic solvents. | Staphylococcal delta-haemolysin is precipitated from watery solutions by low concentrations of chloroform. The effect on this precipitation of pH, kind and concentration of salts, and concentration of, and time of exposure to, chloroform have been investigated. Some but not all of the other solvents tested cause a simi... | Unusual behaviour of a protein: reversible quantitative precipitation of staphylococcal delta-haemolysin by low concentrations of some organic solvents. Staphylococcal delta-haemolysin is precipitated from watery solutions by low concentrations of chloroform. The effect on this precipitation of pH, kind and concentrati... | [
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PMID:6396 | Deamidated active intermediates in the irreversible acid denaturation of ribonuclease-A. | A study has been made on the changes in the enzymatic activity of Ribonuclease-A**-(RNase-A) exposed to highly acidic (pH less than 1) acqueous environment. Irreversible alterations of activity were observed when the protein was exposed to an acidic medium for a long period (20 to 60 h). Even prior to these changes in ... | Deamidated active intermediates in the irreversible acid denaturation of ribonuclease-A. A study has been made on the changes in the enzymatic activity of Ribonuclease-A**-(RNase-A) exposed to highly acidic (pH less than 1) acqueous environment. Irreversible alterations of activity were observed when the protein was ex... | [
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PMID:6397 | Covalent coupling of bilirubin to albumin. | A method for covalent coupling of bilirubin to albumin is described. Human serum albumin-bilirubin (1:1 complex) has been treated with water soluble carbodiimide in order to obtain covalent coupling of bilirubin to albumin. The reaction conditions have been varied with respect to pH, reaction time and concentration of ... | Covalent coupling of bilirubin to albumin. A method for covalent coupling of bilirubin to albumin is described. Human serum albumin-bilirubin (1:1 complex) has been treated with water soluble carbodiimide in order to obtain covalent coupling of bilirubin to albumin. The reaction conditions have been varied with respect... | [
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PMID:6398 | Inactivation of trypsin and chymotrypsin with a photosensitive probe. | The photosensitive inactivation of trypsin and chymotrypsin by 4-fluoro-3-nitrophenyl azide (FNPA) is described. A dark inhibition was observed at elevated probe concentrations, and was reversible. The enzymes were stable to photolysis in the absence of probe. Photolytic inactivation of trypsin and chymotrypsin with FN... | Inactivation of trypsin and chymotrypsin with a photosensitive probe. The photosensitive inactivation of trypsin and chymotrypsin by 4-fluoro-3-nitrophenyl azide (FNPA) is described. A dark inhibition was observed at elevated probe concentrations, and was reversible. The enzymes were stable to photolysis in the absence... | [
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PMID:6401 | Pathways of the eye's response to topical nitrogen mustard. | We studied the effect of prior corneal herpes simplex infection with its resultant corneal hypesthesia on the irritative response of the rabbit eye to topical nitrogen mustard. Both the miosis and the breakdown of the blood-aqueous barrier that follow the application of topical nitrogen mustard were diminished in eyes ... | Pathways of the eye's response to topical nitrogen mustard. We studied the effect of prior corneal herpes simplex infection with its resultant corneal hypesthesia on the irritative response of the rabbit eye to topical nitrogen mustard. Both the miosis and the breakdown of the blood-aqueous barrier that follow the appl... | [
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PMID:6402 | Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. | Timolol ophthalmic solutions 0.5 per cent, 1.0 per cent, and 1.5 per cent lowered intraocular pressures significantly in normal human volunteers. Maximum lowering of the intraocular pressures was reached at two hours with the 0.5 per cent solution of timolol and at one hour with the 1.0 per cent and 1.5 per cent timolo... | Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. Timolol ophthalmic solutions 0.5 per cent, 1.0 per cent, and 1.5 per cent lowered intraocular pressures significantly in normal human volunteers. Maximum lowering of the intraocular pressures was reached at two hours with the 0.5 ... | [
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PMID:6403 | The adrenergic receptors of the intraocular muscles of the human eye. | The adrenergic receptors in man were analyzed using isolated sphincter, dilator, and ciliary muscle strips, dissected from eyebank eyes. The dilator is mainly alpha, the sphincter both alpha and beta, and the ciliary muscle predominantly beta adrenergic. | The adrenergic receptors of the intraocular muscles of the human eye. The adrenergic receptors in man were analyzed using isolated sphincter, dilator, and ciliary muscle strips, dissected from eyebank eyes. The dilator is mainly alpha, the sphincter both alpha and beta, and the ciliary muscle predominantly beta adrener... | [
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PMID:6404 | pH-dependent temperature sensitivity of rat lens phosphofructokinase. | Rat lens phosphofructokinase (PFK) has been found to be cold-labile at acidic pH, even in the presence of sulfate and inorganic phosphate, two known positive effectors. The inactivation appears to be an irreversible process, but can be prevented by including ATP in the incubating media. The enzyme is relatively stable ... | pH-dependent temperature sensitivity of rat lens phosphofructokinase. Rat lens phosphofructokinase (PFK) has been found to be cold-labile at acidic pH, even in the presence of sulfate and inorganic phosphate, two known positive effectors. The inactivation appears to be an irreversible process, but can be prevented by i... | [
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PMID:6405 | The fetal renin-angiotensin system in normal and hypertensive pregnancy. | Plasma angiotensin II was measured in the umbilical cord arterial and/or venous blood of 54 babies delivered vaginally and in 12 delivered by elective lower segment cesarean section. Angiotensin II was also measured in the peripheral venous blood of 51 of the mothers. Mean angiotensin II levels at delivery were higher ... | The fetal renin-angiotensin system in normal and hypertensive pregnancy. Plasma angiotensin II was measured in the umbilical cord arterial and/or venous blood of 54 babies delivered vaginally and in 12 delivered by elective lower segment cesarean section. Angiotensin II was also measured in the peripheral venous blood ... | [
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PMID:6406 | Use of salazopyrin for prevention of peritoneal adhesions in rats. | The effect of orally administered salazopyrin on the prevention of experimentally induced peritoneal adhesions in albino rats was investigated. Comparison of the findings with those for untreated rats and rats given penicillin for sulfadiazine indicated that salazopyrin has a preventive effect on the development of per... | Use of salazopyrin for prevention of peritoneal adhesions in rats. The effect of orally administered salazopyrin on the prevention of experimentally induced peritoneal adhesions in albino rats was investigated. Comparison of the findings with those for untreated rats and rats given penicillin for sulfadiazine indicated... | [
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PMID:6407 | [Optimal dosage in peroral therapy of acne with vitamin A palmitate]. | Successful oral therapy with vitamin A palmitate in acne vulgaris requires 150,000-200,000 I.U. daily for months. Side-effects were evaluated in 22 patients and in addition in 54 patients receiving 400,000 and 300,000 I.U. respectively for 3-4 weeks (SGPT, GGPT, Quick, electrophoresis, creatinine, bromosulfthaleine exc... | [Optimal dosage in peroral therapy of acne with vitamin A palmitate]. Successful oral therapy with vitamin A palmitate in acne vulgaris requires 150,000-200,000 I.U. daily for months. Side-effects were evaluated in 22 patients and in addition in 54 patients receiving 400,000 and 300,000 I.U. respectively for 3-4 weeks ... | [
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PMID:6410 | Chemical modification of streptovaricin C I. 19-O-substituted damavaricin C. | Damavaricin C, a degradative derivative of streptovaricin C, has reduced antibiotic activity relative to streptovaricin C. It has, however, a new phenolic hydroxyl group at the C-19 position of the naphthoquinone ring on which various groups can be substituted through an ether linkage. A series of 19-O-substituted deri... | Chemical modification of streptovaricin C I. 19-O-substituted damavaricin C. Damavaricin C, a degradative derivative of streptovaricin C, has reduced antibiotic activity relative to streptovaricin C. It has, however, a new phenolic hydroxyl group at the C-19 position of the naphthoquinone ring on which various groups c... | [
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PMID:6411 | Comparative in vitro activity of cephalosporins. | The in vitro activity of cephalexin, cephaloridine, cephalothin, cephapirin, cefoxitin, cephamycin C, cepharadine and cefazolin was determined against 443 isolates of bacteria. At a concentration of 12.5 mug/ml, all of the cephalosporins inhibited more than 60% of the isolates of Klebsiella pneumoniae. At the same conc... | Comparative in vitro activity of cephalosporins. The in vitro activity of cephalexin, cephaloridine, cephalothin, cephapirin, cefoxitin, cephamycin C, cepharadine and cefazolin was determined against 443 isolates of bacteria. At a concentration of 12.5 mug/ml, all of the cephalosporins inhibited more than 60% of the is... | [
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PMID:6417 | Oxygen dissociation curve for chorioallantoic capillary blood of chicken embryo. | Oxygen dissociation curves for blood in the chorioallantoic capillary of chicken embryos were determined using a microphotometric apparatus made for measuring the reaction velocity of a red blood cell with oxygen and carbon monoxide. The modified Hill's equations expressing the dissociation curve during development wer... | Oxygen dissociation curve for chorioallantoic capillary blood of chicken embryo. Oxygen dissociation curves for blood in the chorioallantoic capillary of chicken embryos were determined using a microphotometric apparatus made for measuring the reaction velocity of a red blood cell with oxygen and carbon monoxide. The m... | [
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PMID:6418 | Failure of histamine antagonists to prevent hypoxic pulmonary vasoconstriction in dogs. | The role of histamine as a mediator of hypoxic pulmonary vasoconstriction was examined in intact anesthetized dogs. Antagonism of histamine vasoconstrictor (H1) receptors with a classic antihistaminic drug (chlorpheniramine) failed to prevent or modify the pulmonary vascular responses to hypoxia (10% O2). Blockade of h... | Failure of histamine antagonists to prevent hypoxic pulmonary vasoconstriction in dogs. The role of histamine as a mediator of hypoxic pulmonary vasoconstriction was examined in intact anesthetized dogs. Antagonism of histamine vasoconstrictor (H1) receptors with a classic antihistaminic drug (chlorpheniramine) failed ... | [
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PMID:6419 | Circulatory effects of prolonged hypoxia before and during antihistamine. | Five chronically instrumented healthy dogs were exposed to a 5-day period of breathing 10% oxygen in a chamber. The response to hypoxia was found to be time dependent. During the first 24 h of hypoxia the circulatory response was characterized by increases in cardiac output, heart rate, pulmonary and systemic arterial ... | Circulatory effects of prolonged hypoxia before and during antihistamine. Five chronically instrumented healthy dogs were exposed to a 5-day period of breathing 10% oxygen in a chamber. The response to hypoxia was found to be time dependent. During the first 24 h of hypoxia the circulatory response was characterized by... | [
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PMID:6420 | Dual contribution theory of regulation of CSF HCO3 in respiratory acidosis. | Regulation of CSF HCO3-in respiratory acidosis was studied in light of the "dual contribution theory," which proposed that there were two sources for the CSF HCO3-increase: 1) HCO3-by diffusion from plasma and 2) HCO3-generated in the CNS and catalyzed by the local carbonic anhydrase (J. Appl. Physiol. 38: 504-512, 197... | Dual contribution theory of regulation of CSF HCO3 in respiratory acidosis. Regulation of CSF HCO3-in respiratory acidosis was studied in light of the "dual contribution theory," which proposed that there were two sources for the CSF HCO3-increase: 1) HCO3-by diffusion from plasma and 2) HCO3-generated in the CNS and c... | [
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PMID:6421 | Effects of continuous positive-pressure ventilation in experimental pulmonary edema. | We compared the effects of continuous positive-pressure ventilation (CPPV), using 10 cmH2O positive end-expiratory pressure (PEEP), with intermittent positive-pressure ventilation (IPPV), on pulmonary extravascular water volume (PEWV) and lung function in dogs with pulmonary edema caused by elevated left atrial pressur... | Effects of continuous positive-pressure ventilation in experimental pulmonary edema. We compared the effects of continuous positive-pressure ventilation (CPPV), using 10 cmH2O positive end-expiratory pressure (PEEP), with intermittent positive-pressure ventilation (IPPV), on pulmonary extravascular water volume (PEWV) ... | [
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PMID:6422 | Evaluation of a dual-function pH and PCO2 in vivo sensor. | A newly developed, dual-function pH and PCO2 sensor was evaluated in this study. The sensors were placed in the femoral arteries of dogs anesthetized with sodium pentobarbital. Comparisons were made between systemic arterial pH and PCO2 measured using the sensor and those measured from blood samples drawn at 15-min int... | Evaluation of a dual-function pH and PCO2 in vivo sensor. A newly developed, dual-function pH and PCO2 sensor was evaluated in this study. The sensors were placed in the femoral arteries of dogs anesthetized with sodium pentobarbital. Comparisons were made between systemic arterial pH and PCO2 measured using the sensor... | [
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PMID:6423 | Polymer membrane sensors for continuous intravascular monitoring of blood pH. | A new type of pH sensor suitable for chronic intra-vascular implantation by virtue of its small size, flexibility, and ruggedness was constructed and evaluated. The pH-sensitive element was a thin film of an elastromeric polymer made ion permselective to proteons by adding a lipophilic, specific H+-ion carrier. This wa... | Polymer membrane sensors for continuous intravascular monitoring of blood pH. A new type of pH sensor suitable for chronic intra-vascular implantation by virtue of its small size, flexibility, and ruggedness was constructed and evaluated. The pH-sensitive element was a thin film of an elastromeric polymer made ion perm... | [
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PMID:6424 | Temperature-induced changes in blood acid-base status: pH and PCO2 in a binary buffer. | Equations for proton equilibria of a single-phase binary buffer system have been applied to temperature-induced changes in pH and PCO2 of separated dog plasma at constant carbon dioxide content. Predicted behaviour, measured as deltapH/deltaT and deltalog PCO2 /deltaT, and pH and PCO2 as a function of temperature (rang... | Temperature-induced changes in blood acid-base status: pH and PCO2 in a binary buffer. Equations for proton equilibria of a single-phase binary buffer system have been applied to temperature-induced changes in pH and PCO2 of separated dog plasma at constant carbon dioxide content. Predicted behaviour, measured as delta... | [
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PMID:6425 | Temperature-induced changes in blood acid-base status: Donnan rCl and red cell volume. | The Donnan ratio for chloride ion (rCl) was determined for human red cells in plasma utilizing 36Cl. The effect of altered PCO2 and pH on rCl was followed in two ways. CO2 partial pressure was varied (1-1.5% CO2 in O2; pH range 7.1-7.9) at 37.5 degrees C (isothermal); PCO2 and pH were also changed by altering temperatu... | Temperature-induced changes in blood acid-base status: Donnan rCl and red cell volume. The Donnan ratio for chloride ion (rCl) was determined for human red cells in plasma utilizing 36Cl. The effect of altered PCO2 and pH on rCl was followed in two ways. CO2 partial pressure was varied (1-1.5% CO2 in O2; pH range 7.1-7... | [
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PMID:6427 | Influence of pH on the rate of ribosomal ribonucleic acid synthesis during sporulation in Saccharomyces cerevisiae. | The rate of synthesis of ribosomal RNA (rRNA) is much slower during sporulation than during vegetative growth of yeast. If sporulating cells are transferred from normal incubation conditions at pH 8.8 to the same medium adjusted to pH 7.0, the rate of rRNA synthesis increased to approach that observed in vegetative cel... | Influence of pH on the rate of ribosomal ribonucleic acid synthesis during sporulation in Saccharomyces cerevisiae. The rate of synthesis of ribosomal RNA (rRNA) is much slower during sporulation than during vegetative growth of yeast. If sporulating cells are transferred from normal incubation conditions at pH 8.8 to ... | [
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PMID:6426 | Regulation of histidase synthesis in intergeneric hybrids of enteric bacteria. | Regulation of the expression of the histidase coded by hutk of Klebsiella aerogenes in Salmonella typhimurium and in Escherichia coli and of the expression of the histidase coded by huts of S. typhimurium in E. coli was investigated. The hutk histidase was found to be sensitive to catabolite repression in K. aerogenes ... | Regulation of histidase synthesis in intergeneric hybrids of enteric bacteria. Regulation of the expression of the histidase coded by hutk of Klebsiella aerogenes in Salmonella typhimurium and in Escherichia coli and of the expression of the histidase coded by huts of S. typhimurium in E. coli was investigated. The hut... | [
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PMID:6428 | Role of polyadenylic acid in a deoxyribonucleic acid-membrane fraction extracted from pneumococci. | After the addition of radioactive polyadenylic acid to cell suspensions of pneumocci, part of the radioactivity becomes associated with a deoxyribonucleic acid (DNA)-membrane fraction extracted from the cells. A variety of techniques show that a portion of this associated radioactivity may represent oligoadenylates com... | Role of polyadenylic acid in a deoxyribonucleic acid-membrane fraction extracted from pneumococci. After the addition of radioactive polyadenylic acid to cell suspensions of pneumocci, part of the radioactivity becomes associated with a deoxyribonucleic acid (DNA)-membrane fraction extracted from the cells. A variety o... | [
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PMID:6429 | Glutamate dehydrogenase: genetic mapping and isolation of regulatory mutants of Klebsiella aerogenes. | The gene for glutamate dehydrogenase (gdhD) has been mapped in Klebsiella aerogenes by P1 transduction. It is linked to pyrF and trp with the order pyrF-trp-gdh. Complementation analysis using F' episomes from Escherichia coli suggests an analogous location in E. coli. Two mutants able to produce glutamate dehydrogenas... | Glutamate dehydrogenase: genetic mapping and isolation of regulatory mutants of Klebsiella aerogenes. The gene for glutamate dehydrogenase (gdhD) has been mapped in Klebsiella aerogenes by P1 transduction. It is linked to pyrF and trp with the order pyrF-trp-gdh. Complementation analysis using F' episomes from Escheric... | [
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PMID:6430 | Adenosine 5'-triphosphate synthesis energized by an artificially imposed membrane potential in membrane vesicles of Escherichia coli. | Adenosine 5'-triphosphate (ATP) synthesis driven by an artificially imposed membrane potential in right-side-out membrane vesicles of Escherichia coli was investigated. Membrane vesicles prepared in the presence of adenosine diphosphate were loaded with K+ by incubation with 0.5 M potassium phosphate. Addition of valin... | Adenosine 5'-triphosphate synthesis energized by an artificially imposed membrane potential in membrane vesicles of Escherichia coli. Adenosine 5'-triphosphate (ATP) synthesis driven by an artificially imposed membrane potential in right-side-out membrane vesicles of Escherichia coli was investigated. Membrane vesicles... | [
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PMID:6431 | Regulation of enzyme formation in Klebsiella aerogenes by episomal glutamine synthetase of Escherichia coli. | We studied the physiology of cells of Klebsiella aerogenes containing the structural gene for glutamine synthetase (glnA) of Escherichia coli on an episome. The E. coli glutamine synthetase functioned in cells of K. aerogenes in a manner similar to that of the K. aerogenes enzyme: it allowed the level of histidase to i... | Regulation of enzyme formation in Klebsiella aerogenes by episomal glutamine synthetase of Escherichia coli. We studied the physiology of cells of Klebsiella aerogenes containing the structural gene for glutamine synthetase (glnA) of Escherichia coli on an episome. The E. coli glutamine synthetase functioned in cells o... | [
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PMID:6432 | Kinetic properties of Serratia marcescens adenosine 5'-diphosphate glucose pyrophosphorylase. | The regulatory properties of partially purified adenosine 5'-diphosphate-(ADP) glucose pyrophosphorylase from two Serratia marcescens strains (ATCC 274 and ATCC 15365) have been studied. Slight or negligible activation by fructose-P2, pyridoxal-phosphate, or reduced nicotinamide adenine dinucleotide phosphate (NADPH) w... | Kinetic properties of Serratia marcescens adenosine 5'-diphosphate glucose pyrophosphorylase. The regulatory properties of partially purified adenosine 5'-diphosphate-(ADP) glucose pyrophosphorylase from two Serratia marcescens strains (ATCC 274 and ATCC 15365) have been studied. Slight or negligible activation by fruc... | [
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PMID:6433 | Characterization of group B colicin-resistant mutants of Escherichia coli K-12: colicin resistance and the role of enterochelin. | Nine classes of group B colicin-resistant mutants were examined to study the role of enterochelin in colicin resistance. Four of the mutants studied (cbt, exbC, exbB, and tonB) hypersecreted enterochelin. Enterochelin hypersecretion was apparently responsible for resistance of the exbC mutant to colicins G and H and fo... | Characterization of group B colicin-resistant mutants of Escherichia coli K-12: colicin resistance and the role of enterochelin. Nine classes of group B colicin-resistant mutants were examined to study the role of enterochelin in colicin resistance. Four of the mutants studied (cbt, exbC, exbB, and tonB) hypersecreted ... | [
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PMID:6434 | Metabolism of the reserve polysaccharide of Streptococcus mitior (mitis): is there a second alpha-1,4-glucan phosphorylase? | The alpha-1,4-glucan phosphorylase (alpha-1,4-glucan: orthophosphate glucosyltransferase; EC 2.4.1.1) associated with the particulate cell fraction of Streptococcus mitior strain S3 was compared with the soluble maltodextrin phosphorylase that had been previously isolated from the same organism (Walker et al., 1969). T... | Metabolism of the reserve polysaccharide of Streptococcus mitior (mitis): is there a second alpha-1,4-glucan phosphorylase? The alpha-1,4-glucan phosphorylase (alpha-1,4-glucan: orthophosphate glucosyltransferase; EC 2.4.1.1) associated with the particulate cell fraction of Streptococcus mitior strain S3 was compared w... | [
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PMID:6435 | Polygalacturonic acid trans-eliminase in the osmotic shock fluid of Erwinia rubrifaciens: characterization of the purified enzyme and its effect on plant cells. | An endopolygalacturonic acid trans-eliminase (EC 4.2.2.2), released by osmotic shock of Erwinia rubrifaciens cells, has been purified to near homogeneity (3, 100-fold) by column chromatography on diethylaminoethyl-cellulose, phosphocellulose, and hydroxyapatite-cellulose followed by isoelectric focusing. It has a molec... | Polygalacturonic acid trans-eliminase in the osmotic shock fluid of Erwinia rubrifaciens: characterization of the purified enzyme and its effect on plant cells. An endopolygalacturonic acid trans-eliminase (EC 4.2.2.2), released by osmotic shock of Erwinia rubrifaciens cells, has been purified to near homogeneity (3, 1... | [
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PMID:6436 | Purification of several bacteriolytic enzymes by affinity chromatography on lysozyme-lysate of Micrococcus lysodeikticus cell wall coupled with sepharose. | Using lysozyme-lysate of Micrococcus lysodeikticus cell wall coupled with Sepharose, several bacteriolytic enzymes were purified from crude preparations of animal and microbial origin. Quail egg-white, human milk and salivary lysozymes [EC 3.2.1.17] were adsorbed onto the adsorbent at pH 5-7 and eluted with 2M NaCl at ... | Purification of several bacteriolytic enzymes by affinity chromatography on lysozyme-lysate of Micrococcus lysodeikticus cell wall coupled with sepharose. Using lysozyme-lysate of Micrococcus lysodeikticus cell wall coupled with Sepharose, several bacteriolytic enzymes were purified from crude preparations of animal an... | [
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PMID:6437 | Enzymatic studies on a cellulase system of Trichoderma viride. III. Transglycosylation properties of two cellulase components of random type. | Two highly purified cellulases [EC 3.2.1.4], II-A, and II-B, were obtained from the cellulase system of Trichoderma viride. Both cellulases split cellopentaose retaining the beta-configuration of the anomeric carbon atoms in the hydrolysis products at both pH 3.5 and 5.0. The Km values of cellulases II-A and II-B for c... | Enzymatic studies on a cellulase system of Trichoderma viride. III. Transglycosylation properties of two cellulase components of random type. Two highly purified cellulases [EC 3.2.1.4], II-A, and II-B, were obtained from the cellulase system of Trichoderma viride. Both cellulases split cellopentaose retaining the beta... | [
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PMID:6438 | Binding of N-acetyl-chitotriose to human lysozyme. | The interaction of N-acetyl-chitotriose ((GlcNAc)3) with human lysozyme [EC 3.2.1.17] was studied at various pH values by measuring changes in the circular dichroic (CD) band at 294 or 255 nm and the data were compared with the results for hen and turkey lysozymes reported previously (Kuramitsu et al. (1974) J. Biochem... | Binding of N-acetyl-chitotriose to human lysozyme. The interaction of N-acetyl-chitotriose ((GlcNAc)3) with human lysozyme [EC 3.2.1.17] was studied at various pH values by measuring changes in the circular dichroic (CD) band at 294 or 255 nm and the data were compared with the results for hen and turkey lysozymes repo... | [
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PMID:6439 | Kinetics and equilibrium studies on autologous and heterologous recombinations of heavy and light chains of myeloma proteins. | 1. The kinetics of the heterologous recombination reaction of alkylated H chains of a myeloma protein (Jo) with alkylated L chains of another myeloma protein (Ita) were studied by following changes with time in the circular dichroism at 235 nm and the results were compared with those for the autologous recombination of... | Kinetics and equilibrium studies on autologous and heterologous recombinations of heavy and light chains of myeloma proteins. 1. The kinetics of the heterologous recombination reaction of alkylated H chains of a myeloma protein (Jo) with alkylated L chains of another myeloma protein (Ita) were studied by following chan... | [
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PMID:6440 | Studies on phospholipases from Streptomyces. II. Purification and properties of Streptomyces hachijoensis phospholipase D. | 1. Phospholipase D [EC 3.1.4.4] from Streptomyces hachijoensis was purified about 570-fold by column chromatography on DEAE-cellulose and Sephadex G-50 followed by isoelectric focusing. 2. The purified preparation was found to be homogeneous both by immunodiffusion and polyacrylamide disc gel electrophoresis. 3. The is... | Studies on phospholipases from Streptomyces. II. Purification and properties of Streptomyces hachijoensis phospholipase D. 1. Phospholipase D [EC 3.1.4.4] from Streptomyces hachijoensis was purified about 570-fold by column chromatography on DEAE-cellulose and Sephadex G-50 followed by isoelectric focusing. 2. The puri... | [
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PMID:6441 | Pyridine-2, 6-dicarboxylic acid (dipicolinic acid) formation in Bacillus subtilis. II Non-enzymatic and enzymatic formations of dipicolinic acid from alpha, epsilon-diketopimelic acid and ammonia. | Non-enzymatic formation of dipicolinic acid (DPA) from diketopimelic acid and ammonia was clearly demonstrated using a new method for DPA analysis. The reaction rates of DPA formation were almost the same under aerobic and anaerobic conditions. Nearly equimolecular quantities of DPA and tetrahydrodipicolinic acid were ... | Pyridine-2, 6-dicarboxylic acid (dipicolinic acid) formation in Bacillus subtilis. II Non-enzymatic and enzymatic formations of dipicolinic acid from alpha, epsilon-diketopimelic acid and ammonia. Non-enzymatic formation of dipicolinic acid (DPA) from diketopimelic acid and ammonia was clearly demonstrated using a new ... | [
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PMID:6442 | Trinitrophenylation of nucleic acids and their constituents. | 1. Under relatively mild conditions, nucleic acids and their constituents were trinitrophenylated with 2,4,6-trinitrobenzenesulfonate (TNBS) in aqueous solution (pH 8-11), yielding reddish-orange trinitrophenyl (TNP) derivatives. Guanine residues were trinitrophenylated on the base residues at the 2-amino group (N2-TNP... | Trinitrophenylation of nucleic acids and their constituents. 1. Under relatively mild conditions, nucleic acids and their constituents were trinitrophenylated with 2,4,6-trinitrobenzenesulfonate (TNBS) in aqueous solution (pH 8-11), yielding reddish-orange trinitrophenyl (TNP) derivatives. Guanine residues were trinitr... | [
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PMID:6445 | Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. | The guanosine 3',5'-cyclic monophosphate (cGMP) level in the mouse splenic lymphocytes was increased about 2- to 3-fold by concanavalin A. This increase was completely dependent on the presence of Ca2+ in the medium. Homogenates of mouse splenic lymphocytes contained significant guanylate cyclase [EC 4.6.1.2] activity ... | Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. The guanosine 3',5'-cyclic monophosphate (cGMP) level in the mouse splenic lymphocytes was increased about 2- to 3-fold by concanavalin A. This increase was completely dependent on the presence of Ca2+ in the medium. Homogenates of mouse splenic l... | [
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PMID:6446 | Rat intestinal brush border membrane peptidases. II. Enzymatic properties, immunochemistry, and interactions with lectins of two different forms of the enzyme. | The properties of two purified peptidases derived from the intestinal brush border membrane of the rat have been investigated. The pH optima, heat stabilities, substrate specificities, and metal ion requirements of the two enzymes and the effects of inhibitors on their activities were nearly identical. The isoenzymes c... | Rat intestinal brush border membrane peptidases. II. Enzymatic properties, immunochemistry, and interactions with lectins of two different forms of the enzyme. The properties of two purified peptidases derived from the intestinal brush border membrane of the rat have been investigated. The pH optima, heat stabilities, ... | [
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PMID:6447 | Transport of riboflavin into yeast cells. | Riboflavin-requiring mutants of Saccharomyces cerevisiae are able to transport 14C-labeled riboflavin into the cell, although no significant transport is seen in commercial yeast or in the parent strain from which the mutants were derived. Transport activity is greatest in the early to mid-log phase of anaerobic growth... | Transport of riboflavin into yeast cells. Riboflavin-requiring mutants of Saccharomyces cerevisiae are able to transport 14C-labeled riboflavin into the cell, although no significant transport is seen in commercial yeast or in the parent strain from which the mutants were derived. Transport activity is greatest in the ... | [
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PMID:6448 | Soluble enzyme system for vitamin K-dependent carboxylation. | The vitamin K-dependent carboxylating system has been solubilized by Lubrol PX or Triton X-100 treatment of vitamin K-deficient rat liver microsomes. As obtained from vitamin K-deficient rat liver, this soluble preparation is dependent upon the in vitro addition of vitamin K1 for carboxylating activity. The enzyme syst... | Soluble enzyme system for vitamin K-dependent carboxylation. The vitamin K-dependent carboxylating system has been solubilized by Lubrol PX or Triton X-100 treatment of vitamin K-deficient rat liver microsomes. As obtained from vitamin K-deficient rat liver, this soluble preparation is dependent upon the in vitro addit... | [
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PMID:6449 | Glutamate synthase. Properties of the glutamine-dependent activity. | Properties of glutamine-dependent glutamate synthase have been investigated using homogeneous enzyme from Escherichia coli K-12. In contrast to results with enzyme from E. coli strain B (Miller, R. E., and Stadtman, E. R. (1972) J. Biol. Chem. 247, 7407-7419), this enzyme catalyzes NH3-dependent glutamate synthase acti... | Glutamate synthase. Properties of the glutamine-dependent activity. Properties of glutamine-dependent glutamate synthase have been investigated using homogeneous enzyme from Escherichia coli K-12. In contrast to results with enzyme from E. coli strain B (Miller, R. E., and Stadtman, E. R. (1972) J. Biol. Chem. 247, 740... | [
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PMID:6450 | Properties of apoglutamate synthase and comparison with glutamate dehydrogenase. | Glutamate synthase from Escherichia coli K-12 exhibits NH3-dependent activity. NH3-dependent activity is increased approximately 5-fold in apoglutamate synthase lacking flavin and non-heme iron. Whereas glutamine plus 2-oxoglutarate have the capacity to reoxidize the chemically reduced flavoenzyme, no such reoxidation ... | Properties of apoglutamate synthase and comparison with glutamate dehydrogenase. Glutamate synthase from Escherichia coli K-12 exhibits NH3-dependent activity. NH3-dependent activity is increased approximately 5-fold in apoglutamate synthase lacking flavin and non-heme iron. Whereas glutamine plus 2-oxoglutarate have t... | [
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PMID:6451 | Mechanism of the irreversible inhibition of aspartate aminotransferase by the bacterial toxin L-2-amino-4-methoxy-trans-3-butenoic acid. | The naturally occurring toxin L-2-amino-4-methoxy-trans-3-butenoic (AMB) acid irreversibly inhibits pyridoxal phosphate-linked aspartate aminotransferase. The inhibitor is a substrate for the enzyme, and as such is converted into a highly reactive intermediate which chemically reacts with an active site residue, thus i... | Mechanism of the irreversible inhibition of aspartate aminotransferase by the bacterial toxin L-2-amino-4-methoxy-trans-3-butenoic acid. The naturally occurring toxin L-2-amino-4-methoxy-trans-3-butenoic (AMB) acid irreversibly inhibits pyridoxal phosphate-linked aspartate aminotransferase. The inhibitor is a substrate... | [
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PMID:6452 | The activating system of chitin synthetase from Saccharomyces cerevisiae. Purification and properties of the activating factor. | The yeast proteinase that causes activation of the chitin synthetase zymogen has been purified by a procedure that includes affinity chromatography on an agarose column to which the proteinaceous inhibitor of the enzyme had been covalently attached. The purified enzyme yielded a single band upon disc gel electrophoresi... | The activating system of chitin synthetase from Saccharomyces cerevisiae. Purification and properties of the activating factor. The yeast proteinase that causes activation of the chitin synthetase zymogen has been purified by a procedure that includes affinity chromatography on an agarose column to which the proteinace... | [
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PMID:6453 | Accleration of autooxidation of human oxyhemoglobin by aniline and its relation to hemoglobin-catalyzed aniline hydroxylation. | Changes in the ultraviolet/visible spectrum of human oxyferrohemoglobin upon addition of aniline were indicative of a concentration-dependent interaction of aniline with hemoglobin, resulting in accelerated autooxidation of the hemoprotein. Oxygen was found to markedly inhibit this interaction of aniline with oxyhemogl... | Accleration of autooxidation of human oxyhemoglobin by aniline and its relation to hemoglobin-catalyzed aniline hydroxylation. Changes in the ultraviolet/visible spectrum of human oxyferrohemoglobin upon addition of aniline were indicative of a concentration-dependent interaction of aniline with hemoglobin, resulting i... | [
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PMID:6454 | Regulation of glutaminase B in Escherichia coli. I. Purification, properties, and cold lability. | Escherichia coli contains two glutaminases, A and B, with pH optima below pH 5 and above pH 7, respectively. Neither glutaminase A nor B is released from E. coli by osmotic shock. Glutaminase B has been purified 6,000-fold and the purified preparation is estimated to contain about 40% glutaminase B. The enzyme has a mo... | Regulation of glutaminase B in Escherichia coli. I. Purification, properties, and cold lability. Escherichia coli contains two glutaminases, A and B, with pH optima below pH 5 and above pH 7, respectively. Neither glutaminase A nor B is released from E. coli by osmotic shock. Glutaminase B has been purified 6,000-fold ... | [
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PMID:6455 | Effects of divalent cation ionophore A23187 on potassium permeability of rat erythrocytes. | A23187 transports calcium rapidly into rat erythrocytes, apparently by an electroneutral exchange for intracellular magnesium and protons. When red cells are incubated in the absence of any added divalent cations, A23187 transports internal magnesium out of the cells, in exchange for extracellular protons. Magnesium up... | Effects of divalent cation ionophore A23187 on potassium permeability of rat erythrocytes. A23187 transports calcium rapidly into rat erythrocytes, apparently by an electroneutral exchange for intracellular magnesium and protons. When red cells are incubated in the absence of any added divalent cations, A23187 transpor... | [
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PMID:6456 | Yeast alpha-isopropylmalate isomerase. Factors affecting stability and enzyme activity. | Yeast alpha-isopropylmalate isomerase was found to be markedly stabilized by high concentrations of glycerol and (NH4)2SO4. Such conditions of high ionic strength inhibited the enzyme, stabilized the enzyme to heat, and affected kinetic parameters. The isomerase was found to exhibit ionic strength-dependent hysteresis ... | Yeast alpha-isopropylmalate isomerase. Factors affecting stability and enzyme activity. Yeast alpha-isopropylmalate isomerase was found to be markedly stabilized by high concentrations of glycerol and (NH4)2SO4. Such conditions of high ionic strength inhibited the enzyme, stabilized the enzyme to heat, and affected kin... | [
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PMID:6457 | Differential reactivity of the two active site cysteine residues generated on reduction of pig heart lipoamide dehydrogenase. | Reduction of the active center disulfide bond in the flavoprotein pig heart lipoamide dehydrogenase generates two sulfur moieties which are chemically inequivalent in the 2-electron reduced form of the enzyme. Thus 1 cysteine residue is at least 13-fold more reactive than its partner toward iodoacetamide at pH 7.6. Thi... | Differential reactivity of the two active site cysteine residues generated on reduction of pig heart lipoamide dehydrogenase. Reduction of the active center disulfide bond in the flavoprotein pig heart lipoamide dehydrogenase generates two sulfur moieties which are chemically inequivalent in the 2-electron reduced form... | [
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PMID:6458 | Thyroxine-protein interactions. Interaction of thyroxine and triiodothyronine with human thyroxine-binding globulin. | The effect of temperature on the binding of thyroxine and triiodothyronine to thyroxine-binding globulin has been studied by equilibrium dialysis. Inclusion of ovalbumin in the dialysis mixture stabilized thyroxine-binding globulin against losses in binding activity which had been found to occur during equilibrium dial... | Thyroxine-protein interactions. Interaction of thyroxine and triiodothyronine with human thyroxine-binding globulin. The effect of temperature on the binding of thyroxine and triiodothyronine to thyroxine-binding globulin has been studied by equilibrium dialysis. Inclusion of ovalbumin in the dialysis mixture stabilize... | [
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PMID:6459 | Purification and characterization of an endo-beta-galactosidase produced by Diplococcus pneumoniae. | An endo-beta-galactosidase acting on blood group A and B substances was found in the culture fluid of Diplococcus pneumoniae. The enzyme was purified 1000-fold, and its properties were studied in detail. The enzyme preparation, thus obtained, was practically free from various exoglycosidases, endo-beta-N-acetylglucosam... | Purification and characterization of an endo-beta-galactosidase produced by Diplococcus pneumoniae. An endo-beta-galactosidase acting on blood group A and B substances was found in the culture fluid of Diplococcus pneumoniae. The enzyme was purified 1000-fold, and its properties were studied in detail. The enzyme prepa... | [
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PMID:6460 | Cytochrome P-450 of bovine adrenal mitochondria. Ligand binding to two forms resolved by EPR spectroscopy. | The binding of cholest-5-ene-3beta,20alpha-diol (20alpha-hydroxycholesterol), 11-deoxycorticosterone, and aminoglutethimide to cytochrome P-450 in bovine adrenal mitochondria was measured by changes in optical spectra at room temperature and by EPR spectra at 14 K. The two methods provided nearly identical quantitation... | Cytochrome P-450 of bovine adrenal mitochondria. Ligand binding to two forms resolved by EPR spectroscopy. The binding of cholest-5-ene-3beta,20alpha-diol (20alpha-hydroxycholesterol), 11-deoxycorticosterone, and aminoglutethimide to cytochrome P-450 in bovine adrenal mitochondria was measured by changes in optical spe... | [
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PMID:6461 | The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria. | Protoporphyrinogen oxidase, an enzyme which catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX in yeast cells, has been found in several mammalian tissues. It has been extracted from rat liver mitochondria by sonication in the presence of salt and detergent and partially purified. The enzyme is simil... | The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria. Protoporphyrinogen oxidase, an enzyme which catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX in yeast cells, has been found in several mammalian tissues. It has been extracted from rat liver mitochondria... | [
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PMID:6462 | Conformational and thermodynamic properties of apo A-1 of human plasma high density lipoproteins. | Conformational changes of apo A-1, the principal apoprotein of human plasma high density lipoprotein, have been studied by differential scanning calorimetry and ultraviolet difference spectroscopy as a function of temperature, pH, concentration of apoprotein, and urea concentration. Calorimetry shows that apo A-1 (5 to... | Conformational and thermodynamic properties of apo A-1 of human plasma high density lipoproteins. Conformational changes of apo A-1, the principal apoprotein of human plasma high density lipoprotein, have been studied by differential scanning calorimetry and ultraviolet difference spectroscopy as a function of temperat... | [
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PMID:6463 | Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties. | Some physical, catalytic, and regulatory properties of ketopantoate hydroxymethyltransferase (5,10-methylenetetrahydrofolate: alpha-ketoisovalerate hydroxymethyltranferase) from Escherichia coli are described. This enzyme catalyzes the reversible synthesis of ketopantoate (Reaction 1), an essential precursor of pantoth... | Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties. Some physical, catalytic, and regulatory properties of ketopantoate hydroxymethyltransferase (5,10-methylenetetrahydrofolate: alpha-ketoisovalerate hydroxymethyltranferase) from Escherichia coli are described. This enzyme catalyz... | [
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PMID:6464 | Re-evaluation of the kinetics of lactate dehydrogenase-catalyzed chain oxidation of nicotinamide adenine dinucleotide by superoxide radicals in the presence of ethylenediaminetetraacetate. | The chain oxidation of lactate dehydrogenase-bound NADH initiated by superoxide radicals and propagated by oxygen was studied with pulse radiolysis. The kinetic parameters were re-evaluated in a system with carefully purified reagents (water and other chemicals) and in the presence of EDTA. The rate constant for the ox... | Re-evaluation of the kinetics of lactate dehydrogenase-catalyzed chain oxidation of nicotinamide adenine dinucleotide by superoxide radicals in the presence of ethylenediaminetetraacetate. The chain oxidation of lactate dehydrogenase-bound NADH initiated by superoxide radicals and propagated by oxygen was studied with ... | [
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PMID:6465 | Purification and characterization of the alpha-D-mannosidase of rat liver cytosol. | Three forms of alpha-D-mannosidase have previously been identified in rat liver, and each is localized in a different subcellular fraction: lysosomes, Golgi membranes, and cytosol. This communication reports the purification and characterization the cytosolic form. The enzyme was purified 12,000-fold in good yield to a... | Purification and characterization of the alpha-D-mannosidase of rat liver cytosol. Three forms of alpha-D-mannosidase have previously been identified in rat liver, and each is localized in a different subcellular fraction: lysosomes, Golgi membranes, and cytosol. This communication reports the purification and characte... | [
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PMID:6466 | Effects of two ionizing groups on the active site of human carbonic anhydrase B. | Investigation of some pH-dependent properties of human erythrocyte carbonic anhydrase B indicate that the active site is influenced by at least two charged groups. The properties studied include the pH dependence of inhibition of native, monocarboxamidomethyl, and monocarboxymethyl enzymes by iodide ion and the pH depe... | Effects of two ionizing groups on the active site of human carbonic anhydrase B. Investigation of some pH-dependent properties of human erythrocyte carbonic anhydrase B indicate that the active site is influenced by at least two charged groups. The properties studied include the pH dependence of inhibition of native, m... | [
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PMID:6467 | Measurement of the oxidation-reduction potentials for two-electron and four-electron reduction of lipoamide dehydrogenase from pig heart. | The oxidation-reduction potential, E2, for the couple oxidized lipoamide dehydrogenase/2-electron reduced lipoamide dehydrogenase has been determined by measurement of equilibria of these enzyme species with lipoamide and dihydrolipoamide or with oxidized and reduced azine dyes. E2 is -0.280 V at pH 7, and deltaE2/delt... | Measurement of the oxidation-reduction potentials for two-electron and four-electron reduction of lipoamide dehydrogenase from pig heart. The oxidation-reduction potential, E2, for the couple oxidized lipoamide dehydrogenase/2-electron reduced lipoamide dehydrogenase has been determined by measurement of equilibria of ... | [
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0.011577065102756023,
-0.06438274681568146,
0.05976226180791855,
-0.0116352... |
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