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PMID:8201 | Critical opening pressure and reactivity of tail vessels in conscious hypertensive rats. | The possible role of increased vascular reactivity in the mechanism of experimental hypertension was studied by measurements of the critical opening pressure (COP) of tail vessels in conscious rats. In hypertension induced by administration of desoxycorticosterone acetate (DOCA) and replacement of the drinking water by... | Critical opening pressure and reactivity of tail vessels in conscious hypertensive rats. The possible role of increased vascular reactivity in the mechanism of experimental hypertension was studied by measurements of the critical opening pressure (COP) of tail vessels in conscious rats. In hypertension induced by admin... | [
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PMID:8202 | Effects of isoproterenol on cyclic-AMP metabolism in rat ventral prostate. | Beta-Adrenergic stimulation of the ventral prostate cyclic-AMP system was investigated by examining the influence of isoproterenol on endogenous cyclic-AMP levels as well as on the activities of adenylate cyclase CEC 4.6.1.1) and cyclic-AMP-dependent and independent protein kinases (EC 2.7.1.37). Administration of isop... | Effects of isoproterenol on cyclic-AMP metabolism in rat ventral prostate. Beta-Adrenergic stimulation of the ventral prostate cyclic-AMP system was investigated by examining the influence of isoproterenol on endogenous cyclic-AMP levels as well as on the activities of adenylate cyclase CEC 4.6.1.1) and cyclic-AMP-depe... | [
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PMID:8203 | Epinephrine-induced hepatic potassium movements before and after adrenergic blockade. | The epinephrine-induced loss and subsequent uptake of K+ by the liver was studied by measuring hepatic arterio-venous K+ differences and splanchnic blood flows in anesthetized dogs with chronically implanted portal vein catheters and celiac and superior mesenteric artery flow probes. When epinephrine was administered i... | Epinephrine-induced hepatic potassium movements before and after adrenergic blockade. The epinephrine-induced loss and subsequent uptake of K+ by the liver was studied by measuring hepatic arterio-venous K+ differences and splanchnic blood flows in anesthetized dogs with chronically implanted portal vein catheters and ... | [
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PMID:8204 | Blockade of histamine-induced contractions of guinea pig ielum by beta-haloalkylamines. | In the longitudinal muscle strip of guinea pig ileum phenoxybenzamine (POB) produces a maximum parallel shift of 0.7 log units in the dose-response curve to histamine. In the presence of sodium thiosulfate in the wash fluid the parallel shift whith retention of maximum response increases to about 2 log units, and a sim... | Blockade of histamine-induced contractions of guinea pig ielum by beta-haloalkylamines. In the longitudinal muscle strip of guinea pig ileum phenoxybenzamine (POB) produces a maximum parallel shift of 0.7 log units in the dose-response curve to histamine. In the presence of sodium thiosulfate in the wash fluid the para... | [
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PMID:8205 | Postsplenectomy sepsis due to influenzal viremia and pneumococcemia. | A 31-year-old man, who had undergone splenectomy 18 months previously because of hereditary spherocytosis, suddenly became ill, with fever, vomiting, epigastric pain and shock, and died 10 hours after the onset of his symptoms. Autopsy showed influenzal viremia, pneumococcemia and bilateral adrenal hemorrhage. The rapi... | Postsplenectomy sepsis due to influenzal viremia and pneumococcemia. A 31-year-old man, who had undergone splenectomy 18 months previously because of hereditary spherocytosis, suddenly became ill, with fever, vomiting, epigastric pain and shock, and died 10 hours after the onset of his symptoms. Autopsy showed influenz... | [
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PMID:8206 | Malignant germ cell tumor in situ in a cryptorchid testis. | A case of a malignant undifferentiated germ cell tumor in situ of an undescended testis diagnosed by needle biopsy is described. Four similar cases have been so far recorded in the literature, all of them in the infertile men with normally descended descended testes. Two of them developed embryonal carcinoma of testis ... | Malignant germ cell tumor in situ in a cryptorchid testis. A case of a malignant undifferentiated germ cell tumor in situ of an undescended testis diagnosed by needle biopsy is described. Four similar cases have been so far recorded in the literature, all of them in the infertile men with normally descended descended t... | [
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PMID:8207 | Understanding neurotransmitters and related drugs. | Chemical neurotransmitter substances are released at the axon terminals of the central, autonomic, and peripheral nervous systems of the human body. The most well-known of the neurotransmitters are acetylcholine, norepinephrine, dopamine, and serotonin. It is these substances that facilitate the conduction of nerve imp... | Understanding neurotransmitters and related drugs. Chemical neurotransmitter substances are released at the axon terminals of the central, autonomic, and peripheral nervous systems of the human body. The most well-known of the neurotransmitters are acetylcholine, norepinephrine, dopamine, and serotonin. It is these sub... | [
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PMID:8208 | Muscular work and the release of prostaglandin-like substances. | Experimental evidence for the release of prostaglandin-like substances, mainly of the E type, into the venous outflow from working skeletal muscles in the dog is described. Muscular exercise of the hind-leg produced by sciatic nerve stimulation evoked the release of prostaglandin-like substances detected in femoral ven... | Muscular work and the release of prostaglandin-like substances. Experimental evidence for the release of prostaglandin-like substances, mainly of the E type, into the venous outflow from working skeletal muscles in the dog is described. Muscular exercise of the hind-leg produced by sciatic nerve stimulation evoked the ... | [
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PMID:8210 | Fine structure of complex ocelli of a cubomedusan, Tamoya bursaria Haeckel. | The retina of the distal and proximal lens-bearing complex ocelli are composed of pigmented sensory cells and long pigmented cells. A ciliary sheath from each sensory cell, together with the processes of long pigmented cells, extends through the vitreous layer as far as the capsule that envelops the lens. Each ciliary ... | Fine structure of complex ocelli of a cubomedusan, Tamoya bursaria Haeckel. The retina of the distal and proximal lens-bearing complex ocelli are composed of pigmented sensory cells and long pigmented cells. A ciliary sheath from each sensory cell, together with the processes of long pigmented cells, extends through th... | [
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PMID:8211 | The mechanism of action of ppGpp on rRNA synthesis in vitro. | We have studied the mechanism of the specific inhibition of ribosomal RNA synthesis by ppGpp in a purified system using as templates E. coli DNA and DNA from lambdad5ilv, which carries a rRNA cistron from E. coli. Ribosomal RNA synthesis, as well as its inhibition by ppGpp, are critically salt-dependent. Of a number of... | The mechanism of action of ppGpp on rRNA synthesis in vitro. We have studied the mechanism of the specific inhibition of ribosomal RNA synthesis by ppGpp in a purified system using as templates E. coli DNA and DNA from lambdad5ilv, which carries a rRNA cistron from E. coli. Ribosomal RNA synthesis, as well as its inhib... | [
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PMID:8212 | Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells. | Effects of glutamine on glutamine synthetase (GS) activity of hepatoma tissue culture (HTC) cells were studied with the aid of a specific goat anti-rat GS serum. Immunodiffusion and immunoelectrophoretic tests show that rat liver GS and HTC cell GS are immunologically similar but not identical. Immunotitrations of HTC ... | Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells. Effects of glutamine on glutamine synthetase (GS) activity of hepatoma tissue culture (HTC) cells were studied with the aid of a specific goat anti-rat GS serum. Immunodiffusion and immunoelectrophoretic tests sh... | [
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PMID:8213 | Membrane receptors for murine leukemia viruses: characterization using the purified viral envelope glycoprotein, gp71. | The 71,000 dalton glycoprotein (gp71) purified from Rauscher murine leukemia virus (R-MuLV) by affinity chromatography specifically binds to murine but not other mammalian cells in culture. Binding is prevented by specific antiserum raides to gp71 (anti-gp71). The binding assay as described in this report can detect re... | Membrane receptors for murine leukemia viruses: characterization using the purified viral envelope glycoprotein, gp71. The 71,000 dalton glycoprotein (gp71) purified from Rauscher murine leukemia virus (R-MuLV) by affinity chromatography specifically binds to murine but not other mammalian cells in culture. Binding is ... | [
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PMID:8214 | Naturally occurring cross-links in yeast chromosomal DNA. | Chromosome-size yeast DNA molecules with a number average molecular weight (Mn) of 3-4 X 10(8) were isolated from sucrose gradients after sedimentation of lysed yeast spheroplasts. Resedimentation showed that the molecules were isolated without introducing appreciable single-strand or double-strand breaks. The presence... | Naturally occurring cross-links in yeast chromosomal DNA. Chromosome-size yeast DNA molecules with a number average molecular weight (Mn) of 3-4 X 10(8) were isolated from sucrose gradients after sedimentation of lysed yeast spheroplasts. Resedimentation showed that the molecules were isolated without introducing appre... | [
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PMID:8216 | The effect of allyl compounds on hepatic microsomal mixed function oxidation and porphyrogenesis. | The activities of 5-aminolaevulinate (5-ALA) synthetase and of various microsomat drug-metabolising enzymes have been determined in the livers of rats pretreated with different drugs and chemicals containing the allyl group. Safrole, isosafrole and secobarbital gave rise to slight increases in 5-ALA synthetase, whereas... | The effect of allyl compounds on hepatic microsomal mixed function oxidation and porphyrogenesis. The activities of 5-aminolaevulinate (5-ALA) synthetase and of various microsomat drug-metabolising enzymes have been determined in the livers of rats pretreated with different drugs and chemicals containing the allyl grou... | [
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PMID:8217 | The action of a binary nonionic detergent on a kidney membrane fraction. | The disruption of a kidney cortex microsomal membrane preparation by a binary, nonionic detergent, was followed by using as markers, the changes in total protein content, and (Na+, K+)-ATPase in a supernatant fraction. Both markers responded similarly to changes in pH, microsome concentration and detergent concentratio... | The action of a binary nonionic detergent on a kidney membrane fraction. The disruption of a kidney cortex microsomal membrane preparation by a binary, nonionic detergent, was followed by using as markers, the changes in total protein content, and (Na+, K+)-ATPase in a supernatant fraction. Both markers responded simil... | [
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PMID:8218 | Resistance of alkylated DNA to degradation by deoxyribonuclease II at neutral and acid pH. | Methylation of a calf thymus DNA substrate by dimethyl sulphate (DMS) leads to an inhibition of deoxyribonuclease II activity which is gradually lost with time. The extent of this initial inhibition is linearly related to the amount of methylated products in DNA and quantitatively similar effects were found when the en... | Resistance of alkylated DNA to degradation by deoxyribonuclease II at neutral and acid pH. Methylation of a calf thymus DNA substrate by dimethyl sulphate (DMS) leads to an inhibition of deoxyribonuclease II activity which is gradually lost with time. The extent of this initial inhibition is linearly related to the amo... | [
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PMID:8219 | Enzymatic properties of native and N-ethylmaleimide-modified cardiac myosin from normal and thyrotoxic rabbits. | Cardiac myosin from thyrotoxic animals (myosin-T) exhibits elevated Ca2+ -ATPase activity which is resistant to further stimulation by sulfhydryl modification. In the present study, we have compared the enzymatic properties of myosin-T with those of myosin from euthyroid rabbits (myosin-N) and the derivatives of myosin... | Enzymatic properties of native and N-ethylmaleimide-modified cardiac myosin from normal and thyrotoxic rabbits. Cardiac myosin from thyrotoxic animals (myosin-T) exhibits elevated Ca2+ -ATPase activity which is resistant to further stimulation by sulfhydryl modification. In the present study, we have compared the enzym... | [
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PMID:8220 | The association between serum triglycerides and gamma glutamyl transpeptidase activity in diabetes mellitus. | A study conducted on 228 diabetic patients has shown a significant positive association between serum gamma-glutamyl transpeptidase (GGT) and triglyceride levels. Both fall with treatment, the most marked reduction occurring in patients on insulin. We suggest that the association between serum GGT and triglyceride leve... | The association between serum triglycerides and gamma glutamyl transpeptidase activity in diabetes mellitus. A study conducted on 228 diabetic patients has shown a significant positive association between serum gamma-glutamyl transpeptidase (GGT) and triglyceride levels. Both fall with treatment, the most marked reduct... | [
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PMID:8221 | Reverse-phase chromatography of polar biological substances: separation of catechol compounds by high-performance liquid chromatography. | Catecholamines and their metabolites have been separated isocratically by reverse-phase chromatography with aqueous (no organic solvent admixed) eluents. Unlike ion-exchange or ion-pair chromatography, mixtures of both acidic and basic substances can be separated in a single chromatographic run, because the retention i... | Reverse-phase chromatography of polar biological substances: separation of catechol compounds by high-performance liquid chromatography. Catecholamines and their metabolites have been separated isocratically by reverse-phase chromatography with aqueous (no organic solvent admixed) eluents. Unlike ion-exchange or ion-pa... | [
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PMID:8222 | Diagnosis of infectious hepatitis by multicomponent analysis with use of field ionization mass spectrometry. | Field ionization mass spectrometry has been applied to multicomponent analysis of metabolites in human urine for the diagnosis of metabolic disorders, exemplified here by infectious hepatitis. The molecular weight profiles of carboxylic acids and of "neutral" metabolites in the urine of patients with infectious hepatit... | Diagnosis of infectious hepatitis by multicomponent analysis with use of field ionization mass spectrometry. Field ionization mass spectrometry has been applied to multicomponent analysis of metabolites in human urine for the diagnosis of metabolic disorders, exemplified here by infectious hepatitis. The molecular weig... | [
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PMID:8223 | Reversed-phase liquid-chromatographic analysis of hemodialysate from uremic patients. | With reversed-phase high-performance liquid chromatography we effected rapid and efficient separation of metabolites present in hemodialysate fluid from uremic patients on the artificial kidney. With an aqueous sodium acetate/methanol gradient as mobile phase, more than 50 ultraviolet-absorbing constituents were resolv... | Reversed-phase liquid-chromatographic analysis of hemodialysate from uremic patients. With reversed-phase high-performance liquid chromatography we effected rapid and efficient separation of metabolites present in hemodialysate fluid from uremic patients on the artificial kidney. With an aqueous sodium acetate/methanol... | [
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PMID:8226 | Human leukocyte acid hydrolases: characterization of eleven lysosomal enzymes and study of reaction conditions for their automated analysis. | The optimal reaction conditions and kinetic properties of eleven leukocyte acid hydrolases determined with the use of fluorigenic derivatives of 4-methyl-umbelliferone are described. The enzymes studied were acid phosphatase, aryl sulfatase, alpha- and beta-glucosidase, alpha- and beta-galactosidase, alpha-mannosidase,... | Human leukocyte acid hydrolases: characterization of eleven lysosomal enzymes and study of reaction conditions for their automated analysis. The optimal reaction conditions and kinetic properties of eleven leukocyte acid hydrolases determined with the use of fluorigenic derivatives of 4-methyl-umbelliferone are describ... | [
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PMID:8227 | Oestrogen induced hypertriglyceridaemia: role of the adrenal cortex. | The role of the adrenal cortex in the pathogenesis of hypertriglyceridaemia associated with the intake of oral contraceptive agents containing oestrogen has been investigated in rats. Bilateral adrenalectomy reduced the activity of hepatic enzymes regulating lipogenesis (acetyl CoA carboxylase, fatty acid synthetase) a... | Oestrogen induced hypertriglyceridaemia: role of the adrenal cortex. The role of the adrenal cortex in the pathogenesis of hypertriglyceridaemia associated with the intake of oral contraceptive agents containing oestrogen has been investigated in rats. Bilateral adrenalectomy reduced the activity of hepatic enzymes reg... | [
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PMID:8228 | Increased survival times of New Zealand hybrid mice immunosuppressed by graft-versus-host reactions. | New Zealand mice develop autoimmune disease usually accompanied by glomerulonephritis. A graft-versus-host reaction was induced in New Zealand Black X New Zealand White F1 hybrid mice by administration of New Zealand White spleen cells. The mice so treated had diminished antibody responses to both an exogenous antigen ... | Increased survival times of New Zealand hybrid mice immunosuppressed by graft-versus-host reactions. New Zealand mice develop autoimmune disease usually accompanied by glomerulonephritis. A graft-versus-host reaction was induced in New Zealand Black X New Zealand White F1 hybrid mice by administration of New Zealand Wh... | [
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PMID:8230 | Organic acidemias. | Inherited organic acidemias are a group of metabolic disorders currently being described and investigated as gas-liquid chromatography is applied to unexplained diseases of infancy and childhood. Common clinical presentations include attacks of ketoacidosis, unexplained metabolic acidosis, failure of normal development... | Organic acidemias. Inherited organic acidemias are a group of metabolic disorders currently being described and investigated as gas-liquid chromatography is applied to unexplained diseases of infancy and childhood. Common clinical presentations include attacks of ketoacidosis, unexplained metabolic acidosis, failure of... | [
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PMID:8231 | Antihypertensive action of propranolol in man: lack of evidence for a neural depressive effect. | The hypothesis that a neural depressive action is related to the antihypertensive effects of beta blockers has been evaluated in 14 essential hypertensive male patients through the circulatory response to noxious stimuli. The pressor reaction to mental arithmetic was primarily mediated by cardiac stimulation (beta rece... | Antihypertensive action of propranolol in man: lack of evidence for a neural depressive effect. The hypothesis that a neural depressive action is related to the antihypertensive effects of beta blockers has been evaluated in 14 essential hypertensive male patients through the circulatory response to noxious stimuli. Th... | [
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PMID:8229 | Calcificaiton of growth plate cartilage with special reference to studies on micropuncture fluids. | No final comprehensive hypothesis of the chain of events involved in inhibition of calcification can be constructed at the present time. The flow diagram in Figure 1 is presented only as a working hypothesis currently used by the authors. Insofar as the Cfl is representative of native factors at calcifying sites, none ... | Calcificaiton of growth plate cartilage with special reference to studies on micropuncture fluids. No final comprehensive hypothesis of the chain of events involved in inhibition of calcification can be constructed at the present time. The flow diagram in Figure 1 is presented only as a working hypothesis currently use... | [
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PMID:8232 | Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam. | Eight healthy male subjects received single 2-mg oral doses of lorazepam containing 24 muCi/mg of 2-14C-lorazepam. Multiple venous blood samples were drawn during the first 96 hr after the dose, and all urine and stool were collected for 120 hr after dosing. Concentrations of lorazepam and its metabolites in body fluid... | Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam. Eight healthy male subjects received single 2-mg oral doses of lorazepam containing 24 muCi/mg of 2-14C-lorazepam. Multiple venous blood samples were drawn during the first 96 hr after the dose, and all urine and stool were col... | [
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PMID:8233 | Effect of age on oxygen-binding in normal human subjects. | 1. Oxygen-binding, plasma and intra-erythrocytic pH, and haemoglobin, 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years. 2. P50 (oxygen tension at 50% oxygen saturation) expressed at plasma pH 7-40 and PCO2 5-33 kPa showed a positiv... | Effect of age on oxygen-binding in normal human subjects. 1. Oxygen-binding, plasma and intra-erythrocytic pH, and haemoglobin, 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years. 2. P50 (oxygen tension at 50% oxygen saturation) expr... | [
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PMID:8234 | Intracellular acid-base heterogeneity in nucleated avian erythrocytes. | 1. Intracellular hydrogen ion activity, [H+]i, was extimated in human erythrocytes and in nucleated avian erythrocytes from measurements of the distribution of ammonia and 5,5'-dimethyloxazolidine-2,4'-dione (DMO) between intracellular and extracellular fluid. 2. In human erythrocytes there was no difference between va... | Intracellular acid-base heterogeneity in nucleated avian erythrocytes. 1. Intracellular hydrogen ion activity, [H+]i, was extimated in human erythrocytes and in nucleated avian erythrocytes from measurements of the distribution of ammonia and 5,5'-dimethyloxazolidine-2,4'-dione (DMO) between intracellular and extracell... | [
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PMID:8236 | Telephone management of poisonings using syrup of ipecac. | Seven hundred and seventy-six cases were studied during a six-month period to see if induction of emesis could be successfully managed at home by telephone. Emesis was successful in 98.8% of cases. In 6.7% of all cases, symptoms were found at 4-hour follow-up that were referrable to the ingestion, but all were consider... | Telephone management of poisonings using syrup of ipecac. Seven hundred and seventy-six cases were studied during a six-month period to see if induction of emesis could be successfully managed at home by telephone. Emesis was successful in 98.8% of cases. In 6.7% of all cases, symptoms were found at 4-hour follow-up th... | [
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PMID:8278 | Cyclic AMP and cyclic GMP in epidermal physiology and pathophysiology. | The second messengers cyclic AMP and cyclic GMP in several organs appear to coordinate those molecular events which are responsible for specialized organ function. As a result of balanced cell proliferation and specialization, epidermis functions by terminal specialization which provides a barrier between man and envir... | Cyclic AMP and cyclic GMP in epidermal physiology and pathophysiology. The second messengers cyclic AMP and cyclic GMP in several organs appear to coordinate those molecular events which are responsible for specialized organ function. As a result of balanced cell proliferation and specialization, epidermis functions by... | [
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PMID:8283 | Pleural fluid pH in parapneumonic effusions. | The pH and carbon dioxide tension were measured in 24 consecutive parapneumonic effusions, along with the leukocyte count, leukocytic differential count, and levels of glucose and protein. Three categories of parapneumonic effusions were characterized: (1) empyemas; (2) benign (nonloculated) effusions; and (3) loculate... | Pleural fluid pH in parapneumonic effusions. The pH and carbon dioxide tension were measured in 24 consecutive parapneumonic effusions, along with the leukocyte count, leukocytic differential count, and levels of glucose and protein. Three categories of parapneumonic effusions were characterized: (1) empyemas; (2) beni... | [
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PMID:8284 | Lipid binding of a halothane metabolite. Relationship to lipid peroxidation in vitro. | Incubation of rat liver microsomes with 14C-halothane in a nitrogen atmosphere results in a high correlation between the formation of conjugated dienes and the binding of a halothane metabolite to phospholipids. Both the binding and the formation of the conjugated dienes required NADPH, were inhibited by carbon monoxid... | Lipid binding of a halothane metabolite. Relationship to lipid peroxidation in vitro. Incubation of rat liver microsomes with 14C-halothane in a nitrogen atmosphere results in a high correlation between the formation of conjugated dienes and the binding of a halothane metabolite to phospholipids. Both the binding and t... | [
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PMID:8285 | Studies on the mechanism of toxicity and of development of tolerance to the pulmonary toxin, alpha-naphthylthiourea (ANTU). | The in vivo administration of the radiolabeled lung toxin alpha-naphthylthiourea (ANTU) to rats leads to the covalent binding of radioactivity to the macromolecules of the lung and liver. In contrast, very little radioactivity is bound in these organs when an equal amount of the 14C-labeled oxygen analog of ANTU, 14C-a... | Studies on the mechanism of toxicity and of development of tolerance to the pulmonary toxin, alpha-naphthylthiourea (ANTU). The in vivo administration of the radiolabeled lung toxin alpha-naphthylthiourea (ANTU) to rats leads to the covalent binding of radioactivity to the macromolecules of the lung and liver. In contr... | [
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PMID:8286 | Stereospecific binding of timolol, a beta-adrenergic blocking agent. | The beta-adrenergic blocking agent, timolol, appears to be bound to stereospecific as well as nonspecific sites in the particulate fraction (8500g pellet) of the heart, lungs, and brain, whereas the d-isomer of timolol was bound to nonspecific sites only. Timolol disappeared from the particulate fraction at a slower ra... | Stereospecific binding of timolol, a beta-adrenergic blocking agent. The beta-adrenergic blocking agent, timolol, appears to be bound to stereospecific as well as nonspecific sites in the particulate fraction (8500g pellet) of the heart, lungs, and brain, whereas the d-isomer of timolol was bound to nonspecific sites o... | [
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PMID:8287 | Inversion of optical configuration of alpha-methylfluorene-2-acetic acid (cicloprofen) in rats and monkeys. | A simple and sensitive radiometric method to determine the individual enantiomers of cicloprofen has been developed. 14C-Cicloprofen was converted to its L-leucine diastereoisomers, which were separated by thin-layer chromatography and quantified by measuring the radioactivity in the area corresponding to each individu... | Inversion of optical configuration of alpha-methylfluorene-2-acetic acid (cicloprofen) in rats and monkeys. A simple and sensitive radiometric method to determine the individual enantiomers of cicloprofen has been developed. 14C-Cicloprofen was converted to its L-leucine diastereoisomers, which were separated by thin-l... | [
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PMID:8288 | Buffer catalysis of the racemization reaction of some 5-phenylhydantoins and its relation to the in vivo metabolism of ethotoin. | Evidence is presented to show that an optical isomer of 5-phenylhydantoin is subject to racemization (interconversion) in different buffer systems. With phosphate buffers in the pH range of 6.0-7.5, it appears that the buffer-catalyzed racemization reaction is due solely to catalysis by divalent phosphate (general base... | Buffer catalysis of the racemization reaction of some 5-phenylhydantoins and its relation to the in vivo metabolism of ethotoin. Evidence is presented to show that an optical isomer of 5-phenylhydantoin is subject to racemization (interconversion) in different buffer systems. With phosphate buffers in the pH range of 6... | [
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PMID:8289 | 5,5-Bis(3-hydroxyphenyl)hydantoin, a minor metabolite of diphenylhydantoin (dilantin) in the rat and human. | 5,5-Bis(4-hydroxyphenyl) hydantoin has been identified as a minor metabolite of diphenylhydantoin (DPH) in the rat and human. This metabolite was synthesized in the laboratory from 4,4'-dihydroxybenzophenone. Gas chromatographic and mass spectrometric comparison of the permethylated synthetic compound with the permethy... | 5,5-Bis(3-hydroxyphenyl)hydantoin, a minor metabolite of diphenylhydantoin (dilantin) in the rat and human. 5,5-Bis(4-hydroxyphenyl) hydantoin has been identified as a minor metabolite of diphenylhydantoin (DPH) in the rat and human. This metabolite was synthesized in the laboratory from 4,4'-dihydroxybenzophenone. Gas... | [
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PMID:8290 | Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies. | Metabolism of dihalomethanes by rat liver cytosol fractions yielded formaldehyde and inorganic halide as products. Loss of metabolic activity resulting from dialysis of the cytosol was restored with glutathione. Cysteine could not substitute for GSH. No other cofactor was found to be required for activity. The optimum ... | Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies. Metabolism of dihalomethanes by rat liver cytosol fractions yielded formaldehyde and inorganic halide as products. Loss of metabolic activity resulting from dialysis of the cytosol was restored with glutathione. Cysteine could not s... | [
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PMID:8291 | Metabolism of 2,4,5,2',5'-pentachlorobiphenyl in the rat. Qualitative and quantitative aspects. | The metabolism of 2,4,5,2',5'-pentachloro [14C] biphenyl (5-CB) was studied in the male rat. Following iv administration of 5-CB (0.6 mg/kg), 84% of the total dose was excreted within 7 days and 89% of the radioactivity excreted was in the form of 5-CB metabolites. Mass spectral and proton nuclear magnetic resonance an... | Metabolism of 2,4,5,2',5'-pentachlorobiphenyl in the rat. Qualitative and quantitative aspects. The metabolism of 2,4,5,2',5'-pentachloro [14C] biphenyl (5-CB) was studied in the male rat. Following iv administration of 5-CB (0.6 mg/kg), 84% of the total dose was excreted within 7 days and 89% of the radioactivity excr... | [
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PMID:8292 | 3-(Hydroxymethyl)-8-methoxychromone and unconjugated metabolites in rat plasma. Identification of the biologically active species. | After administering 14C-labeled 3-(hydroxymethyl)-8-methoxychromone to rats by gavage, plasma was found to contain unchanged compound and three unconjugated metabolites. These metabolites were identified as 3-carboxy-8-methoxychromone, 8-methoxychromone, and 2-hydroxy-3-methoxyactophenone. The plasma levels of all four... | 3-(Hydroxymethyl)-8-methoxychromone and unconjugated metabolites in rat plasma. Identification of the biologically active species. After administering 14C-labeled 3-(hydroxymethyl)-8-methoxychromone to rats by gavage, plasma was found to contain unchanged compound and three unconjugated metabolites. These metabolites w... | [
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PMID:8293 | Metabolism of tripelennamine in man. | Four polar metabolites were isolated from the urine of human subjects orally treated with tripelennamine, and their structures elucidated by various chemical and physical methods. One of the metabolites, which is a minor one, was identified as an N-oxide of tripelennamine, and the other three as glucuronide conjugates.... | Metabolism of tripelennamine in man. Four polar metabolites were isolated from the urine of human subjects orally treated with tripelennamine, and their structures elucidated by various chemical and physical methods. One of the metabolites, which is a minor one, was identified as an N-oxide of tripelennamine, and the o... | [
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PMID:8294 | Disposition and metabolism of 3-(3-chlorophenoxy)-N-methylpyrrolidine [14C]-carboxamide in the rat, dog, and man. | Studies with a 14C-labeled sample have shown that the title compound A is readily absorbed and very rapidly excreted by the rat, dog, and man. The metabolites result from aromatic ring hydroxylation, oxidation, and dealkylation of the urea methyl group, and oxidative ring opening of the pyrrolidine ring. Rat metabolite... | Disposition and metabolism of 3-(3-chlorophenoxy)-N-methylpyrrolidine [14C]-carboxamide in the rat, dog, and man. Studies with a 14C-labeled sample have shown that the title compound A is readily absorbed and very rapidly excreted by the rat, dog, and man. The metabolites result from aromatic ring hydroxylation, oxidat... | [
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PMID:8295 | Physiological disposition and metabolic fate of a new antiarrhythmic agent, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl) benzylamine in the rat, dog, monkey, baboon, and man. | The physiological disposition of a new orally active antiarrhythmic drug, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl)benzylamine (MK-251) was investigated in the rat, dog, rhesus monkey, baboon, and man. MK-251 was extensively absorbed after oral administration in all species. Fecal excretio... | Physiological disposition and metabolic fate of a new antiarrhythmic agent, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl) benzylamine in the rat, dog, monkey, baboon, and man. The physiological disposition of a new orally active antiarrhythmic drug, alpha, alpha-dimethyl-4-(alpha, alpha, beta,... | [
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PMID:8298 | [Treatment of hypertrophic obstructive cardiomyopathy with verapamil, a calcium antagonist (author's transl)]. | Cardiac catheterisation with pressure measurements, left-ventricular cine-angiography and selective coronary angiography confirmed the diagnosis of hypertrophic obstructive cardiomyopathy in 20 patients. After a mean observation period of 20 months during which most of them were treated with beta-blockers, verapamil, 4... | [Treatment of hypertrophic obstructive cardiomyopathy with verapamil, a calcium antagonist (author's transl)]. Cardiac catheterisation with pressure measurements, left-ventricular cine-angiography and selective coronary angiography confirmed the diagnosis of hypertrophic obstructive cardiomyopathy in 20 patients. After... | [
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PMID:8296 | Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat. | A thin-layer chromatographic procedure is described for the quantitative determination of phenacetin and acetaminophen in rat plasma. The method was used to determine the effect of 3-methylcholanthrene (3-MC) on the disposition and bioavailability of phenacetin following its oral and iv administration to rats. Pretreat... | Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat. A thin-layer chromatographic procedure is described for the quantitative determination of phenacetin and acetaminophen in rat plasma. The method was used to determine the effect of 3-methylcholanthrene (3-MC) on the disposition... | [
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PMID:8297 | Effect of methadone dose on the biliary excretion of methadone metabolites in the rat. | The effect of three different doses of 14C-methadone (0.08, 1.0 and 2.5 mg/kg) on the biliary excretion of methadone metabolites was studied in the rat. After administration of the 0.08- and 1.0-mg/kg doses of 14C-methadone there was no difference in the percentage of administered 14C excreted into bile with time. Howe... | Effect of methadone dose on the biliary excretion of methadone metabolites in the rat. The effect of three different doses of 14C-methadone (0.08, 1.0 and 2.5 mg/kg) on the biliary excretion of methadone metabolites was studied in the rat. After administration of the 0.08- and 1.0-mg/kg doses of 14C-methadone there was... | [
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PMID:8301 | [Studies on optimising rubella virus haemagglutination-inhibitor tests]. | Immuno-electrophoretic and serological studies were undertaken to characterise the non-specific serum inhibitor of rubella haemagglutination. The majority of such inhibitor effects come from the beta(1)-lipoproteins. In addition, small inhibitory effects which were due to alpha(1)-lipoproteins were noted in some sera. ... | [Studies on optimising rubella virus haemagglutination-inhibitor tests]. Immuno-electrophoretic and serological studies were undertaken to characterise the non-specific serum inhibitor of rubella haemagglutination. The majority of such inhibitor effects come from the beta(1)-lipoproteins. In addition, small inhibitory ... | [
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PMID:8306 | Inactivation of porcine calcitonin by rat kidney microsome. | Biological activity of porcine calcitonin was most actively inactivated by the rat kidney homogenate than by other tissue homogenates. Among the various subcellular fractions of the rat kidney homogenate examined, microsome fraction was most active in the in vitro inactivation of porcine calcitonin. Inactivation of por... | Inactivation of porcine calcitonin by rat kidney microsome. Biological activity of porcine calcitonin was most actively inactivated by the rat kidney homogenate than by other tissue homogenates. Among the various subcellular fractions of the rat kidney homogenate examined, microsome fraction was most active in the in v... | [
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PMID:8307 | Estimation of testosterone binding capacity in the serum with hydrophobie resin. | A method for the estimation of the serum testosterone binding capacity (TeBC) using hydrophobic resin, Amberlite XAD-2, was developed. The serum was incubated with a saturating amount of testosterone-1,2(-3)H at 15 degrees C, unbound testosterone was adsorbed to the resin and the 3H-radoiactivity remaining in the super... | Estimation of testosterone binding capacity in the serum with hydrophobie resin. A method for the estimation of the serum testosterone binding capacity (TeBC) using hydrophobic resin, Amberlite XAD-2, was developed. The serum was incubated with a saturating amount of testosterone-1,2(-3)H at 15 degrees C, unbound testo... | [
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PMID:8308 | Dynamic asymmetries in liver tyrosine aminotransferase induction. | Changes in liver tyrosine aminotransferase activity were measured in mice and rats following a whole body X-irradiation in order to ascertain the dose-effect relationship. The response was either (1) linear in case of low pulses (25 rad/min); (2) parabolic, indicating the onset of a saturation process in case of medium... | Dynamic asymmetries in liver tyrosine aminotransferase induction. Changes in liver tyrosine aminotransferase activity were measured in mice and rats following a whole body X-irradiation in order to ascertain the dose-effect relationship. The response was either (1) linear in case of low pulses (25 rad/min); (2) parabol... | [
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PMID:8309 | Amino acid metabolizing enzymes in rat submaxillary gland, normal or neoplastic, and in pancreas. | The activities of 12 enzymes, many related to ornithine metabolism, were measured in rat submaxillary gland, submaxillary gland tumors and pancreas. In submaxillary gland, the activities of arginase, ornithine aminotransferase, pyrroline-5-carboxylate reductase and glutamine synthetase were high, but no ornithine trans... | Amino acid metabolizing enzymes in rat submaxillary gland, normal or neoplastic, and in pancreas. The activities of 12 enzymes, many related to ornithine metabolism, were measured in rat submaxillary gland, submaxillary gland tumors and pancreas. In submaxillary gland, the activities of arginase, ornithine aminotransfe... | [
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PMID:8310 | Relationships of femoral venous [K+], PO2, osmolality, and [orthophosphate) with heart rate, ventilation, and leg blood flow during bicycle exercise in athletes and non-athletes. | The relationship of femoral venous [K+], [H+], osmolality (OSM), PO2, and [inorganic phosphate] ([Pi]) with heart rate (HR), ventilation (VE), and calculated leg blood flow (Q) were investigated during bicycle exercise in endurance trained (TR) and untrained (UT) test subjects. At a given VO2 the increases of [K+], OSM... | Relationships of femoral venous [K+], PO2, osmolality, and [orthophosphate) with heart rate, ventilation, and leg blood flow during bicycle exercise in athletes and non-athletes. The relationship of femoral venous [K+], [H+], osmolality (OSM), PO2, and [inorganic phosphate] ([Pi]) with heart rate (HR), ventilation (VE)... | [
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PMID:8311 | On the transport of tripeptide antibiotics in bacteria. | The two tripeptide antibiotics L-2-amino-4-methylphosphinobutyryl-alanyl-alanyl-alanine (L-phosphinothricyl-alanyl-alanine) and L-(N5-phosphono)methionine-S-sulfoximinyl-alanyl-alanine, both inhibitors of the glutamine synthetase, are transported into the cell of Escherichia coli K 12 via the oligopeptide transport sys... | On the transport of tripeptide antibiotics in bacteria. The two tripeptide antibiotics L-2-amino-4-methylphosphinobutyryl-alanyl-alanyl-alanine (L-phosphinothricyl-alanyl-alanine) and L-(N5-phosphono)methionine-S-sulfoximinyl-alanyl-alanine, both inhibitors of the glutamine synthetase, are transported into the cell of ... | [
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PMID:8312 | Yeast hexokinase: substrate-induced association--dissociation reactions in the binding of glucose to hexokinase P-II. | A method is described for the purification of native hexokinases P-I and P-II from yeast using preparative isoelectric focussing to separate the isozymes. The binding of glucose to hexokinase P-II, and the effect of this on the monomer--dimer association--dissociation reaction have been investigated quantitatively by a... | Yeast hexokinase: substrate-induced association--dissociation reactions in the binding of glucose to hexokinase P-II. A method is described for the purification of native hexokinases P-I and P-II from yeast using preparative isoelectric focussing to separate the isozymes. The binding of glucose to hexokinase P-II, and ... | [
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PMID:8313 | Affinity chromatography and binding studies on immobilized 5'-monophosphate and adenosine 2',5'-bisphosphate of nicotinamide nucleotide transhydrogenase from Pseudomonas aeruginosa. | 1. Nicotinamide nucleotide transhydrogenase from Pseudomonas aeruginosa was purified to apparent homogeneity with an improved method employing affinity chromatography on N6-(6aminohexyl)-adenosine 2', 5'-bisphosphate-Sepharose 4B. 2. Polyacrylamide gel electrophoresis of the purified transhydrogenase carried out in the... | Affinity chromatography and binding studies on immobilized 5'-monophosphate and adenosine 2',5'-bisphosphate of nicotinamide nucleotide transhydrogenase from Pseudomonas aeruginosa. 1. Nicotinamide nucleotide transhydrogenase from Pseudomonas aeruginosa was purified to apparent homogeneity with an improved method emplo... | [
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PMID:8314 | Somatic antigens of shigella. Structural investigation on the O-specific polysaccharide chain of Shigella dysenteriae type 1 lipopolysaccharide. | The O-specific polysaccharide obtained from the lipopolysaccharide of Shigella dysenteriae type 1 (Shigella shiga) by mild acid hydrolysis followed by fractionation on Sephadex G-50 was found to be identical to that desribed by Morgan's group and was composed of L-rhamnose, D-galactose and N-acetyl-D-glycosamine in a r... | Somatic antigens of shigella. Structural investigation on the O-specific polysaccharide chain of Shigella dysenteriae type 1 lipopolysaccharide. The O-specific polysaccharide obtained from the lipopolysaccharide of Shigella dysenteriae type 1 (Shigella shiga) by mild acid hydrolysis followed by fractionation on Sephade... | [
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PMID:8315 | Purification and properties of 3-hexulosephosphate synthase from Methylomonas M 15. | 3-Hexulosephosphate synthase, the first enzyme of the ribulose monophosphate cycle, was purified 15-fold from methanol-grown Methylomonas M 15. The purification procedure involved chromatography on DEAE-cellulose, Sephadex G-75, and DEAE-Sephadex A-50. The purified enzyme was more than 95% pure as judged by analytical ... | Purification and properties of 3-hexulosephosphate synthase from Methylomonas M 15. 3-Hexulosephosphate synthase, the first enzyme of the ribulose monophosphate cycle, was purified 15-fold from methanol-grown Methylomonas M 15. The purification procedure involved chromatography on DEAE-cellulose, Sephadex G-75, and DEA... | [
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PMID:8316 | Interest of isoproterenol in the treatment of hemorrhagic shock in dogs. | Four groups of experiments were focused on two problems: first, the replacement of the substracted amount of blood, and second, the correction of the peripheral reactions to substantial blood loss, namely vasoconstriction and acidosis. We stuck to a simple plan in our experiments: lost blood was entirely collected and ... | Interest of isoproterenol in the treatment of hemorrhagic shock in dogs. Four groups of experiments were focused on two problems: first, the replacement of the substracted amount of blood, and second, the correction of the peripheral reactions to substantial blood loss, namely vasoconstriction and acidosis. We stuck to... | [
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PMID:8317 | The noradrenergic cyclic AMP generating system in the limbic forebrain: pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics. | The cyclic AMP generating system in slices of the rat limbic forebrain was investigated. In consists of: (u) A noradrenergic system which responds to norepinephrine (NE) and isoproterenol. Though the rise of the nucleotide elicited by isoproterenol is more rapid than that caused by NE, the maximal effect is less than h... | The noradrenergic cyclic AMP generating system in the limbic forebrain: pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics. The cyclic AMP generating system in slices of the rat limbic forebrain was investigated. In consists of: (u) A n... | [
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PMID:8318 | Effect of propranolol of vascular responses to sympathetic nerve stimulation and plasma renin activity in mongrel dogs. | I.v administration of propranolol (0.2 mg/kg and 1.0 mg/kg) to pentobarbital-anesthetized dogs produced blockade of cardiac beta-receptors and a significant decrease in heart rate. However, only the higher dose of propranolol demonstrated a significant hypotensive effect. Furthermore, this hypotensive action of propran... | Effect of propranolol of vascular responses to sympathetic nerve stimulation and plasma renin activity in mongrel dogs. I.v administration of propranolol (0.2 mg/kg and 1.0 mg/kg) to pentobarbital-anesthetized dogs produced blockade of cardiac beta-receptors and a significant decrease in heart rate. However, only the h... | [
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PMID:8319 | Hypotensive responses following oral adminstration of beta-adrenoceptor blocking drugs to the conscious cat. | On oral administration, the non-selective beta-adrenoceptor blocking drugs (+/-)-bufuralol, (-)-bufuralol, propanolol, oxprenolol, pindolol and alprenolol produced hypotensive responses in the conscious cat; (+)-bufuralol was without effect. The selective beta-adrenoceptor blocking drugs practolol and atenolol had no e... | Hypotensive responses following oral adminstration of beta-adrenoceptor blocking drugs to the conscious cat. On oral administration, the non-selective beta-adrenoceptor blocking drugs (+/-)-bufuralol, (-)-bufuralol, propanolol, oxprenolol, pindolol and alprenolol produced hypotensive responses in the conscious cat; (+)... | [
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PMID:8320 | A kinetic analysis of a catechol-specific binding site in the microsomal fraction from the rabbit aorta. | (-)-3/-Norepinephrine (3H-NE) binding to the microsomal fraction of the rabbit aorta has been studied. Binding appears to increase linearly with time up to at least 30 min, shows no evidence of stereoselectivity and may be inhibited only by compounds possessing the catechol or 3-methoxy-4hydroxyphenyl moieties, with th... | A kinetic analysis of a catechol-specific binding site in the microsomal fraction from the rabbit aorta. (-)-3/-Norepinephrine (3H-NE) binding to the microsomal fraction of the rabbit aorta has been studied. Binding appears to increase linearly with time up to at least 30 min, shows no evidence of stereoselectivity and... | [
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PMID:8321 | Alpha-adrenergic activity of N,N-dimethyldopamine (DMDA). | The autonomic and cardiovascular activity of N,N-dimethyldopamine (DMDA) was studied in the dog and rabbit. DMDA appears to be a postganglionic sympathetic alpha-adrenoceptor agonist since it consistently caused vasconstriction in several isolated vascular beds, even in the presence of ganglionic blockade. The pressor ... | Alpha-adrenergic activity of N,N-dimethyldopamine (DMDA). The autonomic and cardiovascular activity of N,N-dimethyldopamine (DMDA) was studied in the dog and rabbit. DMDA appears to be a postganglionic sympathetic alpha-adrenoceptor agonist since it consistently caused vasconstriction in several isolated vascular beds,... | [
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PMID:8327 | Glycoprotein biosynthesis in splenic cells. Purification of a microsomal galactosyl-transferase. | One part of the microsomal galactosyl-transferase activity of splenic cells of rats can by solubilized by the action of Triton X-100 and Tween 20. Its purification on a Sephadex G-200 column and by electrophoresis on a polyacrylamide gel leads to a solution of high specific enzymic activity. | Glycoprotein biosynthesis in splenic cells. Purification of a microsomal galactosyl-transferase. One part of the microsomal galactosyl-transferase activity of splenic cells of rats can by solubilized by the action of Triton X-100 and Tween 20. Its purification on a Sephadex G-200 column and by electrophoresis on a poly... | [
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PMID:8329 | Beta-adrenergic blocking agents as potent antagonists of mescaline-induced contractions in the rat uterus. | In the isolated rat uterus, mescaline induces contractions that are notably antagonized by catecholamines, by beta-adrenergic stimulants and certain beta-adrenergic blocking agents as well as by chlorpromazine, amitriptyline and methysergide. | Beta-adrenergic blocking agents as potent antagonists of mescaline-induced contractions in the rat uterus. In the isolated rat uterus, mescaline induces contractions that are notably antagonized by catecholamines, by beta-adrenergic stimulants and certain beta-adrenergic blocking agents as well as by chlorpromazine, am... | [
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PMID:8330 | Influence of castration and testosterone replacement on hypothalamic tyrosine hydroxylase activity in the rat. | Hypothalamic tyrosine hydroxylase (TH) activity of castrate rats is modulated by testosterone propionate (TP) in vivo. Kinetic studies revealed that both Vmax and Km were virtually unaltered for substrate tyrosine in the presence of an excess of DMPH4 cofactor. TP replacement to castrate rats increased the Km for added... | Influence of castration and testosterone replacement on hypothalamic tyrosine hydroxylase activity in the rat. Hypothalamic tyrosine hydroxylase (TH) activity of castrate rats is modulated by testosterone propionate (TP) in vivo. Kinetic studies revealed that both Vmax and Km were virtually unaltered for substrate tyro... | [
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PMID:8341 | Effects of autonomic drugs on epididymal contractions. | The spontaneous contractility of rat epididymis was recorded in vivo and the effects of various autonomic drugs were studied. Norepinephrine, epinephrine, and orciprenaline produced a sudden increase in tonus and in the size and frequency of epididymal contractions. Phentolamine (an alpha-blocker agent) inhibited the e... | Effects of autonomic drugs on epididymal contractions. The spontaneous contractility of rat epididymis was recorded in vivo and the effects of various autonomic drugs were studied. Norepinephrine, epinephrine, and orciprenaline produced a sudden increase in tonus and in the size and frequency of epididymal contractions... | [
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PMID:8343 | [Studies of various factors in thyrotropoin releasing hromone TRH) radioimmunoassay for serum (author's transl)]. | To study the significance of TRH in the hypothalamo-pituitary-thyroid axis measurement of TRH in body fluid are needed. We previously reported TRH radioimmunoassay for urine. TRH radioimmunoassay for serum has not established yet, because TRH immunoreactivity is inactivated with serum. We investigated effects of variou... | [Studies of various factors in thyrotropoin releasing hromone TRH) radioimmunoassay for serum (author's transl)]. To study the significance of TRH in the hypothalamo-pituitary-thyroid axis measurement of TRH in body fluid are needed. We previously reported TRH radioimmunoassay for urine. TRH radioimmunoassay for serum ... | [
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PMID:8344 | [Cutaneous side effects of systemic drugs. Part 4 of a synopsis. 6/7. Drugs affecting the central nervous system. C. Drug-induced photosensitivity. D. Drug-induced changes of skin color]. | This, the fourth part of a synopisis of cutaneous side effects of drugs, covers the drugs affecting the central nervous system: antiepileptics, hypnotics, narcotics and psychopharmaceutics; the myorelaxants and antiallergics follow, and lastly there is a section on drug addiction and placebo. The various cutaneous side... | [Cutaneous side effects of systemic drugs. Part 4 of a synopsis. 6/7. Drugs affecting the central nervous system. C. Drug-induced photosensitivity. D. Drug-induced changes of skin color]. This, the fourth part of a synopisis of cutaneous side effects of drugs, covers the drugs affecting the central nervous system: anti... | [
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PMID:8356 | Gastric and extragastric gastrin release in normal subjects in duodenal ulcer patients, and in patients with partial gastrectomy (Billroth I). | In 10 normal subjects, in 32 patients with duodenal ulcer (DU), and in 11 patients with partial gastrectomy (Billroth I), serum gastrin rose significantly after an oral and intraduodenal test meal. The highest increases were observed in DU patients after the oral as well as after the intraduodenal test meal. After the ... | Gastric and extragastric gastrin release in normal subjects in duodenal ulcer patients, and in patients with partial gastrectomy (Billroth I). In 10 normal subjects, in 32 patients with duodenal ulcer (DU), and in 11 patients with partial gastrectomy (Billroth I), serum gastrin rose significantly after an oral and intr... | [
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PMID:8357 | Effects of carbenoxolone on gastric mucosal permeability and blood flow in the dog. | The effects of topical application of carbenoxolone at neutral and acidic pH were compared in exteriorized, chambered segments of canine gastric corpus. When dissolved in saline at pH 7.5 to 8.0, 0.25% carbenoxolone caused a rapid drop in gastric potential difference of 56 +/- 2 mv and greatly increased permeability to... | Effects of carbenoxolone on gastric mucosal permeability and blood flow in the dog. The effects of topical application of carbenoxolone at neutral and acidic pH were compared in exteriorized, chambered segments of canine gastric corpus. When dissolved in saline at pH 7.5 to 8.0, 0.25% carbenoxolone caused a rapid drop ... | [
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PMID:8360 | Recombinant clone heterogeneity in Escherichia coli conjunction: effect of pH and partially replicated recipient deoxyribonucleic acid. | At pH 6.8, a substantial fraction of recombinant colonies obtained from conjugation with an HfrH donor contained multiple recombinant classes in a single colony (polygenotype colony). In contrast, when the conjugation was performed at pH 7.6, the number of polygenotypic colonies was drastically reduced, and the recombi... | Recombinant clone heterogeneity in Escherichia coli conjunction: effect of pH and partially replicated recipient deoxyribonucleic acid. At pH 6.8, a substantial fraction of recombinant colonies obtained from conjugation with an HfrH donor contained multiple recombinant classes in a single colony (polygenotype colony). ... | [
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PMID:8361 | [Galenic studies of a new gastrotherapeutic drug]. | This paper presents the methods for galenical investigations of a new gastrotherapeutic preparation. The results and their possible relations to therapy are discussed. The preparation is presented a press-coated tablet. Its antacid characteristics concerning the rate of effectiveness, potency and duration are compared ... | [Galenic studies of a new gastrotherapeutic drug]. This paper presents the methods for galenical investigations of a new gastrotherapeutic preparation. The results and their possible relations to therapy are discussed. The preparation is presented a press-coated tablet. Its antacid characteristics concerning the rate o... | [
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PMID:8362 | [Field study on the decrease of lipids using etofibrate]. | A field-trial on Etofibrat was performed on 4405 patients suffering from primary and secondary hyperlipoproteinemia. The results were proved statistically. After a 3 to 4 weeks treatment the concentration of cholesterol as well as tryglicerides in the serum decreased significantly. After 6 to 8 weeks treatment the lipi... | [Field study on the decrease of lipids using etofibrate]. A field-trial on Etofibrat was performed on 4405 patients suffering from primary and secondary hyperlipoproteinemia. The results were proved statistically. After a 3 to 4 weeks treatment the concentration of cholesterol as well as tryglicerides in the serum decr... | [
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PMID:8364 | Plasma insulin concentration during physiological variations in immunoreactive plasma secretin. | The effect of endogenous and exogenous secretin on fasting plasma insulin and glucose concentrations in peripheral venous blood was studied. In 10 non-diabetic subjects intragastric instillation of 300 ml 0.1 mol/l hydrochloric acid increased the plasma secretin concentration significantly. This increment did not influ... | Plasma insulin concentration during physiological variations in immunoreactive plasma secretin. The effect of endogenous and exogenous secretin on fasting plasma insulin and glucose concentrations in peripheral venous blood was studied. In 10 non-diabetic subjects intragastric instillation of 300 ml 0.1 mol/l hydrochlo... | [
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PMID:8366 | Stability of the insoluble form of uridine kinase coupled to zn2+ or pb2+ ions. | Partially purified calf brain uridine kinase precipitated by bivalent metal cations has been compared with the soluble enzyme fraction regarding its stability in the presence of inactivating factors. The freeze-dried preparations of uridine kinase precipitaated by Pb2+ or Zn2+ ions, althouth enzymatically highly active... | Stability of the insoluble form of uridine kinase coupled to zn2+ or pb2+ ions. Partially purified calf brain uridine kinase precipitated by bivalent metal cations has been compared with the soluble enzyme fraction regarding its stability in the presence of inactivating factors. The freeze-dried preparations of uridine... | [
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PMID:8367 | [Effect of 2-hydroxyestradiol-17beta on NADPH-dependent electron transfer in rat liver microsomes in vitro (author's transl)]. | If rat liver microsomes are incubated with NADPH and 2-hydroxyestradiol-17beta in vitro, the following is observed: 1. Inhibition of lipid peroxidation, 2.inhibition of cytochrome P-450 reduction, and 3.inhibition of cytochrome b5 reduction. Beyond this the catechole inhibits lipid peroxidation of liposomes in vitro. T... | [Effect of 2-hydroxyestradiol-17beta on NADPH-dependent electron transfer in rat liver microsomes in vitro (author's transl)]. If rat liver microsomes are incubated with NADPH and 2-hydroxyestradiol-17beta in vitro, the following is observed: 1. Inhibition of lipid peroxidation, 2.inhibition of cytochrome P-450 reducti... | [
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PMID:8368 | Purification and characterisation of four polypeptides with neurotoxic activity from Condylactis aurantiaca. | Four toxic polypeptides, Toxins I, II, III and IV were isolated in pure form from the sea anemone Condylactis aurantiaca (Actinaria). Toxin isolation was achieved by alcoholic extraction of the homogenised sea anemones, batchwise adsorption onto cation exchangers, gel filtration on Sephadex G-50 and G-25 and ion-exchan... | Purification and characterisation of four polypeptides with neurotoxic activity from Condylactis aurantiaca. Four toxic polypeptides, Toxins I, II, III and IV were isolated in pure form from the sea anemone Condylactis aurantiaca (Actinaria). Toxin isolation was achieved by alcoholic extraction of the homogenised sea a... | [
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PMID:8370 | Hydrolysis-resynthesis equilibrium of the lysine-15--alanine-16 peptide bond in bovine trypsin inhibitor (Kunitz). | Catalytic amounts of bovine beta-trypsin, bovine alpha-chymotrypsin and porcine plasmin establish a true thermodynamic equilibrium between virgin (I) (reactive site Lys15-Ala16 peptide bond intact) and modified (I) (this bond hydrolyzed) bovine trypsin/kallikrein inhibitor (Kunitz). The very slow reaction rates for att... | Hydrolysis-resynthesis equilibrium of the lysine-15--alanine-16 peptide bond in bovine trypsin inhibitor (Kunitz). Catalytic amounts of bovine beta-trypsin, bovine alpha-chymotrypsin and porcine plasmin establish a true thermodynamic equilibrium between virgin (I) (reactive site Lys15-Ala16 peptide bond intact) and mod... | [
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PMID:8378 | Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. I. Selection in the mouse thymus of killer and helper cells. | In the present study we have investigated the biological effects on thymus lymphocytes resulting from Escherichia coli lipopolysaccharide (LPS) treatment in young adult mice. It has been established that LPS induces the following effects: (a) a dose-dependent reduction of thymus weight contemporaneous with a rise in th... | Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. I. Selection in the mouse thymus of killer and helper cells. In the present study we have investigated the biological effects on thymus lymphocytes resulting from Escherichia coli lipopolysaccharide (LPS) treatment in young adult mice. It has been... | [
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PMID:8381 | Fertility control with sub-dermal silastic capsules containing a new progestin (ST-1435). | The contraceptive action of silastic implants containing a new progestion ST-1435 was investigated in 285 women of reproductive age. A group of 52 women (group A) received three capsules containing each 35 mg of the steroid. A second group of 48 women (group B) received four capsules and a third and larger group of 185... | Fertility control with sub-dermal silastic capsules containing a new progestin (ST-1435). The contraceptive action of silastic implants containing a new progestion ST-1435 was investigated in 285 women of reproductive age. A group of 52 women (group A) received three capsules containing each 35 mg of the steroid. A sec... | [
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PMID:8382 | Human semen ribonuclease. Location, properties and inhibition by sodium dodecyl sulfate, zinc sulfate and EDTA. | Optimal conditions were established for RNase activity measurement. The enzyme was measured in human seminal plasma as well as in spermatozoa. Results suggest that sperm enzyme may come from seminal plasma contamination and that RNase may be used as a marker enzyme for seminal plasma contamination. Sodium dodecylsulfat... | Human semen ribonuclease. Location, properties and inhibition by sodium dodecyl sulfate, zinc sulfate and EDTA. Optimal conditions were established for RNase activity measurement. The enzyme was measured in human seminal plasma as well as in spermatozoa. Results suggest that sperm enzyme may come from seminal plasma co... | [
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PMID:8383 | Lack of effects of testosterone on norepinephrine turnover and tyrosine hydroxylase activity of the rat vas deferens and epididymis. | To test the effects of testosterone on some aspects of the metabolism of norepinephrine (NE) in short adrenergic neurons of the male genital tract, orchiectomized rats received 500 mug of testosterone propionate twice daily for up to 18 days. Androgen treatment did not affect the levels, uptake or efflux of NE nor modi... | Lack of effects of testosterone on norepinephrine turnover and tyrosine hydroxylase activity of the rat vas deferens and epididymis. To test the effects of testosterone on some aspects of the metabolism of norepinephrine (NE) in short adrenergic neurons of the male genital tract, orchiectomized rats received 500 mug of... | [
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PMID:8384 | Fifteen years experience with artificial insemination. | Artificial insemination is today an accepted procedure in circumventing sterility. In recent years this procedure gained much popularity as the number of infants available for adoption steadily decreased due to the liberal abortion laws. A review of 15 years of practiced experience (senior author) is presented. In all ... | Fifteen years experience with artificial insemination. Artificial insemination is today an accepted procedure in circumventing sterility. In recent years this procedure gained much popularity as the number of infants available for adoption steadily decreased due to the liberal abortion laws. A review of 15 years of pra... | [
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PMID:8385 | Reversible anti-fertility effect by non-occluding oviductal copper coils in the rabbit. | Placement of two 1 cm copper (Cu) coils around the mid-region of each oviduct in a group of five female rabbits with proven fertility, 34 days before mating, virtually prevented fetal implantation in these animals. The oviducts remained patent during a 47 day implantation period and following removal of the Cu coils, d... | Reversible anti-fertility effect by non-occluding oviductal copper coils in the rabbit. Placement of two 1 cm copper (Cu) coils around the mid-region of each oviduct in a group of five female rabbits with proven fertility, 34 days before mating, virtually prevented fetal implantation in these animals. The oviducts rema... | [
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PMID:8386 | The effect of exogenous gondadotropins on the pre-implantation period in the rat. | It is well established that the egg implantation in the rat is dependent on a surge of gonadotropin secretion on day 4 of pregnancy. The present experiments were designed in order to demonstrate the possible effect of exogenous administration of gonadotropins during pre-implantation period in pseudopregnant rats, made ... | The effect of exogenous gondadotropins on the pre-implantation period in the rat. It is well established that the egg implantation in the rat is dependent on a surge of gonadotropin secretion on day 4 of pregnancy. The present experiments were designed in order to demonstrate the possible effect of exogenous administra... | [
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PMID:8387 | Case report: sterility due to sperm autoagglutination. | Autoagglutination in seminal fluid of husbands in three unexplained sterile couples was found in routine semen-analysis. Further exploration showed that sera and seminal fluid of these husbands agglutinate donors' sperm, while their wives' sera did not. Post-coital tests were not significant. After failure of conservat... | Case report: sterility due to sperm autoagglutination. Autoagglutination in seminal fluid of husbands in three unexplained sterile couples was found in routine semen-analysis. Further exploration showed that sera and seminal fluid of these husbands agglutinate donors' sperm, while their wives' sera did not. Post-coital... | [
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PMID:8388 | Distribution and removal of the acrosin of bull spermatozoa. | The effects of Hyamine 2389, Triton X-100, Nadeoxycholate, acetic acid and hypertonic KCl and MgCl2 as well as freezing and thawing and sonication were studied on the solubilization of acrosin from washed bull spermatozoa, from Hyamine-pretreated spermatozoa (devoid of cell and outer acrosome membrane and of acrosomal ... | Distribution and removal of the acrosin of bull spermatozoa. The effects of Hyamine 2389, Triton X-100, Nadeoxycholate, acetic acid and hypertonic KCl and MgCl2 as well as freezing and thawing and sonication were studied on the solubilization of acrosin from washed bull spermatozoa, from Hyamine-pretreated spermatozoa ... | [
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PMID:8389 | The effect of prostaglandins F1 alpha and F2 alpha on spermatogenesis. | The effect of the prostaglandins F1 alpha and F2 alpha on spermatogenesis in the mature male mouse has been studied. Administration of prostaglandins F1 alpha and F2 alpha subcutaneously at a dose of 3 mg/kg once a day for 15 days produced a pronounced decrease in spermatogenesis primarily during the meiotic phase as r... | The effect of prostaglandins F1 alpha and F2 alpha on spermatogenesis. The effect of the prostaglandins F1 alpha and F2 alpha on spermatogenesis in the mature male mouse has been studied. Administration of prostaglandins F1 alpha and F2 alpha subcutaneously at a dose of 3 mg/kg once a day for 15 days produced a pronoun... | [
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PMID:8390 | Immunological factors and post coital test in unexplained infertility. | Twenty-four couples facing longstanding primary or secondary infertility underwent semen analysis, PCT, functional evaluation of menstrual cycle, hysterosalpingography and laparscopy. All clinical findings were normal with the exception of PCT which was positive in 13 and negative in 11. All the women underwent a multi... | Immunological factors and post coital test in unexplained infertility. Twenty-four couples facing longstanding primary or secondary infertility underwent semen analysis, PCT, functional evaluation of menstrual cycle, hysterosalpingography and laparscopy. All clinical findings were normal with the exception of PCT which... | [
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PMID:8391 | Pituitary and testicular response to hypothalamic LH-releasing hormone (LH-RH) in normal and oligospermic men. | A comparative study was done of the basal and post-LH-RH stimulation levels of LH, FSH and Testosterone (T) in 10 healthy, male volunteers, aged 24-35 years, and in 25 normogonadotropic oligospermic men aged 23-43 years in whom other endocrine, urologic and/or vascular diseases had been rules out. Seventeen of the latt... | Pituitary and testicular response to hypothalamic LH-releasing hormone (LH-RH) in normal and oligospermic men. A comparative study was done of the basal and post-LH-RH stimulation levels of LH, FSH and Testosterone (T) in 10 healthy, male volunteers, aged 24-35 years, and in 25 normogonadotropic oligospermic men aged 2... | [
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PMID:8394 | Alkaline phosphatase, arylsulfatase and beta-glucuronidase in saliva of cyclic women. | Levels of the enzymes alkaline phosphatase, arylsulfatase, and beta-glucuronidase have been measured in whole unstimulated saliva samples collected daily during normal menstrual cycles. The cellular content of the saliva has been shown to be a major source of the three enzymes. The enzymes were found to have peak maxim... | Alkaline phosphatase, arylsulfatase and beta-glucuronidase in saliva of cyclic women. Levels of the enzymes alkaline phosphatase, arylsulfatase, and beta-glucuronidase have been measured in whole unstimulated saliva samples collected daily during normal menstrual cycles. The cellular content of the saliva has been show... | [
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PMID:8395 | A new model for antisperm autoimmunity in guine pigs. | Adult outbread male guinea pigs were autoimmunized without adjuvant. Homogenates were prepared with one of their own testes previously submitted "in vivo" and "in vitro" to thermal injury. Animals received a single or daily repeated intradermal injection without added adjuvant, in one or different skin sites. Guinea pi... | A new model for antisperm autoimmunity in guine pigs. Adult outbread male guinea pigs were autoimmunized without adjuvant. Homogenates were prepared with one of their own testes previously submitted "in vivo" and "in vitro" to thermal injury. Animals received a single or daily repeated intradermal injection without add... | [
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PMID:8397 | Quantitative study of spermatogenesis in vasectomized mice. | Adult mice were vasectomized under semi-sterile conditions and examined five weeks later. The weight of the epididymis was increased but none of the animals had developed spermatic granulomas. The concentration of testosterone in the plasma, the body weight and the weight of the testes were not affected by vasectomy. C... | Quantitative study of spermatogenesis in vasectomized mice. Adult mice were vasectomized under semi-sterile conditions and examined five weeks later. The weight of the epididymis was increased but none of the animals had developed spermatic granulomas. The concentration of testosterone in the plasma, the body weight an... | [
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PMID:8398 | Fertility patterns in female mice following treatment with arginine vastocin or melatonin. | Daily injections of either 2 mug arginine vasotocin (AVT) or 100 mug melatonin significantly prolonged the estrous cycles of mature female mice. If administered daily throughout pregnancy, none of the AVT-treated mice delivered viable pups. | Fertility patterns in female mice following treatment with arginine vastocin or melatonin. Daily injections of either 2 mug arginine vasotocin (AVT) or 100 mug melatonin significantly prolonged the estrous cycles of mature female mice. If administered daily throughout pregnancy, none of the AVT-treated mice delivered v... | [
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PMID:8399 | The pH dependence of binding of alpha,alpha'-dibromo-p-xylenesulfonic acid to lysozyme. | The chemical modification of lysozyme (I) has been accomplished with alpha, alpha'-dibromo-p-xylenesulfonic acid (DBX) at five different pH values. I was alkylated by DBX at room temperature (28 degrees C) with decrease in enzyme activity. The rate of inactivation depended upon the pH at which alkylation was carried ou... | The pH dependence of binding of alpha,alpha'-dibromo-p-xylenesulfonic acid to lysozyme. The chemical modification of lysozyme (I) has been accomplished with alpha, alpha'-dibromo-p-xylenesulfonic acid (DBX) at five different pH values. I was alkylated by DBX at room temperature (28 degrees C) with decrease in enzyme ac... | [
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PMID:8400 | Complete enzymic digestion of acidic proteins. | Acidic proteins are usually resistant to complete enzymic hydrolysis. The increasing number of "unusual" amino acids, which are unstable to acid hydrolysis, makes it necessary to have a method of enzymic hydrolysis applicable to all proteins. The complete hydrolysis of four acidic proteins by subtilisin plus leucine am... | Complete enzymic digestion of acidic proteins. Acidic proteins are usually resistant to complete enzymic hydrolysis. The increasing number of "unusual" amino acids, which are unstable to acid hydrolysis, makes it necessary to have a method of enzymic hydrolysis applicable to all proteins. The complete hydrolysis of fou... | [
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PMID:8401 | Interpretation and applications of thermal difference spectra of proteins. | The technique of thermal perturbation difference spectroscopy for examining chromophores in proteins has been set on a more acceptable theoretical and experimental foundation. (i) The origins of the thermal effect have been analysed to explain changes in spectral band width and wavelength for simple chromophores in var... | Interpretation and applications of thermal difference spectra of proteins. The technique of thermal perturbation difference spectroscopy for examining chromophores in proteins has been set on a more acceptable theoretical and experimental foundation. (i) The origins of the thermal effect have been analysed to explain c... | [
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0.03325... |
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