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PMID:9555 | Interactions of phospholipase D with 1,2 diacyl-sn-glycerol-3-phosphorylcholine, dodecylsulfate, and Ca2+. | Some properties of the pure, soluble phospholipase D (phosphatidycholine phosphatido hydrolase, EC 3.1.4.4) interactions with phosphatidyl choline (1,2 diacyl-sn-glycerol-3-phosphoryl choline) in a system also containing dodecylsulfate and Ca2+ ions were studied. Concentrations of Ca2+ greater than 50 mM were necessary... | Interactions of phospholipase D with 1,2 diacyl-sn-glycerol-3-phosphorylcholine, dodecylsulfate, and Ca2+. Some properties of the pure, soluble phospholipase D (phosphatidycholine phosphatido hydrolase, EC 3.1.4.4) interactions with phosphatidyl choline (1,2 diacyl-sn-glycerol-3-phosphoryl choline) in a system also con... | [
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PMID:9556 | Studies on drug-induced lipidosis: VII. Effects of bis-beta-diethyl-aminoethylether of hexestrol, chloroquine, homochlorocyclizine, prenylamine, and diazacholesterol on the lipid composition of rat liver and kidney. | 4,4'-Bis (beta-diethylaminoethoxy)-alpha, beta-diethyldiphenylethane (DH), which had been shown to induce a type of lipidosis resembling Niemann-Pick disease, was given to rats at a dose of 20, 50, 100, and 150 mg/kg body weight per day for 1 or 2 weeks. An enlargement of the liver with marked increases in free cholest... | Studies on drug-induced lipidosis: VII. Effects of bis-beta-diethyl-aminoethylether of hexestrol, chloroquine, homochlorocyclizine, prenylamine, and diazacholesterol on the lipid composition of rat liver and kidney. 4,4'-Bis (beta-diethylaminoethoxy)-alpha, beta-diethyldiphenylethane (DH), which had been shown to induc... | [
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PMID:9559 | Role of the parietal cell in gastric damage induced by aspirin and related drugs: implications for safer therapy. | The proton-secreting parietal cell is shown, from recent evidence, to be the principal focus for the actions of aspirin (and related drugs) in damaging the gastric mucosa. It is suggested that the selective damage to the parietal cells is due to the ph gradient favouring a high rate of aspirin uptake and subsequent ent... | Role of the parietal cell in gastric damage induced by aspirin and related drugs: implications for safer therapy. The proton-secreting parietal cell is shown, from recent evidence, to be the principal focus for the actions of aspirin (and related drugs) in damaging the gastric mucosa. It is suggested that the selective... | [
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PMID:9558 | Schizophrenic psychology, associative learning and the role of forebrain dopamine. | It is suggested that schizophrenic thinking can be explained as a lowering of levels of significance for acceptance of conclusions based on inductive logic. The formal similarity between inductive logic and operant, or classical conditioning is pointed out. It is thus possible to explain the therapeutic effects of neur... | Schizophrenic psychology, associative learning and the role of forebrain dopamine. It is suggested that schizophrenic thinking can be explained as a lowering of levels of significance for acceptance of conclusions based on inductive logic. The formal similarity between inductive logic and operant, or classical conditio... | [
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PMID:9581 | Two weeks' treatment with chlorpromazine, thioridazine, sulpiride, or bromazepam: actions and interactions with alcohol on psychomotor skills related to driving. | Subacute effects of C, T, S, or B, alone or in combination with A, were tested against P in two double-blind crossover trials with 37 healthy students. The drugs were given in capsules t.i.d. for 2 weeks each and the psychomotor performance (choice reaction, coordination, attention) was measured on the 7th and 14th day... | Two weeks' treatment with chlorpromazine, thioridazine, sulpiride, or bromazepam: actions and interactions with alcohol on psychomotor skills related to driving. Subacute effects of C, T, S, or B, alone or in combination with A, were tested against P in two double-blind crossover trials with 37 healthy students. The dr... | [
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PMID:9583 | [Longterm therapy of angina pectoris patients with a new beta-receptor blocker (author's transl)]. | The beta-receptor blocker Timolol was investigated for 28 weeks in a double blind trial and then for up to 100 weeks in an open trial in patients with angina pectoris. In both phases of the investigation. Timolol caused a quite marked regression in the frequency of attacks and in the pulse rate at rest. The evaluation ... | [Longterm therapy of angina pectoris patients with a new beta-receptor blocker (author's transl)]. The beta-receptor blocker Timolol was investigated for 28 weeks in a double blind trial and then for up to 100 weeks in an open trial in patients with angina pectoris. In both phases of the investigation. Timolol caused a... | [
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PMID:9584 | [Angina pectoris. Results of investigations to date (author's transl)]. | Among the most important coronary risk factors are a diet rich in saturated fatty acids, cholesterol and calories, hypercholesterolemia, high blood pressure and excessive smoking. The typical pain can be elicited by putting a strain on the patient, e.g. climbing stairs. The disappearance of the pain after treatment wit... | [Angina pectoris. Results of investigations to date (author's transl)]. Among the most important coronary risk factors are a diet rich in saturated fatty acids, cholesterol and calories, hypercholesterolemia, high blood pressure and excessive smoking. The typical pain can be elicited by putting a strain on the patient,... | [
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PMID:9593 | [Self cleaning of natural waters]. | The planting of the waters left the question open as to whether the necessary expenditure of work is really worthwhile and should be encouraged. The investigations reported here with higher and particularly emersed plants, show what an astonishing influence the higher plants exert on organic and inorganic matter, on pH... | [Self cleaning of natural waters]. The planting of the waters left the question open as to whether the necessary expenditure of work is really worthwhile and should be encouraged. The investigations reported here with higher and particularly emersed plants, show what an astonishing influence the higher plants exert on ... | [
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PMID:9594 | Lichens as indicators of air pollution. | Field and laboratory studies have demonstrated that lichens are extremely sensitive to sulfur dioxide and that lichens are fairly sensitive to hydrogen fluoride and heavy metals. Further studies are necessary to assess lichens' relative sensitivity to oxidant air pollutants. | Lichens as indicators of air pollution. Field and laboratory studies have demonstrated that lichens are extremely sensitive to sulfur dioxide and that lichens are fairly sensitive to hydrogen fluoride and heavy metals. Further studies are necessary to assess lichens' relative sensitivity to oxidant air pollutants. | [
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PMID:9595 | Molecular sensory physiology of Euglena. | After a short description of the motile physiology of Euglena gracilis the responses to light stimulation are analyzed and a new nomenclature is proposed concerning flagellar motility variations. A discussion follows about the characteristics of the photoreceptive system of Euglena and about the flavinic nature of its ... | Molecular sensory physiology of Euglena. After a short description of the motile physiology of Euglena gracilis the responses to light stimulation are analyzed and a new nomenclature is proposed concerning flagellar motility variations. A discussion follows about the characteristics of the photoreceptive system of Eugl... | [
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PMID:9597 | [Apudomas]. | Apudomas, i.e. tumours deriving from apud system cells, comprise already known forms located in widely different organs at considerable distances one from the other. They present great cytochemical, biochemical and ultrastructural similarities and possess a common derivation in the neuroectodermal cells of the neural c... | [Apudomas]. Apudomas, i.e. tumours deriving from apud system cells, comprise already known forms located in widely different organs at considerable distances one from the other. They present great cytochemical, biochemical and ultrastructural similarities and possess a common derivation in the neuroectodermal cells of ... | [
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PMID:9598 | [Critical observations on changes in gamma-glutamyl-transpepdidase in hepatopathies]. | The behaviour of gamma-glutamyl transpeptidase was compared with other serum enzyme activities and functional parameters in a carefully selected and relatively extensive series of patients with liver disease, including alcoholics, in an investigation of the underlying pathogenesis and its clinical expression. Reference... | [Critical observations on changes in gamma-glutamyl-transpepdidase in hepatopathies]. The behaviour of gamma-glutamyl transpeptidase was compared with other serum enzyme activities and functional parameters in a carefully selected and relatively extensive series of patients with liver disease, including alcoholics, in ... | [
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PMID:9599 | [Changes in partial pressures of gases and of pH in the arterial blood of hypocapnic and hypercapnic subjects subjected to oxygen therapy]. | The behaviour of partial tensions of respiratory gases and pH in the arterial blood was evaluated in anoxiaemic and hypercapnic (1st group) and hypo-eucapnic (IInd group) subjects undergoing oxygen therapy. The following phenomena were observed: 1) normalization in paO2 values in both groups; 2) statistically significa... | [Changes in partial pressures of gases and of pH in the arterial blood of hypocapnic and hypercapnic subjects subjected to oxygen therapy]. The behaviour of partial tensions of respiratory gases and pH in the arterial blood was evaluated in anoxiaemic and hypercapnic (1st group) and hypo-eucapnic (IInd group) subjects ... | [
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PMID:9600 | [Changes in acid-base equilibrium of the arterial blood in hypoxemic-eucapnic subjects subjected to oxygen therapy with and without an antiphosphodiesterase drug]. | The behaviour of the partial tensions of respiratory gases and the main parameters of acid base balance in hypoxaemic and eucapnic chronic bronchopneumopathics undergoing oxygen therapy has been assessed. The patiests were subdivided into two groups, the first consisting of subjects undergoing oxygen therapy alone, the... | [Changes in acid-base equilibrium of the arterial blood in hypoxemic-eucapnic subjects subjected to oxygen therapy with and without an antiphosphodiesterase drug]. The behaviour of the partial tensions of respiratory gases and the main parameters of acid base balance in hypoxaemic and eucapnic chronic bronchopneumopath... | [
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PMID:9601 | [Gasometric changes and acid-base equilibrium of venous blood oxygenated in vitro and incubated with or without a phosphodiesterase inhibitor]. | Changes in partial tension of the respiratory gases and in acid-base balance were studied in venous blood subjected to oxygenation, with or without incubation with theophylline. The following modifications were noted: 1) increased pO2; 2) decreased CO2 due to true wash-out caused by tonometry in oxygen; 3)decreased hyd... | [Gasometric changes and acid-base equilibrium of venous blood oxygenated in vitro and incubated with or without a phosphodiesterase inhibitor]. Changes in partial tension of the respiratory gases and in acid-base balance were studied in venous blood subjected to oxygenation, with or without incubation with theophylline... | [
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PMID:9602 | [Acid-base equilibrium of the arterial blood of subjects with grave hypercapnia subjected to mechanical ventilation with the iron lung (concerning 2 cases of post-hypercapnic alkalosis)]. | Two cases of severe chronic respiratory insufficiency in severely acute phase with disturbances in acid base balance characterized by serious gaseous acidosis are reported. Therapy was based essentially on controlled ventilotherapy using an iron lung and considerable improvements were achieved clinically with practical... | [Acid-base equilibrium of the arterial blood of subjects with grave hypercapnia subjected to mechanical ventilation with the iron lung (concerning 2 cases of post-hypercapnic alkalosis)]. Two cases of severe chronic respiratory insufficiency in severely acute phase with disturbances in acid base balance characterized b... | [
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PMID:9604 | Measurement of pituitary hormones: clinical applications. 5. Prolactin. | A sensitive and specific assay for human prolactin has been developed using human prolactin and antiserum distributed by the United States National Pituitary Agency. Plasma prolactin concentrations in control subjects ranged from 0-20 ng/ml. No sex difference in prolactin concentration was observed. A brisk increase in... | Measurement of pituitary hormones: clinical applications. 5. Prolactin. A sensitive and specific assay for human prolactin has been developed using human prolactin and antiserum distributed by the United States National Pituitary Agency. Plasma prolactin concentrations in control subjects ranged from 0-20 ng/ml. No sex... | [
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PMID:9605 | Correlation of fetal heart rate patterns and fetal pH with neonatal outcome. | Fetal monitoring data in 200 consecutive cases was evaluated in the second hour prior to delivery to determine how neonatal outcome could be most accurately predicted. It was found that the correlation between ominous fetal heart rate-uterine contraction (FHR-UC) patterns and a depressed Apgar score at 1 minute was, at... | Correlation of fetal heart rate patterns and fetal pH with neonatal outcome. Fetal monitoring data in 200 consecutive cases was evaluated in the second hour prior to delivery to determine how neonatal outcome could be most accurately predicted. It was found that the correlation between ominous fetal heart rate-uterine ... | [
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PMID:9614 | The detection of toxin production by Corynebacterium diphtheriae in diagnostic laboratories. | In vitro tests for assessing the toxigenicity of strains of C. diphtheriae using the original agar plate precipitin method of Elek are unreliable. At high concentrations of antitoxin (500-1000 U/ml) multiple non-specific precipitin lines occur making interpretation difficult. Increased specificity was obtained by dilut... | The detection of toxin production by Corynebacterium diphtheriae in diagnostic laboratories. In vitro tests for assessing the toxigenicity of strains of C. diphtheriae using the original agar plate precipitin method of Elek are unreliable. At high concentrations of antitoxin (500-1000 U/ml) multiple non-specific precip... | [
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PMID:9619 | Defective polymorphonuclear leukocyte chemotaxis and bactericidal capacity in a boy with recurrent pyogenic infections. | A 13-year-old boy with a history of recurrent pyogenic infections had abnormalities of polymorphonuclear leukocyte (PMN) function which probably accounted for his susceptibility to infection. PMN phagocytosis and nitroblue tetrazolium dye reduction were normal but glucose 14C oxidation was abnormally increased in resti... | Defective polymorphonuclear leukocyte chemotaxis and bactericidal capacity in a boy with recurrent pyogenic infections. A 13-year-old boy with a history of recurrent pyogenic infections had abnormalities of polymorphonuclear leukocyte (PMN) function which probably accounted for his susceptibility to infection. PMN phag... | [
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PMID:9620 | Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acid. | Poly 2'-azido-2'-deoxyadenylic acid (Poly Az) was synthesized from 2'-azido-2'-deoxyadenosine diphosphate by polynucleotide phosphorylase. Poly (Az) has U.V. absorption properties similar to poly (A) and hypochromicity of 40% at 0.1 M Na+ and neutrality. CD curve also resembled to that of poly (A), but has smaller elli... | Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acid. Poly 2'-azido-2'-deoxyadenylic acid (Poly Az) was synthesized from 2'-azido-2'-deoxyadenosine diphosphate by polynucleotide phosphorylase. Poly (Az) has U.V. absorption properties similar to poly (A) and hypochromicity of 40% at 0.1 M... | [
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PMID:9621 | Properties of DNA ligase from uninfected and virus-infected HeLa cells. | HeLa cells contain a high M.W. form of DNA ligase which can be completely converted to a low M.W. form. Stokes radius, frictional ratio, sedimentation coefficient, molecular weight, pH dependence, and heat inactivation rate of the two forms have been studied. The major properties of the two forms of DNA ligase in HeLa ... | Properties of DNA ligase from uninfected and virus-infected HeLa cells. HeLa cells contain a high M.W. form of DNA ligase which can be completely converted to a low M.W. form. Stokes radius, frictional ratio, sedimentation coefficient, molecular weight, pH dependence, and heat inactivation rate of the two forms have be... | [
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PMID:9622 | Histones bind more tightly to bromodeoxyuridine-substituted DNA than to normal DNA. | Using a membrane filter assay, we have obtained results from both kinetic and competition experiments indicating that histones bind more strongly to bromodeoxyuridine-substituted DNA than to normal DNA. At 37 degrees C in our standard buffer of 0.2 M ionic strength, the rate of dissociation of histones H1, H2, and h4 f... | Histones bind more tightly to bromodeoxyuridine-substituted DNA than to normal DNA. Using a membrane filter assay, we have obtained results from both kinetic and competition experiments indicating that histones bind more strongly to bromodeoxyuridine-substituted DNA than to normal DNA. At 37 degrees C in our standard b... | [
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PMID:9623 | The reaction between thiols and 8-azidoadenosine derivatives. | Thiols react at room temperature in dilute solution with 8-azidoadenosine and its nucleotides to give the corresponding 8-aminoadenosine derivatives. The reaction which takes place in the dark is base-catalysed and is particularly rapid when dithiols, e.g. dithiothreitol are used. | The reaction between thiols and 8-azidoadenosine derivatives. Thiols react at room temperature in dilute solution with 8-azidoadenosine and its nucleotides to give the corresponding 8-aminoadenosine derivatives. The reaction which takes place in the dark is base-catalysed and is particularly rapid when dithiols, e.g. d... | [
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PMID:9624 | Novikoff hepatoma deoxyribonucleic acid polymerase. Sensitivity of the beta-polymerase to sulfhydryl blocking agents. | Unlike other beta-class eukaryotic DNA polymerases, the enzyme purified from the Novikoff hepatoma is inhibited by both sulfhydryl blocking agents N-ethylmaleimide (NEM) and p-hydroxymercuribenzoate (pHMB). The degree of sensitivity varies depending on the enzyme purity, pH of the reaction, and the presence of sulfhydr... | Novikoff hepatoma deoxyribonucleic acid polymerase. Sensitivity of the beta-polymerase to sulfhydryl blocking agents. Unlike other beta-class eukaryotic DNA polymerases, the enzyme purified from the Novikoff hepatoma is inhibited by both sulfhydryl blocking agents N-ethylmaleimide (NEM) and p-hydroxymercuribenzoate (pH... | [
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PMID:9626 | The relationship between beta-blockade, hyporeninaemic and hypotensive effect of two beta-blocking agents. | In two consecutive series of hypertensive patients the hypotensive effect, the hyporeninaemic effect and the blockade of cardiac beta-receptors was studied using weekly increasing doses of propranolol or atenolol. With both beta-blockers, cardiac blockade and hypotensive effect increased in a parallel fashion when the ... | The relationship between beta-blockade, hyporeninaemic and hypotensive effect of two beta-blocking agents. In two consecutive series of hypertensive patients the hypotensive effect, the hyporeninaemic effect and the blockade of cardiac beta-receptors was studied using weekly increasing doses of propranolol or atenolol.... | [
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PMID:9627 | Ahlquist and the development of beta-adrenoceptor antagonists. | The power and fecundity of Ahlquist's original concept of alpha- and beta-receptors can now be seen in dramatic contrast to the obfuscation and sterility of the then contemporary theory of two "sympathins". But when his famous paper appeared in 1948, pharmacologists apparently were not ready for the new idea. Receptor ... | Ahlquist and the development of beta-adrenoceptor antagonists. The power and fecundity of Ahlquist's original concept of alpha- and beta-receptors can now be seen in dramatic contrast to the obfuscation and sterility of the then contemporary theory of two "sympathins". But when his famous paper appeared in 1948, pharma... | [
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PMID:9628 | The properties of beta-adrenoceptor antagonists. | After the clinical studies with pronethalol and propranolol confirmed Black's hypothesis that drugs which block beta-adrenoceptors were of value in the treatment of patients with angina pectoris and cardiac arrhythmias, other compounds have been described which block beta-adrenoceptors. Detailed pharmacological studies... | The properties of beta-adrenoceptor antagonists. After the clinical studies with pronethalol and propranolol confirmed Black's hypothesis that drugs which block beta-adrenoceptors were of value in the treatment of patients with angina pectoris and cardiac arrhythmias, other compounds have been described which block bet... | [
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PMID:9629 | Beta-blockade and mechanisms of disease. | In this review an attempt has been made to define the contribution of beta-antagonists to out understanding of the mechanisms of disease. It is concluded that beta-antagonists, and propranolol in particular, have clarified mechanisms in angina pectoris, cardiac arrhythmias and some aspects of essential hypertension as ... | Beta-blockade and mechanisms of disease. In this review an attempt has been made to define the contribution of beta-antagonists to out understanding of the mechanisms of disease. It is concluded that beta-antagonists, and propranolol in particular, have clarified mechanisms in angina pectoris, cardiac arrhythmias and s... | [
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PMID:9630 | Mechanism of action of beta-blocking drugs in angina pectoris: a review. | The effect of beta-blockers in improving exercise tolerance in angina pectoris can be accounted for by the reduction in heart rate and arterial pressure than they produce. The failure of a few patients to respond despite reduction in heart rate and the failure of those who do respond to obtain the full expected benefit... | Mechanism of action of beta-blocking drugs in angina pectoris: a review. The effect of beta-blockers in improving exercise tolerance in angina pectoris can be accounted for by the reduction in heart rate and arterial pressure than they produce. The failure of a few patients to respond despite reduction in heart rate an... | [
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PMID:9631 | Effect of propranolol on mortality in patients with angina. | Two hundred and seventeen patients from general practice suffering from angina pectoris were studied over a three year period; 91 patients had beta-blocker treatment, the other 126 did not. The two groups were comparable for age, sex, blood pressure and length of history of angina. The frequency of infarction and morta... | Effect of propranolol on mortality in patients with angina. Two hundred and seventeen patients from general practice suffering from angina pectoris were studied over a three year period; 91 patients had beta-blocker treatment, the other 126 did not. The two groups were comparable for age, sex, blood pressure and length... | [
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PMID:9632 | Adverse reactions to beta-blocking drugs: a review. | Adverse reactions may occur as a predictable or unpredictable drug-induced illness can be reduced if the awareness of the prescribing doctor of clinically relevant drug and patient factors, which affect the response to the drug, can be increased. However, unexpected and unpredictable adverse reactions, sometimes report... | Adverse reactions to beta-blocking drugs: a review. Adverse reactions may occur as a predictable or unpredictable drug-induced illness can be reduced if the awareness of the prescribing doctor of clinically relevant drug and patient factors, which affect the response to the drug, can be increased. However, unexpected a... | [
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PMID:9633 | Discovery of the hypotensive effect of propranolol. | Following the observation that pronethalol lowered the blood pressure a similar effect was demonstrated with propranolol. Over a period of years propranolol was demonstrated to produce a fall in blood pressure comparable with other potent drugs with the advantage of good control of the supine blood pressure and with th... | Discovery of the hypotensive effect of propranolol. Following the observation that pronethalol lowered the blood pressure a similar effect was demonstrated with propranolol. Over a period of years propranolol was demonstrated to produce a fall in blood pressure comparable with other potent drugs with the advantage of g... | [
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PMID:9634 | The use of propranolol in hypertension: a review. | A review if given of the use of propranolol in hypertension emphasizing the importance of the studies by Prichard and Gillam in 1964 and 1969. The current use of propranolol in hypertension as regards dosage, dose intervals and starting doses is also outlined. Moreover, the combined treatment with propranolol and vasod... | The use of propranolol in hypertension: a review. A review if given of the use of propranolol in hypertension emphasizing the importance of the studies by Prichard and Gillam in 1964 and 1969. The current use of propranolol in hypertension as regards dosage, dose intervals and starting doses is also outlined. Moreover,... | [
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PMID:9635 | Indications for beta-adrenoceptor blocking drugs in hypertension. | The past 10 years have firmly established the role of beta-adrenoceptor blocking agents in the treatment of hypertension. They have been shown to lower systolic and diastolic blood pressure in the lying and standing position in mild, moderate and severe hypertension. Precise indications for beta-blockade have not yet b... | Indications for beta-adrenoceptor blocking drugs in hypertension. The past 10 years have firmly established the role of beta-adrenoceptor blocking agents in the treatment of hypertension. They have been shown to lower systolic and diastolic blood pressure in the lying and standing position in mild, moderate and severe ... | [
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PMID:9636 | Flurazepam ('Dalmane') in the treatment of insomnia in patients with respiratory disorders. | The effects on subjective aspects of sleep of flurazepam 15 mg and amylobarbitone sodium 100 mg were compared in insomniac patients with chest disease. A double-blind technique was used. The results indicate a significant superiority of flurazepam over the other drug. | Flurazepam ('Dalmane') in the treatment of insomnia in patients with respiratory disorders. The effects on subjective aspects of sleep of flurazepam 15 mg and amylobarbitone sodium 100 mg were compared in insomniac patients with chest disease. A double-blind technique was used. The results indicate a significant superi... | [
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PMID:9639 | Implications of cross inhibitory interactions of potential mediators of hormone and neurotransmitter action. | Mediators of hormone and neurotransmitter action may exert negative control on the accumulation of one another (adenosine 3':5'-cyclic monophosphate, or conversely). A model in which one agonist stimulates the formation of two mediators which inhibit each other's accumulation has been simulated. Three types of agonist-... | Implications of cross inhibitory interactions of potential mediators of hormone and neurotransmitter action. Mediators of hormone and neurotransmitter action may exert negative control on the accumulation of one another (adenosine 3':5'-cyclic monophosphate, or conversely). A model in which one agonist stimulates the f... | [
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PMID:9640 | Supersaturation in sickle cell hemoglobin solutions. | The kinetic inhibition of the gelation of hemoglobin S is compared to the change in hemoglobin S soulbility, when the solubility is altered by carbon monoxide, pH, or urea. By means of a new technique, the delay time and the extent of gelation are measured on the same sample. They delay time, td, is found to be proport... | Supersaturation in sickle cell hemoglobin solutions. The kinetic inhibition of the gelation of hemoglobin S is compared to the change in hemoglobin S soulbility, when the solubility is altered by carbon monoxide, pH, or urea. By means of a new technique, the delay time and the extent of gelation are measured on the sam... | [
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PMID:9641 | Mechanism of uncoupling in mitochondria: uncouplers as ionophores for cycling cations and protons. | Classical uncouplers such as 2,4-dinitrophenol have been shown to be ionophores with the capability for transporting monovalent or divalent cations with equal efficiency. The conditions appropriate for the maximal expression of this ionophoric capability have been explored. Two critical factors are the polarity of the ... | Mechanism of uncoupling in mitochondria: uncouplers as ionophores for cycling cations and protons. Classical uncouplers such as 2,4-dinitrophenol have been shown to be ionophores with the capability for transporting monovalent or divalent cations with equal efficiency. The conditions appropriate for the maximal express... | [
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PMID:9642 | Suppression of lytic effect of beta lactams on Escherichia coli and other bacteria. | Growth of E. coli at pH 5 protected the bacteria against the lytic effect of beta lactam antibiotics typically observed when the cells are grown at pH 7 or 7.5, i.e., the pH values routinely used in laboratory experiments. In contrast, the typical effects of beta lactam antibiotics on cellular shape and elongation and ... | Suppression of lytic effect of beta lactams on Escherichia coli and other bacteria. Growth of E. coli at pH 5 protected the bacteria against the lytic effect of beta lactam antibiotics typically observed when the cells are grown at pH 7 or 7.5, i.e., the pH values routinely used in laboratory experiments. In contrast, ... | [
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PMID:9643 | Bandage-backfall reaction: occurs in infancy, hypothalamic damage, and catalepsy. | In cataleptic clinging, produced either by catecholamine-blocking drugs or lateral hypothalamic damage in adult cats, rats, or monkeys, bandaging the face and neck causes the head to fall backwards. Early in development, a similar reaction can be seen in normal undrugged infants. | Bandage-backfall reaction: occurs in infancy, hypothalamic damage, and catalepsy. In cataleptic clinging, produced either by catecholamine-blocking drugs or lateral hypothalamic damage in adult cats, rats, or monkeys, bandaging the face and neck causes the head to fall backwards. Early in development, a similar reactio... | [
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PMID:9646 | Physiological effects of the plasminolytic derivatives of fibrinogen. | The macromolecular breakdown products of fibrinogen are known mainly for their inhibitory effect on the clotting of fibrinogen by thrombin. This inhibitory effect is due to interference with both the proteolytic action of thrombin and the polymerization of the fibrin monomers. However, the action of these products is n... | Physiological effects of the plasminolytic derivatives of fibrinogen. The macromolecular breakdown products of fibrinogen are known mainly for their inhibitory effect on the clotting of fibrinogen by thrombin. This inhibitory effect is due to interference with both the proteolytic action of thrombin and the polymerizat... | [
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PMID:9648 | Bromazepam versus diazepam in psychoneurotic inpatients. | A double blind between-groups trial was carried out to compare the effectiveness of the new benzodiazepine compound, bromazepam, (Lexotan, Ro 5-3350) as an anti-anxiety compound with that of diazepan. The fifty-eight psychoneurotic inpatients admitted to the trial were divided into two groups, "obsessives" and "neuroti... | Bromazepam versus diazepam in psychoneurotic inpatients. A double blind between-groups trial was carried out to compare the effectiveness of the new benzodiazepine compound, bromazepam, (Lexotan, Ro 5-3350) as an anti-anxiety compound with that of diazepan. The fifty-eight psychoneurotic inpatients admitted to the tria... | [
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PMID:9649 | [Practice and further development of the AMP-system (a report about a symposion and a seminar) (author's transl)]. | During two days in November 1974 TV-tapes of psychiatric interviews were demonstrated and the psychopathology was documented on AMP-record sheet 3. It was a purpose of the discussion to get stimulation for the improvement of the AMP-manual and to decrease the interrater-variance. It was only the first tape which was no... | [Practice and further development of the AMP-system (a report about a symposion and a seminar) (author's transl)]. During two days in November 1974 TV-tapes of psychiatric interviews were demonstrated and the psychopathology was documented on AMP-record sheet 3. It was a purpose of the discussion to get stimulation for... | [
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PMID:9651 | [Problems of prevention, registration and evaluation of post-vaccination neurogenic lesions in children from clinical and legal viewpoints. II. Problems in the evaluation of neurogenic post-vaccination lesions in childhood]. | On the view of neurologist the authors describe the suppositions and the special problems of diagnostic and the importance of clinical and paraclinical findings for medical vaccination reports. They examined 13 patients with neurological cerebral defects after triple vaccination (DPT). | [Problems of prevention, registration and evaluation of post-vaccination neurogenic lesions in children from clinical and legal viewpoints. II. Problems in the evaluation of neurogenic post-vaccination lesions in childhood]. On the view of neurologist the authors describe the suppositions and the special problems of di... | [
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PMID:9652 | Effects of humoral modulators and naloxone on morphine-induced changes in the spontaneous locomotor activity of the rat. | The s.c. administration of 20 mg/kg of morphine-HCl produced a decrease in the spontaneous locomotor activity (SLMA) of rats. The decrease in SLMA was significantly antagonized by p-chlorophenylalanine (p-CPA). When rats pretreated with p-CPA were given 5-hydroxytryptophan before morphine injection, the marked sedative... | Effects of humoral modulators and naloxone on morphine-induced changes in the spontaneous locomotor activity of the rat. The s.c. administration of 20 mg/kg of morphine-HCl produced a decrease in the spontaneous locomotor activity (SLMA) of rats. The decrease in SLMA was significantly antagonized by p-chlorophenylalani... | [
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PMID:9653 | Treatment of phenothiazine-induced dyskinesia. | Previous experience indicated the possibility that a serotonin antagonist substance, was effective in relieving dyskinesia as a reaction to phenothiazine antipsychotic drugs. Since the substances used in the original observations did not become available on the United States market, a compound known to be a serotonin a... | Treatment of phenothiazine-induced dyskinesia. Previous experience indicated the possibility that a serotonin antagonist substance, was effective in relieving dyskinesia as a reaction to phenothiazine antipsychotic drugs. Since the substances used in the original observations did not become available on the United Stat... | [
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PMID:9654 | Narcotic blockade, length of addiction and persistence of etonitazene consumption in rats. | Rats were given daily trials to determine relative preference for an opiate (etonitazene, ETZ) or for water. Animals with a greater history of previous drug exposure developed ETZ preferences more rapidly than did relatively drug-naive animals. Pretreatment with adequate blocking doses of naloxone reduced drug intake t... | Narcotic blockade, length of addiction and persistence of etonitazene consumption in rats. Rats were given daily trials to determine relative preference for an opiate (etonitazene, ETZ) or for water. Animals with a greater history of previous drug exposure developed ETZ preferences more rapidly than did relatively drug... | [
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PMID:9655 | On the supersensitivity of dopamine receptors, induced by neuroleptics. | Different neuroleptics caused dopamine receptor blockade (antagonism against methylphenidate-induced compulsive gnawing) for varying lengths of time. When the receptor blockade had expired, supersensitivity to dopamine agonists (occurrence of apomorphine-induced compulsive gnawing and enhancement of methylphenidate-ind... | On the supersensitivity of dopamine receptors, induced by neuroleptics. Different neuroleptics caused dopamine receptor blockade (antagonism against methylphenidate-induced compulsive gnawing) for varying lengths of time. When the receptor blockade had expired, supersensitivity to dopamine agonists (occurrence of apomo... | [
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PMID:9656 | The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidol. | Mice, administered haloperidol (3 mg/kg/d) in their drinking water for 21 days, displayed, 4 days after cessation of the haloperidol-treatment, marked locomotor stimulation to clonidine (100 or 500 mug/kg) which lasted for about 6 h. 25 mug clonidine/kg was inactive. Premedication with FLA-63 (25 mg/kg) blocked the dif... | The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidol. Mice, administered haloperidol (3 mg/kg/d) in their drinking water for 21 days, displayed, 4 days after cessation of the haloperidol-treatment, marked locomo... | [
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PMID:9657 | Changes in brain norepinephrine associated with sensitization to d-amphetamine. | Pretreatment of B6AF1/J mice with d-amphetamine HCl 10 mg/kg, twice daily for 5 days, produced a 4-fold increase in the running response to a test dose of 5 mg/kg amphetamine. Amphetamine pretreatment decreased whole-brain norepinephrine levels to 50% of control values and whole-brain dopamine to 85%. The test dose of ... | Changes in brain norepinephrine associated with sensitization to d-amphetamine. Pretreatment of B6AF1/J mice with d-amphetamine HCl 10 mg/kg, twice daily for 5 days, produced a 4-fold increase in the running response to a test dose of 5 mg/kg amphetamine. Amphetamine pretreatment decreased whole-brain norepinephrine le... | [
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PMID:9658 | Effects of a novel anti-aggressive agent upon two types of brain stimulated emotional behavior. | The effects of anti-aggressive agent Sch 12679 were evaluated upon stable baselines of rage and predation elicited by electrical stimulation of the hypothalamus in cats. Sch 12679 depressed approach and terminal aspects of both forms of attack. This is consistent with previous reports, and suggests the drug is effectiv... | Effects of a novel anti-aggressive agent upon two types of brain stimulated emotional behavior. The effects of anti-aggressive agent Sch 12679 were evaluated upon stable baselines of rage and predation elicited by electrical stimulation of the hypothalamus in cats. Sch 12679 depressed approach and terminal aspects of b... | [
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PMID:9659 | Effects of combined treatment with nortriptiline and lorazepam on conflict behavior and motility of rats. | Lorazepam attenuated the suppressant effects of punishment on the response rate of rats in the multiple schedule of reinforcement devised by Geller and Seifter (1960). Nortriptiline alone was ineffective on punished responses. Both drugs, at certain dose levels, inhibited the nonpunished response. Combined treatment wi... | Effects of combined treatment with nortriptiline and lorazepam on conflict behavior and motility of rats. Lorazepam attenuated the suppressant effects of punishment on the response rate of rats in the multiple schedule of reinforcement devised by Geller and Seifter (1960). Nortriptiline alone was ineffective on punishe... | [
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PMID:9660 | Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes. | The influence of mepiprazole (EMD 16,923), a new pyrazol-ylalkyl-piperazine derivative, on the uptake of 3H-norepinephrine (NE), 3H-dopamine (DA), and 3H-serotonin (5-HT) into rat brain synaptosomes from cerebral cortex, corpus striatum, and hypothalamus was investigated in comparison with several psychotropic drugs, i... | Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes. The influence of mepiprazole (EMD 16,923), a new pyrazol-ylalkyl-piperazine derivative, on the uptake of 3H-norepinephrine (NE), 3H-dopamine (DA), and 3H-serotonin (5-HT) into rat brain synaptosomes from cereb... | [
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PMID:9675 | Time course of free and N4-acetylated sulfapyridine concentrations in the plasma and saliva of man after sulfasalazine (salicylazosulfapyridine) administration: preliminary findings. | The time course of free and N4-acetylated sulfapyridine (SP) concentrations in the saliva and whole plasma was determined in a healthy male volunteer after a single 2.0 g oral dose of salicylazosulfapyridine (SASP) as four-500 mg commercial, uncoated tablets. The mean (+/- S.D.) plasma: saliva concentration ratios for ... | Time course of free and N4-acetylated sulfapyridine concentrations in the plasma and saliva of man after sulfasalazine (salicylazosulfapyridine) administration: preliminary findings. The time course of free and N4-acetylated sulfapyridine (SP) concentrations in the saliva and whole plasma was determined in a healthy ma... | [
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PMID:9676 | Model to study long-term effects of propoxyphene napsylate (darvon-N) on narcotic-dependent mice. | Five different strains of mice were investigated for their suitability to serve as models for the study of long-term effects of propoxyphene napsylate (PN) on narcotic-dependent mice. The NIH/Swiss outbred strain proved to be most suitable because of its high liability to manifest physical dependence on morphine. Follo... | Model to study long-term effects of propoxyphene napsylate (darvon-N) on narcotic-dependent mice. Five different strains of mice were investigated for their suitability to serve as models for the study of long-term effects of propoxyphene napsylate (PN) on narcotic-dependent mice. The NIH/Swiss outbred strain proved to... | [
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PMID:9677 | In vitro studies on the antimicrobial effects of colostrum and milk from vaccinated and unvaccinated pigs on Escherichia coli. | Unsupplemented porcine colostrum and milk exhibited a powerful bactericidal effect for porcine strains of E coli incubated in vitro at 37 degrees C. This activity was independent of complement but was susceptible to acid pH, to the presence of soluble iron and to the selective immunoprecipitation of IgG, IgA and IgM. M... | In vitro studies on the antimicrobial effects of colostrum and milk from vaccinated and unvaccinated pigs on Escherichia coli. Unsupplemented porcine colostrum and milk exhibited a powerful bactericidal effect for porcine strains of E coli incubated in vitro at 37 degrees C. This activity was independent of complement ... | [
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PMID:9678 | Aquatic life at high altitude: respiratory adaptations in the Lake Titicaca frog, Telmatobius culeus. | Telmatobius culeus has a combination of behavioral, morphological and physiological adaptations which allows an aquatic life in cool (10 degrees C) O2-saturated (at 100 mm Hg) waters at high altitude (3812 m). The skin surgace area is increased by pronounced folds and the cutaneous capillaries penetrate to the outer la... | Aquatic life at high altitude: respiratory adaptations in the Lake Titicaca frog, Telmatobius culeus. Telmatobius culeus has a combination of behavioral, morphological and physiological adaptations which allows an aquatic life in cool (10 degrees C) O2-saturated (at 100 mm Hg) waters at high altitude (3812 m). The skin... | [
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PMID:9679 | The oxygen affinity of chicken haemoglobin in whole blood and erythrocyte suspensions. | The oxygen equilibrium of whole chicken blood has a P50 of 52.3 mm Hg and a Hill coefficient of 2.6 at pH 7.4 and 37 degrees C when determined with new microtechniques which are not vitiated by cellular respiration. The apparent failure of the haemoglobin to reach full saturation at arterial PO2 IS DISCUSSED IN RELATIO... | The oxygen affinity of chicken haemoglobin in whole blood and erythrocyte suspensions. The oxygen equilibrium of whole chicken blood has a P50 of 52.3 mm Hg and a Hill coefficient of 2.6 at pH 7.4 and 37 degrees C when determined with new microtechniques which are not vitiated by cellular respiration. The apparent fail... | [
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PMID:9682 | [The role of arthropods as vector agents in viral hepatitis]. | The increased incidence during the last years of viral hepatitis demands a new approach to the various eventual possibilities of contamination. The author discusses the transmission of serum hepatitis by mosquitoes, especially in warm climates, and the recent results obtained in investigations on the mechanical or biol... | [The role of arthropods as vector agents in viral hepatitis]. The increased incidence during the last years of viral hepatitis demands a new approach to the various eventual possibilities of contamination. The author discusses the transmission of serum hepatitis by mosquitoes, especially in warm climates, and the recen... | [
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PMID:9689 | The value of epicillin and ampicillin in the treatment of meningococcal and pneumococcal meningitis. | 96 patients with meningitis due to Neisseria meningitidis and Diplococcus pneumoniae were treated with epicillin or ampicillin according to a predesigned randomization chart. Results indicate that epicillin and ampicillin are effective single drugs in the treatment of meningococcal and pneumococcal meningitis. No adver... | The value of epicillin and ampicillin in the treatment of meningococcal and pneumococcal meningitis. 96 patients with meningitis due to Neisseria meningitidis and Diplococcus pneumoniae were treated with epicillin or ampicillin according to a predesigned randomization chart. Results indicate that epicillin and ampicill... | [
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PMID:9688 | Disorders induced by pheochromocytoma in the cardiovascular system. A therapeutic approach. | The diagnosis of pheochromocytoms is still made only post mortem in a high percentage of the cases. It is important to know both the diversity of clinical forms (of the 16 cases investigated 13 (80%) presented permanent AH, of which 12 cases with paroxysmal attacks, followed by collapse only in one case, and 3 (20%) wi... | Disorders induced by pheochromocytoma in the cardiovascular system. A therapeutic approach. The diagnosis of pheochromocytoms is still made only post mortem in a high percentage of the cases. It is important to know both the diversity of clinical forms (of the 16 cases investigated 13 (80%) presented permanent AH, of w... | [
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PMID:9692 | Cholinergic stimulation of the rat hypothalamus: effects of liver glycogen synthesis. | Cholinergic stimulation of the lateral hypothalamic neurons with intrahypothalamic microinjections of acetylcholine or carbachol caused a marked increase in the content of the active form of glycogen (starch) synthase in the liver. Total activity of the enzyme (active plus inactive forms) was not increased significantl... | Cholinergic stimulation of the rat hypothalamus: effects of liver glycogen synthesis. Cholinergic stimulation of the lateral hypothalamic neurons with intrahypothalamic microinjections of acetylcholine or carbachol caused a marked increase in the content of the active form of glycogen (starch) synthase in the liver. To... | [
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PMID:9696 | Beta-blockers and the central nervous system. | Some of the interesting points which emerged from an international symposium on beta-blockers and the central nervous system, held in St Moritz in January 1976, are presented. Fifty-eight participants from 12 countries attended the symposium. | Beta-blockers and the central nervous system. Some of the interesting points which emerged from an international symposium on beta-blockers and the central nervous system, held in St Moritz in January 1976, are presented. Fifty-eight participants from 12 countries attended the symposium. | [
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PMID:9697 | Somatostatin, 1976. | Somatostatin, a growth hormone release-inhibiting factor, isolated originally from the hypothalamus, has been shown to have widespread effects on brain and endocrine and exocrine pancreatic and gut function. Furthermore, it has a widespread distribution in the CNS, gut and C cells of the thyroid -- cells which probably... | Somatostatin, 1976. Somatostatin, a growth hormone release-inhibiting factor, isolated originally from the hypothalamus, has been shown to have widespread effects on brain and endocrine and exocrine pancreatic and gut function. Furthermore, it has a widespread distribution in the CNS, gut and C cells of the thyroid -- ... | [
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PMID:9699 | Severe ischemia of the hand following radial artery catheterization. | Percutaneous radial artery catheterization for blood gas monitoring and continuous arterial pressure recording has become a common place procedure in the management of critically ill patients. Five patients with severe ischemia after cannulation have been encountered in the past 20 months, four of whom lost segments of... | Severe ischemia of the hand following radial artery catheterization. Percutaneous radial artery catheterization for blood gas monitoring and continuous arterial pressure recording has become a common place procedure in the management of critically ill patients. Five patients with severe ischemia after cannulation have ... | [
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PMID:9702 | Bacterial precipitins and their immunoglobulin class in atopic asthma, non-atopic asthma, and chronic bronchitis. | In a study of groups of patients with atopic (extrinsic) asthma, non-atopic (intrinsic) asthma, and chronic bronchitis, no difference could be detected in the numbers having precipitating antibodies against species specific antigens from Staphylococcus aureus or Streptococcus pneumoniae compared to suitably matched con... | Bacterial precipitins and their immunoglobulin class in atopic asthma, non-atopic asthma, and chronic bronchitis. In a study of groups of patients with atopic (extrinsic) asthma, non-atopic (intrinsic) asthma, and chronic bronchitis, no difference could be detected in the numbers having precipitating antibodies against... | [
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PMID:9703 | The effect of beta adrenergic blockade upon exercise-induced changes in blood coagulation and fibrinolysis. | Exercise stress is known to stimulate blood coagulation and fibrinolysis possibly as a result of sympatho-adrenal stimulation of the beta adrenergic receptor. In order to test this hypothesis five men exercised on four separate occasions with and without prior beta adrenergic blockade with oxprenolol, propranolol and p... | The effect of beta adrenergic blockade upon exercise-induced changes in blood coagulation and fibrinolysis. Exercise stress is known to stimulate blood coagulation and fibrinolysis possibly as a result of sympatho-adrenal stimulation of the beta adrenergic receptor. In order to test this hypothesis five men exercised o... | [
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PMID:9704 | Studies on the action mechanism of the antihemostatic effect of lodopeptides. | A synthetic iodopeptide having a glutamic acid-diiodotyrosine molar ratio of 1:1 has been shown to be an effective anticoagulant both in vivo and in vitro. Contrasted with heparin the following general conclusions may be made regarding its action. The iodopeptide does not act through the inactivation of thrombin in pla... | Studies on the action mechanism of the antihemostatic effect of lodopeptides. A synthetic iodopeptide having a glutamic acid-diiodotyrosine molar ratio of 1:1 has been shown to be an effective anticoagulant both in vivo and in vitro. Contrasted with heparin the following general conclusions may be made regarding its ac... | [
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PMID:9712 | Canine allogeneic bone marrow transplantation. Technique and variables influencing engraftment. | We have studied the toxicity and immune suppression of supralethal total body irradiation (800-2000 rads, 60Co) at three dose intensities (10 rads/min, 49 rads/min, and 100 rads/min). In 79 intensively supported radiation control animals, the LD50(5) (tn 5 days) for these dose intensities is estimated to be 1556, 941, ... | Canine allogeneic bone marrow transplantation. Technique and variables influencing engraftment. We have studied the toxicity and immune suppression of supralethal total body irradiation (800-2000 rads, 60Co) at three dose intensities (10 rads/min, 49 rads/min, and 100 rads/min). In 79 intensively supported radiation co... | [
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PMID:9713 | Graft-versus-host reactivity and renal allograft survival in rats given allogeneic spleen cells or spleen allografts. | Selective recruitment of antigen-sensitive cells (ASC) into the spleen as a method of inducing specific suppression was attempted by intravenous injection of either DA or Lewis spleen cells 24 hr before a (DA X Lewis)F1 renal allograft into a Lewis or DA recipient, either with or without a splenectomy. This led to supp... | Graft-versus-host reactivity and renal allograft survival in rats given allogeneic spleen cells or spleen allografts. Selective recruitment of antigen-sensitive cells (ASC) into the spleen as a method of inducing specific suppression was attempted by intravenous injection of either DA or Lewis spleen cells 24 hr before... | [
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PMID:9714 | Disseminated systemic expression of the "local" popliteal lymph node assay in rats. | In contrast to the traditional belief that the popliteal lymph node (PLN) assay of graft-versus-host (GVH) reactivity is a local phenomenon, this study describes significant systemic components of both donor and host lymphoid cell activity. Not only are host radiosensitive lymphocytes of systemic origin necessary for t... | Disseminated systemic expression of the "local" popliteal lymph node assay in rats. In contrast to the traditional belief that the popliteal lymph node (PLN) assay of graft-versus-host (GVH) reactivity is a local phenomenon, this study describes significant systemic components of both donor and host lymphoid cell activ... | [
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PMID:9715 | Infection rate of arboviruses in Dutch recruits returning from Surinam. | Paired serum samples from approximately 650 Dutch recruits residing temporarily in Surinam, the first sample being collected on arrival, the second when leaving the country, were examined for haemagglutination-inhibiting antibodies to two types of arbovirus (Mucambo and Restan) isolated from local mosquitoes, and to tw... | Infection rate of arboviruses in Dutch recruits returning from Surinam. Paired serum samples from approximately 650 Dutch recruits residing temporarily in Surinam, the first sample being collected on arrival, the second when leaving the country, were examined for haemagglutination-inhibiting antibodies to two types of ... | [
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PMID:9723 | Sipple's syndrome. A urologist's viewpoint. | A case of Sipple's syndrome, a triad of medullary carcinoma of the thyroid, pheochromocytoma, and parathyroid hyperplasia is presented. The cause, laboratory diagnosis, and operative management of the syndrome are discussed. The need for thorough endocrine screening of patients with pheochromocytoma and family screenin... | Sipple's syndrome. A urologist's viewpoint. A case of Sipple's syndrome, a triad of medullary carcinoma of the thyroid, pheochromocytoma, and parathyroid hyperplasia is presented. The cause, laboratory diagnosis, and operative management of the syndrome are discussed. The need for thorough endocrine screening of patien... | [
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PMID:9724 | Disorders of micturition: neuropharmacologic basis and results of drug therapy. | The clinical use of various pharmacologic agents in problems of micturition is based on the new concepts of intrinsic urethrovesical innervation, presence and regional predominance of autonomic neuroreceptors, and experimental evidence of the effects of various drugs on the bladder and the urethra. A new concept, relat... | Disorders of micturition: neuropharmacologic basis and results of drug therapy. The clinical use of various pharmacologic agents in problems of micturition is based on the new concepts of intrinsic urethrovesical innervation, presence and regional predominance of autonomic neuroreceptors, and experimental evidence of t... | [
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PMID:9725 | Host factors in urinary infections. | To prevent the urologist from becoming simply a urinary tract mechanic we must develop more specific tests, perfect present tests and use these tests to elicit faulty mechanisms of host resistance of patients with urinary tract infections. We must then provide, from our research information, therapeutic measures to pro... | Host factors in urinary infections. To prevent the urologist from becoming simply a urinary tract mechanic we must develop more specific tests, perfect present tests and use these tests to elicit faulty mechanisms of host resistance of patients with urinary tract infections. We must then provide, from our research info... | [
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PMID:9728 | Physical and chemical changes of ACD-preserved blood: a comparison of blood in glass bottles and plastic bags. | ACD blood was preserved in glass bottles with or without aeration and in plastic bags in air or nitrogen gas at 4.5 degrees C. The blood was examined for physical and chemical changes of erythrocyte membrane resistance, hemoglobin in the plasma, the viscosity of the blood, pH of plasma, and ATP and 2,3-DPG content of e... | Physical and chemical changes of ACD-preserved blood: a comparison of blood in glass bottles and plastic bags. ACD blood was preserved in glass bottles with or without aeration and in plastic bags in air or nitrogen gas at 4.5 degrees C. The blood was examined for physical and chemical changes of erythrocyte membrane r... | [
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PMID:9732 | [Metabolic disorders in the acute stage of cardiac infarction]. | The level of lactates and pyruvates in arterial blood of 35 patients with myocardial infarction without shock (17-without heart insufficiency and 18-with manifested but in various degrees) is higher as compared with the level of 18 healthy subject and the elevation is better manifested in the patients with cardiac insu... | [Metabolic disorders in the acute stage of cardiac infarction]. The level of lactates and pyruvates in arterial blood of 35 patients with myocardial infarction without shock (17-without heart insufficiency and 18-with manifested but in various degrees) is higher as compared with the level of 18 healthy subject and the ... | [
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PMID:9733 | [Integrated stimulation test with releasing hormones on healthy men and on patients with various forms of male hypogonadism]. | Ninety subjects were examined; 20 healthy males, 20 patients with primary hypogonadism, 30 patients with Klinefelter's syndrome and 20 patients with secondary hypogonadism. The stimulating test with 200 mug LH-RH and 200 mug TTH was carried out tp all subjects examined, applied in two successive o.v. injections. The pl... | [Integrated stimulation test with releasing hormones on healthy men and on patients with various forms of male hypogonadism]. Ninety subjects were examined; 20 healthy males, 20 patients with primary hypogonadism, 30 patients with Klinefelter's syndrome and 20 patients with secondary hypogonadism. The stimulating test ... | [
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PMID:9734 | Effect of aqueous extract of Eugenia caryophyllus on brain acetylcholine esterase in rats. | The effect of aqueous extract of Eugenia caryophyllus on brain acetylcholine esterase (AChE) activity in rats was studied. Results indicate that the aqueous extract reduced the hydrolysis of acetylcholine (ACh) by AChE. This reducing effect was not due to the acidic nature of the extract and suggests that Eugenia caryo... | Effect of aqueous extract of Eugenia caryophyllus on brain acetylcholine esterase in rats. The effect of aqueous extract of Eugenia caryophyllus on brain acetylcholine esterase (AChE) activity in rats was studied. Results indicate that the aqueous extract reduced the hydrolysis of acetylcholine (ACh) by AChE. This redu... | [
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PMID:9742 | Properties of proteolytic enzymes isolated from a thermophilic strain of Micromonospora vulgaris 42. | Two proteolytic enzymes, protease A and protease B, were isolated in homogeneous state from the cultural broth of the thermophilic actinomycete Micromonospora vulgaris 42. Their physicochemical properties were studied, i.e., molecular weight (50 000 for protease A and 30 000 for protease B), amino acid composition, N-t... | Properties of proteolytic enzymes isolated from a thermophilic strain of Micromonospora vulgaris 42. Two proteolytic enzymes, protease A and protease B, were isolated in homogeneous state from the cultural broth of the thermophilic actinomycete Micromonospora vulgaris 42. Their physicochemical properties were studied, ... | [
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PMID:9743 | Histone-like protein fractions of Kluyveromyces fragilis and their relation to the cell cycle. | Protein fractions were obtained from Kluyveromyces fragilis by pH titration, a technique used for histone extraction, following the inclusion of a distilled water extraction stage, and the fractions partially characterized. The inclusion of a distilled water step resulted in a tenfold purification of the fraction obtai... | Histone-like protein fractions of Kluyveromyces fragilis and their relation to the cell cycle. Protein fractions were obtained from Kluyveromyces fragilis by pH titration, a technique used for histone extraction, following the inclusion of a distilled water extraction stage, and the fractions partially characterized. T... | [
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PMID:9747 | [Malabsorption caused by HBsAg-positive panareteritis nodosa]. | A 36 year old man with panarteriitis nodosa (PAN) presented over a certain period of time meinly with gastrointestinal symptoms. He was HBsAg positive and a "reactive" hepatitis with histologically demonstrated. Arterial microaneurysms and stenoses were detected by angiography in the liver, kidney and small intestine. ... | [Malabsorption caused by HBsAg-positive panareteritis nodosa]. A 36 year old man with panarteriitis nodosa (PAN) presented over a certain period of time meinly with gastrointestinal symptoms. He was HBsAg positive and a "reactive" hepatitis with histologically demonstrated. Arterial microaneurysms and stenoses were det... | [
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PMID:9754 | [Maldescensus testis (author's transl)]. | During the last years numerous publications about clinical, endocrinologic, histologic, and animal experimental examinations for maldescensus have been made intending to find the most favourable time of therapy for obtaining fertility later on. Since the results partially differ considerably and even the findings in th... | [Maldescensus testis (author's transl)]. During the last years numerous publications about clinical, endocrinologic, histologic, and animal experimental examinations for maldescensus have been made intending to find the most favourable time of therapy for obtaining fertility later on. Since the results partially differ... | [
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PMID:9756 | [The transfer of drugs into the amniotic fluid]. | On the basis of the present literature and our own results a review will be given about the importance of the physico-chemical properties of drugs and of different factors of biological system "mother, fetus and amniotic fluid" for the passage of drugs into amniotic fluid. The amniotic fluid is relieved as a possible d... | [The transfer of drugs into the amniotic fluid]. On the basis of the present literature and our own results a review will be given about the importance of the physico-chemical properties of drugs and of different factors of biological system "mother, fetus and amniotic fluid" for the passage of drugs into amniotic flui... | [
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PMID:9757 | Alkaline ribonuclease from rye germ cytosol. | 1. Alkaline ribonuclease (pH optimum 7.6) was isolated from rye (Secale cereale L) germ cytosol and partially purified; the preparation was devoid of other nucleolytic activities. 2. The enzyme is a typical endonuclease hydrolysing all phosphodiester bonds in RNA, yielding ultimately purine and pyrimidine nucleoside 2'... | Alkaline ribonuclease from rye germ cytosol. 1. Alkaline ribonuclease (pH optimum 7.6) was isolated from rye (Secale cereale L) germ cytosol and partially purified; the preparation was devoid of other nucleolytic activities. 2. The enzyme is a typical endonuclease hydrolysing all phosphodiester bonds in RNA, yielding u... | [
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PMID:9752 | [Fatal kidney diseases due to analogesic abuse in Switzerland]. | As part of an investigation into death by poisoning in Switzerland we were able to examine the register of deaths at the Swiss Federal Bureau of Statistics. All the medical reports which named analgesic nephropathy as being the basic illness and the main cause of death have been taken into consideration in this work. 3... | [Fatal kidney diseases due to analogesic abuse in Switzerland]. As part of an investigation into death by poisoning in Switzerland we were able to examine the register of deaths at the Swiss Federal Bureau of Statistics. All the medical reports which named analgesic nephropathy as being the basic illness and the main c... | [
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PMID:9758 | Inhibition by alanine of AMP-deaminase from rabbit skeletal muscle. | 1. Alanine inhibits rabbit muscle AMP-deaminase while aspartate, histidine and glutamate are ineffective. 2. The degree and type of inhibition of AMP-deaminase by alanine depend on pH; at pH 6.5 alanine behaves like an allosteric effector exerting a negative heterotropic effect. At pH 7.0 the inhibition is non-competit... | Inhibition by alanine of AMP-deaminase from rabbit skeletal muscle. 1. Alanine inhibits rabbit muscle AMP-deaminase while aspartate, histidine and glutamate are ineffective. 2. The degree and type of inhibition of AMP-deaminase by alanine depend on pH; at pH 6.5 alanine behaves like an allosteric effector exerting a ne... | [
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PMID:9753 | [Drugs and their way of application in juvenile drug abuse. A dimension-analytical study of consumption habits]. | In a sample of 382 heavy users mode and extent of drug abuse were inquired. Factor analysis of the data gave three factors named "i.v. applicated illegal drugs", "oral applicated illegal drugs" and "oral applicated medicaments" for short. Results show that attitudes of the drug users towards their drug uses are strongl... | [Drugs and their way of application in juvenile drug abuse. A dimension-analytical study of consumption habits]. In a sample of 382 heavy users mode and extent of drug abuse were inquired. Factor analysis of the data gave three factors named "i.v. applicated illegal drugs", "oral applicated illegal drugs" and "oral app... | [
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PMID:9759 | Regulation of aconitate hydratase activity from rat kidney cortex by bicarbonate. | 1. The increase in pH value and bicarbonate concentration stimulated citrate synthesis from pyruvate and malate, inhibiting simultaneously conversion of isocitrate to citrate. 2. Bicarbonate inhibited competitively the activity of aconitate hydratase, probably binding with the two active sites of the enzyme. The Ki val... | Regulation of aconitate hydratase activity from rat kidney cortex by bicarbonate. 1. The increase in pH value and bicarbonate concentration stimulated citrate synthesis from pyruvate and malate, inhibiting simultaneously conversion of isocitrate to citrate. 2. Bicarbonate inhibited competitively the activity of aconita... | [
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PMID:9760 | Trypsin inhibitors in bovine lung and pancreas during development. | 1. The activity of trypsin inhibitors in lung and pancreas increased with age of the animals. 2. In foetal lung the activity of the basic Kunitz-type inhibitor was 1% that, and in calf lung 5-30% that, found in adult animals. 3. In foetal pancreas the basic Kunitz-type inhibitor was not detected, and in calf pancreas i... | Trypsin inhibitors in bovine lung and pancreas during development. 1. The activity of trypsin inhibitors in lung and pancreas increased with age of the animals. 2. In foetal lung the activity of the basic Kunitz-type inhibitor was 1% that, and in calf lung 5-30% that, found in adult animals. 3. In foetal pancreas the b... | [
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PMID:9761 | Inhibition of Ca++-stimulated respiration by uncouplers. | In a phosphate medium at pH 6.6 low concentrations of uncouplers such as p-trifluoromethoxyphenylhydrazone carbonylcyanide and 2,4-dinitrophenol inhibit the oxidation of beta-hydroxybutyrate and succinate, when added during Ca++-accumulation. The inhibition depends on the amount of accumulated Ca++, and is released by ... | Inhibition of Ca++-stimulated respiration by uncouplers. In a phosphate medium at pH 6.6 low concentrations of uncouplers such as p-trifluoromethoxyphenylhydrazone carbonylcyanide and 2,4-dinitrophenol inhibit the oxidation of beta-hydroxybutyrate and succinate, when added during Ca++-accumulation. The inhibition depen... | [
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PMID:9762 | [Inhibition of the malic enzyme from Acinetobacter calcoaceticus by NADPH and NADH]. | The malic enzyme enriched from Acinetobacter calcoaceticus is inhibited by NADPH and NADH. The inhibition afforded by the reduced coenzymes is not affected by NAD+, AMP and 3'.5'-AMP. Against L-malate, NADPH inhibits the enzyme in a noncompetitive linear fashion (Ki = 1.5 x 10(-4) M), against NADP+, competitively linea... | [Inhibition of the malic enzyme from Acinetobacter calcoaceticus by NADPH and NADH]. The malic enzyme enriched from Acinetobacter calcoaceticus is inhibited by NADPH and NADH. The inhibition afforded by the reduced coenzymes is not affected by NAD+, AMP and 3'.5'-AMP. Against L-malate, NADPH inhibits the enzyme in a no... | [
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PMID:9763 | [Oxygen binding of hemoglobin following covalent fixation in the deoxy- and oxy- conformation]. | Deoxyhemoglobin (deoxyHB) and oxyhemoglobin (HbO2) were covalently fixed to BrCN-activated Sephadex G-200. At pH 6, the oxygen semi-saturation pressure for the deoxyHb coupling product was 14.1, and for the HbO2 coupling product, 7.2 mm Hg. The alkaline Bohr effect delta was calculated to be - 0.55 and - 0.4 respective... | [Oxygen binding of hemoglobin following covalent fixation in the deoxy- and oxy- conformation]. Deoxyhemoglobin (deoxyHB) and oxyhemoglobin (HbO2) were covalently fixed to BrCN-activated Sephadex G-200. At pH 6, the oxygen semi-saturation pressure for the deoxyHb coupling product was 14.1, and for the HbO2 coupling pro... | [
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PMID:9765 | [Intracellular protein breakdown. VI. Isolation, properties and biological significance of cathepsin D from rat liver]. | The preparation and properties of cathepsin D from rat liver are reported. The enzyme is an endopeptidase of lysosomal origin. The molecular weight was estimated to be 49000 by sodium-dodecylsulfate electrophoresis. We did not find any dissociation into subunits under reducing conditions, in contrast to some other auth... | [Intracellular protein breakdown. VI. Isolation, properties and biological significance of cathepsin D from rat liver]. The preparation and properties of cathepsin D from rat liver are reported. The enzyme is an endopeptidase of lysosomal origin. The molecular weight was estimated to be 49000 by sodium-dodecylsulfate e... | [
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PMID:9766 | [Intracellular protein breakdown. VII. Cathepsin L and H; two new proteinases from rat liver lysosomes]. | Some properties (molecular weight, pI, temperature stability, action of selected inhibitors, substrate specificity and pH-activity dependence) of two not yet known cathepsins from rat liver lysosomes are compared with the properties of the known cathepsin B1. Cathepsin L is a thiolproteinase, has a molecular weight of ... | [Intracellular protein breakdown. VII. Cathepsin L and H; two new proteinases from rat liver lysosomes]. Some properties (molecular weight, pI, temperature stability, action of selected inhibitors, substrate specificity and pH-activity dependence) of two not yet known cathepsins from rat liver lysosomes are compared wi... | [
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PMID:9767 | [Influence of glutathione on the catalytic properties of leucine aminopeptidase]. | 1. Leucine aminopeptidase does not catalyze the hydrolysis of glutathione. 2. Glutathione inhibits the hydrolysis of the substrates leucine hydrazide and leucine-p-nitroanilide by leucine aminopeptidase. 3. By means of kinetic experiments the type of the inhibition has been determined as noncompetitive. The inhibition ... | [Influence of glutathione on the catalytic properties of leucine aminopeptidase]. 1. Leucine aminopeptidase does not catalyze the hydrolysis of glutathione. 2. Glutathione inhibits the hydrolysis of the substrates leucine hydrazide and leucine-p-nitroanilide by leucine aminopeptidase. 3. By means of kinetic experiments... | [
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PMID:9768 | Binding of tritiated methylated luteinizing hormone to bovine corpus luteum receptors. | The binding of luteinizing hormone (LH) to cow corpora lutea homogenates was studied using a tritium labelled hormone obtained by reductive methylation. The KD observed was 0.9 10(-10) M and the number of sites was the equivalent of 0.4 10(-15) moles per mg of wet tissue. The influence of the pH and temperature was exa... | Binding of tritiated methylated luteinizing hormone to bovine corpus luteum receptors. The binding of luteinizing hormone (LH) to cow corpora lutea homogenates was studied using a tritium labelled hormone obtained by reductive methylation. The KD observed was 0.9 10(-10) M and the number of sites was the equivalent of ... | [
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0.0253656... |
PMID:9770 | A descriptive and comparative study of oral health in 8-year-old Swedish children. | The aim of the study was to assess the oral health of a group of children, and to compare the findings with the results from an investigation performed 4 years earlier in children of the same age and living in the same area. The material consisted of 149 randomly selected 8-year-old children. The study included examina... | A descriptive and comparative study of oral health in 8-year-old Swedish children. The aim of the study was to assess the oral health of a group of children, and to compare the findings with the results from an investigation performed 4 years earlier in children of the same age and living in the same area. The material... | [
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PMID:9771 | Inorganic pyrophosphatase in isolated enamel organ and odontoblasts from the rat incisor. | The inorganic pyrophosphatase (PPiase) activity was determined by a colorimetric method in the odontoblasts and the parts of the enamel organ related to enamel matrix formation and enamel maturation. The effects on PPi hydrolysis by EDTA, R 8231, urea and heat treatment were found to be almost identical to those report... | Inorganic pyrophosphatase in isolated enamel organ and odontoblasts from the rat incisor. The inorganic pyrophosphatase (PPiase) activity was determined by a colorimetric method in the odontoblasts and the parts of the enamel organ related to enamel matrix formation and enamel maturation. The effects on PPi hydrolysis ... | [
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0.021563682705163956,
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0.04... |
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