id stringlengths 24 24 | type stringclasses 4
values | body stringlengths 13 215 | ideal_answer listlengths 1 12 | exact_answer listlengths 0 44 | snippets listlengths 0 121 | documents listlengths 1 157 | triples listlengths 0 537 | concepts listlengths 0 99 |
|---|---|---|---|---|---|---|---|---|
553bd2f0f321868558000008 | yesno | Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | [
"Yes. Gfi-1B is a transcriptional repressor essential for the regulation of erythropoiesis and megakaryopoiesis. Gfi-1b(-/-) embryonic stem cells fail to contribute to red cells of adult chimeras. Gfi-1b(-/-) embryos exhibit delayed maturation of primitive erythrocytes and subsequently die with failure to produce ... | [
"yes"
] | [
"Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development and lineage specification",
"gfi1aa and gfi1b have distinct roles in regulating primit... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23308270",
"http://www.ncbi.nlm.nih.gov/pubmed/22699452",
"http://www.ncbi.nlm.nih.gov/pubmed/14530176",
"http://www.ncbi.nlm.nih.gov/pubmed/19773260",
"http://www.ncbi.nlm.nih.gov/pubmed/19958752",
"http://www.ncbi.nlm.nih.gov/pubmed/12351384",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030097",
"http://www.uniprot.org/uniprot/GFI1B_MOUSE",
"http://www.uniprot.org/uniprot/GFI1B_HUMAN"
] |
56ed0ba22ac5ed1459000007 | yesno | Has Revlimid been approved by the US Food and Drug Administration? | [
"Yes, Revlimid has been approved by the US Food and Drug Administration for treatment of multiple myeloma."
] | [
"yes"
] | [
"In the past decade, immunomodulatory drugs have been approved by the US Food and Drug Administration for the treatment of multiple myeloma (MM)-and a number of emerging agents that target the cellular pathways or proteins involved in the pathophysiology of MM are currently in development. Lenalidomide (Revlimid) a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25188481",
"http://www.ncbi.nlm.nih.gov/pubmed/17996589",
"http://www.ncbi.nlm.nih.gov/pubmed/25188483",
"http://www.ncbi.nlm.nih.gov/pubmed/23545923",
"http://www.ncbi.nlm.nih.gov/pubmed/17076650",
"http://www.ncbi.nlm.nih.gov/pubmed/17076653",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014486"
] |
51724fca8ed59a060a000013 | factoid | Which is the execution time (complexity) of the Smith-Waterman algorithm for the alignment of two sequences | [
"The complexity of the Smith-Waterman dynamic programming algorithm is quadratic, that is, it runs in time proportional to the product of lengths of the sequences being aligned."
] | [
"quadratic"
] | [
"The problem of finding an optimal structural alignment for a pair of superimposed proteins is often amenable to the Smith-Waterman dynamic programming algorithm, which runs in time proportional to the product of lengths of the sequences being aligned.",
"While this result is not an asymptotic improvement over th... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16522182",
"http://www.ncbi.nlm.nih.gov/pubmed/14668231",
"http://www.ncbi.nlm.nih.gov/pubmed/12804086",
"http://www.ncbi.nlm.nih.gov/pubmed/11301301",
"http://www.ncbi.nlm.nih.gov/pubmed/9021270",
"http://www.ncbi.nlm.nih.gov/pubmed/1774068",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016415",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017385",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017386",
"http://www.nlm.nih.gov/cgi/mesh/2... |
56bcc455d36b5da378000003 | list | List mutations that are implicated in the Gray Platelet Syndrome. | [
"GFI1B and NBEAL2 mutations are implicated in the Gray Platelet Syndrome."
] | [
"GFI1B",
"NBEAL2"
] | [
"A dominant-negative GFI1B mutation in the gray platelet syndrome",
"We detected a nonsense mutation in the gene encoding the transcription factor GFI1B (growth factor independent 1B) that causes autosomal dominant gray platelet syndrome.",
"The genetic defect responsible for gray platelet syndrome was recently... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23861251",
"http://www.ncbi.nlm.nih.gov/pubmed/25258341",
"http://www.ncbi.nlm.nih.gov/pubmed/24325358",
"http://www.ncbi.nlm.nih.gov/pubmed/21765413",
"http://www.ncbi.nlm.nih.gov/pubmed/21765412",
"http://www.ncbi.nlm.nih.gov/pubmed/23100277"
] | [] | [] |
56f1547c2ac5ed1459000010 | yesno | Has single guide RNA been used on human cells? | [
"Yes, sgRNA has been used in human cell lines."
] | [
"yes"
] | [
"We used a library containing 73,000 sgRNAs to generate knockout collections and performed screens in two human cell lines.",
"Here we engineer this system to enable RNA-guided genome regulation in human cells by tethering transcriptional activation domains either directly to a nuclease-null Cas9 protein or to an... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24336569",
"http://www.ncbi.nlm.nih.gov/pubmed/23873081",
"http://www.ncbi.nlm.nih.gov/pubmed/25122746",
"http://www.ncbi.nlm.nih.gov/pubmed/24870050",
"http://www.ncbi.nlm.nih.gov/pubmed/25048165",
"http://www.ncbi.nlm.nih.gov/pubmed/25759096",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017394"
] |
570a5c27cf1c325851000023 | yesno | Is Fibroblast Growth Factor 23 a phosphaturic hormone? | [
"Yes, fbroblast growth factor 23 (FGF23) is a phosphaturic hormone."
] | [
"yes"
] | [
"PTH can induce skeletal synthesis of another potent phosphaturic hormone, fibroblast growth factor 23 (FGF23), ",
" Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that has recently been identified as a CKD-related factor affecting CRS. ",
" circulating phosphaturic hormone fibroblast growth fact... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24991914",
"http://www.ncbi.nlm.nih.gov/pubmed/25007710",
"http://www.ncbi.nlm.nih.gov/pubmed/25380933",
"http://www.ncbi.nlm.nih.gov/pubmed/26131357",
"http://www.ncbi.nlm.nih.gov/pubmed/24466013",
"http://www.ncbi.nlm.nih.gov/pubmed/24980542",
"http://www.ncbi.nlm.n... | [] | [] |
5525317687ecba3764000007 | summary | Which type of cell death is known as anoikis? | [
"Anoikis (Greek for Homelessness) is a programmed cell death induced upon cell detachment from extracellular matrix, behaving as a critical mechanism in preventing adherent-independent cell growth and attachment to an inappropriate matrix, thus avoiding colonizing of distant organs. Anoikis is important in the norm... | [] | [
"As a barrier to metastasis of cancer, cells that lost contact with the neighbouring cells or extracellular matrix(Extracellular matrix, ECM) will be subjected to apoptosis. This cell death process has been termed \"anoikis\".",
"When normal epithelial cells or solid tumor cells without metastatic potential detac... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23830918",
"http://www.ncbi.nlm.nih.gov/pubmed/18579285",
"http://www.ncbi.nlm.nih.gov/pubmed/20577896",
"http://www.ncbi.nlm.nih.gov/pubmed/23357260",
"http://www.ncbi.nlm.nih.gov/pubmed/21114588",
"http://www.ncbi.nlm.nih.gov/pubmed/15302871",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000209",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043276",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010941",
"htt... |
5506c3e38e1671127b00000a | factoid | The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger? | [
"The effects of SEA0400, a selective inhibitor of the Na(+)/Ca(2+) exchanger (NCX), on Na(+)-dependent Ca(2+) uptake and catecholamine (CA) release were examined in bovine adrenal chromaffin cells that were loaded with Na(+) by treatment with ouabain and veratridine. SEA0400 inhibited Na(+)-dependent (45)Ca(2+) upt... | [
"Na(+)/Ca(2+) exchanger",
"NCX"
] | [
"The plasma membrane Na(+)/Ca(2+) exchanger (NCX) is a bidirectional ion transporter that couples the translocation of Na(+) in one direction with that of Ca(2+) in the opposite direction. This system contributes to the regulation of intracellular Ca(2+) concentration via the forward mode (Ca(2+) efflux) or the rev... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19593760",
"http://www.ncbi.nlm.nih.gov/pubmed/22075452",
"http://www.ncbi.nlm.nih.gov/pubmed/23441899",
"http://www.ncbi.nlm.nih.gov/pubmed/15678087",
"http://www.ncbi.nlm.nih.gov/pubmed/22119380",
"http://www.ncbi.nlm.nih.gov/pubmed/21672583",
"http://www.ncbi.nlm.n... | [] | [] |
54fc4e2e6ea36a810c000003 | summary | What is Piebaldism? | [
"Piebaldism is a rare autosomal dominant disorder of melanocyte development characterized by a congenital white forelock and multiple symmetrical stable hypopigmented or depigmented macules."
] | [] | [
"Human piebaldism is a rare autosomal dominant condition characterized by congenital white forelock and depigmented patches of s",
"Piebaldism is a rare genodermatosis caused by KIT mutations. ",
"Piebaldism is a rare autosomal dominant disorder of melanocyte development characterized by a congenital white fore... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11174389",
"http://www.ncbi.nlm.nih.gov/pubmed/21382296",
"http://www.ncbi.nlm.nih.gov/pubmed/20676476",
"http://www.ncbi.nlm.nih.gov/pubmed/22670867",
"http://www.ncbi.nlm.nih.gov/pubmed/23130293",
"http://www.ncbi.nlm.nih.gov/pubmed/23016555",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016116"
] |
56d85e7751531f7e33000001 | factoid | Which SLC family is FLVCR1 a member of? | [
"Feline leukemia virus subgroup C receptor (FLVCR1) is a member of the SLC49 family."
] | [
"SLC49"
] | [
"Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis.",
"Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23506900"
] | [] | [] |
56bb69d0ac7ad1001900000c | yesno | Is amoxicillin used for treatment of malnutrition in children? | [
"Yes, amoxicillin is used for treatment of malnutrition in children."
] | [
"yes"
] | [
" Another RCT did not show superiority of ceftriaxone over amoxicilllin for these same outcomes, but adressed SAM children with and without complications (p = 0.27). Another RCT showed no difference between amoxicillin and cotrimoxazole efficacies for pneumonia in underweight, but not SAM. Our meta-analysis of 12 p... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23326395",
"http://www.ncbi.nlm.nih.gov/pubmed/20545919",
"http://www.ncbi.nlm.nih.gov/pubmed/21836758",
"http://www.ncbi.nlm.nih.gov/pubmed/23755286",
"http://www.ncbi.nlm.nih.gov/pubmed/23363496",
"http://www.ncbi.nlm.nih.gov/pubmed/18318945"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002648",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D044342",
"http://www.biosemantics.org/jochem#4248866",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&ter... |
56e47e0051531f7e3300001c | factoid | Where are the orexigenic peptides synthesized? | [
"The orexigenic peptides are sythesized in the hypothalamus."
] | [
"The orexigenic peptides are sythesized in the hypothalamus."
] | [
"Orexin A and B, orexigenic peptides produced primarily by the lateral hypothalamus t",
"Telmisartin reduced hypothalamic mRNA levels of the orexigenic peptides melanin-concentrating hormone and prepro-orexin",
"expression of the orexigenic peptides, enkephalin (ENK) and galanin (GAL), in developing embryonic h... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22771813",
"http://www.ncbi.nlm.nih.gov/pubmed/25258168",
"http://www.ncbi.nlm.nih.gov/pubmed/23707377",
"http://www.ncbi.nlm.nih.gov/pubmed/25047666",
"http://www.ncbi.nlm.nih.gov/pubmed/24991043",
"http://www.ncbi.nlm.nih.gov/pubmed/22325091",
"http://www.ncbi.nlm.n... | [] | [] |
54dfcdf81388e8454a00000a | summary | What is the mechanism of action of APOBEC3G cytidine deaminase to inhibit HIV-1 replication? | [
"During reverse transcription, APOBEC3G deaminates dC to dU in nascent minus-strand viral DNA, resulting in G-to-A hypermutation in the plus strand DNA to inhibit replication of HIV-1, due to viral cDNA degradation, production of non-functional proteins, formation of undesired stop codons and decreased viral protei... | [] | [
"APOBEC3G inhibits HIV-1 RNA elongation by inactivating the viral trans-activation response element",
"Deamination of cytidine residues in viral DNA is a major mechanism by which APOBEC3G (A3G) inhibits vif-deficient human immunodeficiency virus type 1 (HIV-1) replication. dC-to-dU transition following RNase-H ac... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23152537",
"http://www.ncbi.nlm.nih.gov/pubmed/22787460",
"http://www.ncbi.nlm.nih.gov/pubmed/24651717",
"http://www.ncbi.nlm.nih.gov/pubmed/17126871",
"http://www.ncbi.nlm.nih.gov/pubmed/24623435",
"http://www.ncbi.nlm.nih.gov/pubmed/24345943",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/ABC3G_PANTR",
"http://www.uniprot.org/uniprot/ABC3G_SAGLB",
"http://www.uniprot.org/uniprot/ABC3G_MACFA",
"http://www.uniprot.org/uniprot/ABC3G_LAGLA",
"http://www.uniprot.org/uniprot/ABC3G_PAPAN",
"http://www.uniprot.org/uniprot/ABC3G_GORGO",
"http://www.uniprot.org/unip... |
5721f4b30fd6f91b68000011 | factoid | Which inherited disorder is known to be caused by mutations in the NEMO gene? | [
"Incontinentia pigmenti (IP) is a rare neurocutaneous disorder with a frequency of 1 in 50,000 newborn, and is associated with mutations in IKBKG gene (NEMO) in Xq28, inherited as an X-linked dominant trait",
"Incontinentia pigmenti (IP) or Bloch-Sulzberger syndrome (BSS) is a rare neurocutaneous disorder with a ... | [
"Incontinentia pigmenti or Bloch-Sulzberger syndrome"
] | [
"Incontinentia pigmenti (IP) is a rare neurocutaneous disorder with a frequency of 1 in 50,000 newborn, and is associated with mutations in IKBKG gene (NEMO) in Xq28, inherited as an X-linked dominant trait",
"Mutations in the NEMO gene give rise to a heterogeneous group of disorders, including the X-linked domin... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22036144",
"http://www.ncbi.nlm.nih.gov/pubmed/19149237",
"http://www.ncbi.nlm.nih.gov/pubmed/16532398",
"http://www.ncbi.nlm.nih.gov/pubmed/18350553",
"http://www.ncbi.nlm.nih.gov/pubmed/23378396",
"http://www.ncbi.nlm.nih.gov/pubmed/22236433",
"http://www.ncbi.nlm.n... | [] | [] |
56accec70a360a5e45000003 | summary | What is ISMARA? | [
"ISMARA (Integrated System for Motif Activity Response Analysis) is a web-based tool that models gene expression or chromatin modifications in terms of genome-wide predictions of regulatory sites. Given only gene expression or chromatin state data across a set of samples as input, ISMARA identifies the key TFs and ... | [] | [
"ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs.",
"We developed a methodology that models gene expression or chromatin modifications in terms of genome-wide predictions of regulatory sites and completely automated it into a web-based tool called ISMARA (Integrated System for Mo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24515121"
] | [] | [] |
52e01f8f98d023950500000f | yesno | Is it possible to purify pseudopodia to be used for proteomic analysis? | [
"Pseudopodia can be purified, using different strategies, in order to be used in proteomic studies."
] | [
"yes"
] | [
"we developed an approach to biochemically isolate the pseudopodium from the cell body using 3.0-micrometer porous filters for large-scale quantitative proteomic and phosphoproteomic analysis.",
"Recent work using unique subcellular fractionation methodologies combined with spatial genomic, proteomic, and phospho... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22980730",
"http://www.ncbi.nlm.nih.gov/pubmed/21909922",
"http://www.ncbi.nlm.nih.gov/pubmed/23313222",
"http://www.ncbi.nlm.nih.gov/pubmed/22751350",
"http://www.ncbi.nlm.nih.gov/pubmed/17712138"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#note",
"s": "http://linkedlifedata.com/resource/umls/label/A0107210",
"o": "MeSH"
},
{
"p": "http://linkedlifedata.com/resource/umls/altMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C0033827",
"o": "http://linkedlifedata.com/resour... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011554",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D040901"
] |
56cad5df5795f9a73e000020 | summary | Where does TDP43 localize in ALS neurons? | [
"In control motor neurons, TDP43 was almost exclusively nuclear, whereas in ALS spinal motor neurons, TDP43 was predominantly localized to the cytosol and not the nucleus. ",
"In control motor neurons, TDP43 was almost exclusively nuclear, whereas in ALS spinal motor neurons, TDP43 was predominantly localized to... | [] | [
"In control motor neurons, TDP43 was almost exclusively nuclear, whereas in ALS spinal motor neurons, TDP43 was predominantly localized to the cytosol and not the nucleus. ",
"The FUS/TLS protein binds to RNA, functions in diverse processes, and is normally located predominantly in the nucleus. In contrast, the m... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19251627",
"http://www.ncbi.nlm.nih.gov/pubmed/17481916"
] | [] | [] |
52f89fd32059c6d71c000051 | list | List interaction partners for the protein GATA1. | [
"GATA-1 interact with factor Gfi-1b, the repressive MeCP1 complex, the chromatin remodeling ACF/WCRF complex, FOG-1, TAL-1, Ldb-1 and LMO2-C.",
"GATA1 interacts with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex, the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/... | [
"Gfi-1b",
"MeCP1",
"MeCP1 complex",
"ACF/WCRF complex",
"FOG-1",
"TAL-1",
"Ldb1",
"Ldb-1",
"LMO2-C",
"PIAS3",
"RUNX1",
"Ski",
"EKLF",
"SP1",
"CBP/p300",
"PU.1"
] | [
"Our work describes, for the first time, distinct GATA-1 interactions with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex, and the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/FOG-1 and GATA-1/TAL-1 complexes. We also provide evidence that distinct GATA-1 complexes... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16339652",
"http://www.ncbi.nlm.nih.gov/pubmed/21532337",
"http://www.ncbi.nlm.nih.gov/pubmed/17108004",
"http://www.ncbi.nlm.nih.gov/pubmed/18844071",
"http://www.ncbi.nlm.nih.gov/pubmed/12032775",
"http://www.ncbi.nlm.nih.gov/pubmed/20959602",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/GATA1_RAT",
"http://www.uniprot.org/uniprot/GATA1_MOUSE",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D025941",
"http://www.uniprot.org/uniprot/GATA1_ARATH",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&ter... |
55263a1898daae017c000001 | yesno | Is farnesoid X receptor (FXR) a nuclear receptor? | [
"Yes, farnesoid X receptor (FXR) is a nuclear receptor."
] | [
"yes"
] | [
"Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism",
" Farnesoid X receptor (FXR) is an ascending target for metabolic... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23784309",
"http://www.ncbi.nlm.nih.gov/pubmed/23688559",
"http://www.ncbi.nlm.nih.gov/pubmed/24068255",
"http://www.ncbi.nlm.nih.gov/pubmed/23772048",
"http://www.ncbi.nlm.nih.gov/pubmed/24037988",
"http://www.ncbi.nlm.nih.gov/pubmed/23651738",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/NR1H4_HUMAN",
"http://www.uniprot.org/uniprot/NR1H4_MOUSE",
"http://www.uniprot.org/uniprot/NR1H4_BOVIN",
"http://www.biosemantics.org/jochem#4250490",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004879",
"http://www.uniprot.org/uniprot/NR1H4_RAT",
... |
533675ced6d3ac6a34000056 | list | What histone variants play a role in the DNA damage reponse? | [
"Mostly H2A.X, but H2A.Z and H1R have also been associated to DNA damage"
] | [
"H2A.X",
"H2A.Z",
"H1R"
] | [
"H2A.Z is an evolutionarily ancient and highly conserved H2A variant that regulates processes ranging from gene expression to the DNA damage response",
"activation of DNA damage checkpoints (ataxia telangiectasia mutated (ATM) and H2A histone family, member X (H2AFX (H2AFX)))",
"the specialization imparted by h... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18296106",
"http://www.ncbi.nlm.nih.gov/pubmed/20407219",
"http://www.ncbi.nlm.nih.gov/pubmed/11893489",
"http://www.ncbi.nlm.nih.gov/pubmed/19234522",
"http://www.ncbi.nlm.nih.gov/pubmed/21901086",
"http://www.ncbi.nlm.nih.gov/pubmed/16951256",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974",
"http://www.uniprot.org/uniprot/H2BV_BOVIN",
"http://www.biosemantics.org/jochem#4278518",
"http://www.uniprot.org/uniprot/H2AZ_CHAGB",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004249",
"h... |
52f895602059c6d71c000040 | list | List tele monitoring applications of miniaturised sensors | [
"Home-polysomnography (HPSG)\nBody weight\nBlood pressure control\nHeart failure control\nVital signs - disaster relief, dangerous outdoor sports and adventure monitoring, and antiterrorism activities.\nTelemetric fetal home monitoring system for recording the trans-abdominal fetal heart signal and the uterine cont... | [
"Sleep monitoring",
"Body weight",
"Blood pressure control",
"Heart failure control",
"vital signs",
"fetal heart signal",
"uterine contractions",
"Electrocardiograms",
"ECG",
"Temperature",
"Oxygen saturation",
"SaO2",
"breath rate",
"Step-counting",
"Falls detector"
] | [
"Home-polysomnography (HPSG) has been proposed as a cost-effective alternative for obstructive sleep apnea (OSA) diagnosis. We assessed, in a feasibility study, whether telematic transmission using the Dream® and Sleepbox® technologies was associated with low HPSG failure rate",
" In this study, we monitored remo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18002293",
"http://www.ncbi.nlm.nih.gov/pubmed/18002454",
"http://www.ncbi.nlm.nih.gov/pubmed/20925563",
"http://www.ncbi.nlm.nih.gov/pubmed/21250829",
"http://www.ncbi.nlm.nih.gov/pubmed/17272161",
"http://www.ncbi.nlm.nih.gov/pubmed/20875149",
"http://www.ncbi.nlm.n... | [
{
"p": "http://data.linkedct.org/resource/linkedct/intervention_type",
"s": "http://data.linkedct.org/resource/intervention/46062",
"o": "Other"
},
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://data.linkedct.org/resource/intervention/46062",
"o": "Intervention #46062 ... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008904"
] |
553c9f96f32186855800000c | factoid | How are ultraconserved elements called when they form clusters? | [
"Ultraconserved non-coding elements (UCNEs) are organized as large clusters, so-called gene regulatory blocks (GRBs) around key developmental genes. Their molecular functions and the reasons for their high degree of conservation remain enigmatic."
] | [
"gene regulatory blocks (GRBs)"
] | [
"We were wondering whether this approach could provide insights about utlraconserved non-coding elements (UCNEs). These elements are organized as large clusters, so-called gene regulatory blocks (GRBs) around key developmental genes. Their molecular functions and the reasons for their high degree of conservation re... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22962458",
"http://www.ncbi.nlm.nih.gov/pubmed/23193254"
] | [] | [] |
56f3f2072ac5ed1459000018 | summary | What is the basis of the methodology of "functional class scoring" (FCS) for the analysis of gene expression data? | [
"The second method, \"functional class scoring\" (FCS), examines the statistical distribution of individual gene scores among all genes in the gene ontology class and does not involve an initial gene selection step.",
"Functional class scoring (FCS), examines the statistical distribution of individual gene scores... | [] | [
"The second method, \"functional class scoring\" (FCS), examines the statistical distribution of individual gene scores among all genes in the gene ontology class and does not involve an initial gene selection step.",
"We aimed at examining such discrepancies on the level of apparently affected biologically relat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24565001",
"http://www.ncbi.nlm.nih.gov/pubmed/25161229",
"http://www.ncbi.nlm.nih.gov/pubmed/16317079",
"http://www.ncbi.nlm.nih.gov/pubmed/18990722",
"http://www.ncbi.nlm.nih.gov/pubmed/16895928",
"http://www.ncbi.nlm.nih.gov/pubmed/16280084",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D063990",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015870",
"http://amigo.geneontology.org/amigo/term/GO:0010467",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact... |
53173fc5b166e2b806000006 | summary | What is the Timothy syndrome? | [
"Timothy syndrome is a multisystem disorder characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form caused by mutations in a transcript variant of the same gene. Cardiac findings include a rate-corrected QT interval of between 480 ms a... | [] | [
"A point mutation in the gene encoding Ca(V)1.2 causes Timothy syndrome, a neurodevelopmental disorder associated with autism spectrum disorders (ASDs).",
"o circumvent this issue, we have developed a method using human-induced pluripotent stem cells to generate cardiomyocytes from individuals with Timothy syndro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23690510",
"http://www.ncbi.nlm.nih.gov/pubmed/21915623",
"http://www.ncbi.nlm.nih.gov/pubmed/17467634",
"http://www.ncbi.nlm.nih.gov/pubmed/20301577",
"http://www.ncbi.nlm.nih.gov/pubmed/18536931",
"http://www.ncbi.nlm.nih.gov/pubmed/22999068",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:0060173"
] |
56cf36263975bb303a000007 | factoid | Which disease has been associated to a disruptive ALX1 protein? | [
"Disruption of ALX1 causes extreme microphthalmia and severe facial clefting: expanding the spectrum of autosomal-recessive ALX-related frontonasal dysplasia."
] | [
"frontonasal dysplasia"
] | [
"Disruption of ALX1 causes extreme microphthalmia and severe facial clefting: expanding the spectrum of autosomal-recessive ALX-related frontonasal dysplasia.",
"In the second family we identified a homozygous donor-splice-site mutation (c.531+1G>A) in the ALX1 gene, providing evidence that complete loss of funct... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20451171",
"http://www.ncbi.nlm.nih.gov/pubmed/20627960",
"http://www.ncbi.nlm.nih.gov/pubmed/8673125",
"http://www.ncbi.nlm.nih.gov/pubmed/15728667",
"http://www.ncbi.nlm.nih.gov/pubmed/12390248",
"http://www.ncbi.nlm.nih.gov/pubmed/24376213",
"http://www.ncbi.nlm.ni... | [] | [] |
517170c48ed59a060a00000d | factoid | How many selenoproteins are encoded in the human genome? | [
"25. 15kDa, DI1, DI2, DI3, GPx1, GPx2, GPx3, GPx4, GPx6, SelH, SelI, SelK, SelM, SelN, SelO, SelP, SelR, SelS, SPS2, SelT, TR1, TR2, TR3, SelV and SelW."
] | [
"25"
] | [
"The human selenoproteome consists of 25 selenoproteins."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/22943432",
"http://www.ncbi.nlm.nih.gov/pubmed/12775843",
"http://www.ncbi.nlm.nih.gov/pubmed/18174224",
"http://www.ncbi.nlm.nih.gov/pubmed/15843685"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051140"
] |
534eb34b288f4dae47000002 | factoid | In which process Src, Cortactin and MT1-MMP are playing an essential role? | [
"Src was shown to be required for invadopodia formation and function, whereas Cortactin was found to regulate cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. Finally, membrane type 1 matrix metalloproteinase (MT1-MMP) was demostrated as the key invadopodial enzyme respon... | [
"Src, Cortactin and MT1-MMP play an essential role in the formation and function of invadopodia."
] | [
"Further investigation into the underlying molecular mechanisms revealed that the levels of key modulators of invadopodium maturation, including c-Src kinase, cortactin, and membrane type 1-matrix metalloproteinase (MT1-MMP) decreased when cells were treated with 6-shogaol or pterostilbene. ",
"These data suggest... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16540652",
"http://www.ncbi.nlm.nih.gov/pubmed/22039045",
"http://www.ncbi.nlm.nih.gov/pubmed/20937825",
"http://www.ncbi.nlm.nih.gov/pubmed/23417847",
"http://www.ncbi.nlm.nih.gov/pubmed/17446433",
"http://www.ncbi.nlm.nih.gov/pubmed/19704022"
] | [] | [
"http://www.uniprot.org/uniprot/SRC_HUMAN",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019061",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053511",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=... |
5710e131a5ed216440000001 | factoid | In which yeast chromosome does the rDNA cluster reside? | [
"Chromosome XII context is important for rDNA function in yeast",
"The rDNA cluster in Saccharomyces cerevisiae is located 450 kb from the left end and 610 kb from the right end of chromosome XII and consists of approximately 150 tandemly repeated copies of a 9.1 kb rDNA unit.",
"Condensation of a unique region... | [
"chromosome XII",
"chromosome 12"
] | [
"Chromosome XII context is important for rDNA function in yeast",
"The rDNA cluster in Saccharomyces cerevisiae is located 450 kb from the left end and 610 kb from the right end of chromosome XII and consists of approximately 150 tandemly repeated copies of a 9.1 kb rDNA unit",
"To explore the biological signif... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8371105",
"http://www.ncbi.nlm.nih.gov/pubmed/16738130",
"http://www.ncbi.nlm.nih.gov/pubmed/24333410",
"http://www.ncbi.nlm.nih.gov/pubmed/8175878",
"http://www.ncbi.nlm.nih.gov/pubmed/9169867"
] | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0005694",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012441"
] |
5713394af9287de436000001 | summary | Which is the underlying mechanism for exon skipping used to treat Duchenne muscular dystrophy? | [
"Antisense-mediated exon skipping therapy is a promising therapeutic approach that uses short DNA-like molecules called antisense oligonucleotides (AOs) to skip over/splice out the mutated part of the gene to produce a shortened but functional dystrophin protein. Many Duchenne Muscular Dystrophy patients need exon ... | [] | [
"Antisense-mediated exon skipping therapy is a promising therapeutic approach that uses short DNA-like molecules called antisense oligonucleotides (AOs) to skip over/splice out the mutated part of the gene to produce a shortened but functional dystrophin protein",
"many DMD patients need exon skipping of multiple... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19140108",
"http://www.ncbi.nlm.nih.gov/pubmed/22086232",
"http://www.ncbi.nlm.nih.gov/pubmed/23521559",
"http://www.ncbi.nlm.nih.gov/pubmed/20150322",
"http://www.ncbi.nlm.nih.gov/pubmed/24380394",
"http://www.ncbi.nlm.nih.gov/pubmed/17612397"
] | [] | [] |
515b1eccd24251bc050000af | summary | What is the advantage of using long nano columns in proteomics? | [
"The longer the columns, the longer gradients are applied and finally more proteins (increased peak capacity) are identified in a complex proteomic experiment"
] | [] | [
"Our results indicate that this simplified one-shot proteomics approach with long monolithic columns is advantageous for rapid, deep, sensitive, and reproducible proteome analysis.",
"Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot NanoLC-MS/MS analysis with meter-scale monoli... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20382391",
"http://www.ncbi.nlm.nih.gov/pubmed/22021278",
"http://www.ncbi.nlm.nih.gov/pubmed/21751368",
"http://www.ncbi.nlm.nih.gov/pubmed/22728655",
"http://www.ncbi.nlm.nih.gov/pubmed/15058572",
"http://www.ncbi.nlm.nih.gov/pubmed/23210603",
"http://www.ncbi.nlm.n... | [] | [] |
56e2acfe51531f7e33000014 | factoid | During which stage of the cell cycle is cohesin deposited on the yeast genome? | [
"In the budding yeast, cohesin is loaded onto the chromosome during the late G1 phase, establishes sister chromatid cohesion concomitant with DNA replication, and dissociates by the telophase.",
"In the budding yeast, cohesin is loaded onto the chromosome during the late G1 phase, establishes sister chromatid coh... | [
"S-phase"
] | [
"In the budding yeast, cohesin is loaded onto the chromosome during the late G1 phase, establishes sister chromatid cohesion concomitant with DNA replication, and dissociates by the telophase. ",
"Sister chromatid cohesion is mediated by cohesin, but the process of cohesion establishment during S-phase is still e... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11069892",
"http://www.ncbi.nlm.nih.gov/pubmed/17670945",
"http://www.ncbi.nlm.nih.gov/pubmed/15870297",
"http://www.ncbi.nlm.nih.gov/pubmed/24778232",
"http://www.ncbi.nlm.nih.gov/pubmed/18178375",
"http://www.ncbi.nlm.nih.gov/pubmed/11081625",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002453",
"http://amigo.geneontology.org/amigo/term/GO:0007049"
] |
517818508ed59a060a000035 | factoid | Which is the neurodevelopmental disorder associated to mutations in the X- linked gene mecp2? | [
"The neurodevelopmental disorder named Rett syndrome, originally termed as cerebroatrophic hyperammonemia. Although most exclusively affects females, has also been found in male patients."
] | [
"Rett syndrome"
] | [
"Rett syndrome is caused by mutations in the gene coding for methyl CpG-binding protein 2 (MeCP2).",
"Rett syndrome is one of the most common causes of complex disability in girls. It is characterized by early neurological regression that severely affects motor, cognitive and communication skills, by autonomic dy... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23449173",
"http://www.ncbi.nlm.nih.gov/pubmed/11738860",
"http://www.ncbi.nlm.nih.gov/pubmed/11269512",
"http://www.ncbi.nlm.nih.gov/pubmed/17387578",
"http://www.ncbi.nlm.nih.gov/pubmed/12111643",
"http://www.ncbi.nlm.nih.gov/pubmed/19495527",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051783",
"http://www.uniprot.org/uniprot/MECP2_MACFA"
] |
517541e08ed59a060a00002a | summary | What is the treatment of Riedel disease (thyroiditis)? | [
"Riedel thyroiditis is a rare disorder related to a systemic extracervical fibrotic process of unknown origin. The tratment of choice is the surgical treatment: Corticosteroids may be also useful"
] | [] | [
"IFT often is associated with a systemic extracervical fibrotic process and tobacco use. Attempted thyroid resection often results in postoperative complications. Long-term follow-up showed no deaths fro",
"Riedel's invasive fibrous thyroiditis is a rare disorder of unknown origin with progressive extension and i... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11014014",
"http://www.ncbi.nlm.nih.gov/pubmed/21568724",
"http://www.ncbi.nlm.nih.gov/pubmed/3287769",
"http://www.ncbi.nlm.nih.gov/pubmed/8120524",
"http://www.ncbi.nlm.nih.gov/pubmed/22210556"
] | [] | [] |
56a8ee75a17756b72f000007 | factoid | What is the link between Dax1 and Esrrb? | [
"Dax1 associates with Esrrb and regulates its function in embryonic stem cells",
"Dax1 associates with Esrrb and regulates its function in embryonic stem cells."
] | [
"Dax1 associates with Esrrb and regulates its function in embryonic stem cells."
] | [
"Dax1 associates with Esrrb and regulates its function in embryonic stem cells",
"Nuclear hormone receptor Dax1 is one of the crucial factors in the network. Here, we identified an orphan nuclear receptor, Esrrb (estrogen-related receptor beta), as a Dax1-interacting protein. Interaction of Dax1 and Esrrb was med... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23508100"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D057137"
] |
56d04a533975bb303a000010 | factoid | What is dovitinib? | [
"Dovitinib (TKI258) is a tyrosine kinase receptor inhibitor with potent activity against fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR)."
] | [
"tyrosine kinase receptor inhibitor"
] | [
"This phase 2 study investigated the efficacy and safety of dovitinib (TKI258), a receptor tyrosine kinase inhibitor with potent activity against fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR), in locally advanced or metastatic thyroid cancer patients",
"Dispositi... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23228017",
"http://www.ncbi.nlm.nih.gov/pubmed/24908540",
"http://www.ncbi.nlm.nih.gov/pubmed/21521775",
"http://www.ncbi.nlm.nih.gov/pubmed/23443805",
"http://www.ncbi.nlm.nih.gov/pubmed/24495750",
"http://www.ncbi.nlm.nih.gov/pubmed/21976540",
"http://www.ncbi.nlm.n... | [] | [] |
5319a752b166e2b806000027 | yesno | Are DNA helicases involved in progeroid syndromes? | [
"Yes, mutations in genes coding for DNA helicases were found to induce progeroid syndromes, such as Werner syndrome (WS) or Bloom syndrome (BS)."
] | [
"yes"
] | [
"Among these syndromes, relevant advances have recently been made in Werner syndrome, one of several progeroid syndromes characterized by defective DNA helicases,",
"Progeroid syndromes (PSs) constitute a group of disorders characterized by clinical features mimicking physiological aging at an early age.",
"How... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10984715",
"http://www.ncbi.nlm.nih.gov/pubmed/17131053",
"http://www.ncbi.nlm.nih.gov/pubmed/16987878",
"http://www.ncbi.nlm.nih.gov/pubmed/15743670",
"http://www.ncbi.nlm.nih.gov/pubmed/15734684"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004265",
"http://www.disease-ontology.org/api/metadata/DOID:225",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033202",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D00... |
551829a76487737b43000009 | list | List the diseases for which there are point-of-care breath tests | [
"Point of care breath tests are available for lung cancer, pulmonary embolism, respiratory distress syndrome, methanol intoxication, kidney diseases, liver diseases, Helicobacter pylori infection, asthma, sepsis, heart failure, diabetes and tuberculosis."
] | [
"lung cancer",
"pulmonary embolism",
"respiratory distress syndrome",
"methanol intoxication",
"kidney diseases",
"liver diseases",
"Helicobacter pylori infection",
"asthma",
"sepsis",
"heart failure",
"diabetes",
"tuberculosis"
] | [
"Additionally, we try to clarify controversial issues concerning possible experimental malpractice in the field, and propose ways to translate the basic science results as well as the mechanistic understanding to tools (sensors) that could serve as point-of-care diagnostics of cancer.",
"Point of care monitoring ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20805989",
"http://www.ncbi.nlm.nih.gov/pubmed/20973886",
"http://www.ncbi.nlm.nih.gov/pubmed/18657870",
"http://www.ncbi.nlm.nih.gov/pubmed/15963485",
"http://www.ncbi.nlm.nih.gov/pubmed/23462278",
"http://www.ncbi.nlm.nih.gov/pubmed/16377649",
"http://www.ncbi.nlm.n... | [] | [] |
56c1d85eef6e394741000035 | yesno | Is there association of matrix metalloproteinases with behaviour of pituitary adenomas? | [
"Yes, there is evidence to suggest that matrix metalloproteinases are associated with more aggressive of pituitary adenomas."
] | [
"yes"
] | [
"While detailed histological subtyping remains the best independent predictor of aggressive behavior in the majority of cases, evidence suggests that the additional analyses of FGFR4, MMP, PTTG, Ki-67, p53, and deletions in chromosome 11 may contribute to decisions concerning management of aggressive pituitary aden... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10634397",
"http://www.ncbi.nlm.nih.gov/pubmed/10598711",
"http://www.ncbi.nlm.nih.gov/pubmed/12508658",
"http://www.ncbi.nlm.nih.gov/pubmed/18493720",
"http://www.ncbi.nlm.nih.gov/pubmed/16172741",
"http://www.ncbi.nlm.nih.gov/pubmed/16167532",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010911",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020782",
"http://www.disease-ontology.org/api/metadata/DOID:3829"
] |
554a0cadf35db7552600000f | summary | What is the evolutionary process described by the "Muller's ratchet" model? | [
"The vast majority of mutations are deleterious and are eliminated by purifying selection. Yet in finite populations, purifying selection cannot completely prevent the accumulation of deleterious mutations. Muller's ratchet is a paradigmatic model for the accumulation of deleterious mutations in a population of fin... | [] | [
"Muller's ratchet is a paradigmatic model for the accumulation of deleterious mutations in a population of finite size. A click of the ratchet occurs when all individuals with the least number of deleterious mutations are lost irreversibly due to a stochastic fluctuation.",
"Population bottlenecks can have major ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/14741203",
"http://www.ncbi.nlm.nih.gov/pubmed/11164046",
"http://www.ncbi.nlm.nih.gov/pubmed/16957730",
"http://www.ncbi.nlm.nih.gov/pubmed/8380072",
"http://www.ncbi.nlm.nih.gov/pubmed/8365659",
"http://www.ncbi.nlm.nih.gov/pubmed/20657178",
"http://www.ncbi.nlm.nih... | [] | [] |
534abe8aaeec6fbd07000013 | factoid | Which heat shock protein is found to be upregulated during Hsp90 inhibition? | [
"HSP90 inhibition was found to be associated with induction of HSP70 expression."
] | [
"HSP70"
] | [
"HSP90 inhibition was associated with decreased neuroendocrine ErbB and IGF-I receptor expression, decreased Erk and Akt phospho-rylation and the induction of HSP70 expression.",
"Inhibition of Hsp90 upregulated the expression of Hsp70 and Hsp70-bound Nox2, 5 and promoted degradation.",
"Conversely, inhibition ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23023377",
"http://www.ncbi.nlm.nih.gov/pubmed/24100469",
"http://www.ncbi.nlm.nih.gov/pubmed/20015528"
] | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006986",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018841",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018840",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field... |
571f33bd0fd6f91b68000003 | factoid | Which gene is responsible for the development of Sotos syndrome? | [
"Sotos syndrome (SoS) is a multiple anomaly, congenital disorder characterized by overgrowth, macrocephaly, distinctive facial features and variable degree of intellectual disability. Haploinsufficiency of the NSD1 gene at 5q35.3, arising from 5q35 microdeletions, point mutations, and partial gene deletions, accoun... | [
"NSD1 gene"
] | [
"Sotos syndrome is a well-known overgrowth syndrome characterized by excessive growth during childhood, macrocephaly, distinctive facial appearance and learning disability. This disorder is caused by mutations or deletions in NSD1 gene",
"Sotos syndrome (SoS) is a multiple anomaly, congenital disorder characteriz... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25510705",
"http://www.ncbi.nlm.nih.gov/pubmed/25852445",
"http://www.ncbi.nlm.nih.gov/pubmed/21567906",
"http://www.ncbi.nlm.nih.gov/pubmed/23190751",
"http://www.ncbi.nlm.nih.gov/pubmed/20420030",
"http://www.ncbi.nlm.nih.gov/pubmed/24192683",
"http://www.ncbi.nlm.n... | [] | [] |
53617eeb7d100faa0900000a | factoid | What is the name for anorexia in gymnasts? | [
"Anorexia athletica"
] | [
"Anorexia Athletica"
] | [
"Elite Rhythmic Gymnasts (RGs) constitute a unique metabolic model and they are prone to developing Anorexia Athletica.",
"We studied 13 female juvenile elite gymnasts with anorexia athletica (AA"
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/10551340",
"http://www.ncbi.nlm.nih.gov/pubmed/24240086"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006173",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000855",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000856"
] |
515def40298dcd4e51000028 | yesno | Is Vitamin D deficiency in pregnant women associated with gestational diabetes? | [
"Yes, there are multiple studies reporting an association between low VitD in pregnancy and impaired glucose tolerance, but it is not entirely clear if this translates directly to the increased risk of Gestational diabetes or via maternal obesity and/or genetic polymorphisms."
] | [
"yes"
] | [
"Insufficient serum levels of 25-OHD were associated with gestational diabetes (pooled odds ratio 1.49, 95% confidence interval 1.18 to 1.89",
"Vitamin D insufficiency is associated with an increased risk of gestational diabetes, p",
"Therefore, it is important to identify potentially modifiable risk factors fo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23452283",
"http://www.ncbi.nlm.nih.gov/pubmed/20962313",
"http://www.ncbi.nlm.nih.gov/pubmed/19692182",
"http://www.ncbi.nlm.nih.gov/pubmed/22548949",
"http://www.ncbi.nlm.nih.gov/pubmed/18544105",
"http://www.ncbi.nlm.nih.gov/pubmed/14633808",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:11714",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016640",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002762",
"http://www.biosemantics.org/jochem#4250136",
"http://www.biosema... |
52bf209303868f1b0600001a | list | What are the indications for alteplase? | [
"Intravenous alteplase (recombinant tissue plasminogen activator) is the only approved thrombolytic agent at present indicated for acute ischaemic stoke.\nFood and Drug Administration approval of alteplase for central venous catheter (CVC) occlusions. \nAlteplase is now firmly established as a treatment of choice i... | [
"ischemic stroke",
"central venous catheter (CVC) occlusions",
"thrombolysis",
"myocardial infarction",
"acute pulmonary embolism",
"deep vein thrombosis",
"limb artery occlusions",
"Ischaemic Stroke",
"Acute Myocardial Infarction",
"AMI",
"MI",
"Pulmonary Thromboembolism",
"Vein Thrombosis"... | [
"In Japan, intravenous alteplase, a recombinant tissue-type plasminogen activator (rt-PA), was approved for an indication of ischemic stroke in 2005 on the basis of the results of a clinical trial with a unique dose of the drug (0.6 mg/kg). ",
"Alteplase appears to show efficacy for treatment of thrombus-related ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19804685",
"http://www.ncbi.nlm.nih.gov/pubmed/10172049",
"http://www.ncbi.nlm.nih.gov/pubmed/23336348",
"http://www.ncbi.nlm.nih.gov/pubmed/7579782",
"http://www.ncbi.nlm.nih.gov/pubmed/23727456",
"http://www.ncbi.nlm.nih.gov/pubmed/12450926",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://data.linkedct.org/resource/linkedct/intervention_type",
"s": "http://data.linkedct.org/resource/intervention/2894",
"o": "Drug"
},
{
"p": "http://data.linkedct.org/resource/linkedct/intervention_name",
"s": "http://data.linkedct.org/resource/intervention/2894",
"o": "Cathf... | [
"http://www.uniprot.org/uniprot/TPA_HUMAN",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010959",
"http://www.biosemantics.org/jochem#4002037"
] |
55152bd246478f2f2c000002 | list | List scaffold proteins of the ERK signaling pathway. | [
"Originally identified in yeast, scaffold proteins are now recognized to contribute to the specificity of MEK/ERK pathways in mammalian cells. These scaffolds include kinase suppressor of Ras (KSR), beta-arrestin, MEK partner-1 (MP-1), Sef and IQ motif-containing GTPase-activating protein 1(IQGAP1). Human disc-larg... | [
"Human disc-large homolog",
"hDlg",
"caveolin-1",
"IQ motif-containing GTPase-activating protein 1",
"IQGAP1",
"kinase suppressor of Ras",
"KSR",
"MEK partner-1",
"MP-1",
"beta-arrestin",
"Sef",
"14-3-3",
"mitogen-activated protein kinase organizer 1"
] | [
"Human disc-large homolog (hDlg), also known as synapse-associated protein 97, is a scaffold protein, a member of the membrane-associated guanylate kinase family, implicated in neuronal synapses and epithelial-epithelial cell junctions whose expression and function remains poorly characterized in most tissues, part... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23755307",
"http://www.ncbi.nlm.nih.gov/pubmed/24101133",
"http://www.ncbi.nlm.nih.gov/pubmed/23987506",
"http://www.ncbi.nlm.nih.gov/pubmed/21615688",
"http://www.ncbi.nlm.nih.gov/pubmed/17052209",
"http://www.ncbi.nlm.nih.gov/pubmed/22926523",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032947",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070374",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097110",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004707",
"htt... |
516c3960298dcd4e51000073 | list | Which are the families of mammalian DNA-(cytosine-5)-methyltransferases? | [
"DNA (cytosine-5)-methyltransferases catalyze the specific transfer of a methyl group to the C5 position of cytosine residues in DNA. Three families of DNA (cytosine-5)-methyltransferases have been identified in mammals: DNMT1, DNMT2 and DNMT3 (including DNMT3a, DNMT3b and DNMT3L isoforms). All of them share homol... | [
"DNMT1",
"DNMT2",
"DNMT3"
] | [
"Of the DNMTs, DNMT1 and DNMT3a are most highly expressed in postmitotic neurons.",
"DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals.",
"Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coord... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21846773",
"http://www.ncbi.nlm.nih.gov/pubmed/18367714",
"http://www.ncbi.nlm.nih.gov/pubmed/22815530",
"http://www.ncbi.nlm.nih.gov/pubmed/20838592",
"http://www.ncbi.nlm.nih.gov/pubmed/23302691",
"http://www.ncbi.nlm.nih.gov/pubmed/22133874",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/DNMT1_CHICK",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004248",
"http://www.uniprot.org/uniprot/CMT3_MAIZE",
"http://www.uniprot.org/uniprot/DNM3A_RAT",
"http://www.uniprot.org/uniprot/DNMT1_ARATH",
"http://www.uniprot.org/uniprot/D... |
54e0ac041388e8454a00000f | list | Which classes of endogenous retroelements are known to date? | [
"Endogenous retroelements fall into two distinct classes: retrotransposons containing LTRs (Long Terminal Repeats), and retrostransposons lacking LTRs."
] | [
"retrotransposons containing LTRs (Long Terminal Repeats)",
"retrostransposons lacking LTRs (Long Terminal Repeats)"
] | [
"Transposons are divided into two general classes based on their transposition intermediate (DNA or RNA). Only one subclass, the non-LTR retrotransposons, which includes the Long INterspersed Element-1 (LINE-1 or L1), is currently active in humans as indicated by 96 disease-causing insertions",
"Diversity of LTR-... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22406018",
"http://www.ncbi.nlm.nih.gov/pubmed/18636276",
"http://www.ncbi.nlm.nih.gov/pubmed/10697412"
] | [] | [] |
54e1c5d5ae9738404b00000b | summary | What is the association between proBNP serum concentrations and stroke outcomes? | [
"ProBNP serum concentrations are elevated in stroke patients relative to healthy controls. Greater proBNP serum concentrations are associated with greater stroke severity and with increased risk for unfvorable functional outcomes."
] | [] | [
"N-terminal probrain natriuretic peptide levels as a predictor of functional outcomes in patients with ischemic stroke.",
"There was a strong positive correlation between the plasma level of NT-proBNP and the National Institutes of Health Stroke Scale score (r=0.415, P=0.000). Plasma levels of NT-proBNP in patien... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23701638",
"http://www.ncbi.nlm.nih.gov/pubmed/25102374",
"http://www.ncbi.nlm.nih.gov/pubmed/16565563",
"http://www.ncbi.nlm.nih.gov/pubmed/17904063"
] | [] | [] |
570906fecf1c325851000010 | summary | What is the effect that EZH2 has on chromatin? | [
"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms",
"Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. The mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes but exhibit contrasting repressive roles. PRC2-Ezh2 cataly... | [] | [
"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms",
"Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. We report that the mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes but exhibit contrasting repressive roles.",... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19026781",
"http://www.ncbi.nlm.nih.gov/pubmed/18980972",
"http://www.ncbi.nlm.nih.gov/pubmed/24040281",
"http://www.ncbi.nlm.nih.gov/pubmed/20631058",
"http://www.ncbi.nlm.nih.gov/pubmed/19954516",
"http://www.ncbi.nlm.nih.gov/pubmed/22821416",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/EZH2_HUMAN",
"http://www.uniprot.org/uniprot/EZH2A_XENLA",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002843",
"http://www.uniprot.org/uniprot/EZH2_MOUSE",
"http://amigo.geneontology.org/amigo/term/GO:0000785",
"http://www.uniprot.org... |
52ef6da1c8da898910000011 | yesno | Does Chromatin Immunoprecipitation (ChIP) show a bias for highly expressed loci? | [
"Several issues in the processing and analysis of ChIP-chip data have not been resolved fully, including the effect of background (mock control) subtraction and normalization within and across arrays. We detected a chromatin-state bias: open chromatin regions yielded higher coverage, which led to false positives if... | [
"yes"
] | [
"However, several issues in the processing and analysis of ChIP-chip data have not been resolved fully, including the effect of background (mock control) subtraction and normalization within and across arrays",
" Proper normalization is essential for ChIP-chip experiments. The proposed normalization technique can... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24173036",
"http://www.ncbi.nlm.nih.gov/pubmed/17477493",
"http://www.ncbi.nlm.nih.gov/pubmed/22248020",
"http://www.ncbi.nlm.nih.gov/pubmed/22870189",
"http://www.ncbi.nlm.nih.gov/pubmed/24255646",
"http://www.ncbi.nlm.nih.gov/pubmed/21934668",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010467",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020224",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D059467",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field... |
5319ac18b166e2b806000030 | yesno | Is clathrin involved in E-cadherin endocytosis? | [
"E-cadherin is a central component of the adherens junction in epithelial cells and continuously undergoes endocytosis via clathrin-coated vesicles and/or caveolae depending on the cell type."
] | [
"yes"
] | [
"We demonstrated that GnT-III induced a stabilizing effect on E-cadherin at the cell membrane by inducing a delay in the turnover rate of the protein, contributing for the formation of stable and functional adherens-junctions, and further preventing clathrin-dependent E-cadherin endocytosis.",
"Conversely, GnT-V ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17298950",
"http://www.ncbi.nlm.nih.gov/pubmed/12657640",
"http://www.ncbi.nlm.nih.gov/pubmed/23671930",
"http://www.ncbi.nlm.nih.gov/pubmed/21516109",
"http://www.ncbi.nlm.nih.gov/pubmed/18331728"
] | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006897",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004705",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072583",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:... |
5150b1f4d24251bc0500006a | summary | What are the generic versions of Viagra | [
"Sildenafil Citrate and Elonza in Thailand are the generic versions of Viagra"
] | [] | [
"Sildenafil citrate (SIL)",
"generic sildenafil (Unison Laboratories, Thailand) was proved to have the same bioequivalent as in the original formula. The authors conducted a 12-week case series to study the efficacy and safety of Elonza (generic sildenafil)",
"Viagra tablets or generic versions containing silde... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21054594",
"http://www.ncbi.nlm.nih.gov/pubmed/22386826",
"http://www.ncbi.nlm.nih.gov/pubmed/21591526"
] | [] | [
"http://www.biosemantics.org/jochem#4266960"
] |
553a7a59f321868558000002 | list | List GATA-1 interacting partners as discovered with the help of the biotinylation tagging approach. | [
"Our work describes, for the first time, distinct GATA-1 interactions with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex, and the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/FOG-1 and GATA-1/TAL-1 complexes",
"Using a biotinylation tagging/proteomics approach i... | [
"Gfi-1b",
"MeCP1 complex",
"ACF/WCRF complex",
"fog-1",
"tal-1"
] | [
"Our work describes, for the first time, distinct GATA-1 interactions with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex, and the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/FOG-1 and GATA-1/TAL-1 complexes",
"We also provide evidence that distinct GATA-1 compl... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16339652",
"http://www.ncbi.nlm.nih.gov/pubmed/15920471",
"http://www.ncbi.nlm.nih.gov/pubmed/16888367",
"http://www.ncbi.nlm.nih.gov/pubmed/19196479"
] | [] | [] |
52f129d92059c6d71c000009 | list | Which diseases are associated with Alu element insertion? | [
"Diseases associated with Alu element insertion are the following: myotonic dystrophy type 2, Friedreich ataxia, spinocerebellar ataxia type 10, autosomal dominant optic atrophy, Menkes disease, hyper-IgM with immunodeficiency syndrome (HIGM), and anterior pituitary aplasia."
] | [
"myotonic dystrophy type 2",
"Friedreich ataxia",
"spinocerebellar ataxia type 10",
"autosomal dominant optic atrophy",
"Menkes disease",
"hyper-IgM with immunodeficiency syndrome (HIGM)",
"anterior pituitary aplasia",
"HNPCC",
"FAP"
] | [
"Alu elements are known to be the source of microsatellite repeats responsible for two other repeat expansion disorders: Friedreich ataxia and spinocerebellar ataxia type 10.",
"We identified an Alu-element insertion located in intron 7 of OPA1 causing an in-frame deletion of exon 8 in 18 family members.",
"Aut... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7874122",
"http://www.ncbi.nlm.nih.gov/pubmed/22723857",
"http://www.ncbi.nlm.nih.gov/pubmed/17146684",
"http://www.ncbi.nlm.nih.gov/pubmed/20157369",
"http://www.ncbi.nlm.nih.gov/pubmed/15841484",
"http://www.ncbi.nlm.nih.gov/pubmed/17178205"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004251",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020087"
] |
534e364e288f4dae47000001 | factoid | Approximately how many recombination hotspots have been found in the yeast genome? | [
"In the fission yeast genome DSBs are located within 194 prominent peaks separated on average by 65-kbp intervals of DNA that are largely free of DSBs."
] | [
"Approximately 200",
"200",
"~200"
] | [
"In the fission yeast genome DSBs are located within 194 prominent peaks separated on average by 65-kbp intervals of DNA that are largely free of DSBs",
"Most meiotic recombination is positioned at hotspots, but knowledge of the mechanisms is nebulous",
"meiotic recombination is initiated by double-strand DNA b... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18449558",
"http://www.ncbi.nlm.nih.gov/pubmed/8290959",
"http://www.ncbi.nlm.nih.gov/pubmed/17478517",
"http://www.ncbi.nlm.nih.gov/pubmed/16640774",
"http://www.ncbi.nlm.nih.gov/pubmed/18682829",
"http://www.ncbi.nlm.nih.gov/pubmed/19557188"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#broader",
"s": "http://linkedlifedata.com/resource/geneontology/id/GO:0010844",
"o": "http://linkedlifedata.com/resource/geneontology/id/GO:0003677"
},
{
"p": "http://www.w3.org/2004/02/skos/core#prefLabel",
"s": "http://linkedlifedata.com/resource... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015003",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006312",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010844",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+... |
56f55cc809dd18d46b000008 | summary | How could iPSCs be used for the treatment of diabetes? | [
"One of the promising approaches to cure diabetes is to use induced PCSs (iPSCs) and to differentiate them into insulin-secreting β cells. The induction of iPSC differentiation into insulin-secreting cells can be achieved in several ways, such as with the use of microRNAs, or adenoviral transfection with selected g... | [] | [
"Human induced pluripotent stem cells (hiPSCs) have raised the possibility that patient-specific insulin-secreting cells might be derived from somatic cells through cell fate reprogramming.",
"We demonstrated for the first time that miRNAs might be ideal substitutes to induce pancreatic differentiation in hiPSCs.... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22512788",
"http://www.ncbi.nlm.nih.gov/pubmed/24035588",
"http://www.ncbi.nlm.nih.gov/pubmed/21060967",
"http://www.ncbi.nlm.nih.gov/pubmed/25479728",
"http://www.ncbi.nlm.nih.gov/pubmed/24794627",
"http://www.ncbi.nlm.nih.gov/pubmed/23197849",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D048909",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016640",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003921"
] |
533ea8fcc45e133714000010 | factoid | What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins? | [
"SECIS (selenocysteine insertion sequence)"
] | [
"SECIS"
] | [
"stem-loop structure called the selenocysteine incorporating sequence (SECIS)",
"3'-UTR mRNA stem-loop termed SElenoCysteine Insertion Sequence (SECIS)",
"Sec is inserted by a specific translational machinery that recognizes a stem-loop structure, the SECIS element",
"Selenocysteine Insertion Sequence (SECIS)... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19467292",
"http://www.ncbi.nlm.nih.gov/pubmed/8601283",
"http://www.ncbi.nlm.nih.gov/pubmed/17470795",
"http://www.ncbi.nlm.nih.gov/pubmed/8344267",
"http://www.ncbi.nlm.nih.gov/pubmed/24251578",
"http://www.ncbi.nlm.nih.gov/pubmed/11092556",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055029",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051149",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035613",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field... |
515d9a42298dcd4e5100000d | yesno | Is Propofol used for short-term sedation? | [
"Yes. Propofol is the most frequently used sedating agent for patients with expected duration of ICU admission less than 24 hours. There are numerous studies of its efficacy and comparisons with other sedatives."
] | [
"yes"
] | [
"The current study explores the incidence and content of dreaming during short-term sedation with sevoflurane or propofo",
"Propofol is the sedative most frequently used for short-term sedation and the weaning phase, whereas benzodiazepines are the preferred substances for medium- and long-term sedation.",
"Per... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21257635",
"http://www.ncbi.nlm.nih.gov/pubmed/19189080",
"http://www.ncbi.nlm.nih.gov/pubmed/1636917",
"http://www.ncbi.nlm.nih.gov/pubmed/23155249",
"http://www.ncbi.nlm.nih.gov/pubmed/10150552",
"http://www.ncbi.nlm.nih.gov/pubmed/10502909",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.biosemantics.org/jochem#4277106",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015742",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016292"
] |
55192f20622b194345000014 | list | Which proteins are the different members of the NF-kappaB family of transcription factors? | [
"Nuclear factor kappa B (NFκB) is a dimeric transcription factor comprised of five family members RelA (p65), RelB, c-Rel, NF-kB1/p50 and NF-kB2/p52."
] | [
"RelA",
"p65",
"RelB",
"c-Rel",
"NF-kB1/p50",
"NF-kB2/p52"
] | [
"The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel-B, NF-kappaB/p50 and NF-kappaB2/p52 .",
"Nuclear factor kappa B (NFκB) is a dimeric transcription factor comprised of five family members RelA (p65), Rel... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21122287",
"http://www.ncbi.nlm.nih.gov/pubmed/22405852",
"http://www.ncbi.nlm.nih.gov/pubmed/9129142",
"http://www.ncbi.nlm.nih.gov/pubmed/9950430"
] | [] | [
"http://www.biosemantics.org/jochem#4263986",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016328"
] |
571e417bbb137a4b0c00000a | list | What are the symptoms of Rotor syndrome? | [
"Rotor syndrome is characterized by conjugated hyperbilirubinemia, coproporphyrinuria, and near-absent hepatic uptake of anionic diagnostics."
] | [
"conjugated hyperbilirubinemia",
"coproporphyrinuria",
"near-absent hepatic uptake of anionic diagnostics"
] | [
"The mechanistic basis of bilirubin excretion and hyperbilirubinemia syndromes is largely understood, but that of Rotor syndrome, an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, coproporphyrinuria, and near-absent hepatic uptake of anionic diagnostics, has remained enigmatic. ",
"[... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11972401",
"http://www.ncbi.nlm.nih.gov/pubmed/17464171",
"http://www.ncbi.nlm.nih.gov/pubmed/22232210",
"http://www.ncbi.nlm.nih.gov/pubmed/20955959"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A0067659",
"o": "D006933"
}
] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006932",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006933"
] |
533c3871c45e133714000007 | yesno | Does splicing occur co-transcriptionally? | [
"The consensus view, based on four organisms, is that the majority of splicing events take place co-transcriptionally in most cells and tissues. RNA processing events that take place on the transcribed pre-mRNA include capping, splicing, editing, 3' processing, and polyadenylation. Most of these processes occur co-... | [
"yes"
] | [
"Researchers working in multiple model organisms - notably yeast, insects and mammalian cells - have shown that pre-mRNA can be spliced during the process of transcription (i.e. co-transcriptionally), as well as after transcription termination (i.e. post-transcriptionally)",
"The consensus view, based on four org... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22326677",
"http://www.ncbi.nlm.nih.gov/pubmed/22022255",
"http://www.ncbi.nlm.nih.gov/pubmed/22955974",
"http://www.ncbi.nlm.nih.gov/pubmed/19710184",
"http://www.ncbi.nlm.nih.gov/pubmed/19656867",
"http://www.ncbi.nlm.nih.gov/pubmed/16440002",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012326",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045292"
] |
52fa73e82059c6d71c000059 | list | List the existing methods for genetic manipulation of cells. | [
"Genetic engineering, also called genetic modification, is the direct manipulation of an organism's genome using biotechnology. New DNA may be inserted in the host genome by first isolating and copying the genetic material of interest using molecular cloning methods to generate a DNA sequence, or by synthesizing th... | [
"Agrobacterium-mediated delivery",
"direct delivery methods",
"methods using plant artificial chromosomes",
"site-directed plasmid mutagenesis",
"combined use of Red/ET recombination and unique restriction site elimination",
"Bacterial artificial chromosomes (BACs)",
"direct in vitro transposition of vi... | [
"For efficient genetic transformation, Agrobacterium-mediated as well as direct delivery methods have been used successfully. However, these methods suffer from many disadvantages especially in terms of transfer of large genes, gene complexes and gene silencing. To overcome these problems, recently, some efforts ha... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24296066",
"http://www.ncbi.nlm.nih.gov/pubmed/12719540",
"http://www.ncbi.nlm.nih.gov/pubmed/19678910",
"http://www.ncbi.nlm.nih.gov/pubmed/24269346",
"http://www.ncbi.nlm.nih.gov/pubmed/24222505",
"http://www.ncbi.nlm.nih.gov/pubmed/18988631",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A0086451",
"o": "U002966"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0025991",
"o": "http://linkedlifedata.com/resourc... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053672",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002477",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009292",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field... |
515df5b2298dcd4e5100002c | yesno | Are there clinical trials on stem cells in multiple sclerosis | [
"Yes. Human multipotent mesenchymal stem cell (MSC) therapies are currently being tested in clinical trials for multiple sclerosis. Several small pilot clinical trials in subjects with advanced MS have demonstrated that MSC administration is safe and provided an early signal of clinical effectiveness. The current ... | [
"yes"
] | [
"Cells are generally given intravenously. Multiple sclerosis, rheumatoid arthritis and lupus have been successfully treated in human clinical trials",
"Human multipotent mesenchymal stem cell (MSC) therapies are currently being tested in clinical trials for Crohn's disease, multiple sclerosis, graft-versus-host d... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23124791",
"http://www.ncbi.nlm.nih.gov/pubmed/21366911",
"http://www.ncbi.nlm.nih.gov/pubmed/23197667",
"http://www.ncbi.nlm.nih.gov/pubmed/18562508",
"http://www.ncbi.nlm.nih.gov/pubmed/12376881",
"http://www.ncbi.nlm.nih.gov/pubmed/22561409",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013234",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009103",
"http://www.disease-ontology.org/api/metadata/DOID:2377",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Ex... |
54edf81f94afd61504000014 | factoid | Which SWI/SNF protein complex subunit has been demonstrated to interact with the FANCA gene product? | [
"The Fanconi anemia protein FANCA has been shown to interact with the brm-related gene 1 (BRG1) product. BRG1 is a subunit of the SWI/SNF complex, which remodels chromatin structure through a DNA-dependent ATPase activity.",
"FANCA was demonstrated to associate with the endogenous SWI/SNF complexFANCA may recruit... | [
"BRG1"
] | [
"Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex",
"We identified an interaction between the FA protein, FANCA and brm-related gene 1 (BRG1) product. BRG1 is a subunit of the SWI/SNF complex, which remodels chromatin structure through a DNA-dependent ATPase activity",... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11726552"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D052217"
] |
56c6f6005795f9a73e000009 | yesno | Are piRNAs involved in gene silencing? | [
"Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire. Transcriptional silencing implies a piRNA-mediated formation of repressive chro... | [
"yes"
] | [
"In Drosophila ovaries, the nuclear Piwi protein is required for transcriptional silencing of transposons, though the precise mechanisms by which this occurs are unknown.",
"Here we show that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23465540",
"http://www.ncbi.nlm.nih.gov/pubmed/24288375",
"http://www.ncbi.nlm.nih.gov/pubmed/20080197",
"http://www.ncbi.nlm.nih.gov/pubmed/23132912",
"http://www.ncbi.nlm.nih.gov/pubmed/24178563",
"http://www.ncbi.nlm.nih.gov/pubmed/25842866",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0016458",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020868"
] |
554397f6ed966d112c00000c | list | List representatives of the major fungal hypoxanthine-adenine-guanine transporter families. | [
"AzgA and Fcy21p are prototypes of the two major fungal hypoxanthine-adenine-guanine transporter families."
] | [
"AzgA",
"Fcy21p"
] | [
"Comparative kinetic analysis of AzgA and Fcy21p, prototypes of the two major fungal hypoxanthine-adenine-guanine transporter families",
"We carried out a comparative kinetic analysis of two prototypes of these transporter families. The first was Fcy21p, a herein characterized protein of Candida albicans, and the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/14597637",
"http://www.ncbi.nlm.nih.gov/pubmed/19121308",
"http://www.ncbi.nlm.nih.gov/pubmed/24818808",
"http://www.ncbi.nlm.nih.gov/pubmed/16923723",
"http://www.ncbi.nlm.nih.gov/pubmed/7721763"
] | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035345"
] |
551910d3622b194345000008 | list | Which proteins have been identified as RET ligands? | [
"RET is activated by members of the glial cell line-derived neurotrophic factor (GDNF) family of ligands, which include GDNF, neurturin, artemin, and persephin.",
"The RET proto-oncogene encodes a receptor tyrosine kinase, which is activated by members of the glial cell line-derived neurotrophic factor (GDNF) fam... | [
"GDNF",
"glial cell-line-derived neurotrophic factor",
"ARTN",
"artemin",
"NTN",
"neurturin",
"PSPN",
"persephin"
] | [
"Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease",
"Given the pivotal role of RET in HSCR, the genes encoding their ligands (GDNF, NRTN, ARTN, and PSPN) are also good candidates for the disease.",
"Indeed, the RET ligands persephin and GDN... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10652334",
"http://www.ncbi.nlm.nih.gov/pubmed/15013219",
"http://www.ncbi.nlm.nih.gov/pubmed/10790203",
"http://www.ncbi.nlm.nih.gov/pubmed/11973622",
"http://www.ncbi.nlm.nih.gov/pubmed/9473110",
"http://www.ncbi.nlm.nih.gov/pubmed/9284737",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008024",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051096"
] |
5314b20bdae131f847000005 | list | Which substances are dangerous to g6PD deficient individuals? | [
"Antimalarial drugs (primaquine, pamaquine, chloriquine), fava beans, sulfonamides, some antibiotics( nalidixic acid, nitrofurantoin, isoniazid, dapsone, and furazolidone) and henna"
] | [
"primaquine",
"pamaquine",
"chloroquine",
"fava beans",
"sulfonamides",
"antibiotics",
"henna"
] | [
"The principal clinical manifestation encountered was favism.",
"G6PD deficiency is the most common enzymopathy of red blood cells. The clinical symptoms of favism are jaundice, hematuria and haemolytic anaemia that seem to affect liver and kidney in long term. Thus we evaluate kidney and liver function of favism... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23690191",
"http://www.ncbi.nlm.nih.gov/pubmed/22963789",
"http://www.ncbi.nlm.nih.gov/pubmed/17355169",
"http://www.ncbi.nlm.nih.gov/pubmed/22018328",
"http://www.ncbi.nlm.nih.gov/pubmed/23664599",
"http://www.ncbi.nlm.nih.gov/pubmed/23874116",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A12020866",
"o": "134700"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A12020866",
"o": "FAVISM, SUSCEPTIBILITY TO"... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005955",
"http://www.uniprot.org/uniprot/FGD_BEUC1",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004345",
"http://www.uniprot.org/uniprot/G6PD_BACSU",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=... |
52fb78d82059c6d71c000068 | list | Which mutations of SCN5A gene are implicated in Brugada syndrome? | [
"The following mutations of SCN5A gene have been linked to Brugada syndrome:I137M, p.W1095X; c.3284G>A, R27H, E901K, G1743R, V728I, N1443S, E1152X, c.664C>T; p.Arg222X, Ala2>Thr, Ala735, Ala735>Thr, Val1340>Ile, IVS18-1G>A, E1784K (14x), F861WfsX90 (11x), D356N (8x), G1408R (7x), G400A, H558R, W822X, Q55X, V95I, A1... | [
"I137M",
"p.W1095X, c.3284G>A",
"R27H",
"E901K",
"G1743R",
"V728I",
"N1443S",
"E1152X",
"c.664C>T; p.Arg222X",
"Ala2>Thr, Ala735",
"Ala735>Thr",
"Val1340>Ile",
"IVS18-1G>A",
"E1784K (14x)",
"F861WfsX90 (11x)",
"D356N (8x)",
"G1408R (7x)",
"G400A",
"H558R",
"W822X",
"Q55X",
... | [
"This was the first study to systematically investigate sodium channel variants in Chinese patients with ARVD; a new SCN5A mutation, I137M, was found. ",
"We describe a family showing the association between Brugada syndrome and epilepsy in which a known mutation in the SCN5A gene (p.W1095X, c.3284G>A) was identi... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20129283",
"http://www.ncbi.nlm.nih.gov/pubmed/22984773",
"http://www.ncbi.nlm.nih.gov/pubmed/21397042",
"http://www.ncbi.nlm.nih.gov/pubmed/18341814",
"http://www.ncbi.nlm.nih.gov/pubmed/15863661",
"http://www.ncbi.nlm.nih.gov/pubmed/22529811",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053840",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062554",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009154",
"http://www.nlm.nih.gov/cgi/mesh/2... |
571f30c40fd6f91b68000002 | summary | What is Sotos syndrome? | [
"Sotos syndrome is a well-known overgrowth syndrome characterized by excessive growth during childhood, macrocephaly, distinctive facial appearance and learning disability",
"Sotos syndrome is a rare genetic disorder with a distinct phenotypic spectrum including excessive growth during childhood, macrocephaly, di... | [] | [
"Sotos syndrome is a well-known overgrowth syndrome characterized by excessive growth during childhood, macrocephaly, distinctive facial appearance and learning disability",
"Sotos syndrome (SoS) is a multiple anomaly, congenital disorder characterized by overgrowth, macrocephaly, distinctive facial features and ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25852445",
"http://www.ncbi.nlm.nih.gov/pubmed/24670087",
"http://www.ncbi.nlm.nih.gov/pubmed/2319581",
"http://www.ncbi.nlm.nih.gov/pubmed/22715272",
"http://www.ncbi.nlm.nih.gov/pubmed/12807965",
"http://www.ncbi.nlm.nih.gov/pubmed/2347353",
"http://www.ncbi.nlm.nih... | [] | [] |
531e01ff267d7dd05300000e | summary | What is the CRAPome database? | [
"The CRAPome is a contaminant repository for affinity purification-mass spectrometry data."
] | [] | [
"the contaminant repository for affinity purification (the CRAPome)"
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/23921808"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019991",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D030562"
] |
535d5bac7d100faa09000001 | list | List all articles on network meta-analysis for smoking cessation | [
"Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis.\nPharmacological interventions for smoking cessation: an overview and network meta-analysis\nEffectiveness and cost-effectiveness of computer and other electronic aids for smoking cessation: a systematic review and ... | [
"Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis.",
"Pharmacological interventions for smoking cessation: an overview and network meta-analysis",
"Effectiveness and cost-effectiveness of computer and other electronic aids for smoking cessation: a systematic rev... | [
"Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis.",
"Pharmacological interventions for smoking cessation: an overview and network meta-analysis.",
"Effectiveness and cost-effectiveness of computer and other electronic aids for smoking cessation: a systematic re... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23728690",
"http://www.ncbi.nlm.nih.gov/pubmed/22992327",
"http://www.ncbi.nlm.nih.gov/pubmed/24323793",
"http://www.ncbi.nlm.nih.gov/pubmed/19357145",
"http://www.ncbi.nlm.nih.gov/pubmed/23046909"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017418",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016540"
] |
56ed08062ac5ed1459000005 | yesno | Can RG7112 inhibit MDM2? | [
"Yes, RG7112 is a small molecule MDM2 antagonist."
] | [
"yes"
] | [
"To assess the influence of the p53 regulatory pathway further, we studied the effect of RG7112, a small molecule MDM2 antagonist that activates p53 by preventing its interaction with MDM2, on normal megakaryocytopoiesis and platelet production.",
"RG7112 (2g) is the first clinical small-molecule MDM2 inhibitor d... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23400593",
"http://www.ncbi.nlm.nih.gov/pubmed/23808545",
"http://www.ncbi.nlm.nih.gov/pubmed/24900694",
"http://www.ncbi.nlm.nih.gov/pubmed/22753001",
"http://www.ncbi.nlm.nih.gov/pubmed/23084521",
"http://www.ncbi.nlm.nih.gov/pubmed/24869939",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/MDM2_DANRE",
"http://www.uniprot.org/uniprot/MDM2_MOUSE",
"http://www.uniprot.org/uniprot/MDM2_MESAU",
"http://www.uniprot.org/uniprot/MDM2_CANLF",
"http://www.uniprot.org/uniprot/MDM2_HUMAN",
"http://www.uniprot.org/uniprot/MDM2_FELCA",
"http://www.uniprot.org/uniprot/MD... |
55200c606b348bb82c000013 | factoid | Which clotting factor is inhibited by betrixaban? | [
"Betrixaban is an orally administered direct clotting factor Xa inhibitor."
] | [
"Xa"
] | [
"Evaluation of the oral direct factor Xa inhibitor - betrixaban.",
"Betrixaban , an orally administered direct factor Xa inhibitor, is entering a Phase III trial and undergoing investigation for similar indications as apixaban, dabigatran and rivaroxaban. ",
"Following the success of the direct thrombin and FXa... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23876036",
"http://www.ncbi.nlm.nih.gov/pubmed/21144965",
"http://www.ncbi.nlm.nih.gov/pubmed/23298923",
"http://www.ncbi.nlm.nih.gov/pubmed/22371104",
"http://www.ncbi.nlm.nih.gov/pubmed/19132191",
"http://www.ncbi.nlm.nih.gov/pubmed/23964817",
"http://www.ncbi.nlm.n... | [] | [] |
55031270e9bde6963400001a | list | Which are the most frequent syndromes associated with inherited bone marrow failure? | [
"The inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of genetic disorders that share the inability of the bone marrow to produce an adequate number of blood cells. The 4 most frequent syndromes are Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond-Blackfan anemia (DBA), and Shwachm... | [
"Fanconi anemia",
"Dyskeratosis congenita",
"Diamond-Blackfan anemia",
"Shwachman-Diamond syndrome"
] | [
"Ocular and orbital manifestations of the inherited bone marrow failure syndromes: Fanconi anemia and dyskeratosis congenita",
"The inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of genetic disorders that share the inability of the bone marrow to produce an adequate number of blood cell... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16304365",
"http://www.ncbi.nlm.nih.gov/pubmed/20022637"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001853",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001855",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019046",
"http://www.disease-ontology.org/a... |
533aaab6d6d3ac6a34000062 | summary | How is yellow fever virus transmitted? | [
"Yellow fever virus is transmitted by mosquitoes and is restricted to Africa, Central and South America and the Caribbean. \nYellow fever virus is a flavivirus, and there is only one antigenic type. It was taken to the Americas by the early slave traders, and nowadays reported in Africa, America, Asia and Europe. Y... | [] | [
"Yellow Fever (YF) is an acute viral communicable disease transmitted by an arbovirus of the flavivirus genus. It is primarily a zoonotic disease, especially the monkeys. Worldwide, an estimated 200 000 cases of yellow fever occurred each year, and the case-fatality rate is ~15%. Forty-five endemic countries in Afr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20513550",
"http://www.ncbi.nlm.nih.gov/pubmed/23697028",
"http://www.ncbi.nlm.nih.gov/pubmed/21143108",
"http://www.ncbi.nlm.nih.gov/pubmed/23411863",
"http://www.ncbi.nlm.nih.gov/pubmed/21413253",
"http://www.ncbi.nlm.nih.gov/pubmed/24056028",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015004",
"http://www.disease-ontology.org/api/metadata/DOID:9682",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015005"
] |
532f08dcd6d3ac6a3400002a | yesno | Are there any specific antidotes for dabigatran? | [
"No specific antidote currently exists for dabigatran"
] | [
"no"
] | [
"Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOA... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22615265",
"http://www.ncbi.nlm.nih.gov/pubmed/23389753",
"http://www.ncbi.nlm.nih.gov/pubmed/23312927",
"http://www.ncbi.nlm.nih.gov/pubmed/23460104",
"http://www.ncbi.nlm.nih.gov/pubmed/23657589",
"http://www.ncbi.nlm.nih.gov/pubmed/22669799",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000931",
"http://www.biosemantics.org/jochem#4242811"
] |
56a8b8b5a17756b72f000005 | factoid | What is the outcome of TAF10 interacting with the GATA1 transcription factor? | [
"TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis."
] | [
"Control of Mouse Erythropoiesis"
] | [
"TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.",
"we show that TAF10 interacts directly with GATA1 and that TAF10 is enriched on the GATA1 locus in human fetal erythroid cells",
"TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis"
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/25870109"
] | [] | [
"http://www.uniprot.org/uniprot/GATA1_HUMAN",
"http://www.uniprot.org/uniprot/TAF10_HUMAN",
"http://www.uniprot.org/uniprot/GAT1A_XENLA",
"http://www.uniprot.org/uniprot/GATA1_ARATH",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D050982",
"http://www.uniprot.org/unipro... |
516d5bc5298dcd4e51000079 | summary | How does TNF affect thyroid hormone receptors? | [
"TNF-alpha inhibits the T3-induced expression of thyroid hormone receptor-beta"
] | [] | [
"treatment of the cells with T(3) for 2 d induced the expression of thyroid hormone receptor-beta and caspase-3, and this thyroid hormone receptor-beta induction was drastically repressed by xTNF-alpha."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/18403482"
] | [] | [
"http://www.uniprot.org/uniprot/THA_LITCT",
"http://www.uniprot.org/uniprot/THB_SHEEP",
"http://www.uniprot.org/uniprot/THA_MOUSE",
"http://www.uniprot.org/uniprot/THAA_PAROL",
"http://www.uniprot.org/uniprot/THA_PYGAD",
"http://www.uniprot.org/uniprot/THA_CHICK",
"http://www.uniprot.org/uniprot/THA_APT... |
56d2ac03f22319765a000004 | list | Which ones are the ESKAPE organisms? | [
"The 6 ESKAPE pathogens are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species."
] | [
"Enterococcus faecium",
"Staphylococcus aureus",
"Klebsiella pneumoniae",
"Acinetobacter baumannii",
"Pseudomonas aeruginosa",
"Enterobacter species"
] | [
"The aim of this study was to test in the clinic whether antimicrobial diversity affects resistance of Enterococcus faecium, Staphylococcus aureus, Klebsiella species, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE) pathogens in ventilator-associated pneumonia (VAP).",
"Despite ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22366995",
"http://www.ncbi.nlm.nih.gov/pubmed/25124187",
"http://www.ncbi.nlm.nih.gov/pubmed/24342634",
"http://www.ncbi.nlm.nih.gov/pubmed/26139286",
"http://www.ncbi.nlm.nih.gov/pubmed/21659436",
"http://www.ncbi.nlm.nih.gov/pubmed/23548324",
"http://www.ncbi.nlm.n... | [] | [] |
56d046813975bb303a00000f | summary | What is the effect of dovitinib on the cell cycle? | [
"Dovitinib triggers a G2 /M arrest. It promotes a delay in mitotic exit in a subset of cells, causing the cells to undergo mitotic slippage. Higher concentrations of Dovitinib induce a G2 arrest similar to the G2 DNA damage checkpoint."
] | [] | [
"Dovitinib triggered a G2 /M arrest in cancer cell lines from diverse origins including HeLa, nasopharyngeal carcinoma, and hepatocellular carcinoma. Single-cell analysis revealed that Dovitinib promoted a delay in mitotic exit in a subset of cells, causing the cells to undergo mitotic slippage. Higher concentratio... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22027573",
"http://www.ncbi.nlm.nih.gov/pubmed/21521775",
"http://www.ncbi.nlm.nih.gov/pubmed/24238094"
] | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0007050"
] |
55391b2cbc4f83e828000017 | summary | What is the involvement of PDGFRB in metastatic medulloblastoma? | [
"Platelet-derived growth factor (PDGF) receptor B (PDGFRB) expression was shown to correlate with metastatic medulloblastoma, while PDGFRB tyrosine kinase activity was demonstrated to be critical for migration and invasion of medulloblastoma cells possibly by transactivating EGFR."
] | [] | [
"Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of epidermal growth factor receptor",
"Platelet-derived growth factor (PDGF) receptor (PDGFR) expression correlates with metastatic medulloblastoma.... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19417143"
] | [] | [
"http://www.uniprot.org/uniprot/PGFRB_TAKRU",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020797",
"http://www.disease-ontology.org/api/metadata/DOID:3858"
] |
54dc8ed6c0bb8dce23000002 | summary | What is known as Calcium Induced Calcium Release (CICR) and its role in cardiomyocyte contractility? | [
"the cicr mechanism has been understood mainly based on binding of cytosolic ca(2+) with ryanodine receptors (ryrs) and inducing ca(2+) release from the sarcoplasmic reticulum (sr). l-type ca(2+) channels activate ryrs to produce cicr in smooth muscle cells in the form of ca(2+) sparks and propagated ca(2+) waves. ... | [] | [
"Cardiomyocyte contraction depends on rapid changes in intracellular Ca(2+). In mammals, Ca(2+) influx as L-type Ca(2+) current (ICa) triggers the release of Ca(2+) from sarcoplasmic reticulum (SR) and Ca(2+)-induced Ca(2+) release (CICR) is critical for excitation-contraction coupling.",
"Release of calcium (Ca(... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23123322",
"http://www.ncbi.nlm.nih.gov/pubmed/2726431",
"http://www.ncbi.nlm.nih.gov/pubmed/21718716",
"http://www.ncbi.nlm.nih.gov/pubmed/18538346",
"http://www.ncbi.nlm.nih.gov/pubmed/25377479",
"http://www.ncbi.nlm.nih.gov/pubmed/21979103",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.biosemantics.org/jochem#4277675"
] |
52bf1f5f03868f1b06000017 | summary | What is the action of molindone? | [
"Molindone is a short-acting antipsychotic.\nMolindone, along with other antipsychotic drugs which elicit little or no Parkinsonism, bind more loosely than dopamine to D2 receptors. Compared to the tightly bound antipsychotic drugs, the more loosely bound antipsychotics generally require higher clinical doses, requ... | [] | [
"As determined by the new dissociation constants, antipsychotic drugs which elicit Parkinsonism (trifluperazine, chlorpromazine, raclopride, haloperidol, fluphenazine, risperidone) bind more tightly than dopamine to D2, while those antipsychotic drugs which elicit little or no Parkinsonism (melperone, seroquel, per... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7656507",
"http://www.ncbi.nlm.nih.gov/pubmed/9353417",
"http://www.ncbi.nlm.nih.gov/pubmed/9577836",
"http://www.ncbi.nlm.nih.gov/pubmed/6249092",
"http://www.ncbi.nlm.nih.gov/pubmed/1224004",
"http://www.ncbi.nlm.nih.gov/pubmed/6817377",
"http://www.ncbi.nlm.nih.gov... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A17796303",
"o": "T43.505"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A17796303",
"o": "Adverse effect of unspeci... | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493",
"http://www.biosemantics.org/jochem#4066301",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004364",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008972",
"h... |
5518e7a7622b194345000002 | summary | What is the function of the enzymes known as dual specificity phoshpatases (DUSPs)? | [
"DUSPs (dual-specificity phosphatases) are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. DUSPs have been implicated as major modulators of critical signalling pathways that are dysregulated in various... | [] | [
"MAPK activity is negatively regulated by members of the dual specificity phosphatase (Dusp) family, which differ in expression, substrate specificity, and subcellular localization.",
"Dual-specificity phosphatases (DUSPs) dephosphorylate phosphotyrosine and phosphoserine/phosphothreonine residues on target MAPKs... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22812510",
"http://www.ncbi.nlm.nih.gov/pubmed/24155099",
"http://www.ncbi.nlm.nih.gov/pubmed/21300429",
"http://www.ncbi.nlm.nih.gov/pubmed/21288197",
"http://www.ncbi.nlm.nih.gov/pubmed/22266315",
"http://www.ncbi.nlm.nih.gov/pubmed/24311790",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054638",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054637",
"http://www.uniprot.org/uniprot/PTP3_CHLMO",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008138",
"ht... |
5324bdba9b2d7acc7e00001a | factoid | How is bladder wall thickness measured? | [
"Ultrasound"
] | [
"Ultrasound"
] | [
"Modifications of the bladder wall (organ damage) in patients with bladder outlet obstruction: ultrasound parameters.",
"Early identification of bladder changes by noninvasive transabdominal ultrasound",
"Measurement of the bladder wall thickness (BWT) or detrusor wall thickness (DWT) by US is reliable,",
"Al... | [
"http://www.ncbi.nlm.nih.gov/pubmed/14511039",
"http://www.ncbi.nlm.nih.gov/pubmed/17445666",
"http://www.ncbi.nlm.nih.gov/pubmed/20432327",
"http://www.ncbi.nlm.nih.gov/pubmed/20438565",
"http://www.ncbi.nlm.nih.gov/pubmed/19238399",
"http://www.ncbi.nlm.nih.gov/pubmed/23427760",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001743"
] |
54f35ad864850a5854000004 | factoid | LY450139 is investigational name of which drug? | [
"LY450139 is investigational name of Semagacestat. It is a γ-secretase inhibitor developed for treatment for Alzheimer's disease. Chemical name of LY450139 is hydroxylvaleryl monobenzocaprolactam."
] | [
"semagacestat"
] | [
"The outcomes of the clinical trials of the γ-secretase inhibitor Semagacestat (LY-450139) and the γ-secretase modulator (GSM) Tarenflurbil were disappointing, but may not represent the end of the γ-secretase era. ",
"A selective BACE inhibitor and the γ-secretase inhibitor LY450139 (semagacestat) were used to in... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19692615",
"http://www.ncbi.nlm.nih.gov/pubmed/20350302",
"http://www.ncbi.nlm.nih.gov/pubmed/22710916",
"http://www.ncbi.nlm.nih.gov/pubmed/22018341",
"http://www.ncbi.nlm.nih.gov/pubmed/23278303",
"http://www.ncbi.nlm.nih.gov/pubmed/19527190",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015507"
] |
54fefbbc6ad7dcbc1200000a | yesno | Are there any Decision support systems for chronic pain management ? | [
"Yes, there is a variety of decision support systems for chronic pain management.",
"Clinical decision support systems are promising tools for improving behavioral medicine care for chronic pain.The use of a computer-based decision support system facilitates primary care physicians' management of chronic pain."
] | [
"yes"
] | [
"a project to operationalize the 2003 VA/DOD Clinical Practice Guideline for Opioid Therapy for Chronic Non-Cancer Pain into a computerized decision support system (DSS)",
"We based the DSS on the existing ATHENA-DSS",
"Use of this iterative process led to development of a multifunctional DSS",
"interactive d... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21249951",
"http://www.ncbi.nlm.nih.gov/pubmed/20385018",
"http://www.ncbi.nlm.nih.gov/pubmed/24073031",
"http://www.ncbi.nlm.nih.gov/pubmed/23601912",
"http://www.ncbi.nlm.nih.gov/pubmed/11524346"
] | [] | [] |
5727ab040fd6f91b68000019 | factoid | Which gene has been found to be mutant in Lesch-Nyhan Disease patients? | [
"Lesch-Nyhan Disease (LND) is the result of mutations in the X-linked gene encoding the purine metabolic enzyme, hypoxanthine guanine phosphoribosyl transferase (HPRT)."
] | [
"Hypoxanthine guanine phosphoribosyl transferase (HPRT) gene"
] | [
"We describe a family of seven boys affected by Lesch-Nyhan disease with various phenotypes. Further investigations revealed a mutation c.203T>C in the gene encoding HGprt of all members, with substitution of leucine to proline at residue 68 (p.Leu68Pro)",
"Lesch-Nyhan disease (LND) is caused by deficiency of hyp... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8485579",
"http://www.ncbi.nlm.nih.gov/pubmed/22132985",
"http://www.ncbi.nlm.nih.gov/pubmed/22042773",
"http://www.ncbi.nlm.nih.gov/pubmed/15571229",
"http://www.ncbi.nlm.nih.gov/pubmed/23691025",
"http://www.ncbi.nlm.nih.gov/pubmed/20159777",
"http://www.ncbi.nlm.ni... | [] | [] |
516e7fda298dcd4e51000081 | factoid | Which is the methyl donor of histone methyltransferases? | [
"The major methyl donor of histone methyltransferases (HMTs) is S-adenosyl-L–methionine (SAM, AdoMet)."
] | [
"S-adenosyl-L–methionine",
"SAM",
"AdoMet",
"S-Adenosylmethionine",
"adenosylmethionine",
"S-Adenosyl methionine"
] | [
"While SAMe is a methyl donor, MTA is an inhibitor of methylation. SAMe can convert to MTA spontaneously, so the effect of exogenous SAMe may be mediated by MTA.",
"Based on known SET domain structures, the mutations likely affect either the lysine-substrate binding pocket, the binding site for the adenosylmethio... | [
"http://www.ncbi.nlm.nih.gov/pubmed/2461933",
"http://www.ncbi.nlm.nih.gov/pubmed/12819771",
"http://www.ncbi.nlm.nih.gov/pubmed/22561085",
"http://www.ncbi.nlm.nih.gov/pubmed/23086207",
"http://www.ncbi.nlm.nih.gov/pubmed/20936105",
"http://www.ncbi.nlm.nih.gov/pubmed/18693240",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://purl.uniprot.org/core/ecName",
"s": "http://linkedlifedata.com/resource/#_413252395935006",
"o": "2.1.1.-"
}
] | [
"http://www.uniprot.org/uniprot/DOT1_CANGA",
"http://www.uniprot.org/uniprot/CLR4_SCHPO",
"http://www.uniprot.org/uniprot/DOT1_ASPFU",
"http://www.uniprot.org/uniprot/DOT1_CRYNJ",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0031060",
"http://www.uniprot.org/uniprot/SET1_DICDI",
"http:... |
51603912298dcd4e5100003b | summary | How are human accelerated regions (HAR) defined? | [
"Human accelerated regions (HAR) are defined as previously slowly evolving regions of the genome that have evolved most quickly along the human lineage. These represent genomic regions that are conserved among vertebrates but have accumulated substitutions on the human lineage at an accelerated rate."
] | [] | [
"regions in the human genome that show significant evolutionary acceleration",
"This identified Human Accelerated Region 1 (HAR1), a rapidly-evolving cis-antisense locus that is specifically transcribed in the nervous system",
"We devised a ranking of regions in the human genome that show significant evolutiona... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20502635",
"http://www.ncbi.nlm.nih.gov/pubmed/20179156",
"http://www.ncbi.nlm.nih.gov/pubmed/16915236",
"http://www.ncbi.nlm.nih.gov/pubmed/22075116",
"http://www.ncbi.nlm.nih.gov/pubmed/22412940"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012045"
] |
515870cdd24251bc0500008f | list | Carbapenemase-producing gram-negative bacteria is a major health concern because their resistance to antibiotics.
List the most frequent carbapenemases found in Enterobacteriaceae. | [
"The most frequent carbapenemases in Enterobacteriaceae are OXA-48, KPC, VIM, NDM, IMP, SME, NMC, GES, IMI and MBL."
] | [
"OXA-48",
"KPC",
"VIM",
"NDM",
"IMP",
"SME",
"NMC",
"GES",
"IMI",
"MBL"
] | [
"The most frequent carbapenemases in Enterobacteriaceae were OXA-48, KPC and VIM-1; in P. aeruginosa it was VIM-2 and in A. baumannii OXA-23.",
"bla(IMP), bla(VIM), bla(SPM), bla(SIM) and bla(GIM), and of bla(KPC), bla(NDM) and bla(OXA-",
"Detection of NDM-1, VIM-1, KPC, OXA-48, and OXA-162 carbapenemases by ma... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20534805",
"http://www.ncbi.nlm.nih.gov/pubmed/23114438",
"http://www.ncbi.nlm.nih.gov/pubmed/22553235",
"http://www.ncbi.nlm.nih.gov/pubmed/20237104",
"http://www.ncbi.nlm.nih.gov/pubmed/22796889",
"http://www.ncbi.nlm.nih.gov/pubmed/20960935",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/pubmed/mesh/Enterobacteriaceae",
"o": "Enterobacteriaceae"
}
] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004352",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000903",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004756",
"http://amigo.geneontology.org/cgi... |
56eaf4e6107309bc2f000001 | summary | How are GRBs (Genomic Regulatory Blocks) defined? | [
"Genomic regulatory blocks (GRBs) are chromosomal regions spanned by highly conserved non-coding elements (HCNEs), most of which serve as regulatory inputs of one target gene in the region. The target genes are most often transcription factors involved in embryonic development and differentiation. GRBs often contai... | [] | [
"Reporter insertions distal to zebrafish developmental regulatory genes pax6.1/2, rx3, id1, and fgf8 and miRNA genes mirn9-1 and mirn9-5 recapitulate the expression patterns of these genes even if located inside or beyond bystander genes, suggesting that the regulatory domain of a developmental regulatory gene can ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19561171",
"http://www.ncbi.nlm.nih.gov/pubmed/22962458",
"http://www.ncbi.nlm.nih.gov/pubmed/21619633",
"http://www.ncbi.nlm.nih.gov/pubmed/20080751",
"http://www.ncbi.nlm.nih.gov/pubmed/22234889",
"http://www.ncbi.nlm.nih.gov/pubmed/18047696",
"http://www.ncbi.nlm.n... | [] | [] |
5171438a8ed59a060a000007 | factoid | What is the gene frequently mutated in Multiple endocrine neoplasia 2 (MEN2) and Hisrchsprung disease? | [
"The Ret gene may have gain of mutation functions in MEN2 cancer as well as loss of function mutations in Hirschprung disease."
] | [
"Ret"
] | [
"Our results further substantiate that gene scanning of all relevant RET exons is a powerful tool in the management of MEN2 patients,",
"We identified RET mutations in seven of 13 MTCs: five RET-positive cases revealed a mutation in exon 16 (M918T) and two a mutation in exon 10 (C618S and C620S). In four of the R... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18062802",
"http://www.ncbi.nlm.nih.gov/pubmed/17525482",
"http://www.ncbi.nlm.nih.gov/pubmed/23210566",
"http://www.ncbi.nlm.nih.gov/pubmed/21542403",
"http://www.ncbi.nlm.nih.gov/pubmed/9745455",
"http://www.ncbi.nlm.nih.gov/pubmed/16712668",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018813",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006627"
] |
52f4f1d62059c6d71c00001c | list | Which are the clinical characteristics of isolated Non-compaction cardiomyopathy? | [
"The clinical characteristics of isolated Non-compaction cardiomyopathy are excessively thickened endocardial layer with deep intertrabecular recesses (with ratio of non-compacted to compacted myocardium >2), heart failure, syncope, ventricular arrhythmias, stroke, pulmonary hypertension, complete left branch condu... | [
"excessively thickened endocardial layer with deep intertrabecular recesses",
"ratio of non-compacted to compacted myocardium >2",
"heart failure",
"syncope",
"ventricular arrhythmias",
"stroke",
"Pulmonary hypertension",
"complete left branch conductive block",
"sick sinus syndrome",
"paroxysmal ... | [
"Non compaction cardiomyopathy is a rare disorder caused by the arrest of myocardial compaction during embryogenesis, leading to a non compacted endocardial layer with marked hypertrabeculation and deep recesses.",
"The form of presentation was heart failure in 53% of subjects, syncope in 20%o, ventricular arrhyt... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18700964",
"http://www.ncbi.nlm.nih.gov/pubmed/17174235",
"http://www.ncbi.nlm.nih.gov/pubmed/19664240",
"http://www.ncbi.nlm.nih.gov/pubmed/21246178",
"http://www.ncbi.nlm.nih.gov/pubmed/21193437",
"http://www.ncbi.nlm.nih.gov/pubmed/16170691",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011154",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056830"
] |
56b8ccc5156496395c000003 | summary | What is STARR-seq? | [
"STARR-seq is a method to directly and quantitatively assess enhancer activity for millions of candidates from arbitrary sources of DNA, which enables screens across entire genomes. When applied to the Drosophila genome, STARR-seq identifies thousands of cell type-specific enhancers across a broad continuum of stre... | [] | [
"We developed a method termed STARR-seq to directly and quantitatively assess enhancer activity for millions of candidates from arbitrary sources of DNA, which enables screens across entire genomes. When applied to the Drosophila genome, STARR-seq identifies thousands of cell type-specific enhancers across a broad ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23328393",
"http://www.ncbi.nlm.nih.gov/pubmed/24685159"
] | [] | [] |
533c384dc45e133714000006 | list | In which genomic positions is the histone variant macroH2A enriched? | [
"macroH2A1 is enriched on the inactive X chromosome in female mammalian cells, where it functions to maintain gene silencing. The transcribed regions of most active genes are depleted of macroH2A, often in sharply localized domains that show depletion of 4-fold or more relative to bulk mouse liver chromatin. This r... | [
"Repressed regions",
"Inactive X chromosome",
"Centromeres"
] | [
"Although macroH2A1 nucleosomes are widely distributed across the genome, their local concentration varies over a range of 100-fold or more",
"The transcribed regions of most active genes are depleted of macroH2A1, often in sharply localized domains that show depletion of 4-fold or more relative to bulk mouse liv... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16738309",
"http://www.ncbi.nlm.nih.gov/pubmed/16213499",
"http://www.ncbi.nlm.nih.gov/pubmed/20670405",
"http://www.ncbi.nlm.nih.gov/pubmed/14608463",
"http://www.ncbi.nlm.nih.gov/pubmed/20937776",
"http://www.ncbi.nlm.nih.gov/pubmed/12082075",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006657",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016678",
"http://www.biosemantics.org/jochem#4278518",
"http://www.uniprot.org/uniprot/H2AW_MOUSE"
] |
516d5baa298dcd4e51000078 | yesno | Does amiodarone affect thyroid hormone receptors in the myocardium? | [
"Yes"
] | [
"yes"
] | [
"AM and Dron affected TR expression in the RA similarly by decreasing TRalpha 1 and beta 1 expression by about 50%",
"In the LVW, AM and Dron decreased TRbeta 1 and, interestingly, AM increased TRalpha 1.",
"n the apex, AM also increased TRalpha 2.",
"Both in treated and untreated mice, TRalpha2 mRNA had the ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10445678",
"http://www.ncbi.nlm.nih.gov/pubmed/9781936",
"http://www.ncbi.nlm.nih.gov/pubmed/7598731",
"http://www.ncbi.nlm.nih.gov/pubmed/17535870"
] | [] | [
"http://www.uniprot.org/uniprot/THA_LITCT",
"http://www.uniprot.org/uniprot/THB_HUMAN",
"http://www.uniprot.org/uniprot/THB_SHEEP",
"http://www.uniprot.org/uniprot/THA_MOUSE",
"http://www.uniprot.org/uniprot/THA_PYGAD",
"http://www.uniprot.org/uniprot/THA_CHICK",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB... |
56ffd08bcf1c325851000009 | factoid | From which sequence does the Alu repeat originate from? | [
"The presence of Alu-like structural motifs supports the hypothesis of the monophyletic origin of Alu and B1 repeats, i.e., from a common 7SL RNA-derived retroposing monomeric element, The origin of Alu subfamilies in human populations may be related to evolution of chromosome Y."
] | [
"7SL RNA"
] | [
"The origin of Alu-derived minisatellites appears to have been mediated by short flanking repeats, as first proposed by Haber and Louis",
"Finally, we propose that the origin of Alu subfamilies in human populations may be related to evolution of chromosome Y.",
"Our analysis indicates that about 60 Myr ago, bef... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9694666",
"http://www.ncbi.nlm.nih.gov/pubmed/8576966",
"http://www.ncbi.nlm.nih.gov/pubmed/16343813",
"http://www.ncbi.nlm.nih.gov/pubmed/12815945",
"http://www.ncbi.nlm.nih.gov/pubmed/12167372",
"http://www.ncbi.nlm.nih.gov/pubmed/9395063"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020087"
] |
5313058de3eabad02100000e | factoid | Abnormality in which vertebral region is important in the Bertolotti's syndrome? | [
"Lumbosacral vertebral region is implicated in the Bertolotti's syndrome. Lumbosacral transitional vertebra is an anatomical variation of the fifth lumbar vertebra in which an enlarged transverse process can form a joint or fusion with the sacrum or ilium. Patients often complain of intractable sciatica that arises... | [
"lumbosacral"
] | [
"Bertolotti's syndrome (BS), a form of lumbago in lumbosacral transitional vertebrae, is an important cause of low back pain in young patients. ",
" Common causes of back pain were the ipsilateral L5-S1 facet joint, neoarticulation, the SI joint, and disc degeneration. ",
"Patients with Bertolotti's syndrome ha... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11154546",
"http://www.ncbi.nlm.nih.gov/pubmed/23969004",
"http://www.ncbi.nlm.nih.gov/pubmed/2533403",
"http://www.ncbi.nlm.nih.gov/pubmed/16943469",
"http://www.ncbi.nlm.nih.gov/pubmed/18596536",
"http://www.ncbi.nlm.nih.gov/pubmed/8457417",
"http://www.ncbi.nlm.nih... | [
{
"p": "http://linkedlifedata.com/resource/pubmed/keyword",
"s": "http://linkedlifedata.com/resource/pubmed/id/13767955",
"o": "http://linkedlifedata.com/resource/pubmed/keyword/LUMBOSACRAL+REGION%2Fabnormalities"
},
{
"p": "http://linkedlifedata.com/resource/pubmed/keyword",
"s": "http://li... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013131",
"http://www.disease-ontology.org/api/metadata/DOID:225",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577"
] |
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