id stringlengths 7 10 | title stringlengths 8 354 | content stringlengths 91 4.1k | contents stringlengths 164 4.24k | embedding listlengths 384 384 |
|---|---|---|---|---|
PMID:7370 | Determination of oxalic acid in urine by atomic absorption spectrophotometry. | A method is described for determination of oxalic acid in urine using atomic absorption spectrophotometry. The concentration of urinary oxalic acid is calculated by using the difference between two determinations of calcium: first, the excess of calcium in the supernatant after precipitation as calcium oxalate at pH 5,... | Determination of oxalic acid in urine by atomic absorption spectrophotometry. A method is described for determination of oxalic acid in urine using atomic absorption spectrophotometry. The concentration of urinary oxalic acid is calculated by using the difference between two determinations of calcium: first, the excess... | [
-0.02867955155670643,
0.027168799191713333,
-0.0061039067804813385,
-0.023666871711611748,
0.004381086211651564,
-0.03487907350063324,
0.11848421394824982,
0.07135096937417984,
-0.037881530821323395,
0.013659879565238953,
0.05623048171401024,
-0.14466741681098938,
0.057340141385793686,
0.0... |
PMID:7371 | Assessment of the functional activity of human lymphocytes in malignant disease by the local graft-versus-host reaction in rats and the T rosette-forming cell test. | The local graft-versus-host reaction (GVHR) and the spontaneous rosette-forming cell (RFC) test were used to test the functional activity of lymphocytes in blood obtained from twenty normal donors and thirty patients with malignant tumours. The lymphocytes of all twenty control donors gave a positive GVHR and had norma... | Assessment of the functional activity of human lymphocytes in malignant disease by the local graft-versus-host reaction in rats and the T rosette-forming cell test. The local graft-versus-host reaction (GVHR) and the spontaneous rosette-forming cell (RFC) test were used to test the functional activity of lymphocytes in... | [
-0.027427904307842255,
0.0027961123269051313,
-0.014748504385352135,
0.04667745158076286,
0.04255629703402519,
-0.022998875007033348,
0.10667221248149872,
0.09441407769918442,
-0.03795810416340828,
-0.027123484760522842,
-0.00419428339228034,
-0.061327915638685226,
0.019423026591539383,
0.... |
PMID:7373 | Plasma levels and effects of metoprolol on blood pressure, adrenergic beta receptor blockade, and plasma renin activity in essential hypertension. | The effects of metoprolol, a selective beta adrenergic receptor antagonist, on blood pressure, beta receptor blockade (antagoinst of isoproterenol and exercise tachycardia), and plasma renin activity (PRA) have been compared with those of placebo in 16 patients with essential hypertension. The dose of metroprolol was 2... | Plasma levels and effects of metoprolol on blood pressure, adrenergic beta receptor blockade, and plasma renin activity in essential hypertension. The effects of metoprolol, a selective beta adrenergic receptor antagonist, on blood pressure, beta receptor blockade (antagoinst of isoproterenol and exercise tachycardia),... | [
-0.05078976973891258,
0.022491488605737686,
0.02329135127365589,
0.021456973627209663,
-0.00970388576388359,
-0.03146743029356003,
0.010356870479881763,
0.006305641029030085,
-0.028106290847063065,
-0.05201857537031174,
0.004155996721237898,
-0.023352976888418198,
-0.016720127314329147,
0.... |
PMID:7374 | Effects of prazosin in patients with hypertension. | A double-blind placebo crossover trail (2 periods, each of 6 wk) was carried out in 12 patients. In the first period the patients were randomly allocated to either their individual established dose of prazosin or to the same number of placebo tablets; treatment was reversed after 6 wk. Blood pressure was higher by 17/8... | Effects of prazosin in patients with hypertension. A double-blind placebo crossover trail (2 periods, each of 6 wk) was carried out in 12 patients. In the first period the patients were randomly allocated to either their individual established dose of prazosin or to the same number of placebo tablets; treatment was rev... | [
-0.04521467536687851,
-0.0007366943173110485,
-0.0011841380037367344,
0.03304462879896164,
0.0028635088820010424,
-0.002206371631473303,
0.0662740170955658,
0.023180872201919556,
-0.04809679463505745,
-0.05473208427429199,
0.0007952942396514118,
0.005985975731164217,
-0.02448127791285515,
... |
PMID:7375 | Blood levels and electroencephalographic effects of diazepam and bromazepam. | Blood levels and electroencephalographic (EEG) data were collected for 2 hr after single oral doses of bromazepam (9 mg), diazepam (10 mg), and placebo in 13 male adult volunteers. Both drugs caused an increase in beta activity (above 13 Hz) and a decrease in alpha activity (9 to 11 Hz) in the EEG. Blood levels of 100 ... | Blood levels and electroencephalographic effects of diazepam and bromazepam. Blood levels and electroencephalographic (EEG) data were collected for 2 hr after single oral doses of bromazepam (9 mg), diazepam (10 mg), and placebo in 13 male adult volunteers. Both drugs caused an increase in beta activity (above 13 Hz) a... | [
-0.03029615618288517,
-0.009120202623307705,
0.023185202851891518,
0.014690181240439415,
0.008963613770902157,
0.03377507999539375,
0.056330300867557526,
0.04518905282020569,
-0.011551841162145138,
-0.039683643728494644,
-0.014181571081280708,
-0.01934545859694481,
-0.01574782095849514,
0.... |
PMID:7376 | The influence of food on nitrofurantoin bioavailability. | The effect of food on the absorption of five commercial dosage forms of nitrofurantoin varying widely in drug release and dissolution characteristics was assessed in man after oral administration. Four healthy fasting and nonfasting male subjects received, in a crossover fashion, a single 100-mg dose of microcrystallin... | The influence of food on nitrofurantoin bioavailability. The effect of food on the absorption of five commercial dosage forms of nitrofurantoin varying widely in drug release and dissolution characteristics was assessed in man after oral administration. Four healthy fasting and nonfasting male subjects received, in a c... | [
-0.016347957774996758,
0.020634107291698456,
-0.010552974417805672,
-0.03723292425274849,
0.019100043922662735,
0.0073724244721233845,
0.06878063082695007,
0.023696208372712135,
-0.08395346254110336,
-0.021381091326475143,
-0.009289759211242199,
-0.03605348616838455,
0.033387623727321625,
... |
PMID:7377 | Tricyclic antidepressant overdosage: experimental studies on the management of circulatory complications. | Tricyclic antidepressant overdosage may be complicated by cardiac arrhythmias, which were sometimes difficult to treat prior to the use of sodium bicarbonate. Experiments have been done with several antiarrhythmics in an attempt to define the optimum treatment. Sodium bicarbonate proved the most effective experimentall... | Tricyclic antidepressant overdosage: experimental studies on the management of circulatory complications. Tricyclic antidepressant overdosage may be complicated by cardiac arrhythmias, which were sometimes difficult to treat prior to the use of sodium bicarbonate. Experiments have been done with several antiarrhythmics... | [
-0.07851295173168182,
0.08147650957107544,
-0.02457514777779579,
0.04526941850781441,
-0.01726323552429676,
-0.04780349135398865,
0.001456080935895443,
0.01561130303889513,
-0.031131096184253693,
-0.0854920819401741,
-0.007673827465623617,
-0.05188233032822609,
0.009862343780696392,
0.0496... |
PMID:7385 | Synaptic transmission from photoreceptors to bipolar and horizontal cells in the carp retina. | The most important observations in the present study can be summarized as follows: 1. In horizontal and bipolar cells, blocking chemical transmission caused membrane potential changes of the same polarity as the responses to illumination in each cell type. 2. Acceleration of transmitter release from the receptor termin... | Synaptic transmission from photoreceptors to bipolar and horizontal cells in the carp retina. The most important observations in the present study can be summarized as follows: 1. In horizontal and bipolar cells, blocking chemical transmission caused membrane potential changes of the same polarity as the responses to i... | [
-0.019051963463425636,
-0.026863256469368935,
0.021302323788404465,
0.003926405217498541,
-0.00982536468654871,
0.012346979230642319,
0.08081769943237305,
0.03153536841273308,
-0.028280600905418396,
-0.0187514740973711,
0.04502991586923599,
-0.09031856805086136,
0.0045501007698476315,
0.05... |
PMID:7432 | Anxiety therapy in the neoplastic patient. | A clinical study was carried out in 73 neoplastic patients suffering from anxiety and other emotional upsets to assess the effectiveness and tolerance of lorazepam. Patients were given individualised daily doses ranging from 1.5 mg to 3 mg lorazepam for 15 to 60 days. Results, as assessed by the response of anxiety, t... | Anxiety therapy in the neoplastic patient. A clinical study was carried out in 73 neoplastic patients suffering from anxiety and other emotional upsets to assess the effectiveness and tolerance of lorazepam. Patients were given individualised daily doses ranging from 1.5 mg to 3 mg lorazepam for 15 to 60 days. Results... | [
0.0010605496354401112,
0.008319665677845478,
0.06734692305326462,
0.027209104970097542,
-0.005652965046465397,
-0.011721939779818058,
0.07806496322154999,
-0.0027142930775880814,
-0.0073412819765508175,
-0.07266709953546524,
0.03752399981021881,
0.01866883970797062,
-0.0029719979502260685,
... |
PMID:7438 | Transport of ions and water across the epithelium of fish gills. | The teleostean gill is characterized by an exceptionally low permeability to water. Water moves along the osmotic gradient across the gill, being gained in fresh water and lost in sea water. Coupling of water movement to solute movement has not been reported. In fresh water, the gill is the site of independent active u... | Transport of ions and water across the epithelium of fish gills. The teleostean gill is characterized by an exceptionally low permeability to water. Water moves along the osmotic gradient across the gill, being gained in fresh water and lost in sea water. Coupling of water movement to solute movement has not been repor... | [
-0.08064799755811691,
-0.06826842576265335,
-0.016546422615647316,
0.038264207541942596,
0.017061103135347366,
-0.06740141659975052,
0.061695244163274765,
0.018513960763812065,
-0.03604442998766899,
-0.04674938693642616,
0.026419226080179214,
-0.15138915181159973,
-0.011309513822197914,
-0... |
PMID:7439 | Coupling of water to solute movement in isolated gastric mucosa. | Osmosis is apparently the mechanism responsible for the coupling of water to solute transport in biological membranes. Often a secreted or absorbed fluid is essentially iso-osmotic with the solution of origin, or with plasma, and various models have been constructed by Curran, Diamond and others to account for such obs... | Coupling of water to solute movement in isolated gastric mucosa. Osmosis is apparently the mechanism responsible for the coupling of water to solute transport in biological membranes. Often a secreted or absorbed fluid is essentially iso-osmotic with the solution of origin, or with plasma, and various models have been ... | [
-0.009015008807182312,
-0.04710324481129646,
0.0025072507560253143,
-0.00022111510043032467,
0.010703589767217636,
-0.0562368668615818,
0.0050711967051029205,
0.007265299092978239,
0.02744399383664131,
-0.03662748262286186,
-0.02984388917684555,
-0.1216757595539093,
-0.003660242771729827,
... |
PMID:7440 | Ion transport across amphibian lung. | The simple architecture of the amphibian lung makes it possible to study the movement of substances across a barrier with permeability and bioelectric properties that are dominated by the alveolar epithelium. When mounted as a planar sheet between identical Ringer solutions the excised lung of the bullfrog exhibited a ... | Ion transport across amphibian lung. The simple architecture of the amphibian lung makes it possible to study the movement of substances across a barrier with permeability and bioelectric properties that are dominated by the alveolar epithelium. When mounted as a planar sheet between identical Ringer solutions the exci... | [
-0.03519156575202942,
-0.047689467668533325,
0.0019452919950708747,
0.02840503118932247,
0.00028869317611679435,
-0.016226209700107574,
0.05686520040035248,
0.0019190221792086959,
-0.013882316648960114,
0.0116462092846632,
0.0011954883811995387,
-0.13543576002120972,
0.005627190228551626,
... |
PMID:7441 | Ion transport and water flow in the mammalian lung. | The coupling of bulk water flow to active ion transport has been described in various epithelia; evidence presented here suggests that this is also a feature of the mammalian lung. Measurements of the ionic composition of lung liquid and its rate of formation in the fetal lamb in vivo have made it possible to estimate ... | Ion transport and water flow in the mammalian lung. The coupling of bulk water flow to active ion transport has been described in various epithelia; evidence presented here suggests that this is also a feature of the mammalian lung. Measurements of the ionic composition of lung liquid and its rate of formation in the f... | [
-0.054673932492733,
-0.042931973934173584,
-0.010503825731575489,
0.04440484195947647,
0.00866525899618864,
-0.01785927079617977,
0.10507940500974655,
0.008011618629097939,
-0.0009688170393928885,
0.038966961205005646,
-0.03901926428079605,
-0.1531374156475067,
-0.020109593868255615,
0.000... |
PMID:7442 | Lung carbonate dehydratase (carbonic anhydrase), CO2 stores and CO2 transport. | A study of CO2 storage in excised, exsanguinated lungs revealed that CO2 stores include a compartment which reaches equilibration very rapidly (less than 3s) and a slower compartment which equilibrates with a half-time of approximately 15 s. Inhibition of carbonate dehydratase (carbonic anhydrase, EC 4.2.1.1) does not ... | Lung carbonate dehydratase (carbonic anhydrase), CO2 stores and CO2 transport. A study of CO2 storage in excised, exsanguinated lungs revealed that CO2 stores include a compartment which reaches equilibration very rapidly (less than 3s) and a slower compartment which equilibrates with a half-time of approximately 15 s.... | [
-0.08745545893907547,
0.0030310836154967546,
0.020796429365873337,
0.07180000841617584,
0.01588546857237816,
-0.025440368801355362,
0.07040397077798843,
-0.005261522252112627,
-0.039543453603982925,
0.025913693010807037,
0.039216890931129456,
-0.0738055631518364,
-0.027839066460728645,
0.0... |
PMID:7446 | Prolactin-releasing and release-inhibiting factor activities in the bovine, rat, and human pineal gland: in vitro and in vivo studies. | The effects of crude extracts of bovine, rat, and human pineal glands on prolactin (PRL) release were studied using an in vitro system. In addition, the effects of a known pineal constituent, arginine vasotocin (AVT), and crude bovine pineal extract (bPE) on PRL secretion were studied in vivo. Normal male rat hemipitui... | Prolactin-releasing and release-inhibiting factor activities in the bovine, rat, and human pineal gland: in vitro and in vivo studies. The effects of crude extracts of bovine, rat, and human pineal glands on prolactin (PRL) release were studied using an in vitro system. In addition, the effects of a known pineal consti... | [
-0.011400924064218998,
0.01752881146967411,
-0.012531494721770287,
-0.015352764166891575,
0.08750347793102264,
0.005250981077551842,
0.026525147259235382,
-0.001058838446624577,
0.023831438273191452,
-0.03583278879523277,
-0.020235955715179443,
-0.06314106285572052,
-0.02742195501923561,
0... |
PMID:7447 | Adenylyl cyclase activities in ovarian tissues. I. Homogenization and conditions of assay in graafian follicles and corpora lutea of rabbits, rats, and pigs: regulation by ATP, and some comparative properties. | Responsiveness of ovarian adenylyl cyclases to luteinizing hormone (LH), found to be 5 to 10-fold in cell-free preparations under optimal conditions, required gentle homogenizations and storage in sucrose-containing media. Assay conditions required the use of an ATP-regenerating system consisting of creatine kinase, cr... | Adenylyl cyclase activities in ovarian tissues. I. Homogenization and conditions of assay in graafian follicles and corpora lutea of rabbits, rats, and pigs: regulation by ATP, and some comparative properties. Responsiveness of ovarian adenylyl cyclases to luteinizing hormone (LH), found to be 5 to 10-fold in cell-free... | [
-0.008582771755754948,
-0.04227226972579956,
-0.021649176254868507,
0.05288286879658699,
0.01859287917613983,
-0.019994650036096573,
0.023201260715723038,
0.040277909487485886,
-0.0319124311208725,
-0.005457028280943632,
0.05033614858984947,
-0.08958201110363007,
0.004006657749414444,
0.03... |
PMID:7449 | Further observations on the properties of serum and tissue guanase from man and some animal species. Optimum pH and activation energy in the presence of 8-azaguanine. | The activation energy and the optimum pH of guanine deaminase in man, the rat, guinea pig and mouse were studied using 8-azaguanine as a substrate. The serum guanase in man and in all the animal species studied differs in activation energy from the guanase of the liver. In man, moreover, the serum guanase is also diffe... | Further observations on the properties of serum and tissue guanase from man and some animal species. Optimum pH and activation energy in the presence of 8-azaguanine. The activation energy and the optimum pH of guanine deaminase in man, the rat, guinea pig and mouse were studied using 8-azaguanine as a substrate. The s... | [
-0.034047797322273254,
0.02012074925005436,
0.01828603819012642,
0.03146073594689369,
0.042229797691106796,
0.040478866547346115,
0.11844489723443985,
0.041055407375097275,
-0.03483957424759865,
-0.006692351307719946,
-0.006050796713680029,
-0.09009385854005814,
-0.07394760847091675,
0.035... |
PMID:7450 | Control of fatty-acid synthetase levels by exogeneous long-chain fatty acids in the yeasts Candida lipolytica and Saccharomyces cerevisiae. | Endogeneous fatty acid biosynthesis in the two yeast species, Saccharomyces cerevisiae and Candida lipolytica is completely repressed by the addition of long-chain fatty acids to the growth medium. In Candida lipolytica, this repression is accompanied by a corresponding loss of fatty acid synthetase activity in the cel... | Control of fatty-acid synthetase levels by exogeneous long-chain fatty acids in the yeasts Candida lipolytica and Saccharomyces cerevisiae. Endogeneous fatty acid biosynthesis in the two yeast species, Saccharomyces cerevisiae and Candida lipolytica is completely repressed by the addition of long-chain fatty acids to t... | [
-0.0435318686068058,
0.014825981110334396,
-0.016903379932045937,
0.04992378503084183,
-0.028583630919456482,
-0.014280548319220543,
-0.026700973510742188,
0.022768273949623108,
-0.0274365097284317,
0.04332512617111206,
0.02477416582405567,
-0.0940636545419693,
0.0016678028041496873,
-0.06... |
PMID:7451 | Calorimetric study on human erythrocyte glycolysis. Heat production in various metabolic conditions. | The heat production of human erythrocytes was measured on a flow microcalorimeter with simultaneous analyses of lactate and other metabolites. The heat production connected with the lactate formation was about 17 kcal (71 kJ) per mol lactate formed which corresponded to the sum of heat production due to the formation o... | Calorimetric study on human erythrocyte glycolysis. Heat production in various metabolic conditions. The heat production of human erythrocytes was measured on a flow microcalorimeter with simultaneous analyses of lactate and other metabolites. The heat production connected with the lactate formation was about 17 kcal (... | [
-0.04437479004263878,
0.004172249231487513,
0.028043102473020554,
0.03415408357977867,
0.02875172719359398,
-0.006982628721743822,
0.010564061813056469,
0.00933015625923872,
-0.035652805119752884,
-0.016468793153762817,
0.01841071993112564,
-0.08604522794485092,
-0.01619541086256504,
0.044... |
PMID:7452 | Studies of glutamate dehydrogenase. Regulation of glutamate dehydrogenase from Candida utilis by a pH and temperature-dependent conformational transition. | Glutamate dehydrogenase from Candida utilis undergoes a reversible conformational transition between an active and an inactive state at low pH AND low temperature. This conformational transition can also be followed by fluorescence measurements. The temperature-dependent equilibrium between the active and the inactive ... | Studies of glutamate dehydrogenase. Regulation of glutamate dehydrogenase from Candida utilis by a pH and temperature-dependent conformational transition. Glutamate dehydrogenase from Candida utilis undergoes a reversible conformational transition between an active and an inactive state at low pH AND low temperature. T... | [
-0.04850451275706291,
0.007619841955602169,
-0.01108326856046915,
0.03997340798377991,
0.04080464318394661,
0.012810035608708858,
0.0519716776907444,
0.03699231147766113,
-0.01641223393380642,
-0.023294106125831604,
0.02723381482064724,
-0.07071839272975922,
0.030426668003201485,
0.0034919... |
PMID:7453 | A spectroscopic investigation of S-trifluoroethylthiopapain. An investigation of the active site of papain. | The pH dependence of the 19F chemical shift and the fluorescence spectrum of S-2,2,2-trifluoro-1,1-dideuteroethyl-thio-paapain are analysed in terms of dependence on the ionisation of aspartic-acid-158 and histidine-159. The 19F probe causes negative cooperativity between these groups, and does not detected any ionisat... | A spectroscopic investigation of S-trifluoroethylthiopapain. An investigation of the active site of papain. The pH dependence of the 19F chemical shift and the fluorescence spectrum of S-2,2,2-trifluoro-1,1-dideuteroethyl-thio-paapain are analysed in terms of dependence on the ionisation of aspartic-acid-158 and histid... | [
-0.07307903468608856,
-0.00270666042342782,
-0.07100065797567368,
0.018847661092877388,
0.03171701729297638,
-0.005407564342021942,
0.08085449784994125,
0.016964463517069817,
-0.030001752078533173,
-0.0006075691198930144,
0.0295251477509737,
-0.07168080657720566,
0.033954937011003494,
0.04... |
PMID:7454 | Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycinemax). | A cinnamoyl-coenzyme A reductase catalyzing the NADPH-dependent reduction of substituted cinnamoyl-CoA thiol esters to the corresponding cinnamaldehydes was isolated from cell suspension cultures of soybean (Glycine max L. var. Mandarin). A 1660-fold purification of the enzyme was achieved by (NH4)2SO4 fractionation, c... | Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycinemax). A cinnamoyl-coenzyme A reductase catalyzing the NADPH-dependent reduction of substituted cinnamoyl-CoA thiol esters to the corresponding cinnamaldehydes was isol... | [
-0.039291419088840485,
-0.006685578729957342,
-0.07636696100234985,
0.020841030403971672,
0.07879777252674103,
-0.021786240860819817,
0.0031167087145149708,
-0.02940518967807293,
-0.055780310183763504,
-0.02119145728647709,
0.007267098408192396,
-0.06655571609735489,
0.009043657220900059,
... |
PMID:7455 | Interconversion between 17 beta-hydroxy-5alpha-androstan-3-one (5alpha-dihydrotestosterone) and 5alpha-androstane-3alpha, 17 beta-diol in rat kidney: heterogeneity of 3alpha-hydroxysteroid oxidoreductases. | 3alpha-Hydroxysteroid oxidoreductases catalyzing the interconversion between 17 beta-hydroxy-5alpha-androstan-3-one (5alpha-dihydrotestosterone) and 5alpha-androstane-3alpha, 17 beta-diol (3alpha-androstanediol) have been studied in rat kidney. Three enzymes can be distinguished: a soluble NADPH-dependent oxidoreductas... | Interconversion between 17 beta-hydroxy-5alpha-androstan-3-one (5alpha-dihydrotestosterone) and 5alpha-androstane-3alpha, 17 beta-diol in rat kidney: heterogeneity of 3alpha-hydroxysteroid oxidoreductases. 3alpha-Hydroxysteroid oxidoreductases catalyzing the interconversion between 17 beta-hydroxy-5alpha-androstan-3-on... | [
-0.020176364108920097,
-0.01812731847167015,
-0.020504025742411613,
0.00013633971684612334,
0.022391170263290405,
-0.016776343807578087,
0.011532401666045189,
-0.009002047590911388,
-0.007711618673056364,
-0.0694006085395813,
0.0305694118142128,
-0.11923762410879135,
0.019723454490303993,
... |
PMID:7456 | Influence of DNA acidification on DNA premelting and template properties. | Acidification of a T7 DNA sample was found to be partly irreversible as ultraviolet difference spectra measured at various sub-melting temperatures were different from those observed for a 'normal' DNA sample. This implies some subtle conformational change which is not reversed by return to neutral pH. In the same cond... | Influence of DNA acidification on DNA premelting and template properties. Acidification of a T7 DNA sample was found to be partly irreversible as ultraviolet difference spectra measured at various sub-melting temperatures were different from those observed for a 'normal' DNA sample. This implies some subtle conformatio... | [
-0.08045826852321625,
-0.003342144191265106,
-0.02355252206325531,
0.034466665238142014,
0.0351950004696846,
0.019061822444200516,
0.03683844953775406,
-0.01864577829837799,
-0.02500319667160511,
-0.028979800641536713,
0.005652416031807661,
-0.043825410306453705,
-0.015964053571224213,
-0.... |
PMID:7457 | Reconstitution of chemically synthesized ribooligonucleotides with naturally occurring tRNA fragments. | Chemically synthesized yeast tRNA terminal fragments were reconstituted with natural tRNA fragments which were obtained by partial digestion with RNase T1. The synthetic 3'-nonanucleotide (I) accepted alanine (3% with respect to the intact tRNA) when combined with a 4-fold excess of the natural 5'-quarter and the chemi... | Reconstitution of chemically synthesized ribooligonucleotides with naturally occurring tRNA fragments. Chemically synthesized yeast tRNA terminal fragments were reconstituted with natural tRNA fragments which were obtained by partial digestion with RNase T1. The synthetic 3'-nonanucleotide (I) accepted alanine (3% with... | [
-0.06537839770317078,
-0.009401696734130383,
-0.01734488271176815,
0.01159374974668026,
-0.04075942188501358,
0.014063901267945766,
0.015818506479263306,
0.031990896910429,
-0.0272507406771183,
0.006228176411241293,
-0.0040566520765423775,
-0.06491073966026306,
-0.0006608544499613345,
0.01... |
PMID:7458 | Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L. | An alpha-L-fucosidase had been purified approximately 300-fold from the liver (hepatopancreas) of the marine mollusc Chamelea gallina L. (= Venus gallina L.). During the different steps of the purification procedure it was difficult to remove the contaminant N-acetylglucosaminidase activity; but, after electrofocusing,... | Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L. An alpha-L-fucosidase had been purified approximately 300-fold from the liver (hepatopancreas) of the marine mollusc Chamelea gallina L. (= Venus gallina L.). During the different steps of the purification procedure it ... | [
-0.03219494968652725,
-0.07416867464780807,
-0.06191713735461235,
0.0005609459476545453,
0.02698352560400963,
-0.0949963703751564,
0.03507234901189804,
0.04965725168585777,
-0.030761828646063805,
-0.06585599482059479,
0.013166272081434727,
-0.12192301452159882,
-0.09050559997558594,
0.0428... |
PMID:7459 | Cerebral blood flow, cerebral metabolism and cerebrospinal fluid biochemistry in brain-injured patients after exposure to hyperbaric oxygen. | A series of head-injured patients, in coma, were treated with hyperbaric oxygen (OHP) at 2.5 atm. Cerebral blood flow (CBF), cerebral metabolic rates of oxygen (CMRO2), glucose (CMRGL), and lactate (CMRL act), and various cerebrospinal fluid (CSF) parameters were measured before and 2 h after the treatment. Pre-OHP and... | Cerebral blood flow, cerebral metabolism and cerebrospinal fluid biochemistry in brain-injured patients after exposure to hyperbaric oxygen. A series of head-injured patients, in coma, were treated with hyperbaric oxygen (OHP) at 2.5 atm. Cerebral blood flow (CBF), cerebral metabolic rates of oxygen (CMRO2), glucose (C... | [
-0.048923347145318985,
0.021423952654004097,
-0.022129476070404053,
0.01167344767600298,
-0.019846098497509956,
0.04111107438802719,
0.04264766722917557,
0.017937466502189636,
-0.03151604160666466,
-0.0265339445322752,
0.012342596426606178,
-0.05761408805847168,
-0.010562234558165073,
0.01... |
PMID:7460 | A new type of fluorocarbon liquid oxygenator. | A new oxygenator based on gas transfer across liquid-liquid interfaces (liquid oxygenator) is introduced. Perfluorinated chemicals are used as gas carriers. This liquid oxygenator differs from others in its concept basing on the dispersion of the blood droplets in an inert liquid by means of shear forces. This method a... | A new type of fluorocarbon liquid oxygenator. A new oxygenator based on gas transfer across liquid-liquid interfaces (liquid oxygenator) is introduced. Perfluorinated chemicals are used as gas carriers. This liquid oxygenator differs from others in its concept basing on the dispersion of the blood droplets in an inert ... | [
-0.04038473963737488,
-0.01046043261885643,
0.0010393057018518448,
0.05509437248110771,
-0.0003556242445483804,
-0.004572365898638964,
0.055878739804029465,
0.048343297094106674,
-0.03471410647034645,
-0.01699031889438629,
-0.02468871884047985,
-0.06876242160797119,
-0.055474814027547836,
... |
PMID:7461 | A simplified bloodless procedure for extensive hepatectomy. Experimental study in the pig. | An original procedure of extensive bloodless hepatectomy is described in the pig. Complete vascular liver isolation with aorta clamping up to 25 min allows 60-75% bloodless hepatectomy without any portal triad dissection. Perfect hemostasis and shortening of liver ischemia is obtained with the use of a gelatin-resorcin... | A simplified bloodless procedure for extensive hepatectomy. Experimental study in the pig. An original procedure of extensive bloodless hepatectomy is described in the pig. Complete vascular liver isolation with aorta clamping up to 25 min allows 60-75% bloodless hepatectomy without any portal triad dissection. Perfect... | [
0.02387053519487381,
0.02241605706512928,
0.01904558204114437,
0.019788900390267372,
-0.005402302369475365,
-0.05066124349832535,
-0.01925421506166458,
0.0633012130856514,
-0.05088474228978157,
0.04751284047961235,
0.037612587213516235,
-0.02011238783597946,
-0.04623985290527344,
0.0348110... |
PMID:7466 | Purification and some properties of NADP+ -specific isocitrate dehydrogenase from an extreme thermophile, Thermus flavus AT-62. | Thermostable NADP+ -specific isocitrate dehydrogenase (EC 1.1.1.42) was purified from crude extract of an extremely thermophilic bacterium Thermus flavus AT-62 through DEAE-cellulose column, acetone fractionation, DEAE-Sephadex A-50 column and isoelectric focussing. The enzyme was purified about 500-folds in its specif... | Purification and some properties of NADP+ -specific isocitrate dehydrogenase from an extreme thermophile, Thermus flavus AT-62. Thermostable NADP+ -specific isocitrate dehydrogenase (EC 1.1.1.42) was purified from crude extract of an extremely thermophilic bacterium Thermus flavus AT-62 through DEAE-cellulose column, a... | [
-0.07415200024843216,
0.0214424766600132,
-0.011908999644219875,
0.018190613016486168,
0.07361091673374176,
-0.01568622514605522,
0.04254709929227829,
0.048521194607019424,
-0.07655143737792969,
-0.03841950371861458,
0.03196878358721733,
-0.05291689559817314,
0.03128884360194206,
0.0347410... |
PMID:7467 | Maintainance of specificity, information, and thermostability in thermophilic Bacillus sp. glutamine synthetase. | Glutamine synthetase has been purified to homogeneity from B. subtilis (37 degrees) B. stearothermophilus (55 degrees), and B. caldolyticus (75 degrees). Those characteristics compared include size (6.0 +/- 0.3 X 10(5) daltons), quaternary structure (12 SU) amino acid content, substrate Km's and specificity for structu... | Maintainance of specificity, information, and thermostability in thermophilic Bacillus sp. glutamine synthetase. Glutamine synthetase has been purified to homogeneity from B. subtilis (37 degrees) B. stearothermophilus (55 degrees), and B. caldolyticus (75 degrees). Those characteristics compared include size (6.0 +/- ... | [
-0.040102627128362656,
-0.013122417964041233,
-0.011805727146565914,
0.004509790800511837,
0.025467531755566597,
-0.007797124795615673,
0.07087915390729904,
0.0023036261554807425,
-0.04440637677907944,
-0.037115853279829025,
0.036392778158187866,
-0.08989877253770828,
0.04458991438150406,
... |
PMID:7468 | Properties of enzymes from Clostridium thermoaceticum and Clostridium formicoaceticum. | Methylenetetrahydrofolate dehydrogenase from C. thermoaceticum and C. formicoaceticum have been purified to homogeneity and compared. The two enzymes are very similar physically, chemically, and kinetically, but he C. thermoaceticum enzyme has a higher thermostablility, which is an intrinsic property of the protein. Fo... | Properties of enzymes from Clostridium thermoaceticum and Clostridium formicoaceticum. Methylenetetrahydrofolate dehydrogenase from C. thermoaceticum and C. formicoaceticum have been purified to homogeneity and compared. The two enzymes are very similar physically, chemically, and kinetically, but he C. thermoaceticum ... | [
-0.056279752403497696,
0.036550797522068024,
-0.015133404172956944,
0.06196044012904167,
0.03472214937210083,
-0.0631866604089737,
0.03661072999238968,
0.03281836584210396,
-0.05971634015440941,
-0.043996624648571014,
-0.02938918024301529,
-0.08176621049642563,
0.022960597649216652,
-0.068... |
PMID:7470 | Studies on the inhibition of thermolysin. | Thei nhibition of the thermolysin catalyzed hydrolysis of FA-Gly-Leu-NH2 and FA-Gly-Phe-NH2 has been reported. The results suggest a model for substrate and inhibitor binding involving the hydrophobic specificity pocket, Arg-203 and Glu-143. | Studies on the inhibition of thermolysin. Thei nhibition of the thermolysin catalyzed hydrolysis of FA-Gly-Leu-NH2 and FA-Gly-Phe-NH2 has been reported. The results suggest a model for substrate and inhibitor binding involving the hydrophobic specificity pocket, Arg-203 and Glu-143. | [
-0.06360124796628952,
0.007893321104347706,
-0.012288174591958523,
0.01357275526970625,
0.022107839584350586,
-0.025787772610783577,
0.045896224677562714,
0.015987329185009003,
-0.03941719979047775,
-0.03424030914902687,
-0.00891677662730217,
-0.03883643075823784,
0.03336521238088608,
0.04... |
PMID:7472 | Muscle metabolism investigated at rest and during exercise and/or pharmacological treatment by vasodilators. | The Ruderman's preparation was utilized to investigate in situ some aspects of the muscular metabolism both at rest and during submaximal exercise upon bilateral sciatic nerve stimulation, and/or during perfusion with some vasodilators: papaverine, caffeine, nicergoline, bamethan. O2 and glucose uptake, the production ... | Muscle metabolism investigated at rest and during exercise and/or pharmacological treatment by vasodilators. The Ruderman's preparation was utilized to investigate in situ some aspects of the muscular metabolism both at rest and during submaximal exercise upon bilateral sciatic nerve stimulation, and/or during perfusio... | [
-0.016378898173570633,
-0.016008585691452026,
0.006695127580314875,
0.007408382836729288,
0.03998756408691406,
-0.003310488536953926,
0.006664251908659935,
-0.023033423349261284,
-0.03745858371257782,
-0.03802759200334549,
0.01693996973335743,
-0.020100878551602364,
-0.013438940048217773,
... |
PMID:7473 | Factors in the evolution of hemoglobin function. | The packaging of vertebrate blood hemoglobins within cells places subtle constraints on hemoglobin evolution. Since the concentration of hemoglobin is near the solubility limit a selective advantage should exist for a noncomplementary external topology of amino acid residues. Further, any change in charge on the protei... | Factors in the evolution of hemoglobin function. The packaging of vertebrate blood hemoglobins within cells places subtle constraints on hemoglobin evolution. Since the concentration of hemoglobin is near the solubility limit a selective advantage should exist for a noncomplementary external topology of amino acid resi... | [
-0.08964314311742783,
0.022273406386375427,
-0.022742904722690582,
0.03660397604107857,
-0.01015162281692028,
-0.027671564370393753,
0.08610169589519501,
0.013559776358306408,
-0.021850841119885445,
0.013734216801822186,
0.017690973356366158,
-0.10708168894052505,
-0.016050567850470543,
-0... |
PMID:7476 | Testicular microlithiasis with sterility. | A case report of male infertility associated with testicular microlithiasis is presented. This rare condition has not previously been associated with infertility. A variable maturation arrest was observed in the spermatogenic epithelium. The question of whether the microliths are the cause of the infertility or whether... | Testicular microlithiasis with sterility. A case report of male infertility associated with testicular microlithiasis is presented. This rare condition has not previously been associated with infertility. A variable maturation arrest was observed in the spermatogenic epithelium. The question of whether the microliths a... | [
0.051081497222185135,
0.02288852632045746,
0.007124194409698248,
0.002140308730304241,
-0.05747748538851738,
-0.009634396992623806,
0.016566788777709007,
0.05063308775424957,
-0.0002075683296425268,
-0.006382941734045744,
-0.0337969996035099,
-0.08813180774450302,
0.03276795148849487,
0.00... |
PMID:7477 | Quantitative parameters for light microscopic assessment of the tubuli seminiferi. | For quantitative, histologic assessment of the testis tubuli there are four suitable parameters: diameter of tubulus, area of tubulus, number of cell nuclei per tubulus, and area of nuclei of the various cells participating in spermatogenesis. For estimating areas, the integrative method of measurement, either with a g... | Quantitative parameters for light microscopic assessment of the tubuli seminiferi. For quantitative, histologic assessment of the testis tubuli there are four suitable parameters: diameter of tubulus, area of tubulus, number of cell nuclei per tubulus, and area of nuclei of the various cells participating in spermatoge... | [
0.0440603569149971,
-0.04048601910471916,
0.04222423955798149,
-0.0016246753511950374,
-0.01889566332101822,
0.06444255262613297,
0.07150787860155106,
0.05803052335977554,
-0.006063767708837986,
0.019020475447177887,
0.007518220227211714,
-0.13419993221759796,
0.031541600823402405,
0.03470... |
PMID:7482 | Influence of a meal on the absorption of cimetidine. A new histamine H2-receptor antagonist. | Absorption of an oral dose of 300 mg of Cimetidine was studied after an overnight fast in six healthy male volunteers on three separate occasions, 20 min before, during, and 2 h after a standard breakfast. Compared to the doses taken before and after the meal, the dose taken with the meal showed a significant delay in ... | Influence of a meal on the absorption of cimetidine. A new histamine H2-receptor antagonist. Absorption of an oral dose of 300 mg of Cimetidine was studied after an overnight fast in six healthy male volunteers on three separate occasions, 20 min before, during, and 2 h after a standard breakfast. Compared to the doses... | [
-0.022412391379475594,
-0.005391910672187805,
-0.02920851670205593,
0.0396423265337944,
-0.013620995916426182,
-0.009236346930265427,
0.06190074607729912,
0.027175212278962135,
-0.0207175575196743,
-0.05669409781694412,
0.02537727542221546,
-0.026142889633774757,
0.018377181142568588,
0.01... |
PMID:7517 | Hemoglobin function in stored blood. XIII. A citrate-adenine preservative with optimal pH to maintain red cell 2,3-DPG (function) and ATP (viability). | Increasing pH by a 0.5 increment over the commonly used preservative, acid-citrate-dextrose with adenine (ACD-Ad), results in a significant improvement in 2,3-DPG, with no significant loss in concentrations of ATP. The intermediate pH preservative, 6.0, also had ATP concentrations which equaled those of the low pH pres... | Hemoglobin function in stored blood. XIII. A citrate-adenine preservative with optimal pH to maintain red cell 2,3-DPG (function) and ATP (viability). Increasing pH by a 0.5 increment over the commonly used preservative, acid-citrate-dextrose with adenine (ACD-Ad), results in a significant improvement in 2,3-DPG, with ... | [
-0.1160009503364563,
0.027338875457644463,
0.004511082544922829,
0.014599848538637161,
0.01042831689119339,
-0.0021912623196840286,
0.09709390997886658,
0.015329550951719284,
-0.0503963865339756,
0.007291373796761036,
0.03116300329566002,
-0.07752368599176407,
-0.003412438789382577,
0.0122... |
PMID:7519 | [Studies on biosynthesis of short-chain fatty acids (author's transl)]. | Studies were reported here on biosynthesis of short-chain fatty acids in lactating rabbit mammary glands. The maximal incorporation from [1-14C] acetate into total fatty acids were observed in microsomes and supernatant fractions of mammary glands but the synthetic rate either in the microsomes alone or in the supernat... | [Studies on biosynthesis of short-chain fatty acids (author's transl)]. Studies were reported here on biosynthesis of short-chain fatty acids in lactating rabbit mammary glands. The maximal incorporation from [1-14C] acetate into total fatty acids were observed in microsomes and supernatant fractions of mammary glands ... | [
-0.032576125115156174,
-0.01931329444050789,
-0.0008010542951524258,
0.027003679424524307,
-0.005893286317586899,
0.013111528009176254,
-0.0273303035646677,
0.01679079234600067,
-0.0483529306948185,
-0.040546517819166183,
0.08095566183328629,
-0.10693611949682236,
0.06588896363973618,
-0.0... |
PMID:7520 | An analysis of the relationships among obesity, plasma insulin and hepatic lipogenic enzymes in "viable yellow obese" mice (Avy/a). | The development of obesity, hyperinsulinemia and six hepatic lipogenic enzymes in Avy/a mice were compared to that in a/a mice. Correlation between body weight, liver weight, plasma insulin concentration and activities of hepatic enzymes was analyzed. In the Avy/a mice, body weight, liver weight and plasma insulin leve... | An analysis of the relationships among obesity, plasma insulin and hepatic lipogenic enzymes in "viable yellow obese" mice (Avy/a). The development of obesity, hyperinsulinemia and six hepatic lipogenic enzymes in Avy/a mice were compared to that in a/a mice. Correlation between body weight, liver weight, plasma insuli... | [
-0.03865422308444977,
-0.035735007375478745,
0.05327938124537468,
0.0498921275138855,
0.010846712626516819,
-0.0012024948373436928,
0.04569976404309273,
0.07438620179891586,
-0.06902798265218735,
-0.012680958025157452,
0.027356332167983055,
-0.1052541732788086,
-0.027378497645258904,
0.024... |
PMID:7532 | Studies on normal human bone marrow cultures in controlled environment thin-film culture systems. | Two thin film culture systems, the controlled environment steady state system (SS) and the rocker tube configuration of that system (RT), were used to identify some of the conditions that appear to maintain morphologic and functional characteristics of cells of human bone marrow explants in vitro. The systems configura... | Studies on normal human bone marrow cultures in controlled environment thin-film culture systems. Two thin film culture systems, the controlled environment steady state system (SS) and the rocker tube configuration of that system (RT), were used to identify some of the conditions that appear to maintain morphologic and... | [
-0.02524307556450367,
0.06248226389288902,
0.03281337395310402,
-0.00047309562796726823,
0.010318636894226074,
0.019338112324476242,
-0.004491065628826618,
0.050592776387929916,
-0.05341574549674988,
0.03303145617246628,
-0.014457781799137592,
-0.03458975628018379,
0.0017725330544635653,
0... |
PMID:7533 | Bactericidal mechanisms in rabbit alveolar macrophages: evidence against peroxidase and hydrogen peroxide bactericidal mechanisms. | The role of peroxidase-mediated bacterial killing by rabbit alveolar macrophages was examined. During 3 h of incubation in vitro, alveolar macrophages ingested and killed greater than 88% of the Streptococcus faecalis, Proteus mirabilis, or Streptococcus pneumoniae present in the incubation mixture. Preincubation of al... | Bactericidal mechanisms in rabbit alveolar macrophages: evidence against peroxidase and hydrogen peroxide bactericidal mechanisms. The role of peroxidase-mediated bacterial killing by rabbit alveolar macrophages was examined. During 3 h of incubation in vitro, alveolar macrophages ingested and killed greater than 88% o... | [
-0.041798051446676254,
-0.024775829166173935,
-0.019271885976195335,
-0.018421342596411705,
0.04363926872611046,
-0.04048055037856102,
0.049845270812511444,
0.08613704890012741,
-0.059346191585063934,
0.01568767800927162,
-0.010135462507605553,
-0.06238190457224846,
0.022017352283000946,
0... |
PMID:7534 | Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin. | Carbenicillin or ticarcillin were incubated individually with each of the following antibiotics: gentamicin, tobramycin, sisomicin, amikacin. The residual activity of each aminoglycoside in this mixture was assayed enzymatically. Amikacin was inactivated the least of the aminoglycosides. Both penicillins inactivated ea... | Interactions between aminoglycoside antibiotics and carbenicillin or ticarillin. Carbenicillin or ticarcillin were incubated individually with each of the following antibiotics: gentamicin, tobramycin, sisomicin, amikacin. The residual activity of each aminoglycoside in this mixture was assayed enzymatically. Amikacin ... | [
-0.025000952184200287,
-0.026957664638757706,
0.004171071108430624,
-0.018875977024435997,
0.03193651884794235,
-0.06527864187955856,
-0.011830059811472893,
0.060563478618860245,
-0.06207668036222458,
-0.062087662518024445,
0.021946975961327553,
-0.0336301252245903,
0.042178284376859665,
0... |
PMID:7535 | Effects of beta-adrenergic stimulation on bone-marrow function in normal and sublethally irradiated mice. I. The effect of isoproterenol on cAMP content in bone-marrow cells in vivo and in vitro. | The effect of isoproterenol (IPR) on bone-marrow cAMP content was investigated in vivo and in vitro. In unirradiated CFW mice, the bone-marrow cAMP content was found to be elevated by the administration of noradrenaline, adrenaline and isoproterenol. After IPR administration, the increase in cAMP was biphasic with maxi... | Effects of beta-adrenergic stimulation on bone-marrow function in normal and sublethally irradiated mice. I. The effect of isoproterenol on cAMP content in bone-marrow cells in vivo and in vitro. The effect of isoproterenol (IPR) on bone-marrow cAMP content was investigated in vivo and in vitro. In unirradiated CFW mic... | [
-0.051947273313999176,
0.006907786708325148,
-0.019343890249729156,
0.0066966162994503975,
0.006895431317389011,
0.031223507598042488,
0.003075024811550975,
0.04258040711283684,
-0.059767331928014755,
-0.055142030119895935,
0.04805273190140724,
-0.003291632514446974,
-0.0024146141950041056,
... |
PMID:7537 | Lorazepam and diazepam in anxious outpatients. A controlled study. | The response of 134 anxious neurotic outpatients to lorazepam, diazepam, and placebo was assessed in a 4-week double-blind trial. Both active drugs produced significantly more symptom reduction than placebo. Lorazepam, however, proved effective primarily in those patients who did not complain of sedation, and produced ... | Lorazepam and diazepam in anxious outpatients. A controlled study. The response of 134 anxious neurotic outpatients to lorazepam, diazepam, and placebo was assessed in a 4-week double-blind trial. Both active drugs produced significantly more symptom reduction than placebo. Lorazepam, however, proved effective primaril... | [
0.0040976800955832005,
0.01781604252755642,
0.026035072281956673,
0.05462389066815376,
0.004436757881194353,
-0.004131740890443325,
0.06097499653697014,
0.04489698261022568,
-0.022931568324565887,
-0.06267797201871872,
-0.011136421002447605,
0.04690681770443916,
-0.01666480302810669,
0.025... |
PMID:7542 | Collaborative study of a spectrofluorometric assay for Rauwolfia serpentina tablets and powdered root. | Reserpine-rescinnamine group alkaloids are extracted from Rauwolfia serpentina preparations into a dimethylsulfoxide (DMSO)-methanol mixture and diluted with 0.5N H2SO4. The chloroform extract of this solution is passed through a 0.1N NaOH-Celite column and then through a silica gel column. The weakly basic alkaloids t... | Collaborative study of a spectrofluorometric assay for Rauwolfia serpentina tablets and powdered root. Reserpine-rescinnamine group alkaloids are extracted from Rauwolfia serpentina preparations into a dimethylsulfoxide (DMSO)-methanol mixture and diluted with 0.5N H2SO4. The chloroform extract of this solution is pass... | [
-0.04796595871448517,
0.017726195976138115,
-0.021086975932121277,
0.027003875002264977,
0.0332459956407547,
-0.04288510978221893,
-0.033460140228271484,
0.026132162660360336,
-0.1182670146226883,
-0.05055038258433342,
-0.011279361322522163,
-0.052763067185878754,
0.01137152872979641,
0.01... |
PMID:7543 | Iron uptake in colicin B-resistant mutants of Escherichia coli K-12. | Four classes of colicin B-resistant mutants of Escherichia coli K-12 were examined for defects in iron uptake. All four mutant classes (cbt, exbC, exbB, and tonB) were defective in the uptake of ferri-ennterochelin. The tonB mutant was also defective in citrate-, ferrichrome-, and rhodoturulic acid-mediated iron uptake... | Iron uptake in colicin B-resistant mutants of Escherichia coli K-12. Four classes of colicin B-resistant mutants of Escherichia coli K-12 were examined for defects in iron uptake. All four mutant classes (cbt, exbC, exbB, and tonB) were defective in the uptake of ferri-ennterochelin. The tonB mutant was also defective ... | [
-0.08560541272163391,
-0.03424103930592537,
-0.01684485375881195,
0.012611981481313705,
0.009612870402634144,
-0.05745810642838478,
0.015929657965898514,
0.03127723187208176,
-0.08626089245080948,
-0.02558152563869953,
0.012500794604420662,
-0.11713658273220062,
0.02170220948755741,
-0.007... |
PMID:7544 | Calcium-requiring step in the uptake of deoxyribonucleic acid molecules through the surface of competent pneumococci. | The conversion of surface-adsorbed deoxyribonucleic acid (DNA) molecules to a state in which they are inaccessible to exogenous deoxyribonuclease requires specifically calcium ions; magnesium ions cannot replace calcium ions. Virtually maximal levels of nuclease-resistant DNA binding and genetic transformation can be o... | Calcium-requiring step in the uptake of deoxyribonucleic acid molecules through the surface of competent pneumococci. The conversion of surface-adsorbed deoxyribonucleic acid (DNA) molecules to a state in which they are inaccessible to exogenous deoxyribonuclease requires specifically calcium ions; magnesium ions canno... | [
-0.01831529662013054,
-0.0031673992052674294,
-0.03530615568161011,
0.011411590501666069,
-0.01376012060791254,
-0.01951621100306511,
0.059420011937618256,
0.05765871703624725,
-0.03901861980557442,
0.017501940950751305,
0.02391187660396099,
-0.10811108350753784,
0.019558599218726158,
-0.0... |
PMID:7545 | Mechanism of autolysis of Neisseria gonorrhoeae. | The major autolysin(s) of Neisseria gonorrhoeae was solubilized from envelopes by extraction with 2% Triton X-100 containing 0.5 M NaCl. Neither Triton X-100 nor NaCl alone could effectively release the autolysin(s). The major autolysin is N-acetylmuramyl-L-alanine amidase (EC 3.5.1.28). The pH optimum for this reactio... | Mechanism of autolysis of Neisseria gonorrhoeae. The major autolysin(s) of Neisseria gonorrhoeae was solubilized from envelopes by extraction with 2% Triton X-100 containing 0.5 M NaCl. Neither Triton X-100 nor NaCl alone could effectively release the autolysin(s). The major autolysin is N-acetylmuramyl-L-alanine amida... | [
-0.044347796589136124,
-0.012687431648373604,
-0.017035961151123047,
-0.007687750738114119,
0.007468144875019789,
-0.06906891614198685,
-0.004175450187176466,
0.03598751872777939,
-0.06964662671089172,
-0.00045070183114148676,
0.026080485433340073,
-0.04787067323923111,
0.011317568831145763,... |
PMID:7546 | Magnitude of the protonmotive force in respiring Staphylococcus aureus and Escherichia coli. | The membrane potential and pH gradient developed across the plasma membranes of whole cells of Staphylococcus aureus and spheroplasts of Escherichia coli were estimated. The distributions of potassium ions in the presence of valinomycin and the pH gradient across the membrane were determined from the changes in pK and ... | Magnitude of the protonmotive force in respiring Staphylococcus aureus and Escherichia coli. The membrane potential and pH gradient developed across the plasma membranes of whole cells of Staphylococcus aureus and spheroplasts of Escherichia coli were estimated. The distributions of potassium ions in the presence of va... | [
-0.1141822412610054,
-0.02892557717859745,
-0.005838112439960241,
0.03695901483297348,
0.03307022899389267,
-0.043477024883031845,
0.010434473864734173,
0.037546202540397644,
-0.016752352938055992,
0.037182435393333435,
0.036758918315172195,
-0.05938969552516937,
-0.008501190692186356,
0.0... |
PMID:7547 | Proton movements coupled to lactate and alanine transport in Escherichia coli: isolation of mutants with altered stoichiometry in alanine transport. | The addition of lactate to lightly buffered suspensions of resting cells of Escherichia coli caused an increase in the pH of the extracellular phase as lactate and protons entered the cell together. From the magnitude of the pH change and the non-electrogenic character of lactate uptake, we concluded that the stoichiom... | Proton movements coupled to lactate and alanine transport in Escherichia coli: isolation of mutants with altered stoichiometry in alanine transport. The addition of lactate to lightly buffered suspensions of resting cells of Escherichia coli caused an increase in the pH of the extracellular phase as lactate and protons... | [
-0.08704432100057602,
-0.05325273051857948,
-0.04156893864274025,
0.029081759974360466,
0.01672254130244255,
-0.044018279761075974,
0.009520803578197956,
-0.021243778988718987,
0.005008381325751543,
0.011256711557507515,
0.03732752427458763,
-0.08526872843503952,
0.016884779557585716,
0.04... |
PMID:7548 | Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli. | The enzyme L-threonine dehydrogenase was demonstrated in extracts of Escherichia coli K-12, and was shown to be the first enzyme of the pathway converting threonine to glycine. The enzyme was induced by L-leucine, but not by its substrate, L-threonine. The metabolic significance of leucine as a catabolic signal for ami... | Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli. The enzyme L-threonine dehydrogenase was demonstrated in extracts of Escherichia coli K-12, and was shown to be the first enzyme of the pathway converting threonine to glycine. The enzyme was induced by L-leuc... | [
-0.08615536987781525,
0.003992174752056599,
-0.0768328309059143,
0.04506879672408104,
0.025614585727453232,
-0.053606003522872925,
-0.005388425663113594,
0.03216232359409332,
-0.00294618122279644,
0.0033914779778569937,
0.030765486881136894,
-0.07378344237804413,
0.032440826296806335,
0.00... |
PMID:7549 | Partial characterization of a temperature-sensitive mutation affecting acetyl coenzyme A carboxylase in Escherichia coli K-12. | A temperature-sensitive mutation in Escherichia coli K-12 was shown to affect acetyl coenzyme A carboxylase and to map at min 63. This site is designated fabE. | Partial characterization of a temperature-sensitive mutation affecting acetyl coenzyme A carboxylase in Escherichia coli K-12. A temperature-sensitive mutation in Escherichia coli K-12 was shown to affect acetyl coenzyme A carboxylase and to map at min 63. This site is designated fabE. | [
-0.07838668674230576,
-0.0053672692738473415,
-0.01945997215807438,
0.060157906264066696,
0.06324660032987595,
-0.027240341529250145,
0.027709711343050003,
0.02331795170903206,
-0.07723912596702576,
-0.05050453916192055,
0.055625591427087784,
-0.0795632153749466,
0.0316670797765255,
0.0374... |
PMID:7550 | Potentiometric studies on benzeneboronic acid-alpha-chymotrypsin interactions. | When the competitive inhibitor benzeneboronic acid (BBA) forms a complex with alpha-chymotrypsin [EC 3.4.21.1] protons are released in the acidic pH region. The proton release can be measured by a difference potentiometric technique. The proton release is also observed in chymotrypsinogen A but not in TRCK-, DIP-, and ... | Potentiometric studies on benzeneboronic acid-alpha-chymotrypsin interactions. When the competitive inhibitor benzeneboronic acid (BBA) forms a complex with alpha-chymotrypsin [EC 3.4.21.1] protons are released in the acidic pH region. The proton release can be measured by a difference potentiometric technique. The pro... | [
-0.09414403140544891,
-0.021012675017118454,
-0.07978852093219757,
0.006205686833709478,
-0.004256956744939089,
-0.04136113077402115,
0.05387823283672333,
0.013888005167245865,
-0.013962006196379662,
-0.053119707852602005,
0.015480725094676018,
-0.0765392929315567,
-0.003074443666264415,
0... |
PMID:7551 | The removal of non-collagen components from newborn calf dermis with magnesium chloride solution. | 1. Non-collagenous substances in newborn calf dermis were extracted with solutions of various concentrations of MgCl2. The total protein and hydroxyproline contents in MgCl2 extracts increased with increase in the concentration of MgCl2 in the solutions. In particular, steep increases of their contents were observed at... | The removal of non-collagen components from newborn calf dermis with magnesium chloride solution. 1. Non-collagenous substances in newborn calf dermis were extracted with solutions of various concentrations of MgCl2. The total protein and hydroxyproline contents in MgCl2 extracts increased with increase in the concentr... | [
-0.06972958147525787,
-0.029442250728607178,
0.01850891299545765,
0.01221612561494112,
0.05841444060206413,
-0.01823289692401886,
0.01822824403643608,
0.06480623781681061,
-0.09368879348039627,
-0.009243648499250412,
0.008045916445553303,
-0.12178607285022736,
0.0315401591360569,
-0.007381... |
PMID:7552 | Altered prephenate dehydratase in phenylalanine-excreting mutants of Brevibacterium flavum. | The regulatory properties of three key enzymes in the phenylalanine biosynthetic pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase (DAHP synthetase) [EC 4.1.2.15], chorismate mutase [EC 5.4.99.5], and prephenate dehydratase [prephenate hydro-lyase (decarboxylating), EC 4.2.1.51] were compared in three phe... | Altered prephenate dehydratase in phenylalanine-excreting mutants of Brevibacterium flavum. The regulatory properties of three key enzymes in the phenylalanine biosynthetic pathway, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase (DAHP synthetase) [EC 4.1.2.15], chorismate mutase [EC 5.4.99.5], and prephenate de... | [
-0.07868905365467072,
-0.02707703784108162,
-0.047419022768735886,
0.007491518277674913,
0.028931835666298866,
-0.047226808965206146,
-0.01534949243068695,
0.005058312322944403,
-0.02571517787873745,
-0.01680648699402809,
0.029439806938171387,
-0.10996630787849426,
0.03454968333244324,
0.0... |
PMID:7553 | Two glycosulfatases from the liver of a marine gastropod, Charonia lampas. Partial purification and properties. | Two glycosulfatases [EC 3.1.6.3], I and II, were purified 31.3- and 33.9-fold respectively, from a crude extract of the liver of Charonia lampas. The purification was carried out by the following chromatographic procedures; phosphocellulose, Sephadex G-150, Concanavalin A-Sepharose and isoelectric focussing. The enzyme... | Two glycosulfatases from the liver of a marine gastropod, Charonia lampas. Partial purification and properties. Two glycosulfatases [EC 3.1.6.3], I and II, were purified 31.3- and 33.9-fold respectively, from a crude extract of the liver of Charonia lampas. The purification was carried out by the following chromatograp... | [
-0.033373963087797165,
-0.03335857018828392,
-0.04826686158776283,
-0.046377234160900116,
-0.0032624383457005024,
-0.05823366343975067,
0.020647261291742325,
0.0348091758787632,
-0.0542474165558815,
-0.015829700976610184,
0.02231833152472973,
-0.08857516944408417,
-0.0502922423183918,
0.02... |
PMID:7554 | Comparative studies on polyguanylate polymerase and polyadenylate polymerase activities in the DNA-dependent RNA polymerase I fraction from cauliflower. | The properties of poly(G) polymerase and poly(A) polymerase activities in the DNA-dependent RNA polymerase [nucleosidetriphosphate: RNA nucleotidyltransferase EC 2.7.7.6] I fraction from cauliflower (Brassica oleracea var. botrytis) were comparatively investigated. The pH optimum, the effect of ionic strength, the effe... | Comparative studies on polyguanylate polymerase and polyadenylate polymerase activities in the DNA-dependent RNA polymerase I fraction from cauliflower. The properties of poly(G) polymerase and poly(A) polymerase activities in the DNA-dependent RNA polymerase [nucleosidetriphosphate: RNA nucleotidyltransferase EC 2.7.7... | [
-0.026170717552304268,
-0.02380646951496601,
0.021667461842298508,
-0.013768177479505539,
0.05059443414211273,
0.03793957084417343,
-0.008998199366033077,
0.03854462504386902,
-0.022839250043034554,
0.025626305490732193,
0.005133608356118202,
-0.025456339120864868,
0.001583874924108386,
-0... |
PMID:7555 | Studies on the molecular species of DNA polymerase extracted from rat ascites hepatoma cells. | DNA polymerase [EC 2.7.7.7] activities present in hypotonic extract from rat ascites hepatoma AH130 cells were eluted in three separable peaks on DEAE-cellulose column chromatography. Peak I activity had an alkaline pH optimum, and was relatively resistant to SH-blocking reagents and salt concentration. These propertie... | Studies on the molecular species of DNA polymerase extracted from rat ascites hepatoma cells. DNA polymerase [EC 2.7.7.7] activities present in hypotonic extract from rat ascites hepatoma AH130 cells were eluted in three separable peaks on DEAE-cellulose column chromatography. Peak I activity had an alkaline pH optimum... | [
-0.10138756036758423,
0.026085086166858673,
0.006104188971221447,
0.005975002888590097,
-0.016653908416628838,
0.03047909028828144,
0.050437815487384796,
0.06084710732102394,
-0.027338631451129913,
-0.007857423275709152,
0.04437781125307083,
-0.016086295247077942,
-0.04793776944279671,
0.0... |
PMID:7556 | Formation of interchain disulfide bonds in Bence Jones proteins and immunoglobulins. | The formation of the interchain disulfide bonds in partially reduced Bence Jones proteins and immunoglobulins was studied in the presence of glutathione. It was found that only oxidized glutathione (GSSG) was effective for the formation of the interchain disulfide bonds in type gamma Bence Jones proteins and IgG. In ty... | Formation of interchain disulfide bonds in Bence Jones proteins and immunoglobulins. The formation of the interchain disulfide bonds in partially reduced Bence Jones proteins and immunoglobulins was studied in the presence of glutathione. It was found that only oxidized glutathione (GSSG) was effective for the formatio... | [
-0.06637021154165268,
0.009765679948031902,
-0.050988178700208664,
-0.037414126098155975,
-0.009757139720022678,
-0.01656828634440899,
0.021795086562633514,
-0.0006645534886047244,
-0.036570195108652115,
-0.020909719169139862,
0.007228949572890997,
-0.04118676111102104,
0.037647295743227005,... |
PMID:7557 | Studies on alpha-amylase from a thermophilic bacterium. II. Thermal stability of the thermophilic alpha-amylase. | The effect of pH, mental ions, and denaturing reagents on the thermal stability of thermophilic alpha-amylase [EC 3.2.1.1] were examined. The enzyme was most stable at around pH 9.2, which is coincident with the isoelectric point of the enzyme. The stability of the enzyme was increased by the addition of calcium, stron... | Studies on alpha-amylase from a thermophilic bacterium. II. Thermal stability of the thermophilic alpha-amylase. The effect of pH, mental ions, and denaturing reagents on the thermal stability of thermophilic alpha-amylase [EC 3.2.1.1] were examined. The enzyme was most stable at around pH 9.2, which is coincident with... | [
-0.05848318338394165,
-0.021612955257296562,
-0.0034612587187439203,
0.0004360268358141184,
-0.004057569894939661,
-0.06531379371881485,
0.028134914115071297,
0.028270497918128967,
-0.05165240541100502,
-0.05691029503941536,
0.021335292607545853,
-0.07998648285865784,
0.0069016749039292336,
... |
PMID:7558 | Activation process of pepsinogen. | The activation process of pepsinogen was analyzed by a combination of computer simulation and experiment. In order to investigate in detail the behavior of the basic schemes proposed in the previous study, further computer simulations were conducted. Some experiments were performed based on the information obtained. Th... | Activation process of pepsinogen. The activation process of pepsinogen was analyzed by a combination of computer simulation and experiment. In order to investigate in detail the behavior of the basic schemes proposed in the previous study, further computer simulations were conducted. Some experiments were performed bas... | [
-0.057639021426439285,
-0.01717827282845974,
-0.032091956585645676,
0.01117840688675642,
0.014254882000386715,
0.01414962112903595,
0.07181140035390854,
0.042758598923683167,
-0.02561490796506405,
-0.04783811792731285,
0.026155224069952965,
-0.0512954406440258,
-0.014978993684053421,
0.007... |
PMID:7559 | An oxygraphic method for the determination of cholesterol and measurement of the slow oxygen-consuming reactions of hepatic microsomes. | Oxygen-consuming reactions of cholesterol oxidase [EC 1.1.3.6] and microsomes were measured with a galvanic oxygen electrode which was attached to an offset amplifier for sensitive measurement of the reaction processes. The sensitivity of this oxygraphic method for detection of oxygen consumption was ten times greater ... | An oxygraphic method for the determination of cholesterol and measurement of the slow oxygen-consuming reactions of hepatic microsomes. Oxygen-consuming reactions of cholesterol oxidase [EC 1.1.3.6] and microsomes were measured with a galvanic oxygen electrode which was attached to an offset amplifier for sensitive mea... | [
-0.04298972710967064,
0.054374225437641144,
-0.0280316062271595,
0.020155925303697586,
0.004010208882391453,
-0.007906639948487282,
0.027940217405557632,
0.022947827354073524,
-0.006851342972368002,
-0.036571186035871506,
0.006233554799109697,
-0.06794505566358566,
0.0306593868881464,
0.01... |
PMID:7560 | Purification and properties of cathepsin D from porcine spleen. | Cathepsin D was purified from porcine spleen to near homogeneity as determined by gel electrophoresis. The isolation scheme involved an acid precipitation of tissue extract, DEAE-cellulose and Sephadex G-200 chromatography, and isoelectric focusing. The end product represented about a 1000-fold purification and about a... | Purification and properties of cathepsin D from porcine spleen. Cathepsin D was purified from porcine spleen to near homogeneity as determined by gel electrophoresis. The isolation scheme involved an acid precipitation of tissue extract, DEAE-cellulose and Sephadex G-200 chromatography, and isoelectric focusing. The en... | [
-0.041491784155368805,
-0.011092018336057663,
-0.06658139079809189,
-0.021665047854185104,
-0.00863073579967022,
-0.049522072076797485,
0.09469678997993469,
0.04742279276251793,
-0.014164446853101254,
0.006475319620221853,
0.019440824165940285,
-0.10606132447719574,
0.0071023814380168915,
... |
PMID:7561 | Regulation of the transmembrane potential of isolated chromaffin granules by ATP, ATP analogs, and external pH. | The transmembrane potential of isolated chromaffin granules has been measured using the permeant ions [14C]methylamine and [35S]thiocyanate, as well as the fluorescent probe, 9-aminoacridine. At pH 7.0, the granule membrane had a Nernst proton potential of -45mV, inside negative. This potential was sensitive to the ext... | Regulation of the transmembrane potential of isolated chromaffin granules by ATP, ATP analogs, and external pH. The transmembrane potential of isolated chromaffin granules has been measured using the permeant ions [14C]methylamine and [35S]thiocyanate, as well as the fluorescent probe, 9-aminoacridine. At pH 7.0, the g... | [
-0.05923791229724884,
-0.03317118063569069,
0.02152741327881813,
0.031418148428201675,
-0.013951286673545837,
-0.005046474747359753,
0.06625616550445557,
0.038730066269636154,
-0.026033753529191017,
-0.012448376044631004,
0.007406702730804682,
-0.0593671090900898,
-0.0016629190649837255,
0... |
PMID:7562 | Studies on the subcellular localization and properties of bis(monoacylglyceryl)phosphate biosynthesis in rat liver. | Phosphatidylglycerol conversion to bis(monoacylglyceryl)phosphate by rat liver homogenate was studied and maximum rates of synthesis were observed at pH 4.4. The distribution of bis(monoacylglyceryl)P synthetase in rat liver subcellular fractions was determined, and evidence is presented establishing the lysosomes as t... | Studies on the subcellular localization and properties of bis(monoacylglyceryl)phosphate biosynthesis in rat liver. Phosphatidylglycerol conversion to bis(monoacylglyceryl)phosphate by rat liver homogenate was studied and maximum rates of synthesis were observed at pH 4.4. The distribution of bis(monoacylglyceryl)P syn... | [
-0.06669215112924576,
-0.06974535435438156,
0.010177119635045528,
-0.0325092114508152,
-0.0417412593960762,
-0.05301690101623535,
0.05592229589819908,
0.047662146389484406,
-0.023170512169599533,
-0.005292870569974184,
0.056572217494249344,
-0.09528505057096481,
0.022614821791648865,
0.008... |
PMID:7563 | Properties of the guanylate cyclase-guanosine 3':5'-monophosphate system of rat renal cortex. Activation of guanylate cyclase and calcium-independent modulation of tissue guanosine 3':5'-monophosphate by sodium azide. | The effects of sodium azide on guanylate cyclase activity of homogenates of rat renal cortex and on the guanosine 3':5'-monophosphate (cGMP) content of cortical slices were examined and compared to those of carbamylcholine and NaF. In complete Krebs-Ringer bicarbonate buffer containing 10 mM theophylline, tissue cGMP c... | Properties of the guanylate cyclase-guanosine 3':5'-monophosphate system of rat renal cortex. Activation of guanylate cyclase and calcium-independent modulation of tissue guanosine 3':5'-monophosphate by sodium azide. The effects of sodium azide on guanylate cyclase activity of homogenates of rat renal cortex and on th... | [
-0.05034060403704643,
-0.03914376720786095,
0.004828426521271467,
-0.00021930673392489552,
-0.008092601783573627,
-0.0010705140884965658,
0.053959377110004425,
0.020643392577767372,
-0.009558666497468948,
-0.0015402042772620916,
0.01637914776802063,
-0.0413985513150692,
0.01135898008942604,
... |
PMID:7564 | Requirement of an essential thiol group and ferric iron for the activity of the progesterone-induced porcine uterine purple phosphatase. | The progesterone-induced purple phosphatase isolated from the uterine flushings of pigs is activated by a variety of reagents that cleave disulfide bonds, including 2-mercaptoethanol, dithiothreitol, L-ascorbate, L-cysteine, sulfite, and cyanide. It is inhibited by various mercurials, iodoacetamide, O-iodosobenzoate, a... | Requirement of an essential thiol group and ferric iron for the activity of the progesterone-induced porcine uterine purple phosphatase. The progesterone-induced purple phosphatase isolated from the uterine flushings of pigs is activated by a variety of reagents that cleave disulfide bonds, including 2-mercaptoethanol,... | [
-0.060615286231040955,
0.013535880483686924,
-0.09003474563360214,
0.06887518614530563,
0.007330095861107111,
-0.014494105242192745,
0.06291388720273972,
0.04788193851709366,
-0.05470765754580498,
-0.018727820366621017,
0.023836225271224976,
-0.07903074473142624,
-0.014538826420903206,
0.0... |
PMID:7565 | Distribution of enzyme activities in subcellular fractions of bovine retina. | Centrifugation of homogenates of bovine retinas to isopycnic equilibrium in sucrose density gradients yielded three partially overlapping bands of particles which were, in the order of increasing density: (a) photoreceptor cell (rod) outer segments; (b) plasma membranes, lysosomes, and large fragments of endoplasmic re... | Distribution of enzyme activities in subcellular fractions of bovine retina. Centrifugation of homogenates of bovine retinas to isopycnic equilibrium in sucrose density gradients yielded three partially overlapping bands of particles which were, in the order of increasing density: (a) photoreceptor cell (rod) outer seg... | [
-0.031794533133506775,
-0.07163164764642715,
-0.038445357233285904,
0.010466543026268482,
0.03393494337797165,
-0.029292065650224686,
0.07875014841556549,
0.005764374043792486,
0.023948680609464645,
0.021420441567897797,
0.004594065248966217,
-0.10266771912574768,
-0.03129825368523598,
0.0... |
PMID:7566 | Kinetic studies of sheep kidney gamma-glutamyl transpeptidase. | The kinetics of sheep kidney gamma-glutamyl transpeptidase was studied using a novel substrate L-alpha-methyl-gamma-glutamyl-L-alpha-aminobutyrate. When the substrate was incubated with the enzyme in the presence of an amino acid or peptide acceptor, the corresponding L-alpha-methyl-gamma-glutamyl derivatives of the ac... | Kinetic studies of sheep kidney gamma-glutamyl transpeptidase. The kinetics of sheep kidney gamma-glutamyl transpeptidase was studied using a novel substrate L-alpha-methyl-gamma-glutamyl-L-alpha-aminobutyrate. When the substrate was incubated with the enzyme in the presence of an amino acid or peptide acceptor, the co... | [
-0.041967932134866714,
-0.038112714886665344,
-0.02714940719306469,
0.010773759335279465,
0.017537754029035568,
-0.0013562818057835102,
0.03675960376858711,
0.018500838428735733,
-0.007958573289215565,
-0.006578915286809206,
0.028440376743674278,
-0.03129659593105316,
0.010976960882544518,
... |
PMID:7567 | Neurospora crassa glutamine synthetase. Purification by affinity chromatography and characterization of subunit structure. | Neurospora crassa glutamine synthetase was purified to homogeneity by a procedure based on affinity chromatography. The enzyme is adsorbed to a matrix of anthranilic acid bound to Sepharose and eluted with AMP. Different experimental approaches indicate that the enzyme has an octameric structure formed by subunits of i... | Neurospora crassa glutamine synthetase. Purification by affinity chromatography and characterization of subunit structure. Neurospora crassa glutamine synthetase was purified to homogeneity by a procedure based on affinity chromatography. The enzyme is adsorbed to a matrix of anthranilic acid bound to Sepharose and elu... | [
0.0026697502471506596,
-0.01947728917002678,
-0.0589514896273613,
-0.014435292221605778,
0.017573360353708267,
0.010033009573817253,
0.04412250593304634,
-0.023642702028155327,
-0.060453735291957855,
0.01692052371799946,
-0.00044951544259674847,
-0.08171911537647247,
-0.019928425550460815,
... |
PMID:7570 | Chromatographic behaviour of alkaloids on thin layers of cation exchangers. II. Alginic acid, Rexyn 102, Dowex 50-X4 and CMCNa. | The chromatographic behaviour of 48 alkaloids on cation exchangers with cellulose, paraffin and polystyrene matrices in both the acid and sodium salt forms has been investigated. Water-organic solvent mixtures, aqueous buffer solutions and organic and mineral acid solutions in both water and in aqueous-organic solvents... | Chromatographic behaviour of alkaloids on thin layers of cation exchangers. II. Alginic acid, Rexyn 102, Dowex 50-X4 and CMCNa. The chromatographic behaviour of 48 alkaloids on cation exchangers with cellulose, paraffin and polystyrene matrices in both the acid and sodium salt forms has been investigated. Water-organic... | [
-0.0321425162255764,
-0.00768600357696414,
-0.018457777798175812,
-0.0013346633641049266,
-0.01608818955719471,
0.03995073586702347,
0.02706303261220455,
0.02597249299287796,
-0.04725584760308266,
-0.022422898560762405,
-0.014768974855542183,
-0.0484188087284565,
-0.0165878813713789,
0.030... |
PMID:7569 | Membrane receptors for hormones and neurotransmitters. | Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoproteins, and in many cases appear to have more than one subun... | Membrane receptors for hormones and neurotransmitters. Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoprotein... | [
-0.004908575210720301,
-0.03438238799571991,
0.002265439834445715,
0.008249492384493351,
-0.04409326612949371,
-0.05270861089229584,
0.16637228429317474,
0.0005656445864588022,
-0.02155507728457451,
-0.029912859201431274,
-0.013814721256494522,
-0.047059595584869385,
0.051670391112565994,
... |
PMID:7571 | Prolactin secretion by metoclopramide in man. | Six men and nine women were given intravenous injections of 2.5 mg of metoclopramide to assess its potential as a stimulus to prolactin release. Following the administration of metoclopramide, there was prompt increase in serum prolactin to a peak response of 38.2 +/- 3.9 ng/ml in men and 103 +/- 10.2 ng/ml in women. T... | Prolactin secretion by metoclopramide in man. Six men and nine women were given intravenous injections of 2.5 mg of metoclopramide to assess its potential as a stimulus to prolactin release. Following the administration of metoclopramide, there was prompt increase in serum prolactin to a peak response of 38.2 +/- 3.9 n... | [
-0.020509013906121254,
0.03426992520689964,
0.021621504798531532,
0.025966499000787735,
-0.012894969433546066,
0.04485660046339035,
0.07388822734355927,
-0.033484816551208496,
-0.03435880318284035,
-0.05873473361134529,
0.006627012509852648,
-0.020762115716934204,
-0.0063076140359044075,
0... |
PMID:7572 | Deficient 17 beta-hydroxysteroid oxidoreductase activity in testes from a male pseudohermaphrodite. | 17beta-Hydroxysteroid oxidoreductase (17 beta-HOR) activity in testicular tissue from a male pseudohermaphrodite (MP) who had elevated plasma LH and androstenedione (A) levels, and normal dehydroepiandrosterone (DHA) levels was compared by in vitro studies to that of testicular tissue from a normal man. The 17 beta-HOR... | Deficient 17 beta-hydroxysteroid oxidoreductase activity in testes from a male pseudohermaphrodite. 17beta-Hydroxysteroid oxidoreductase (17 beta-HOR) activity in testicular tissue from a male pseudohermaphrodite (MP) who had elevated plasma LH and androstenedione (A) levels, and normal dehydroepiandrosterone (DHA) lev... | [
-0.026163315400481224,
0.0553218275308609,
-0.02107093669474125,
-0.013757276348769665,
0.0322054922580719,
-0.005980845540761948,
-0.004938127472996712,
-0.0027832812629640102,
-0.03895614296197891,
-0.07241540402173996,
0.00658054044470191,
-0.12162648141384125,
0.029117252677679062,
0.0... |
PMID:7573 | Counterimmunoelectrophoresis of staphylococcal antibody. | Modifications of the staphylococcal counterimmunoelectrophoresis technique were evaluated to determine how variations in the procedure affected results. Neither a buffer pH range of 7.8 to 9.0 nor buffer molarity of 0.015 or 0.025 when tested in combinations caused appreciable differences. However, use of different aga... | Counterimmunoelectrophoresis of staphylococcal antibody. Modifications of the staphylococcal counterimmunoelectrophoresis technique were evaluated to determine how variations in the procedure affected results. Neither a buffer pH range of 7.8 to 9.0 nor buffer molarity of 0.015 or 0.025 when tested in combinations caus... | [
-0.02433074824512005,
0.01839928887784481,
0.024476589635014534,
-0.01886807195842266,
0.03371500223875046,
-0.07472497969865799,
0.05173618718981743,
0.01658676005899906,
-0.03841817378997803,
-0.014074329286813736,
0.015938961878418922,
-0.06987070292234421,
0.013372490182518959,
0.06642... |
PMID:7574 | Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement. | Recent work has indicated that superoxide is involved in the manganese-stimulated oxidation of NADPH by crude granule preparations of guinea pig neutrophils. The characteristics of a model manganese-requiring NADPH-oxidizing system that employs a defined O2-generator have now been compared to the original neutrophil-gr... | Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement. Recent work has indicated that superoxide is involved in the manganese-stimulated oxidation of NADPH by crude granule preparations of guinea pig neutrophils. The characteris... | [
-0.08975634723901749,
0.017615195363759995,
-0.05720069259405136,
-0.019126618281006813,
0.05354877933859825,
0.02680141292512417,
0.04656607285141945,
0.04719480872154236,
-0.051714248955249786,
-0.03943553939461708,
-0.009793112985789776,
-0.027891989797353745,
0.02428559958934784,
0.056... |
PMID:7575 | Determinants of lung bacterial clearance in normal mice. | The determinants of the lung clearance of Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus were studied in normal mice after exposure to an aerosol of viable bacteria and 99mTc-labeled dead bacteria. The fraction of bacteria in lungs that remained viable 4 h after exposure we... | Determinants of lung bacterial clearance in normal mice. The determinants of the lung clearance of Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus were studied in normal mice after exposure to an aerosol of viable bacteria and 99mTc-labeled dead bacteria. The fraction of bac... | [
-0.026368016377091408,
0.04044186323881149,
0.0055506047792732716,
-0.009546848945319653,
0.09483669698238373,
-0.035912103950977325,
0.0715315192937851,
0.04434666037559509,
-0.0247749462723732,
0.021755198016762733,
-0.0010898906039074063,
-0.08830279111862183,
0.04189513251185417,
0.007... |
PMID:7576 | Alpha- and beta-adrenergic receptor blocking agents combined with a diuretic in the treatment of essential hypertension. | The antihypertensive efficacy and side effects of the combined therapy with propranolol, phenoxybenzamine, and hydrochlorothiazide were examined in 17 patients with moderate and moderately severe hypertension. Following a control period two to three weeks' duration, propranolol was started in nine patients as the sole ... | Alpha- and beta-adrenergic receptor blocking agents combined with a diuretic in the treatment of essential hypertension. The antihypertensive efficacy and side effects of the combined therapy with propranolol, phenoxybenzamine, and hydrochlorothiazide were examined in 17 patients with moderate and moderately severe hyp... | [
-0.03830253332853317,
0.053116947412490845,
0.00048662169137969613,
0.04645867273211479,
-0.025987451896071434,
-0.018749617040157318,
0.011665352620184422,
0.025342049077153206,
-0.02872438170015812,
-0.051048263907432556,
0.018727658316493034,
-0.0020097142551094294,
0.004003436770290136,
... |
PMID:7579 | Milk lipoprotein lipases: a review. | Lipoprotein lipase activity has been found in the milks from severals species where it is assumed to result from leakage from the mammary gland into milk. The function of the enzyme in the gland is apparently to assist in the transfer of blood lipoprotein triacylglycerol fatty acids into milk triacylglycerols. Bovine s... | Milk lipoprotein lipases: a review. Lipoprotein lipase activity has been found in the milks from severals species where it is assumed to result from leakage from the mammary gland into milk. The function of the enzyme in the gland is apparently to assist in the transfer of blood lipoprotein triacylglycerol fatty acids ... | [
0.02823401801288128,
-0.029318872839212418,
-0.03520882502198219,
0.01411950308829546,
-0.0017392425797879696,
-0.03811068832874298,
0.07181698083877563,
0.09264794737100601,
0.006834104657173157,
-0.008763891644775867,
-0.0025861714966595173,
-0.11907545477151871,
0.0030909315682947636,
-... |
PMID:7580 | Synthetic peptides for chymosin and pepsin assays: pH effect and pepsin independent-determination in mixtures. | Peptide I [H-Phe-Gly-His-Phe(NO2)-Phe-Ala-Phe-OMe] hydrolyzed by chymosin with kcat=.3+/-.3 s-1 and KM=7+/-3 mM (pH 4.7) inhibited competitively peptide II [H-Leu-Ser-Phe(NO2)-Nle-Ala-Leu-OMe] hydrolysis by chymosin with KI=.23 +/- .12 mM at pH 4.7. In reference conditions (.4 mM peptide, .01 M acetate buffer pH 4.7), ... | Synthetic peptides for chymosin and pepsin assays: pH effect and pepsin independent-determination in mixtures. Peptide I [H-Phe-Gly-His-Phe(NO2)-Phe-Ala-Phe-OMe] hydrolyzed by chymosin with kcat=.3+/-.3 s-1 and KM=7+/-3 mM (pH 4.7) inhibited competitively peptide II [H-Leu-Ser-Phe(NO2)-Nle-Ala-Leu-OMe] hydrolysis by ch... | [
-0.08374592661857605,
-0.03181638941168785,
-0.021601494401693344,
0.0011563438456505537,
0.045816417783498764,
-0.03384881839156151,
0.07633910328149796,
0.08450259268283844,
-0.018828323110938072,
-0.03416047990322113,
0.002288089133799076,
-0.09758780896663666,
0.019800085574388504,
0.0... |
PMID:7581 | Diet calcium and pH versus mineral balance in Holstein cows 84 days pre- to 2 days postpartum. | Sixteen dry Holstein cows were assigned four groups combining either .2 or 2.1% calcium and pH of either 4.5 or 6.1 in a 2 X 2 factorial arrangement of treatments to study the effect of diet calcium and acidity (pH) on voluntary intake of dry matter, mineral metabolism, and blood constituents. The 86-day experiment was... | Diet calcium and pH versus mineral balance in Holstein cows 84 days pre- to 2 days postpartum. Sixteen dry Holstein cows were assigned four groups combining either .2 or 2.1% calcium and pH of either 4.5 or 6.1 in a 2 X 2 factorial arrangement of treatments to study the effect of diet calcium and acidity (pH) on volunt... | [
-0.02006063424050808,
0.0006506930221803486,
-0.011747417040169239,
0.031147612258791924,
0.015608363784849644,
-0.04309014976024628,
0.021572060883045197,
0.054645709693431854,
-0.010384822264313698,
0.008291404694318771,
0.04001682624220848,
-0.1376621127128601,
0.03872156888246536,
0.02... |
PMID:7583 | The role of precipitins and complement activation in the etiology of allergic lung disease. | An experimental model of allergic lung disease has been described that is monitored by analysis of arterial oxygen tension following aerosol challenge with antigen. Rabbits immunized to a classical soluble antigen, human serum albumin (HSA), to the point where severe Arthus skin reactivity was demonstrable, were aeroso... | The role of precipitins and complement activation in the etiology of allergic lung disease. An experimental model of allergic lung disease has been described that is monitored by analysis of arterial oxygen tension following aerosol challenge with antigen. Rabbits immunized to a classical soluble antigen, human serum a... | [
-0.08992990851402283,
0.026926446706056595,
0.025489065796136856,
0.044446833431720734,
0.04554218053817749,
-0.02427486702799797,
0.14109596610069275,
0.008119430392980576,
-0.037494488060474396,
-0.021775290369987488,
-0.012194517999887466,
-0.09789596498012543,
-0.04963811859488487,
0.0... |
PMID:7584 | The effect of pertussis and beta adrenergic-blocking agents on mast cells. | Pertussis vaccine injected ip in doses known to cause hypersensitization resulted in a marked decrease in the number of mast cells from the peritoneal washings of rats and mice. A significant reduction was obtained as early as one day after pertussis injection of ten billion cells in rats and was marked after 5 to 7 da... | The effect of pertussis and beta adrenergic-blocking agents on mast cells. Pertussis vaccine injected ip in doses known to cause hypersensitization resulted in a marked decrease in the number of mast cells from the peritoneal washings of rats and mice. A significant reduction was obtained as early as one day after pert... | [
-0.024255719035863876,
-0.0029919221997261047,
-0.03138652443885803,
-0.024298982694745064,
0.00944571290165186,
-0.01982230320572853,
0.06013457849621773,
-0.0027159040328115225,
-0.06254877150058746,
-0.0543404184281826,
-0.004561133217066526,
-0.06780113279819489,
0.026731982827186584,
... |
PMID:7585 | Disodium cromoglycate in ragweed-allergic rhinitis. | This study was designed to test the effectiveness of disodium cromoglycate when compared to placebo in a double-blind study in patients with ragweed allergic rhinitis. Patients were selected on the basis of a clinical history and a 4+ reaction to the intradermal injection of water-soluble ragweed, 0.02 c.c. of 500 PNU/... | Disodium cromoglycate in ragweed-allergic rhinitis. This study was designed to test the effectiveness of disodium cromoglycate when compared to placebo in a double-blind study in patients with ragweed allergic rhinitis. Patients were selected on the basis of a clinical history and a 4+ reaction to the intradermal injec... | [
0.0022286109160631895,
-0.02119399979710579,
0.002866840921342373,
0.01781882718205452,
0.006852957885712385,
0.00871398113667965,
0.05491705238819122,
0.07359102368354797,
-0.12287566810846329,
-0.020301567390561104,
0.0018978967564180493,
-0.004064613953232765,
0.022726112976670265,
0.02... |
PMID:7588 | Piperacetazine versus thioridazine in the treatment of organic brain disease: a controlled double-blind study. | In a double-blind cross-over study, 50 geriatric patients with organic brain disease were divided into two groups. One group first received piperacetazine for 15 days and then thioridazine for 15 days. For the other group the sequence was reversed. Piperacetazine proved to be at least as effective as thioridazine and s... | Piperacetazine versus thioridazine in the treatment of organic brain disease: a controlled double-blind study. In a double-blind cross-over study, 50 geriatric patients with organic brain disease were divided into two groups. One group first received piperacetazine for 15 days and then thioridazine for 15 days. For the... | [
-0.027191899716854095,
-0.03164586052298546,
-0.062470100820064545,
0.05799602344632149,
-0.012534486129879951,
0.017454998567700386,
0.04179222136735916,
0.021370410919189453,
-0.05042288824915886,
-0.030118303373456,
-0.018881207332015038,
0.023062417283654213,
0.04117830842733383,
0.003... |
PMID:7629 | Duodenal immunoglobulin deficiency in graft versus host disease (GVHD) mice. | The small intestine is a well documented target organ in mouse and human GVHD, and diarrhea is a prominent part of the clinical GVHD syndrome. Although a plethora of systemic immune deficits has been documented in GVHD, the integrity of the small intestinal immune system has not been investigated. A correlation has not... | Duodenal immunoglobulin deficiency in graft versus host disease (GVHD) mice. The small intestine is a well documented target organ in mouse and human GVHD, and diarrhea is a prominent part of the clinical GVHD syndrome. Although a plethora of systemic immune deficits has been documented in GVHD, the integrity of the sm... | [
0.010508508421480656,
-0.00849864911288023,
0.019519973546266556,
0.0025980921927839518,
0.015391484834253788,
-0.04014468938112259,
0.05042793229222298,
0.10060790181159973,
-0.07231909781694412,
-0.057917095720767975,
-0.030843108892440796,
-0.07000218331813812,
0.02363630197942257,
-0.0... |
PMID:7630 | Partial regain of activity in heterologous recombinants of phosphorylcholine-binding M-components from different species. | Recombination experiments were performed with heavy and light chains derived from a Waldenström's IgM with specificity against phosphorylcholine. The recombinant molecules had an association constant for phosphorylcholine in the same order of magnitude as the native IgM; the number of binding sites at saturation was on... | Partial regain of activity in heterologous recombinants of phosphorylcholine-binding M-components from different species. Recombination experiments were performed with heavy and light chains derived from a Waldenström's IgM with specificity against phosphorylcholine. The recombinant molecules had an association constan... | [
-0.07145106792449951,
-0.025223884731531143,
-0.035769592970609665,
-0.05417861044406891,
-0.03126981854438782,
-0.04768940061330795,
0.04168824478983879,
0.03033384121954441,
-0.030485382303595543,
0.01239807903766632,
0.010184640064835548,
-0.03586834296584129,
-0.0024517446290701628,
0.... |
PMID:7631 | Neonatal infection with mouse thymic virus. Differential effects on T cells mediating the graft-versus-host reaction. | Neonatal infection with mouse thymic virus (TA), a murine herpes virus, produced extensive but temporary necrosis of the thymus which was maximal at 10 to 14 days of age. Studies of precursor and amplifier cells mediating graft-vs-host (GVH) reactivity of thymocytes, spleen cells (SC), and lymph node cells (LNC) of nor... | Neonatal infection with mouse thymic virus. Differential effects on T cells mediating the graft-versus-host reaction. Neonatal infection with mouse thymic virus (TA), a murine herpes virus, produced extensive but temporary necrosis of the thymus which was maximal at 10 to 14 days of age. Studies of precursor and amplif... | [
0.002119044540449977,
0.02193007990717888,
-0.019353602081537247,
0.049649495631456375,
0.003962344955652952,
0.015862835571169853,
0.05609086900949478,
0.060367029160261154,
-0.06677437573671341,
-0.010636193677783012,
0.033942729234695435,
-0.053596559911966324,
-0.0009534939890727401,
0... |
PMID:7589 | [Voluntary choice of sex. The present state of our knowledge]. | Whether we like it or not, the next demand that the modern couple will make after birth control will be voluntary selection of the sex of their babies. Furthermore, this selection does have an undoubted medical value in preventing certain sex-linked congenital or hereditary diseases. Many research workers have turned t... | [Voluntary choice of sex. The present state of our knowledge]. Whether we like it or not, the next demand that the modern couple will make after birth control will be voluntary selection of the sex of their babies. Furthermore, this selection does have an undoubted medical value in preventing certain sex-linked congeni... | [
-0.022496720775961876,
0.06825718283653259,
-0.010502059943974018,
-0.02906501479446888,
0.016866911202669144,
0.0833110511302948,
0.04222225770354271,
0.03824404999613762,
0.029314279556274414,
-0.0003234324976801872,
-0.010045042261481285,
-0.0203518308699131,
-0.04216715320944786,
0.007... |
PMID:7632 | Affinity chromatography of lipase with hydrophobic ligands coupled to cyanogen bromide-activated agarose. | The behavior of lipase produced by Pseudomans mephitica var. lipopytica toward hydrophobic residues coupled to spacer gels that were prepared by coupling a primary amine to CNBr-activated agarose, was studied. The lipase adsorbed on the ligand of a long unbranched aliphatic chain, a benzene ring, or deoxycholic acid wa... | Affinity chromatography of lipase with hydrophobic ligands coupled to cyanogen bromide-activated agarose. The behavior of lipase produced by Pseudomans mephitica var. lipopytica toward hydrophobic residues coupled to spacer gels that were prepared by coupling a primary amine to CNBr-activated agarose, was studied. The ... | [
-0.09240260720252991,
-0.006821496412158012,
-0.06982254981994629,
0.07058987766504288,
-0.012723339721560478,
-0.09280317276716232,
0.043137550354003906,
0.06278683990240097,
-0.05060943588614464,
-0.03818415105342865,
0.029960548505187035,
-0.037282224744558334,
-0.042754240334033966,
-0... |
PMID:7633 | Urticaria. | Urticaria is a problem often as vexing to the physician as to the patient. The approach to the patient with hives first demands a search for the etiology, whether endogenous and triggered by emotions or occult systemic disease, exogenous and triggered by allergy to inhaled or ingested antigens, or physical and due to a... | Urticaria. Urticaria is a problem often as vexing to the physician as to the patient. The approach to the patient with hives first demands a search for the etiology, whether endogenous and triggered by emotions or occult systemic disease, exogenous and triggered by allergy to inhaled or ingested antigens, or physical a... | [
-0.005483416840434074,
0.02443115785717964,
0.05926845967769623,
0.05122145265340805,
0.026264825835824013,
-0.03009015880525112,
0.07720942795276642,
0.05250462144613266,
-0.057152289897203445,
-0.05503816157579422,
0.03175228461623192,
-0.05986456945538521,
-0.008103779517114162,
0.04399... |
PMID:7635 | Effect of amiloride and some of its analogues of cation transport in isolated frog skin and thin lipid membranes. | The inhibition of short-circuit current (Isc) in isolated frog skin and the induction of surface potentials in lipid bilayer membranes produced by the diuretic drug amiloride and a number of its chemical analogues was studied. The major conclusions of our study are: (a) The charged form of amiloride is the biologically... | Effect of amiloride and some of its analogues of cation transport in isolated frog skin and thin lipid membranes. The inhibition of short-circuit current (Isc) in isolated frog skin and the induction of surface potentials in lipid bilayer membranes produced by the diuretic drug amiloride and a number of its chemical an... | [
-0.06676772236824036,
-0.06366343051195145,
-0.017945507541298866,
0.049592576920986176,
0.005482550710439682,
-0.04712073877453804,
0.03929900377988815,
0.03272606059908867,
-0.047007013112306595,
-0.045726582407951355,
0.05577272176742554,
-0.0767463818192482,
0.013886929489672184,
0.059... |
PMID:7636 | Studies on the rumen flagellate Sphaeromonas communis. | The rumen flagellate Sphaeromonas communis showed a significant increase in population density 1 to 2 h after the host sheep commenced feeding, followed by a reduction in numbers to the pre-feeding level after a further 2 to 3 h. The life-history of the organism was shown to consist of a motile flagellate which germina... | Studies on the rumen flagellate Sphaeromonas communis. The rumen flagellate Sphaeromonas communis showed a significant increase in population density 1 to 2 h after the host sheep commenced feeding, followed by a reduction in numbers to the pre-feeding level after a further 2 to 3 h. The life-history of the organism wa... | [
0.02135358937084675,
0.019027475267648697,
0.03194291144609451,
-0.008296174928545952,
0.055706292390823364,
0.02252093516290188,
-0.022567594423890114,
0.04308309406042099,
-0.00188450759742409,
0.025528347119688988,
0.015071925707161427,
-0.06784669309854507,
-0.0014617402339354157,
0.01... |
PMID:7637 | Influence of dilution rate on NAD(P) and NAD(P)H concentrations and ratios in a Pseudomonas sp. grown in continuous culture. | A freshwater Pseudomonas sp. was grown in continuous culture under steady-state conditions in L-lactate-, succinate-, glucose- or ammonium-limited media. Under carbon limitation, the NAD(H) (i.e. NAD + NADH) concentration of the organisms increased exponentially from approximately 2 to 7 mumol/g dry wt as the culture d... | Influence of dilution rate on NAD(P) and NAD(P)H concentrations and ratios in a Pseudomonas sp. grown in continuous culture. A freshwater Pseudomonas sp. was grown in continuous culture under steady-state conditions in L-lactate-, succinate-, glucose- or ammonium-limited media. Under carbon limitation, the NAD(H) (i.e.... | [
0.0023873576428741217,
0.027249261736869812,
-0.03192226588726044,
-0.005994672887027264,
0.06634482741355896,
-0.005118922330439091,
0.014079375192523003,
0.01389323640614748,
-0.050120800733566284,
-0.03867800906300545,
0.030345622450113297,
-0.05713491141796112,
0.05773824080824852,
0.0... |
PMID:7642 | Differences between the anorexic actions of amphetamine and fenfluramine--possible effects on hunger and satiety. | The inhition of feeding in rats brought about by amphetamine and fenfluramine was continuously monitored for periods of up to 24 h using a pellet detecting eatometer. For rats tested under conditions of food deprivation the two drugs gave rise to distinctive anorexic profiles: amphetamine delayed the onset of eating wh... | Differences between the anorexic actions of amphetamine and fenfluramine--possible effects on hunger and satiety. The inhition of feeding in rats brought about by amphetamine and fenfluramine was continuously monitored for periods of up to 24 h using a pellet detecting eatometer. For rats tested under conditions of foo... | [
-0.0029286236967891455,
-0.03608947992324829,
0.029772844165563583,
0.000034572691220091656,
-0.026041178032755852,
0.04277817904949188,
0.04616798087954521,
-0.01274087093770504,
-0.06373235583305359,
-0.0899062231183052,
-0.0066899447701871395,
-0.03178752586245537,
0.02752223052084446,
... |
PMID:7643 | Alpha-methyl derivatives of biogenic amines as inhibitors of monoamin oxidase. | The values of Km app and Vmax for three natural substrates of monoamine oxidase have been determined at various stages in the isolation of the enzyme from rat liver tissue. The results are consistent with the presence in the enzyme preparation of at least two distinct molecular forms of the enzyme. Using the alpha-meth... | Alpha-methyl derivatives of biogenic amines as inhibitors of monoamin oxidase. The values of Km app and Vmax for three natural substrates of monoamine oxidase have been determined at various stages in the isolation of the enzyme from rat liver tissue. The results are consistent with the presence in the enzyme preparati... | [
-0.06349064409732819,
0.014869539067149162,
0.002431705594062805,
0.000921776460018009,
0.023114539682865143,
0.026234813034534454,
0.08218493312597275,
0.009475506842136383,
-0.004610054660588503,
-0.019314570352435112,
0.013738779351115227,
-0.017085429280996323,
0.04233594611287117,
0.0... |
PMID:7644 | Comparative study of the effects of mianserin, a tetracyclic antidepressant, and of imipramine on uptake and release of neurotransmitters in synaptosomes. | The effects of mianserin, a tetracyclic antidepressant, on uptake and release of [3H]noradrenaline (3H-NA), [3H]dopamine (3H-DA), [3H]-5-hydroxytryptamine(3H-5-HT) and [3H]gamma-amino-butyric acid (3H-GABA) in synaptosomes from different areas of the rat brain were investigated in a comparative study with the tricyclic... | Comparative study of the effects of mianserin, a tetracyclic antidepressant, and of imipramine on uptake and release of neurotransmitters in synaptosomes. The effects of mianserin, a tetracyclic antidepressant, on uptake and release of [3H]noradrenaline (3H-NA), [3H]dopamine (3H-DA), [3H]-5-hydroxytryptamine(3H-5-HT) a... | [
0.004392560105770826,
-0.005648859776556492,
0.00678023137152195,
0.053584735840559006,
0.00925379991531372,
0.026512909680604935,
0.0620863139629364,
0.012272655963897705,
-0.010579641908407211,
-0.09819526970386505,
0.012751027941703796,
-0.02443484589457512,
0.03249423950910568,
0.02827... |
PMID:7645 | Adrenergic responses of the rabbit stomach serosal strip and their modification by monoamine oxidase inhibitors and anti-adrenergic drugs. | The rabbit stomach serosal strip, was found to contract to adrenaline and noradrenaline but not to isoprenaline. The contractile response could be totally abolished by phenoxybenzamine but was not influenced by propranolol, indicating that the preparation has almost exclusively alpha-adrenoceptors. The responses to adr... | Adrenergic responses of the rabbit stomach serosal strip and their modification by monoamine oxidase inhibitors and anti-adrenergic drugs. The rabbit stomach serosal strip, was found to contract to adrenaline and noradrenaline but not to isoprenaline. The contractile response could be totally abolished by phenoxybenzam... | [
-0.03817629814147949,
0.0015450231730937958,
-0.02997216023504734,
0.07799450308084488,
0.002197279129177332,
-0.0010349161457270384,
0.06362079083919525,
0.026904627680778503,
-0.05304009094834328,
-0.04885539039969444,
-0.03036535531282425,
-0.04125938192009926,
-0.01696506142616272,
0.1... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.