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PMID:16481 | Studies on the pathogenesis of diet-induced dog gallstones. | Experimental diet-induced dog gallstones contained mainly protein, mucous substances, bile salts, bilirubin, an insoluble pigment which formed an insoluble black residue after acid hydrolysis, and only traces of cholesterol. Added dietary cholesterol was necessary to pigmented gallstone production and led to hyperchole... | Studies on the pathogenesis of diet-induced dog gallstones. Experimental diet-induced dog gallstones contained mainly protein, mucous substances, bile salts, bilirubin, an insoluble pigment which formed an insoluble black residue after acid hydrolysis, and only traces of cholesterol. Added dietary cholesterol was neces... | [
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PMID:16482 | Absorption of short-chain fatty acids from the human ileum. | Acetate, propionate, and n-butyrate are the major short-chain fatty acid (SCFA) anions in the gastrointestinal tract of animal and man, accounting for 90% of total SCFA in stool water. Their absorption from the human ileum was investigated in 8 volunteer subjects by the triple-lumen perfusion technique. Each test solut... | Absorption of short-chain fatty acids from the human ileum. Acetate, propionate, and n-butyrate are the major short-chain fatty acid (SCFA) anions in the gastrointestinal tract of animal and man, accounting for 90% of total SCFA in stool water. Their absorption from the human ileum was investigated in 8 volunteer subje... | [
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PMID:16483 | Esophageal intraluminal pH recording in the assessment of gastroesophageal reflux and its consequences. | Intraluminal pH in the lower esophagus has been recorded during a 3-hr period following a ligh meal and a consecutive 12-hr nocturnal period in 20 patients with typical symptoms and radiological evidence of gastroesophageal reflux and in 10 patients without such signs of reflux. Evidence of acid reflux was obtained in ... | Esophageal intraluminal pH recording in the assessment of gastroesophageal reflux and its consequences. Intraluminal pH in the lower esophagus has been recorded during a 3-hr period following a ligh meal and a consecutive 12-hr nocturnal period in 20 patients with typical symptoms and radiological evidence of gastroeso... | [
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PMID:16484 | Effects of parenteral secretin--cholecystokinin and of duodenal acid perfusion on gastric secretion in duodenal ulcer patients. | The effect of parenteral secretin-cholecystokinin and duodenal acid perfusion on broth-stimulated gastric acid secretion was studied in 11 duodenal ulcer patients. Statistically significant inhibition occurred in both experimental conditions. The effect of secretin-cholecystokinin was more marked than the effect of duo... | Effects of parenteral secretin--cholecystokinin and of duodenal acid perfusion on gastric secretion in duodenal ulcer patients. The effect of parenteral secretin-cholecystokinin and duodenal acid perfusion on broth-stimulated gastric acid secretion was studied in 11 duodenal ulcer patients. Statistically significant in... | [
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PMID:16488 | Antimicrobial and other properties of a new stabilized alkaline glutaraldehyde disinfectant/sterilizer. | The properties of stabilized alkaline 2% glutaraldehyde solution (SGS) are discussed. SGS is discussed with regard to its chemistry, antimicrobial properties, organic soil resistance, toxicity, corrosivity and chemical stability. SGS retains the maximum antimicrobial activity of alkaline glutaraldehyde solutions and th... | Antimicrobial and other properties of a new stabilized alkaline glutaraldehyde disinfectant/sterilizer. The properties of stabilized alkaline 2% glutaraldehyde solution (SGS) are discussed. SGS is discussed with regard to its chemistry, antimicrobial properties, organic soil resistance, toxicity, corrosivity and chemic... | [
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PMID:16489 | Propoxyphene: a review. | A critical analysis of information on propoxyphene that has been published since the drug's introduction is presented. Propoxyphene is discussed with regard to its chemistry, metabolism and pharmacokinetics, analgesic efficacy, analgesic efficacy of combination products, nonanalgesic uses, adverse effects, overdosage, ... | Propoxyphene: a review. A critical analysis of information on propoxyphene that has been published since the drug's introduction is presented. Propoxyphene is discussed with regard to its chemistry, metabolism and pharmacokinetics, analgesic efficacy, analgesic efficacy of combination products, nonanalgesic uses, adver... | [
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PMID:16490 | Immune complexes in hepatitis B antigen-associated periarteritis nodosa. Detection by antibody-dependent cell-mediated cytotoxicity and the Raji cell assay. | A subpopulation of peripheral blood lymphocytes with the ability to lyse target cells coated with specific antibody (antibody-dependent cell-mediated cytotoxicity, ADCC) was serially studied in a patient with hepatitis B antigen-associated periarteritis nodosa. The effector lymphocytes possess FC and complement recepto... | Immune complexes in hepatitis B antigen-associated periarteritis nodosa. Detection by antibody-dependent cell-mediated cytotoxicity and the Raji cell assay. A subpopulation of peripheral blood lymphocytes with the ability to lyse target cells coated with specific antibody (antibody-dependent cell-mediated cytotoxicity,... | [
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PMID:16491 | Bilateral atrial myxomas with multiple arterial aneurysms--a syndrome mimicking polyarteritis nodosa. | This patient, previously described as having polyarteritis nodosa with multiple aneurysms shown by angiography, was recently found to have bilateral atrial myxomas. The angiographic demonstration of multiple cerebral aneurysms has been described in a few cases of left atrial myxoma. This uncommon tumor is also accompan... | Bilateral atrial myxomas with multiple arterial aneurysms--a syndrome mimicking polyarteritis nodosa. This patient, previously described as having polyarteritis nodosa with multiple aneurysms shown by angiography, was recently found to have bilateral atrial myxomas. The angiographic demonstration of multiple cerebral a... | [
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PMID:16492 | Gonadotropin receptors in human corpora lutea of the menstrual cycle and pregnancy. | Binding of 125I-human choriogonadotropin (hCG) to homogenates of corpora lutea of the menstrual cycle and pregnancy was examined. While corpora lutea of the menstrual cycle bound 125I-hCG, most of the corpora lutea of pregnancy from six to 34 weeks' gestation bound little or none of the added 125 I-hCG. Further explora... | Gonadotropin receptors in human corpora lutea of the menstrual cycle and pregnancy. Binding of 125I-human choriogonadotropin (hCG) to homogenates of corpora lutea of the menstrual cycle and pregnancy was examined. While corpora lutea of the menstrual cycle bound 125I-hCG, most of the corpora lutea of pregnancy from six... | [
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PMID:16493 | Effect of fenoterol (Th1165a) infusion on uterine and umbilical blood flow in pregnant sheep. | The effect of fenoterol (Th1165a) upon uterine artery blood flow (UtBF) and umbilical vein blood flow (UmBF) was investigated in near-term, nonlaboring chronic sheep preparations. During intravenous fenoterol infusions to the ewe in either incremental doses from 0.025 to 0.200 microng per kilogram per minute or constan... | Effect of fenoterol (Th1165a) infusion on uterine and umbilical blood flow in pregnant sheep. The effect of fenoterol (Th1165a) upon uterine artery blood flow (UtBF) and umbilical vein blood flow (UmBF) was investigated in near-term, nonlaboring chronic sheep preparations. During intravenous fenoterol infusions to the ... | [
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PMID:16494 | The effect of umbilical vein occlusion on fetal oxygenation, cardiovascular parameters, and fetal electroencephalogram. | In 11 fetal sheep experiments, the blood pressure in the fetal aorta (FA) and in the umbilical vein (UV) was measured following umbilical vein occlusion (UVO), as was the fetal heart rate (FHR), pH, Pco2, and oxygen saturation (So2) in both fetal vessels, and umbilical blood flow (Qumb) of the common UV. The fetal elec... | The effect of umbilical vein occlusion on fetal oxygenation, cardiovascular parameters, and fetal electroencephalogram. In 11 fetal sheep experiments, the blood pressure in the fetal aorta (FA) and in the umbilical vein (UV) was measured following umbilical vein occlusion (UVO), as was the fetal heart rate (FHR), pH, P... | [
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PMID:16495 | Cardiovascular effects of fever in the ewe and fetal lamb. | Ewes carrying fetuses with permanently implanted cannulas developed fevers following intravenous injections of bacterial pyrogen (1 microng). During the rising phase of the fever, maternal heart rate increased, but no consistent changes in mean arterial blood pressure (MABP), arterial pH, PO2, or PCO2 were observed dur... | Cardiovascular effects of fever in the ewe and fetal lamb. Ewes carrying fetuses with permanently implanted cannulas developed fevers following intravenous injections of bacterial pyrogen (1 microng). During the rising phase of the fever, maternal heart rate increased, but no consistent changes in mean arterial blood p... | [
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PMID:16497 | Na+-K+-ATPase inhibition stimulates PGE release in guinea pig taenia coli. | Inhibition of the plasma membrane enzyme Na+-K+-ATPase by ouabain zero extracellular K+, or low extracellular Na+, markedly augmented prostaglandin E release from the guinea pig taenia coli. Data suggest this phenomenon may be linked directly to Na+-K+-ATPase or Na+ pump activities, or changes in intracellular K+ conce... | Na+-K+-ATPase inhibition stimulates PGE release in guinea pig taenia coli. Inhibition of the plasma membrane enzyme Na+-K+-ATPase by ouabain zero extracellular K+, or low extracellular Na+, markedly augmented prostaglandin E release from the guinea pig taenia coli. Data suggest this phenomenon may be linked directly to... | [
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PMID:16498 | Vitamin A1 intestinal absorption in vivo: influence of luminal factors on transport. | Intestinal absorption of [3H]retinol was studied in the unanesthetized rat. Luminal perfusate was recirculated through isolated intestinal segments with intact vascular and lymphatic circulation. Apparent saturation kinetics were found in physiological concentrations of retinol, whereas a linear relationship between th... | Vitamin A1 intestinal absorption in vivo: influence of luminal factors on transport. Intestinal absorption of [3H]retinol was studied in the unanesthetized rat. Luminal perfusate was recirculated through isolated intestinal segments with intact vascular and lymphatic circulation. Apparent saturation kinetics were found... | [
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PMID:16499 | Effect of chronic furosemide administration on hydrogen and sodium excretion in the dog. | Studies were performed to evaluate the effects of the chronic administration of furosemide on hydrogen and electrolyte excretion in dogs on a normal electrolyte diet and in the absence of electrolyte or volume depletion. Control daily excretion in five dogs averaged 64 meq for Na, 51 meq for K, 66 meq for Cl, and 17 me... | Effect of chronic furosemide administration on hydrogen and sodium excretion in the dog. Studies were performed to evaluate the effects of the chronic administration of furosemide on hydrogen and electrolyte excretion in dogs on a normal electrolyte diet and in the absence of electrolyte or volume depletion. Control da... | [
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PMID:16500 | Effect of parathyroid hormone on urinary acidification. | The effect of parathyroid hormone (PTH) administration on urinary acidification was studied in intact and thyroparathyroidectomized dogs. PTH administration resulted in a significant increase in urine pH and HCO3 excretion. In dogs with maximally acid urine caused by Na2SO4 infusion PTH administration also led to a sig... | Effect of parathyroid hormone on urinary acidification. The effect of parathyroid hormone (PTH) administration on urinary acidification was studied in intact and thyroparathyroidectomized dogs. PTH administration resulted in a significant increase in urine pH and HCO3 excretion. In dogs with maximally acid urine caused... | [
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PMID:16501 | Distribution of adenine nucleotides in the perfused rat heart. | A computer technique for determination of the distribution of adenine nucleotides among compartmented, protonated, and metal-chelated species has been developed for the perfused rat heart. This procedure requires knowledge of tissue levels of creatine, creatine phosphate, ATP, ADP, and AMP and the glycolytic and respir... | Distribution of adenine nucleotides in the perfused rat heart. A computer technique for determination of the distribution of adenine nucleotides among compartmented, protonated, and metal-chelated species has been developed for the perfused rat heart. This procedure requires knowledge of tissue levels of creatine, crea... | [
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PMID:16502 | Computer simulation of energy metabolism in anoxic perfused rat heart. | We have modeled the energy metabolism of the perfused rat heart in order to elucidate the interaction of physiological and biochemical control mechanisms. This model which includes glycolysis, the Krebs cycle, and related metabolism, contains 68 submodels of individual enzymes and transport mechanisms including both cy... | Computer simulation of energy metabolism in anoxic perfused rat heart. We have modeled the energy metabolism of the perfused rat heart in order to elucidate the interaction of physiological and biochemical control mechanisms. This model which includes glycolysis, the Krebs cycle, and related metabolism, contains 68 sub... | [
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PMID:16503 | Computer simulation of rat heart metabolism after adding glucose to the perfusate. | An experiment where perfused rat hearts receiving no substrate are suddenly given glucose with insulin in the perfusate is simulated with a computer model of cardiac energy metabolism. Mitochondrial metabolism is quantitatively reorganized under cytoplasmic control, with fatty acid oxidation undergoing a two-step decre... | Computer simulation of rat heart metabolism after adding glucose to the perfusate. An experiment where perfused rat hearts receiving no substrate are suddenly given glucose with insulin in the perfusate is simulated with a computer model of cardiac energy metabolism. Mitochondrial metabolism is quantitatively reorganiz... | [
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PMID:16504 | Relationship between gastric mucosal pH and site of peptic ulceration. | Measurements of mucosal pH of resected stomachs were carried out in gastric and duodenal ulcer patients. Low mucosal pH along the lesser curvature and relatively higher gastric pepsin levels were found. It is suggested that this lower pH affects gastric ulcer occurrence in the limited "lesser curvature area" where 63 p... | Relationship between gastric mucosal pH and site of peptic ulceration. Measurements of mucosal pH of resected stomachs were carried out in gastric and duodenal ulcer patients. Low mucosal pH along the lesser curvature and relatively higher gastric pepsin levels were found. It is suggested that this lower pH affects gas... | [
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PMID:16506 | The role of analgesics in respiratory depression: a rabbit model. | The study of the effect of analgesics in the newborn is difficult in the clinical situation and resort must be made to animals. Pethidine given within 1 hour of delivery is believed to cause less depression than when the time interval is longer. This study investigates whether it is pethidine or its metabolites which c... | The role of analgesics in respiratory depression: a rabbit model. The study of the effect of analgesics in the newborn is difficult in the clinical situation and resort must be made to animals. Pethidine given within 1 hour of delivery is believed to cause less depression than when the time interval is longer. This stu... | [
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PMID:16507 | Formaldehyde formation as a metabolite of methoxyflurane. | The production of formaldehyde as a metabolite of enzymatic biotransformation of methoxyflurane was observed in vitro in hepatic microsomal preparations derived from Japanese monkeys, rabbits and Wistar strain rats. Production rates of formaldehyde were 0.80-2.50 n moles/mg protein/min in the induced group which was pr... | Formaldehyde formation as a metabolite of methoxyflurane. The production of formaldehyde as a metabolite of enzymatic biotransformation of methoxyflurane was observed in vitro in hepatic microsomal preparations derived from Japanese monkeys, rabbits and Wistar strain rats. Production rates of formaldehyde were 0.80-2.5... | [
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PMID:16508 | [Anaesthesia with flunitrazepam (rohypnol) and fentanyl for geriatric patients (author's transl)]. | Favorable clinic experiences with an anaesthetic involving rohypnol (flunitrazepam) and fentanyl led to an investigation of the haemodynamic effect of this procedure in a group of 9 geriatric patients, aged from 86 to 95 years. Anaesthesia was induced with 0.5 mg rohypnol and 0.1 to 0.2 mg fentanyl depending on the nar... | [Anaesthesia with flunitrazepam (rohypnol) and fentanyl for geriatric patients (author's transl)]. Favorable clinic experiences with an anaesthetic involving rohypnol (flunitrazepam) and fentanyl led to an investigation of the haemodynamic effect of this procedure in a group of 9 geriatric patients, aged from 86 to 95 ... | [
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PMID:16509 | [Paresis of the tympanic nerve--a rare complication of spinal anesthesia (author's transl)]. | Acut impairment of hearing following spinal anaesthesia is described. The cause, treatment of and incidence rate of neurological complications of spinal anaesthesia are discussed. | [Paresis of the tympanic nerve--a rare complication of spinal anesthesia (author's transl)]. Acut impairment of hearing following spinal anaesthesia is described. The cause, treatment of and incidence rate of neurological complications of spinal anaesthesia are discussed. | [
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PMID:16512 | Alpha-adrenergic blocking action of fentanyl on the isolated aorta of the rabbit. | The contractile response of helically-cut strips of rabbit ascending aorta to transmural electrical stimulation was attenuated in a dose-dependent manner by treatment for 20 min with fentanyl, 10(-6) to 10(-5) M. Fentanyl also shifted the dose-response curve of the contractile response of aorta to norepinephrine to the... | Alpha-adrenergic blocking action of fentanyl on the isolated aorta of the rabbit. The contractile response of helically-cut strips of rabbit ascending aorta to transmural electrical stimulation was attenuated in a dose-dependent manner by treatment for 20 min with fentanyl, 10(-6) to 10(-5) M. Fentanyl also shifted the... | [
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PMID:16511 | The splitting of sperm heads from tails in eight mammalian species and the measurement of their sizes. | Ejaculated spermatozoa from man, the Euopean wild boar and the bull, and spermatozoa from the cauda epididymes of the rabbit, rat, mouse, hamster and Guinea pig were treated with a sonic bath, a sonic probe, trypsin with and without prior treatment with a sulphhydryl reagent, pronase and alkalis. The fragments produced... | The splitting of sperm heads from tails in eight mammalian species and the measurement of their sizes. Ejaculated spermatozoa from man, the Euopean wild boar and the bull, and spermatozoa from the cauda epididymes of the rabbit, rat, mouse, hamster and Guinea pig were treated with a sonic bath, a sonic probe, trypsin w... | [
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PMID:16518 | [Membrane oxygenators in cardiac surgery: progress]. | This study tries to define if the membrane oxygenators are available during cardiac surgery under E.C.C., and if their performance are superior to those of conventional oxygenators. Two series of research are done. In the first one, we compare performance of two membrane oxygenators: the Rhône-Poulenc heart-lung machin... | [Membrane oxygenators in cardiac surgery: progress]. This study tries to define if the membrane oxygenators are available during cardiac surgery under E.C.C., and if their performance are superior to those of conventional oxygenators. Two series of research are done. In the first one, we compare performance of two memb... | [
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PMID:16519 | [Methods of sampling and preservation of blood used during extracorporeal circulation]. | The blood supply of Cardiac Surgery Centers set quantitative and qualitative problems to the Centers of blood dispatch. In this work, from a Lyonese experience on 4,000 E.C.C., authors try to define the best preservative solution, especially for the respiratory function of the red blood cell. The C.P.D. solution (citra... | [Methods of sampling and preservation of blood used during extracorporeal circulation]. The blood supply of Cardiac Surgery Centers set quantitative and qualitative problems to the Centers of blood dispatch. In this work, from a Lyonese experience on 4,000 E.C.C., authors try to define the best preservative solution, e... | [
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PMID:16520 | [Value of using cell concentrates, preserved by freezing, during extracorporeal circulation]. | The effectiveness of transfusions of frozen red cells has presently been clearly demonstrated. The authors present their technique of preparation of these cells and their experience of this material in 51 cases of ECC. The results observed plead in favour of the notion that frozen-defrosted blood, combines the advantag... | [Value of using cell concentrates, preserved by freezing, during extracorporeal circulation]. The effectiveness of transfusions of frozen red cells has presently been clearly demonstrated. The authors present their technique of preparation of these cells and their experience of this material in 51 cases of ECC. The res... | [
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PMID:16521 | [Technics, value and limitations of hemodilution in extracorporeal circulation]. | Hemodilution during E.C.C. is into use for more than 15 years. Its interest is obvious (blood economy, beneficient action on viscosity, prevention of "sludging"), but opinions are different concerning the best level of hemodiultion. The authors defend the notion of a moderate dilution (hematocrit larger than or equal t... | [Technics, value and limitations of hemodilution in extracorporeal circulation]. Hemodilution during E.C.C. is into use for more than 15 years. Its interest is obvious (blood economy, beneficient action on viscosity, prevention of "sludging"), but opinions are different concerning the best level of hemodiultion. The au... | [
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PMID:16522 | [Biological aspects of extracorporeal circulation]. | Two problems are looked at in this work. That of glucose which is administered in considerable quantities during ECC and that of the iso-enzymes. The administration of glucose has two aims: one being the mechanical nature i.e. as an agent which decreases the risks of platelet aggregation, the other bio-energetic. But, ... | [Biological aspects of extracorporeal circulation]. Two problems are looked at in this work. That of glucose which is administered in considerable quantities during ECC and that of the iso-enzymes. The administration of glucose has two aims: one being the mechanical nature i.e. as an agent which decreases the risks of ... | [
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PMID:16523 | [Sodium supply in operations under extracorporeal circulation in children]. | In order to explain the edematous appearance found in infants after ECC associated with hyponatremia, the authors studied the supply of sodium per and post-operatively in 42 children aged from 11 days to 13 years undergoing correction of the cardiopathy under ECC. This study enables one to find that there is an inflati... | [Sodium supply in operations under extracorporeal circulation in children]. In order to explain the edematous appearance found in infants after ECC associated with hyponatremia, the authors studied the supply of sodium per and post-operatively in 42 children aged from 11 days to 13 years undergoing correction of the ca... | [
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PMID:16525 | [Hemodynamic parameters which should be watched during and immediately after extracorporeal circulation]. | The author studies only the usual investigations required for watching E.C.C. during the operatory period and directly afterwards. During E.C.C., one must essentially oversee the flow (2,4l/m2 or 70 ml/kg), the arterial pressure (70 torrs) essential factor for myocardiac injection, the C.V.P., where excess is factor of... | [Hemodynamic parameters which should be watched during and immediately after extracorporeal circulation]. The author studies only the usual investigations required for watching E.C.C. during the operatory period and directly afterwards. During E.C.C., one must essentially oversee the flow (2,4l/m2 or 70 ml/kg), the art... | [
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PMID:16526 | [Protection of the myocardium by hypothermia during extracorporeal circulation. Experimental and clinical study]. | Hypothermic protection of myocardia during E.C.C. has been estimated on a 35 dogs experimental series and on a clinical series of 700 acquired cardiopathies of adult, including 400 valvular replacements and 300 aorto-coronary by-pass. Experimental results have been estimated by biochemic and morphologic controls done o... | [Protection of the myocardium by hypothermia during extracorporeal circulation. Experimental and clinical study]. Hypothermic protection of myocardia during E.C.C. has been estimated on a 35 dogs experimental series and on a clinical series of 700 acquired cardiopathies of adult, including 400 valvular replacements and... | [
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PMID:16527 | [Myocardial protection by coronary perfusion and specific problems of myocardial protection in combined valvular and coronary surgery]. | The quality of the myocardial protection by bilateral coronary perfusion was studied in a consecutive series of 80 patients treated by isolated aortic replacements (47 cases) or multiple replacements (mitro-aortic, or mitro-aortic and tricuspid) 33 cases. Four low outputs (5 p. 100) were observed with only one death. F... | [Myocardial protection by coronary perfusion and specific problems of myocardial protection in combined valvular and coronary surgery]. The quality of the myocardial protection by bilateral coronary perfusion was studied in a consecutive series of 80 patients treated by isolated aortic replacements (47 cases) or multip... | [
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PMID:16528 | [Computer analysis of a method of myocardial protection used in a series of 547 operations under extracorporeal circulation in adults]. | During 4 years (1970-1974), the numerous pre, per and post-operative datas collected for each adult operated under E.C.C. by the same surgeon, have been analysed on computer (547 cases). The myocardic protection method was unvariable: steady hypothermia of 30 degrees C, induced ventricular fibrillation, myocardic anoxi... | [Computer analysis of a method of myocardial protection used in a series of 547 operations under extracorporeal circulation in adults]. During 4 years (1970-1974), the numerous pre, per and post-operative datas collected for each adult operated under E.C.C. by the same surgeon, have been analysed on computer (547 cases... | [
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PMID:16529 | [Changes in myocardial tolerance to ischemia as a function of circulatory arrest mechanisms]. | This study tries to specify the tolerance limit of heart to ischemia and has three parts. In the first one, the author considers the heart resistance in normothermy related to the circulatory arrest type, the anesthetic technique, existence or not or a ventricular fibrillation. Everybody is tody in agreement to admit t... | [Changes in myocardial tolerance to ischemia as a function of circulatory arrest mechanisms]. This study tries to specify the tolerance limit of heart to ischemia and has three parts. In the first one, the author considers the heart resistance in normothermy related to the circulatory arrest type, the anesthetic techni... | [
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PMID:16530 | [Neuroplegia and extracorporeal circulation. Comparison between combinations of droperidol-phenoperidine and chlorprothixene-dextromoramide in cardiac surgery]. | After a quick review of the physiopathology of extra-corporeal circulation, the value of the use of neuroplegic drugs in cardiac surgery is recalled by means of pharmacological arguments. The experimental differences existing between the combinations droperidol - phenoperidine and chlorportixene - dextromoramide, on th... | [Neuroplegia and extracorporeal circulation. Comparison between combinations of droperidol-phenoperidine and chlorprothixene-dextromoramide in cardiac surgery]. After a quick review of the physiopathology of extra-corporeal circulation, the value of the use of neuroplegic drugs in cardiac surgery is recalled by means o... | [
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PMID:16531 | [Drug protection of the myocardium during cardiac surgery]. | During aortic clamping, drug protection of the myocardium, far from supplanting hypothermia, complements it, particularly in the case of left ventricular hypertrophy. Ultramicroscopy and new techniques of histobiological exploration of the myocite have enabled one to distinguish the lessions provoked by anoxia from tho... | [Drug protection of the myocardium during cardiac surgery]. During aortic clamping, drug protection of the myocardium, far from supplanting hypothermia, complements it, particularly in the case of left ventricular hypertrophy. Ultramicroscopy and new techniques of histobiological exploration of the myocite have enabled... | [
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PMID:16532 | [Shivering during recovery after cardiac surgery under extracorporeal circulation. Inconveniences and methods of prevention]. | Among 109 subjects who had undergone cardiac surgery under ECC, the authors recorded 50 (45 p. 100) who suffered from shivering during the coming round period. Comparing the series of patients who shivered, with that of the subjects who did not shiver, the authors demonstrate in the first case, an increase in cellular ... | [Shivering during recovery after cardiac surgery under extracorporeal circulation. Inconveniences and methods of prevention]. Among 109 subjects who had undergone cardiac surgery under ECC, the authors recorded 50 (45 p. 100) who suffered from shivering during the coming round period. Comparing the series of patients w... | [
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PMID:16533 | [Preventive treatment of acute renal failure in cardiac surgery]. | The prevention of acute renal failure after cardiac surgery under extracorporeal circulation is possible during the pre-, per- and post-operative phases. During "ECC" the maintenance of "correct" renal perfusion is imperative, the same is also true of the post-operative period; the re-establishment of good hemodynamics... | [Preventive treatment of acute renal failure in cardiac surgery]. The prevention of acute renal failure after cardiac surgery under extracorporeal circulation is possible during the pre-, per- and post-operative phases. During "ECC" the maintenance of "correct" renal perfusion is imperative, the same is also true of th... | [
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PMID:16534 | [Deep hypothermia on the infant: physiopathology and technics of ECC]. | In 81 operations for correction of infants's cardiopathies, authors used, associated with E.C.C., a deep hypothermia allowing a circulatory arrest of an average duration of 52 minutes, according to the technics described by BARRAT-BOYES in 1971. From this experience, authors study the modifications brought to the organ... | [Deep hypothermia on the infant: physiopathology and technics of ECC]. In 81 operations for correction of infants's cardiopathies, authors used, associated with E.C.C., a deep hypothermia allowing a circulatory arrest of an average duration of 52 minutes, according to the technics described by BARRAT-BOYES in 1971. Fro... | [
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PMID:16535 | [Cerebral arterial embolism during extracorporeal circulation]. | From October 1st 1970 to October 1st 1975, electrical and clinical post-operative observation of 1.700 operations under E.C.C. allowed record of E.E.G. and thus study incidents depending of cerebral embolism during their formation. 18 cases have been seen during E.C.C. and 2 at the stop of E.C.C. In 9 cases, it was an... | [Cerebral arterial embolism during extracorporeal circulation]. From October 1st 1970 to October 1st 1975, electrical and clinical post-operative observation of 1.700 operations under E.C.C. allowed record of E.E.G. and thus study incidents depending of cerebral embolism during their formation. 18 cases have been seen... | [
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PMID:16536 | [Brachial diplegia--a post ECC neurological complication of a specific type]. | Five cases of neurological disorders occurring after extra-corporeal circulation are presented owing to the singular nature of the clinical picture made up by the essential element of a progressive brachial diplegia, free from any sensory disorder. The topography of the lesion--single medullary lesion or bilateral ence... | [Brachial diplegia--a post ECC neurological complication of a specific type]. Five cases of neurological disorders occurring after extra-corporeal circulation are presented owing to the singular nature of the clinical picture made up by the essential element of a progressive brachial diplegia, free from any sensory dis... | [
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PMID:16537 | [Early neurological complications after cardiac surgery under ECC]. | A non-trifling frequency (3,3 p. 100) of neurologic complications is observed after surgery under E.C.C. The part of some factors has been analysed and discussed, especially those played by the type of the system used, quality of the E.C.C., and the patients' conditions. Many problems are still unresolved. The actual g... | [Early neurological complications after cardiac surgery under ECC]. A non-trifling frequency (3,3 p. 100) of neurologic complications is observed after surgery under E.C.C. The part of some factors has been analysed and discussed, especially those played by the type of the system used, quality of the E.C.C., and the pa... | [
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PMID:16538 | [Pulmonary complications after extracorporeal circulation. ECC lung syndrome]. | Pulmonary complications after cardiac surgery under extracorporeal circulation remain frequent and sometimes grave, in spite of the great progress which has been made over the past 20 years in the methods of cardiorespiratory assistance. The authors analyse the clinical and radiological repercussions of perfusion on th... | [Pulmonary complications after extracorporeal circulation. ECC lung syndrome]. Pulmonary complications after cardiac surgery under extracorporeal circulation remain frequent and sometimes grave, in spite of the great progress which has been made over the past 20 years in the methods of cardiorespiratory assistance. The... | [
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PMID:16539 | [Technics of anesthesia and hypothermia for the infant. Choice of replacement fluid for the circuit]. | Sixty-five infants were submitted to complete repairment of a congenital cardiopathy under profound hypothermia and ECC. Description of the preparation of the young surgical patient, of the anesthesia, of the technique of ECC. The overall mortality was 35.5 p. 100. The hypothermia induced by ECC, does not introduce any... | [Technics of anesthesia and hypothermia for the infant. Choice of replacement fluid for the circuit]. Sixty-five infants were submitted to complete repairment of a congenital cardiopathy under profound hypothermia and ECC. Description of the preparation of the young surgical patient, of the anesthesia, of the technique... | [
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PMID:16540 | [Use of a membrane oxygenator in extracorporeal circulation in the child. Preliminary conclusions]. | The comparison of two types of oxygenators, the bubble and membrane oxygenator, in cardiac surgery under ECC, in infants. The results were not subjected to a statistical study. However, it seems that the membrane oxygenator enables one to obtain a satisfactory hematosis in a simpler fashion (the addition of CO2 being a... | [Use of a membrane oxygenator in extracorporeal circulation in the child. Preliminary conclusions]. The comparison of two types of oxygenators, the bubble and membrane oxygenator, in cardiac surgery under ECC, in infants. The results were not subjected to a statistical study. However, it seems that the membrane oxygena... | [
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PMID:16541 | [Fluid mass distribution during extracorporeal circulation]. | The author first recalls close relations existing in physiologic conditions between central venous pressure and blood mass. During E.C.C., this relation is out of truth through the action of venous correlations and of outout. Then studying distribution of blood mass in the different compartments, he notes that during E... | [Fluid mass distribution during extracorporeal circulation]. The author first recalls close relations existing in physiologic conditions between central venous pressure and blood mass. During E.C.C., this relation is out of truth through the action of venous correlations and of outout. Then studying distribution of blo... | [
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PMID:16542 | [Proteins and blood volume after cardiac surgery under ECC and hemodilution]. | The variations in protein, bodyweight and circulating blood volume during operation are studied in 18 patients operated under ECC. The frequency of hypovolemia with hypoproteinemia and over hydration of the interstitial medium is confirmed. The prolongation of ECC beyond 120 minutes is accompanied by a considerable red... | [Proteins and blood volume after cardiac surgery under ECC and hemodilution]. The variations in protein, bodyweight and circulating blood volume during operation are studied in 18 patients operated under ECC. The frequency of hypovolemia with hypoproteinemia and over hydration of the interstitial medium is confirmed. T... | [
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PMID:16543 | [Direct action of extracorporeal circulation on platelets and coagulation factors]. | Concerning a study carried out in 250 patients, the authors confirm the classical notions concerning the fall in platelets, fibrinogenesis, factor II, XII AT3 and plasminogen during ECC. A more precise study of platelet levels shows important variations depending on the patients, whereas the length of time of ECC, the ... | [Direct action of extracorporeal circulation on platelets and coagulation factors]. Concerning a study carried out in 250 patients, the authors confirm the classical notions concerning the fall in platelets, fibrinogenesis, factor II, XII AT3 and plasminogen during ECC. A more precise study of platelet levels shows imp... | [
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PMID:16544 | [Coagulation deficits and hemorrhagic consequences after cardiac surgery under ECC]. | I--A statistical study of the results of tests of hemostasis was carried out in patients who had undergone major cardiac surgery with extra-corporeal circulation. There were two series of patients (1.504 and 547 operated) suffering mainly from congenital cardiopathies, valvulopathies or coronaritis. Bearing in mind the... | [Coagulation deficits and hemorrhagic consequences after cardiac surgery under ECC]. I--A statistical study of the results of tests of hemostasis was carried out in patients who had undergone major cardiac surgery with extra-corporeal circulation. There were two series of patients (1.504 and 547 operated) suffering mai... | [
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PMID:16545 | [Variations in hemostasis in the infant under deep hypothermia]. | Effects on hemostasis of deep hypothermia on infant has been studied on 29 infants operated upon for a cardiopathy under deep hypothermia. Results of this study show a diminution of the coagulation factors rate, an augmentation of the fibrinolytic activity and an unforeseable variability of the residual heparin leading... | [Variations in hemostasis in the infant under deep hypothermia]. Effects on hemostasis of deep hypothermia on infant has been studied on 29 infants operated upon for a cardiopathy under deep hypothermia. Results of this study show a diminution of the coagulation factors rate, an augmentation of the fibrinolytic activit... | [
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PMID:16546 | [Physiopathology of low cardiac outputs after ECC and their treatment]. | Etiologic circumtances of low cardiac outputs are studied according as they concern a diminution of the precharge (hypovolemy of different reasons), an augmentation of the postcharge (by augmentation of aortic impedance or resistance to blood flow) or a cardiac deficiency. The latter can be of non-ischemic origin (effe... | [Physiopathology of low cardiac outputs after ECC and their treatment]. Etiologic circumtances of low cardiac outputs are studied according as they concern a diminution of the precharge (hypovolemy of different reasons), an augmentation of the postcharge (by augmentation of aortic impedance or resistance to blood flow)... | [
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PMID:16547 | [Hemodynamic aspect of post ECC cardiac failures. Study of 193 cases]. | The aim of this study is to define the hemodynamic characteristics of this "clinical model" of acute cardiac failure observed after cardiac surgery carried out under extra-corporeal circulation, which constitutes the essential cause of "post-operative low cardiac output syndrome". The 193 patients in this study make up... | [Hemodynamic aspect of post ECC cardiac failures. Study of 193 cases]. The aim of this study is to define the hemodynamic characteristics of this "clinical model" of acute cardiac failure observed after cardiac surgery carried out under extra-corporeal circulation, which constitutes the essential cause of "post-operati... | [
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PMID:16548 | [Acute renal failure after cardiac surgery under extracorporeal circulation]. | Acute renal failure (ARF) following cardiac surgery under extra-corporeal circulation is a grave but infrequent complication. Numerous physiopathological factors accounting for its origin are analyzed, those related to ECC and those of the immediate post-operative period. The course of these cares of ARF and the elemen... | [Acute renal failure after cardiac surgery under extracorporeal circulation]. Acute renal failure (ARF) following cardiac surgery under extra-corporeal circulation is a grave but infrequent complication. Numerous physiopathological factors accounting for its origin are analyzed, those related to ECC and those of the im... | [
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PMID:16549 | [Kidney failure after ectracorporeal circulation in cardiac surgery]. | The renal function of 113 patients undergoing cardiac surgery under ECC was studied. In 32 p. 100 of the cases renal involvement was noted which was moderate in 18 p. 100 of the cases, severe in 10 p. 100 of the cases and anuric in 4 p. 100 of the cases. Valvular surgery was complicated once in every three cases by ren... | [Kidney failure after ectracorporeal circulation in cardiac surgery]. The renal function of 113 patients undergoing cardiac surgery under ECC was studied. In 32 p. 100 of the cases renal involvement was noted which was moderate in 18 p. 100 of the cases, severe in 10 p. 100 of the cases and anuric in 4 p. 100 of the ca... | [
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PMID:16550 | L(+) lactate dehydrogenase activity from the electric organ of Electrophorus electricus (L.). | Properties of L(+) lactate dehydrogenase (LDH) of Electrophorus electricus (L.) electric organ were studied, comparing the substrates pyruvate and lactate. Electric organ LDH is a soluble enzyme with a pH optimum of 7.4 for pyruvate and 9.0 for lactate. The apparent Km was lower for pyruvate (Km = 2.5 X 10(-4) M) than ... | L(+) lactate dehydrogenase activity from the electric organ of Electrophorus electricus (L.). Properties of L(+) lactate dehydrogenase (LDH) of Electrophorus electricus (L.) electric organ were studied, comparing the substrates pyruvate and lactate. Electric organ LDH is a soluble enzyme with a pH optimum of 7.4 for py... | [
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PMID:16554 | Influence of reagent quality and reaction conditions on the determination of serum albumin by the bromcresol green dye-binding method. | In an age of reference methodologies and sophisticated quality control techniques it is surprising that so little attention is paid to the quality of the reagents that are used. This paper reports on an investigation of the bromcresol green dye-binding procedure for the estimation of serum albumin in which particular a... | Influence of reagent quality and reaction conditions on the determination of serum albumin by the bromcresol green dye-binding method. In an age of reference methodologies and sophisticated quality control techniques it is surprising that so little attention is paid to the quality of the reagents that are used. This pa... | [
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PMID:16558 | [Endocrine polyadenomatosis associated with prolactin pituitary adenoma and an intrathyroidal parathyroid adenoma]. | A pituitary adenoma was removed transsphenoidally from a 20-yr-old woman with secondary amenorrhea, galactorrhea, and hyperprolactinemia. Light and electronic microscopy, immunocytology characterized a prolactin cell tumor. The patient also underwent three surgical explorations for hyperparathyroidism. Only after selec... | [Endocrine polyadenomatosis associated with prolactin pituitary adenoma and an intrathyroidal parathyroid adenoma]. A pituitary adenoma was removed transsphenoidally from a 20-yr-old woman with secondary amenorrhea, galactorrhea, and hyperprolactinemia. Light and electronic microscopy, immunocytology characterized a pr... | [
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PMID:16559 | Renal function during and following obstruction. | The effects of urinary-tract obstruction on renal function have been clarified using modern physiologic techniques in animal models. These effects are obviously dependent on the severity and duration of obstruction, together with the presence or absence of extrarenal factors, particularly uremia, as exemplified by the ... | Renal function during and following obstruction. The effects of urinary-tract obstruction on renal function have been clarified using modern physiologic techniques in animal models. These effects are obviously dependent on the severity and duration of obstruction, together with the presence or absence of extrarenal fac... | [
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PMID:16560 | Effect of anesthetic drugs on myocardial performance in man. | All potent CNS depressant drugs can depress cardiac function in man in a dose-dependent manner. The dose-effect curve is considerably flatter with several drugs (diethyl ether, cyclopropane, fluroxene, isoflurane, and ketamine), presumably from sympathetic nervous-system activation. Potent analgesics and tranquilizers ... | Effect of anesthetic drugs on myocardial performance in man. All potent CNS depressant drugs can depress cardiac function in man in a dose-dependent manner. The dose-effect curve is considerably flatter with several drugs (diethyl ether, cyclopropane, fluroxene, isoflurane, and ketamine), presumably from sympathetic ne... | [
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PMID:16561 | [Synthetic medium for the biosynthesis of gentamicin]. | A synthetic medium for biosynthesis of gentamicin was developed. It includes maltose, gelatine, potassium phosphate, ammonium sulphate, cobalt chloride, sodium chloride, magnesium sulphate and zinc sulphate. The dynamics of the biochemical changes in the above medium was studied. | [Synthetic medium for the biosynthesis of gentamicin]. A synthetic medium for biosynthesis of gentamicin was developed. It includes maltose, gelatine, potassium phosphate, ammonium sulphate, cobalt chloride, sodium chloride, magnesium sulphate and zinc sulphate. The dynamics of the biochemical changes in the above medi... | [
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PMID:16562 | [Penicillin amidase from E. coli. Some physicochemical properties of the soluble enzyme]. | Homogeneity of the enzyme was shown with the methods of gel filtration and disc electrophoresis. The molecular mass of penicillinamidase (PA) was determined. Sorption of PA by a carboxylic ion exchanger within a wide range of pH was studied. The values of pH in the ion exchanger phase under the conditions of the enzyme... | [Penicillin amidase from E. coli. Some physicochemical properties of the soluble enzyme]. Homogeneity of the enzyme was shown with the methods of gel filtration and disc electrophoresis. The molecular mass of penicillinamidase (PA) was determined. Sorption of PA by a carboxylic ion exchanger within a wide range of pH w... | [
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PMID:16563 | [Penicillin amidase from E. coli. Some physicochemical properties of the enzyme incorporated into polyacrylamide gel]. | The physico-chemical properties of penicillinamidase (PA) immobilized in polyacrylamide gel (IPA) were investigated. It was shown that simple incorporation of PA into polyacrylamide gel was not effective because of gradual washing out of the enzyme. The use of a complex method for the immobilization (immobilization in ... | [Penicillin amidase from E. coli. Some physicochemical properties of the enzyme incorporated into polyacrylamide gel]. The physico-chemical properties of penicillinamidase (PA) immobilized in polyacrylamide gel (IPA) were investigated. It was shown that simple incorporation of PA into polyacrylamide gel was not effecti... | [
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PMID:16564 | Penicillin resistance and penicillinase production in clinical isolates of Bacteroides melaninogenicus. | The minimum inhibitory concentrations (MIC) of penicillin and six other antimicrobials were determined for 50 clinical isolates of Bacteroides melaninogenicus. Agar dilution susceptibilities were performed using supplemented brucella blood agar and the proposed National Committee for Clinical Laboratory Standards stand... | Penicillin resistance and penicillinase production in clinical isolates of Bacteroides melaninogenicus. The minimum inhibitory concentrations (MIC) of penicillin and six other antimicrobials were determined for 50 clinical isolates of Bacteroides melaninogenicus. Agar dilution susceptibilities were performed using supp... | [
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PMID:16571 | Clinical and histological study of coal tar phototoxicity in humans. | Coal tars of different origin were compared with regard to their capacity to cause a phototoxic reaction in human skin. The photosensitizing potencies were found to differ. Tars that were partially refined had less activity than crude coal tar. An extract of tar, liquor carbonis detergens, was the least photosensitizin... | Clinical and histological study of coal tar phototoxicity in humans. Coal tars of different origin were compared with regard to their capacity to cause a phototoxic reaction in human skin. The photosensitizing potencies were found to differ. Tars that were partially refined had less activity than crude coal tar. An ext... | [
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PMID:16574 | Comparison of the effects of alclofenac, flurbiprofen, and prednisolone on acute inflammatory response in the rat. | The fluid and cellular phases of the inflammatory response were measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Fluribiprofen and prednisolone were equipotent and were capable of almost completely suppressing fluid and ce... | Comparison of the effects of alclofenac, flurbiprofen, and prednisolone on acute inflammatory response in the rat. The fluid and cellular phases of the inflammatory response were measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tubercul... | [
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PMID:16576 | Alpha-Isopropylmalate synthase from Alcaligenes eutrophus H 16 I. Purification and general properties. | alpha-Isopropylmalate (IPM) synthase, the first enzyme in the biosynthesis of L-leucine, was purified to a specific activity of 12 micronmole/min x mg protein from the valine-isoleucine double auxotrophic mutant A-81 of the hydrogen bacterium Alcaligenes eutrophus H16. The activity in crude extracts of derepressed cell... | Alpha-Isopropylmalate synthase from Alcaligenes eutrophus H 16 I. Purification and general properties. alpha-Isopropylmalate (IPM) synthase, the first enzyme in the biosynthesis of L-leucine, was purified to a specific activity of 12 micronmole/min x mg protein from the valine-isoleucine double auxotrophic mutant A-81 ... | [
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PMID:16577 | Adenosine-5'-phosphosulfate (APS) as sulfate donor for assimilatory sulfate reduction in Rhodospirillum rubrum. | Crude extracts of Rhodospirillum rubrum catalyzed the formation of acid-volatile radioactivity from (35S) sulfate, (35S) adenosine-5'-phosphosulfate, and (35S) 3'-phosphoadenosine-5'-phosphosulfate. An enzyme fraction similar to APS-sulfotransferases from plant sources was purified 228-fold from Rhodospirillum rubrum. ... | Adenosine-5'-phosphosulfate (APS) as sulfate donor for assimilatory sulfate reduction in Rhodospirillum rubrum. Crude extracts of Rhodospirillum rubrum catalyzed the formation of acid-volatile radioactivity from (35S) sulfate, (35S) adenosine-5'-phosphosulfate, and (35S) 3'-phosphoadenosine-5'-phosphosulfate. An enzyme... | [
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PMID:16578 | Allohydroxy-D-proline dehydrogenase. An inducible membrane-bound enzyme in Pseudomonas aeruginosa PA01. | Growth of Pseudomonas aeruginosa PA01 on isomers of hydroxyproline induced the synthesis of an allohydroxy-D-proline dehydrogenase. The enzyme resembled the D-alanine dehydrogenase of this organism in its association with the particulate fraction and its linkage to oxygen through a cytochrome-containing respiratory cha... | Allohydroxy-D-proline dehydrogenase. An inducible membrane-bound enzyme in Pseudomonas aeruginosa PA01. Growth of Pseudomonas aeruginosa PA01 on isomers of hydroxyproline induced the synthesis of an allohydroxy-D-proline dehydrogenase. The enzyme resembled the D-alanine dehydrogenase of this organism in its association... | [
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PMID:16580 | Neurophysiologic and pathologic aspects of acute and chronic pain. | Acute pain produced by disease or injury is the net effect of highly complex interactions of various neural systems and psychological factors. Through the interaction of the afferent systems and neocortical processes, the individual is provided perceptual information regarding location, magnitude, and spatial and tempo... | Neurophysiologic and pathologic aspects of acute and chronic pain. Acute pain produced by disease or injury is the net effect of highly complex interactions of various neural systems and psychological factors. Through the interaction of the afferent systems and neocortical processes, the individual is provided perceptu... | [
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PMID:16581 | [Ultrastructure of the parietal cells of the gastric mucosa in ulcer disease of the duodenum with a hyperacid syndrome (ultrastructurometric study)]. | An electron-microscopy investigation and morphometric analysis were carried out in 30 specimens of bioptic material of the fundal part of the stomach in patients with duodenal ulcer with the hyperacid syndrome. At all levels of the Major gastric glands parietal cells with morphological signs of intensive secretory acti... | [Ultrastructure of the parietal cells of the gastric mucosa in ulcer disease of the duodenum with a hyperacid syndrome (ultrastructurometric study)]. An electron-microscopy investigation and morphometric analysis were carried out in 30 specimens of bioptic material of the fundal part of the stomach in patients with duo... | [
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PMID:16582 | Parkinson's disease. | The classical clinical picture of Parkinson's disease is all too frequently encountered in the elderly patient. The modern classification of causes of Parkinson's disease lists 'idiopathic', and 'post-encephalitic forms', the latter being uncommon in this community. | Parkinson's disease. The classical clinical picture of Parkinson's disease is all too frequently encountered in the elderly patient. The modern classification of causes of Parkinson's disease lists 'idiopathic', and 'post-encephalitic forms', the latter being uncommon in this community. | [
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PMID:16579 | [Carbohydrate-dependent lipidogenesis. Review of the literature and experimental study]. | The literature on glycide-induced lipidogenesis is reviewed. This is an important question also because of its relation to the pathogenesis of pathological conditions such as ketoacidosis, obesity and hypertriglyceridaemia. Doubt is expressed concerning the interpretation of some experimental procedures used in determi... | [Carbohydrate-dependent lipidogenesis. Review of the literature and experimental study]. The literature on glycide-induced lipidogenesis is reviewed. This is an important question also because of its relation to the pathogenesis of pathological conditions such as ketoacidosis, obesity and hypertriglyceridaemia. Doubt i... | [
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PMID:16583 | Survival test of submersible life support systems. | An experiment to validate predictions concerning submersible survivability was performed in December, 1975, by members of the Canadian Forces in the CF Submersible Lockout Vehicle SDL-1 in Halifax Harbour in water of 4 degrees C temperature at a depth of 40 ft. Data was collected relevant to the life support equipment ... | Survival test of submersible life support systems. An experiment to validate predictions concerning submersible survivability was performed in December, 1975, by members of the Canadian Forces in the CF Submersible Lockout Vehicle SDL-1 in Halifax Harbour in water of 4 degrees C temperature at a depth of 40 ft. Data wa... | [
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PMID:16584 | Systematic desensitization of a phobia for flying with the use of suggestion. | This case study describes the successful treatment of a phobia for flying in an active-duty United States Marine helicopter crew chief by using systematic desensitization. Systematic desensitization is briefly described as a treatment technique which incorporates relaxation exercises paired with the visualization of an... | Systematic desensitization of a phobia for flying with the use of suggestion. This case study describes the successful treatment of a phobia for flying in an active-duty United States Marine helicopter crew chief by using systematic desensitization. Systematic desensitization is briefly described as a treatment techniq... | [
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PMID:16587 | The intracellular pH and the buffer capacity of the heart. | The intracellular buffering (delta HCO3-/delta pH) in rats is lowest in skeletal muscle, intermediate in the diaphragm and highest in cardiac muscle. In the hypertrophic heart due to aortic constriction or to the Goldblatt mechanism the buffer value increases markedly during the first weeks, but returns to normal or ev... | The intracellular pH and the buffer capacity of the heart. The intracellular buffering (delta HCO3-/delta pH) in rats is lowest in skeletal muscle, intermediate in the diaphragm and highest in cardiac muscle. In the hypertrophic heart due to aortic constriction or to the Goldblatt mechanism the buffer value increases m... | [
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PMID:16618 | Lymphocytotoxic antibodies. HLA antigen associations, disease associations, and family studies. | Lymphocytotoxic antibodies (LCTAB) were sought in sera of patients with rheumatic diseases and in family members. Patients with SLE and cutaneous necrotizing venulitis and family members of JRA patients had an increased frequency of LCTAB; JRA patients and family members of SLE patients did not. The only association be... | Lymphocytotoxic antibodies. HLA antigen associations, disease associations, and family studies. Lymphocytotoxic antibodies (LCTAB) were sought in sera of patients with rheumatic diseases and in family members. Patients with SLE and cutaneous necrotizing venulitis and family members of JRA patients had an increased freq... | [
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PMID:16619 | Determination of flunitrazepam, desmethylflunitrazepam and clonazepam in plasma by gas liquid chromatography with an internal standard. | A method is developed for gas-chromatographic determination of flunitrazepam, desmethylflunitrazepam and clonazepam in plasma, using methylclonazepam as internal standard. Following extraction of the benzodiazepines and their hydrolysis, the benzophenones are analyzed by gas-chromatography, with a glass column filled w... | Determination of flunitrazepam, desmethylflunitrazepam and clonazepam in plasma by gas liquid chromatography with an internal standard. A method is developed for gas-chromatographic determination of flunitrazepam, desmethylflunitrazepam and clonazepam in plasma, using methylclonazepam as internal standard. Following ex... | [
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PMID:16620 | [Studies on the reactability of chlordiazepoxide to its N-nitrosos derivative in physiological conditions (author's transl)]. | It is shown that chlordiazepoxide readily reacts with sodium nitrite in an aqueous HCl solution as well as in human gastric juice to N-nitrosochlordiazepoxide with a high yield (up to 75%). For this reaction the pH optimum has been determined to be 1.4. After oral application of chlordiazepoxide alone or in combination... | [Studies on the reactability of chlordiazepoxide to its N-nitrosos derivative in physiological conditions (author's transl)]. It is shown that chlordiazepoxide readily reacts with sodium nitrite in an aqueous HCl solution as well as in human gastric juice to N-nitrosochlordiazepoxide with a high yield (up to 75%). For ... | [
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PMID:16621 | Serum gonadotropins in the rat after prenatal damage to the testes by busulfan and their reaction to cryptorchidism, castration and administration of testosterone. | Adult male rats prenatally treated with 1,4-bis-(methanesulfonyloxy)-butane (busulfan), which damages the gonocytes, undergo cryptorchidization, castration or testosterone treatment and the FSH, LH and testosterone levels in serum are measured. Basal values of these hormones do not differ from those of controls. After ... | Serum gonadotropins in the rat after prenatal damage to the testes by busulfan and their reaction to cryptorchidism, castration and administration of testosterone. Adult male rats prenatally treated with 1,4-bis-(methanesulfonyloxy)-butane (busulfan), which damages the gonocytes, undergo cryptorchidization, castration ... | [
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PMID:16622 | Double-blind cross-over clinical comparison of two 2'-chloro benzodiazepines: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam) versus 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in neurotic anxiety. | A group of 20 female neurotic inpatients has been treated with 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one-(chlordesmethyldiazepan)- 7-chloro-5(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) according to a double-blind cross-over design. For each drug clinical evalua... | Double-blind cross-over clinical comparison of two 2'-chloro benzodiazepines: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam) versus 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in neurotic anxiety. A group of 20 female neurotic inp... | [
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PMID:16623 | [Psychic drugs: predicting therapeutic effects and doses by test models with normal subjects (author's transl)]. | Pharmacopsychology is concerned with the effects of drugs on "psychic" processes. It is attempted to demonstrate approaches which meet the criteria of scientific methodology. These approaches are based upon observation of somatic and/or behavioral changes. The steps from "naive" observation to the generation of objecti... | [Psychic drugs: predicting therapeutic effects and doses by test models with normal subjects (author's transl)]. Pharmacopsychology is concerned with the effects of drugs on "psychic" processes. It is attempted to demonstrate approaches which meet the criteria of scientific methodology. These approaches are based upon ... | [
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PMID:16624 | Destruction of endogenous low density lipoprotein in incubated intima. | The effect of incubation on the content of endogenous intact plasma lipoprotein (LP) has been examined in minced samples of normal intima and lesions from 38 patients. Both the electrophoretically mobile and the immobilized LP fractions decreased on incubation, and the rate of destruction was proportional to LP concent... | Destruction of endogenous low density lipoprotein in incubated intima. The effect of incubation on the content of endogenous intact plasma lipoprotein (LP) has been examined in minced samples of normal intima and lesions from 38 patients. Both the electrophoretically mobile and the immobilized LP fractions decreased on... | [
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PMID:16625 | Effect of prostaglandins E1 and F1alpha on the activities of cholesteryl ester synthetase and cholesteryl ester hydrolases of pigeon aorta in vitro. | The in vitro effects of prostaglandins E1 and F1alpha on the activity of cholesteryl ester synthetase and cholesteryl ester hydrolase activities of the pigeon aorta were examined. It was found that prostaglandin E1 markedly inhibited the cholesteryl ester hydrolase activity in the supernatant fraction and slightly inh... | Effect of prostaglandins E1 and F1alpha on the activities of cholesteryl ester synthetase and cholesteryl ester hydrolases of pigeon aorta in vitro. The in vitro effects of prostaglandins E1 and F1alpha on the activity of cholesteryl ester synthetase and cholesteryl ester hydrolase activities of the pigeon aorta were e... | [
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PMID:16632 | Comparative beta-adrenoceptor blocking effects and pharmacokinetics of penbutolol and propranolol in man. | 1 The beta-adrenoceptor blocking effects of penbutolol were compared with those of propranolol and a placebo in a double-blind trial involving six healthy volunteers. 2 Heart rate (HR), systolic blood pressure (SBP) and peak expiratory flow rate (PEFR) were measured at rest and during vigorous exercise before and at in... | Comparative beta-adrenoceptor blocking effects and pharmacokinetics of penbutolol and propranolol in man. 1 The beta-adrenoceptor blocking effects of penbutolol were compared with those of propranolol and a placebo in a double-blind trial involving six healthy volunteers. 2 Heart rate (HR), systolic blood pressure (SBP... | [
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PMID:16633 | Measurement of thioridazine in blood and urine. | 1 Thioridazine can be specifically, simply, and reliably measured in plasma and urine by gas chromatography using hexane extraction and prochlorperazine as internal standard; fluorimetry is non-specific. 2 The method can also measure thioridazine ring sulphoxide, and mesoridazine-plus-sulphoridazine (M/S). 3 After sing... | Measurement of thioridazine in blood and urine. 1 Thioridazine can be specifically, simply, and reliably measured in plasma and urine by gas chromatography using hexane extraction and prochlorperazine as internal standard; fluorimetry is non-specific. 2 The method can also measure thioridazine ring sulphoxide, and meso... | [
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PMID:16634 | The metabolism, distribution and elimination of chlorphentermine in man. | 1 A gas-liquid chromatography procedure for the determination of chlorphentermine (I), N-hydroxychlorphentermine (II) and alpha,alpha-dimethyl-alpha-nitro-beta-(4-chlorophenyl)ethane (IV) in urine has been developed. Also methods are reported to determine conjugated II and the total N-oxidized metabolites of I, i.e. II... | The metabolism, distribution and elimination of chlorphentermine in man. 1 A gas-liquid chromatography procedure for the determination of chlorphentermine (I), N-hydroxychlorphentermine (II) and alpha,alpha-dimethyl-alpha-nitro-beta-(4-chlorophenyl)ethane (IV) in urine has been developed. Also methods are reported to d... | [
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PMID:16635 | A repeated dose comparison of dichloralphenazone, flunitrazepam and amylobarbitone sodium on some aspects of sleep and early morning behaviour in normal subjects. | 1 Seven normal subjects were given three different hypnotics (flunitrazepam 1 mg, amylobarbitone sodium 100 mg and dichloralphenazone 1300 mg) for four consecutive nights each. 2 All three substances improved subjective assessment of the ease of getting to sleep. Flunitrazepam was rated as better than eithr dichloralph... | A repeated dose comparison of dichloralphenazone, flunitrazepam and amylobarbitone sodium on some aspects of sleep and early morning behaviour in normal subjects. 1 Seven normal subjects were given three different hypnotics (flunitrazepam 1 mg, amylobarbitone sodium 100 mg and dichloralphenazone 1300 mg) for four conse... | [
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PMID:16637 | Localized scleroderma-like lesions after bone marrow transplantation in man. A chronic graft versus host reaction. | Localized scleroderma-like skin lesions which developed in two children, from 8 to 10 months after successful bone marrow transplantation for aplastic anaemia, showed histopathological features resembling those of scleroderma. This finding, like the animal models described in the literature, provides additional support... | Localized scleroderma-like lesions after bone marrow transplantation in man. A chronic graft versus host reaction. Localized scleroderma-like skin lesions which developed in two children, from 8 to 10 months after successful bone marrow transplantation for aplastic anaemia, showed histopathological features resembling ... | [
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PMID:16638 | Proton nuclear magnetic resonance study of the effect of pH on tRNA structure. | The low-field 220-MHz proton nuclear magnetic resonance (NMR) spectra of four tRNA molecules, Escherichia coli tRNAPhe, tRNA1Val, and tRNAfMet1, and yeast tRNAPhe, at neutral and mildly acidic pH are compared. We find a net increase in the number of resonances contributing to the -9.9-ppm peak (downfield from sodium 4,... | Proton nuclear magnetic resonance study of the effect of pH on tRNA structure. The low-field 220-MHz proton nuclear magnetic resonance (NMR) spectra of four tRNA molecules, Escherichia coli tRNAPhe, tRNA1Val, and tRNAfMet1, and yeast tRNAPhe, at neutral and mildly acidic pH are compared. We find a net increase in the n... | [
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PMID:16639 | Sodium-dependent methyl 1-thio-beta-D-galactopyranoside transport in membrane vesicles isolated from Salmonella typhimurium. | Membrane vesicles isolated from Salmonella typhimurium G-30 grown in the presence of melibiose catalyze methyl 1-thio-beta-D-galactopyranoside (TMG) transport in the presence of sodium or lithium, as shown initially with intact cells by Stock and Roseman (Stock, J., and Roseman, S. (1971), Biochem. Biophys. Res. Commun... | Sodium-dependent methyl 1-thio-beta-D-galactopyranoside transport in membrane vesicles isolated from Salmonella typhimurium. Membrane vesicles isolated from Salmonella typhimurium G-30 grown in the presence of melibiose catalyze methyl 1-thio-beta-D-galactopyranoside (TMG) transport in the presence of sodium or lithium... | [
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PMID:16640 | Determination of the rate-limiting steps and chemical mechanism of fructokinase by isotope exchange, isotope partitioning, and pH studies. | Isotope exchange studies show that beef liver fructokinase has a random kinetic mechanism in which release of fructose from the enzyme is slower than that catalytic reaction. The stickiness of fructose in the presence of MgATP is confirmed by isotope partition studies, which show it to be released 0.53 times as fast as... | Determination of the rate-limiting steps and chemical mechanism of fructokinase by isotope exchange, isotope partitioning, and pH studies. Isotope exchange studies show that beef liver fructokinase has a random kinetic mechanism in which release of fructose from the enzyme is slower than that catalytic reaction. The st... | [
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PMID:16641 | Carbon-13 nuclear magnetic resonance probe of active-site ionizations in human carbonic anhydrase B. | Human carbonic anhydrase B (HCAB), prepared by a new affinity chromatography procedure, was carboxymethylated exclusively at NT of its active-site histidine-200 using 90% [1-13C]bromoacetate. The 13C nuclear magnetic resonance signal of the covalently attached carboxylate was easily detected over the natural abundance ... | Carbon-13 nuclear magnetic resonance probe of active-site ionizations in human carbonic anhydrase B. Human carbonic anhydrase B (HCAB), prepared by a new affinity chromatography procedure, was carboxymethylated exclusively at NT of its active-site histidine-200 using 90% [1-13C]bromoacetate. The 13C nuclear magnetic re... | [
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PMID:16642 | Comparison of solubility properties of alpha-paramyosin, beta-paramyosin and acid-extracted paramyosin. | The solubility properties of paramyosin in the zones of pH and ionic strength in which aggregation occurs were initially studied using preparations isolated by a method originally described by Bailey (Bailey, K. (1956), Pubbl. Stn. Zool. Napoli 29, 26). Other preparations yielding apparently different protein component... | Comparison of solubility properties of alpha-paramyosin, beta-paramyosin and acid-extracted paramyosin. The solubility properties of paramyosin in the zones of pH and ionic strength in which aggregation occurs were initially studied using preparations isolated by a method originally described by Bailey (Bailey, K. (195... | [
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PMID:16650 | Cotransport of phosphate and sodium by yeast. | Phosphate uptake by yeast at pH 7.2 is mediated by two mechanisms, one of which has a Km of 30 micronM and is independent of sodium, and a sodium-dependent mechanism with a Km of 0.6 micronM, both Km values with respect to monovalent phosphate. The sodium-dependent mechanism has two sites with affinity for Na+, with af... | Cotransport of phosphate and sodium by yeast. Phosphate uptake by yeast at pH 7.2 is mediated by two mechanisms, one of which has a Km of 30 micronM and is independent of sodium, and a sodium-dependent mechanism with a Km of 0.6 micronM, both Km values with respect to monovalent phosphate. The sodium-dependent mechanis... | [
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PMID:16651 | Intracellular distribution of ribonuclease activity during erythroid cell development. | Five ribonuclease activities, separable by polyacrylamide gel electrophoresis, have been detected in erythroid bone marrow cells from anaemic rabbits. Their intracellular distribution has been investigated and compared with that of the ribonucleases in reticulocytes. Both the acid and alkaline ribonuclease activities o... | Intracellular distribution of ribonuclease activity during erythroid cell development. Five ribonuclease activities, separable by polyacrylamide gel electrophoresis, have been detected in erythroid bone marrow cells from anaemic rabbits. Their intracellular distribution has been investigated and compared with that of t... | [
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PMID:16652 | The essential activated carboxyl group of inorganic pyrophosphatase. | 1. A carboxyl group of high reactivity has been found in inorganic pyrophosphatase (pyrophosphate phosphohydrolase, EC 3.6.1.1) from yeast. This group interacts with agents which react neither with carboxyl groups of low molecular weight compounds nor with other carboxyl groups of the protein. 2. The reaction of this a... | The essential activated carboxyl group of inorganic pyrophosphatase. 1. A carboxyl group of high reactivity has been found in inorganic pyrophosphatase (pyrophosphate phosphohydrolase, EC 3.6.1.1) from yeast. This group interacts with agents which react neither with carboxyl groups of low molecular weight compounds nor... | [
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PMID:16653 | The stereospecificity of nitrate reductase for hydrogen removal from reduced pyridine nucleotides. | The stereospecificity of the hydrogen removal from reduced pyridine nucleotides catalyzed by nitrate reductase (NADH : nitrate oxidoreductase, EC 1.6.6.1, and NAD(P)H : nitrate oxidoreductase, EC 1.6.6.2) was investigated. A high degree of enzyme purification was required to obtain conclusive results. Improvements are ... | The stereospecificity of nitrate reductase for hydrogen removal from reduced pyridine nucleotides. The stereospecificity of the hydrogen removal from reduced pyridine nucleotides catalyzed by nitrate reductase (NADH : nitrate oxidoreductase, EC 1.6.6.1, and NAD(P)H : nitrate oxidoreductase, EC 1.6.6.2) was investigated... | [
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