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PMID:6719 | The effects of angiotensin I and angiotensin II on the isolated tracheal muscle of the cat. | The effects of Asp1-beta-amide-Val5-angiotensin II (A II) and Asp1-Ile5-angiotensin I (A I) have been studied on the isolated continuously superfused cat tracheal muscle contracted by 5-hydroxytryptamine (5-HT). Both peptides have been shown to induce dose-dependent relaxation on this muscle. Similar effects have been ... | The effects of angiotensin I and angiotensin II on the isolated tracheal muscle of the cat. The effects of Asp1-beta-amide-Val5-angiotensin II (A II) and Asp1-Ile5-angiotensin I (A I) have been studied on the isolated continuously superfused cat tracheal muscle contracted by 5-hydroxytryptamine (5-HT). Both peptides ha... | [
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PMID:6720 | Anticholinergic activity of antipsychotic drugs in relation to their extrapyramidal effects. | Antipsychotic drugs were evaluated with two indices of anticholinergic activity, mydriasis in mice in vivo and antagonism of carbamylcholine-induced contractions of guinea-pig tracheal strips in vitro. The drugs from most to least potent as oral mydriatic agents were mepazine, clozapine, thioridazine, promazine and chl... | Anticholinergic activity of antipsychotic drugs in relation to their extrapyramidal effects. Antipsychotic drugs were evaluated with two indices of anticholinergic activity, mydriasis in mice in vivo and antagonism of carbamylcholine-induced contractions of guinea-pig tracheal strips in vitro. The drugs from most to le... | [
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PMID:6721 | Some factors influencing dissolution from salicylic acid-urea solid dispersions. | Solid dispersion systems of salicylic acid-urea have been prepared using a fusion method. Two different methods of cooling the melt were employed, rapid cooling in liquid nitrogen and slow cooling in air. Differential scanning calorimetry and an X-ray diffraction technique were employed to investigate the nature of the... | Some factors influencing dissolution from salicylic acid-urea solid dispersions. Solid dispersion systems of salicylic acid-urea have been prepared using a fusion method. Two different methods of cooling the melt were employed, rapid cooling in liquid nitrogen and slow cooling in air. Differential scanning calorimetry ... | [
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PMID:6747 | Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives. | Light scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphenine hydrochloride, piperidolate hydrochloride, benztropine mesylate, orphenadrine hydrochloride, chlorphenoxamine hyd... | Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives. Light scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphen... | [
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PMID:6748 | The crystallization behaviour of sulphathiazole. | Previous investigations into the dissolution kinetics of sulphathiazole Form 1 have shown the process to be first order with respect to driving force. However, below 37 degrees first order kinetics did not apply, due to the surface reaction becoming the rate controlling factor. The present study examines the kinetics o... | The crystallization behaviour of sulphathiazole. Previous investigations into the dissolution kinetics of sulphathiazole Form 1 have shown the process to be first order with respect to driving force. However, below 37 degrees first order kinetics did not apply, due to the surface reaction becoming the rate controlling ... | [
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PMID:6749 | Anomalies in some properties of powder mixtures. | Mixtures of lactose and paracetamol and of lactose and oxytetracycline exhibit anomalous properties. The mean particle sizes, tensile strengths and flow properties of the mixtures are not proportionally intermediate between those of the constituents. The results are ascribed to changes that occur in the packing arrange... | Anomalies in some properties of powder mixtures. Mixtures of lactose and paracetamol and of lactose and oxytetracycline exhibit anomalous properties. The mean particle sizes, tensile strengths and flow properties of the mixtures are not proportionally intermediate between those of the constituents. The results are ascr... | [
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PMID:6750 | Fluorimetric assay of tetracycline mixtures. | A simple and precise fluorimetric method is described for the simultaneous assay in plasma of a mixture containing chlortetracycline, demethylchlortetracycline and tetracycline. Assay within the therapeutic ranges of 0-5 mg litre(-1) is achieved by formation of strongly fluorescent aluminum/tetracycline complexes, with... | Fluorimetric assay of tetracycline mixtures. A simple and precise fluorimetric method is described for the simultaneous assay in plasma of a mixture containing chlortetracycline, demethylchlortetracycline and tetracycline. Assay within the therapeutic ranges of 0-5 mg litre(-1) is achieved by formation of strongly fluo... | [
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PMID:6751 | Preliminary investigations of the metabolism and pharmacological activity of beta-hydroxytryptamines in mammals. | beta-Hydroxytryptamine and beta-hydroxy-5-hydroxytryptamine were incubated with rat liver slices and oxidative deamination was established as the main route of metabolism: in both instances the corresponding indole-3-glycollic acids and indole-3-ethane diols were the major metabolites. However, the rates of deamination... | Preliminary investigations of the metabolism and pharmacological activity of beta-hydroxytryptamines in mammals. beta-Hydroxytryptamine and beta-hydroxy-5-hydroxytryptamine were incubated with rat liver slices and oxidative deamination was established as the main route of metabolism: in both instances the corresponding... | [
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PMID:6752 | Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system. | In gallamine-immobilized cats, the caudate nucleus and the nucleus accumbens septi were perfused by means of a push-pull cannula and dopamine was measured in the perfusate. Chlorpromazine (10 mg kg(-1)) and clozapine (20 mg kg(-1)), administered intravenously, enhanced the release of dopamine. The effect of chlorpromaz... | Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system. In gallamine-immobilized cats, the caudate nucleus and the nucleus accumbens septi were perfused by means of a push-pull cannula and dopamine was measured in the perfusate. Chlorpromazine (10 mg kg(-1)) and clozapine ... | [
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PMID:6753 | An in vitro method for the study of beta-receptor mediated effects on slow contracting skeletal muscle. | The soleus muscle of a guinea-pig was dissected out under pentobarbitone anaesthesia and mounted on a holder in an organ bath containing Krebs solution. The tendon was attached to a force transducer and subtetanic contractions were evoked by electrical field stimulation (0.5 ms pulses at 10-12 Hz for 1.5 or 3 s every 2... | An in vitro method for the study of beta-receptor mediated effects on slow contracting skeletal muscle. The soleus muscle of a guinea-pig was dissected out under pentobarbitone anaesthesia and mounted on a holder in an organ bath containing Krebs solution. The tendon was attached to a force transducer and subtetanic co... | [
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PMID:6754 | Effects of alpha-methyldopa on blood pressure in the anaesthetized dog. | Intravenous infusion over 1 h of 20 mg kg(-1) of alpha-methyldopa produced hypotension in the anaesthetized dog. The magnitude of this effect was, however, inversely correlated with bodyweight. Either rapid intravenous injection of alpha-methyldopa or slow infusion of alpha-methyldopate, was less effective in lowering ... | Effects of alpha-methyldopa on blood pressure in the anaesthetized dog. Intravenous infusion over 1 h of 20 mg kg(-1) of alpha-methyldopa produced hypotension in the anaesthetized dog. The magnitude of this effect was, however, inversely correlated with bodyweight. Either rapid intravenous injection of alpha-methyldopa... | [
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PMID:6755 | The effect of cholinesterase inhibitors on the antimuscarinic effect of hemicholinium-3 (HC-3) in the rat. | The effect of hemicholinium-3 (HC-3) on responses of the rat isolated bladder and ileum to acetylcholine and carbachol was investigated in the absence and presence of a number of anticholinesterases. Responses of the bladder to acetylcholine were potentiated by DFP, edrophonium, BW284C51 and physostigmine but were unaf... | The effect of cholinesterase inhibitors on the antimuscarinic effect of hemicholinium-3 (HC-3) in the rat. The effect of hemicholinium-3 (HC-3) on responses of the rat isolated bladder and ileum to acetylcholine and carbachol was investigated in the absence and presence of a number of anticholinesterases. Responses of ... | [
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PMID:6771 | Rapid and sensitive colorimetric determination of cobalt(II). | A highly selective and sensitive spectrophotometric determination of cobalt (II) was developed. 7-Nitroso-8-hydroxyquinoline-5-sulfonic acid sodium salt was used as the chromogenic reagent for color development. Although other metals form colored chelates with the ligand, it was possible to develop a selective method u... | Rapid and sensitive colorimetric determination of cobalt(II). A highly selective and sensitive spectrophotometric determination of cobalt (II) was developed. 7-Nitroso-8-hydroxyquinoline-5-sulfonic acid sodium salt was used as the chromogenic reagent for color development. Although other metals form colored chelates wi... | [
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PMID:6772 | High-pressure liquid chromatographic determination of the 15-epimer of dinoprost in bulk drug. | The p-nitrophenacyl esters of dinoprost and its 15-epimer are well resolved using high-pressure liquid chromatography. Quantitation was achieved using the internal standard technique. The specially synthesized diphenylurea ester of cholic acid was found to be a model internal standard. Graphs of peak height ratios of t... | High-pressure liquid chromatographic determination of the 15-epimer of dinoprost in bulk drug. The p-nitrophenacyl esters of dinoprost and its 15-epimer are well resolved using high-pressure liquid chromatography. Quantitation was achieved using the internal standard technique. The specially synthesized diphenylurea es... | [
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PMID:6773 | Effect of edetate disodium and reduced glutathione on absorption of acetazolamide from GI tract of rats. | The absorption of acetazolamide suspensions from in situ rat gastric and intestinal loop segments was studied. In 1 hr, 66.2 and 64.3% remained unabsorbed from the rat stomach and intestine, respectively. Although 1% (w/v) reduced glutathione and 1% (w/v) (24 mM) edetate disodium had no effect on gastric absorption, dr... | Effect of edetate disodium and reduced glutathione on absorption of acetazolamide from GI tract of rats. The absorption of acetazolamide suspensions from in situ rat gastric and intestinal loop segments was studied. In 1 hr, 66.2 and 64.3% remained unabsorbed from the rat stomach and intestine, respectively. Although 1... | [
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PMID:6774 | Chlorpromazine metabolism VIII: blood levels of chlorpromazine and its sulfoxide in schizophrenic patients. | A procedure was standardized for extracting chloropromazine and its sulfoxide from the blood and for applying a recently developed fluorometric assay method to determine blood levels of these two compounds in schizophrenic patients receiving chlorpromazine therapy. The described methodology opens avenues for performing... | Chlorpromazine metabolism VIII: blood levels of chlorpromazine and its sulfoxide in schizophrenic patients. A procedure was standardized for extracting chloropromazine and its sulfoxide from the blood and for applying a recently developed fluorometric assay method to determine blood levels of these two compounds in sch... | [
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PMID:6775 | Effects of various hydrodynamic conditions on dissolution rate determinations. | An automated potentiometric procedure was used in dissolution rate studies to determine the effects of various hydrodynamic conditions on dissolution rate determinations. Changes in the hydrodynamics of the system resulted from using various sizes and shapes of dissolution vessels. Dissolution rate constants for benzoi... | Effects of various hydrodynamic conditions on dissolution rate determinations. An automated potentiometric procedure was used in dissolution rate studies to determine the effects of various hydrodynamic conditions on dissolution rate determinations. Changes in the hydrodynamics of the system resulted from using various... | [
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PMID:6776 | Determination of tinidazole in tablets by dc polarography. | A polarographic method was developed for determining tinidazole in tablets. The substance is extracted from the sample with water, pH 6.8 Britton-Robinson buffer is added to an aliquot, and the solution is polarographed at the dropping mercury electrode versus the saturated calomel electrode. The polarographic wave is ... | Determination of tinidazole in tablets by dc polarography. A polarographic method was developed for determining tinidazole in tablets. The substance is extracted from the sample with water, pH 6.8 Britton-Robinson buffer is added to an aliquot, and the solution is polarographed at the dropping mercury electrode versus ... | [
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PMID:6777 | Spectrophotometric determination of diphenhydramine hydrochloride using dipicrylamine. | A spectrophotometric procedure for the determination of diphenhydramine hydrochloride based on the reaction with dipicrylamine was developed. A yellow complex forms and is easily extractable by chloroform at pH 5. The mole ratio of diphenydramine hydrochloride to dipicrylamine in the complex is 1:3. The absorbance of t... | Spectrophotometric determination of diphenhydramine hydrochloride using dipicrylamine. A spectrophotometric procedure for the determination of diphenhydramine hydrochloride based on the reaction with dipicrylamine was developed. A yellow complex forms and is easily extractable by chloroform at pH 5. The mole ratio of d... | [
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PMID:6778 | Application of trihydroxyindole reaction to methanesulfonanilides: fluorometric analysis for soterenol and mesuprine. | Methanesulfonanilides, like soterenol and mesuprine, which are bioisosteric with adrenergic catecholamines, form fluorescent species when subjected to the trihydroxyindole reaction. Presumably, the fluorescence is due to adrenolutin-like species formed from aminochrome intermediates. Fluorescence was not induced in a r... | Application of trihydroxyindole reaction to methanesulfonanilides: fluorometric analysis for soterenol and mesuprine. Methanesulfonanilides, like soterenol and mesuprine, which are bioisosteric with adrenergic catecholamines, form fluorescent species when subjected to the trihydroxyindole reaction. Presumably, the fluo... | [
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PMID:6779 | Continuous dissolution rate determination as a function of the pH of the medium. | A method was developed for varying the pH of the medium during dissolution rate studies of timed-release tablets with the aid of compressed, totally soluble, alkaline powder mixtures. Commercial as well as experimental timed-release capsules or tablets were used as models, and dissolution rates were determined at pH 1.... | Continuous dissolution rate determination as a function of the pH of the medium. A method was developed for varying the pH of the medium during dissolution rate studies of timed-release tablets with the aid of compressed, totally soluble, alkaline powder mixtures. Commercial as well as experimental timed-release capsul... | [
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PMID:6780 | Controlled flocculation of coarse suspensions by colloidally dispersed solids I: Interaction of bismuth subnitrate with bentonite. | Deflocculated suspensions of coarse powders tend to cake as the individual particles settle out and form compact, cohesive sediments. Limited flocculation results in looser sediments because the settled-out flocs incorporate large amounts of the liquid suspending medium. Controlled flocculation of bismuth subnitrate su... | Controlled flocculation of coarse suspensions by colloidally dispersed solids I: Interaction of bismuth subnitrate with bentonite. Deflocculated suspensions of coarse powders tend to cake as the individual particles settle out and form compact, cohesive sediments. Limited flocculation results in looser sediments becaus... | [
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PMID:6781 | Urinary excretion of probenecid and its metabolites in humans as a function of dose. | A GLC assay was used to study the excretion of probenecid and its metabolites in the urine of human subjects following oral doses of 0.5, 1, and 2 g. From 75 to 88% of the dose was found in the urine. The major metabolite, probenecid acyl glucuronide, accounted for 34-47% of the dose. Approximately equal amounts (10-1... | Urinary excretion of probenecid and its metabolites in humans as a function of dose. A GLC assay was used to study the excretion of probenecid and its metabolites in the urine of human subjects following oral doses of 0.5, 1, and 2 g. From 75 to 88% of the dose was found in the urine. The major metabolite, probenecid ... | [
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PMID:6782 | Nitrofurantoin solubility in aqueous urea and creatinine solutions. | Experiments were carried out to determine the effect of urea and creatinine on the solubility of nitrofurantoin in water at different temperature and pH conditions. The addition of urea to aqueous media increased nitrofurantoin solubility up to a maximum concentration level and then decreased solubility at higher urea ... | Nitrofurantoin solubility in aqueous urea and creatinine solutions. Experiments were carried out to determine the effect of urea and creatinine on the solubility of nitrofurantoin in water at different temperature and pH conditions. The addition of urea to aqueous media increased nitrofurantoin solubility up to a maxim... | [
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PMID:6783 | Influence of pH and route of injection on acute toxicity of tetracycline in mice. | Some LD50 determinations for tetracycline hydrochloride in mice were carried out over a range of pH values, using both the intraperitoneal and the subcutaneous routes of injection. Depending on the pH of the formulation, either water or a solvent system of water and 60% (v/v) propylene glycol was employed thus ensuring... | Influence of pH and route of injection on acute toxicity of tetracycline in mice. Some LD50 determinations for tetracycline hydrochloride in mice were carried out over a range of pH values, using both the intraperitoneal and the subcutaneous routes of injection. Depending on the pH of the formulation, either water or a... | [
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PMID:6784 | Monoamine oxidase inhibition and the induction of ponto-geniculo-occipital wave activity by reserpine in the cat. | Reserpine induces ponto-geniculo-occipital wave activity similar to that seen in the cat during the rapid eye movement phase of sleep. This action of reserpine was blocked by the monoamine oxidase inhibitors, pheniprazine, harmaline and clorgyline, but not deprenyl or its demethylated analog. After a single dose (20 mg... | Monoamine oxidase inhibition and the induction of ponto-geniculo-occipital wave activity by reserpine in the cat. Reserpine induces ponto-geniculo-occipital wave activity similar to that seen in the cat during the rapid eye movement phase of sleep. This action of reserpine was blocked by the monoamine oxidase inhibitor... | [
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PMID:6785 | Further studies on angiotensin tachyphylaxis. | Rabbit aorta and rat fundus do not display tachyphylaxis to angiotensin II (Asp1)angiotensin II) at 37 degrees C. These tissues do, however, display tachyphylaxis to [Sar1]angiotensin II (N-methylglycine 1 angiotensin II) and [dimethylglycine angiotensin II, respectively, at this temperature. At 22 degrees C, both tiss... | Further studies on angiotensin tachyphylaxis. Rabbit aorta and rat fundus do not display tachyphylaxis to angiotensin II (Asp1)angiotensin II) at 37 degrees C. These tissues do, however, display tachyphylaxis to [Sar1]angiotensin II (N-methylglycine 1 angiotensin II) and [dimethylglycine angiotensin II, respectively, a... | [
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PMID:6786 | Studies on adrenal phenylethanolamine N- methyltransferase (PNMT) with S K & F 64139, a selective inhibitor. | SK&F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard assay system was 1 X 10(-7) M. Kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is uncompetitive when S-adenosylmethionine is the variable substrate. ... | Studies on adrenal phenylethanolamine N- methyltransferase (PNMT) with S K & F 64139, a selective inhibitor. SK&F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard assay system was 1 X 10(-7) M. Kinetically, the compound is a competitive in... | [
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PMID:6787 | The effects of metoclopramide in modifying the response of isolated guinea-pig ileum to various agonists. | Metoclopramide has a dual effect on intestinal smooth muscle. Low concentrations of metoclopramide cause potentiation of the responses to substance P, acetylcholine, histamine and barium chloride on the guinea-pig ileum. Higher concentrations produce a depression of smooth muscle responses which is characteristic of th... | The effects of metoclopramide in modifying the response of isolated guinea-pig ileum to various agonists. Metoclopramide has a dual effect on intestinal smooth muscle. Low concentrations of metoclopramide cause potentiation of the responses to substance P, acetylcholine, histamine and barium chloride on the guinea-pig ... | [
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PMID:6788 | Statistical parameters of transmitter release at frog neuromuscular junctions treated with guanidine or tetraethylammonium. | Transmitter release at Mg++ -depressed frog neuromuscular junctions can be described using binomial statistics. The number of quanta (m) released by the nerve terminal action potential is directly proportional to the mean probability (p) that a quantum will be released and the number of quanta available for release (n)... | Statistical parameters of transmitter release at frog neuromuscular junctions treated with guanidine or tetraethylammonium. Transmitter release at Mg++ -depressed frog neuromuscular junctions can be described using binomial statistics. The number of quanta (m) released by the nerve terminal action potential is directly... | [
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PMID:6789 | Effect of fatty acids on the disposition of ammonia. | Subcoma doses of fatty acids and ammonium salts injected intraperitoneally at the same time into rats or cats act synergistically to produce coma. Under these circumstances, the blood ammonia, is more than double that when the NH4+ is given alone. After these observations a rat liver homogenate system was utilized to s... | Effect of fatty acids on the disposition of ammonia. Subcoma doses of fatty acids and ammonium salts injected intraperitoneally at the same time into rats or cats act synergistically to produce coma. Under these circumstances, the blood ammonia, is more than double that when the NH4+ is given alone. After these observa... | [
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PMID:6790 | Microsomal reductive glycosidase. | Rat liver microsomes contain a phenobarbital inducible, NADPH dependent, reductive glycosidase capable of cleaving several anthracycline antibiotics, including adriamycin and daunorubicin, to deoxyaglycone products. The pH optimum for the reaction ranges from 7 to 7.4, and no metal requirements are noted. Molecular oxy... | Microsomal reductive glycosidase. Rat liver microsomes contain a phenobarbital inducible, NADPH dependent, reductive glycosidase capable of cleaving several anthracycline antibiotics, including adriamycin and daunorubicin, to deoxyaglycone products. The pH optimum for the reaction ranges from 7 to 7.4, and no metal req... | [
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PMID:6791 | Neutral protease activity and erythropoietin production in the rat after cobalt administration. | The generation of erythropoietin purportedly involves the interaction of an enzyme, of renal origin, and a circulating plasma protein substrate. Cobalt, which has the capacity to stimulate erythropoietin formation, was evaluated for its effects on renal and plasma protease activity; in addition, the nature of the eryth... | Neutral protease activity and erythropoietin production in the rat after cobalt administration. The generation of erythropoietin purportedly involves the interaction of an enzyme, of renal origin, and a circulating plasma protein substrate. Cobalt, which has the capacity to stimulate erythropoietin formation, was evalu... | [
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PMID:6792 | Cholestyramine-induced inhibition of salicylazosulfapyridine (sulfasalazine) metabolism by rat intestinal microflora. | The effect of multiple oral administration of the hypocholesterolemic agent cholestyramine (a strongly basic anion-exchange resin) on the metabolism of salicylazosulfapyridine by microflora present in the colon and cecum was assessed in conventional rats by following the time course of salicylazosulfapyridine and its m... | Cholestyramine-induced inhibition of salicylazosulfapyridine (sulfasalazine) metabolism by rat intestinal microflora. The effect of multiple oral administration of the hypocholesterolemic agent cholestyramine (a strongly basic anion-exchange resin) on the metabolism of salicylazosulfapyridine by microflora present in t... | [
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PMID:6793 | The correlation between antinociceptive activity of narcotics and their antagonists as measured in the mouse tail-flick test and increased synthesis of brain catecholamines. | The effects of several narcotics, narcotic antagonists-analgesics and narcotic antagonists on the synthesis of dopamine and norepinephrine in mouse brain were estimated and related to their activity in the tail-flick test. Catecholamine synthesis was estimated by measuring the accumulation of 3H-dopamine and 3H-norepin... | The correlation between antinociceptive activity of narcotics and their antagonists as measured in the mouse tail-flick test and increased synthesis of brain catecholamines. The effects of several narcotics, narcotic antagonists-analgesics and narcotic antagonists on the synthesis of dopamine and norepinephrine in mous... | [
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PMID:6794 | Evaluation of the discriminative effects of morphine in the rat. | The discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete trial avoidance task. Stimulus control of behavior was attained with a dose of morphine one-third to one-tenth of that used in previous studies. Morphine produced dose-related discriminative effects over a 100-fold do... | Evaluation of the discriminative effects of morphine in the rat. The discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete trial avoidance task. Stimulus control of behavior was attained with a dose of morphine one-third to one-tenth of that used in previous studies. Morphin... | [
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PMID:6795 | Protein synthesis by a cell-free preparation from the bird malaria, Plasmodium lophurae. | Cytoplasmic polyribosomes were isolated from the avian malaria parasite Plasmodium lophurae by lysis with 0.15% Triton X-100 followed by high speed centrifugation through a discontinuous sucrose gradient. Polyribosomes were protected from nuclease degradation using 100 mug/ml heparin or 50 mug/ml dextran sulfate. Cell-... | Protein synthesis by a cell-free preparation from the bird malaria, Plasmodium lophurae. Cytoplasmic polyribosomes were isolated from the avian malaria parasite Plasmodium lophurae by lysis with 0.15% Triton X-100 followed by high speed centrifugation through a discontinuous sucrose gradient. Polyribosomes were protect... | [
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PMID:6796 | The serine hydroxymethyltransferase of Plasmodium lophurae. | Plasmodium lophurae serine hydroxymethyltransferase (EC 2.1.2.1) was partially purified and characterized by (NH4)2SO4 fractionation and chromatography on Sephadex G-100. The enzyme, precipitated by 3.0.3.3 M (NH4)2SO4, had a molecular weight of 68,300 as estimated by exclusion chromatography on G-100. The pH optimum o... | The serine hydroxymethyltransferase of Plasmodium lophurae. Plasmodium lophurae serine hydroxymethyltransferase (EC 2.1.2.1) was partially purified and characterized by (NH4)2SO4 fractionation and chromatography on Sephadex G-100. The enzyme, precipitated by 3.0.3.3 M (NH4)2SO4, had a molecular weight of 68,300 as esti... | [
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PMID:6797 | Pentamidine transport and sensitivity in brucei-group trypanosomes. | Sensitivity to pentamidine of bloodstream forms and culture forms of Trypanosoma brucei brucei, strains of this subspecies, and strains of T. brucei rhodesiense characteristically differs in vitro. Analyses of transport parameters for pentamidine uptake in these organisms show differences that correspond with drug sens... | Pentamidine transport and sensitivity in brucei-group trypanosomes. Sensitivity to pentamidine of bloodstream forms and culture forms of Trypanosoma brucei brucei, strains of this subspecies, and strains of T. brucei rhodesiense characteristically differs in vitro. Analyses of transport parameters for pentamidine uptak... | [
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PMID:6798 | The influence of growth medium on the interactions between Bordetella pertussis and Staphylococcus aureus. | Previous observers showed that many strains of Staphylococcus aureus stimulated the growth of Bordetella pertussis but we have found the reverse: the growth of all available strains of B. pertussis on charcoal-agar medium was inhibited by a standard strain of S. aureus; and 17 of 18 strains of S. aureus (as well as sev... | The influence of growth medium on the interactions between Bordetella pertussis and Staphylococcus aureus. Previous observers showed that many strains of Staphylococcus aureus stimulated the growth of Bordetella pertussis but we have found the reverse: the growth of all available strains of B. pertussis on charcoal-aga... | [
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PMID:6799 | Localization of calcium binding sites associated with the calcium spike in barnacle muscle. | La ion behaves as a competitive inhibitor of Ca ions on the calcium spike in the giant muscle fiber of the barnacle, Balanus nubilus. La-treated muscle fibers, in which the rate of rise of the spike was diminished to a known degree, have been examined with the electron-microscope. In such fibers dense particles are see... | Localization of calcium binding sites associated with the calcium spike in barnacle muscle. La ion behaves as a competitive inhibitor of Ca ions on the calcium spike in the giant muscle fiber of the barnacle, Balanus nubilus. La-treated muscle fibers, in which the rate of rise of the spike was diminished to a known deg... | [
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PMID:6801 | Characterization of Whitney's Clethrionomy gapperi virus isolates from Massachusetts. | Six strains of virus were recovered from the blood and/or liver of five Clethrionomys gapperi ochraceus trapped in southeastern Massachusetts during 1969. Biological, antigenic and physiochemical properties of these isolates are reported. USA M-2268a was selected as the reference strain. This strain was identical by co... | Characterization of Whitney's Clethrionomy gapperi virus isolates from Massachusetts. Six strains of virus were recovered from the blood and/or liver of five Clethrionomys gapperi ochraceus trapped in southeastern Massachusetts during 1969. Biological, antigenic and physiochemical properties of these isolates are repor... | [
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PMID:6802 | Sea-blue histiocytes in a case of Takayasu arteritis. | Arteriographic, immunological, and bone marrow studies of a young woman with Takayasu arteritis disclosed the presence of sea-blue histiocytes in her bone marrow. We know of no other similar reports. | Sea-blue histiocytes in a case of Takayasu arteritis. Arteriographic, immunological, and bone marrow studies of a young woman with Takayasu arteritis disclosed the presence of sea-blue histiocytes in her bone marrow. We know of no other similar reports. | [
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PMID:6805 | Quantitative and qualitative determinations of the combined effect of tetracycline and oleandomycin. I. In vitro effect. | Growth inhibitory effect of combined treatment of tetracycline (TC) and oleandomycin (OM), at a ratio of 2:1, on certain species of pathogenic bacteria including drug-resistant ones was examined. By the crossed paper strip method, synergistic effects were demonstrated against 9 of the 16 strains of Staphylococcus aureu... | Quantitative and qualitative determinations of the combined effect of tetracycline and oleandomycin. I. In vitro effect. Growth inhibitory effect of combined treatment of tetracycline (TC) and oleandomycin (OM), at a ratio of 2:1, on certain species of pathogenic bacteria including drug-resistant ones was examined. By ... | [
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PMID:6806 | Elevated plasma renin activity in aortitis syndrome. | Plasma renin activity (PRA) was measured in 38 cases of aortitis syndrome. The values of resting peripheral vein blood PRA were 32.2 +/- 4.2 (SE) mmug/ml. These values were 3 times higher than those of normal subjects. Hypertension due to renal arterial stenosis was observed in 18 cases. Their resting PRA values were 4... | Elevated plasma renin activity in aortitis syndrome. Plasma renin activity (PRA) was measured in 38 cases of aortitis syndrome. The values of resting peripheral vein blood PRA were 32.2 +/- 4.2 (SE) mmug/ml. These values were 3 times higher than those of normal subjects. Hypertension due to renal arterial stenosis was ... | [
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PMID:6807 | Perinephritis hypertension in monkeys. I. An increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis. | The renal parenchyma of 5 crub-eating monkeys (Macaca irus) was wrapped by cellophane, and plasma renin activity, blood pressure and vascular permeability of ocular ground were measured in comparison with 5 unoperated control monkeys. The results demonstrated that increases of systolic arterial pressure, plasma renin a... | Perinephritis hypertension in monkeys. I. An increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis. The renal parenchyma of 5 crub-eating monkeys (Macaca irus) was wrapped by cellophane, and plasma renin activity, blood pressure and vascular permeability of ocular... | [
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PMID:6808 | Hemodynamics of experimentally hypertensive rats in conscious and anesthetized states. | Cardiac output was measured by a pulse contour method in reno-vascular hypertensive rats, deoxycorticosterone (DOC) hypertensive rats and normotensive control Wistar rats in the conscious state. All rats were male in sex and 12-13 weeks of age (2-3 weeks after operation in the hypertensive rats). Cardiac output per bod... | Hemodynamics of experimentally hypertensive rats in conscious and anesthetized states. Cardiac output was measured by a pulse contour method in reno-vascular hypertensive rats, deoxycorticosterone (DOC) hypertensive rats and normotensive control Wistar rats in the conscious state. All rats were male in sex and 12-13 we... | [
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PMID:6813 | Enhancement of sulphatide metabolism in the hypertrophied kidney of C3H/He mouse with reference to [Na+, K+]-dependent ATPase. | Sulphatide (cerebroside sulphate) metabolism of C3H/He mouse kidney was investigated in the course of compensatory renal hypertrophy in association with the change of [Na+,K+]-dependent ATPase, arylsulfatase A and beta-galactosidase activity. A remarkable increase in 35S incorporation into kidney sulphatide was observe... | Enhancement of sulphatide metabolism in the hypertrophied kidney of C3H/He mouse with reference to [Na+, K+]-dependent ATPase. Sulphatide (cerebroside sulphate) metabolism of C3H/He mouse kidney was investigated in the course of compensatory renal hypertrophy in association with the change of [Na+,K+]-dependent ATPase,... | [
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PMID:6814 | Effect of taurine on alteration in adrenal functions induced by stress. | When rats were exposed to immobilized cold stress, adrenaline content in the adrenal gland as well as noradrenaline content in the brain stem were reduced drastically, while noradrenaline content in the atria was not altered by the application of stress. Oral administrations of taurine (4-7 g/kg/day, for 3 days) preven... | Effect of taurine on alteration in adrenal functions induced by stress. When rats were exposed to immobilized cold stress, adrenaline content in the adrenal gland as well as noradrenaline content in the brain stem were reduced drastically, while noradrenaline content in the atria was not altered by the application of s... | [
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PMID:6815 | A clinical comparison of syrup of ipecac and apomorphine use in adults. | A prospective, randomized study was performed to compare syrup of ipecac to apomorphine as the emetic of choice in poisoning cases. Of the 28 adults studied, 15 patients (54%) received 30 ml of ipecac orally and 13 received 0.1 mg/kg apomorphine subcutaneously. Emesis was successfully induced with initial therapy in 13... | A clinical comparison of syrup of ipecac and apomorphine use in adults. A prospective, randomized study was performed to compare syrup of ipecac to apomorphine as the emetic of choice in poisoning cases. Of the 28 adults studied, 15 patients (54%) received 30 ml of ipecac orally and 13 received 0.1 mg/kg apomorphine su... | [
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PMID:6816 | Monitoring resuscitation of primates from hemorrhagic and septic shock. | Monitoring data in 16 primates subjected to septic or hemorrhagic shock and resuscitated with various solutions is presented. From a paractical standpoint, central venous pressure and urine output appear to be the best indices to use in the emergency department for resuscitation of the shock victim. The sophisticated m... | Monitoring resuscitation of primates from hemorrhagic and septic shock. Monitoring data in 16 primates subjected to septic or hemorrhagic shock and resuscitated with various solutions is presented. From a paractical standpoint, central venous pressure and urine output appear to be the best indices to use in the emergen... | [
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PMID:6819 | [Fertility after treatment with HCG for undescended testes (author's tranls)]. | 151 out of 212 adolescents having had been treated by human chorionic gonadotrophin (HCG) before puberty because of undescended testes, were re-examined 7 to 12 years later at an individual age of at least 17 years. In 121 of them a semen specimen for sperm counts could be obtained. In 10 patients, however, no ejaculat... | [Fertility after treatment with HCG for undescended testes (author's tranls)]. 151 out of 212 adolescents having had been treated by human chorionic gonadotrophin (HCG) before puberty because of undescended testes, were re-examined 7 to 12 years later at an individual age of at least 17 years. In 121 of them a semen sp... | [
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PMID:6820 | [Carbromal intoxication: influence of hemodialysis and hemoperfusion]. | It has been demonstrated with an in vitro model that hemoperfusion through Amberlite XAD4 or coated charcoal containing cartridges eliminates carbromal and its ureid derivatives more efficiently than hemodialysis. The following clearancs were measured in vitro (blood flow: 200 ml/min): Coil dialyser (1 m2): 55-85 ml/mi... | [Carbromal intoxication: influence of hemodialysis and hemoperfusion]. It has been demonstrated with an in vitro model that hemoperfusion through Amberlite XAD4 or coated charcoal containing cartridges eliminates carbromal and its ureid derivatives more efficiently than hemodialysis. The following clearancs were measur... | [
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PMID:6826 | Monitoring of midmyocardial and subendocardial pH in normal and ischemic ventricles. | Midmyocardial and subendocardial pH monitoring was used as an indirect method for continuous evaluation of regional canine myocardial ischemia. Left ventricular midmyocardial pH (pHm) at 4 mm. depth was monitored in 10 dogs, under resting conditions, by means of a 5 mm. Beckman pH probe. pHm was 6.96 +/- 0.03, recorded... | Monitoring of midmyocardial and subendocardial pH in normal and ischemic ventricles. Midmyocardial and subendocardial pH monitoring was used as an indirect method for continuous evaluation of regional canine myocardial ischemia. Left ventricular midmyocardial pH (pHm) at 4 mm. depth was monitored in 10 dogs, under rest... | [
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PMID:6827 | [The use of "mesh graft" in traumatology]. | Vandeput and J. Tanner's method for the reconstruction of the reticular grafting skin has been used and is recommended by the authors for the treatment of not only the thermic--, but of the mechanis lesions. The author has obtained very good results. The method is discussed and its advantages are pointed out. | [The use of "mesh graft" in traumatology]. Vandeput and J. Tanner's method for the reconstruction of the reticular grafting skin has been used and is recommended by the authors for the treatment of not only the thermic--, but of the mechanis lesions. The author has obtained very good results. The method is discussed an... | [
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PMID:6828 | [Solitary tuberculoma in the tendonous section of the m. quadriceps]. | A case of isolated tuberculosis observed in the tensinous part of the quadriceps muscle is reported by the authors. The rarity of the case is pointed out. A few possibilities of the development of this tuberculoma are dealt with. In the authors' case the focus developed probably after haematogenous generalization. One ... | [Solitary tuberculoma in the tendonous section of the m. quadriceps]. A case of isolated tuberculosis observed in the tensinous part of the quadriceps muscle is reported by the authors. The rarity of the case is pointed out. A few possibilities of the development of this tuberculoma are dealt with. In the authors' case... | [
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PMID:6829 | [The effect of chitin powder on the healing of skin wounds]. | Locally administered chitin powder has influences favourably the healing of the circular, open skin wounds on the dorsum. The tensil strength of the 7 days' incised skin wounds on the dorsum has increased under the effect of chitin powder suspension administered 3 days before the incision. The total hydroxyproline cont... | [The effect of chitin powder on the healing of skin wounds]. Locally administered chitin powder has influences favourably the healing of the circular, open skin wounds on the dorsum. The tensil strength of the 7 days' incised skin wounds on the dorsum has increased under the effect of chitin powder suspension administe... | [
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PMID:6830 | [Constitution and structure of human tendons]. | In this introductory study our actual knowledge on the tendons is resumed and it is pointed out that on the basis of this knowledge no explanation is given as regards the pathomechanism of the "spontaneous" tendon ruptures. The authors' concept on the tendons as motor units is discussed. The examinations are dealt with... | [Constitution and structure of human tendons]. In this introductory study our actual knowledge on the tendons is resumed and it is pointed out that on the basis of this knowledge no explanation is given as regards the pathomechanism of the "spontaneous" tendon ruptures. The authors' concept on the tendons as motor unit... | [
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PMID:6831 | [Incidence of blood aspiration in fatal fractures of the base of the skull]. | The frequency of blood inhalation has been examined by the authors in the 15 years' material of the Institute of Forensic Medicine of the "Semmelweis" University Medical School. Out of 51.308 post mortem examinations 487 cases of isolated basicranial fractures were found. Out of them in 265 cases (=54%) blood inhalatio... | [Incidence of blood aspiration in fatal fractures of the base of the skull]. The frequency of blood inhalation has been examined by the authors in the 15 years' material of the Institute of Forensic Medicine of the "Semmelweis" University Medical School. Out of 51.308 post mortem examinations 487 cases of isolated basi... | [
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PMID:6832 | [Open fractures of the hand joints]. | In the authors' opinion the optimal treatment of the open fractures of the hand articulations is the internal fixation offering the best fixation possible--this being the best antidote of the inflammatory complications and assuring the satisfactory late functional results. The splinting (stabliizing) methods known so f... | [Open fractures of the hand joints]. In the authors' opinion the optimal treatment of the open fractures of the hand articulations is the internal fixation offering the best fixation possible--this being the best antidote of the inflammatory complications and assuring the satisfactory late functional results. The splin... | [
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PMID:6833 | [Superficial tendoplasty after injury of the intrinsic muscle]. | In 6 fingers of two injured patients, after the lesion of the intrinsic musculature of the finger with three phalanges Bunnell's sublime tendoplasty has been performed by the authors. Satisfactory functional results have been obtained, therefore the method is recommended by the authors for the treatment of similar lesi... | [Superficial tendoplasty after injury of the intrinsic muscle]. In 6 fingers of two injured patients, after the lesion of the intrinsic musculature of the finger with three phalanges Bunnell's sublime tendoplasty has been performed by the authors. Satisfactory functional results have been obtained, therefore the method... | [
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PMID:6834 | [Experimental tendon sheath formation by free transplantation of a long vein segment (comparative study of adhesions formed around free grafts and pedicled grafts)]. | In dog experiments, in order to improve the functions after tendinous injuries diphasic operations have been performed by the authors. In the first phase, after the extirpation of the tendon of the 2nd finger its area has been bridged over by a 5-6 cm long autologous vein transplant, cannulated with a silicone rubber b... | [Experimental tendon sheath formation by free transplantation of a long vein segment (comparative study of adhesions formed around free grafts and pedicled grafts)]. In dog experiments, in order to improve the functions after tendinous injuries diphasic operations have been performed by the authors. In the first phase,... | [
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PMID:6835 | [Pig skin xenograft in burns. I. Technology, laboratory studies. II. Clinical experience]. | The technology of the preparation of certainly sterile xenograft--pig's skin has been examined by the authors before the therapeutical use. On the basis of their examinations it was found by the authors that 2500 krad gamma radiation is suitable for the sterilization of the pig's skin--for the preparation of both the n... | [Pig skin xenograft in burns. I. Technology, laboratory studies. II. Clinical experience]. The technology of the preparation of certainly sterile xenograft--pig's skin has been examined by the authors before the therapeutical use. On the basis of their examinations it was found by the authors that 2500 krad gamma radia... | [
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PMID:6836 | [Radioisotopes used in the diagnosis of bone diseases]. | The radiopharmacons produced in Hungary and suitable for the demonstration of reactive bone alterations are discussed by the authors. These pharmacons are the following: 85ScCl2=Strontiumchloride, 153Sm-EDTA=Samarium ethylendiamintetraacetate, 169Yb-citrate=Ytterbium-citrate, 99mTc-HEDSPA=Technetium-hydroxy-ethylene-di... | [Radioisotopes used in the diagnosis of bone diseases]. The radiopharmacons produced in Hungary and suitable for the demonstration of reactive bone alterations are discussed by the authors. These pharmacons are the following: 85ScCl2=Strontiumchloride, 153Sm-EDTA=Samarium ethylendiamintetraacetate, 169Yb-citrate=Ytterb... | [
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PMID:6838 | [Surgical treatment of knee joint ligaments]. | Because injuries of the ligaments of the knee joint, during 11 years 58 operations have been performed by the authors. In order to evaluate the late results, all patients have been reexamined 1 to 10 years after the operation. In more than the half of the cases at the least 2 ligament injuries have been operated on. 31... | [Surgical treatment of knee joint ligaments]. Because injuries of the ligaments of the knee joint, during 11 years 58 operations have been performed by the authors. In order to evaluate the late results, all patients have been reexamined 1 to 10 years after the operation. In more than the half of the cases at the least... | [
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PMID:6839 | [The so-called "intact" side in Perthes' disease]. | Out of the 32 patients treated with Perthes' disease in the Orthopaedic Department of the University Medical School, PECS, in 9 cases bilateral course has been observed. Out of 23 children with Perthes' disease and unilateral, typical course the authors have observed in 12 patients pathological X-ray signs on the "inta... | [The so-called "intact" side in Perthes' disease]. Out of the 32 patients treated with Perthes' disease in the Orthopaedic Department of the University Medical School, PECS, in 9 cases bilateral course has been observed. Out of 23 children with Perthes' disease and unilateral, typical course the authors have observed i... | [
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PMID:6840 | [Alloplastic reconstruction of the proximal third of the femur. Case report]. | The case of a woman, aged 51, is reported. In this patient, in 1961, because of an alteration developed in the right neck of the femur--and trochanter area--diagnosed for osteoclastoma--irradiation treatment has been performed. After steadily increasing complaints the patient suffered in 1965 a pathological fracture. I... | [Alloplastic reconstruction of the proximal third of the femur. Case report]. The case of a woman, aged 51, is reported. In this patient, in 1961, because of an alteration developed in the right neck of the femur--and trochanter area--diagnosed for osteoclastoma--irradiation treatment has been performed. After steadily... | [
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PMID:6841 | Program for managing chronic pain. II. Short-term results. | A program for treating inpatients who had chronic pain resulted in significant improvement in 79% of them by the time of their dismissal. At the time of short-term follow-up (6 months), however, this improvement rate had diminished to 50%. It was observed that this type of chronically disabled person can return home an... | Program for managing chronic pain. II. Short-term results. A program for treating inpatients who had chronic pain resulted in significant improvement in 79% of them by the time of their dismissal. At the time of short-term follow-up (6 months), however, this improvement rate had diminished to 50%. It was observed that ... | [
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PMID:6856 | Enzymatic hydrolysis of 1-monoacyl-SN-glycerol-3-phosphoryl-choline (1-lysolecithin) by phospholipases from peanut seeds. | Hydrolysis of 1-lysolecithin (1-acyl glycerophosphorylcholine [1-acyl GPC]) by preparations of phospholipase D from peanut seeds was investigated. 1-Lysolecithin was hydrolyzed at a much slower rate than phosphatidylcholine (lecithin). Although Ca+2 ions are required for the cleavage of lecithin by the enzyme, their ef... | Enzymatic hydrolysis of 1-monoacyl-SN-glycerol-3-phosphoryl-choline (1-lysolecithin) by phospholipases from peanut seeds. Hydrolysis of 1-lysolecithin (1-acyl glycerophosphorylcholine [1-acyl GPC]) by preparations of phospholipase D from peanut seeds was investigated. 1-Lysolecithin was hydrolyzed at a much slower rate... | [
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PMID:6857 | The potentialities of some antihistaminics in preanaesthetic medication. | A detailed study has been carried out on the potentialities of antazoline and chlorpheneramine (C.P.M.) in preanaesthetic medication. It included a determination of their sedative action, effects on cardiovascular system and any possible anticholinergic and antiarrhythmic properties. Both drugs depressed spontaneous ac... | The potentialities of some antihistaminics in preanaesthetic medication. A detailed study has been carried out on the potentialities of antazoline and chlorpheneramine (C.P.M.) in preanaesthetic medication. It included a determination of their sedative action, effects on cardiovascular system and any possible anticholi... | [
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PMID:6862 | [Classification of acute bacterial meningitis cases according to their etiology, seen in a children's hospital in Ankara from March 1973 to April 1974]. | In a 14 months period, as from March 1973 to April 1974 468 cases of acute bacterial meningitis have been diagnosed by C.S.F. findings; namely by examining the protein and sugar content, by the cell counts, Gram's staining and culturing of the sediments of C.S.F. 188 cases were proven by culturing to be meningococcic m... | [Classification of acute bacterial meningitis cases according to their etiology, seen in a children's hospital in Ankara from March 1973 to April 1974]. In a 14 months period, as from March 1973 to April 1974 468 cases of acute bacterial meningitis have been diagnosed by C.S.F. findings; namely by examining the protein... | [
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PMID:6860 | [Yeast cell wall-dissolving enzymes of the thermotolerant actinomycete Thermoactinomyces vulgaris]. | The thermotolerant culture of Thermoactinomyces vulgaris PA II-4A was cultivated in the Biotec fermenter to obtain the enzyme preparation with a high proteolytic and lytic activity. Resistance of the cells of Candida utilis and Saccharomyces fragilis (mesophilic and thermotolerant strains) to the lytic action of the en... | [Yeast cell wall-dissolving enzymes of the thermotolerant actinomycete Thermoactinomyces vulgaris]. The thermotolerant culture of Thermoactinomyces vulgaris PA II-4A was cultivated in the Biotec fermenter to obtain the enzyme preparation with a high proteolytic and lytic activity. Resistance of the cells of Candida uti... | [
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PMID:6861 | [Cholesterol breakdown by enzyme preparations extracted from Streptomyces lavendulae]. | Cholesterol was decomposed by 75-90% during two hours by enzyme preparations from the disintegrated mycelium of Streptomyces lavendulae. The effect of concentrations of cholesterol and protein on the decomposition of cholesterol by the enzyme was studied; the higher the content of protein in a sample, the more rapidly ... | [Cholesterol breakdown by enzyme preparations extracted from Streptomyces lavendulae]. Cholesterol was decomposed by 75-90% during two hours by enzyme preparations from the disintegrated mycelium of Streptomyces lavendulae. The effect of concentrations of cholesterol and protein on the decomposition of cholesterol by t... | [
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PMID:6865 | Sulphasalazine lung. | A patient developed the rare complication of pulmonary eosinophilia whilst receiving sulphasalazine. A review of the world literature on sulphasalazine-induced lung disease is presented. | Sulphasalazine lung. A patient developed the rare complication of pulmonary eosinophilia whilst receiving sulphasalazine. A review of the world literature on sulphasalazine-induced lung disease is presented. | [
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PMID:6863 | A tentative transmission mechanism for the twitch elicited in guinea-pig vas deferens by field stimulation. | The twitch response to nerve activity in the vas deferens does not behave as if it were adrenergic since it is enhanced by adrenoceptor blockers and often inhibited by noradrenaline and other sympathomimieic amines. Potassium (K+) ions have a strong reinforcing action on the twitch and easily restore it after blockade ... | A tentative transmission mechanism for the twitch elicited in guinea-pig vas deferens by field stimulation. The twitch response to nerve activity in the vas deferens does not behave as if it were adrenergic since it is enhanced by adrenoceptor blockers and often inhibited by noradrenaline and other sympathomimieic amin... | [
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PMID:6867 | [On the significance of beta-adrenergic stimuli for the gastric secretion in humans]. | In adults of both sexes, the influence on the basal and the maximal by means of pentagastrin stimulated gastric secretion of a single intravenous injection of 8 mg (0.09 to 0.16 mg/kg) oxyfedrine or of two intramuscular injections of 1 mg (0.014 to 0.016 mg/kg) or of 2.5 mg (0.033 to 0.045 mg/kg) in each case isoproter... | [On the significance of beta-adrenergic stimuli for the gastric secretion in humans]. In adults of both sexes, the influence on the basal and the maximal by means of pentagastrin stimulated gastric secretion of a single intravenous injection of 8 mg (0.09 to 0.16 mg/kg) oxyfedrine or of two intramuscular injections of ... | [
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PMID:6900 | [Beta-lactoglobulin AB fluorescence under different physico-chemical conditions. Denaturation by urea and organic solvents]. | Dependences of different fluorescence parameters of bovine beta-lactoglobulin AB on the concentrations of urea (pH 2.8-8.8), ethanol (pH 2.1-10.2), and dioxane (pH 5.3) have been investigated. The denaturation properties (the free energy and the stoichiometry of denaturative interaction) are highly dependent on pH valu... | [Beta-lactoglobulin AB fluorescence under different physico-chemical conditions. Denaturation by urea and organic solvents]. Dependences of different fluorescence parameters of bovine beta-lactoglobulin AB on the concentrations of urea (pH 2.8-8.8), ethanol (pH 2.1-10.2), and dioxane (pH 5.3) have been investigated. Th... | [
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PMID:6901 | [The compact form of DNA in solution. IV. The effect of secondary structure defectiveness on the arrangement of double-chained DNA molecules into compact particles]. | Influence of pH on absorbance and CD-spectra of DNA in PEG-containing water-salt solutions has been studied. The changes in the spectra appeared due to disturbance of the DNA secondary structure upon acidification of the medium proir to or after DNA compactization. If acidification preceeds DNA compactization an intens... | [The compact form of DNA in solution. IV. The effect of secondary structure defectiveness on the arrangement of double-chained DNA molecules into compact particles]. Influence of pH on absorbance and CD-spectra of DNA in PEG-containing water-salt solutions has been studied. The changes in the spectra appeared due to di... | [
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PMID:6902 | [Kinetics and mechanism of inactivation of isolated chloroplasts]. | A detailed kinetic analysis has been performed of a multistep inactivation of chloroplasts. The kinetic model suggested involves the formation of chloroplast forms differing in stability and activity. A comparison of the kinetic model with the experimental data shows that the mechanism of inactivation of isolated pea c... | [Kinetics and mechanism of inactivation of isolated chloroplasts]. A detailed kinetic analysis has been performed of a multistep inactivation of chloroplasts. The kinetic model suggested involves the formation of chloroplast forms differing in stability and activity. A comparison of the kinetic model with the experimen... | [
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PMID:6909 | Methylmalonic aciduria without vitamin B12 deficiency in an adult sibship. | Two brothers 62 and 70 years old, without evidence of vitamin B12 lack, excreted 12 to 115 mg of methylmalonic acid daily (normal, less than 9 mg per day). Neither had anemia or hepatic dysfunction, and serum vitamin B12 concentrations ranged from 369 to 800 pg per milliliter. The propositus, the younger brother, conti... | Methylmalonic aciduria without vitamin B12 deficiency in an adult sibship. Two brothers 62 and 70 years old, without evidence of vitamin B12 lack, excreted 12 to 115 mg of methylmalonic acid daily (normal, less than 9 mg per day). Neither had anemia or hepatic dysfunction, and serum vitamin B12 concentrations ranged fr... | [
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PMID:6918 | Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents. | The influence of clonidine on alpha-adrenoreceptors in the central nervous system of rats and mice has been investigated. Both functional events due to postsynaptic receptor stimulation (flexor reflex activity, motor activity) and biochemical changes have been considered. 1. Clonidine was less potent in stimulating the... | Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents. The influence of clonidine on alpha-adrenoreceptors in the central nervous system of rats and mice has been investigated. Both functional events due to postsynaptic recep... | [
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PMID:6919 | Noradrenaline synthesis and utilization: control by nerve impulse flow under normal conditions and after treatment with alpha-adrenoreceptor blocking agents. | The changes in the synthesis and utilization or noradrenaline cranial and caudal to an acute section of the rat spinal cord have been used to investigate the importance of nerve impulses for these processes. 1. Cranial to a lesion of the spinal cord, the alpha-methyltyrosine-induced disappearance of noradrenaline was a... | Noradrenaline synthesis and utilization: control by nerve impulse flow under normal conditions and after treatment with alpha-adrenoreceptor blocking agents. The changes in the synthesis and utilization or noradrenaline cranial and caudal to an acute section of the rat spinal cord have been used to investigate the impo... | [
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PMID:6925 | [Takayasu-Onishi arteritis. II. Relations of Takayasu-Onishi arteritis with other non-specific arteritides]. | Takayasu-Onishi arteritis (T.O.) is similar to Hutchison-Horton arteritis (H.H.) on histological, clinical, laboratory, and pathogenetic grounds. Both probably depend on immunitary dysreactivity, their different clinical expression being attributable to differences in the district involved and the age of the subject. B... | [Takayasu-Onishi arteritis. II. Relations of Takayasu-Onishi arteritis with other non-specific arteritides]. Takayasu-Onishi arteritis (T.O.) is similar to Hutchison-Horton arteritis (H.H.) on histological, clinical, laboratory, and pathogenetic grounds. Both probably depend on immunitary dysreactivity, their different... | [
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PMID:6924 | [Takayasu-Onishi arteritis. Current etiopathogenetic aspects]. | By Takayasu-Onishi's arteritis is meant an arteritic process with unknown aetiology which electively affects young women, seemingly of prevalently Asiatic stock. The disease concerns almost exclusively large elastic arteries and presents clinically with early preocclusive symptomatology followed, after a varying period... | [Takayasu-Onishi arteritis. Current etiopathogenetic aspects]. By Takayasu-Onishi's arteritis is meant an arteritic process with unknown aetiology which electively affects young women, seemingly of prevalently Asiatic stock. The disease concerns almost exclusively large elastic arteries and presents clinically with ear... | [
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PMID:6926 | [Comparative evaluation of local 02 consumption in lumbar sympathetic infiltration as compared with acupuncture]. | The effectiveness of acupuncture in the treatment of lower limb obliterating arteritis as an alternative to pharmacological sympatheticolumbar block was assessed by comparing local O2 consumption in the ischaemic extremity. It was found that both techniques lead to vasodilation sufficient to normalise local values. Acu... | [Comparative evaluation of local 02 consumption in lumbar sympathetic infiltration as compared with acupuncture]. The effectiveness of acupuncture in the treatment of lower limb obliterating arteritis as an alternative to pharmacological sympatheticolumbar block was assessed by comparing local O2 consumption in the isc... | [
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PMID:6927 | A survey of isolates of Streptococcus pneumoniae. | Over eight months 130 isolates of Streptococcus pneumoniae were examined for sensitivity to penicillin, tetracycline, cephalosporin and co-trimoxozole. Except in one doubtful case all isolates were sensitive to penicillin. All were sensitive to cephalosporin. 6.9 percent is isolates were resistant to co-trimoxozole. It... | A survey of isolates of Streptococcus pneumoniae. Over eight months 130 isolates of Streptococcus pneumoniae were examined for sensitivity to penicillin, tetracycline, cephalosporin and co-trimoxozole. Except in one doubtful case all isolates were sensitive to penicillin. All were sensitive to cephalosporin. 6.9 percen... | [
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PMID:6929 | [Acute hepatic porphyria as diagnostic problem in childhood (author's transl)]. | Case report of a 12 year old girl with acute hepatic porphyria. The difficulties of diagnosis in childhood are discussed. No effective treatment is known. The importance of early diagnosis is emphasized, in order to avoid certain medicaments, stress situations etc., which can cause an acute attack of porphyria. | [Acute hepatic porphyria as diagnostic problem in childhood (author's transl)]. Case report of a 12 year old girl with acute hepatic porphyria. The difficulties of diagnosis in childhood are discussed. No effective treatment is known. The importance of early diagnosis is emphasized, in order to avoid certain medicament... | [
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PMID:6928 | Dibenzepin and amitriptyline in depressive states: comparative double-blind trial. | Dibenzepin and amitriptyline appeared to be equally efficacious in controlling target symptoms of depressive reactions. These results appear to be consistent with pharmacological profiles of the two drugs which are both tricylic compounds. Control of target symptoms occurred in an undulating and non-progressive manner ... | Dibenzepin and amitriptyline in depressive states: comparative double-blind trial. Dibenzepin and amitriptyline appeared to be equally efficacious in controlling target symptoms of depressive reactions. These results appear to be consistent with pharmacological profiles of the two drugs which are both tricylic compound... | [
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PMID:6940 | Acid-base curve nomogram for dog blood. | Pooled canine blood of different hemoglobin concentration was equilibrated with two carbon dioxide tensions and the resulting pH's of the samples were measured at 38 degrees C. Readings obtained provided data for the construction of a cartesian nomogram for the dog, based on the pH/log pCO2 coordinate system. The nomog... | Acid-base curve nomogram for dog blood. Pooled canine blood of different hemoglobin concentration was equilibrated with two carbon dioxide tensions and the resulting pH's of the samples were measured at 38 degrees C. Readings obtained provided data for the construction of a cartesian nomogram for the dog, based on the ... | [
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PMID:6950 | The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala. | The influence of electrical and chemical stimulation of nucleus caudatus (NC) on bioelectrical seizure activity of amygdala (Am) was studied in rabbits. The electrical stimulation of NC inhibits seizures in Am induced by the administration of picrotoxin into this nucleus. Dopamine (DA) and cholinomimetics-metacholine a... | The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala. The influence of electrical and chemical stimulation of nucleus caudatus (NC) on bioelectrical seizure activity of amygdala (Am) was studied in rabbits. The electrical stimulation of NC inhibits seizures in Am ... | [
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PMID:6952 | Changes in plasma electrolytes, acid-base balance and other physiological parameters of adult female turkeys under conditions of acute hyperthermia. | The effects of acute hyperthermia on certain physiological parameters of turkey hens was studied. It was found that the response of the turkey to hyperthermia is similar to the reported response of the chicken. The birds began panting and the average body temperature increased 0.1 degrees C. as the ambient temperature ... | Changes in plasma electrolytes, acid-base balance and other physiological parameters of adult female turkeys under conditions of acute hyperthermia. The effects of acute hyperthermia on certain physiological parameters of turkey hens was studied. It was found that the response of the turkey to hyperthermia is similar t... | [
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PMID:6953 | Acid-base balance, plasma electrolytes and production performance of adult turkey hens under conditions of increasing ambient temperature. | Turkey hens were exposed to stepwise increases in ambient temperature from 21 degrees C. to 25 degrees C. to 30 degrees C. to 35 degrees C. at two-week intervals. Dietary calcium levels to 1.54, 2.01 and 2.48 percent were fed. Acid-base balance, plasma electrolytes and production performance were studied. The temperatu... | Acid-base balance, plasma electrolytes and production performance of adult turkey hens under conditions of increasing ambient temperature. Turkey hens were exposed to stepwise increases in ambient temperature from 21 degrees C. to 25 degrees C. to 30 degrees C. to 35 degrees C. at two-week intervals. Dietary calcium le... | [
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PMID:6958 | beta-Adrenergic blockade reduces the severity of acute renal failure in rats. | Propranolol administration in the hypoxic model of acute renal failure (ARF) in rats has reduced plasma renin activity (PRA) and uraemia as compared to untreated controls. P113 has no effect on uraemia but increased PRA in ARF. A combination of both drugs is no more effective in reducing uraemia than propranolol alone.... | beta-Adrenergic blockade reduces the severity of acute renal failure in rats. Propranolol administration in the hypoxic model of acute renal failure (ARF) in rats has reduced plasma renin activity (PRA) and uraemia as compared to untreated controls. P113 has no effect on uraemia but increased PRA in ARF. A combination ... | [
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PMID:6954 | [The effect of ACTH and several antimetabolites of vitamin B6 on the activity of tyrosine aminotransferase in the liver of intact and hypophysectomized rats]. | ACTH injected intraperitoneally in a dose of 140 Units per 1 kg of body weight to intact rats or to rats subjected to hypophysectomy 24 hours before the experiment produced an increase in the activity of tyrosine-aminotrasferase in the liver (4.5 or 2.5 times, respectively) in comparison with the normal. D-cycloserine ... | [The effect of ACTH and several antimetabolites of vitamin B6 on the activity of tyrosine aminotransferase in the liver of intact and hypophysectomized rats]. ACTH injected intraperitoneally in a dose of 140 Units per 1 kg of body weight to intact rats or to rats subjected to hypophysectomy 24 hours before the experime... | [
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PMID:6959 | Acute renal effects of new beta-adrenergic receptor site blocking agents on renal function. | The effects of two new beta blockers on renal function have been studied. There were significant decreases in urine flow, urea clearance, sodium and chloride excretion rates after acute administration. Fractional excretion of sodium (FeNa) fell significantly but did not continue to fall during chronic administration. B... | Acute renal effects of new beta-adrenergic receptor site blocking agents on renal function. The effects of two new beta blockers on renal function have been studied. There were significant decreases in urine flow, urea clearance, sodium and chloride excretion rates after acute administration. Fractional excretion of so... | [
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PMID:6960 | Interrelationships between Ca2+ and adenylate and guanylate cyclases in the control of platelet secretion and aggregation. | Ca2+ is a powerful inhibitor (Ki is congruent to 16 muM) of basal and prostaglandin E1 (PGE1)-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1] activity in membranes obtained from homogenized human platelets. Ca2+ (but not the ionophore A23,187) decreased V(max) of the reaction without an e... | Interrelationships between Ca2+ and adenylate and guanylate cyclases in the control of platelet secretion and aggregation. Ca2+ is a powerful inhibitor (Ki is congruent to 16 muM) of basal and prostaglandin E1 (PGE1)-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1] activity in membranes ob... | [
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PMID:6961 | The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles. | Membrane vesicles isolated from E. coli generate a trans-membrane proton gradient of 2 pH units under appropriate conditions when assayed by flow dialysis. Using the distribution of weak acids to measure the proton gradient (deltapH) and the distribution of the lipophilic cation triphenyl-methylphosphonium to measure t... | The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles. Membrane vesicles isolated from E. coli generate a trans-membrane proton gradient of 2 pH units under appropriate conditions when assayed by flow dialysis. Using the distribution of weak acids to meas... | [
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0.0... |
PMID:6962 | Observation of individual carboxyl groups in hen egg-white lysozyme by use of high field 13C-nuclear magnetic resonance. | Several of the carboxyl carbon atom resonances of hen egg-white lysozyme (mucopeptide N-acetylmuramoyl hydrolase, EC 3.2.1.17) have been resolved by 13C-nuclear magnetic resonance (NMR) at 68 MHz. The change in chemical shift of the carboxyl carbon atom resonances, as a function of pH, has enabled the distinction of th... | Observation of individual carboxyl groups in hen egg-white lysozyme by use of high field 13C-nuclear magnetic resonance. Several of the carboxyl carbon atom resonances of hen egg-white lysozyme (mucopeptide N-acetylmuramoyl hydrolase, EC 3.2.1.17) have been resolved by 13C-nuclear magnetic resonance (NMR) at 68 MHz. Th... | [
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0.0... |
PMID:6963 | Markedly elevated angiotensin converting enzyme in lymph nodes containing non-necrotizing granulomas in sarcoidosis. | Sarcoidosis is a disease of unknown etiology that is characterized by the generalized formation of granulomas and is accompanied by elevation in the serum in less than half the patients of angiotensin converting enzyme, a dipeptidyl carboxypeptidase that catalyzes the conversion of the decapeptide, angiotensin I, to th... | Markedly elevated angiotensin converting enzyme in lymph nodes containing non-necrotizing granulomas in sarcoidosis. Sarcoidosis is a disease of unknown etiology that is characterized by the generalized formation of granulomas and is accompanied by elevation in the serum in less than half the patients of angiotensin co... | [
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0.... |
PMID:6970 | Nucleation of microbiologic calcification by proteolipid. | The component of crude phospholipid responsible for B. matruchotii calcification was isolated. Crude phospholipid, extracted from the microorganism, was separated into five fractions by column chromatography. A single, protein-containing fraction catalyzed apatite formation in a metastable calcium phosphate solution. T... | Nucleation of microbiologic calcification by proteolipid. The component of crude phospholipid responsible for B. matruchotii calcification was isolated. Crude phospholipid, extracted from the microorganism, was separated into five fractions by column chromatography. A single, protein-containing fraction catalyzed apati... | [
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0.012982716783881187,
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0.04741181805729866,
... |
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