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PMID:7919 | The effect of adrenergic blocking and stimulating agents on arginine vasotocin release in birds. | The effect of adrenergic blocking and stimulating agents on arginine vasotocin (AVT) release from the neurohpophysis following osmotic stimuli was studied in hens. It was found that alpha - adrenergic blocking drug - regitine inhibits the release of AVT after the intravenous injection of hypertonic solution of NaCl. Th... | The effect of adrenergic blocking and stimulating agents on arginine vasotocin release in birds. The effect of adrenergic blocking and stimulating agents on arginine vasotocin (AVT) release from the neurohpophysis following osmotic stimuli was studied in hens. It was found that alpha - adrenergic blocking drug - regiti... | [
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PMID:7920 | Studies on the activity of cholinesterase included on silica gel. | Cholinesterase was immobilized in silica gel. The activity of the bound enzyme was determined by comparing the concentrations of hydrogen ions in the solution entering and leaving the reactor, filled with a suspension of the insoluble enzyme in Sephadex. | Studies on the activity of cholinesterase included on silica gel. Cholinesterase was immobilized in silica gel. The activity of the bound enzyme was determined by comparing the concentrations of hydrogen ions in the solution entering and leaving the reactor, filled with a suspension of the insoluble enzyme in Sephadex. | [
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PMID:7926 | Amino acid transport in isolated neurons and glia. | Our efforts have been directed towards characterizing amino acid uptake, metabolism and release in bulk-isolated glia and neuronal perikarya studied in parallel with nerve-endings, especially as it concerns the transmitter amino acids and the participation of glia in the clearing of the synpatic space during impulse co... | Amino acid transport in isolated neurons and glia. Our efforts have been directed towards characterizing amino acid uptake, metabolism and release in bulk-isolated glia and neuronal perikarya studied in parallel with nerve-endings, especially as it concerns the transmitter amino acids and the participation of glia in t... | [
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PMID:7933 | Mediation of macrophage effector function by lymphokine. | The progressive effect of lymphokine contact on macrophages in vitro has been studied using various quantitative cytochemical techniques. Changes in the physiology of the macrophages have been seen rapidly after lymphokine contact. These appear to correlate with the functional effect of inhibition of migration. After m... | Mediation of macrophage effector function by lymphokine. The progressive effect of lymphokine contact on macrophages in vitro has been studied using various quantitative cytochemical techniques. Changes in the physiology of the macrophages have been seen rapidly after lymphokine contact. These appear to correlate with ... | [
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PMID:7934 | Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: evidence for the importance of pharmacokinetics. | A variety of acidic and non-acidic compounds are potent inhibitors of prostaglandin (PG) synthesis in vitro. However, only a few, namely the acidic nonsteroid anti-inflammatory drugs (NSAID) are useful anti-inflammatory analgesics in the clinic. Since inhibition of PG-synthesis is believed to be the main target of NSAI... | Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: evidence for the importance of pharmacokinetics. A variety of acidic and non-acidic compounds are potent inhibitors of prostaglandin (PG) synthesis in vitro. However, only a few, namely the acidic nonsteroid anti-inflammatory drugs (NS... | [
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PMID:7935 | Electrophoretic separation and characterization of subunits released from influenza virus by detergents. | Subunits released from influenza A/Singapore/1/57 (H2N2) virus by either Triton-X-100 (T-X-100); or sodium lauryl sarcosinate (SLS) or ether were separated by electrophoresis in agarose suspension into a rapidly migrating fraction (I) and a slowly migrating fraction (II). Fraction I obtained after T-X-100 treatment con... | Electrophoretic separation and characterization of subunits released from influenza virus by detergents. Subunits released from influenza A/Singapore/1/57 (H2N2) virus by either Triton-X-100 (T-X-100); or sodium lauryl sarcosinate (SLS) or ether were separated by electrophoresis in agarose suspension into a rapidly mig... | [
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PMID:7936 | The effect of combination of different inducers on the refractory state in interferon production. | A second injection of 100 mug poly (rI) poly (rC) per mouse at 6 and 24 hours after the first injection stimulated additional peaks of interferon production. The dynamics of the process of accumulation and disappearance of interferon was similar to that after a single injection of poly (rI). poly (rC). Injection of the... | The effect of combination of different inducers on the refractory state in interferon production. A second injection of 100 mug poly (rI) poly (rC) per mouse at 6 and 24 hours after the first injection stimulated additional peaks of interferon production. The dynamics of the process of accumulation and disappearance of... | [
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PMID:7937 | The dynamics of development of cell resistance to viruses induced by synthetic polynucleotides. | The dynamics of interaction of complexes of synthetic polynucleotides (polyinosinic and polycitidylic acid--poly (rI)-poly (rC), and polyguanylic and polycytidylic acid--poly (rG)-poly (rC)) with cells as well as the dynamics of interferon accumulation and development of antiviral effect against some RNA viruses were s... | The dynamics of development of cell resistance to viruses induced by synthetic polynucleotides. The dynamics of interaction of complexes of synthetic polynucleotides (polyinosinic and polycitidylic acid--poly (rI)-poly (rC), and polyguanylic and polycytidylic acid--poly (rG)-poly (rC)) with cells as well as the dynamic... | [
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PMID:7938 | Biochemical classification of herpes simplex virus types 1 and 2, and of intermediate strains on the basis of different susceptibilities of thymidine kinase to thymidine analogues. | Herpes simplex virus (HSV) type 1 can be differentiated from HSV type 2 on the basis of the sensitivity to 2'-deoxythymidine-5'-monophosphate of thymidine kinase induced in primary rabbit kidney cells. Whereas thymidine kinase induced by five strains of HSV type 1 (TK 1) is stimulated by suitable concentrations of 2'-d... | Biochemical classification of herpes simplex virus types 1 and 2, and of intermediate strains on the basis of different susceptibilities of thymidine kinase to thymidine analogues. Herpes simplex virus (HSV) type 1 can be differentiated from HSV type 2 on the basis of the sensitivity to 2'-deoxythymidine-5'-monophospha... | [
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PMID:7939 | Persistent infection of BHK cells with herpes simplex virus types 1 and 2 in the absence of specific anti-herpetic antibody. | Persistent infection of BHK-21 cells with 5 strains of herpes simplex virus (HSV) type 1 and a 1 strain of HSV type 2 is described. Acute infection only was obtained with two strains of type 1 and one strain of type 2. Persistent infection could not be established in HeLa and rabbit lung cells. Persistent infection of ... | Persistent infection of BHK cells with herpes simplex virus types 1 and 2 in the absence of specific anti-herpetic antibody. Persistent infection of BHK-21 cells with 5 strains of herpes simplex virus (HSV) type 1 and a 1 strain of HSV type 2 is described. Acute infection only was obtained with two strains of type 1 an... | [
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PMID:7940 | Reactions of immune sera against the nucleocapsid, envelope and whole herpes simplex virus type 1. | Antibodies against (a) naked particles, (b) virus envelope, and (c) whole herpes simplex virus (HSV) type 1 were investigated. Immune rabbit serum against naked particles (and formalized naked particles) contained virus neutralizing (VN) antibody in a low titre as compared to the titre of complement-fixing (CF) antibod... | Reactions of immune sera against the nucleocapsid, envelope and whole herpes simplex virus type 1. Antibodies against (a) naked particles, (b) virus envelope, and (c) whole herpes simplex virus (HSV) type 1 were investigated. Immune rabbit serum against naked particles (and formalized naked particles) contained virus n... | [
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PMID:7941 | Gel chromatography of serum from mice infected with a virus elevating L-lactate: NAD oxidoreductase activity--an attempt to separate viral and enzymatic activities. | Gel chromatography on Spheron P-500 of mouse serum yielded fractions elevating lactate dehydrogenase activity. The order of elution was viral activity, proteins and lactate dehydrogenase activity. Viral contamination occurred also in certain fractions subjected to repeated gel chromatography in which no proteins were d... | Gel chromatography of serum from mice infected with a virus elevating L-lactate: NAD oxidoreductase activity--an attempt to separate viral and enzymatic activities. Gel chromatography on Spheron P-500 of mouse serum yielded fractions elevating lactate dehydrogenase activity. The order of elution was viral activity, pro... | [
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PMID:7942 | Further experiments on the action of antithymocyte serum in experimental Junín virus infection. | Rabbit anti-mouse thymocyte serum (ATS) administrated as late as 7 days after infection suppressed host cell-mediated responsiveness to intracerebrally injected Junín virus, thereby diminishing the morbility and mortality of this infection. It did not affect either the humoral antibody response or the virus titer in br... | Further experiments on the action of antithymocyte serum in experimental Junín virus infection. Rabbit anti-mouse thymocyte serum (ATS) administrated as late as 7 days after infection suppressed host cell-mediated responsiveness to intracerebrally injected Junín virus, thereby diminishing the morbility and mortality of... | [
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PMID:7943 | The value of complement fixation and haemagglutination inhibition tests in the diagnosis of influenza A. | Antibody response of 133 influenza A patients from three outbreaks since 1972-73 was analyzed by complement fixation (CF) and haemagglutination inhibition (HI) methods. During the first outbreak, a significant response was more often measured by CF than by HI. During the last outbreak HI appeared more useful than CF fo... | The value of complement fixation and haemagglutination inhibition tests in the diagnosis of influenza A. Antibody response of 133 influenza A patients from three outbreaks since 1972-73 was analyzed by complement fixation (CF) and haemagglutination inhibition (HI) methods. During the first outbreak, a significant respo... | [
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PMID:7944 | Susceptibility of various cell lines to virulent and attenuated strains of pseudorabies virus. | Various cell lines were infected with virulent and attenuated strains of pseudorabies virus (PRV). According to the type of the cytopathic effect (CPE), the cells could be divided into 3 groups: cells in which all strains formed syncytia; cells in which all strains caused rounding of cells; and cells in which virulent ... | Susceptibility of various cell lines to virulent and attenuated strains of pseudorabies virus. Various cell lines were infected with virulent and attenuated strains of pseudorabies virus (PRV). According to the type of the cytopathic effect (CPE), the cells could be divided into 3 groups: cells in which all strains for... | [
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PMID:7946 | Incidence of arbovirus antibodies in bovine, ovine and human sera collected in Eastern Sicily. | The incidence of antibodies against 9 arboviruses in ovine, bovine and human sera collected in Eastern Sicily was studied. A high incidence of antibodies was found especially against Bhanja virus in all sera and against Sandfly fever Sicilian in ovine sera only. The incidence was higher than that reported in 1971 for t... | Incidence of arbovirus antibodies in bovine, ovine and human sera collected in Eastern Sicily. The incidence of antibodies against 9 arboviruses in ovine, bovine and human sera collected in Eastern Sicily was studied. A high incidence of antibodies was found especially against Bhanja virus in all sera and against Sandf... | [
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PMID:7947 | "White-wild" (variola-like) poxvirus strains from rodents in Equatorial Africa. | Strains of variola-like virus were isolated from rodents, namely 1 each from Mastomys coucha (fam. Muridae) and Helioscorus rufobrachium (fam. Sciuridae) in the Bumba zone of the Equatorial province of the Zaire Republic. Attempts to isolate the virus from 48 monkeys were negative. Neutralizing antibodies were found in... | "White-wild" (variola-like) poxvirus strains from rodents in Equatorial Africa. Strains of variola-like virus were isolated from rodents, namely 1 each from Mastomys coucha (fam. Muridae) and Helioscorus rufobrachium (fam. Sciuridae) in the Bumba zone of the Equatorial province of the Zaire Republic. Attempts to isolat... | [
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PMID:7948 | Variable response of normal and transformed mouse cells to interferon inducers. | Balb/3T3 mouse cells, normal and SV40-transformed, produced interferon when induced with Newcastle disease and influenza viruses; transformed cells failed to respond to double-stranded RNA inducers. | Variable response of normal and transformed mouse cells to interferon inducers. Balb/3T3 mouse cells, normal and SV40-transformed, produced interferon when induced with Newcastle disease and influenza viruses; transformed cells failed to respond to double-stranded RNA inducers. | [
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PMID:7949 | Consumption of complement in chelated and nonchelated guinea pig serum after challenge with some viral and nonviral interferon inducers. | The consumption of complement observed during the induction of interferon by various inducers may proceed via the alternate pathway. The alternate pathway requires the presence of Mg ions in the medium while Ca ions may be absent. | Consumption of complement in chelated and nonchelated guinea pig serum after challenge with some viral and nonviral interferon inducers. The consumption of complement observed during the induction of interferon by various inducers may proceed via the alternate pathway. The alternate pathway requires the presence of Mg ... | [
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PMID:7951 | The dynamics of production and the sensitivity to cycloheximide and actinomycin D of interferon-inducing and interferon messenger RNA. | In the process of virus-induced interferon production, two kinds of RNA appear in the cells. One of them induces production by the recipient cells of interferon with the species-specificity of the latter cells (interferon-inducing RNA), and the other is translated by the recipient cells pre-treated with actinomycin D i... | The dynamics of production and the sensitivity to cycloheximide and actinomycin D of interferon-inducing and interferon messenger RNA. In the process of virus-induced interferon production, two kinds of RNA appear in the cells. One of them induces production by the recipient cells of interferon with the species-specifi... | [
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PMID:7952 | Efficacy of cardioselective beta adrenergic blockade with intravenously administered tolamolol in the treatment of cardiac arrhythmias. | The efficacy of tolamolol, a cardioselective beta adrenergic blocking agent, was evaluated in the treatment of cardiac arrhythmias in 27 patients. Nineteen patients had supraventricular arrhythmias and eight had ventricular arrhythmias. Evaluation was by doulbe-blind randomized trial in 23 patients. Tolamolol was effec... | Efficacy of cardioselective beta adrenergic blockade with intravenously administered tolamolol in the treatment of cardiac arrhythmias. The efficacy of tolamolol, a cardioselective beta adrenergic blocking agent, was evaluated in the treatment of cardiac arrhythmias in 27 patients. Nineteen patients had supraventricula... | [
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PMID:7953 | Ultrastructural changes of the canine gastric mucosa after topical application of graded concentrations of ethanol. | Changes in the fine structure of the gastric mucosa following exposure to graded concentrations of ethanol were studied in dogs. 300 ml of 12.5, 20, and 40%, vol/vol, were instilled intragastrically for 30 min. Mucosa from the midbody and midantrum along the greater curvature was examined by light and electron microsco... | Ultrastructural changes of the canine gastric mucosa after topical application of graded concentrations of ethanol. Changes in the fine structure of the gastric mucosa following exposure to graded concentrations of ethanol were studied in dogs. 300 ml of 12.5, 20, and 40%, vol/vol, were instilled intragastrically for 3... | [
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PMID:7954 | Some minimal effects of bile acid on canine gastric mucosa in Heidenhain pouches. | The gastric mucosa in four canine Heidenhain pouches was damaged with sodium taurocholate in a concentration which was just sufficient in each dog to produce consistent changes. Solutions were placed in the pouches and changes in the volume, concentrations, and fluxes of both hydrogen ion and sodium ion were measured b... | Some minimal effects of bile acid on canine gastric mucosa in Heidenhain pouches. The gastric mucosa in four canine Heidenhain pouches was damaged with sodium taurocholate in a concentration which was just sufficient in each dog to produce consistent changes. Solutions were placed in the pouches and changes in the volu... | [
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PMID:7955 | Stability of frozen solutions of cefazolin sodium. | The stability of frozen solutions of cefazolin sodium was investigated in nine commonly used diluents at concentrations of 1 g with 2.5 ml, 500 mg with 100 ml and 10 g with 45 ml in both glass and polyvinylchloride plastic containers. The diluents were: Water for Injection USP; 0.9% Sodium Chloride Injection USP; 5% De... | Stability of frozen solutions of cefazolin sodium. The stability of frozen solutions of cefazolin sodium was investigated in nine commonly used diluents at concentrations of 1 g with 2.5 ml, 500 mg with 100 ml and 10 g with 45 ml in both glass and polyvinylchloride plastic containers. The diluents were: Water for Injec... | [
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PMID:7957 | Takayasu's arteritis and congenital coarctation of the descending thoracic and abdominal aorta: a critical review. | A critical reappraisal of the clinical, arteriographic, and pathologic features of Takayasu's arteritis and so-called congenital aortic coarctations at atypical sites is presented. It is concluded that as an isolated cardiovascular abnormality, cases of atypical congenital coarctations of the descending thoracic and ab... | Takayasu's arteritis and congenital coarctation of the descending thoracic and abdominal aorta: a critical review. A critical reappraisal of the clinical, arteriographic, and pathologic features of Takayasu's arteritis and so-called congenital aortic coarctations at atypical sites is presented. It is concluded that as ... | [
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PMID:7958 | Multiple gastric polyps and parathyroid adenomas. Report of two cases. | Two cases of multiple gastric polyps associated with parathyroid adenomas are presented. A review of the literature revealed four patients with multiple gastric polyps and multiple endocrine adenomatosis. The possiblity of multiple gastric polyps as a variant of the MEA syndrome complex is explored. Emphasis is placed ... | Multiple gastric polyps and parathyroid adenomas. Report of two cases. Two cases of multiple gastric polyps associated with parathyroid adenomas are presented. A review of the literature revealed four patients with multiple gastric polyps and multiple endocrine adenomatosis. The possiblity of multiple gastric polyps as... | [
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PMID:7959 | Percutaneous method for arterial and venous monitoring. | A new technic for monitoring blood gases or venous and arterial pressure is described. Catheters are inserted by percutaneous puncture and guided into the femoral and iliac vessels with minimal manipulation. This rapid, simple technic has been used in more than 100 patients without a major complication. | Percutaneous method for arterial and venous monitoring. A new technic for monitoring blood gases or venous and arterial pressure is described. Catheters are inserted by percutaneous puncture and guided into the femoral and iliac vessels with minimal manipulation. This rapid, simple technic has been used in more than 10... | [
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PMID:7960 | Quantitation of local acidosis and hypoxia produced by infection. | Increased strength of healing incisions infected with E coli was demonstrated in this experiment. Efforts to measure respiratory gas tensions and pH in these incisions were unsuccessful. Therefore, these moieties were measured in normal and infected wound fluid contained in implanted wire cylinders. The wound fluid fro... | Quantitation of local acidosis and hypoxia produced by infection. Increased strength of healing incisions infected with E coli was demonstrated in this experiment. Efforts to measure respiratory gas tensions and pH in these incisions were unsuccessful. Therefore, these moieties were measured in normal and infected woun... | [
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PMID:7963 | [Controlled hypotension with sodium nitroprusside (author's transl)]. | Sodium notroprusside (Nipruss), in comparison with halothane and trimetaphan a very suitable hypotensive drug, was examined for blood pressure lowering efficency and possible side effects. For this purpose 7 patients (group 1) underwent "classical" hypotension during neurosurgical procedures. In 5 cases (group 2) nitro... | [Controlled hypotension with sodium nitroprusside (author's transl)]. Sodium notroprusside (Nipruss), in comparison with halothane and trimetaphan a very suitable hypotensive drug, was examined for blood pressure lowering efficency and possible side effects. For this purpose 7 patients (group 1) underwent "classical" h... | [
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PMID:7964 | [Ariway resistance in intensive care patients (author's transl)]. | With the modified interrupition technique airway resistance and tidal volume of bed-ridden patients can be measured simultaneously. This objective measure causes no distress to the patient. The effect of Noleptan on tidal volume and airway resistance has been studied in 28 patients (most of them have been unconscious).... | [Ariway resistance in intensive care patients (author's transl)]. With the modified interrupition technique airway resistance and tidal volume of bed-ridden patients can be measured simultaneously. This objective measure causes no distress to the patient. The effect of Noleptan on tidal volume and airway resistance has... | [
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PMID:7965 | [Studies on the stability of local anaesthetics containing adrenaline (author's transl)]. | Local toxic reactions from adrenaline following nerve block anaesthesia have been observed by many workers. Because of this potential danger we studied the changes of anaesthetic solutions containing adrenaline during a longer storage period. The measurements show a drop in the pH of the solutions caused by decompositi... | [Studies on the stability of local anaesthetics containing adrenaline (author's transl)]. Local toxic reactions from adrenaline following nerve block anaesthesia have been observed by many workers. Because of this potential danger we studied the changes of anaesthetic solutions containing adrenaline during a longer sto... | [
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PMID:7966 | [The calculation of the oxygen saturation as function of pO2, pH, temperature and base deviation (author's transl)]. | The paper describes a mathematical relationship between the partial pressure of oxygen and the oxygen saturation of the blood which approximates the standard oxygen dissociation curve. This approximation is based on a consideration of the electro-chemical equilibria of the reduced and the oxygenated blood. | [The calculation of the oxygen saturation as function of pO2, pH, temperature and base deviation (author's transl)]. The paper describes a mathematical relationship between the partial pressure of oxygen and the oxygen saturation of the blood which approximates the standard oxygen dissociation curve. This approximation... | [
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PMID:7967 | Anaesthesia with sulfentanil-analgesia in carotid and vertebral arteriography. A comparison with fentanyl. | The effects of the analgesics sulfentanil (R 30730) and fentanyl, on autonimic stability, cardiovascular stability, respiratory depression and post-operative behaviour were compared in a standardised anaesthetic technique. Twenty-nine patients undergoing neurological arteriographies, were treated with one or more doses... | Anaesthesia with sulfentanil-analgesia in carotid and vertebral arteriography. A comparison with fentanyl. The effects of the analgesics sulfentanil (R 30730) and fentanyl, on autonimic stability, cardiovascular stability, respiratory depression and post-operative behaviour were compared in a standardised anaesthetic t... | [
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PMID:7978 | [Hyperbaric oxygen therapy in cerebral circulatory insufficiency]. | From a study bearing upon 26 patients suffering from a cerebral circulatory insufficiency induced by a stenosis or a thrombosis, the writers analyse the part played by Hyperbare Oxygen in the neurologic evolution. The defining of the efficacy criteria enabled them to determine whenever this part was prevalent and obvio... | [Hyperbaric oxygen therapy in cerebral circulatory insufficiency]. From a study bearing upon 26 patients suffering from a cerebral circulatory insufficiency induced by a stenosis or a thrombosis, the writers analyse the part played by Hyperbare Oxygen in the neurologic evolution. The defining of the efficacy criteria e... | [
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PMID:7979 | [Autotransfusion in experimental hemoperitoneum. Hematologic study]. | In order to study the hematologic repercussions of pre-operative autotransfusion, ruptures were made in experimental spleens followed by retransfusion after intraperitoneal barbotage of long duration in 8 dogs. This was performed without any heparinization. The following facts could be established:--although the blood ... | [Autotransfusion in experimental hemoperitoneum. Hematologic study]. In order to study the hematologic repercussions of pre-operative autotransfusion, ruptures were made in experimental spleens followed by retransfusion after intraperitoneal barbotage of long duration in 8 dogs. This was performed without any hepariniz... | [
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PMID:7980 | [Resistance test to streptokinase. Its value in the establishing of a thrombolytic treatment using this enzyme]. | The reckoning of the rate of serous anti-streptokinase (ASK) evidenced that 8 p. 100 of the test-sample presented a distinct resistance to Streptokinase (SK), and that this percentage could be more important under certain pathological circumstances. On account of this fact and also because SK injectable preparations ma... | [Resistance test to streptokinase. Its value in the establishing of a thrombolytic treatment using this enzyme]. The reckoning of the rate of serous anti-streptokinase (ASK) evidenced that 8 p. 100 of the test-sample presented a distinct resistance to Streptokinase (SK), and that this percentage could be more important... | [
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PMID:7975 | Physostigmine reversal of sedation in parturients. | Parturients in whom meperidine HCl, propiomazine HCl, and scopolamine were used for analgesia and amnesia in labor and delivery were studied to determine the efficacy and safety of physostigmine reversal after delivery. Of a total of 120 patients, 108 received physostigmine salicylate at the completion of episiotomy cl... | Physostigmine reversal of sedation in parturients. Parturients in whom meperidine HCl, propiomazine HCl, and scopolamine were used for analgesia and amnesia in labor and delivery were studied to determine the efficacy and safety of physostigmine reversal after delivery. Of a total of 120 patients, 108 received physosti... | [
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PMID:7981 | [Presentation of equipment: the monitor of cerebral function]. | From a pair of parietal electrodes, an original apparatus--the monitor of cerebral function--gives a non-stop recording of the brain electric activity for frequencies ranging from 2 to 15 Hertz. It is at the moment less expensive than an ordinary EEG apparatus, easy to carry, to use and to read. The artefacts, interfer... | [Presentation of equipment: the monitor of cerebral function]. From a pair of parietal electrodes, an original apparatus--the monitor of cerebral function--gives a non-stop recording of the brain electric activity for frequencies ranging from 2 to 15 Hertz. It is at the moment less expensive than an ordinary EEG appara... | [
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PMID:7976 | Clinical evaluation of injectable lorazepam as a premedicant: the effect on recall. | A double-blind comparison of lorazepam and placebo, lorazepam and pentobarbital, and a comparison of lorazepam IV drip versus lorazepam IV bolus as a premedicant showed this new agent to offer promise as a sedative premedicant. However, the potency of the drug demands caution, and its use for outpatient premedication i... | Clinical evaluation of injectable lorazepam as a premedicant: the effect on recall. A double-blind comparison of lorazepam and placebo, lorazepam and pentobarbital, and a comparison of lorazepam IV drip versus lorazepam IV bolus as a premedicant showed this new agent to offer promise as a sedative premedicant. However,... | [
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PMID:7982 | [Value of moderate fentanyl dosage during anesthesis in abdominal surgery. Apropos of 100 cases]. | Fentanyl was used in 100 abdominal surgical interventions, combined with droperidol or with diazepan, always with good results as far as analgesia was concerned. Tensional variations that occurred during the induction were quite small and disappeared during the filling up. In the course of the intervention, tensional v... | [Value of moderate fentanyl dosage during anesthesis in abdominal surgery. Apropos of 100 cases]. Fentanyl was used in 100 abdominal surgical interventions, combined with droperidol or with diazepan, always with good results as far as analgesia was concerned. Tensional variations that occurred during the induction were... | [
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PMID:7977 | Fluroxene (2, 2, 2-trifluorethyl vinyl ether) toxicity: a chemical aspect. | Fluroxene is highly toxic to several animal species. This toxicity is enhanced by induction of raised levels of hepatic microsomal enzymes. Experiments in rats are described which seek to assess the rleative contribution to this toxicity of the individual component groups of the fluroxene molecule. Though results point... | Fluroxene (2, 2, 2-trifluorethyl vinyl ether) toxicity: a chemical aspect. Fluroxene is highly toxic to several animal species. This toxicity is enhanced by induction of raised levels of hepatic microsomal enzymes. Experiments in rats are described which seek to assess the rleative contribution to this toxicity of the ... | [
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PMID:7983 | [Attempt at a mathematical definition of pachycurare dosage. Application for pancuronium and AH 8165]. | Correlations among the elements indispensable to the choice of an average dose of pachycurare are established for surgical needs. Weight and duration of the surgery jointly allow to foresee with approximately 80 p. 100 accuracy the effective dose required for a surgical curarization controlled according to clinical and... | [Attempt at a mathematical definition of pachycurare dosage. Application for pancuronium and AH 8165]. Correlations among the elements indispensable to the choice of an average dose of pachycurare are established for surgical needs. Weight and duration of the surgery jointly allow to foresee with approximately 80 p. 10... | [
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PMID:7984 | [Parenteral use of a solution-emulsion following digestive surgery]. | A post-operative use of the calorico-nitrogenous mixture: Trivé 1000 was carried out in 25 patients after digestive surgery. The prescribed dose of this lipidic emulsion was 1,36 1 for an average period of four days. A study of the results led to establish the following facts:--a 55 p. cent increase in the nitrogen ret... | [Parenteral use of a solution-emulsion following digestive surgery]. A post-operative use of the calorico-nitrogenous mixture: Trivé 1000 was carried out in 25 patients after digestive surgery. The prescribed dose of this lipidic emulsion was 1,36 1 for an average period of four days. A study of the results led to esta... | [
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PMID:7985 | [Complete parenteral alimentation after major digestive surgery using lEB 51-Trivé 1000]. | The aim of this work is to study the tolerance and the effectiveness of a complete intravenous feeding with EB 51 - Trivemil in immediate post-operative period, in 40 patients undergoing major digestive surgery. The patients were divided into three groups:--first group: 25 patients were given daily an average of 2900 c... | [Complete parenteral alimentation after major digestive surgery using lEB 51-Trivé 1000]. The aim of this work is to study the tolerance and the effectiveness of a complete intravenous feeding with EB 51 - Trivemil in immediate post-operative period, in 40 patients undergoing major digestive surgery. The patients were ... | [
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PMID:7987 | [Corneal and lens deposits due to treatment by phenothiazine type neuroleptics]. | The authors have studied the corneal and lens lesions which appeared following a prolonged treatment by phenothiazines. They examined 186 patients: 147 took phenothiazines of which 35 of them presented anterior segment alterations. It seems that all phenothiazines can be held responsible for the apparition of these les... | [Corneal and lens deposits due to treatment by phenothiazine type neuroleptics]. The authors have studied the corneal and lens lesions which appeared following a prolonged treatment by phenothiazines. They examined 186 patients: 147 took phenothiazines of which 35 of them presented anterior segment alterations. It seem... | [
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PMID:7988 | [The effect of pH and partial pressure of oxygen on nitrification (author's transl)]. | A mathematical model which describes the effect of pH and dissolved oxygen on growth and activity of Nitrosomonas and Nitrobacter in mixed culture is presented. A good fit is obtained between experimental data and theoretical curves computed with parameters estimated by independent methods. Experimental data together w... | [The effect of pH and partial pressure of oxygen on nitrification (author's transl)]. A mathematical model which describes the effect of pH and dissolved oxygen on growth and activity of Nitrosomonas and Nitrobacter in mixed culture is presented. A good fit is obtained between experimental data and theoretical curves c... | [
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PMID:7989 | [Nitric oxide production in rice soils (author's transl)]. | Nitric oxide gas evolution from nitrite was studied in vitro in three rice soils by gas chromatography. Autoclaved soils showed an NO evolution when supplemented with nitrite. Yet, when temperature of incubation, soil pH, soil moisture content and nitrite concentration were varied in the three soils, and with addition ... | [Nitric oxide production in rice soils (author's transl)]. Nitric oxide gas evolution from nitrite was studied in vitro in three rice soils by gas chromatography. Autoclaved soils showed an NO evolution when supplemented with nitrite. Yet, when temperature of incubation, soil pH, soil moisture content and nitrite conce... | [
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PMID:7994 | [Effect of different pH values on the medium on the synthesis of antibiotics in the joint cultivation of Actinomyces levoris with yeasts]. | Changes in the pH level of the fermentation medium used for preliminary cultivation of C. tropicalis were studied with respect to its initial aciditv or alkalinitv. When C. tropicalis was grown on the medium used for levorin fermentation with ph 5.1--10.3, the yeast changed it in 24 hours to the level of 6.2--7.9. As d... | [Effect of different pH values on the medium on the synthesis of antibiotics in the joint cultivation of Actinomyces levoris with yeasts]. Changes in the pH level of the fermentation medium used for preliminary cultivation of C. tropicalis were studied with respect to its initial aciditv or alkalinitv. When C. tropical... | [
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PMID:7995 | [Effect of the initial pH value of the medium on the growth of Streptococcus lactis and the biosynthesis of nisin]. | The effect of the initial pH value of the medium within 4.0 to 6.6 on the growth of Str. lactis and biosynthesis of nicin was studied. It was found that at the initial pH 4.0--4.5 of the medium the growth of the culture was poor, i.e. 11--14% of the control (initiral pH 6.6). With an increase in the value of the initia... | [Effect of the initial pH value of the medium on the growth of Streptococcus lactis and the biosynthesis of nisin]. The effect of the initial pH value of the medium within 4.0 to 6.6 on the growth of Str. lactis and biosynthesis of nicin was studied. It was found that at the initial pH 4.0--4.5 of the medium the growth... | [
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PMID:7996 | [Study of E. coli penicillin amidase. The pH dependence of the equilibrium constant of the enzymatic hydrolysis of benzylpenicillin]. | The equilibrium constant for penicillin amidase-catalyzed hydrolysis of benzylpenicillin(Keg =3.00 +/- 0.24 x 10(-3) M at pH 5.0) and the ionization constants for phenylacetic acid (PAA) and the amino groups of 6-aminopenicillanic acid (6-APA) were determined (4.20 and 4.60 under conditions of the kinetic experiments r... | [Study of E. coli penicillin amidase. The pH dependence of the equilibrium constant of the enzymatic hydrolysis of benzylpenicillin]. The equilibrium constant for penicillin amidase-catalyzed hydrolysis of benzylpenicillin(Keg =3.00 +/- 0.24 x 10(-3) M at pH 5.0) and the ionization constants for phenylacetic acid (PAA)... | [
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PMID:7997 | Formation of beta-lactamase in Bacteroides fragilis: cell-bound and extracellular activity. | Nine strains of Bacteroides fragilis were cultivated in stirred fermentors and tested for their ability to produce beta-lactamase. There was a correlation between formation of beta-lactamase and high values of the minimal inhibitory concentration against beta-lactam antibiotics. B. fragilis strain B70 was used for opti... | Formation of beta-lactamase in Bacteroides fragilis: cell-bound and extracellular activity. Nine strains of Bacteroides fragilis were cultivated in stirred fermentors and tested for their ability to produce beta-lactamase. There was a correlation between formation of beta-lactamase and high values of the minimal inhibi... | [
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PMID:7998 | Enzymatic hydrolysis of cephalosporin C by an extracellular acetylhydrolase of Cephalosporium acremonium. | Extracellular hydrolases from Cephalosporium acremonium were analyzed according to their ability to deacetylate the beta-lactam antibiotic cephalosporin C. One out of at least six hydrolases exhibits appreciable cephalosporin C acetylhydrolase (CAH) activity. This enzyme was separated from other hydrolases and purified... | Enzymatic hydrolysis of cephalosporin C by an extracellular acetylhydrolase of Cephalosporium acremonium. Extracellular hydrolases from Cephalosporium acremonium were analyzed according to their ability to deacetylate the beta-lactam antibiotic cephalosporin C. One out of at least six hydrolases exhibits appreciable ce... | [
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PMID:7999 | Autolysis of high-GC isolates of Pseudomonas putrefaciens. | High-GC isolates of P. putrefaciens undergo extensive autolysis after growth, resulting in a marked decrease in turbidity and the release of high-molecular-weight DNA which imparts a high viscosity to culture broths. The native DNA released is resistant to attack by the exocellular DNase activity of the culture broths.... | Autolysis of high-GC isolates of Pseudomonas putrefaciens. High-GC isolates of P. putrefaciens undergo extensive autolysis after growth, resulting in a marked decrease in turbidity and the release of high-molecular-weight DNA which imparts a high viscosity to culture broths. The native DNA released is resistant to atta... | [
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PMID:8000 | Microbial metabolism of ethylene. | The ethylene-oxidizing strain E20 was grown on different carbon sources to obtain information on the metabolism of ethylene from simultaneous adaptation studies and from measurements of specific activities of enzymes in cell-free extracts. From the simultaneous adaptation studies it was concluded that ethylene oxide is... | Microbial metabolism of ethylene. The ethylene-oxidizing strain E20 was grown on different carbon sources to obtain information on the metabolism of ethylene from simultaneous adaptation studies and from measurements of specific activities of enzymes in cell-free extracts. From the simultaneous adaptation studies it wa... | [
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PMID:8001 | Characterization of the neoagarotetra-ase and neoagarobiase of Cytophaga flevensis. | The degradation of neoagarotetraose and neoagarobiose by Cytophaga flevensis was investigated. The organism possesses an enzyme that hydrolyzes the tetramer by cleavage of its central beta-galactosidic linkage. The product of this reaction, neoagarobiose, is further hydrolyzed enzymatically to D-galactose and 3,6-anhyd... | Characterization of the neoagarotetra-ase and neoagarobiase of Cytophaga flevensis. The degradation of neoagarotetraose and neoagarobiose by Cytophaga flevensis was investigated. The organism possesses an enzyme that hydrolyzes the tetramer by cleavage of its central beta-galactosidic linkage. The product of this react... | [
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PMID:8002 | Purification and some properties of an extracellular maltase from Bacillus subtilis. | Bacillus subtilis P-11, capable of producing extracellular maltase, was isolated from soil. Maximum enzyme production was obtained on a medium containing 2.0% methyl-alpha-D-glucose, 0.5% phytone, and 0.2% yeast extract. After the removal of cells, extracellular maltase was precipitated by ammonium sulfate (85% saturat... | Purification and some properties of an extracellular maltase from Bacillus subtilis. Bacillus subtilis P-11, capable of producing extracellular maltase, was isolated from soil. Maximum enzyme production was obtained on a medium containing 2.0% methyl-alpha-D-glucose, 0.5% phytone, and 0.2% yeast extract. After the remo... | [
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PMID:8003 | Influence of growth temperature on glucose metabolism of a psychotrophic strain of Bacillus cereus. | The influence of temperature on glucose metabolism of a psychotrophic strain of Bacillus cereus was investigated. The pH of the growth medium and spore-forming frequencies of B. cereus varied when grown at 32, 20, or 7 C. Radiorespirometric analyses revealed that vegetative cells of B. cereus metabolized glucose by sim... | Influence of growth temperature on glucose metabolism of a psychotrophic strain of Bacillus cereus. The influence of temperature on glucose metabolism of a psychotrophic strain of Bacillus cereus was investigated. The pH of the growth medium and spore-forming frequencies of B. cereus varied when grown at 32, 20, or 7 C... | [
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PMID:8004 | Inhibition of Clostridium perfringens by heated combinations of nitrite, sulfur, and ferrous or ferric ions. | Heating mixtures of sodium nitrite, cysteine, and either ferrous sulfate or ferric chloride at 121 C for 20 min at pH 6.5 or 6.3 produced a potent inhibitor of Clostridium perfringens vegetative cells and spores when added to previously heat-sterilized fluid thioglycolate medium. When the mixtures containing FeSO4 at p... | Inhibition of Clostridium perfringens by heated combinations of nitrite, sulfur, and ferrous or ferric ions. Heating mixtures of sodium nitrite, cysteine, and either ferrous sulfate or ferric chloride at 121 C for 20 min at pH 6.5 or 6.3 produced a potent inhibitor of Clostridium perfringens vegetative cells and spores... | [
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PMID:8005 | Pathways of microbial metabolism of parathion. | A mixed bacterial culture, consisting of a minimum of nine isolates, was adapted to growth on technical parathion (PAR) as a sole carbon and energy source. The primary oxidative pathway for PAR metabolism involved an initial hydrolysis to yield diethylthiophosphoric acid and p-nitrophenol. A secondary oxidative pathway... | Pathways of microbial metabolism of parathion. A mixed bacterial culture, consisting of a minimum of nine isolates, was adapted to growth on technical parathion (PAR) as a sole carbon and energy source. The primary oxidative pathway for PAR metabolism involved an initial hydrolysis to yield diethylthiophosphoric acid a... | [
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PMID:8006 | Microbiological oxidation of synthetic chalcocite and covellite by Thiobacillus ferrooxidans. | The microbiological oxidation of synthetic chalcocite and covellite has been investigated using an adapted strain of Thiobacillus ferrooxidans. Biodegradation of chalcocite was found to be 90 to 100% and that of covellite 45 to 60%. Optimum conditions for the oxidation of chalcocite were: pH, 1.7 to 2.3; temperature, 3... | Microbiological oxidation of synthetic chalcocite and covellite by Thiobacillus ferrooxidans. The microbiological oxidation of synthetic chalcocite and covellite has been investigated using an adapted strain of Thiobacillus ferrooxidans. Biodegradation of chalcocite was found to be 90 to 100% and that of covellite 45 t... | [
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PMID:8016 | Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia. | Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemi... | Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia. Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplanta... | [
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PMID:8017 | Human skin proteases. Separation and characterization of two acid proteases resembling cathepsin B1 and cathepsin D and of an inhibitor of cathepsin B1. | Two acid proteases, one hydrolysing hemoglobin and the other hydrolysing benzoyl arginine naphthyamide (BANA), were separated and partially purified from human skin buffer extract. The acid protease hydrolysing hemoglobin was purified about 190 fold by Sephadex G-100 gel filtration and DEAE-cellulose chromatography. It... | Human skin proteases. Separation and characterization of two acid proteases resembling cathepsin B1 and cathepsin D and of an inhibitor of cathepsin B1. Two acid proteases, one hydrolysing hemoglobin and the other hydrolysing benzoyl arginine naphthyamide (BANA), were separated and partially purified from human skin bu... | [
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PMID:8021 | Hypotensive action of propranolol and a new beta-blocking agent, D-32 in conscious normotensive and renal hypertensive dogs. | The hypotensive actions of dl-propranolol and a new beta-blocking agent, dl-tert-butylamino-3-(2', 3'-dimethylphenoxy)-2-propanol hydrochloride (D-32) were studied in conscious normotensive and renal hypertensive dogs, using a cross-over design. The effects were compared with that of placebo (lactose 200 mg/head, p.o.)... | Hypotensive action of propranolol and a new beta-blocking agent, D-32 in conscious normotensive and renal hypertensive dogs. The hypotensive actions of dl-propranolol and a new beta-blocking agent, dl-tert-butylamino-3-(2', 3'-dimethylphenoxy)-2-propanol hydrochloride (D-32) were studied in conscious normotensive and r... | [
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PMID:8022 | Inhibition by suprofen and other non-narcotic analgesic drugs of the effects of prostaglandin precursor on isolated tissues and platelets. | Contractions caused by Slow Reacting Substance C(SRS-C) and by Arachidonic Acid hydroperoxide (AAP) in the guinea-pig ileum and by AAP in the rat fundus were studied in the presence of suprofen and of 3 reference compounds. The dose-related inhibitions were not due to antagonism of prostaglandins. Other agonists of gas... | Inhibition by suprofen and other non-narcotic analgesic drugs of the effects of prostaglandin precursor on isolated tissues and platelets. Contractions caused by Slow Reacting Substance C(SRS-C) and by Arachidonic Acid hydroperoxide (AAP) in the guinea-pig ileum and by AAP in the rat fundus were studied in the presence... | [
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PMID:8018 | Some natural products from two soft coals. Their removal, metal-binding and enzyme inhibitory activity. | The chemical constituents of coal have not been fully characterized in relation to the incidence of coal workers' pneumoconiosis (CWP). In this study two soft coals obtained from mines in which workers had high and low incidences of CWP were leached with aqueous base and acid to remove their acidic and basic components... | Some natural products from two soft coals. Their removal, metal-binding and enzyme inhibitory activity. The chemical constituents of coal have not been fully characterized in relation to the incidence of coal workers' pneumoconiosis (CWP). In this study two soft coals obtained from mines in which workers had high and l... | [
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PMID:8023 | Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics. | Using a food-reinforced two-lever operant procedure, rats (n=6) were trained to discriminate fentanyl (1.25 mg/kg, p.o., t-60') from solvent (1 ml/100 g B.W., p.o., t-60'). The administration of another narcotic analgesic (pethidine) produced a dose-related generalization with the standard fentanyl treatment; six non-n... | Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics. Using a food-reinforced two-lever operant procedure, rats (n=6) were trained to discriminate fentanyl (1.25 mg/kg, p.o., t-60') from solvent (1 ml/100 g B.W., p.o., t-60'). The administration of another narcotic analgesic (p... | [
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PMID:8024 | Comparative doses and costs of antipsychotic medication. | It is clinically useful to have a table listing the equivalent doses of the various neuroleptics to a standard, such as chlorpromazine. This article derives such data by reviewing double-blind controlled studies that used a flexible dosage schedule of neuroleptics in treating schizophrenic patients. Each neuroleptic is... | Comparative doses and costs of antipsychotic medication. It is clinically useful to have a table listing the equivalent doses of the various neuroleptics to a standard, such as chlorpromazine. This article derives such data by reviewing double-blind controlled studies that used a flexible dosage schedule of neuroleptic... | [
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PMID:8025 | Pharmacokinetics of red blood cell phenothiazine and clinical effects. Acute dystonic reactions. | Pharmacokinetics of the phenothiazine, butaperazine, were studied in relationship to acute dystonic reactions. Dystonias appeared on falling drug concentrations, more than one half-life after plasma and red blood cell (RBC) peak butaperazine concentrations. Red blood cell butaperazine kinetics differentiated better tha... | Pharmacokinetics of red blood cell phenothiazine and clinical effects. Acute dystonic reactions. Pharmacokinetics of the phenothiazine, butaperazine, were studied in relationship to acute dystonic reactions. Dystonias appeared on falling drug concentrations, more than one half-life after plasma and red blood cell (RBC)... | [
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PMID:8026 | Takayasu arteritis. An arteriographic-pathological correlation. | We report an aortographic-pathological correlation in a patient with Takayasu arteritis. The inflammatory activity in Takayasu arteritis gradually subsides and accordingly, the histological appearance goes through a cycle of changes, ranging from acute florid inflammation to an old scarred vessel. At gross pathological... | Takayasu arteritis. An arteriographic-pathological correlation. We report an aortographic-pathological correlation in a patient with Takayasu arteritis. The inflammatory activity in Takayasu arteritis gradually subsides and accordingly, the histological appearance goes through a cycle of changes, ranging from acute flo... | [
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PMID:8027 | Paragangliomatosis associated with multiple endocrine adenomas. | A 19-year-old woman had multiple functioning extra-adrenal paragangliomas, a pituitary adenoma associated with acromegaly, parathyroid hyperplasia, and pigmentary abnormalities. This case differs from previously described instances of multiple endocrine adenomatosis (MEA) and has features that bridge the classic MEA ty... | Paragangliomatosis associated with multiple endocrine adenomas. A 19-year-old woman had multiple functioning extra-adrenal paragangliomas, a pituitary adenoma associated with acromegaly, parathyroid hyperplasia, and pigmentary abnormalities. This case differs from previously described instances of multiple endocrine ad... | [
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PMID:8028 | A case of pneumococcal typhlitis. | A 29-year-old man had abdominal pain for 24 hours. This and the results of an abdominal examination were typical of acute appendicitis. He had suffered sinusitis for two weeks. At operation, the appendix was normal; there was an abscess in the cecal wall, the exudate of which grew pneumococci. Incidental appendectomy w... | A case of pneumococcal typhlitis. A 29-year-old man had abdominal pain for 24 hours. This and the results of an abdominal examination were typical of acute appendicitis. He had suffered sinusitis for two weeks. At operation, the appendix was normal; there was an abscess in the cecal wall, the exudate of which grew pneu... | [
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PMID:8032 | Analgesic nephropathy. | Analgesic nephropathy occurs most commonly in Australia, where it is the second most frequent cause of renal failure. Whilst the reasons for widespread abuse of analgesics are poorly understood, the consequences of abuse are now well recognised. Increasing emphasis is being placed on the analgesic syndrome and on the a... | Analgesic nephropathy. Analgesic nephropathy occurs most commonly in Australia, where it is the second most frequent cause of renal failure. Whilst the reasons for widespread abuse of analgesics are poorly understood, the consequences of abuse are now well recognised. Increasing emphasis is being placed on the analgesi... | [
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PMID:8034 | A study of the surface pH of the urinary bladder during distension in rabbits. | Bladder wall surface pH has been continuously monitored with a glass pH electrode using a simple, atraumatic technique. Experiments have been performed in the rabbit showing that there is a progressive fall in bladder wall pH as the intravesical pressure is increased. The changes in bladder wall pH serve as a sensitive... | A study of the surface pH of the urinary bladder during distension in rabbits. Bladder wall surface pH has been continuously monitored with a glass pH electrode using a simple, atraumatic technique. Experiments have been performed in the rabbit showing that there is a progressive fall in bladder wall pH as the intraves... | [
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PMID:8035 | The purification and properties of the glutamine synthetase from the cytosol of Soya-bean root nodules. | The major portion of glutamine synthetase activity in root nodules of soya-bean plants is associated with the cytosol rather than with Rhizobium japonicum bacteroids. Glutamine synthetase accounts for about 2% of the total soluble protein in nodule cytosol. Glutamine synthetase from nodule cytosol has been purified by ... | The purification and properties of the glutamine synthetase from the cytosol of Soya-bean root nodules. The major portion of glutamine synthetase activity in root nodules of soya-bean plants is associated with the cytosol rather than with Rhizobium japonicum bacteroids. Glutamine synthetase accounts for about 2% of the... | [
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PMID:8036 | Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates. | 1. The activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenase were measured in muscles from a large number of animals, in order to provide some indication of the importance of the citric acid cycle in these muscles. According to the differences in enzyme activities, the muscles can be div... | Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates. 1. The activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenase were measured in muscles from a large number of animals, in order to provide some indication... | [
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PMID:8037 | Autophagy-related changes of arylsulphatases A and B in rat liver lysosomes. | The total arylsulphatase activity and the relative activities of lysosomal arylsulphatases A and B were measured in the liver of control rats and rats subjected to treatments that provoke hepatic autophagocytosis. The total liver arylsulphatase activities were increased in starved and starved glucagon-treated rats, but... | Autophagy-related changes of arylsulphatases A and B in rat liver lysosomes. The total arylsulphatase activity and the relative activities of lysosomal arylsulphatases A and B were measured in the liver of control rats and rats subjected to treatments that provoke hepatic autophagocytosis. The total liver arylsulphatas... | [
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PMID:8038 | Hydrogen-ion titration studies on erythrocyte membranes. | 1. H+ titration was used to detect the presence of ionizable groups on human erythrocyte plasma membranes. Between pH2.9 and 11.3, two significant peaks of H+ association/dissociation occur in the differential from of the titration curve, one at pH3. 1. And the other at pH10.3. 2. After disruption of membrane structure... | Hydrogen-ion titration studies on erythrocyte membranes. 1. H+ titration was used to detect the presence of ionizable groups on human erythrocyte plasma membranes. Between pH2.9 and 11.3, two significant peaks of H+ association/dissociation occur in the differential from of the titration curve, one at pH3. 1. And the o... | [
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PMID:8039 | The route of secretion of procollagen. The influence of alphaalpha'-bipyridyl, colchicine and antimycin A on the secretory process in embryonic-chick tendon and cartilage cells. | I. Embryonic-chick tendon cells were pulse-labelled for 4 min with [14C]proline and the 14C-labelled polypeptides were chased with unlabelled proline for up to 30 min. Isolation of subcellular fractions during the chase period and their subsequent analysis for bacterial collagenase-susceptible 14C-labelled peptides dem... | The route of secretion of procollagen. The influence of alphaalpha'-bipyridyl, colchicine and antimycin A on the secretory process in embryonic-chick tendon and cartilage cells. I. Embryonic-chick tendon cells were pulse-labelled for 4 min with [14C]proline and the 14C-labelled polypeptides were chased with unlabelled ... | [
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PMID:8040 | The effects of proteolytic digestion by trypsin on the structure and catalytic properties of reduced nicotinamide-adenine dinucleotide dehydrogenase from bovine heart mitochondria. | 1. At 21 degrees C incubation of NADH-ubiquinone-1 reductase (Complex 1) with trypsin caused selective inhibition of nicotinamide nucleotide transhydrogenase activity. The reduction of K3Fe(CN)6 by NADH or NADPH was unaffected, but a slow decrease in the rate of reduction of ubiquinone-1 by NADH was observed. 2. The pH... | The effects of proteolytic digestion by trypsin on the structure and catalytic properties of reduced nicotinamide-adenine dinucleotide dehydrogenase from bovine heart mitochondria. 1. At 21 degrees C incubation of NADH-ubiquinone-1 reductase (Complex 1) with trypsin caused selective inhibition of nicotinamide nucleotid... | [
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PMID:8041 | The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate). Experiments with glucose and nicotinamide. | 1. Chronic administration of glucose or nicotinamide in drinking water inhibits the activity of rat liver tryptophan pyrrolase, and subsequent withdrawal causes an enhancement. The enzyme activity is also inhibited by administration in drinking water of sucrose, but not fructose, which is capable of preventing the gluc... | The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate). Experiments with glucose and nicotinamide. 1. Chronic administration of glucose or nicotinamide in drinking water inhibits the activity of rat liver tryptophan pyrrolase, and subsequent withdrawal causes ... | [
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PMID:8056 | Basic ethers of cyclohexylphenols with beta-blocking activity: synthesis and pharmacological study of exaprolol. | The paper describes the preparation and study of the pharmacological properties of a series of derivatives with the general formula. (see article) where R is a cyclohexyl or cyclohexenyl radical and R1 is a hydrogen, methyl or cyclohexyl. The compounds with a single cycloaliphatic radical ortho to the basic chain, and ... | Basic ethers of cyclohexylphenols with beta-blocking activity: synthesis and pharmacological study of exaprolol. The paper describes the preparation and study of the pharmacological properties of a series of derivatives with the general formula. (see article) where R is a cyclohexyl or cyclohexenyl radical and R1 is a ... | [
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PMID:8057 | General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity. | 1-(2-Methoxy-2-phenyl)-ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)-propyl-iperazine-dihydrochloride (zipeprol, Respilene) is a substance of non-phenanthrenic chemical structure. In the cat, it antagonised cough induced by stimulation of the superior laryngeal nerve or by direct mechanical excitation of the sensitive tracheo... | General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity. 1-(2-Methoxy-2-phenyl)-ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)-propyl-iperazine-dihydrochloride (zipeprol, Respilene) is a substance of non-phenanthrenic chemical structure. In ... | [
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PMID:8058 | [Bronchospasmolytic activity of aqueous aerosols in anesthetized dogs (author's transl)]. | A modification of the method of Konzett and Rössler is described. This modification allows the administration of atomised drug solutions to anaesthetised dogs. Information is thus obtained on the bronchodilatory activity of a drug and the onset and duration of effect. Two anticholinergics (atropinsulfate and ipratropiu... | [Bronchospasmolytic activity of aqueous aerosols in anesthetized dogs (author's transl)]. A modification of the method of Konzett and Rössler is described. This modification allows the administration of atomised drug solutions to anaesthetised dogs. Information is thus obtained on the bronchodilatory activity of a drug... | [
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PMID:8059 | Actions of narcotics on brain dopamine metabolism and their relevance for "psychomotor" effects. | A review is given about the effects of narcotic analgesics, particularly of morphine, on the dopamine metabolism in the corpus striatum and about the relations of these effects to motility and "psychomotor" phenomena. In rats, acute doses of morphine decrease the dopaminergic neurotransmission in brain, without blockin... | Actions of narcotics on brain dopamine metabolism and their relevance for "psychomotor" effects. A review is given about the effects of narcotic analgesics, particularly of morphine, on the dopamine metabolism in the corpus striatum and about the relations of these effects to motility and "psychomotor" phenomena. In ra... | [
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PMID:8060 | Metabolic deacetylation: in vitro and in vivo studies in man, rat, dog and rhesus monkey with isomeric tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate. | The pharmacological activities of a racemic mixture of tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate, (+/-) Ro 03-4661 and the corresponding resolved isomers (+) Ro 03-4661 and (--) Ro 03-4661 have been studied in rat and rhesus monkey. The racemate and the (--) isomer showed narcotic analgesic activi... | Metabolic deacetylation: in vitro and in vivo studies in man, rat, dog and rhesus monkey with isomeric tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate. The pharmacological activities of a racemic mixture of tetrahydroisoquinolyl derivatives of 3,4-dimethylbenzyl acetate, (+/-) Ro 03-4661 and the corresp... | [
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PMID:8061 | Purification and characterization of lipoprotein lipase from human heart. | Human heart lipoprotein lipase was purified by affinity chromatography on heparin-Sepharose 4B. When crude extracts of heart acetone powder were applied to columsn, about 40% of total lipase activity was bound to the gel and then eluted with 1.5 M NaCl. At this stage the eluted enzyme was purified 1900-fold. Disc gel e... | Purification and characterization of lipoprotein lipase from human heart. Human heart lipoprotein lipase was purified by affinity chromatography on heparin-Sepharose 4B. When crude extracts of heart acetone powder were applied to columsn, about 40% of total lipase activity was bound to the gel and then eluted with 1.5 ... | [
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PMID:8062 | Neurogenic hypercholesterolemia: influence of autonomic drugs. | Eleven substances capable of either augmenting or depleting the alpha- and - beta-adrenergic capacities of the autonomic nervous system were administered to rats exhibiting hypothalamic hypercholesterolemia and to normal controls. Only the beta-adrenergic blocking agents propranolol and possibly 6-OH dopamine were obse... | Neurogenic hypercholesterolemia: influence of autonomic drugs. Eleven substances capable of either augmenting or depleting the alpha- and - beta-adrenergic capacities of the autonomic nervous system were administered to rats exhibiting hypothalamic hypercholesterolemia and to normal controls. Only the beta-adrenergic b... | [
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PMID:8063 | Effects of some benzodiazepine derivatives on Triton WR-1339-Induced hyperlipidaemia in rats. | Oral administration of the benzodiazepines (diazepam, lorazepam, chlordiazepoxide, bipotassium chlorazepate) in Triton WR-1339-induced (200 mg/kg, blood collection 18 h later) hyperlipidaemia in rats elicited marked decrease of serum total lipids, total cholesterol and triglyceride levels, and alterations in free fatty... | Effects of some benzodiazepine derivatives on Triton WR-1339-Induced hyperlipidaemia in rats. Oral administration of the benzodiazepines (diazepam, lorazepam, chlordiazepoxide, bipotassium chlorazepate) in Triton WR-1339-induced (200 mg/kg, blood collection 18 h later) hyperlipidaemia in rats elicited marked decrease o... | [
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PMID:8068 | Clinical studies of induction agents XLIII: Flunitrazepam. | Flunitrazepam (Ro 5-4200) has been studied as an induction agent in 220 volunteers or patients. It was assumed to be 10 times as potent as diazepam. The maximum soporific effect did not occur until 90-120 s after injection. There was great individual variation in response to flunitrazepam and some patients did not lose... | Clinical studies of induction agents XLIII: Flunitrazepam. Flunitrazepam (Ro 5-4200) has been studied as an induction agent in 220 volunteers or patients. It was assumed to be 10 times as potent as diazepam. The maximum soporific effect did not occur until 90-120 s after injection. There was great individual variation ... | [
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PMID:8070 | Salmefamol and Salbutamol in exercise-induced asthma in children. | A double-blind controlled study is reported of salmefamol 200 mug and salbutamol 200 mug administered by aerosol before exercise tests in asthmatic children. Both drugs prevented exercise-induced asthma. There was no significant difference between them. | Salmefamol and Salbutamol in exercise-induced asthma in children. A double-blind controlled study is reported of salmefamol 200 mug and salbutamol 200 mug administered by aerosol before exercise tests in asthmatic children. Both drugs prevented exercise-induced asthma. There was no significant difference between them. | [
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PMID:8071 | The role of divalent cations in epidermolysis. | In experiments designed to elucidate the role of divalent cations in maintaining the integrity of the epidermis, newborn mouse skin was incubated in ethylenediamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA). In EDTA, epidermolysis occurred and was confirmed by rubbing the specimen to demonstrat... | The role of divalent cations in epidermolysis. In experiments designed to elucidate the role of divalent cations in maintaining the integrity of the epidermis, newborn mouse skin was incubated in ethylenediamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA). In EDTA, epidermolysis occurred and was ... | [
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PMID:8073 | Planned pregnancy in a renal transplant recipient. | A scheme is described for the investigation and management of a renal transplant recipient before conception, over conception and during the subsequent pregnancy, delivery and puerperium. The patient showed the physiological changes in homeostasis of normal pregnancy. Methods of monitoring maternal, fetal and renal wel... | Planned pregnancy in a renal transplant recipient. A scheme is described for the investigation and management of a renal transplant recipient before conception, over conception and during the subsequent pregnancy, delivery and puerperium. The patient showed the physiological changes in homeostasis of normal pregnancy. ... | [
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PMID:8074 | Effect of oral 17-beta-oestradiol on the liver in women with intrahepatic cholestasis (hepatosis) during previous pregnancy. | The effects of 17-beta-oestradiol in 14 women who had had intrahepatic cholestasis of pregnancy (hepatosis) were studied. This natural oestrogen was given orally in a daily dose of 5 mg for two 20-day periods with a 7-day interval between courses. The bromsulphthalein (BSP) retention rose during the treatment, but only... | Effect of oral 17-beta-oestradiol on the liver in women with intrahepatic cholestasis (hepatosis) during previous pregnancy. The effects of 17-beta-oestradiol in 14 women who had had intrahepatic cholestasis of pregnancy (hepatosis) were studied. This natural oestrogen was given orally in a daily dose of 5 mg for two 2... | [
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PMID:8076 | Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase. | In addition to 8alpha-(N3-histidyl)riboflavin, 8alpha-(N1-histidyl)riboflavin is also formed during the reaction of Nalpha-blocked histidine with 8alpha-bromotetraacetylriboflavin in a yield of 20-25% of the total histidylflavin fraction. The properties of 8alpha-(N1-histidyl)riboflavin are inditical with those of the ... | Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase. In addition to 8alpha-(N3-histidyl)riboflavin, 8alpha-(N1-histidyl)riboflavin is also formed during the reaction of Nalpha-blocked histidine with 8alpha-bromotetr... | [
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PMID:8077 | Energetics of primary processes in visula escitation: photocalorimetry of rhodopsin in rod outer segment membranes. | A sensitive technique for the direct calorimetric determination of the energetics of photochemical reactions under low levels of illumination, and its application to the study of primary processes in visula excitation, are described. Enthlpies are reported for various steps in the bleaching of rhodopsin in intact rod o... | Energetics of primary processes in visula escitation: photocalorimetry of rhodopsin in rod outer segment membranes. A sensitive technique for the direct calorimetric determination of the energetics of photochemical reactions under low levels of illumination, and its application to the study of primary processes in visu... | [
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PMID:8078 | Characterization of 20S component in tubulin from mammalian brain. | Tubulin from porcine brain, purified by at least two cycles of assembly and disassembly, was characerized at different pH values by sedimentation velocity analysis and turbidimetric measurements. At pH 6.4 the depolymerized material was composed of two major species sedimenting with so20,w values of 6 and 36 and a mino... | Characterization of 20S component in tubulin from mammalian brain. Tubulin from porcine brain, purified by at least two cycles of assembly and disassembly, was characerized at different pH values by sedimentation velocity analysis and turbidimetric measurements. At pH 6.4 the depolymerized material was composed of two ... | [
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PMID:8079 | Histone interactions in solution and susceptibility to denaturation. | Histone interactions in solution may depend upon treatments used for purification. Optical rotatory dispersion and sedimentation-velocity measurements have been made in a reference solvent, before and after exposure to various treatments, to investigate histone susceptibility to irreversible denaturation. Some acid con... | Histone interactions in solution and susceptibility to denaturation. Histone interactions in solution may depend upon treatments used for purification. Optical rotatory dispersion and sedimentation-velocity measurements have been made in a reference solvent, before and after exposure to various treatments, to investiga... | [
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... |
PMID:8080 | Structural analysis of O2'-methyl-5-carbamoylmethyluridine, a newly discovered constituent of yeast transfer RNA. | A compound tentatively identified as O2-methyl-5-carboxymethyluridine (cm5Um) was recently isolated in this laboratory from bulk yeast transfer RNA (Gray, M. W. (1975), Can, J. Biochem. 53, 735-746). Alkaline hydrolysis of yeast tRNA releases this nucleoside as part of an alkali-stable dinucleotide, cm5Um-Ap, from whic... | Structural analysis of O2'-methyl-5-carbamoylmethyluridine, a newly discovered constituent of yeast transfer RNA. A compound tentatively identified as O2-methyl-5-carboxymethyluridine (cm5Um) was recently isolated in this laboratory from bulk yeast transfer RNA (Gray, M. W. (1975), Can, J. Biochem. 53, 735-746). Alkali... | [
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PMID:8081 | Mechanisms of electron transfer from sulfite to horseradish peroxidase-hydroperoxide compounds. | Using a rapid-scan spectrophotometer equipped with a stopped-flow apparatus, reactions of sulfite with compounds I and II of two horseradish peroxidase isoenzymes A and C were investigated. The direct two-electron reduction of peroxidase compound I by sulfite occurred at acidic pH but the mechanism gradually changed to... | Mechanisms of electron transfer from sulfite to horseradish peroxidase-hydroperoxide compounds. Using a rapid-scan spectrophotometer equipped with a stopped-flow apparatus, reactions of sulfite with compounds I and II of two horseradish peroxidase isoenzymes A and C were investigated. The direct two-electron reduction ... | [
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... |
PMID:8082 | Vinylglycine and proparglyglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase. | Proparglyglycine (2-amino-4-pentynoate) and vinylglycine (2-amino-3-butenoate) have been examined as substrates and possible inactivators of two flavo enzymes, D-amino acid oxidase from pig kidney and L-amino acid oxidase from Crotalus adamanteus venom. Vinylglycine is rapidly oxidized by both enzymes but only L-amino ... | Vinylglycine and proparglyglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase. Proparglyglycine (2-amino-4-pentynoate) and vinylglycine (2-amino-3-butenoate) have been examined as substrates and possible inactivators of two flavo enzymes, D-amino acid oxidase from pig kidney and ... | [
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0.055511124432086945,
-0.04738213121891022,
0.06989449262619019,
0.0... |
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