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PMID:15760 | Comparative anti-hypertensive effectiveness of beta-adrenoreceptor antagonists with different pharmacological properties: dose-response studies during acute and chronic administration. | 1. Immediate and long-term blood pressure-lowering activity of five beta-adrenoreceptor antagonists with different ancillary pharmacological properties were compared in a randomized double-blind placebo controlled factorial trial in twenty-five previously untreated patients with stable uncomplicated essential hypertens... | Comparative anti-hypertensive effectiveness of beta-adrenoreceptor antagonists with different pharmacological properties: dose-response studies during acute and chronic administration. 1. Immediate and long-term blood pressure-lowering activity of five beta-adrenoreceptor antagonists with different ancillary pharmacolo... | [
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PMID:15752 | Clinical pharmacokinetics of sulphasalazine. | Sulphasalazine consists of 5-aminosalicylic acid and sulphapyridine both linked together by an azo bond. Sulphasalazine is clearly useful in long-term management of ulcerative colitis and may be useful in Crohn's disease. The absorption, metabolism and excretion of sulphasalazine is similar in volunteers and patients w... | Clinical pharmacokinetics of sulphasalazine. Sulphasalazine consists of 5-aminosalicylic acid and sulphapyridine both linked together by an azo bond. Sulphasalazine is clearly useful in long-term management of ulcerative colitis and may be useful in Crohn's disease. The absorption, metabolism and excretion of sulphasal... | [
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PMID:15761 | Within-patient comparisons between different anti-hypertensive drugs. | 1. By substituting one anti-hypertensive drug for the other in a panel of hypertensive patients equipotent doses have been determined. 2. Thus 40 mg of propranolol is equivalent to 4-5 mg of pindolol, 98 mg of practolol, 128 mg of alprenolol, 49 mg of metoprolol, 42 mg of tolamolol and 4-4 mg of timolol. 3. Bendorfluaz... | Within-patient comparisons between different anti-hypertensive drugs. 1. By substituting one anti-hypertensive drug for the other in a panel of hypertensive patients equipotent doses have been determined. 2. Thus 40 mg of propranolol is equivalent to 4-5 mg of pindolol, 98 mg of practolol, 128 mg of alprenolol, 49 mg o... | [
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PMID:15762 | Initial treatment of the young hypertensive: thiazide diuretic or beta-adrenoreceptor-blocking agent in a single daily dose? | 1. Nine men aged 20-33 years with essential hypertension measured their own blood pressure at home, lying and standing, three times daily, under conditions of everyday living. The last 14 days' readings (eighty-four observations) from control and treatment periods of at least 4 weeks' duration were used to calculate me... | Initial treatment of the young hypertensive: thiazide diuretic or beta-adrenoreceptor-blocking agent in a single daily dose? 1. Nine men aged 20-33 years with essential hypertension measured their own blood pressure at home, lying and standing, three times daily, under conditions of everyday living. The last 14 days' r... | [
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PMID:15763 | Control of renin secretion in vivo and in vitro in rats: arguments in favour of a precursor form of renin and of a role of a microtubular system. | 1. The morphology of the juxtaglomerular apparatus, plasma renin activity, plasma renin substrate and renal renin have been studied in rats after maximal stimulation by bilateral adrenalectomy and salt depletion, and also after blocking this stimulation by deoxycorticosterone and salt load. 2. After stimulation the jux... | Control of renin secretion in vivo and in vitro in rats: arguments in favour of a precursor form of renin and of a role of a microtubular system. 1. The morphology of the juxtaglomerular apparatus, plasma renin activity, plasma renin substrate and renal renin have been studied in rats after maximal stimulation by bilat... | [
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PMID:15766 | Toxicology of ipecac: a review. | The general effectiveness and safety of Ipecac syrup, per se, has not been questioned, but rather an attempt has been made to consolidate pertinent literature dealing with the toxic manifestations of Ipecac fluid extract. Ipecac contains both emetine and cephaeline and the toxicity of Ipecac fluid extract is consistent... | Toxicology of ipecac: a review. The general effectiveness and safety of Ipecac syrup, per se, has not been questioned, but rather an attempt has been made to consolidate pertinent literature dealing with the toxic manifestations of Ipecac fluid extract. Ipecac contains both emetine and cephaeline and the toxicity of Ip... | [
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PMID:15794 | Insect reactions related to sports. | Only the rare practicing physician does not see at least a few patients during the warm summer months who have come off second best in an encounter with a member of Hymenoptera or one or the other of the various species of the phylum Arthropoda. Next to children and certain occupational groups such as farmers, it is pr... | Insect reactions related to sports. Only the rare practicing physician does not see at least a few patients during the warm summer months who have come off second best in an encounter with a member of Hymenoptera or one or the other of the various species of the phylum Arthropoda. Next to children and certain occupatio... | [
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PMID:15797 | A plea for comprehensive treatment for the hyperkinetic child. | Having a multimodality approach to the hyperkinetic child may make the difference between success or failure in the management of the child. Frequently, one or two modes of intervention alone will not be sufficient. Although several modes of intervention have been described, the helping professional must exercise his o... | A plea for comprehensive treatment for the hyperkinetic child. Having a multimodality approach to the hyperkinetic child may make the difference between success or failure in the management of the child. Frequently, one or two modes of intervention alone will not be sufficient. Although several modes of intervention ha... | [
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PMID:15802 | Metabolism and disposition of trifluoperazine in the rat. II. Kinetics after oral and intravenous administration in acutely and chronically treated animals. | Male rats received 12.3 micronmol of trifluoperazine (CF3-PER) per kg orally or into the tail vein, and the kinetics of the drug and of its metabolites, 7-hydroxytrifluoperazine and desmethyltrifluoperazine, were followed from 0.5 to 8 hr after dosage. Brain, liver, lung, kidney, and plasma were analyzed by a thin-laye... | Metabolism and disposition of trifluoperazine in the rat. II. Kinetics after oral and intravenous administration in acutely and chronically treated animals. Male rats received 12.3 micronmol of trifluoperazine (CF3-PER) per kg orally or into the tail vein, and the kinetics of the drug and of its metabolites, 7-hydroxyt... | [
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PMID:15803 | Plasma levels of real and "apparent" hydralazine in man and rat. | Derivatization of hydralazine in plasma under acidic conditions yields values for the concentrations of "apparent" hydralazine that are dependent on the pH in the derivatization step. The results have been explained by postulating the existence of acid-hydrolyzable conjugates of unknown structure. These metabolites app... | Plasma levels of real and "apparent" hydralazine in man and rat. Derivatization of hydralazine in plasma under acidic conditions yields values for the concentrations of "apparent" hydralazine that are dependent on the pH in the derivatization step. The results have been explained by postulating the existence of acid-hy... | [
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PMID:15804 | Comparative metabolism of fenclorac in rat, dog, monkey, and man. | Fenclorac (alpha,m-dichloro-p-cyclohexylphenylacetic acid, diethylammonium salt), a new nonsteroidal anti-inflammatory agent, was rapidly and quantitatively absorbed from the gastrointestinal tract of rat, dog, monkey, and man following oral administration of a solution of 14C-labeled compound. Radiochromatography and ... | Comparative metabolism of fenclorac in rat, dog, monkey, and man. Fenclorac (alpha,m-dichloro-p-cyclohexylphenylacetic acid, diethylammonium salt), a new nonsteroidal anti-inflammatory agent, was rapidly and quantitatively absorbed from the gastrointestinal tract of rat, dog, monkey, and man following oral administrati... | [
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PMID:15805 | Urinary metabolites of amitriptyline in the dog. | Dogs excreted approximately 45% of an oral dose of 14C-amitriptyline (30 mg/kg) in the urine in 24 hr. Two new urinary metabolites of the drug were identified as dihydrodiol derivatives of amitriptyline and nortriptyline, respectively. The major metabolite in dog urine was 10-hydroxyamitriptyline, excreted mainly in co... | Urinary metabolites of amitriptyline in the dog. Dogs excreted approximately 45% of an oral dose of 14C-amitriptyline (30 mg/kg) in the urine in 24 hr. Two new urinary metabolites of the drug were identified as dihydrodiol derivatives of amitriptyline and nortriptyline, respectively. The major metabolite in dog urine w... | [
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PMID:15806 | Identification of 3-O-methyl-alpha-methyldopamine as a urinary metabolite of 3,4-methylenedioxyamphetamine in dog and monkey. | 3-O-Methyl-alpha-methyldopamine has been separated by gas-liquid chromatography (GC) as a metabolite of MDA in the urine of dog and monkey. The metabolite was identified as its mono- and di-trifluoroacetyl derivatives by comparison of their GC and GC-mass spectral properties with those of synthetic compounds. The amoun... | Identification of 3-O-methyl-alpha-methyldopamine as a urinary metabolite of 3,4-methylenedioxyamphetamine in dog and monkey. 3-O-Methyl-alpha-methyldopamine has been separated by gas-liquid chromatography (GC) as a metabolite of MDA in the urine of dog and monkey. The metabolite was identified as its mono- and di-trif... | [
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PMID:15807 | Metabolism of pyrazole. Structure elucidation of urinary metabolites. | Pyrazole has been widely used as an inhibitor of alcohol dehydrogenase both in vivo and in vitro. Very little attention has been paid to the metabolism of this agent and possible biological activity of any metabolites. Several isotopic variants of pyrazole, both stable and radioactive, were used in a study of its metab... | Metabolism of pyrazole. Structure elucidation of urinary metabolites. Pyrazole has been widely used as an inhibitor of alcohol dehydrogenase both in vivo and in vitro. Very little attention has been paid to the metabolism of this agent and possible biological activity of any metabolites. Several isotopic variants of py... | [
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PMID:15809 | Enhanced naloxone distribution to the brain by morphine pretreatment in mice. | An increase in the disposition of naloxone to the mouse brain was observed for animals previously exposed to morphine. Compared to controls, mice receiving morphine sulfate (10 mg/kg, sc) 3 hr prior to naloxone had a 28% increase in naloxone concentration in brain (200 to 260 pmol of naloxone per g of brain) 10 min aft... | Enhanced naloxone distribution to the brain by morphine pretreatment in mice. An increase in the disposition of naloxone to the mouse brain was observed for animals previously exposed to morphine. Compared to controls, mice receiving morphine sulfate (10 mg/kg, sc) 3 hr prior to naloxone had a 28% increase in naloxone ... | [
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PMID:15808 | The metabolism and toxicity of halogenated carbanilides. Biliary metabolites of 3,4,4'-trichlorocarbanilide and 3-trifluoromethyl-4,4'-dichlorocarbanilide in the rat. | In separate experiments, after repeated oral administration of 3,4,4'-trichlorocarbanilide (TCC) and 3-trifluoromethyl-4,4'-dichlorocarbanilide (TFC) to rats, the biliary metabolites of each were isolated and identified. The major TCC biliary metabolite was found to be 2'-hydroxy-TCC. This compound was isolated mainly ... | The metabolism and toxicity of halogenated carbanilides. Biliary metabolites of 3,4,4'-trichlorocarbanilide and 3-trifluoromethyl-4,4'-dichlorocarbanilide in the rat. In separate experiments, after repeated oral administration of 3,4,4'-trichlorocarbanilide (TCC) and 3-trifluoromethyl-4,4'-dichlorocarbanilide (TFC) to ... | [
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PMID:15812 | O-Demethylation of p-nitroanisole by Escherichia coli. Stimulation by phenobarbital. | Intact cells of the bacterium Escherichia coli ATCC 11229, can convert p-nitroanisole into p-nitrophenol. The presence of phenobarbital in the culture medium during growth of the cells results in an inhibition of bacterial cell mass and an increased ability of the bacterial cell to carry out the O-demethylation reactio... | O-Demethylation of p-nitroanisole by Escherichia coli. Stimulation by phenobarbital. Intact cells of the bacterium Escherichia coli ATCC 11229, can convert p-nitroanisole into p-nitrophenol. The presence of phenobarbital in the culture medium during growth of the cells results in an inhibition of bacterial cell mass an... | [
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PMID:15810 | Lung pH and pulmonary absorption of nonvolatile drugs in the rat. | The effect of pH on pulmonary absorption of nonvolatile drugs was investigated in the rat. Krebs-Ringer phosphate solutions (pH 6.2 and 7.4), Krebs-Ringer pyrophosphate solution (pH 8.4), or an unbuffered salt solution containing a drug were administered through tight-fitting tracheal cannulas to anesthetized animals. ... | Lung pH and pulmonary absorption of nonvolatile drugs in the rat. The effect of pH on pulmonary absorption of nonvolatile drugs was investigated in the rat. Krebs-Ringer phosphate solutions (pH 6.2 and 7.4), Krebs-Ringer pyrophosphate solution (pH 8.4), or an unbuffered salt solution containing a drug were administered... | [
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PMID:15813 | Comparison of the metabolism of parathion by a rat liver reconstituted mixed-function oxidase enzyme system and by a system containing cumene hydroperoxide and purified rat liver cytochrome P-450. | The metabolism of parathion by a reconstituted mixed-function oxidase enzyme system (rat liver cytochrome P-450, NADPH-cytochrome c reductase, dilauroyl phosphatidylcholine, deoxycholate, and NADPH) or a cumene hydroperoxide system (cytochrome P-450, dilauroyl phosphatidylcholine, and cumene hydroperoxide) have been co... | Comparison of the metabolism of parathion by a rat liver reconstituted mixed-function oxidase enzyme system and by a system containing cumene hydroperoxide and purified rat liver cytochrome P-450. The metabolism of parathion by a reconstituted mixed-function oxidase enzyme system (rat liver cytochrome P-450, NADPH-cyto... | [
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PMID:15814 | Metabolism of haloforms to carbon monoxide. I. In vitro studies. | Trihalomethanes (haloforms) were metabolized to carbon monoxide by a rat liver microsomal fraction requiring both NADPH and molecular oxygen for maximal activity. GSH alone did not serve as a cofactor; however, GSH in the presence of NADPH and oxygen produced an 8-fold increase in the metabolism of bromoform to CO. Sim... | Metabolism of haloforms to carbon monoxide. I. In vitro studies. Trihalomethanes (haloforms) were metabolized to carbon monoxide by a rat liver microsomal fraction requiring both NADPH and molecular oxygen for maximal activity. GSH alone did not serve as a cofactor; however, GSH in the presence of NADPH and oxygen prod... | [
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PMID:15818 | Neuropsychological deficit in polydrug users. A preliminary report of the findings of the collaborative neuropsychological study of polydrug users. | The Collaborative Neuropsychological Study of Polydrug Users performed extensive neuropsychological assessments on 15 polydrug users 3 weeks after their enrollment in each of eight polydrug demonstration programs. Fifty-six (37%) of these subjects exhibited neuropsychological deficit. This deficit was partially related... | Neuropsychological deficit in polydrug users. A preliminary report of the findings of the collaborative neuropsychological study of polydrug users. The Collaborative Neuropsychological Study of Polydrug Users performed extensive neuropsychological assessments on 15 polydrug users 3 weeks after their enrollment in each ... | [
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PMID:15811 | Disposition of carbamazepine and its 10,11-epoxide metabolite in the isolated perfused rat liver. | The disposition of carbamazepine and its metabolite, the 10,11-epoxide, was investigated in isolated perfused livers from control and phenobarbital-pretreated rats. The mean hepatic clearance of carbamazepine was 0.28 ml per min per g of liver corresponding to a mean extraction ratio of 0.16 and a mean intrinsic cleara... | Disposition of carbamazepine and its 10,11-epoxide metabolite in the isolated perfused rat liver. The disposition of carbamazepine and its metabolite, the 10,11-epoxide, was investigated in isolated perfused livers from control and phenobarbital-pretreated rats. The mean hepatic clearance of carbamazepine was 0.28 ml p... | [
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PMID:15816 | Induction of hepatic aryl hydrocarbon hydroxylase and epoxide hydrase in Wistar rats pretreated with oral methadone hydrochloride. | Methadone-HCl added to the drinking water of adult female Wistar rats for 4 weeks produced an increase in the aryl hydrocarbon hydroxylase activity of the hepatic microsomal fraction to 222% of control levels. No change was seen in epoxide hydrase activity. In contrast, when male rats were treated similarly, there was ... | Induction of hepatic aryl hydrocarbon hydroxylase and epoxide hydrase in Wistar rats pretreated with oral methadone hydrochloride. Methadone-HCl added to the drinking water of adult female Wistar rats for 4 weeks produced an increase in the aryl hydrocarbon hydroxylase activity of the hepatic microsomal fraction to 222... | [
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PMID:15817 | Metabolism and disposition of trifluoperazine in the rat. I. A thin-layer chromatographic method for the measurement of trifluoperazine and its metabolites in rat tissues. | A method has been developed for quantitative measurement of trifluoperazine and its metabolites, 7-hydroxytrifluoperazine and desmethyltrifluoperazine, in rat organs. Trifluoperazine sulfoxide could also be assayed, but it proved to represent a very minor part only of total biotransformation products in tissues. Alkali... | Metabolism and disposition of trifluoperazine in the rat. I. A thin-layer chromatographic method for the measurement of trifluoperazine and its metabolites in rat tissues. A method has been developed for quantitative measurement of trifluoperazine and its metabolites, 7-hydroxytrifluoperazine and desmethyltrifluoperazi... | [
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PMID:15815 | Probenecid metabolism in vitro with rat, mouse, and human liver preparations. Studies of factors affecting the site of oxidation. | The metabolism of probenecid in vitro was investigated with rat, mouse, and human liver preparations. As in previous in vivo studies, metabolism in vitro was found to be limited to the side chain. This metabolism involved mono-N-depropylation and hydroxylation in the 2- and 3-positions (3-hydroxy probenecid was in part... | Probenecid metabolism in vitro with rat, mouse, and human liver preparations. Studies of factors affecting the site of oxidation. The metabolism of probenecid in vitro was investigated with rat, mouse, and human liver preparations. As in previous in vivo studies, metabolism in vitro was found to be limited to the side ... | [
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PMID:15821 | Inhibitory effect of immobilization stress on depression of liver tyrosine aminotransferase and tryptophan pyrrolase by glucose feeding in rats. | In alloxan diabetic rats a stimulatory effect of stress on the activity of liver phosphoenolpyruvate carboxykinase seems to be very likely. In intact animals the inhibitory effect of glucose feeding (15% glucose instead of laboratory diet and water) on the activity of liver tyrosine aminotransferase (TAT) and tryptopha... | Inhibitory effect of immobilization stress on depression of liver tyrosine aminotransferase and tryptophan pyrrolase by glucose feeding in rats. In alloxan diabetic rats a stimulatory effect of stress on the activity of liver phosphoenolpyruvate carboxykinase seems to be very likely. In intact animals the inhibitory ef... | [
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PMID:15822 | Purification of bovine thyroid peroxidase. | Trypsin-solubilized peroxidase activity from beef subcellular particles was resolved by DEAE-cellulose chromatography into 5 fractions, which contained enzymatically active components that ranged in molecular size from 73,000 to 340,000 daltons. The most active fraction (mol wt, 92,000 by gel filtration) was further pu... | Purification of bovine thyroid peroxidase. Trypsin-solubilized peroxidase activity from beef subcellular particles was resolved by DEAE-cellulose chromatography into 5 fractions, which contained enzymatically active components that ranged in molecular size from 73,000 to 340,000 daltons. The most active fraction (mol w... | [
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PMID:15823 | Beta-adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated bovine parathyroid cells. | The effects of beta-adrenergic agonists and antagonists on cyclic AMP (cAMP) accumulation and parathyroid hormone (PTH) release from isolated bovine parathyroid cells have been determined. Beta-adrenergic agonists markedly stimulate cAMP production and PTH release with an order of potency (-) isoproterenol greater than... | Beta-adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated bovine parathyroid cells. The effects of beta-adrenergic agonists and antagonists on cyclic AMP (cAMP) accumulation and parathyroid hormone (PTH) release from isolated bovine parathyroid cells have been determined. Beta-adre... | [
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PMID:15824 | Direct identification of beta-adrenergic receptors on isolated bovine parathyroid cells. | The radioiodinated beta-blocker iodohydroxybenzylpindolol ([125I]HYP) has been used to identify directly and characterize beta-adrenergic receptors in isolated bovine parathyroid cells. [125I]HYP was bound rapidly and reversibly to isolated bovine parathyroid cell membranes. Scatchard analysis revealed a single class o... | Direct identification of beta-adrenergic receptors on isolated bovine parathyroid cells. The radioiodinated beta-blocker iodohydroxybenzylpindolol ([125I]HYP) has been used to identify directly and characterize beta-adrenergic receptors in isolated bovine parathyroid cells. [125I]HYP was bound rapidly and reversibly to... | [
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PMID:15825 | [Testosterone reserve capacity in prepubertal and juvenile testes after sugery for undescended testis]. | Tests testosterone reserve capacity of 6--15 year-old boys was estimated after operative correction of testicular maldescensus by a maximal stimulation test. Subnormal plasma testosterone levels were found in only 2 out of 14 patients with bilateral and 4 with unilateral orchidopexy. Prepubertal boys with unilateral an... | [Testosterone reserve capacity in prepubertal and juvenile testes after sugery for undescended testis]. Tests testosterone reserve capacity of 6--15 year-old boys was estimated after operative correction of testicular maldescensus by a maximal stimulation test. Subnormal plasma testosterone levels were found in only 2 ... | [
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PMID:15826 | Estimation of pregnenolone synthesis in rat adrenal homogenates: some cofactor requirements: effects of stress, hypophysectomy, cortisone and ACTH. | Pregnenolone synthesis was estimated in whole adrenal homogenates incubated in the presence of cyanoketone (2alpha-cyano-4,4,17alpha-trimethyl-androst-5-en-17beta-ol-3-one). The yield of pregnenolone depended on the type of incubation medium employed. Both Ca++ and bovine serum albumin (BSA) markedly stimulated the rat... | Estimation of pregnenolone synthesis in rat adrenal homogenates: some cofactor requirements: effects of stress, hypophysectomy, cortisone and ACTH. Pregnenolone synthesis was estimated in whole adrenal homogenates incubated in the presence of cyanoketone (2alpha-cyano-4,4,17alpha-trimethyl-androst-5-en-17beta-ol-3-one)... | [
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PMID:15827 | The effect of repeated immobilization on the level of plasma corticosterone and on the activity of several liver enzymes in rats. | The effect of repeated stress on the level of plasma corticosterone and on the activity of several target enzymes for this hormone in the liver was studied. In adult male rats immobilized for 2.5 hrs daily, on day 7 the response of both plasma corticosterone and hepatic tyrosine aminotransferase is modified: After sim... | The effect of repeated immobilization on the level of plasma corticosterone and on the activity of several liver enzymes in rats. The effect of repeated stress on the level of plasma corticosterone and on the activity of several target enzymes for this hormone in the liver was studied. In adult male rats immobilized f... | [
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PMID:15828 | Tyramine oxidase activity in needle biopsy of normal livers and diseased livers. | Tyramine oxidase and UDP-glucuronyl transferase activities were determined in 52 diseased livers obtained by needle biopsy. 14 liver specimens were also subjected to acetyl CoA carboxylase determination. Tyramine oxidase level was elevated in livers with nonalcoholic fatty change or toxic hepatitis, and reduced in live... | Tyramine oxidase activity in needle biopsy of normal livers and diseased livers. Tyramine oxidase and UDP-glucuronyl transferase activities were determined in 52 diseased livers obtained by needle biopsy. 14 liver specimens were also subjected to acetyl CoA carboxylase determination. Tyramine oxidase level was elevated... | [
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PMID:15829 | Interactions of divalent cations and nucleotides with solubilized cardiac guanylate cyclase. | Some properties of guanylate cyclase, which was solubilized from the rabbit heart washed particles by the treatment with Triton X-100, were investigated. The solubilized enzyme activity was stimulated by Mg2+ in the presence of low (subsaturating) Mn2+ (GTP is greater than Mn2+); under these conditions, Ga2+ was inhibi... | Interactions of divalent cations and nucleotides with solubilized cardiac guanylate cyclase. Some properties of guanylate cyclase, which was solubilized from the rabbit heart washed particles by the treatment with Triton X-100, were investigated. The solubilized enzyme activity was stimulated by Mg2+ in the presence of... | [
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PMID:15830 | Hepatic alkaline phosphatase isoenzymes: isolation, characterization and differential alteration. | Although it is generally believed that hepatic alkaline phosphatase is localized to liver plasma membranes, 63% is present in the cytosol fraction after ultracentrifugation of rat liver homogenates. Divalent cation requirements, heat inactivation, pH optima, Km and chemical inhibition characteristics of partially purif... | Hepatic alkaline phosphatase isoenzymes: isolation, characterization and differential alteration. Although it is generally believed that hepatic alkaline phosphatase is localized to liver plasma membranes, 63% is present in the cytosol fraction after ultracentrifugation of rat liver homogenates. Divalent cation require... | [
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PMID:15831 | The interaction of phospholipid membranes and detergents with glutamate dehydrogenase. | 1. The interaction of beef liver glutamate dehydrogenase with cardiolipin from both beef liver mitochondria and beef heart mitochondria, with phosphatidylcholine from both beef liver mitochondria and egg-yolk, and with beef brain phosphatidylserine was investigated by steady-state kinetic methods. 2. the phosphatidylch... | The interaction of phospholipid membranes and detergents with glutamate dehydrogenase. 1. The interaction of beef liver glutamate dehydrogenase with cardiolipin from both beef liver mitochondria and beef heart mitochondria, with phosphatidylcholine from both beef liver mitochondria and egg-yolk, and with beef brain pho... | [
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PMID:15832 | The interaction of phospholipid membranes and detergents with glutamate dehydrogenase. | 1. Both the anionic detergent sodium dodecylsulphate and the cationic detergent cetyltrimethylammonium bromide quenched the protein fluorescence of glutamate dehydrogenase. The anionic compound was more effective and brought about 50% quenching at a detergent concentration of 0.4 mM. The zwitterionic amphiphile, lysole... | The interaction of phospholipid membranes and detergents with glutamate dehydrogenase. 1. Both the anionic detergent sodium dodecylsulphate and the cationic detergent cetyltrimethylammonium bromide quenched the protein fluorescence of glutamate dehydrogenase. The anionic compound was more effective and brought about 50... | [
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PMID:15833 | Purification and properties of pyrazon dioxygenase from pyrazon-degrading bacteria. | Chromatography on DEAE-cellulose and gel filtration on Sephadex revealed that pyrazon dioxygenase from pyrazon-degrading bacteria consists of three different enzyme components. No component alone oxidizes the phenyl moiety of pyrazon, only when the three components are combined can oxidation be detected. Following elec... | Purification and properties of pyrazon dioxygenase from pyrazon-degrading bacteria. Chromatography on DEAE-cellulose and gel filtration on Sephadex revealed that pyrazon dioxygenase from pyrazon-degrading bacteria consists of three different enzyme components. No component alone oxidizes the phenyl moiety of pyrazon, o... | [
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PMID:15834 | Antibodies and autoantibodies of glycogen phosphorylase b: inactivation of pig and rabbit enzymes. | Pig skeletal muscle glycogen phosphorylase b was purified using ammonium sulfate fractionation, DEAE-Sephadex A-50 and Sephadex G-200 column chromatography. The purified enzyme was used to immunize rabbits in the presence or in the absence of complete Freund adjuvant. Antibodies against pig phosphorylase in pure form w... | Antibodies and autoantibodies of glycogen phosphorylase b: inactivation of pig and rabbit enzymes. Pig skeletal muscle glycogen phosphorylase b was purified using ammonium sulfate fractionation, DEAE-Sephadex A-50 and Sephadex G-200 column chromatography. The purified enzyme was used to immunize rabbits in the presence... | [
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PMID:15835 | Cathepsin L. A new proteinase from rat-liver lysosomes. | 1. Cathepsin L was purified from rat liver lysosomes by cell fractionation, osmotic disruption of the lysosomes in the lysosomal mitochondrial pellet, gel filtration of the lysosomal extract and chromatography on CM-Sephadex. 2. Cathepsin L is a thiol proteinase and exists in several multiple forms visible on the disc ... | Cathepsin L. A new proteinase from rat-liver lysosomes. 1. Cathepsin L was purified from rat liver lysosomes by cell fractionation, osmotic disruption of the lysosomes in the lysosomal mitochondrial pellet, gel filtration of the lysosomal extract and chromatography on CM-Sephadex. 2. Cathepsin L is a thiol proteinase a... | [
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PMID:15836 | Anabolic ornithine carbamolytransferase of Pseudomonas. The bases of its functional specialization. | The anabolic ornithine carbamoyltransferase of Pseudomonas appears to be extremely specialized. Unlike the other carbamoyltransferases studied, this enzyme catalyzes the phosphorolytic cleavage of citrulline with a very poor efficiency. The main goal of this paper is to understand what, in the catalytic process, causes... | Anabolic ornithine carbamolytransferase of Pseudomonas. The bases of its functional specialization. The anabolic ornithine carbamoyltransferase of Pseudomonas appears to be extremely specialized. Unlike the other carbamoyltransferases studied, this enzyme catalyzes the phosphorolytic cleavage of citrulline with a very ... | [
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PMID:15837 | The kinetics of reoxidation of reduced benzylamine oxidase. | 1. The mechanism of reoxidation of reduced benzylamine oxidase has been investigated at different pH between 6 and 10 by steady-state and transient-state kinetic methods. 2. The reoxidation process involves minimally a second-order interaction between reduced enzyme and oxygen leading to the formation of a spectrally m... | The kinetics of reoxidation of reduced benzylamine oxidase. 1. The mechanism of reoxidation of reduced benzylamine oxidase has been investigated at different pH between 6 and 10 by steady-state and transient-state kinetic methods. 2. The reoxidation process involves minimally a second-order interaction between reduced ... | [
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PMID:15838 | Studies of glutamate dehydrogenase. Methionine-169: the preferentially carboxymethylated residue. | In phosphate buffer at pH 7.0, 5,5'-dithio-bis(2-nitrobenzoic acid), N-ethylmaleimide or iodoacetamide do not alter the activity of beef liver glutamate dehydrogenase. Iodoacetate, however, inactivities the enzyme irreversibility by alkylation. Combined addition of the coenzyme NADH and the substrate 2-oxoglutarate or ... | Studies of glutamate dehydrogenase. Methionine-169: the preferentially carboxymethylated residue. In phosphate buffer at pH 7.0, 5,5'-dithio-bis(2-nitrobenzoic acid), N-ethylmaleimide or iodoacetamide do not alter the activity of beef liver glutamate dehydrogenase. Iodoacetate, however, inactivities the enzyme irrevers... | [
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PMID:15839 | Structural studies on periodate-oxidized chicken ovomucoid. Spectral behaviour of the tyrosine residues. | About 50% of the carbohydrate moiety of ovomucoid was destroyed by periodate oxidation. The oxidation was carried out for 6 h or 24 h. The data obtained showed that in the carbohydrate chain 2-5 glucosamines and 1-2 neutral sugar residues were decomposed with the consumption of 16 mol and 29 mol of periodate respective... | Structural studies on periodate-oxidized chicken ovomucoid. Spectral behaviour of the tyrosine residues. About 50% of the carbohydrate moiety of ovomucoid was destroyed by periodate oxidation. The oxidation was carried out for 6 h or 24 h. The data obtained showed that in the carbohydrate chain 2-5 glucosamines and 1-2... | [
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PMID:15840 | The purification and properties of NADP-dependent isocitrate dehydrogenase from ox-heart mitochondria. | The purification of NADP-linked isocitrate dehydrogenase from ox heart mitochondria is described. The molecular weight from gel filtration, sedimentation equilibrium and gel electrophoresis is 90000+/-4000, and there are two subunits in the molecule each of which binds NADPH with enhancement of the coenzyme fluorescenc... | The purification and properties of NADP-dependent isocitrate dehydrogenase from ox-heart mitochondria. The purification of NADP-linked isocitrate dehydrogenase from ox heart mitochondria is described. The molecular weight from gel filtration, sedimentation equilibrium and gel electrophoresis is 90000+/-4000, and there ... | [
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PMID:15841 | Glycosaminoglycans and glycoproteins in metachromatic leucodystrophy. | A study is reported of the brain glycoproteins and the glycosaminoglycans in a case of infantile metachromatic leucodystrophy, associated with a ponto-cerebellar systemic atrophy, verified by autopsy. The glycosaminoglycan concentrations in the grey matter were within the normal range, while in the white matter they we... | Glycosaminoglycans and glycoproteins in metachromatic leucodystrophy. A study is reported of the brain glycoproteins and the glycosaminoglycans in a case of infantile metachromatic leucodystrophy, associated with a ponto-cerebellar systemic atrophy, verified by autopsy. The glycosaminoglycan concentrations in the grey ... | [
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PMID:15842 | Prolongation of rat renal allograft survival by cyclophosphamide and intravenous donor-specific antigens. | Specific immunological hyporeactivity to Ag-B incompatible rat renal allografts was achieved after pretreatment of the recipients with donor strain platelets or spleen cells and cyclophosphamide (CY). The longest survival times were observed in animals pretreated with a single 75 mg/kg dose of CY together with 2 X 10(1... | Prolongation of rat renal allograft survival by cyclophosphamide and intravenous donor-specific antigens. Specific immunological hyporeactivity to Ag-B incompatible rat renal allografts was achieved after pretreatment of the recipients with donor strain platelets or spleen cells and cyclophosphamide (CY). The longest s... | [
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PMID:15843 | Stress and cardiovascular disease. | Currently the role of stress as a potential factor in cardiovascular disease is receiving considerable attention. Accordingly, it is important to know how it is defined and identified, how it affects the cardiovascular system and how it can be managed with the knowledge presently available. An overview of the present b... | Stress and cardiovascular disease. Currently the role of stress as a potential factor in cardiovascular disease is receiving considerable attention. Accordingly, it is important to know how it is defined and identified, how it affects the cardiovascular system and how it can be managed with the knowledge presently avai... | [
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PMID:15844 | Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake. | Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 weeks. The ethanol was divided into five daily doses and taken so that blood ethanol levels never exceeded 0.04% (w/v). During the latter part of the ethanol intake period, there was a significant, transient increase of plasma triglyceride (TG) con... | Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake. Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 weeks. The ethanol was divided into five daily doses and taken so that blood ethanol levels never exceeded 0.04% (w/v). During the latter part of the ethanol int... | [
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PMID:15845 | Plasma concentrations, bioavailability and dissolution of chlorpropamide. | The bioavailability of chlorpropamide from two new formulations (Melitase tablets) has been compared to that from a reference formulation which is currently in clinical use as a hypoglycaemic agent. In both rate and extent of bioavailability, all three formulations may be considered equivalent, providing allowances are... | Plasma concentrations, bioavailability and dissolution of chlorpropamide. The bioavailability of chlorpropamide from two new formulations (Melitase tablets) has been compared to that from a reference formulation which is currently in clinical use as a hypoglycaemic agent. In both rate and extent of bioavailability, all... | [
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PMID:15846 | Tachyphylaxis to beta-adrenoceptor agonists in guinea pig airway smooth muscle in vivo and in vitro. | Beta-Adrenoceptor tachyphylaxis was induced by incubating spirally cut guinea pig tracheas with isoproterenol (2.4 x 10(-7) M) for 20 min. This incubation reduced the relaxant effects of catecholamines but not of dibutyryl cyclic AMP, theophylline or sodium nitrite. Tracheas incubated with norepinephrine, phosphodieste... | Tachyphylaxis to beta-adrenoceptor agonists in guinea pig airway smooth muscle in vivo and in vitro. Beta-Adrenoceptor tachyphylaxis was induced by incubating spirally cut guinea pig tracheas with isoproterenol (2.4 x 10(-7) M) for 20 min. This incubation reduced the relaxant effects of catecholamines but not of dibuty... | [
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PMID:15847 | Effect of neurohumoral modulators on the morphine-induced hyperthermia in non-tolerant rats. | Wistar rats from one supplier have been shown to exhibit the atypical body temperature responses to morphine. In contrast to commonly used rats, in which morphine induced dose-dependent changes in body temperature, the initial administration of morphine (5, 10, 20, and 40 mg/kg, s.c.) to rats of this particular strain ... | Effect of neurohumoral modulators on the morphine-induced hyperthermia in non-tolerant rats. Wistar rats from one supplier have been shown to exhibit the atypical body temperature responses to morphine. In contrast to commonly used rats, in which morphine induced dose-dependent changes in body temperature, the initial ... | [
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PMID:15848 | Induction of tolerance and withdrawal in rats receiving morphine in the spinal subarachnoid space. | Rats implanted with chronic catheters in the spinal subarachnoid space were given twice daily injections for 7 days of morphine sulfate, either intrathecally into the lumbar subarachnoid space (15 or 50 microng) or i.p. (20 mg/kg). The development of tolerance, as manifested in a reduction of the analgetic efficacy of ... | Induction of tolerance and withdrawal in rats receiving morphine in the spinal subarachnoid space. Rats implanted with chronic catheters in the spinal subarachnoid space were given twice daily injections for 7 days of morphine sulfate, either intrathecally into the lumbar subarachnoid space (15 or 50 microng) or i.p. (... | [
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PMID:15852 | Long-loop reflexes in the tranquilized monkey. | EMG responses to sudden displacement of the forelimb were studied in Cebus monkeys tranquilized with Atravet, a phenothiazine tranquilizer. The monkey's forearm was strapped firmly to a manipulandum handle. A torque motor attached at the pivot point of the handle, under servo control, provided reproducible limb displac... | Long-loop reflexes in the tranquilized monkey. EMG responses to sudden displacement of the forelimb were studied in Cebus monkeys tranquilized with Atravet, a phenothiazine tranquilizer. The monkey's forearm was strapped firmly to a manipulandum handle. A torque motor attached at the pivot point of the handle, under se... | [
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PMID:15855 | [Effect of dimedrol, diazoline, diprazin and ethysine on formation of the primary immune response]. | Tests were conducted on mice of the CBA line, immunized through a single intraperitoneal administration of 0.5 ml of a 5% sheep erythrocytes suspension. Antihistaminic agents were introduced by the intraperitoneal route in a dose of 5 mg/kg, first at one time and then repeatedly at various intervals with respect to the... | [Effect of dimedrol, diazoline, diprazin and ethysine on formation of the primary immune response]. Tests were conducted on mice of the CBA line, immunized through a single intraperitoneal administration of 0.5 ml of a 5% sheep erythrocytes suspension. Antihistaminic agents were introduced by the intraperitoneal route ... | [
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PMID:15860 | [Effect of cholinergic substances on brain potentials induced by tooth pulp stimulation]. | Introduction of the M-cholinomimetic -- arecoline into the ventricle of the rabbit's brain decreases and of the M-cholinolytic -- atropine -- increases the amplitude of primary responses in the sensomotor region of the cortex, arising out of stimulating the dental pulp. The N-cholinomimetic -- lobeline potentiates the ... | [Effect of cholinergic substances on brain potentials induced by tooth pulp stimulation]. Introduction of the M-cholinomimetic -- arecoline into the ventricle of the rabbit's brain decreases and of the M-cholinolytic -- atropine -- increases the amplitude of primary responses in the sensomotor region of the cortex, ari... | [
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PMID:15861 | [Phencarol--an antihistaminic preparation from the quinuclidylcarbinol group]. | A high antihistaminic activity of quinuclidyl-3-diphenylcarbinol (phencarol) has been ascertained. In pharmacological experiments phencarol is superior to dimedrol (diphenhydramine), both as concerns its antihistaminic activity and the duration of its action. Unlike dimedrol and diprazine (promethazine) it has no inhib... | [Phencarol--an antihistaminic preparation from the quinuclidylcarbinol group]. A high antihistaminic activity of quinuclidyl-3-diphenylcarbinol (phencarol) has been ascertained. In pharmacological experiments phencarol is superior to dimedrol (diphenhydramine), both as concerns its antihistaminic activity and the durat... | [
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PMID:15862 | [Study of the effect of corticosterone on erythrocyte membranes by the spin label method]. | Influence of corticosterone on the hare's erythrocyte ghosts is studied by the spin-label method. There exists a correlation between the maximal variation region in the rotational diffusion "frequency" of the spin-labels, covalently linked with the membrane protein, and the hormones concentration range within which the... | [Study of the effect of corticosterone on erythrocyte membranes by the spin label method]. Influence of corticosterone on the hare's erythrocyte ghosts is studied by the spin-label method. There exists a correlation between the maximal variation region in the rotational diffusion "frequency" of the spin-labels, covalen... | [
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PMID:15858 | [Effect of narcotics on impulse conduction in the afferent pathways of visceral nerves]. | In tests set up on cats immobilized with pyraxolone and anatruxonium the effect of non-inhalation narcotics on the evoked potentials of the cortex and subcortical structures with visceral and also somatic, acoustic and photo-stimulation was studied. With stimuli of different modality sodium ethaminal was found to inhib... | [Effect of narcotics on impulse conduction in the afferent pathways of visceral nerves]. In tests set up on cats immobilized with pyraxolone and anatruxonium the effect of non-inhalation narcotics on the evoked potentials of the cortex and subcortical structures with visceral and also somatic, acoustic and photo-stimul... | [
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PMID:15859 | [Effect of several psychopharmacologic preparations on adaptation to stressful conditions]. | Experiments staged on rats demonstrated that the formation of pathological states caused by stress and accompained by the development of ulcerative lesion of the gastric mucosa are associated with the degree of the catecholamines level drop in the mesencephalon and hypothalamus. The application of seduxen and also of c... | [Effect of several psychopharmacologic preparations on adaptation to stressful conditions]. Experiments staged on rats demonstrated that the formation of pathological states caused by stress and accompained by the development of ulcerative lesion of the gastric mucosa are associated with the degree of the catecholamine... | [
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PMID:15873 | The photochemical cycle of bacteriorhodopsin. | The reaction cycle of bacteriorhodopsin in the purple membrane isolated from Halobacterium halobium has been studied by optical absorption spectroscopy using low-temperature and flash kinetic techniques. After absorption of light, bacteriohodopsin passes through at least five distinct intermediates. The temperature and... | The photochemical cycle of bacteriorhodopsin. The reaction cycle of bacteriorhodopsin in the purple membrane isolated from Halobacterium halobium has been studied by optical absorption spectroscopy using low-temperature and flash kinetic techniques. After absorption of light, bacteriohodopsin passes through at least fi... | [
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PMID:15874 | Photochemical and chemical studies on the chromophore of bacteriorhodopsin. | The chromophore (purple complex) of bacteriorhodopsin is reduced by sodium borohydride upon illumination to RPhv with a three-peaked absorption band at 360 nm. Treatment of this reduction product with ultraviolet light or acid yields a modified product from which retro-retinyllysine can be obtained by alkaline hydrolys... | Photochemical and chemical studies on the chromophore of bacteriorhodopsin. The chromophore (purple complex) of bacteriorhodopsin is reduced by sodium borohydride upon illumination to RPhv with a three-peaked absorption band at 360 nm. Treatment of this reduction product with ultraviolet light or acid yields a modified... | [
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PMID:15875 | Proton translocation by ATPase and bacteriorhodopsin. | Stable membrane proteins and lipids are convenient to study biomembranes. Two stable proton translocating proteins were purified and reconstituted into vesicles capable of proton translocation. One was a thermostable ATPase (TF0-F1) of thermophilic bacterium PS3 and the other was rhodopsin of Halobacterium halobium. TF... | Proton translocation by ATPase and bacteriorhodopsin. Stable membrane proteins and lipids are convenient to study biomembranes. Two stable proton translocating proteins were purified and reconstituted into vesicles capable of proton translocation. One was a thermostable ATPase (TF0-F1) of thermophilic bacterium PS3 and... | [
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PMID:15877 | Light-dependent cation gradients and electrical potential in Halobacterium halobium cell envelope vesicles. | Vesicles can be prepared from Halobacterium halobium cell envelopes, which contain properly oriented bacteriorhodopsin and which extrude H+ during illumination. The pH difference that is generated across the membranes is accompanied by an electrical potential of 90-100 mV (interior negative) and the movements of other ... | Light-dependent cation gradients and electrical potential in Halobacterium halobium cell envelope vesicles. Vesicles can be prepared from Halobacterium halobium cell envelopes, which contain properly oriented bacteriorhodopsin and which extrude H+ during illumination. The pH difference that is generated across the memb... | [
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PMID:15878 | Light-activated amino acid transport in Halobacterium halobium envelope vesicles. | Vesicles prepared from Halobacterium halobium cell envelopes accumulate amino acids in response to light-induced electrical and chemical gradients. Nineteen of 20 commonly occurring amino acids have been shown to be actively accumulated by these vesicles in response to illumination or in response to an artificially cre... | Light-activated amino acid transport in Halobacterium halobium envelope vesicles. Vesicles prepared from Halobacterium halobium cell envelopes accumulate amino acids in response to light-induced electrical and chemical gradients. Nineteen of 20 commonly occurring amino acids have been shown to be actively accumulated b... | [
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PMID:15879 | Light energy conservation processes in Halobacterium halobium cells. | In Halobacterium halobium, proton pumping driven by light or by respiration generates an electrochemical potential difference across the membrane. Energy storage in this form is only transient. Cellular energy transducers competing with proton leaks stabilize this free energy as high energy phosphate bonds, electrochem... | Light energy conservation processes in Halobacterium halobium cells. In Halobacterium halobium, proton pumping driven by light or by respiration generates an electrochemical potential difference across the membrane. Energy storage in this form is only transient. Cellular energy transducers competing with proton leaks s... | [
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PMID:15884 | Genetic counselling and prenatal diagnosis for chromosome anomalies. Use of study of spontaneous abortions. | Genetic counselling for chromosome abnormalities must take into account the fact that such anomalies may develop as an error in oogenesis or spermatogenesis or may be transmitted from parents. Since many chromosomally abnormal embryos are spontaneously aborted, parents with repeated unfavorable outcomes of pregnancy or... | Genetic counselling and prenatal diagnosis for chromosome anomalies. Use of study of spontaneous abortions. Genetic counselling for chromosome abnormalities must take into account the fact that such anomalies may develop as an error in oogenesis or spermatogenesis or may be transmitted from parents. Since many chromoso... | [
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PMID:15885 | Prenatal diagnosis of chromosome abnormalities. | It is possible to define a group of prospective parents who are at risk of producing offspring with disability due to chromosomal abnormalities. Such individuals should have evaluation of the 15 or 16 week fetus by karyotype of amniotic fluid cells. The techniques and problems of such diagnostic procedures are discusse... | Prenatal diagnosis of chromosome abnormalities. It is possible to define a group of prospective parents who are at risk of producing offspring with disability due to chromosomal abnormalities. Such individuals should have evaluation of the 15 or 16 week fetus by karyotype of amniotic fluid cells. The techniques and pro... | [
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PMID:15886 | Prenatal diagnosis of inborn errors of metabolism. | More than 50 inborn errors of metabolism can be diagnosed in the fetus. This is accomplished by evaluation of constituents of the cell free amniotic fluid or of cultured or uncultured amniotic fluid cells. Only those syndromes with specific abnormal contributions to amniotic fluid can be so diagnosed. Currently diagnos... | Prenatal diagnosis of inborn errors of metabolism. More than 50 inborn errors of metabolism can be diagnosed in the fetus. This is accomplished by evaluation of constituents of the cell free amniotic fluid or of cultured or uncultured amniotic fluid cells. Only those syndromes with specific abnormal contributions to am... | [
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PMID:15887 | Diagnostic radiology of fetal abnormalities. | Fetal abnormalities involving the skeletal system, central nervous system or soft tissue may be diagnosed by radiologic methods, as may fetal death. Occasionally standard X-ray is used, but often invasive techniques are required, and should be limited to those patients with valid indications. X-rays of specific fetal a... | Diagnostic radiology of fetal abnormalities. Fetal abnormalities involving the skeletal system, central nervous system or soft tissue may be diagnosed by radiologic methods, as may fetal death. Occasionally standard X-ray is used, but often invasive techniques are required, and should be limited to those patients with ... | [
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PMID:15888 | New and future techniques in prenatal diagnosis. | Fetal evaluation may be accomplished in the future using techniques experimental at this time. These include direct visualization of the fetus by endoscopy, biopsy of fetal tissues, and indirect techniques accomplished in the laboratory. It is hoped that in the future technology may provide us with means to diagnose th... | New and future techniques in prenatal diagnosis. Fetal evaluation may be accomplished in the future using techniques experimental at this time. These include direct visualization of the fetus by endoscopy, biopsy of fetal tissues, and indirect techniques accomplished in the laboratory. It is hoped that in the future te... | [
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PMID:15889 | Disappearance of para-amino-hippurate from amniotic fluid. | Eight pregnant women and three pregnant sheep received 400 mg of para-amino-hippurate (PAH) intraaminotically. Serial samples of amniotic fluid and maternal blood were obtained. In sheep samples of fetal blood were also withdrawn. PAH appeared in maternal plasma in all the cases. In all pregnant women PAH disappeared s... | Disappearance of para-amino-hippurate from amniotic fluid. Eight pregnant women and three pregnant sheep received 400 mg of para-amino-hippurate (PAH) intraaminotically. Serial samples of amniotic fluid and maternal blood were obtained. In sheep samples of fetal blood were also withdrawn. PAH appeared in maternal plasm... | [
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PMID:15890 | Antepartum fetal arrythmia. A case report. | On a number of occasions fetal heart arrythmias have been detected during the course of routine antepartum patient examination. A case is presented to illustrate the difficulty of making a definitive diagnosis of the nature of the arrythmia, and its significance in relation to fetal status. Investigation included stres... | Antepartum fetal arrythmia. A case report. On a number of occasions fetal heart arrythmias have been detected during the course of routine antepartum patient examination. A case is presented to illustrate the difficulty of making a definitive diagnosis of the nature of the arrythmia, and its significance in relation to... | [
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PMID:15891 | The estimation of gestational age by amniotic fluid analysis and its relationship to fetal growth retardation. | The relationship between three amniotic fluid parameters (fat staining cells, anucleate cells and creatinine) and gestational age has been studied in 166 samples from 107 patients of known gestational age. Individually there is an unacceptable degree of inaccuracy. However, when the three parameters are combined in a m... | The estimation of gestational age by amniotic fluid analysis and its relationship to fetal growth retardation. The relationship between three amniotic fluid parameters (fat staining cells, anucleate cells and creatinine) and gestational age has been studied in 166 samples from 107 patients of known gestational age. Ind... | [
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PMID:15892 | Repeated extra-amniotic administration of prostaglandin F2alpha for midtrimester abortion. | Midtrimester abortion was induced in 94 of 100 patients at 16 to 24 weeks' gestation by the extra-amniotic administration of 1170 microng of prostaglandin F2alpha (PGF2alpha) every 10 minutes. The number of prostaglandin doses varied from 16 to 24 depending on the patient's response to the prostaglandin. The median abo... | Repeated extra-amniotic administration of prostaglandin F2alpha for midtrimester abortion. Midtrimester abortion was induced in 94 of 100 patients at 16 to 24 weeks' gestation by the extra-amniotic administration of 1170 microng of prostaglandin F2alpha (PGF2alpha) every 10 minutes. The number of prostaglandin doses va... | [
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PMID:15893 | Pregnancies in the presence of copper intra-uterine devices. Hysterosalpingographic studies. | Two copper-bearing intrauterine devices--the Cu-7 and Cu-T-200--were investigated to determine why contraceptive failures occur with these devices. For this investigation, 155 multiparous women were followed up for at least 24 months after IUD insertion (T-Cu-200 in 75 cases and the Cu-7 in 80 cases). Three women using... | Pregnancies in the presence of copper intra-uterine devices. Hysterosalpingographic studies. Two copper-bearing intrauterine devices--the Cu-7 and Cu-T-200--were investigated to determine why contraceptive failures occur with these devices. For this investigation, 155 multiparous women were followed up for at least 24 ... | [
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PMID:15894 | Estrogen-progesterone withdrawal bleeding in diagnosis of early pregnancy. | This study was designed to evaluate the efficacy of an exogenous estrogen-progesterone preparation for inducing "withdrawal bleeding" in non-pregnant women, a procedure used in some areas for the diagnosis of early pregnancy. Three hundred patients not desiring to be pregnant and with no signs of pregnancy other than m... | Estrogen-progesterone withdrawal bleeding in diagnosis of early pregnancy. This study was designed to evaluate the efficacy of an exogenous estrogen-progesterone preparation for inducing "withdrawal bleeding" in non-pregnant women, a procedure used in some areas for the diagnosis of early pregnancy. Three hundred patie... | [
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PMID:15895 | Carcinoma in situ of the Fallopian tube associated with cervical carcinoma. Case report. | A case of carcinoma in situ of the fallopian tube in a 55-year-old woman, associated to cervical carcinoma is described. The necessary criteria for the diagnosis of pre-invasive carcinoma of the fallopian tube, among which the number of mitoses seems to be of great importance, are discussed. This previously unreported ... | Carcinoma in situ of the Fallopian tube associated with cervical carcinoma. Case report. A case of carcinoma in situ of the fallopian tube in a 55-year-old woman, associated to cervical carcinoma is described. The necessary criteria for the diagnosis of pre-invasive carcinoma of the fallopian tube, among which the numb... | [
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PMID:15896 | A transcutaneous PO2 electrode for continuous monitoring of fetal state during delivery. | A transcutaneous PO2 electrode has been designed and constructed for the continuous measurement of fetal oxygen tension during labor and delivery. The electrode, tested in vitro, has a low oxygen consumption, a short response time, 10 sec, and a sufficient stability, 5% over 3 hr. The in vivo performance of the electro... | A transcutaneous PO2 electrode for continuous monitoring of fetal state during delivery. A transcutaneous PO2 electrode has been designed and constructed for the continuous measurement of fetal oxygen tension during labor and delivery. The electrode, tested in vitro, has a low oxygen consumption, a short response time,... | [
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PMID:15897 | A new technique and instruments for delivery of the Fallopian tube in female sterilization. | This report describes an instrument designed for locating and delivering the Fallopian tube through an incision of less than 2 cm. Since no gas insufflation, fibre optic illumination, or electricity is required for successful use of this instrument, it is well suited for performing outpatient tubal sterilizations in ar... | A new technique and instruments for delivery of the Fallopian tube in female sterilization. This report describes an instrument designed for locating and delivering the Fallopian tube through an incision of less than 2 cm. Since no gas insufflation, fibre optic illumination, or electricity is required for successful us... | [
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PMID:15898 | The effect of indomethacin in labour at term. | The effect of indomethacin as an antagonist to prostaglandin was evaluated on a series of 16 women during spontaneous labour in the ninth month of pregnancy. The evaluation of the effect of indomethacin on the progression of labour was determined by the deviation from the normal curve of Friedman. In 8 cases there was ... | The effect of indomethacin in labour at term. The effect of indomethacin as an antagonist to prostaglandin was evaluated on a series of 16 women during spontaneous labour in the ninth month of pregnancy. The evaluation of the effect of indomethacin on the progression of labour was determined by the deviation from the n... | [
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PMID:15899 | Iron deficiency anaemia in Nigerian pregnant women. | Ninety-four Nigerian pregnant women, many of who had mild to moderate anaemia, were investigated for the presence of iron deficiency. Using the bone marrow as the diagnostic index, 90% of these patients were found to be iron deficient. Iron deficiency is thus common among our expectant mothers. They should, therefore, ... | Iron deficiency anaemia in Nigerian pregnant women. Ninety-four Nigerian pregnant women, many of who had mild to moderate anaemia, were investigated for the presence of iron deficiency. Using the bone marrow as the diagnostic index, 90% of these patients were found to be iron deficient. Iron deficiency is thus common a... | [
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PMID:15900 | A suggested set of working definitions and criteria applicable to induction of labour. | A list of prerequisites, essential items of information and definitions applying to studies on induction of labour is presented. It is suggested that their use would permit proper analysis and comparison of results obtained by different investigators. | A suggested set of working definitions and criteria applicable to induction of labour. A list of prerequisites, essential items of information and definitions applying to studies on induction of labour is presented. It is suggested that their use would permit proper analysis and comparison of results obtained by differ... | [
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PMID:15901 | Endometrial control: a comparative study of three oral contraceptives. | Shortly after completing an OC cycle the relative hormonal deficit caused by discontinuing the hormones results in withdrawal bleeding. Similarly, if one or more oral contraceptive tablets are missed during a cycle, the resulting deficiency may cause breakthrough bleeding. A lower incidence of breakthrough bleeding on ... | Endometrial control: a comparative study of three oral contraceptives. Shortly after completing an OC cycle the relative hormonal deficit caused by discontinuing the hormones results in withdrawal bleeding. Similarly, if one or more oral contraceptive tablets are missed during a cycle, the resulting deficiency may caus... | [
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PMID:15902 | Minilaparotomy for female sterilization: a feasibility study of a new technique. | Female sterilization via a minilaparotomy incision was performed on 30 patients at Al-Azhar University Teaching Hospital in Cairo, Egypt. A uterine sound fed through a Foley catheter was used as a uterine elevator. A 2 cm suprapubic transverse laparotomy was performed and sterilization was accomplished by fimbriectomy.... | Minilaparotomy for female sterilization: a feasibility study of a new technique. Female sterilization via a minilaparotomy incision was performed on 30 patients at Al-Azhar University Teaching Hospital in Cairo, Egypt. A uterine sound fed through a Foley catheter was used as a uterine elevator. A 2 cm suprapubic transv... | [
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PMID:15903 | Midtrimester abortion: a comparison of intraamniotic prostaglandin F2alpha and hypertonic saline. | The safety and effectiveness of two intraamniotic prostaglandin F2alpha (PGF2alpha) dose schedules (a single 50 mg dose and a repeated 25 mg dose) and intraamniotic hypertonic saline were evaluated in a study where each abortion procedure was randomly assigned to 50 patients. All patients were at 16 to 20 weeks' gestat... | Midtrimester abortion: a comparison of intraamniotic prostaglandin F2alpha and hypertonic saline. The safety and effectiveness of two intraamniotic prostaglandin F2alpha (PGF2alpha) dose schedules (a single 50 mg dose and a repeated 25 mg dose) and intraamniotic hypertonic saline were evaluated in a study where each ab... | [
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PMID:15904 | An assessment of the side effects of switching from one oral contraceptive to another. | Side effects associated with three oral contraceptives were evaluated in a study in which women were switched to Norlestrin 1 from either Ovral (64 subjects) or Norinyl 1/50 (26 subjects). In the cycle prior to crossover, breast discomfort was more frequent among Norinyl users than among Ovral users. The prevalence of ... | An assessment of the side effects of switching from one oral contraceptive to another. Side effects associated with three oral contraceptives were evaluated in a study in which women were switched to Norlestrin 1 from either Ovral (64 subjects) or Norinyl 1/50 (26 subjects). In the cycle prior to crossover, breast disc... | [
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PMID:15905 | Practicability of ultrasonography for assessing fetal age and weight in early pregnancy. | This study was conducted to evaluate (1) the feasibility and accuracy of the B-Scan technique for measuring biparietal diameter (BPD) in utero, (2) the accuracy of the B-Scan technique for predicting fetal age and weight, and (3) parameters of fetal growth in pregnancies of less than 21 weeks's gestation. Forty-one sub... | Practicability of ultrasonography for assessing fetal age and weight in early pregnancy. This study was conducted to evaluate (1) the feasibility and accuracy of the B-Scan technique for measuring biparietal diameter (BPD) in utero, (2) the accuracy of the B-Scan technique for predicting fetal age and weight, and (3) p... | [
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PMID:15906 | Laparoscopic sterilization in the puerperium: a review of international experience. | The feasibility of using laparoscopic techinques for pueperal sterilization has been demonstrated on three continents. While the operation is not suggested to replace all other methods of pueperal sterilization, it is advantageous in selected situations. | Laparoscopic sterilization in the puerperium: a review of international experience. The feasibility of using laparoscopic techinques for pueperal sterilization has been demonstrated on three continents. While the operation is not suggested to replace all other methods of pueperal sterilization, it is advantageous in se... | [
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PMID:15907 | A comparative study of electrocoagulation and tubal rings for tubal occlusion at laparoscopy. | The surgical and early postoperative complications and complaints associated with laparoscopic sterilization using electrocoagulation or tubal rings for tubal occlusion were evaluated in a comparative study. Procedures were randomly assigned to subjects (electrocoagulation to 151 subjects and tubal rings to 148 subject... | A comparative study of electrocoagulation and tubal rings for tubal occlusion at laparoscopy. The surgical and early postoperative complications and complaints associated with laparoscopic sterilization using electrocoagulation or tubal rings for tubal occlusion were evaluated in a comparative study. Procedures were ra... | [
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PMID:15908 | Prophylactic antibiotic in elective gynaecological and obstetrical major surgery. | A prospective controlled study of 580 patients who underwent non-radical major gynaecological or obstetrical surgery examined the use of prophylactic antibiotics. The test group of patients (290) showed a significantly lower (P=0.01) incidence of the total complications and the non-infective complication rate as agains... | Prophylactic antibiotic in elective gynaecological and obstetrical major surgery. A prospective controlled study of 580 patients who underwent non-radical major gynaecological or obstetrical surgery examined the use of prophylactic antibiotics. The test group of patients (290) showed a significantly lower (P=0.01) inci... | [
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PMID:15909 | Ossification centers as evidence of fetal lung maturity. | Fetal pulmonary maturity based on visualization of one or both fetal knee secondary centers of ossification was assessed in 84 gravidas. Amniotic fluid lecithin/sphingomyelin ration of 2:1 or greater was the criterion of fetal lung maturity. It was concluded that when antenatal radiographs reveal the presence of both c... | Ossification centers as evidence of fetal lung maturity. Fetal pulmonary maturity based on visualization of one or both fetal knee secondary centers of ossification was assessed in 84 gravidas. Amniotic fluid lecithin/sphingomyelin ration of 2:1 or greater was the criterion of fetal lung maturity. It was concluded that... | [
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PMID:15910 | A comparative study of hysterosalpingography and laparoscopy in the investigation of infertility. | A comparison of hysterosalpingography and laparoscopy was carried out on 79 infertile women. Out of these, 60 had abnormal and 19 had normal hysterosalpingograms. Of the 19 patients with normal X-rays, nine (47%) had abnormal findings during laparoscopy. In 62% of patients with abnormal hysterosalpingograms, laparoscop... | A comparative study of hysterosalpingography and laparoscopy in the investigation of infertility. A comparison of hysterosalpingography and laparoscopy was carried out on 79 infertile women. Out of these, 60 had abnormal and 19 had normal hysterosalpingograms. Of the 19 patients with normal X-rays, nine (47%) had abnor... | [
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PMID:15911 | Morphologic studies on the non-cancerous cervix in Jamaicans at different ages. | A morphologic investigation on 100 cervices removed at autopsy from negro Jamaican women at different ages showed that columnar epithelium was frequently located on the portio vaginalis at all ages. The absence of this phenomenon in some fetal cervices supports the hypothesis of embryologic displacement rather than sti... | Morphologic studies on the non-cancerous cervix in Jamaicans at different ages. A morphologic investigation on 100 cervices removed at autopsy from negro Jamaican women at different ages showed that columnar epithelium was frequently located on the portio vaginalis at all ages. The absence of this phenomenon in some fe... | [
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PMID:15912 | A technique for the induction of labor by the extraovular administration of prostaglandin F2alpha. | Prostaglandin F2alpha (PG F2alpha) was administered to pregnant women at a dosage of 50 microng or 100 microng by extraovular route around the expected time of childbirth in order to induce labor. (1) PG F2alpha 50 microng or 100 microng dissolved in 10 ml of physiological saline solution was infused by extraovular adm... | A technique for the induction of labor by the extraovular administration of prostaglandin F2alpha. Prostaglandin F2alpha (PG F2alpha) was administered to pregnant women at a dosage of 50 microng or 100 microng by extraovular route around the expected time of childbirth in order to induce labor. (1) PG F2alpha 50 micron... | [
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PMID:15913 | Plasma estradiol-17 beta as an index of fetoplacental function. | Serial plasma unconjugated estradiol-17 beta was measured by a radioimmunoassay method in 26 cases of hypertensive disorder of pregnancy, 13 cases of poor obstetric history and 4 cases of intra-uterine growth retardation. There was considerable overlap of hormonal values between pregnancies, resulting in delivery of no... | Plasma estradiol-17 beta as an index of fetoplacental function. Serial plasma unconjugated estradiol-17 beta was measured by a radioimmunoassay method in 26 cases of hypertensive disorder of pregnancy, 13 cases of poor obstetric history and 4 cases of intra-uterine growth retardation. There was considerable overlap of ... | [
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PMID:15914 | Studies on maternal mortality in Mexico. | The sociocultural, psychological, and medical effects of maternal death are described and analyzed for the purpose of appraising the value of the given death as a measure of the quality of medical care. The work of the Maternal Mortality Committee of the Hospital de Gineco-Obstetetricia No. 1 of the Mexican Social Secu... | Studies on maternal mortality in Mexico. The sociocultural, psychological, and medical effects of maternal death are described and analyzed for the purpose of appraising the value of the given death as a measure of the quality of medical care. The work of the Maternal Mortality Committee of the Hospital de Gineco-Obste... | [
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PMID:15915 | Response of fetal acid--base balance to duration of second stage of labour. | Data from 4081 vaginal deliveries (no caesarean sections) were analyzed retrospectively (IBM 730/158) with regard to duration of second and "final stage" of labour and fetal outcome (acid-base balance and apgar scores). The average duration of the two periods amounted to 22.8+/-29.6 and 9.9+/-7.8 min. Mean pH (UA) was ... | Response of fetal acid--base balance to duration of second stage of labour. Data from 4081 vaginal deliveries (no caesarean sections) were analyzed retrospectively (IBM 730/158) with regard to duration of second and "final stage" of labour and fetal outcome (acid-base balance and apgar scores). The average duration of ... | [
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PMID:15916 | Ectopic pregnancy in southern Iran: a statistical review of 96 cases. | A review is presented of 96 cases of ectopic pregnacy over a 7-year period. It is noted that in recent years the incidence of this problem has increased. Inadequately diagnosed and treated pelvic inflammatory disease has been found to be the main predisposing factor (40%). The rate of extra-uterine gestation was 1:336 ... | Ectopic pregnancy in southern Iran: a statistical review of 96 cases. A review is presented of 96 cases of ectopic pregnacy over a 7-year period. It is noted that in recent years the incidence of this problem has increased. Inadequately diagnosed and treated pelvic inflammatory disease has been found to be the main pre... | [
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PMID:15917 | Pyometra. | Thirteen cases of pyometra without preoperative diagnosis in which vaginal or abdominal surgery was performed, are analysed in the present paper. The histologic examination revealed endocervicitis in all cases, while positive cultures for bacteria were found preoperatively in only eight of the above cases, thus, pyomet... | Pyometra. Thirteen cases of pyometra without preoperative diagnosis in which vaginal or abdominal surgery was performed, are analysed in the present paper. The histologic examination revealed endocervicitis in all cases, while positive cultures for bacteria were found preoperatively in only eight of the above cases, th... | [
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