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PMID:16065 | Purification and immunochemical characterization of the outer membrane complex of Bacteroides melaninogenicus subspecies asaccharolyticus. | Morphologic study of Bacteroides melaninogenicus subspecies asaccharolyticus by electron microscopy disclosed the presence of a capsule and a cell wall structure otherwise typical of a gram-negative organism. An outer membrane complex was isolated with use of gentle methods. Relative purity of the preparation was confi... | Purification and immunochemical characterization of the outer membrane complex of Bacteroides melaninogenicus subspecies asaccharolyticus. Morphologic study of Bacteroides melaninogenicus subspecies asaccharolyticus by electron microscopy disclosed the presence of a capsule and a cell wall structure otherwise typical o... | [
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PMID:16068 | A simple method for the separate measurement of transcobalamins I, II, and III: normal ranges in serum and plasma in men and women. | A simple method for the separate measurement of the unsaturated binding capacity of the three main circulating vitamin B12 binders, transcobalamins (TCs) I, II, and III, is described. The method involves batch separation of TC I and III from TC II by means of Quso G32, followed by batch separation of TC I from TC II w... | A simple method for the separate measurement of transcobalamins I, II, and III: normal ranges in serum and plasma in men and women. A simple method for the separate measurement of the unsaturated binding capacity of the three main circulating vitamin B12 binders, transcobalamins (TCs) I, II, and III, is described. The... | [
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PMID:16069 | Mechanism by which neutral phosphate infusion elevates urine PCO2. | Currently, the ability to elevate the urine PCO2 above that of the arterial blood is employed as an estimate of distal hydrogen ion secretion. Therefore, it is important to establish the mechanisms by which various factors affect the urine CO2 tension. This paper examines the physiologic process by which phosphate elev... | Mechanism by which neutral phosphate infusion elevates urine PCO2. Currently, the ability to elevate the urine PCO2 above that of the arterial blood is employed as an estimate of distal hydrogen ion secretion. Therefore, it is important to establish the mechanisms by which various factors affect the urine CO2 tension. ... | [
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PMID:16070 | Kinetics of the cyanate-hemoglobin reaction in whole blood. | The kinetics of the cyanate-hemoglobin reaction in normal whole blood have been investigated. The mechanism was found to be second order, irreversible, bimolecular. The influence of the temperature, pH, Po2, and Pco2 on the reaction rate constant was examined. A temperature change from 37 degrees to 42 degrees C, resul... | Kinetics of the cyanate-hemoglobin reaction in whole blood. The kinetics of the cyanate-hemoglobin reaction in normal whole blood have been investigated. The mechanism was found to be second order, irreversible, bimolecular. The influence of the temperature, pH, Po2, and Pco2 on the reaction rate constant was examined.... | [
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PMID:16071 | Use of a competitive protein-binding assay for adenosine 3':5'-phosphate for the study of bovine corpus luteum adenylate cyclase. | The use of a competitive protein-binding assay for cyclic AMP, utilizing the binding protein purified from bovine adrenal cortex, for the study of adenylate cyclase activity of the washed 600 g sediment of bovine corpus luteum is validated. A specific assay for cyclic AMP could only be achieved by removal of the degrad... | Use of a competitive protein-binding assay for adenosine 3':5'-phosphate for the study of bovine corpus luteum adenylate cyclase. The use of a competitive protein-binding assay for cyclic AMP, utilizing the binding protein purified from bovine adrenal cortex, for the study of adenylate cyclase activity of the washed 60... | [
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PMID:16072 | Expression of endogenous murine leukemia viruses during the course of a protracted immunological disorder. | Mice of the low leukemia (BALB/cJ x A/J)F1 hybrid (CAF1) strain express B-and N-tropic infectious murine leukemia virus (MuLV) after the age of 6 mo. Initation of a protracted immunological disorder, the graft-versus-host reaction (GVHR), at 7 wk of age, accelerates the induction of both these mouse-tropic endogenous v... | Expression of endogenous murine leukemia viruses during the course of a protracted immunological disorder. Mice of the low leukemia (BALB/cJ x A/J)F1 hybrid (CAF1) strain express B-and N-tropic infectious murine leukemia virus (MuLV) after the age of 6 mo. Initation of a protracted immunological disorder, the graft-ver... | [
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PMID:16073 | The Ly phenotype of suppressor T cells arising in mice subjected to a graft-versus-host reaction. | T cells with helper and suppressor functions arising during graft-versus-host reaction (B6 vs. BDF1) have been characterized with respect to their Ly surface antigens. Helper cells were found to express the phenotype Ly 1+2- and suppressor cells the phenotype Ly 1+2+. Ly 1-2+ T cells had no suppressive effect in this s... | The Ly phenotype of suppressor T cells arising in mice subjected to a graft-versus-host reaction. T cells with helper and suppressor functions arising during graft-versus-host reaction (B6 vs. BDF1) have been characterized with respect to their Ly surface antigens. Helper cells were found to express the phenotype Ly 1+... | [
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PMID:16078 | The pH-dependent rate of action of local anesthetics on the node of Ranvier. | Local anesthetic solutions were applied suddenly to the outside of single myelinated nerve fibers to measure the time course of development of block of sodium channels. Sodium currents were measured under voltage clamp with test pulses applied several times per second during the solution change. The rate of block was s... | The pH-dependent rate of action of local anesthetics on the node of Ranvier. Local anesthetic solutions were applied suddenly to the outside of single myelinated nerve fibers to measure the time course of development of block of sodium channels. Sodium currents were measured under voltage clamp with test pulses applied... | [
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PMID:16079 | Lack of a regulatory function for glutamine synthetase protein in the synthesis of glutamate dehydrogenase and nitrite reductase in Escherichia coli K12. | Synthesis of glutamine synthetase (GS) in anaerobic batch cultures of Escherichia coli was repressed when excess NH4+ was available, but derepressed during growth with a poor nitrogen source. In wild-type bacteria there was only a weak inverse correlation between the activities of GS and glutamate dehydrogenase (GDH) d... | Lack of a regulatory function for glutamine synthetase protein in the synthesis of glutamate dehydrogenase and nitrite reductase in Escherichia coli K12. Synthesis of glutamine synthetase (GS) in anaerobic batch cultures of Escherichia coli was repressed when excess NH4+ was available, but derepressed during growth wit... | [
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PMID:16080 | Evaluation of the role of methional, 2-keto-4-methylthiobutyric acid and peroxidase in ethylene formation by Escherichia coli. | During growth of Escherichia coli strain SPA O in the presence of methionine, an intermediate accumulates in the medium. This intermediate reacts with 2,4-dinitrophenylhydrazine, and can be degraded to ethylene either enzymically or photochemically, the latter being stimulated by the addition of a flavin. The pH optimu... | Evaluation of the role of methional, 2-keto-4-methylthiobutyric acid and peroxidase in ethylene formation by Escherichia coli. During growth of Escherichia coli strain SPA O in the presence of methionine, an intermediate accumulates in the medium. This intermediate reacts with 2,4-dinitrophenylhydrazine, and can be deg... | [
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PMID:16081 | Effect of chaotropic salts and protein denaturants on the thermal stability of mouse fibroblast interferon. | Altering the aqueous environment, especially with agents that affect hydrogen bonds, markedly affects the stability of mouse L cell interferon. Low pH stabilizes interferon whereas high pH labilizes it; heavy water further enhances interferon thermostability at pH 2 but not at pH 9. Exposure to the protein denaturants,... | Effect of chaotropic salts and protein denaturants on the thermal stability of mouse fibroblast interferon. Altering the aqueous environment, especially with agents that affect hydrogen bonds, markedly affects the stability of mouse L cell interferon. Low pH stabilizes interferon whereas high pH labilizes it; heavy wat... | [
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PMID:16082 | Changes in primary process expression in hospitalized schizophrenics treated with phenothiazines: two projective tasks compared. | It was hypothesized that primary process expression on Gottschalk's Five Minute Verbalization Task (FMV) would be more representative of clinical status in schizophrenia than primary process expression on the Rorschach. Ss were 21 males and 15 females, ages 19-41 years, newly admitted to the hospital and treated with p... | Changes in primary process expression in hospitalized schizophrenics treated with phenothiazines: two projective tasks compared. It was hypothesized that primary process expression on Gottschalk's Five Minute Verbalization Task (FMV) would be more representative of clinical status in schizophrenia than primary process ... | [
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PMID:16083 | Effect of curare on responses to different putative neurotransmitters in Aplysia neurons. | We have studied the effects of curare on responses resulting from iontophoretic application of several putative neurotransmitters onto Aplysia neurons. These neurons have specific receptors for acetylcholine (ACh), dopamine, octopamine, phenylethanolamine, histamine, gamma-aminobutyric acid (GABA), aspartic acid, and g... | Effect of curare on responses to different putative neurotransmitters in Aplysia neurons. We have studied the effects of curare on responses resulting from iontophoretic application of several putative neurotransmitters onto Aplysia neurons. These neurons have specific receptors for acetylcholine (ACh), dopamine, octop... | [
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PMID:16091 | Role of the posterior hypothalamus in the development of acute brain swelling. | Destructive stereotaxic lesions were made in the posterior hypothalamus, unilaterally or bilaterally, in 26 dogs. In 21 dogs the intracranial pressure (ICP) was maintained in normal range, and in five dogs the ICP was artificially elevated to 300 to 400 mm h2o, preceding the procedures to the hypothlamus. Arterial oxyg... | Role of the posterior hypothalamus in the development of acute brain swelling. Destructive stereotaxic lesions were made in the posterior hypothalamus, unilaterally or bilaterally, in 26 dogs. In 21 dogs the intracranial pressure (ICP) was maintained in normal range, and in five dogs the ICP was artificially elevated t... | [
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PMID:16092 | Studies on the labeling of streptokinase with 99mTc for use as a radiopharmaceutical in the detection of deep-vein thrombosis: concise communication. | Streptokinase was labeled with 99mTc using both stannous chloride and stannous pyrophosphate as reducing agents. Sixty to seventy-five percent of the 99m Tc was incorporated into streptokinase using stannous chloride as a reducing agent at pH 1-2, wheras 50-60% was incorporated using stannous pyrophosphate at neutral p... | Studies on the labeling of streptokinase with 99mTc for use as a radiopharmaceutical in the detection of deep-vein thrombosis: concise communication. Streptokinase was labeled with 99mTc using both stannous chloride and stannous pyrophosphate as reducing agents. Sixty to seventy-five percent of the 99m Tc was incorpora... | [
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PMID:16099 | Integration of clinical and academic nursing at the hospital clinical unit level. | In a successful attempt to solve problems in Pediatric Nursing at the Medical University of South Carolina, a Department Chairman was named Director-Chairman of Pediatric Nursing and given operational authority over both clinical and academic nursing in Pediatrics. The results were more efficient administration, a high... | Integration of clinical and academic nursing at the hospital clinical unit level. In a successful attempt to solve problems in Pediatric Nursing at the Medical University of South Carolina, a Department Chairman was named Director-Chairman of Pediatric Nursing and given operational authority over both clinical and acad... | [
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PMID:16100 | Effect of dietary DL-ethionine and/or DL-methionine on egg laying and activities of some cytoplasmic NAD linked-dehydrogenases and NADPH-producing enzymes in liver of Japanese quail, Coturnix coturnix japonica. | The effect of dietary DL-ethionine and/or DL-methionine on egg laying, and activities of some NAD linked-dehydrogenases and NADPH-producing enzymes in liver of Japanese quail, Coturnix coturnix japonica was investigated. A 0.30% DL-ethionine plus 0.30% DL-methionine supplemented diet reversed partially the egg laying i... | Effect of dietary DL-ethionine and/or DL-methionine on egg laying and activities of some cytoplasmic NAD linked-dehydrogenases and NADPH-producing enzymes in liver of Japanese quail, Coturnix coturnix japonica. The effect of dietary DL-ethionine and/or DL-methionine on egg laying, and activities of some NAD linked-dehy... | [
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PMID:16101 | Stimulation of neutral amino acid transport by fructose in epithelial cells isolated from rat intestine. | Interest in the nutritional and physiological implications of the high dietary intakes of fructose from sucrose and isomerized corn sweeteners has directed attention to the specific metabolic properties of this monosaccharide. Epithelial cells isolated from the small intestine of Wistar rats fed a stock diet showed 24... | Stimulation of neutral amino acid transport by fructose in epithelial cells isolated from rat intestine. Interest in the nutritional and physiological implications of the high dietary intakes of fructose from sucrose and isomerized corn sweeteners has directed attention to the specific metabolic properties of this mono... | [
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PMID:16102 | Influence of dietary lipid on lipogenic enzyme activities in coho salmon, Oncorhynchus kisutch (Walbaum). | Coho salmon (Oncorhynchus kisutch), 8 to 18 months of age, were maintained in culture tanks and were fed three semipurified diets. The diets contained 40% of energy from protein and 11.5%, 23%, or 46% of energy from lipid. The body weight gain and food conversion factors were similar among groups of fish fed the diets ... | Influence of dietary lipid on lipogenic enzyme activities in coho salmon, Oncorhynchus kisutch (Walbaum). Coho salmon (Oncorhynchus kisutch), 8 to 18 months of age, were maintained in culture tanks and were fed three semipurified diets. The diets contained 40% of energy from protein and 11.5%, 23%, or 46% of energy fro... | [
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PMID:16103 | The immediate nucleotide precursor, guanosine triphosphate, in the riboflavin biosynthetic pathway. | In the present paper, the nucleotide precursor of riboflavin was investigated by experiments with labeled purines using non-growing cells of Eremothecium ashybii. The added purines, at 10(-4) M, were effectively incorporated into riboflavin at an early stage of riboflavin biosynthesis under the experimental conditions.... | The immediate nucleotide precursor, guanosine triphosphate, in the riboflavin biosynthetic pathway. In the present paper, the nucleotide precursor of riboflavin was investigated by experiments with labeled purines using non-growing cells of Eremothecium ashybii. The added purines, at 10(-4) M, were effectively incorpor... | [
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PMID:16104 | Reconstitution of T-cell function in severe combined immunodeficiency disease following transplantation of early embryonic liver cells. | In a 51/2-month-old male infant with adenosine deaminase-positive severe combined immunodeficiency disease, who had no suitable bone marrow donor, immunologic reconstitution was attempted with lymphoid cells obtained from the liver of a 4- to 5-week-old-male human embryo. A mild graft-versus-host reaction began three w... | Reconstitution of T-cell function in severe combined immunodeficiency disease following transplantation of early embryonic liver cells. In a 51/2-month-old male infant with adenosine deaminase-positive severe combined immunodeficiency disease, who had no suitable bone marrow donor, immunologic reconstitution was attemp... | [
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PMID:16105 | Peritoneal dialysis for severe methyprylon intoxication. | The appropriate therapy for methyprylon (Noludar) poisoning has remained controversial, owing to a lack of reliable pharmacologic data concerning the most effective way to remove the drug after a large ingestion. We recently employed peritoneal dialysis to treat a 16-year-old girl, who had ingested 6.3 gm of methypyrlo... | Peritoneal dialysis for severe methyprylon intoxication. The appropriate therapy for methyprylon (Noludar) poisoning has remained controversial, owing to a lack of reliable pharmacologic data concerning the most effective way to remove the drug after a large ingestion. We recently employed peritoneal dialysis to treat ... | [
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PMID:16106 | Development of Haemonchus contortus in vitro and the stimulus from the host. | Infective larvae of Haemonchus contortus which have been exposed for about 9 hr to relatively high partial pressures of carbon dioxide at near-neutral pH, as they might be in the rumen, develop slowly to the fourth stage or not at all. But following this treatment, exposure to lower partial pressures of carbon dioxide ... | Development of Haemonchus contortus in vitro and the stimulus from the host. Infective larvae of Haemonchus contortus which have been exposed for about 9 hr to relatively high partial pressures of carbon dioxide at near-neutral pH, as they might be in the rumen, develop slowly to the fourth stage or not at all. But fol... | [
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PMID:16111 | In vitro adsortpion of acetaminophen onto activated charcoal. | In vitro experiments supported in vivo evidence that activated charcoal is effective in adsorbing acetaminophen. In the physiologic pH range, adsorption was rapid and pH independent. Adsorption, however, was dependent upon the quantity of activated charcoal employed, becoming more complete as the quantity of activated ... | In vitro adsortpion of acetaminophen onto activated charcoal. In vitro experiments supported in vivo evidence that activated charcoal is effective in adsorbing acetaminophen. In the physiologic pH range, adsorption was rapid and pH independent. Adsorption, however, was dependent upon the quantity of activated charcoal ... | [
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PMID:16112 | Conformational studies of antiradiation agents by NMR: cysteamine and its derivatives. | The conformations of cysteamine, thiazolidine, and thiazolidine-4-carboxylic acid were determined in aqueous solutions using NMR spectroscopy. At physiological pH, the population ratio of gauche- and trans-conformers was 3:1. The gauche-rotamer is probably responsible for the antiradiation activity and acts through met... | Conformational studies of antiradiation agents by NMR: cysteamine and its derivatives. The conformations of cysteamine, thiazolidine, and thiazolidine-4-carboxylic acid were determined in aqueous solutions using NMR spectroscopy. At physiological pH, the population ratio of gauche- and trans-conformers was 3:1. The gau... | [
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PMID:16113 | Solubility studies of silver sulfadiazine. | The solubility of silver sulfadiazine as a function of pH was determined in nitric acid-potassium nitrate buffer for pH 2-3 and in 2-(N-morpholino)ethanesulfonic acid buffer for pH 6-7. As the salt of a weak organic acid, silver sulfadiazine exhibits the anticipated increase in solubility with an increasing hydrogen-io... | Solubility studies of silver sulfadiazine. The solubility of silver sulfadiazine as a function of pH was determined in nitric acid-potassium nitrate buffer for pH 2-3 and in 2-(N-morpholino)ethanesulfonic acid buffer for pH 6-7. As the salt of a weak organic acid, silver sulfadiazine exhibits the anticipated increase i... | [
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PMID:16114 | Metal-ion interaction with penicillins: kinetics of complexation of nickel(II). | The kinetics of complexation of nickel(II) with some penicillins and related compounds show that the zwitterionic form of the ligand has very low reactivity compared to the anionic form. The resolved rate constants are interpreted in terms of binding to the ring nitrogen and carboxyl group and not to the side chain. | Metal-ion interaction with penicillins: kinetics of complexation of nickel(II). The kinetics of complexation of nickel(II) with some penicillins and related compounds show that the zwitterionic form of the ligand has very low reactivity compared to the anionic form. The resolved rate constants are interpreted in terms ... | [
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PMID:16116 | Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines II: oxazepam and diazepam. | The hydrolysis kinetics of oxazepam and diazepam leading to a benzophenone product and a glycine derivative were quantified from pH 1 to 11. For oxazepam, two intermediates were isolated and identified, indicating a parallel consecutive reaction mechanism. The hydrolysis occurred uncatalyzed and demonstrated acid-base ... | Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines II: oxazepam and diazepam. The hydrolysis kinetics of oxazepam and diazepam leading to a benzophenone product and a glycine derivative were quantified from pH 1 to 11. For oxazepam, two intermediates were isolated and identified, indicating a parallel consecu... | [
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PMID:16115 | Mechanism of histamine binding II: effect of alkali metal and alkaline earth cations on histamine binding to peptide H. | The association constants of histamine with Mg2+, Ca2+, Sr2+, and Ba2+ were determined in buffer solutions at constant pH using an ion selective electrode. These cations enabled histamine to bind to peptide H. A minimum cation binding concentration was required for histamine binding. A linear relationship existed betwe... | Mechanism of histamine binding II: effect of alkali metal and alkaline earth cations on histamine binding to peptide H. The association constants of histamine with Mg2+, Ca2+, Sr2+, and Ba2+ were determined in buffer solutions at constant pH using an ion selective electrode. These cations enabled histamine to bind to p... | [
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PMID:16117 | Motor innervation of the smooth muscle of the rat seminal vesicle. | Frequency-related isovolumetric contractions of the rat seminal vesicle elicited with transmural electrical stimulation were blocked by tetrodotoxin but unaffected by hexamethonium. The postganglionic motor innervation of the rat seminal vesicle is purely excitatory and contains both an adrenergic and a cholinergic com... | Motor innervation of the smooth muscle of the rat seminal vesicle. Frequency-related isovolumetric contractions of the rat seminal vesicle elicited with transmural electrical stimulation were blocked by tetrodotoxin but unaffected by hexamethonium. The postganglionic motor innervation of the rat seminal vesicle is pure... | [
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PMID:16118 | Organ culture of rat superior cervical ganglia. | The maintenance of adrenergic function has been investigated in organ cultures of adult rat superior cervical ganglia. Tyrosine hydroxylase and monoamine oxidase activities decreased gradually through 72 hours of culture. Dopamine beta-hydroxylase activity gradually increased in the cultured ganglia to 150% of that see... | Organ culture of rat superior cervical ganglia. The maintenance of adrenergic function has been investigated in organ cultures of adult rat superior cervical ganglia. Tyrosine hydroxylase and monoamine oxidase activities decreased gradually through 72 hours of culture. Dopamine beta-hydroxylase activity gradually incre... | [
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PMID:16119 | Effects of ethosuximide on transmission of repetitive impulses and apparent rates of transmitter turnover in the spinal monosynaptic pathway. | The effects of ethosuximide on spinal monosynaptic transmission were studied in cats. The drug in doses of 200 or 400 mg/kg deepened the decline of monosynaptic response amplitude evoked by trains of 10 stimuli to a motor nerve at 2, 5 or 10 Hz, without affecting the transmission of single isolated impulses. The patter... | Effects of ethosuximide on transmission of repetitive impulses and apparent rates of transmitter turnover in the spinal monosynaptic pathway. The effects of ethosuximide on spinal monosynaptic transmission were studied in cats. The drug in doses of 200 or 400 mg/kg deepened the decline of monosynaptic response amplitud... | [
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PMID:16120 | The binding of strychnine and strychnine analogs to synaptic membranes of rat brainstem and spinal cord. | Crude synaptic membranes were isolated from rat pons, medulla and spinal cord by differential centrifugation. The specific binding of [3H]strychnine, obtained by subtracting from the bound radioactivity the amount not displaced by 50 micronm unlabeled strychnine, was saturable with a KD value of 12 nM. The dissociation... | The binding of strychnine and strychnine analogs to synaptic membranes of rat brainstem and spinal cord. Crude synaptic membranes were isolated from rat pons, medulla and spinal cord by differential centrifugation. The specific binding of [3H]strychnine, obtained by subtracting from the bound radioactivity the amount n... | [
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PMID:16121 | Serotonin and dopamine as neurotransmitters in mytilus: block of serotonin receptors by an organic mercurial. | The effects of mersalyl, bromo-LSD (BOL) and methysergide (UML) on the relaxation of catch by certain indole and catechol derivatives were studied in the anterior byssus retractor muscle of Mytilus. Mersalyl antagonized relaxation in response to serotonin whereas BOL and UML were less effective. Two other indole deriva... | Serotonin and dopamine as neurotransmitters in mytilus: block of serotonin receptors by an organic mercurial. The effects of mersalyl, bromo-LSD (BOL) and methysergide (UML) on the relaxation of catch by certain indole and catechol derivatives were studied in the anterior byssus retractor muscle of Mytilus. Mersalyl an... | [
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PMID:16122 | Specific enhancement of norepinephrine-induced contraction in rat veins after beta adrenergic antagonists. | Propranolol markedly increased the norepinephrine-induced maximal force in circular smooth muscle of the rat portal, mesenteric, renal and, to a lesser extent, femoral veins without affecting aortic or mesenteric artery responses to norepinephrine. Furthermore, two other beta receptor antagonists, practolol and N-isopr... | Specific enhancement of norepinephrine-induced contraction in rat veins after beta adrenergic antagonists. Propranolol markedly increased the norepinephrine-induced maximal force in circular smooth muscle of the rat portal, mesenteric, renal and, to a lesser extent, femoral veins without affecting aortic or mesenteric ... | [
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PMID:16123 | Urinary carbon dioxide tension in lithium carbonate-treated patients. | Renal acidification was studied in 12 lithium carbonate-treated psychiatric patients. The urinary Pco2 response to oral sodium bicarbonate loading, a qualitative index of distal hydrogen ion secretion, was evaluated in all patients and the results were compared with those obtained in 10 control subjects. The average ma... | Urinary carbon dioxide tension in lithium carbonate-treated patients. Renal acidification was studied in 12 lithium carbonate-treated psychiatric patients. The urinary Pco2 response to oral sodium bicarbonate loading, a qualitative index of distal hydrogen ion secretion, was evaluated in all patients and the results we... | [
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PMID:16124 | The development of some metabolic responses to hypoxia in the foetal sheep. | 1. Foetal and maternal plasma metabolite and catecholamine concentrations have been measured in chronically catheterized sheep, 95-145 days pregnant. 2. With increasing gestational age there was rise in foetal plasma lactate, free fatty acid and ketone body concentration and in maternal plasma in free fatty acid and ke... | The development of some metabolic responses to hypoxia in the foetal sheep. 1. Foetal and maternal plasma metabolite and catecholamine concentrations have been measured in chronically catheterized sheep, 95-145 days pregnant. 2. With increasing gestational age there was rise in foetal plasma lactate, free fatty acid an... | [
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PMID:16125 | Possible explanations for the differences in secretory characteristics between conjugated and free bile acids. | 1. The hepatic extraction fraction and maximum excretory rate of conjugated cholate are greater than those of free cholate (studied after acute taurine depletion); the possibility that this difference might be due to greater bile-to-blood back-diffusion of un-ionized cholic acid (pKa 5-5) compared to that of taurocholi... | Possible explanations for the differences in secretory characteristics between conjugated and free bile acids. 1. The hepatic extraction fraction and maximum excretory rate of conjugated cholate are greater than those of free cholate (studied after acute taurine depletion); the possibility that this difference might be... | [
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PMID:16126 | The effect of calcium injection on the intracellular sodium and pH of snail neurones. | 1. Ion-sensitive glass micro-electrodes were used to measure the intracellular pH (pHi) and the intracellular sodium ion concentration, [Na+]i, in identified Helix aspersa neurones. 2. The injection of small volumes of 0-1 McaCl2, which increased the membrane potential by 10-15 mV for 1-2 min, had little or no effect o... | The effect of calcium injection on the intracellular sodium and pH of snail neurones. 1. Ion-sensitive glass micro-electrodes were used to measure the intracellular pH (pHi) and the intracellular sodium ion concentration, [Na+]i, in identified Helix aspersa neurones. 2. The injection of small volumes of 0-1 McaCl2, whi... | [
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PMID:16129 | Facilitation of transmitter secretion from toad motor nerve terminals during brief trains of action potentials. | 1. End-plate potentials produced by brief trains of action potentials (5-7 at 50-100 Hz) were recorded at toad sciatic-sartorius neuromuscular junctions. When transmitter secretion was depressed in solutions containing magnesium, the increase in amplitude (growth pattern) of successive end-plate-potentials was greater ... | Facilitation of transmitter secretion from toad motor nerve terminals during brief trains of action potentials. 1. End-plate potentials produced by brief trains of action potentials (5-7 at 50-100 Hz) were recorded at toad sciatic-sartorius neuromuscular junctions. When transmitter secretion was depressed in solutions ... | [
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PMID:16128 | Extracellular potassium and trasmitter release at the giant synapse of squid. | 1. The effects of changes in extracellular K concentration, [K]0, on synaptic transmission were studied at the squid giant synapse with intracellular recording from the presynaptic terminal and post-synaptic axon. 2. The amplitudes of both the presynaptic spike and the e.p.s.p. varied inversely with [K]0. On the averag... | Extracellular potassium and trasmitter release at the giant synapse of squid. 1. The effects of changes in extracellular K concentration, [K]0, on synaptic transmission were studied at the squid giant synapse with intracellular recording from the presynaptic terminal and post-synaptic axon. 2. The amplitudes of both th... | [
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PMID:16130 | [Arteriographic appearances seen in the course of development of the lesions of polyarteritis nodosa (author's transl)]. | Three cases of polyarteritis nodosa (P.A.N.) studied by abdominal arteriography with a follow-up examination between the 6th and 9th month are reported. In the first case, the initial arteriogram showed only the appearances of endarteritis. The second arteriogram, 9 months later, following a worsening of general condit... | [Arteriographic appearances seen in the course of development of the lesions of polyarteritis nodosa (author's transl)]. Three cases of polyarteritis nodosa (P.A.N.) studied by abdominal arteriography with a follow-up examination between the 6th and 9th month are reported. In the first case, the initial arteriogram sho... | [
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PMID:16131 | The role of the urologist in barren marriages. | This paper is addressed to the gynecologist, who is generally the first to be consulted by the patient because of her failure to conceive. Early in the study there arises the problem of assigning individual factors. Is the patient involved solely, or is there also a male factor? Excluding the female's role to bear and ... | The role of the urologist in barren marriages. This paper is addressed to the gynecologist, who is generally the first to be consulted by the patient because of her failure to conceive. Early in the study there arises the problem of assigning individual factors. Is the patient involved solely, or is there also a male f... | [
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PMID:16132 | Synthesis and biological activity of some vinyl-substituted 2-nitroimidazoles. | In previous studies 1-methyl-2-nitro-1H-imidazole-5-carboxaldehyde and 1-methyl-2-nitro-5-vinyl-1H-imidazole were found to posses interesting antimicrobial activities. We have now prepared some 2-nitro-1H-imidazoles in which the 5-vinyl chain bears selected functional groups (CHO, COCH3, NO2) as well as nitrogen-conden... | Synthesis and biological activity of some vinyl-substituted 2-nitroimidazoles. In previous studies 1-methyl-2-nitro-1H-imidazole-5-carboxaldehyde and 1-methyl-2-nitro-5-vinyl-1H-imidazole were found to posses interesting antimicrobial activities. We have now prepared some 2-nitro-1H-imidazoles in which the 5-vinyl chai... | [
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PMID:16133 | N-(2,4,5-Trihydroxyphenehtyl)normetazocine, a potential irreversible inhibitor of the narcotic receptor. | The reaction of N-2,4,5-tribenzyloxyphenyl)ethyl methanesulfonate, prepared in a seven-step sequence, with normetazocine followed by hydrogenolysis of the benzyloxy-protecting groups, gave N-(2,4,5-trihydroxyphenethyl)normetazocine. This compound was prepared to study the effect of a narcotic analgesic containing a fun... | N-(2,4,5-Trihydroxyphenehtyl)normetazocine, a potential irreversible inhibitor of the narcotic receptor. The reaction of N-2,4,5-tribenzyloxyphenyl)ethyl methanesulfonate, prepared in a seven-step sequence, with normetazocine followed by hydrogenolysis of the benzyloxy-protecting groups, gave N-(2,4,5-trihydroxypheneth... | [
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PMID:16134 | 5-allyl-9-oxobenzomorphans. 3. Potent narcotic antagonists and analgesics-antagonists in the series of substituted 2',9beta-dihydroxy-6,7-benzomorphans. | 5-Allyl-2'-methoxy-2-methyl-9-oxo-6,7-benzomorphan methiodide (1) has been converted in a selective two-step process to the corresponding 9beta-hydroxy intermediates 4 and 6, which in turn were transformed via modified von Braun demethylation-acylation to the amides 11 and 21, respectively. These were reduced and demet... | 5-allyl-9-oxobenzomorphans. 3. Potent narcotic antagonists and analgesics-antagonists in the series of substituted 2',9beta-dihydroxy-6,7-benzomorphans. 5-Allyl-2'-methoxy-2-methyl-9-oxo-6,7-benzomorphan methiodide (1) has been converted in a selective two-step process to the corresponding 9beta-hydroxy intermediates 4... | [
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PMID:16135 | Synthesis and narcotic agonist-antagonist evaluation of some 2,6-methano-3-benzazocine-11 propanols. Analogues of the ring C bridged oripavine-7-mehtanols. | A general synthesis of variously substituted 2,6-methano-3-benzazocine-11-propanols is described. Nine N-CH3 derivatives and their corresponding N-cyclopropylmethyl counterparts were prepared and studied in the mouse acetylcholine induced writhing and rat phenazocine antagonism tests. The results are compared with lite... | Synthesis and narcotic agonist-antagonist evaluation of some 2,6-methano-3-benzazocine-11 propanols. Analogues of the ring C bridged oripavine-7-mehtanols. A general synthesis of variously substituted 2,6-methano-3-benzazocine-11-propanols is described. Nine N-CH3 derivatives and their corresponding N-cyclopropylmethyl... | [
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PMID:16136 | Adrenergic agents. 4. Substituted phenoxypropanolamine derivatives as potential beta-adrenergic agonists. | A series of 1-(substituted phenoxy)-3-(tert-butylamino)-2-propanols in which the ring substituents were 3,4-dihydroxy (6f), 3- and 4-hydroxy (6g and 6h, respectively), 3-hydroxy-4-methylsulfonamido (6i), its 3,4-transposed isomer (6j), and 4-methylsulfonylmethyl (6k) was prepared and examined for beta-adrenergic agonis... | Adrenergic agents. 4. Substituted phenoxypropanolamine derivatives as potential beta-adrenergic agonists. A series of 1-(substituted phenoxy)-3-(tert-butylamino)-2-propanols in which the ring substituents were 3,4-dihydroxy (6f), 3- and 4-hydroxy (6g and 6h, respectively), 3-hydroxy-4-methylsulfonamido (6i), its 3,4-tr... | [
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PMID:16138 | Plasmalemma transport of OH- in Chara corallina: dynamics of activation and deactivation. | The light-mediated, time-dependent rise in the pH value at the center of an alkaline band was analyzed using the methods of numerical analysis. From this analysis an expression of the time-dependent build-up of OH- efflux was obtained for these bands. This information can now be employed to determine whether the light-... | Plasmalemma transport of OH- in Chara corallina: dynamics of activation and deactivation. The light-mediated, time-dependent rise in the pH value at the center of an alkaline band was analyzed using the methods of numerical analysis. From this analysis an expression of the time-dependent build-up of OH- efflux was obta... | [
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PMID:16141 | Growth of a heterologous tumor cell line in neonatal rats with graft-versus-host disease. | The ability of a hamster tumor cell line (T20) to grow and exhibit type H virus particles was significantly enhanced in neonatal DA rats with graft-versus-host disease (GVHD). Tumor growth peaked on days 4 and 7 in control littermates receiving adult syngeneic cells or no cells at birth, respectively, and then subseque... | Growth of a heterologous tumor cell line in neonatal rats with graft-versus-host disease. The ability of a hamster tumor cell line (T20) to grow and exhibit type H virus particles was significantly enhanced in neonatal DA rats with graft-versus-host disease (GVHD). Tumor growth peaked on days 4 and 7 in control litterm... | [
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PMID:16142 | Carcinoma in situ of the ectopic testis. | A young man with a palpable ectopic testis underwent right testis biopsy and orchiopexy. Since histological findings of the biopsy specimen revealed an unsuspected intratubular carcinoma in situ and evidence of diminished spermatogenic potential, an inguinal orchiectomy was done. This appears to be the first reported c... | Carcinoma in situ of the ectopic testis. A young man with a palpable ectopic testis underwent right testis biopsy and orchiopexy. Since histological findings of the biopsy specimen revealed an unsuspected intratubular carcinoma in situ and evidence of diminished spermatogenic potential, an inguinal orchiectomy was done... | [
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PMID:16143 | Childhood gonadoblastoma and seminoma in a dysgenetic cryptorchid gonad. | A case of gonadoblastoma and seminoma occurring in a genotypic male child with ambiguous genitalia is presented. A review of the literature establishes that children with intersex disorders who possess a Y chromosome and undescended gonads stand a particularly high risk of having this type of gonadal neoplasm and shoul... | Childhood gonadoblastoma and seminoma in a dysgenetic cryptorchid gonad. A case of gonadoblastoma and seminoma occurring in a genotypic male child with ambiguous genitalia is presented. A review of the literature establishes that children with intersex disorders who possess a Y chromosome and undescended gonads stand a... | [
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PMID:16144 | Acute bacteremia in asplenic renal transplant patients. | Four cases of overwhelming bacteremia were observed in asplenic renal transplant patients 12 to 20 months after transplantation. The bacteriologic findings and presentation of these infections are characteristic of post-splenectomy sepsis reported in nontransplant patients. It is suggested that the absence of the splee... | Acute bacteremia in asplenic renal transplant patients. Four cases of overwhelming bacteremia were observed in asplenic renal transplant patients 12 to 20 months after transplantation. The bacteriologic findings and presentation of these infections are characteristic of post-splenectomy sepsis reported in nontransplant... | [
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PMID:16145 | Prune-belly syndrome in a 54-year-old man. | A 54-year-old man was diagnosed as having prune-belly syndrome, a deficiency of abdominal musculature, cryptorchidism, abnormalities of the urinary tract, and chronic renal failure. The patient was asymptomatic until the diagnosis was made at the age of 54 years; he is one of the oldest living patients to be reported i... | Prune-belly syndrome in a 54-year-old man. A 54-year-old man was diagnosed as having prune-belly syndrome, a deficiency of abdominal musculature, cryptorchidism, abnormalities of the urinary tract, and chronic renal failure. The patient was asymptomatic until the diagnosis was made at the age of 54 years; he is one of ... | [
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PMID:16149 | Antibiotic susceptibility of Streptococcus pneumoniae isolated from clinical materials (author's transl). | We tested the drug-susceptibility of 112 strains of Streptococcus pneumoniae isolated from various clinical materials since January 1975 to May 1976, and observed the changes of susceptibility of this pathogen. All strains tested remained very sensitive to benzylpenicillin and cephaloridine, but 59.8% of strains were r... | Antibiotic susceptibility of Streptococcus pneumoniae isolated from clinical materials (author's transl). We tested the drug-susceptibility of 112 strains of Streptococcus pneumoniae isolated from various clinical materials since January 1975 to May 1976, and observed the changes of susceptibility of this pathogen. All... | [
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PMID:16151 | T cell function detected in murine bone marrow cells. | Mouse bone marrow cells were fractionated by BSA discontinuous density gradient centrifugation, and a small lymphocyte rich fraction was obtained at the high density. Cells of this fraction were shown to respond in vitro to T cell mitogens and alloantigens. Furthermore, they were able to mount a graft-versus-host react... | T cell function detected in murine bone marrow cells. Mouse bone marrow cells were fractionated by BSA discontinuous density gradient centrifugation, and a small lymphocyte rich fraction was obtained at the high density. Cells of this fraction were shown to respond in vitro to T cell mitogens and alloantigens. Furtherm... | [
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PMID:16152 | Physicochemical properties of a liquid ion exchanger microelectrode and its application to biological fluids. | Double-barreled potassium or chloride ion-selective microelectrodes were constructed using a liquid ion exchanger. Technical details of the fabrication of double-barreled microelectrodes, having a PD sensor as one barrel and an ionic sensor as the other, are described. The sensitivity of K+ or CI- ion-selective microel... | Physicochemical properties of a liquid ion exchanger microelectrode and its application to biological fluids. Double-barreled potassium or chloride ion-selective microelectrodes were constructed using a liquid ion exchanger. Technical details of the fabrication of double-barreled microelectrodes, having a PD sensor as ... | [
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PMID:16153 | Effects of intracellular pH on plateau formation following the action potential of squid giant axons. | When squid giant axons were intracellularly perfused for about 10 min with 100 mM K+ solutions containing Pronase or Protease Type VII at a concentration of 0.1-0.5 mg/ml, the action potential developed a long-lasting plateau. The plateau persisted after switching to an enzyme-free solution at standard pH (7.3 +/- 0.1)... | Effects of intracellular pH on plateau formation following the action potential of squid giant axons. When squid giant axons were intracellularly perfused for about 10 min with 100 mM K+ solutions containing Pronase or Protease Type VII at a concentration of 0.1-0.5 mg/ml, the action potential developed a long-lasting ... | [
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PMID:16154 | Effects of sodium bicarbonate administration during cardiopulmonary resuscitation. | To study whether sodium bicarbonate given in cardiopulmonary resuscitation may produce life-threatening hyperosmolality or hypernatremia, arterial blood was analysed for blood gas, alcohol, blood urea nitrogen, electrolyte and osmolality. The blood was drawn after resuscitation in successful cases, and while effective ... | Effects of sodium bicarbonate administration during cardiopulmonary resuscitation. To study whether sodium bicarbonate given in cardiopulmonary resuscitation may produce life-threatening hyperosmolality or hypernatremia, arterial blood was analysed for blood gas, alcohol, blood urea nitrogen, electrolyte and osmolality... | [
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PMID:16155 | Cryptorchidism and abdominal pain. | In this case report, abdominal symptoms simulating acute appendicitis were due to recurrent torsion of an intra-abdominal testicle. Cryptorchidism frequently goes unnoted. Most undescended testicles are in the groin and easily palpable. If not, they can be absent, retroperitoneal or intra-abdominal. An intra-abdominal ... | Cryptorchidism and abdominal pain. In this case report, abdominal symptoms simulating acute appendicitis were due to recurrent torsion of an intra-abdominal testicle. Cryptorchidism frequently goes unnoted. Most undescended testicles are in the groin and easily palpable. If not, they can be absent, retroperitoneal or i... | [
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PMID:16156 | Acid-base relationships in the different body compartments: the basis for a simplified diagnostic approach. | Special characteristics of cellular buffering must be taken into account in order to describe accurately acid-base relationships in the whole body. In particular, tissues other than blood are able to neutralize mineral acid independent of changes in Pco(2) and hence independent of large changes in extra- and intracellu... | Acid-base relationships in the different body compartments: the basis for a simplified diagnostic approach. Special characteristics of cellular buffering must be taken into account in order to describe accurately acid-base relationships in the whole body. In particular, tissues other than blood are able to neutralize m... | [
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PMID:16157 | [Use of coronaroactive agents with beta-stimulating effect in ischemic heart disease]. | In feline experiments and 65 clinical cases of ischaemic heart disease the efficacy of a new beta-stimulating agetn -- Ildamen -- was studied, the obtained effect was compared to that of Euphillin. Ildamen was found to be highly effective in patients with a moderately decreased coronary reserve and without atherosclero... | [Use of coronaroactive agents with beta-stimulating effect in ischemic heart disease]. In feline experiments and 65 clinical cases of ischaemic heart disease the efficacy of a new beta-stimulating agetn -- Ildamen -- was studied, the obtained effect was compared to that of Euphillin. Ildamen was found to be highly effe... | [
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PMID:16160 | Acidifying defect induced by amphotericin B: comparison of bicarbonate and hydrogen ion permeabilities. | The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence o... | Acidifying defect induced by amphotericin B: comparison of bicarbonate and hydrogen ion permeabilities. The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absen... | [
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PMID:16171 | [The role of proximal osteomy of the tibia in the treatment of arthrosis of the knee joint]. | The results of heigh tibia osteotomy performed between 1970 and 1975 in 20 cases in the material of the Orthopaedic Department of the "Semmelweis" University Medical School, Budapest, are reported. In 13 cases good--in 6 cases satisfactory results have been obtained. In 1 case the surgical intervention was of no effect... | [The role of proximal osteomy of the tibia in the treatment of arthrosis of the knee joint]. The results of heigh tibia osteotomy performed between 1970 and 1975 in 20 cases in the material of the Orthopaedic Department of the "Semmelweis" University Medical School, Budapest, are reported. In 13 cases good--in 6 cases ... | [
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PMID:16172 | [Restoration problems in frontoglabellar skull defects]. | Replacement problems of frontoglabellar skull defects and their recent operative methods come under review. A new method for the prevention of infection of paranasal sinus origin is reported in the article. Possibilities for producing good contour frontal area prothesis are considered here. The new method developed by ... | [Restoration problems in frontoglabellar skull defects]. Replacement problems of frontoglabellar skull defects and their recent operative methods come under review. A new method for the prevention of infection of paranasal sinus origin is reported in the article. Possibilities for producing good contour frontal area pr... | [
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PMID:16173 | [Post-traumatic protrusion of the hip joint]. | 23 patients with post-traumatic protrusion of the hip joint--due to fracture of the base of the acetabulum--have been re-examined by the authors. On the basis of the radiomorphological alterations developed in consequence of the fracture and according to the severity of the articular deformation the cases have been cla... | [Post-traumatic protrusion of the hip joint]. 23 patients with post-traumatic protrusion of the hip joint--due to fracture of the base of the acetabulum--have been re-examined by the authors. On the basis of the radiomorphological alterations developed in consequence of the fracture and according to the severity of the... | [
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PMID:16174 | [Malignant degeneration of chronic suppurative bone diseases]. | Out of 1189 patients with osteomyelitis of the Hungarian Institute of Medical Rehabilitation malignant degeneration in the region of purulent bone process has been observed in 6 cases by the authors. Out of them 5 cases were carcinoma planocellulare and 1 case was sarcoma gigantocellulare. During the detailed analyses ... | [Malignant degeneration of chronic suppurative bone diseases]. Out of 1189 patients with osteomyelitis of the Hungarian Institute of Medical Rehabilitation malignant degeneration in the region of purulent bone process has been observed in 6 cases by the authors. Out of them 5 cases were carcinoma planocellulare and 1 c... | [
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PMID:16175 | [Ultrastructural changes in the skeletal muscles following nerve and tendon injuries in man. II. Nerve injuries]. | The alterations occuring in the fine structure of the man's hand muscles after traumatic nerve injuries have been examined by the authors. In the muscle portions taken in the 6th--16th weeks after the injury considerable atrophy of the contractile components, the desorganisation of the myofilaments, and the atropy of t... | [Ultrastructural changes in the skeletal muscles following nerve and tendon injuries in man. II. Nerve injuries]. The alterations occuring in the fine structure of the man's hand muscles after traumatic nerve injuries have been examined by the authors. In the muscle portions taken in the 6th--16th weeks after the injur... | [
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PMID:16176 | [Structure and configuration of human tendons. II. Development of tendon structure during ontogenesis]. | In infants born in the 24th--30th weeks of the gravidity the praenatal development and the process of the organization of the tendinous structure have been examined by the authors. By means of photo- and polarization microscopic examinations it was found that the tendon of the flexor hand muscles (M. flexor carpi radia... | [Structure and configuration of human tendons. II. Development of tendon structure during ontogenesis]. In infants born in the 24th--30th weeks of the gravidity the praenatal development and the process of the organization of the tendinous structure have been examined by the authors. By means of photo- and polarization... | [
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PMID:16177 | [Synovial chondrochromatosis of the metacarpophalangeal joint]. | A rare case of synovial chondromatosis sited on the IVth metacarpophalangeal articulation of the left hand of a women is reported. The pathogenesis, the histology and the method of treatment are discussed. 2 years after the operation the patient is symptom-free and without complaints. | [Synovial chondrochromatosis of the metacarpophalangeal joint]. A rare case of synovial chondromatosis sited on the IVth metacarpophalangeal articulation of the left hand of a women is reported. The pathogenesis, the histology and the method of treatment are discussed. 2 years after the operation the patient is symptom... | [
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PMID:16178 | [Oto-palato-digital (Taybi) syndrome]. | A case of dysmorphogenetic syndrome, described by Taybi, is reported. The syndrome is characterized by hardness of hearing of conduction type, submucous cleft palate and anomalies involving the bony frame, especially the digits. | [Oto-palato-digital (Taybi) syndrome]. A case of dysmorphogenetic syndrome, described by Taybi, is reported. The syndrome is characterized by hardness of hearing of conduction type, submucous cleft palate and anomalies involving the bony frame, especially the digits. | [
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PMID:16179 | [Luxation fracture of the hip joint. I. Posterior fractures with dislocation]. | 41 cases of posterior sprain fracture are analysed by the authors. 4--10 years after the injury 31 patients appeared at the check-inspection. On the basis of the late results it is stated by the authors that the immediate diagnosis and the reposition of the luxation are of the greatest importance. Conservative treatmen... | [Luxation fracture of the hip joint. I. Posterior fractures with dislocation]. 41 cases of posterior sprain fracture are analysed by the authors. 4--10 years after the injury 31 patients appeared at the check-inspection. On the basis of the late results it is stated by the authors that the immediate diagnosis and the r... | [
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PMID:16180 | [Local soft tissue ossification of traumatic origin]. | Under the effect of trauma, in 4 patients the development of metaplastic bone-tissue in the soft-parts of mesenchymal origin has been observed by the author. In 3 patients the development of supernumerary articulations proved the appearance of cartilaginous tissue; in consequence, the presence of cartilaginous tissue m... | [Local soft tissue ossification of traumatic origin]. Under the effect of trauma, in 4 patients the development of metaplastic bone-tissue in the soft-parts of mesenchymal origin has been observed by the author. In 3 patients the development of supernumerary articulations proved the appearance of cartilaginous tissue; ... | [
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PMID:16184 | A systems analysis of the impact of physician extenders on medical cost and manpower requirements. | This paper presents a descriptive narrative of a mathematical manpower model and the results of an analysis of the effect physician extenders have on medical costs and manpower requirements. The model is extensively developed, through the use of a new medical classification system in the area of delegation of specific ... | A systems analysis of the impact of physician extenders on medical cost and manpower requirements. This paper presents a descriptive narrative of a mathematical manpower model and the results of an analysis of the effect physician extenders have on medical costs and manpower requirements. The model is extensively devel... | [
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PMID:16185 | Physician receptivity to nurse practitioners: a study of the correlates of the delegation of clinical responsibility. | A survey to measure physician receptivity to nurse practitioners was conducted in North Carolina in 1973. All North Carolina physicians were asked to rate a list of 35 clinical tasks of varying levels of difficulty and responsibility according to their willingness to delegate these tasks to nurse practitioners. Using e... | Physician receptivity to nurse practitioners: a study of the correlates of the delegation of clinical responsibility. A survey to measure physician receptivity to nurse practitioners was conducted in North Carolina in 1973. All North Carolina physicians were asked to rate a list of 35 clinical tasks of varying levels o... | [
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PMID:16191 | Comparative effects of (--)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. | (--)-Hydroxycitrate and (+)-allo-hydroxycitrate were investigated for their effects on lipid synthesis in vivo under conditions of either high carbohydrate feeding or 24 hr fasting. Changes in rates of lipid synthesis resulting from the oral administration of these compounds were monitored with the use of radiolabeled ... | Comparative effects of (--)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. (--)-Hydroxycitrate and (+)-allo-hydroxycitrate were investigated for their effects on lipid synthesis in vivo under conditions of either high carbohydrate feeding or 24 hr ... | [
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PMID:16194 | Fetal fuels. I. Utilization of ketones by isolated tissues at various stages of maturation and maternal nutrition during late gestation. | The availability and utilization of B-hydroxybutyrate as an alternate oxidative fuel during fasting hypoglycemia has been examined in the rat conceptus at 18 and 20 days gestation. A 48-hr maternal fast between days 16 and 18 or 18 and 20 resulted in a 50% fall in fetal glucose levels and a marked rise in B-hydroxybuty... | Fetal fuels. I. Utilization of ketones by isolated tissues at various stages of maturation and maternal nutrition during late gestation. The availability and utilization of B-hydroxybutyrate as an alternate oxidative fuel during fasting hypoglycemia has been examined in the rat conceptus at 18 and 20 days gestation. A ... | [
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PMID:16196 | Studies on the toxin of Aspergillus fumigatus. VII. Purification and some properities of hemolytic toxin (asp-hemolysin) from culture filtrates and mycelia. | A hemolytic toxin has been obtained from mycelia and culture filtrates of Aspergillus fumigatus by the procedures that included precipitation with ammonium sulfate, chromatography of DEAE-Sephadex, affinity chromatography on Concanavalin A-Sepharose and gell filtration on Sephadex G-50, G-100 AND G-150. The purified ho... | Studies on the toxin of Aspergillus fumigatus. VII. Purification and some properities of hemolytic toxin (asp-hemolysin) from culture filtrates and mycelia. A hemolytic toxin has been obtained from mycelia and culture filtrates of Aspergillus fumigatus by the procedures that included precipitation with ammonium sulfate... | [
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PMID:16197 | Resistance mechanism of chloramphenicol in Streptococcus haemolyticus, Streptococcus pneumoniae and Streptococcus faecalis. | The chloramphenicol resistance of Streptococcus haemolyticus, Streptococcus pneumoniae and Streptococcus faecalis isolated from clinical materials was proved to be due to an inactivating enzyme produced by these bacteria. The inactivated products of chloramphenicol were identified as 1-acetoxy, 3-acetoxy and 1,3-diacet... | Resistance mechanism of chloramphenicol in Streptococcus haemolyticus, Streptococcus pneumoniae and Streptococcus faecalis. The chloramphenicol resistance of Streptococcus haemolyticus, Streptococcus pneumoniae and Streptococcus faecalis isolated from clinical materials was proved to be due to an inactivating enzyme pr... | [
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PMID:16198 | [Physiologo-biochemical properties of a chemostatic culture of Bacillus megaterium at different pH values]. | Properties of the chemostat culture of Bacillus megaterium were studied during its growth in the state of stress caused by unfavourable acid and alkaline values of pH. The effect of pH is not specific since changes occur in both energy exchange and constructive metabolism. The common action of hydrogen and hydroxyl ion... | [Physiologo-biochemical properties of a chemostatic culture of Bacillus megaterium at different pH values]. Properties of the chemostat culture of Bacillus megaterium were studied during its growth in the state of stress caused by unfavourable acid and alkaline values of pH. The effect of pH is not specific since chang... | [
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PMID:16203 | Cimetidine in the treatment of duodenal ulcer. | In a double-blind trial performed in two centres, 67 outpatients with endoscopically confirmed duodenal (55) or pyloric canal (12) ulcers received cimetidine (34 patients) or placebo (33 patients) for six weeks. At 6 weeks complete healing of ulcers was significantly increased in patients receiving cimetidine (82%) com... | Cimetidine in the treatment of duodenal ulcer. In a double-blind trial performed in two centres, 67 outpatients with endoscopically confirmed duodenal (55) or pyloric canal (12) ulcers received cimetidine (34 patients) or placebo (33 patients) for six weeks. At 6 weeks complete healing of ulcers was significantly incre... | [
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PMID:16199 | [Methanol oxidation by the NAD-specific dehydrogenase of methane-assimilating yeasts]. | The activity of NAD-specific dehydrogenase (NAD-DH) capable of methanol oxidation was found in cell-free extracts of methanol assimilating yeast cultures Pichia pinus and Candida boidinii. The optimum pH of the incubation mixture for the enzyme is 7.8--7.9; the value of Km of the enzyme for methanol is 1.4-10(-4) M in ... | [Methanol oxidation by the NAD-specific dehydrogenase of methane-assimilating yeasts]. The activity of NAD-specific dehydrogenase (NAD-DH) capable of methanol oxidation was found in cell-free extracts of methanol assimilating yeast cultures Pichia pinus and Candida boidinii. The optimum pH of the incubation mixture for... | [
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PMID:16201 | [Properties of the hexulose phosphate synthase of methylotrophic yeasts and bacteria]. | Properties of hexulose phosphate synthase (HPS) were studied in extracts of the methanol assimilating yeast Candida methylica and the bacterium Arthrobacter globiformis B-175 assimilating methylated amines. HPS is an inducible enzyme which is localized in the soluble fraction of the cells. The effect of the pH of the r... | [Properties of the hexulose phosphate synthase of methylotrophic yeasts and bacteria]. Properties of hexulose phosphate synthase (HPS) were studied in extracts of the methanol assimilating yeast Candida methylica and the bacterium Arthrobacter globiformis B-175 assimilating methylated amines. HPS is an inducible enzyme... | [
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PMID:16202 | A study of cancer of the breast with special reference to its causation and prevention. | Breast feeding, lactational histories, parity, age at marriage, and socio-economic status were compared in 24 patients with carcinoma of breast, 24 healthy controls, and 48 patients suffering from other diseases. They were matched for age, social class and work or trade of the husbands. Breast cancer patients married l... | A study of cancer of the breast with special reference to its causation and prevention. Breast feeding, lactational histories, parity, age at marriage, and socio-economic status were compared in 24 patients with carcinoma of breast, 24 healthy controls, and 48 patients suffering from other diseases. They were matched f... | [
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PMID:16209 | [Cogans's syndrome in childhood (author's transl)]. | A case--report is given of a patient with Cogan's syndrome in childhood. This syndrome consists of non-syphilitic interstitial keratitis and vestibuloauditory symptoms. Visual loss is rare but hearing loss is rapidly progressive. A relation to autoimmune diseases especially to panarteriitis nodosa has been suggested by... | [Cogans's syndrome in childhood (author's transl)]. A case--report is given of a patient with Cogan's syndrome in childhood. This syndrome consists of non-syphilitic interstitial keratitis and vestibuloauditory symptoms. Visual loss is rare but hearing loss is rapidly progressive. A relation to autoimmune diseases espe... | [
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PMID:16212 | Enzyme replacement therapy of exocrine pancreatic insufficiency in man. Relations between in vitro enzyme activities and in vivo potency in commercial pancreatic extracts. | I assayed 16 commercially available pancreatic extracts (representing capsules, tablets and enteric-coated tablets) for enzyme activities and the relation between the in vitro activities and in vivo potency evaluated in man. Lipase activity ranged from 10 to 3600 units per unit, with 11 preparations containing less tha... | Enzyme replacement therapy of exocrine pancreatic insufficiency in man. Relations between in vitro enzyme activities and in vivo potency in commercial pancreatic extracts. I assayed 16 commercially available pancreatic extracts (representing capsules, tablets and enteric-coated tablets) for enzyme activities and the re... | [
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PMID:16210 | A possible histochemical mechanism of dihydrofolate reductase reaction. | The authors propose a hypothesis concerning the mechanism of dihydrofolate reductase reaction, suggesting a combined action of transhydrogenases and diaphorase particularly for this enzyme activity, and generally for the reductases. | A possible histochemical mechanism of dihydrofolate reductase reaction. The authors propose a hypothesis concerning the mechanism of dihydrofolate reductase reaction, suggesting a combined action of transhydrogenases and diaphorase particularly for this enzyme activity, and generally for the reductases. | [
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PMID:16213 | Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules. | To assess the fate and efficacy of orally ingested enzymes in pancreatic insufficiency, we administered pancreatin to six patients by two schedules--eight tablets with a standard meal or two tablets hourly--and in six normal controls, quantified duodenal enzyme activity and related inactiviation of ingested enzymes to ... | Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules. To assess the fate and efficacy of orally ingested enzymes in pancreatic insufficiency, we administered pancreatin to six patients by two schedules--eight tablets with a standard meal or two tablets hourly--and in six norma... | [
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PMID:16215 | [Determination of riboflavin in foods]. | The author examined the conditions under which the lumiflavin method may be used for the determination of riboflavin. Neither the presence of various cations and anions, nor the presence of cellulose, starch and protein exerted any effect on the oxidation with potassium permanganate. The riboflavin losses increased whe... | [Determination of riboflavin in foods]. The author examined the conditions under which the lumiflavin method may be used for the determination of riboflavin. Neither the presence of various cations and anions, nor the presence of cellulose, starch and protein exerted any effect on the oxidation with potassium permangan... | [
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PMID:16219 | Comparative neutron small-angle scattering study of small spherical RNA viruses. | Small-angle neutron scattering from solutions of small RNA viruses has been used to study protein-nucleic acid organisation. In the five viruses investigated the RNA is confined to a sphere of about 100 A radius, with a central hole (with one possible exception). The interpenetration of RNA and protein varies with viru... | Comparative neutron small-angle scattering study of small spherical RNA viruses. Small-angle neutron scattering from solutions of small RNA viruses has been used to study protein-nucleic acid organisation. In the five viruses investigated the RNA is confined to a sphere of about 100 A radius, with a central hole (with ... | [
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PMID:16224 | Effects of neuroleptics on release of 3H-dopamine from slices of rat corpus striatum. | The characteristics of 3H-DA release from striatal slices by electrical stimulation were analyzed and the effects of a number of neuroleptics thereon were examined under different experimental conditions. The butyrophenones, haloperidol and spiroperidol, already at low concentrations (0.1 - 1 micronM) increased basal t... | Effects of neuroleptics on release of 3H-dopamine from slices of rat corpus striatum. The characteristics of 3H-DA release from striatal slices by electrical stimulation were analyzed and the effects of a number of neuroleptics thereon were examined under different experimental conditions. The butyrophenones, haloperid... | [
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PMID:16229 | [Quantitative relationship between neurons of a different mediator nature in the motor nuclei of the cat spinal cord cervical thickening]. | A histochemical analysis of the neuronal composition of the motor nuclei was performed on the cat cervical spinal cord. Motoneurons were distinguished by the location of AChE in the perinuclear space, on the membranes of the granular reticulum, on the axolemma, neurofilaments and neurotubuli, in the synaptosomes and th... | [Quantitative relationship between neurons of a different mediator nature in the motor nuclei of the cat spinal cord cervical thickening]. A histochemical analysis of the neuronal composition of the motor nuclei was performed on the cat cervical spinal cord. Motoneurons were distinguished by the location of AChE in the... | [
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PMID:16232 | Salivary levels of anticonvulsants: a practical approach to drug monitoring. | Phenobarbital, phenytoin, carbamazepine, primidone, and ethosuximide were measured in saliva and plasma obtained simultaneoulsy from 115 patients. A method to correct for the effect of salivary pH on phenobarbital concentration of saliva was developed. Salivary concentrations of these drugs were found to be equivalent ... | Salivary levels of anticonvulsants: a practical approach to drug monitoring. Phenobarbital, phenytoin, carbamazepine, primidone, and ethosuximide were measured in saliva and plasma obtained simultaneoulsy from 115 patients. A method to correct for the effect of salivary pH on phenobarbital concentration of saliva was d... | [
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PMID:16235 | [Guide to the automated calculation of acid-base equilibrium]. | The sequence of calculations that can be entered in the memory of a desk computer for the automatic calculation of acid base balance parameters using data obtained with Astrup's tonometric method is described. A statistical comparison is also made between manually obtained results and those obtained with computer assis... | [Guide to the automated calculation of acid-base equilibrium]. The sequence of calculations that can be entered in the memory of a desk computer for the automatic calculation of acid base balance parameters using data obtained with Astrup's tonometric method is described. A statistical comparison is also made between m... | [
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PMID:16240 | Cataract and gamma-glutamyl cycle in myotonic dystrophy. | Gamma-Glutamyl transpeptidase (gamma-GT) may be responsible for the rapid catabolism and low levels of lenticular glutathione often associated with cataract formation. Elevated levels of serum gamma-GT in patients with myotonic dystrophy suggest that since the defect could be present in all tissues it might be responsi... | Cataract and gamma-glutamyl cycle in myotonic dystrophy. Gamma-Glutamyl transpeptidase (gamma-GT) may be responsible for the rapid catabolism and low levels of lenticular glutathione often associated with cataract formation. Elevated levels of serum gamma-GT in patients with myotonic dystrophy suggest that since the de... | [
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PMID:16242 | Are infantile periarteritis nodosa with coronary artery involvement and fatal mucocutaneous lymph node syndrome the same? Comparison of 20 patients from North America with patients from Hawaii and Japan. | We reviewed available clinical and pathologic autopsy material from 20 patients with infantile periarteritis nodosa with coronary artery involvement (IPN) from the continental United States, two Hawaiian patients with fatal mucocutaneous lymph node syndrome (MCLS; Kawasaki disease), and three patients with classical pe... | Are infantile periarteritis nodosa with coronary artery involvement and fatal mucocutaneous lymph node syndrome the same? Comparison of 20 patients from North America with patients from Hawaii and Japan. We reviewed available clinical and pathologic autopsy material from 20 patients with infantile periarteritis nodosa ... | [
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PMID:16244 | [Variation of plasma amino acids in severe hepatitis with encephalopathy 10 cases]. | Plasma levels of different amino acids were observed in 10 patients with severe hepatitis, 9 viral in origin and 1 toxic, over the course of the disease. There would appear to be a close relationship between the onset of encephalopathy and the appearance of a particular pattern in plasma amino acid equilibrium, charact... | [Variation of plasma amino acids in severe hepatitis with encephalopathy 10 cases]. Plasma levels of different amino acids were observed in 10 patients with severe hepatitis, 9 viral in origin and 1 toxic, over the course of the disease. There would appear to be a close relationship between the onset of encephalopathy ... | [
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PMID:16252 | Analgesic action of alpha-adrenolytics in albino mice. | The effect of alpha-adrenolytics: phenoxybenzamine, phentolamine, aceperone, dihydroegotamine, and yohimbine, was tested on reactivity to pain, and on the analgesic action of morphine and pethidine in albino mice. The compounds exert an analgesic effect by themselves, and potentiate the analgesic action of threshold do... | Analgesic action of alpha-adrenolytics in albino mice. The effect of alpha-adrenolytics: phenoxybenzamine, phentolamine, aceperone, dihydroegotamine, and yohimbine, was tested on reactivity to pain, and on the analgesic action of morphine and pethidine in albino mice. The compounds exert an analgesic effect by themselv... | [
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PMID:16256 | The different effects of sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin in man. | The influence of oral sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin has been studied in normal volunteers. While sodium bicarbonate appeared to increase indomethacin absorption, aluminium hydroxide markedly reduced both the rate and extent of absorption. The buccal absorption of indometha... | The different effects of sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin in man. The influence of oral sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin has been studied in normal volunteers. While sodium bicarbonate appeared to increase indomethacin absorption, a... | [
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PMID:16253 | Factors which might modify analgesic effect of morphine in differentially housed rats. | The analgesic effect of morphine was studied by tail compression method in grouped and chronically isolated Wistar male rats developing muricide behavior showed increased pain threshold whilst indifferent (non-killer) showed reduced responses to the analgesic action of morphine. "Natural" killer (housed in groups) show... | Factors which might modify analgesic effect of morphine in differentially housed rats. The analgesic effect of morphine was studied by tail compression method in grouped and chronically isolated Wistar male rats developing muricide behavior showed increased pain threshold whilst indifferent (non-killer) showed reduced ... | [
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0.016217... |
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