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PMID:9181 | Composition of crop and gizzard contents in the laying hen. | Crop and gizzard contents were analysed at six stages of egg formation. 2. The crop was empty during the day and full during the night while the gizzard contained a constant amount of dry matter. The water content of the crop did not change but that of the gizzard was at a minimum just after the ovulation and at a maxi... | Composition of crop and gizzard contents in the laying hen. Crop and gizzard contents were analysed at six stages of egg formation. 2. The crop was empty during the day and full during the night while the gizzard contained a constant amount of dry matter. The water content of the crop did not change but that of the giz... | [
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PMID:9182 | [Guanyl cyclase activities in clonal lines of cultured astroblasts and neuroblasts]. | Guanylate cyclase was found to be present in a number of astroblast and neuroblast clones. No correlations were observed between the enzyme activity and the nature of the clone. The enzyme shows a requirement for manganese ions and is stimulated by calcium. When the astroblast clone NN is cultured together with the neu... | [Guanyl cyclase activities in clonal lines of cultured astroblasts and neuroblasts]. Guanylate cyclase was found to be present in a number of astroblast and neuroblast clones. No correlations were observed between the enzyme activity and the nature of the clone. The enzyme shows a requirement for manganese ions and is ... | [
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PMID:9183 | [Immunosuppressive role of the liver in the graft versus host reaction]. | The ability of the liver to reduce the intensity of the graft versus host (GVH) reaction has been investigated in F1 hybrid rats implanted with parental lymph nodes. Intrahepatic and intrarenal tissue implantations were compared using classical GVH criteria. The intrahepatic implantation of lymph nodes suppress the mor... | [Immunosuppressive role of the liver in the graft versus host reaction]. The ability of the liver to reduce the intensity of the graft versus host (GVH) reaction has been investigated in F1 hybrid rats implanted with parental lymph nodes. Intrahepatic and intrarenal tissue implantations were compared using classical GV... | [
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PMID:9184 | [Extraction of LHRH in human urine: study of the extraction of labelled synthetic hormone]. | A method of extraction of synthetic LHRH is studied in human urines, using porous glass (Spherosil) and methanol. In the defined conditions the yield is greeter than 80%. It appears that the method is reproducible. The recovery varies essentially with the quantity of Spherosil and the pH of methanal. The use of methano... | [Extraction of LHRH in human urine: study of the extraction of labelled synthetic hormone]. A method of extraction of synthetic LHRH is studied in human urines, using porous glass (Spherosil) and methanol. In the defined conditions the yield is greeter than 80%. It appears that the method is reproducible. The recovery ... | [
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PMID:9185 | [Applications of the extraction and of the radioimmunoassay of LH-RH in human urine]. | The existence of endogenous LH RH like immunoreactivity is shown in human urines after appropriate extraction, bu the radioimmunoassay of LH RH. In normaly cycling and menopausal women the quantities of endogenous hormone found in urines are greater after acid extraction than those found after extraction at pH 7. Furth... | [Applications of the extraction and of the radioimmunoassay of LH-RH in human urine]. The existence of endogenous LH RH like immunoreactivity is shown in human urines after appropriate extraction, bu the radioimmunoassay of LH RH. In normaly cycling and menopausal women the quantities of endogenous hormone found in uri... | [
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PMID:9186 | [Reduction of exercise inudced hyperventilation by blocking beta adrenergic receptors]. | In normal subjects, beta-adrenergic blockage by propranolol or pindolol reduces exercise hyperventilation (40 to 60% VO2 max). | [Reduction of exercise inudced hyperventilation by blocking beta adrenergic receptors]. In normal subjects, beta-adrenergic blockage by propranolol or pindolol reduces exercise hyperventilation (40 to 60% VO2 max). | [
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PMID:9187 | [Splenomegaly reaction of the chick embryo following chorio-allantoid graft of chicken-spleen fragments]. | The spleen enhancement reaction of the chick embryo, following the insertion (grafting or injection procedure) of homologous spleen cells is one of the results of the graft-versus-host reaction (G.V.H. reaction). Irrespective of the usual kinds of G.V.H. reaction measured, it has been proved that the relation between t... | [Splenomegaly reaction of the chick embryo following chorio-allantoid graft of chicken-spleen fragments]. The spleen enhancement reaction of the chick embryo, following the insertion (grafting or injection procedure) of homologous spleen cells is one of the results of the graft-versus-host reaction (G.V.H. reaction). I... | [
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PMID:9188 | [Influence of metabolic alkalosis on adrenaline hyperglycemia of the dog]. | The metabolic alkalosis, induced by the administration bicarbonate, reduces adrenaline hyperglycemia in fasted dog. | [Influence of metabolic alkalosis on adrenaline hyperglycemia of the dog]. The metabolic alkalosis, induced by the administration bicarbonate, reduces adrenaline hyperglycemia in fasted dog. | [
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PMID:9189 | Purification and characterization of tonin. | Tonin was purified from rat submaxillary glands by differential centrifugation, ammonium sulphate precipitation, gel filtration on Sephadex G150, and by ion-exchange chromatography on DEAE-cellulose, phospho-cellulose, SP-Sephadex C25, and SP-Sephadex C50. Purified tonin was shown to be homogeneous by analytical electr... | Purification and characterization of tonin. Tonin was purified from rat submaxillary glands by differential centrifugation, ammonium sulphate precipitation, gel filtration on Sephadex G150, and by ion-exchange chromatography on DEAE-cellulose, phospho-cellulose, SP-Sephadex C25, and SP-Sephadex C50. Purified tonin was ... | [
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PMID:9191 | A particulate chitin synthase from Aspergillus flavus Link: the properties, location, and levels of activity in mycelium and regenerating protoplast preparations. | Chitin synthase (ED 2.4.1.16) has been characterized in Aspergillus flavus. A K(m) value of 2.5 m(M) was obtained for the substrate UDPGlcNAc. The enzyme had a requirement for GlcNAc, and Mg2+ and activity was increased in the presence of soluble chitodextrins F1 and F2. The optimum activity was obtained using Tris--HC... | A particulate chitin synthase from Aspergillus flavus Link: the properties, location, and levels of activity in mycelium and regenerating protoplast preparations. Chitin synthase (ED 2.4.1.16) has been characterized in Aspergillus flavus. A K(m) value of 2.5 m(M) was obtained for the substrate UDPGlcNAc. The enzyme had... | [
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PMID:9192 | Stable L-forms of Clostridium perfringens and their growth on glass surfaces. | L-forms of Clostridium perfringens were induced in brain heart infusion broth containing 10% sucrose and 2 units of penicillin. After a few hours of growth, spheroplasts, granules, and elongated bacilli were apparent. At 24-h intervals, serial subcultures were made in the above medium which resulted in a culture compos... | Stable L-forms of Clostridium perfringens and their growth on glass surfaces. L-forms of Clostridium perfringens were induced in brain heart infusion broth containing 10% sucrose and 2 units of penicillin. After a few hours of growth, spheroplasts, granules, and elongated bacilli were apparent. At 24-h intervals, seria... | [
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PMID:9193 | Competition between Phytophthora cinnamomi and Trichoderma spp. in autoclaved soil. | Results from analyses of beta-glucosidase (EC 3.2.1.21) and phosphatase (EC 3.1.3.1;EC 3.1.3.2) activities indicated that presence of a Trichoderma isolate reduced development of Phytophthora cinnamomi. It was also observed that P. cinnamomi was more competitive in coinoculated cultures than in cultures where Trichoder... | Competition between Phytophthora cinnamomi and Trichoderma spp. in autoclaved soil. Results from analyses of beta-glucosidase (EC 3.2.1.21) and phosphatase (EC 3.1.3.1;EC 3.1.3.2) activities indicated that presence of a Trichoderma isolate reduced development of Phytophthora cinnamomi. It was also observed that P. cinn... | [
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PMID:9194 | Antifungal properties of alpha,omega-alkanedicarboxylic acids and their dimethyl esters. | Thirteen alpha, omega-alkanedicarboxylic acids (C2-C12, C14, and C16) and their dimethyl esters were tested against Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabourauc dextrose agar at pH 4.0 AND 5.6. Toxicity to Canadida albicans, Trichophyton mentagrophytes, and Mucor mucedo was determined ... | Antifungal properties of alpha,omega-alkanedicarboxylic acids and their dimethyl esters. Thirteen alpha, omega-alkanedicarboxylic acids (C2-C12, C14, and C16) and their dimethyl esters were tested against Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabourauc dextrose agar at pH 4.0 AND 5.6. Tox... | [
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PMID:9197 | Tryptophanyl and carboxylic acid residues in the active centre of glucoamylase I from Aspergillus niger. | The pH-dependence of the photo-oxidation of L-tryptophan, in the presence of Rose Bengal and Methylene Blue, has been investigated. True, initial rate constants were determined in order to circumvent errors due to secondary processes. Photo-oxidation of glycoamylase I from A. niger in the presence of Methylene Blue or ... | Tryptophanyl and carboxylic acid residues in the active centre of glucoamylase I from Aspergillus niger. The pH-dependence of the photo-oxidation of L-tryptophan, in the presence of Rose Bengal and Methylene Blue, has been investigated. True, initial rate constants were determined in order to circumvent errors due to s... | [
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PMID:9198 | Production and purification of two hemicellulases from Cephalosporium sacchari. | The production of extracellular hemicellulases by the fungus Cephalosporium sacchari was studied in the presence of various sources of carbon and at various initial pH values and temperatures. Hemicellulose B and holocellulose from spear grass (Heteropogon contortus) were the best sources of carbon, and the optimum tem... | Production and purification of two hemicellulases from Cephalosporium sacchari. The production of extracellular hemicellulases by the fungus Cephalosporium sacchari was studied in the presence of various sources of carbon and at various initial pH values and temperatures. Hemicellulose B and holocellulose from spear gr... | [
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PMID:9199 | Bromine oxidation of methyl alpha- and beta-pyranosides of D-galactose, D-glucose, and D-mannose. | Methyl alpha- and beta-pyranosides of D-galactose, D-glucose, and D-mannose have been oxidized with bromine in aqueous solution at various pH values. The resulting keto glycosides were converted into their more-stable O-methyloxime derivatives which were characterized by spectroscopy and chromatography. Oxidation at a ... | Bromine oxidation of methyl alpha- and beta-pyranosides of D-galactose, D-glucose, and D-mannose. Methyl alpha- and beta-pyranosides of D-galactose, D-glucose, and D-mannose have been oxidized with bromine in aqueous solution at various pH values. The resulting keto glycosides were converted into their more-stable O-me... | [
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PMID:9200 | Multiple forms of DNA-dependent DNA polymerase during early development and in somatic cells of Xenopus laevis. | Four distinct DNA-dependent DNA polymerase activities (DNA polymerases I, II, III and IV according to the order of elution from a DEAE column) have been separated from extracts of unfertilized Xenopus laevis eggs. The same activities, on the basis of their chromatographic properties, template specificities and sediment... | Multiple forms of DNA-dependent DNA polymerase during early development and in somatic cells of Xenopus laevis. Four distinct DNA-dependent DNA polymerase activities (DNA polymerases I, II, III and IV according to the order of elution from a DEAE column) have been separated from extracts of unfertilized Xenopus laevis ... | [
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PMID:9204 | [Ionic control of biochemical reactions]. | It is shown that pH and ionic strength are tightly interdependent in cytochrome oxidase activity at the level of inner membranes of the mitochondrion, as a direct consequence of the polyanionic environment of this enzyme. Application of polyelectrolyte theory explains a number of biochemical reactions controlled by ion... | [Ionic control of biochemical reactions]. It is shown that pH and ionic strength are tightly interdependent in cytochrome oxidase activity at the level of inner membranes of the mitochondrion, as a direct consequence of the polyanionic environment of this enzyme. Application of polyelectrolyte theory explains a number ... | [
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PMID:9208 | Oxidation of lactate by human serum. | The oxidation of lactate by lactate dehydrogenase of human serum is described, and the kinetics of the reaction are examined. It seems that at higher pH values which are optimal for the faster moving isoenzymes of lactate dehydrogenase, slower moving entities show only a part of their activity. In contrast, M type isoe... | Oxidation of lactate by human serum. The oxidation of lactate by lactate dehydrogenase of human serum is described, and the kinetics of the reaction are examined. It seems that at higher pH values which are optimal for the faster moving isoenzymes of lactate dehydrogenase, slower moving entities show only a part of the... | [
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PMID:9209 | Isoelectric focusing of spectrin components in hereditary spherocytosis. | 1. By isoelectric focusing in 8 M urea, spectrin purified from normal human erythrocytes was resolved into 12 to 15 peptide bands differing by their isoelectric point. Most of them were focused between pH 6.4 and 5.2, one at pH 8.7 and some minor components between pH 7.4 and 6.8. 2. The results were not influenced by ... | Isoelectric focusing of spectrin components in hereditary spherocytosis. 1. By isoelectric focusing in 8 M urea, spectrin purified from normal human erythrocytes was resolved into 12 to 15 peptide bands differing by their isoelectric point. Most of them were focused between pH 6.4 and 5.2, one at pH 8.7 and some minor ... | [
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PMID:9210 | Isolation and characterization of isoenzymes of human salivary and pancreatic alpha-amylase. | Human salivary and pancreatic alpha-amylase (1,4-glucan 4-glucanohydrolase, EC 3.2.1.1) were separated by electrofocusing. In the first case we obtained six isoenzymes with isoelectric points of pH 5.70, 5.72, 6.23, 6.32, 6.73 and 6.88. Human pancreatic alpha-amylase has been separated into eight isoenzymes with isoele... | Isolation and characterization of isoenzymes of human salivary and pancreatic alpha-amylase. Human salivary and pancreatic alpha-amylase (1,4-glucan 4-glucanohydrolase, EC 3.2.1.1) were separated by electrofocusing. In the first case we obtained six isoenzymes with isoelectric points of pH 5.70, 5.72, 6.23, 6.32, 6.73 ... | [
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PMID:9211 | Determination of serum urea by mass fragmentography. | A mass fragmentographic method of high accuracy for determination of serum urea is described. A fixed amount of [15N2]urea is added to a fixed amount of serum, then the urea is converted into 5,5-diallyl barbituric acid by coupling with diallyl malonic acid diethyl ester. The barbiturate is then transferred from an alk... | Determination of serum urea by mass fragmentography. A mass fragmentographic method of high accuracy for determination of serum urea is described. A fixed amount of [15N2]urea is added to a fixed amount of serum, then the urea is converted into 5,5-diallyl barbituric acid by coupling with diallyl malonic acid diethyl e... | [
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PMID:9212 | Modification of neonatal screening test for erythrocyte glucose-6-phosphate dehydrogenase deficiency. | An improved technique is proposed for detecting G6PD deficiency on dried blood. A simple and rapid ascending chromatography of NADPH makes it possible to differentiate the false positives, too frequently found with Beutler's spot test (1968). | Modification of neonatal screening test for erythrocyte glucose-6-phosphate dehydrogenase deficiency. An improved technique is proposed for detecting G6PD deficiency on dried blood. A simple and rapid ascending chromatography of NADPH makes it possible to differentiate the false positives, too frequently found with Beu... | [
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PMID:9213 | Lysyl oxidase activity in human normal skins and postburn scars. | Lysyl oxidase activity of human normal skins derived from the frontal thighs of 33 subjects showed large variations and the mean value was 11 455 +/- 7 172 (S.D.) cpm/g of wet weight tissue. The age of lesion affected the lysyl oxidase activity in postburn scars. Granulation tissues showed a fairly low activity; howeve... | Lysyl oxidase activity in human normal skins and postburn scars. Lysyl oxidase activity of human normal skins derived from the frontal thighs of 33 subjects showed large variations and the mean value was 11 455 +/- 7 172 (S.D.) cpm/g of wet weight tissue. The age of lesion affected the lysyl oxidase activity in postbur... | [
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PMID:9214 | Sensitive radiochemical esterolytic assays for urokinase. | Two radiochemical esterolytic assays for urokinase are described. One assay is based on the urokinase-dependent hydrolysis of Nalpha-acetyl-glycyl-L-lysine [3H]methyl ester and the other on the urokinase-dependent activation of plasminogen and assay of generated plasmin with Nalpha-tosyl-L-arginine [3H]methyl ester. Th... | Sensitive radiochemical esterolytic assays for urokinase. Two radiochemical esterolytic assays for urokinase are described. One assay is based on the urokinase-dependent hydrolysis of Nalpha-acetyl-glycyl-L-lysine [3H]methyl ester and the other on the urokinase-dependent activation of plasminogen and assay of generated... | [
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PMID:9215 | Titration of human placental alkaline phosphatase with radioactive orthophosphate. | Human placental alkaline phosphatase incorporates radioactive phosphate specifically and covalently at acid pH. By titration of solutions of the purified enzyme with radioactive orthophosphate, the enzyme was shown to incorporate up to 2 phosphate groups per molecule. No evidence was found to suggest that the two sites... | Titration of human placental alkaline phosphatase with radioactive orthophosphate. Human placental alkaline phosphatase incorporates radioactive phosphate specifically and covalently at acid pH. By titration of solutions of the purified enzyme with radioactive orthophosphate, the enzyme was shown to incorporate up to 2... | [
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PMID:9216 | Degradation of arylsulfate by hepatic microsomes. | The enzyme liberated by some treatments and the changes in arylsulfatase C activity in chronic hepatic damage were investigated in rat liver. 1. The enzyme activity liberated by ultrasound was the highest in the conditions studied. 2. Arylsulfatase C was assayed using p-nitrophenyl sulfate in 0.25 M Tris/acetate buffer... | Degradation of arylsulfate by hepatic microsomes. The enzyme liberated by some treatments and the changes in arylsulfatase C activity in chronic hepatic damage were investigated in rat liver. 1. The enzyme activity liberated by ultrasound was the highest in the conditions studied. 2. Arylsulfatase C was assayed using p... | [
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PMID:9217 | Ultramicromethod for the determination of human arginase in the presence of urea. | A technique for arginase determination in body fluids in the presence of urea is described. [14C]Arginine is hydrolysed by arginase to [14C]urea and ornithine. [14C]Urea is separated with paper chromatography and measured in a liquid scintillation counter. The experimental conditions including the pH, substrate concent... | Ultramicromethod for the determination of human arginase in the presence of urea. A technique for arginase determination in body fluids in the presence of urea is described. [14C]Arginine is hydrolysed by arginase to [14C]urea and ornithine. [14C]Urea is separated with paper chromatography and measured in a liquid scin... | [
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PMID:9218 | Increased serum gamma-glutamyltransferase in hypertriglyceridemia: comparison with serum pseudocholinesterase. | Both gamma-glutamyltransferase (gammaGT) and pseudocholinesterase (PCE) were found to be increased in hypertriglyceridemic subjects. High values of gammaGT were noted in alcoholic subjects and especially in those with either increased serum triglyceride or alanine aminotransferase higher than 16 mU/ml, while PCE was no... | Increased serum gamma-glutamyltransferase in hypertriglyceridemia: comparison with serum pseudocholinesterase. Both gamma-glutamyltransferase (gammaGT) and pseudocholinesterase (PCE) were found to be increased in hypertriglyceridemic subjects. High values of gammaGT were noted in alcoholic subjects and especially in th... | [
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PMID:9219 | Circulating tissue antigens. III. Identification and characterization of antigens of limited and of wide body is distribution in human gall bladder bile. Presence in serum of patients with acute hepatitis. | Three antigens shared by bile and tissues (BT-1, BT-2 and BT-3) and one shared by bile and saliva (BA) were identified in human gallbladder bile by immunodiffusion. The former were detected in all bile specimens examined, whereas the latter was detected only in half. BT-1 was limited in distribution to kidney, urine an... | Circulating tissue antigens. III. Identification and characterization of antigens of limited and of wide body is distribution in human gall bladder bile. Presence in serum of patients with acute hepatitis. Three antigens shared by bile and tissues (BT-1, BT-2 and BT-3) and one shared by bile and saliva (BA) were identi... | [
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PMID:9221 | Generation of ammonia from non-urea sources in a faecal incubation system. | 1. A 25% faecal suspension in sodium chloride solution, incubated anaerobically at 37 degrees C for 48 h, showed excellent survival of all the main groups of faecal bacteria. 2. All faecal incubation systems studied generated large amounts of ammonia, particularly those in which bacterial counts fell during incubation.... | Generation of ammonia from non-urea sources in a faecal incubation system. 1. A 25% faecal suspension in sodium chloride solution, incubated anaerobically at 37 degrees C for 48 h, showed excellent survival of all the main groups of faecal bacteria. 2. All faecal incubation systems studied generated large amounts of am... | [
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PMID:9222 | The effect of pH on folic acid absorption in man. | 1. Pteroylmonoglutamic acid (PteGlu) absorption has been measured by using the technique of small-intestinal perfusion with tritiated PteGlu in normal subjects and in patients with coeliac disease. 2. At similar intrajejunal pH, patients with untreated coeliac disease have significantly less PTEGlu than normal subjects... | The effect of pH on folic acid absorption in man. 1. Pteroylmonoglutamic acid (PteGlu) absorption has been measured by using the technique of small-intestinal perfusion with tritiated PteGlu in normal subjects and in patients with coeliac disease. 2. At similar intrajejunal pH, patients with untreated coeliac disease h... | [
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PMID:9268 | The function of a psychiatric unit in a general hospital -- a five year experience. | The author reviews his five years experience with a psychiatric unit in a general hospital. He reviews the American Literature noting such units are thought to be important. There has been no discussion of the community roles of such units. From his experience, he recommends such units play a limited but specific funct... | The function of a psychiatric unit in a general hospital -- a five year experience. The author reviews his five years experience with a psychiatric unit in a general hospital. He reviews the American Literature noting such units are thought to be important. There has been no discussion of the community roles of such un... | [
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PMID:9270 | Antihistamines: pharmacology and clinical use. | Antihistamines are a diverse group of drugs which possess the ability to inhibit various histaminic actions. By and large, they bear a certain structural resemblance to histamine, and act principally to prevent histamine-receptor interaction through competition with histamine for histamine receptors. Consequently, they... | Antihistamines: pharmacology and clinical use. Antihistamines are a diverse group of drugs which possess the ability to inhibit various histaminic actions. By and large, they bear a certain structural resemblance to histamine, and act principally to prevent histamine-receptor interaction through competition with histam... | [
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PMID:9273 | Quantitative study of secondary structure of histones H1, H2A, and H4 in solution by infrared spectroscopy. | The secondary structure of histones H1, H2A, and H4 (F1, F2a2, and F2a1) has been quantitatively studied in heavy water (2H2O) solutions in a wide range of histone concentration, p2H, and concentration of sodium chloride using an improved infrared spectroscopy method. Under all conditions there are about 5--10% of alph... | Quantitative study of secondary structure of histones H1, H2A, and H4 in solution by infrared spectroscopy. The secondary structure of histones H1, H2A, and H4 (F1, F2a2, and F2a1) has been quantitatively studied in heavy water (2H2O) solutions in a wide range of histone concentration, p2H, and concentration of sodium ... | [
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PMID:9274 | Photolysis of desmosine and isodesmosine by ultraviolet light. | 1. Desmosine and isodesmosine were separated by ion-exchange and paper chromatography, after acid hydrolysis of purified elastin from beef ligamentum nuchae. The fractions obtained by ion-exchange chromatography were clearly mixtures of related compounds. The desmosine fraction could be resolved into seven compounds an... | Photolysis of desmosine and isodesmosine by ultraviolet light. 1. Desmosine and isodesmosine were separated by ion-exchange and paper chromatography, after acid hydrolysis of purified elastin from beef ligamentum nuchae. The fractions obtained by ion-exchange chromatography were clearly mixtures of related compounds. T... | [
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PMID:9275 | Effect of inhibitors on the substrate-dependent quenching of 9-aminoacridine fluorescence in inside-out membrane vesicles of Escherichia coli. | The effect of various inhibitors on the substrate-dependent quenching of the fluorescence of 9-aminoacridine was measured in inside-out membrane vesicles of Escherichia coli. The rate of fluorescence quenching in the presence of inhibitors was dependent on the rate of electron transfer through the respiratory chain wit... | Effect of inhibitors on the substrate-dependent quenching of 9-aminoacridine fluorescence in inside-out membrane vesicles of Escherichia coli. The effect of various inhibitors on the substrate-dependent quenching of the fluorescence of 9-aminoacridine was measured in inside-out membrane vesicles of Escherichia coli. Th... | [
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PMID:9276 | 8-Azidoacenine analogs of NAD+ and FAD. Synthesis and coenzyme properties with NAD+-dependent and FAD-dependent enzymes. | The synthesis and purification of the 8-azidoadenine analogs of NAD+ (azido-NAD+) and FAD (AZIDO-FAD) from 8-azidoadenosine 5'-phosphate and NMN+ or FMN, respectively, is described. The coenzyme analogs are characterized by absorption, nuclear magnetic resonance and circular dichroism spectra. The two latter methods in... | 8-Azidoacenine analogs of NAD+ and FAD. Synthesis and coenzyme properties with NAD+-dependent and FAD-dependent enzymes. The synthesis and purification of the 8-azidoadenine analogs of NAD+ (azido-NAD+) and FAD (AZIDO-FAD) from 8-azidoadenosine 5'-phosphate and NMN+ or FMN, respectively, is described. The coenzyme anal... | [
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PMID:9277 | Glutathione reductase from human erythrocytes. Catalytic properties and aggregation. | The catalytic properties of glutathione reductase from human erythrocytes have been studied over a range of buffer conditions and substrate concentrations. This study provides optimal conditions for determining the basic kinetic parameters of the enzyme. The catalytic behaviour of glutathione reductase is consistent wi... | Glutathione reductase from human erythrocytes. Catalytic properties and aggregation. The catalytic properties of glutathione reductase from human erythrocytes have been studied over a range of buffer conditions and substrate concentrations. This study provides optimal conditions for determining the basic kinetic parame... | [
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PMID:9278 | Phosphate binding to chromatophores of Rhodospirillum rubrum. | Equilibrium dialysis has been used to determine the binding of phosphate to chromatophores of Rhodospirillum rubrum. Assuming a complete exchange of the added 32Pi with endogenous phosphate, the saturation with phosphate retained in any form by chromatophores was reached at about 20 nmoles Pi per mg of bacteriochloroph... | Phosphate binding to chromatophores of Rhodospirillum rubrum. Equilibrium dialysis has been used to determine the binding of phosphate to chromatophores of Rhodospirillum rubrum. Assuming a complete exchange of the added 32Pi with endogenous phosphate, the saturation with phosphate retained in any form by chromatophore... | [
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PMID:9279 | The role of interchain disulphide bridges in the conformational stability of human immunoglobulin G1 subclass. Hydrogen-deuterium exchange studies. | The hydrogen-deuterium exchange data of human immunoglobulin G1 (IgG1) are interpreted by assuming fast fluctuations of the protein conformation, through which the peptide groups become exposed to the solvent. The probability of solvent exposure of peptide hydrogens reflects a rather loose conformation for native IgG i... | The role of interchain disulphide bridges in the conformational stability of human immunoglobulin G1 subclass. Hydrogen-deuterium exchange studies. The hydrogen-deuterium exchange data of human immunoglobulin G1 (IgG1) are interpreted by assuming fast fluctuations of the protein conformation, through which the peptide ... | [
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PMID:9280 | Equilibrium studies on the refolding and reactivation of rabbit-muscle aldolase after acid dissociation. | Dissociation, denaturation, and deactivation of aldolase from rabbit muscle in the acid pH range have been investigated using sedimentation analysis, fluorescence, circular dichroism, and activity tests. Under comparable experimental conditions the pH-dependent profiles of deactivation and denaturation parallel the dis... | Equilibrium studies on the refolding and reactivation of rabbit-muscle aldolase after acid dissociation. Dissociation, denaturation, and deactivation of aldolase from rabbit muscle in the acid pH range have been investigated using sedimentation analysis, fluorescence, circular dichroism, and activity tests. Under compa... | [
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PMID:9281 | The non-convalent binding of small molecules by ligandin. Interactions with steroids and their conjugates, fatty acids, bromosulphophthalein carcinogens, glutathione and realted compounds. | 1. Equilibrium dialysis studies have been made of the binding of a number of small molecules by rat ligandin. Direct measurements of binding together with competition experiments indicated that bromosulphophthalein, oestrone sulphate and dehydroepiandrosterone sulphate each bind at the same single primary binding site ... | The non-convalent binding of small molecules by ligandin. Interactions with steroids and their conjugates, fatty acids, bromosulphophthalein carcinogens, glutathione and realted compounds. 1. Equilibrium dialysis studies have been made of the binding of a number of small molecules by rat ligandin. Direct measurements o... | [
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PMID:9282 | Specificity and properties of the destabilization, induced by initiation factor IF-3, of ternary complexes of the 30-S ribosomal subunit, aminoacyl-tRNA and polynucleotides. | Initiation factor IF-3 causes the destabilization of preformed ternary complexes of 30-S ribosomal subunit, codons and aminoacyl-tRNAs or peptidyl-tRNA. This destabilization is dilution-dependent and affects all ternary complexes with the exception of those containing the initiator fMet-tRNA, which remain more resistan... | Specificity and properties of the destabilization, induced by initiation factor IF-3, of ternary complexes of the 30-S ribosomal subunit, aminoacyl-tRNA and polynucleotides. Initiation factor IF-3 causes the destabilization of preformed ternary complexes of 30-S ribosomal subunit, codons and aminoacyl-tRNAs or peptidyl... | [
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PMID:9283 | Amino-acid sequence of a coelenterate toxin: toxin II from Anemonia sulcata. | Toxin II from Anemonia sulcata, the main component of the sea anemone venom, consists of 47 amino acid residues which are interconnected by three disulfide bridges. The S-aminoethylated polypeptide was coupled to activated glass beads and sequenced to position 33 by automated solid-phase Edman degradation. Blanks arisi... | Amino-acid sequence of a coelenterate toxin: toxin II from Anemonia sulcata. Toxin II from Anemonia sulcata, the main component of the sea anemone venom, consists of 47 amino acid residues which are interconnected by three disulfide bridges. The S-aminoethylated polypeptide was coupled to activated glass beads and sequ... | [
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PMID:9284 | The role of lysine-41 in ribonuclease A studied by proton-magnetic-resonance spectroscopy of guanidinated ribonuclease A. | Ribonuclease A has been guanidinated at the lysine residues and the nona-guanidinated and deca-guanidinated (fully substituted) products separated. In confirmation of an earlier report by Glick and Barnard (1970), it has been shown by chemical procedures that the former derivative is not reacted at lysine-41. Guanidina... | The role of lysine-41 in ribonuclease A studied by proton-magnetic-resonance spectroscopy of guanidinated ribonuclease A. Ribonuclease A has been guanidinated at the lysine residues and the nona-guanidinated and deca-guanidinated (fully substituted) products separated. In confirmation of an earlier report by Glick and ... | [
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PMID:9285 | Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo. | It was demonstrated that an enzyme system(s) extracted from etiolated seedlings of Stizolobium hassjoo catalyzed the conversion of L-dihydroxyphenylalanine into stizolobinic acid, alpha-amino-6-carboxy-2-oxo-2H-pyran-3-propionic acid, and stizolobic acid, alpha-amino-6-carboxy-2-oxo-2H-pyran-4-propionic acid, in the pr... | Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo. It was demonstrated that an enzyme system(s) extracted from etiolated seedlings of S... | [
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PMID:9286 | Isolation and partial characterization of the cytochrome oxidase from Rhodopseudomonas palustris. | The cytochrome oxidase (EC 1.9.3.1) of Rhodopseudomonas palustris was extracted with Triton X-100 plus KCl, from the membrane fraction of cells grown aerobically in the dark. The solubilized enzyme was purified by (NH4)2SO4 precipitation and chromatography on DEAE-cellulose. The purification resulted in a 108-fold enri... | Isolation and partial characterization of the cytochrome oxidase from Rhodopseudomonas palustris. The cytochrome oxidase (EC 1.9.3.1) of Rhodopseudomonas palustris was extracted with Triton X-100 plus KCl, from the membrane fraction of cells grown aerobically in the dark. The solubilized enzyme was purified by (NH4)2SO... | [
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PMID:9287 | Distinct steps in the specific binding of tRNA to aminoacyl-tRNA synthetase. Temperature-jump studies on the serine-specific system from yeast and the tyrosine-specific system from Escherichia coli. | The kinetics of the interaction of tRNASer and seryl-tRNA synthetase from yeast as well as of tRNATyr and tyrosyl-tRNA synthetase from Escherichia coli have been investigated by temperature-jump experiments. It could be shown that complex formation proceeds in two distinct steps. This was demonstrated for both the firs... | Distinct steps in the specific binding of tRNA to aminoacyl-tRNA synthetase. Temperature-jump studies on the serine-specific system from yeast and the tyrosine-specific system from Escherichia coli. The kinetics of the interaction of tRNASer and seryl-tRNA synthetase from yeast as well as of tRNATyr and tyrosyl-tRNA sy... | [
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PMID:9288 | Mechanism of discrimination between cognate and non-cognate tRNAs by phenylalanyl-tRNA synthetase from yeast. | The interaction between phenylalanyl-tRNA synthetase from yeast and Escherichia coli and tRNAPhe (yeast), tRNASer (yeast), tRNA1Val (E. coli) has been investigated by ultracentrifugation analysis, fluorescence titrations and fast kinetic techniques. The fluorescence of the Y-base of tRNAPhe and the intrinsic fluorescen... | Mechanism of discrimination between cognate and non-cognate tRNAs by phenylalanyl-tRNA synthetase from yeast. The interaction between phenylalanyl-tRNA synthetase from yeast and Escherichia coli and tRNAPhe (yeast), tRNASer (yeast), tRNA1Val (E. coli) has been investigated by ultracentrifugation analysis, fluorescence ... | [
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PMID:9289 | Experimental infusion thrombophlebitis. Importance of the infusion rate. | The importance of the method of administration of acid glucose infusions for the venous inflammatory response has been investigated in two series of experimental trials. 60 ml of 5% glucose solution was administered into rabbit-ear veins in three ways: 1) continuously over 5 hours (slow infusion), 2) continuously over ... | Experimental infusion thrombophlebitis. Importance of the infusion rate. The importance of the method of administration of acid glucose infusions for the venous inflammatory response has been investigated in two series of experimental trials. 60 ml of 5% glucose solution was administered into rabbit-ear veins in three ... | [
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PMID:9290 | Experimental infusion thrombophlebitis. Importance of the pH of glucose solutions. | An experimental method is presented, which compares the tendency of different infusions to cause thrombophlebitis. It is based ona quantitative histological analysis of the inflammatory changes in the veins of rabbit ears after infusions under standardized conditions. By means of this method the inflammatory changes in... | Experimental infusion thrombophlebitis. Importance of the pH of glucose solutions. An experimental method is presented, which compares the tendency of different infusions to cause thrombophlebitis. It is based ona quantitative histological analysis of the inflammatory changes in the veins of rabbit ears after infusions... | [
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PMID:9291 | Cardiovascular response to exercise under increasing doses of chlorthalidone. | Five male subjects with essential hypertension received chlorthalidone at each of four dose levels (25, 50, 100, and 200 mg/day) for eight week periods each preceded by an eight week placebo period. Dosage order was randomized and double-blind. During the last week of each active and placebo period an upright bicycle e... | Cardiovascular response to exercise under increasing doses of chlorthalidone. Five male subjects with essential hypertension received chlorthalidone at each of four dose levels (25, 50, 100, and 200 mg/day) for eight week periods each preceded by an eight week placebo period. Dosage order was randomized and double-blin... | [
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PMID:9292 | Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension. I. Relationship between plasma concentration and adrenergic beta-receptor blockade. | Mean steady-state plasma concentrations of alprenolol were studied in relationship to the degree of beta-blockade, in sixteen patients receiving 600 mg daily in divided doses. Steady-state alprenolol concentrations were determined from the area under the plasma concentration-time curve during one eight-hour dosage inte... | Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension. I. Relationship between plasma concentration and adrenergic beta-receptor blockade. Mean steady-state plasma concentrations of alprenolol were studied in relationship to the degree of beta-blockade, in sixteen patients receiving 600 m... | [
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PMID:9293 | The cardiovascular effects of etilefrine. | Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1-8 mg etilefrine but begins to rise at higher dosage. Marked falls in pulse rate, cardiac output, stroke... | The cardiovascular effects of etilefrine. Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1-8 mg etilefrine but begins to rise at higher dosage. Marked f... | [
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PMID:9294 | In vitro stability of proscillaridin A. | In an in vitro study, proscillardin A was found to be rapidly inactivated at low pH. More than 50 per cent of its activity, measured by 86Rb assay, was lost after incubation for 15 minutes at pH 1 and 37 degrees C. Compared with proscillaridin, the rate of inactivation of digoxin was lower in these experiments. The rap... | In vitro stability of proscillaridin A. In an in vitro study, proscillardin A was found to be rapidly inactivated at low pH. More than 50 per cent of its activity, measured by 86Rb assay, was lost after incubation for 15 minutes at pH 1 and 37 degrees C. Compared with proscillaridin, the rate of inactivation of digoxin... | [
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PMID:9295 | Double-blind cross-over comparison of clenbuterol and salbutamol tablets in asthmatic out-patients. | A double-blind cross-over comparison of a new beta2-sympathomimetic bronchodilator, clenbuterol, with salbutamol and placebo has been made during a 24 day period of out-patient treatment of 19 adults with moderately severe asthma. Oral clenbuterol (10 mug 3 times a day) and salbutamol (4 mg 3 times a day) were equally ... | Double-blind cross-over comparison of clenbuterol and salbutamol tablets in asthmatic out-patients. A double-blind cross-over comparison of a new beta2-sympathomimetic bronchodilator, clenbuterol, with salbutamol and placebo has been made during a 24 day period of out-patient treatment of 19 adults with moderately seve... | [
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PMID:9296 | Effects of dixyrazine and methaqualone on the sleep pattern in normal man. | Whole night EEG and polygraphic recordings were made in ten young, healthy, male volunteers after dixyrazine (12.5 mg, 25 mg, 50 mg), methaqualone (250 mg) and Isonox (methaqualone 250 mg + etodroxizine 50 mg). A total of 156 recording nights (36 adaptation nights were not included in the analyses) were scored for diff... | Effects of dixyrazine and methaqualone on the sleep pattern in normal man. Whole night EEG and polygraphic recordings were made in ten young, healthy, male volunteers after dixyrazine (12.5 mg, 25 mg, 50 mg), methaqualone (250 mg) and Isonox (methaqualone 250 mg + etodroxizine 50 mg). A total of 156 recording nights (3... | [
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PMID:9297 | Evaluation of in vivo parameters of drug metabolizing enzyme activity in man after administration of clemastine, phenobarbital or placebo. | The 24 h urinary excretion of 6beta-hydroxycortisol and D-glucaric acid, the plasma half lives and total clearances of aminopyrine, and serum gamma-glutamyl-transpeptidase activity have been measured in nineteen healthy male volunteers. The study was done double blind and was conducted as a test of induction of microso... | Evaluation of in vivo parameters of drug metabolizing enzyme activity in man after administration of clemastine, phenobarbital or placebo. The 24 h urinary excretion of 6beta-hydroxycortisol and D-glucaric acid, the plasma half lives and total clearances of aminopyrine, and serum gamma-glutamyl-transpeptidase activity ... | [
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PMID:9298 | Long term treatment of moderate hypertension with penbutolol (Hoe 893d). I. Effects on blood pressure, pulse rate, catecholamines in blood and urine, plasma renin activity and urinary aldosterone under basal conditions and following exercise. | The effects of penbutolol (Hoe 893 d), a new non-selective beta-receptor blocking agent, were studied in 5 patients with moderate hypertension. Initially, it was shown that 2-4 mg given orally once or twice daily tended to lower blood pressure and pulse rate, both at rest and following submaximal work. In prolonged tri... | Long term treatment of moderate hypertension with penbutolol (Hoe 893d). I. Effects on blood pressure, pulse rate, catecholamines in blood and urine, plasma renin activity and urinary aldosterone under basal conditions and following exercise. The effects of penbutolol (Hoe 893 d), a new non-selective beta-receptor bloc... | [
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PMID:9299 | Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man. | A method has been developed for the quantitative determination of heptabarbital [5-(1-cyclohepten-1-yl)-5-ethylbarbituric acid] in human plasma after administration of single therapeutic doses of the drug. It involves a single extraction step followed by gas chromatography with alkali flame ionization detection, and th... | Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man. A method has been developed for the quantitative determination of heptabarbital [5-(1-cyclohepten-1-yl)-5-ethylbarbituric acid] in human plasma after administration of single therapeutic doses of th... | [
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PMID:9300 | The physiological disposition of etilefrine in man. | Pharmacokinetic and metabolic studies with 3H-etilefrine were performed to assess the importance of a first-pass effect on the pharmacodynamic action of this sympathomimetic amine. Identical amounts of 3H-activity, ca. 80% of the dose, were excreted in the urine after intravenous or oral administration, which indicates... | The physiological disposition of etilefrine in man. Pharmacokinetic and metabolic studies with 3H-etilefrine were performed to assess the importance of a first-pass effect on the pharmacodynamic action of this sympathomimetic amine. Identical amounts of 3H-activity, ca. 80% of the dose, were excreted in the urine after... | [
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PMID:9301 | Long term treatment of moderate hypertension with penbutolol (Hoe 893d). II. Effect on the response of plasma catecholamines and plasma renin activity to insulin-induced hypoglycemia. | The effect of insulin-induced hypoglycemia on the blood levels of catecholamines and renin activity has been studied in five patients with moderate hypertension before and after treatment for 3 - 8 months with penbutolol (PEN) 20 - 30 mg twice daily. Penbutolol caused no change in fasting blood glucose level. Insulin o... | Long term treatment of moderate hypertension with penbutolol (Hoe 893d). II. Effect on the response of plasma catecholamines and plasma renin activity to insulin-induced hypoglycemia. The effect of insulin-induced hypoglycemia on the blood levels of catecholamines and renin activity has been studied in five patients wi... | [
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PMID:9302 | Gastrointestinal absorption and metabolism of two 35S-labelled ampicillin esters. | Two ampicillin esters, 35S-pivampicillin and 35S-carampicillin and polyethylene glycol (nonabsorbable marker) were given orally to healthy subjects with gastrointestinal tubes. The cumulative absorption of radioactivity in both compounds (60-90%) was higher than (25-67%) previously found after administration of 35S-amp... | Gastrointestinal absorption and metabolism of two 35S-labelled ampicillin esters. Two ampicillin esters, 35S-pivampicillin and 35S-carampicillin and polyethylene glycol (nonabsorbable marker) were given orally to healthy subjects with gastrointestinal tubes. The cumulative absorption of radioactivity in both compounds ... | [
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PMID:9303 | Brain homovanillic acid: regional changes over time with antipsychotic drugs. | Acute administration of equivalent doses of either chlorpromazine, thioridazine, or clozapine, respectively, produced progressively smaller increases in brain homovanillic acid (HVA) in the rabbit; however, changes in HVA in three brain regions were of equal magnitude for a single dose of a given drug. Chronic administ... | Brain homovanillic acid: regional changes over time with antipsychotic drugs. Acute administration of equivalent doses of either chlorpromazine, thioridazine, or clozapine, respectively, produced progressively smaller increases in brain homovanillic acid (HVA) in the rabbit; however, changes in HVA in three brain regio... | [
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PMID:9309 | Hypoxia in fibroblast cultures. I. Changes in glucose consumption by 5 vol.-% oxygen concentration and reduced pH. | In secondary cultures of rat embryonic fibroblasts the glucose consumption and lactate concentration were comparatively investigated in 5 and 21 Vol.-% O2 environment at pH 6.6 and pH 7.4 (HEPES-buffer). The results were correlated with cell density. The following observations were made: 1. At pH 6.6 the rate of cell p... | Hypoxia in fibroblast cultures. I. Changes in glucose consumption by 5 vol.-% oxygen concentration and reduced pH. In secondary cultures of rat embryonic fibroblasts the glucose consumption and lactate concentration were comparatively investigated in 5 and 21 Vol.-% O2 environment at pH 6.6 and pH 7.4 (HEPES-buffer). T... | [
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PMID:9310 | Hypoxia in fibroblast cultures. 2. Influence of pH on the distribution pattern of acid mucopolysaccharides. | Secondary cultures of embryonic rat fibroblasts [NEUPERT et al., Exp. Path. 7, 19-28 (1972)] were cultured in 21% and 5% O2 concentration at pH 6.6 and 7.4 for 6 or 8 days. The acid mucopolysaccharides were isolated and fractionated by alcohol precipitation, papain digestion, CPC-precipitation and fractionation after t... | Hypoxia in fibroblast cultures. 2. Influence of pH on the distribution pattern of acid mucopolysaccharides. Secondary cultures of embryonic rat fibroblasts [NEUPERT et al., Exp. Path. 7, 19-28 (1972)] were cultured in 21% and 5% O2 concentration at pH 6.6 and 7.4 for 6 or 8 days. The acid mucopolysaccharides were isola... | [
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PMID:9311 | The extracellular protease from Pseudomonas fluorescens. | An extracellular protease has been purified from cultures of Pseudomonas fluorescens. It is a metalloenzyme with a molecular weight of 37,000 +/- 3,700, able to digest casein, hemoglobin and gelatine. | The extracellular protease from Pseudomonas fluorescens. An extracellular protease has been purified from cultures of Pseudomonas fluorescens. It is a metalloenzyme with a molecular weight of 37,000 +/- 3,700, able to digest casein, hemoglobin and gelatine. | [
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PMID:9312 | Anionic activation of human salivary amylase. | In all earlier studies on alpha-amylase, the influence of different ions were studied in phosphate buffer. The present report shows the effect of different ions individually with Tris and amino acid. Though it has been claimed recently that sodium ion is an activator of alpha-amylase, this study reconfirms that sodium ... | Anionic activation of human salivary amylase. In all earlier studies on alpha-amylase, the influence of different ions were studied in phosphate buffer. The present report shows the effect of different ions individually with Tris and amino acid. Though it has been claimed recently that sodium ion is an activator of alp... | [
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PMID:9313 | Effect of benzimidazole on nicotinamide adenine dinucleotide phosphate phosphomonoesterase activity in wheat leaves. | Nicotinamide adenine dinucleotide phosphate phosphomonoesterase was isolated and partially purified from wheat (Triticum aestivum L. var. Selkirk) leaves. The enzyme had KNADP value of 1.4 X 10(-4) M and a pH optimum of 5.9. In vitro activity of this enzyme was unaffected by precursors of NAD (nicotinamide and nicotini... | Effect of benzimidazole on nicotinamide adenine dinucleotide phosphate phosphomonoesterase activity in wheat leaves. Nicotinamide adenine dinucleotide phosphate phosphomonoesterase was isolated and partially purified from wheat (Triticum aestivum L. var. Selkirk) leaves. The enzyme had KNADP value of 1.4 X 10(-4) M and... | [
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PMID:9314 | Gastric mucus effusion elicited by oral copper compounds: potential anti-ulcer activity. | In rats, both Cu(I) and Cu(II) show an irritancy profile not shared with Cu degrees or Zn(II) or Ni(II). The gastric response to Cu(II), i.e. copius fluid and mucus secretion, can protect the stomach from the acute ulcerative effects of aspirin or physical stress administered subsequently. | Gastric mucus effusion elicited by oral copper compounds: potential anti-ulcer activity. In rats, both Cu(I) and Cu(II) show an irritancy profile not shared with Cu degrees or Zn(II) or Ni(II). The gastric response to Cu(II), i.e. copius fluid and mucus secretion, can protect the stomach from the acute ulcerative effec... | [
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PMID:9318 | The effect of ion-exchange column chromatography on separation of X and Y chromosome-bearing human spermatozoa. | Separation of X and Y chromosome-bearing spermatozoa has been attempted using ion-exchange column chromatography, with cation- and anion-exchange resins of low, intermediate, and high ionic strength. Examination of F-bodies on the Y chromosome of treated human sperm and progeny resulting from insemination of treated ra... | The effect of ion-exchange column chromatography on separation of X and Y chromosome-bearing human spermatozoa. Separation of X and Y chromosome-bearing spermatozoa has been attempted using ion-exchange column chromatography, with cation- and anion-exchange resins of low, intermediate, and high ionic strength. Examinat... | [
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PMID:9319 | Equality in survival of X and Y chromosome-bearing human spermatozoa. | Human X and Y chromosome-bearing spermatozoa survived equally well during washing and resuspension in buffers of pH 5.2 and 8.0 and during incubation in these buffers for 11 hours at 37 degrees C. This suggests that alteration of the ratio of living X- and Y-bearing spermatozoa by direct treatment is not an effective m... | Equality in survival of X and Y chromosome-bearing human spermatozoa. Human X and Y chromosome-bearing spermatozoa survived equally well during washing and resuspension in buffers of pH 5.2 and 8.0 and during incubation in these buffers for 11 hours at 37 degrees C. This suggests that alteration of the ratio of living ... | [
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PMID:9320 | Accumulation of nicotine in the uterine fluid of the six-day pregnant rabbit. | In 6-day pregnant New Zealand White rabbits dosed intravenously with 3H-nicotine, the 3H-activity in the uterine fluid was approximately 5 to 11 times greater than that in the plasma at the corresponding times; 3H-nicotine itself accounted for most of this radioactivity. Dichlorodiphenyltrichloroethane (DDT) also accum... | Accumulation of nicotine in the uterine fluid of the six-day pregnant rabbit. In 6-day pregnant New Zealand White rabbits dosed intravenously with 3H-nicotine, the 3H-activity in the uterine fluid was approximately 5 to 11 times greater than that in the plasma at the corresponding times; 3H-nicotine itself accounted fo... | [
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PMID:9322 | Oxygen transport impairment in diabetes. | Oxyhemoglobin dissociation curves (ODC) from zero to full saturation were developed from tests performed on whole blood from various groups of diabetic and nondiabetic healthy subjects. P50 at in-vivo pH was slightly but significantly lower than normal in ambulatory nonacidotic, uncomplicated juvenile diabetics (26.0 v... | Oxygen transport impairment in diabetes. Oxyhemoglobin dissociation curves (ODC) from zero to full saturation were developed from tests performed on whole blood from various groups of diabetic and nondiabetic healthy subjects. P50 at in-vivo pH was slightly but significantly lower than normal in ambulatory nonacidotic,... | [
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PMID:9323 | Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics. | The present findings of increased microvascular protein passage are compatible with the hypothesis that the organic, histologically demonstrated diabetic microangiopathy is a long-term effect of periods of increased extravasation of plasma proteins, with subsequent protein deposition in the microvascular wall, i.e., th... | Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics. The present findings of increased microvascular protein passage are compatible with the hypothesis that the organic, histologically demonstrated diabetic microangiopathy is a long-term effect of periods of increased extr... | [
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PMID:9324 | Muscle metabolism during rest and exercise: influence on the oxygen transport system of blood in normal and diabetic subjects. | The oxygen dissociation curve shifted less to the right in venous blood draining from muscle in eight insulin-deficient diabetics working at a constant submaximal workload than in seven normal controls (28.7 mm. Hg vs. 30.8 mm Hg; P less than 0.05). This diminution of the in-vivo Bohr effect at the muscle tissue level ... | Muscle metabolism during rest and exercise: influence on the oxygen transport system of blood in normal and diabetic subjects. The oxygen dissociation curve shifted less to the right in venous blood draining from muscle in eight insulin-deficient diabetics working at a constant submaximal workload than in seven normal ... | [
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PMID:9325 | Effect of duodenal acidification on gastric mucus and acid secretion in conscious cats. | In cats with gastric fistulae and Heidenhein pouches, the effect of acid entering the duodenum on secretion of acid, pepsin, and mucus from the Heidenhain pouch during maximal acid stimulation with pentagastrin or histamine, was studied. Duodenal acidification produced stimulation of pepsin and mucus secretion comparab... | Effect of duodenal acidification on gastric mucus and acid secretion in conscious cats. In cats with gastric fistulae and Heidenhein pouches, the effect of acid entering the duodenum on secretion of acid, pepsin, and mucus from the Heidenhain pouch during maximal acid stimulation with pentagastrin or histamine, was stu... | [
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PMID:9327 | Higher transpeptidation activity and broad acceptor specificity of gamma-glutamyltransferases of tumors. | The gamma-glutamyltransferase (EC 2.3.2.2) (=gamma-glutamyltranspeptidase, gamma-GTP) activity in hepatoma induced by 3'-methyl-4-(dimethylamino)azobenzene (3'-Me-DAB) was 120-fold higher than that of normal liver and high activity was also found in bovine hepatocellular carcinoma. gamma-GTPs from these malignant tissu... | Higher transpeptidation activity and broad acceptor specificity of gamma-glutamyltransferases of tumors. The gamma-glutamyltransferase (EC 2.3.2.2) (=gamma-glutamyltranspeptidase, gamma-GTP) activity in hepatoma induced by 3'-methyl-4-(dimethylamino)azobenzene (3'-Me-DAB) was 120-fold higher than that of normal liver a... | [
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PMID:9328 | Ion selective effects of salicylate on antral mucosa. | The effects of luminal salicylate, 5mM, were measured on rates of ion transport by isolated antral mucosa. At neutral luminal pH, salicylate increases Na and decreases Cl permeability. Salicylate does not alter net Na transport but decreases net Cl secretion. At luminal pH 4, the effects of salicylate can be arbitraril... | Ion selective effects of salicylate on antral mucosa. The effects of luminal salicylate, 5mM, were measured on rates of ion transport by isolated antral mucosa. At neutral luminal pH, salicylate increases Na and decreases Cl permeability. Salicylate does not alter net Na transport but decreases net Cl secretion. At lum... | [
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PMID:9329 | Mechanism of prevention of aspirin-induced gastric lesions by bile duct legation in the rat. | Gastric reflux of bile has been reported to be essential for the production of acute gastric mucosal lesions by intragastric aspirin in the rat. The purpose of the present study was to determine whether bile duct legation of pylorus ligation in the rat inhibits asprin-induced gastric lesions, and, if so, what the prote... | Mechanism of prevention of aspirin-induced gastric lesions by bile duct legation in the rat. Gastric reflux of bile has been reported to be essential for the production of acute gastric mucosal lesions by intragastric aspirin in the rat. The purpose of the present study was to determine whether bile duct legation of py... | [
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PMID:9330 | Gastric mucosal lesions produced by intravenous infusion of aspirin in cats. | Aspirin was given by continuous intravenous infusion to 35 intact cats for 7 days in doses ranging from 25 to 200 mg kg-1 day-1. Gastric mucosal lesions occurred in 50 to 70% of the animals in the various dosage groups, including deep ulcers in 20%. All of the ulcers were in antral mucosa near its border with oxyntic m... | Gastric mucosal lesions produced by intravenous infusion of aspirin in cats. Aspirin was given by continuous intravenous infusion to 35 intact cats for 7 days in doses ranging from 25 to 200 mg kg-1 day-1. Gastric mucosal lesions occurred in 50 to 70% of the animals in the various dosage groups, including deep ulcers i... | [
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PMID:9331 | Influence of acid secretory state on the gastric mucosal tolerance to back diffusion of H+. | The effect of back diffusion of H+ PON THE POTENTIAL DIFFERence (PD), electrical resistance (R), and short circuit current (Isc) of spontaneously secreting and burimamide-inhibited amphibian gastric mucosae were studied in vitro. When back diffusion of H+ was induced by the passage of an electrical current of 510 mua p... | Influence of acid secretory state on the gastric mucosal tolerance to back diffusion of H+. The effect of back diffusion of H+ PON THE POTENTIAL DIFFERence (PD), electrical resistance (R), and short circuit current (Isc) of spontaneously secreting and burimamide-inhibited amphibian gastric mucosae were studied in vitro... | [
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PMID:9332 | gamma-glutamyl transpeptidase of rat intestine: localization and possible role in amino acid transport. | gamma-Glutamyl transpeptidase (gamma-GT), an enzyme possibly involved in amino acid transport, was investigated in rat small intestine using the synthetic substrate L-gamma-glutamyl-p-nitroanilide. Enzyme localization and characteristics were correlated with features of amino acid uptake. gamma-GT activity copurified w... | gamma-glutamyl transpeptidase of rat intestine: localization and possible role in amino acid transport. gamma-Glutamyl transpeptidase (gamma-GT), an enzyme possibly involved in amino acid transport, was investigated in rat small intestine using the synthetic substrate L-gamma-glutamyl-p-nitroanilide. Enzyme localizatio... | [
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PMID:9333 | Association of inflammatory bowel disease and large vascular lesions. | A case of inflammatory bowel disease with associated multiple large vessel vascular lesions similar to that seen in Takayasu's arteritis is described in a 15-year-old female. It is suggested that this type of vascular lesion may represent another rare systemic manifestation of inflammatory bowel disease. | Association of inflammatory bowel disease and large vascular lesions. A case of inflammatory bowel disease with associated multiple large vessel vascular lesions similar to that seen in Takayasu's arteritis is described in a 15-year-old female. It is suggested that this type of vascular lesion may represent another rar... | [
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PMID:9338 | Presence or absence of inhibitors of crystal growth in bile. 1. Effect of bile on the formation of calcium phosphate, a constituent of gallstones. | When calcium and phosphate ions were mixed so that their final concentration was 4 mmol/1 and the pH was kept at 7-0, an amorphous precipitate immediately formed and this changed into crystalline material with an apatite-like structure after a period of time. The formation of either or both types of precipitate could b... | Presence or absence of inhibitors of crystal growth in bile. 1. Effect of bile on the formation of calcium phosphate, a constituent of gallstones. When calcium and phosphate ions were mixed so that their final concentration was 4 mmol/1 and the pH was kept at 7-0, an amorphous precipitate immediately formed and this ch... | [
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PMID:9340 | [Interaction of dl-mandelamidine (Olimidine) with some antihypertensive drugs expressed in the blood pressure of conscious rats]. | Hypotensive effect of dl-Mandelamidine (Olmidine, MA) in combination with some established antihypertensive drugs was studied in conscious normotensive rats. The mean blood pressure and heart rate were measured by means of a pressure transducer via a polyethylene tube inserted into the abdominal aorta of rat according ... | [Interaction of dl-mandelamidine (Olimidine) with some antihypertensive drugs expressed in the blood pressure of conscious rats]. Hypotensive effect of dl-Mandelamidine (Olmidine, MA) in combination with some established antihypertensive drugs was studied in conscious normotensive rats. The mean blood pressure and hear... | [
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PMID:9341 | [Metabolic fate of carteolol hydrochloride (OPC-1085), a new beta-adrenergic agent. (3) Autoradiographic total body distribution studies in mice]. | Distribution of a new beta-adrenergic blocking agent, 3H-carteolol in mice was studied by whole body autoradiography. The distribution of radioactivity was observed in all organs except the eyes and brain, with particularly high specific activities in the kidneys, liver, gall bladder and content in the intestines withi... | [Metabolic fate of carteolol hydrochloride (OPC-1085), a new beta-adrenergic agent. (3) Autoradiographic total body distribution studies in mice]. Distribution of a new beta-adrenergic blocking agent, 3H-carteolol in mice was studied by whole body autoradiography. The distribution of radioactivity was observed in all o... | [
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PMID:9342 | Biochemical basis of an animal model of depressive illness--a preliminary report--. | Biochemical analyses of brain samples of an Animal Model of Depression indicate the state of motionlessness observed in response to a conditioned stimulus was due to an excess in functional activity of serotonin. An excess functional activity of serotonin may be directly responsible for human depressive illness. This c... | Biochemical basis of an animal model of depressive illness--a preliminary report--. Biochemical analyses of brain samples of an Animal Model of Depression indicate the state of motionlessness observed in response to a conditioned stimulus was due to an excess in functional activity of serotonin. An excess functional ac... | [
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PMID:9344 | [Current resistence situation in a surgical and urological department]. | Spectrum and sensitivity of bacteria were studied at the Surgical (534 positive wound smears) and the Urological Clinics (7879 urine specimens). Krankenhaus Nordwest, Frankfurt/M., during the period of 1969-1971 and in 1973. The most common organisms identified in wound smears were E. coli, followed by Staph. areus, Ae... | [Current resistence situation in a surgical and urological department]. Spectrum and sensitivity of bacteria were studied at the Surgical (534 positive wound smears) and the Urological Clinics (7879 urine specimens). Krankenhaus Nordwest, Frankfurt/M., during the period of 1969-1971 and in 1973. The most common organis... | [
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PMID:9345 | [Newer aspects in the therapy of angina pectoris]. | Progress in coronary surgery has led to new aspects in the treatment of angina pectoris. According to the coronar-angiographic findings, which make an exact identification of the coronary heart disease possible, and according to the ventricular function a therapeutic strategy can be determined today with adequate safet... | [Newer aspects in the therapy of angina pectoris]. Progress in coronary surgery has led to new aspects in the treatment of angina pectoris. According to the coronar-angiographic findings, which make an exact identification of the coronary heart disease possible, and according to the ventricular function a therapeutic s... | [
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PMID:9346 | [Inflammatory intestinal diseases: ulcerative colitis and Crohn's disease. Early diagnosis and treatment]. | Early rather characteristic symptoms are found in ulcerative colitis as well as in Crohn's disease. In these patients, but also in an advanced stage, differential diagnosis between these two disorders is possible by means of endoscopic techniques and guided biopsy. In a high percentage of patients with ulcerative colit... | [Inflammatory intestinal diseases: ulcerative colitis and Crohn's disease. Early diagnosis and treatment]. Early rather characteristic symptoms are found in ulcerative colitis as well as in Crohn's disease. In these patients, but also in an advanced stage, differential diagnosis between these two disorders is possible ... | [
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PMID:9347 | [Polygraphic recording of sleep under the influence of Plantival plus]. | 10 patients with moderate non-psychotic sleep disturbances were investigated polygraphically for a total of 14 nights each. These 14 nights were subdivided into 4 test series: Placebo was given during the first, Plantival plus during the second and third and placebo again during the fourth series. The results showed th... | [Polygraphic recording of sleep under the influence of Plantival plus]. 10 patients with moderate non-psychotic sleep disturbances were investigated polygraphically for a total of 14 nights each. These 14 nights were subdivided into 4 test series: Placebo was given during the first, Plantival plus during the second and... | [
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PMID:9348 | Poly(adenosine diphosphate ribose) is covalently linked to nuclear proteins by two types of bonds. | (ADP-ribose)n residues formed by short-term incubation of adult rat liver and Ehrlich carcinoma nuclei with labeled NAD were analyzed by Cs2SO4/guanidinium chloride/urea density gradient centrifugation. Comparison with samples in which the protein had been completely digested revealed that most, or probably all, acid-i... | Poly(adenosine diphosphate ribose) is covalently linked to nuclear proteins by two types of bonds. (ADP-ribose)n residues formed by short-term incubation of adult rat liver and Ehrlich carcinoma nuclei with labeled NAD were analyzed by Cs2SO4/guanidinium chloride/urea density gradient centrifugation. Comparison with sa... | [
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PMID:9349 | On the mechanism and some properties of vinylacetyl-CoA delta-isomerase of Clostridium kluyveri. | Vinylacetyl-CoA delta-isomerase from Clostridium kluyveri grown on ethanol/acetate was purified 32-fold. The enzyme is rather labile. All experiments were conducted with the substrate analog thioester of vinylacetic acid and N-acetylchysteamine (vinylacetyl-SEtNAc (1 f)). 3-Butinoyl-SEtNAc is a strong inhibitor of the ... | On the mechanism and some properties of vinylacetyl-CoA delta-isomerase of Clostridium kluyveri. Vinylacetyl-CoA delta-isomerase from Clostridium kluyveri grown on ethanol/acetate was purified 32-fold. The enzyme is rather labile. All experiments were conducted with the substrate analog thioester of vinylacetic acid an... | [
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PMID:9350 | A kallikrein-specific inhibitor in rat kidney tubules. | A kallikrein inhibitor was found in tubules of the rat kidney and purified by chromatography on Sephadex G-100. The molecular weight of the inhibitor, estimated by gel filtration and dodecylsulfate electrophoresis, is about 4700. It inhibits the following kallikreins: porcine submanidbular and pancreatic kallikrein, ra... | A kallikrein-specific inhibitor in rat kidney tubules. A kallikrein inhibitor was found in tubules of the rat kidney and purified by chromatography on Sephadex G-100. The molecular weight of the inhibitor, estimated by gel filtration and dodecylsulfate electrophoresis, is about 4700. It inhibits the following kallikrei... | [
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PMID:9351 | [Preparation and some properties of immobilized trypsin from the crayfish Cambarus affinis Say (author's transl)]. | The anionic tryptic enzyme from the crayfish (crayfish trypsin) was adsorbed to DEAE-Sephadex A-50 and covalently coupled to BrCN-activated Sepharose 4B and porous glass loaded with isothiocyanate propyl groups (ITC-glass). The relative activities against p-tosylarginine methyl ester (TosArgOMe) were found to be 30 to ... | [Preparation and some properties of immobilized trypsin from the crayfish Cambarus affinis Say (author's transl)]. The anionic tryptic enzyme from the crayfish (crayfish trypsin) was adsorbed to DEAE-Sephadex A-50 and covalently coupled to BrCN-activated Sepharose 4B and porous glass loaded with isothiocyanate propyl g... | [
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PMID:9352 | Identity of kynurenine: pyruvate aminotransferase with histidine: pyruvate aminotransferase. | Kynurenine pyruvate aminotransferase was purified from rat kidney. The purified enzyme had an isoelectric point of pH 5.2 and a pH optimum of 9.3. The enzyme was active with pyruvate as amino acceptor but not with 2-oxoglutarate, and utilized various aromatic amino acids as amino donors. L-Amino acids were effective in... | Identity of kynurenine: pyruvate aminotransferase with histidine: pyruvate aminotransferase. Kynurenine pyruvate aminotransferase was purified from rat kidney. The purified enzyme had an isoelectric point of pH 5.2 and a pH optimum of 9.3. The enzyme was active with pyruvate as amino acceptor but not with 2-oxoglutarat... | [
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PMID:9353 | Studies on the proteinase-A inhibitor I3A from yeast. | The purification and some properties of the two inhibitors I2A and I3A of proteinase A from yeast have previously been described [Saheki et al, (1974) Eur. J. Biochem. 47, 325]. An improved method for the preparation of I3A which is less time-consuming and leads to higher yields is presented. Based on amino acid analys... | Studies on the proteinase-A inhibitor I3A from yeast. The purification and some properties of the two inhibitors I2A and I3A of proteinase A from yeast have previously been described [Saheki et al, (1974) Eur. J. Biochem. 47, 325]. An improved method for the preparation of I3A which is less time-consuming and leads to ... | [
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... |
PMID:9359 | Antigenicity of type-specific pneumococcal polysaccharides in rats. | Hemagglutinating antibody responses of Lewis-Wistar and Sprague-Dawley rats to graded doses of type-specific pneumococcal polysaccharide were measured. Rats given a small dose (0.2 to 50 mug)of type 1 or 8 polysaccharide intraperitoneally developed type-specific hemagglutinating antibody. Rats given larger doses of pol... | Antigenicity of type-specific pneumococcal polysaccharides in rats. Hemagglutinating antibody responses of Lewis-Wistar and Sprague-Dawley rats to graded doses of type-specific pneumococcal polysaccharide were measured. Rats given a small dose (0.2 to 50 mug)of type 1 or 8 polysaccharide intraperitoneally developed typ... | [
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0.01... |
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