id stringlengths 24 24 | type stringclasses 4
values | body stringlengths 13 215 | ideal_answer listlengths 1 12 | exact_answer listlengths 0 44 | snippets listlengths 0 121 | documents listlengths 1 157 | triples listlengths 0 537 | concepts listlengths 0 99 |
|---|---|---|---|---|---|---|---|---|
51475d5cd24251bc0500001b | list | Where is X-ray free electron laser used? | [
"X-ray free electron laser (XFEL) technologies provide coherent and extremely intense photon pulses of short duration. XFELs are particularly useful in structural biology and imaging, in structural studies of single biological macromolecules (e.g. high resolution protein structure determination) and assemblies (e.g... | [
"high resolution protein structure determination",
"molecular imaging",
"single-particle imaging",
"study of enzyme kinetics",
"time resolved protein crystallography"
] | [
"In conjunction with the XFEL temporal profile and high-flux, it is a powerful tool for studying the dynamics of time-dependent systems. Photo-induced processes and fast catalytic reaction kinetics, ranging from femtoseconds to milliseconds, will be resolvable in a wide array of systems circumventing radiation dama... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23331310",
"http://www.ncbi.nlm.nih.gov/pubmed/21293374",
"http://www.ncbi.nlm.nih.gov/pubmed/21293373",
"http://www.ncbi.nlm.nih.gov/pubmed/22575364",
"http://www.ncbi.nlm.nih.gov/pubmed/22975810",
"http://www.ncbi.nlm.nih.gov/pubmed/22893239",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056928",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018360",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004583",
"http://www.nlm.nih.gov/cgi/mesh/2... |
54db7c4ac0bb8dce23000001 | list | Which protein kinases have been found to phosphorylate Phospholamban and affect its biological activity? | [
"Phosphorylation of phospholamban at Ser16 is mainly mediated by PKA and at Thr17 by Ca(2+) /calmodulin-dependent protein kinase (CaMKII). Phospholamban is also a reporter for PKG activity and akt kinase interacts with and phosphorylates PLN at Thr(17)."
] | [
"protein kinase A",
"PKA",
"protein kinase G",
"PKG",
"Ca(2+) /calmodulin-dependent protein kinase II",
"CaMKII",
"akt kinase",
"Akt"
] | [
"Dephosphorylated PLN is an inhibitor of SERCA2a and phosphorylation by protein kinase A (PKA) or calcium-calmodulin-dependent protein kinases (CAMKII) relieves these inhibitory effects. ",
"We have found that phosphorylation of PLN by protein kinase A (PKA) leads to an increase in the rate of Ca(2+) leak from Ca... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22463608",
"http://www.ncbi.nlm.nih.gov/pubmed/22707725",
"http://www.ncbi.nlm.nih.gov/pubmed/19696029",
"http://www.ncbi.nlm.nih.gov/pubmed/20060004",
"http://www.ncbi.nlm.nih.gov/pubmed/20349314",
"http://www.ncbi.nlm.nih.gov/pubmed/22772476",
"http://www.ncbi.nlm.n... | [] | [] |
57152ebbcb4ef8864c000002 | summary | Why can't humans synthesize Neu5Gc (N-Glycolylneuraminic acid)? | [
"N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. Humans lack a functional cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) protein and cannot synthesize the sugar Neu5Gc, an innate mammalian signal of self. Losing this sugar changed how humans... | [] | [
"Human muscle from normal (no evident disease, n = 3), Becker (BMD, n = 3) and Duchenne (DMD, n = 3) muscular dystrophy individuals had absent to very low Neu5Gc staining, but some punctate intracellular muscle staining was present in BMD and DMD muscles",
"N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synt... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25003133",
"http://www.ncbi.nlm.nih.gov/pubmed/25124893",
"http://www.ncbi.nlm.nih.gov/pubmed/18669916",
"http://www.ncbi.nlm.nih.gov/pubmed/24505439",
"http://www.ncbi.nlm.nih.gov/pubmed/23520510",
"http://www.ncbi.nlm.nih.gov/pubmed/16806174",
"http://www.ncbi.nlm.n... | [] | [] |
54e0c3e71388e8454a000013 | factoid | Which enzyme is inhibited by Orteronel? | [
"Orteronel inhibits the 17,20 lyase activity of the enzyme CYP17A1, which is important for androgen synthesis in the testes, adrenal glands and prostate cancer cells. Orteronel is used for treatment for castration-resistant prostate cancer."
] | [
"CYP17A1"
] | [
"PURPOSE: Orteronel (TAK-700) is a non-steroidal, selective, reversible inhibitor of 17,20-lyase.",
"The drug orteronel selectively blocked the lyase reaction of P450 17A1 but only in the case of Prog. ",
"Preclinical assessment of Orteronel(®), a CYP17A1 enzyme inhibitor in rats.",
"Orteronel (TAK-700) is a ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25533464",
"http://www.ncbi.nlm.nih.gov/pubmed/24759590",
"http://www.ncbi.nlm.nih.gov/pubmed/24799061",
"http://www.ncbi.nlm.nih.gov/pubmed/23856460",
"http://www.ncbi.nlm.nih.gov/pubmed/24418642",
"http://www.ncbi.nlm.nih.gov/pubmed/24965748",
"http://www.ncbi.nlm.n... | [] | [] |
54db5e24bcba1b1817000002 | factoid | What is the disorder in which mutations in U4atac snRNA are detected? | [
"Mutations in U4atac snRNA are thought to be the cause of Microcephalic Osteodysplastic Primordial Dwarfism type I (MOPDI), a recessive form of developmental disorder.",
"Biallelic mutations of the human RNU4ATAC gene, which codes for the minor spliceosomal U4atac snRNA, cause the developmental disorder, MOPD I/T... | [
"Microcephalic osteodysplastic primordial dwarfism type I (MOPDI)"
] | [
"Biallelic mutations of the human RNU4ATAC gene, which codes for the minor spliceosomal U4atac snRNA, cause the developmental disorder, MOPD I/TALS",
"To date, nine separate mutations in RNU4ATAC have been identified in MOPD I patients.",
"In this report, we establish a mechanistic basis for MOPD I disease and ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21815888",
"http://www.ncbi.nlm.nih.gov/pubmed/24865609",
"http://www.ncbi.nlm.nih.gov/pubmed/21990275",
"http://www.ncbi.nlm.nih.gov/pubmed/21474760",
"http://www.ncbi.nlm.nih.gov/pubmed/21474761"
] | [] | [] |
515d692c298dcd4e5100000a | factoid | Which is the binding site motif of Sp1? | [
"Sp1 binds to a GC-rich sequence element containing the decanucleotide consensus sequence 5′-(G/T)GGGCGG(G/A)(G/A)(C/T)-3′ (GC box element) in double stranded DNA (dsDNA). Gel shift competition studies and DNase I footprinting analyses revealed that Sp1 specifically interacts with the CACCC motif."
] | [
"(G/T)GGGCGG(G/A)(G/A)(C/T)"
] | [
"a GC-rich element (Sp1-binding site)",
"Further analysis revealed that the DNA sequence, TTCAAGTCCCGCCCTCCGCT from -65 to -46",
"Sp1 motif in the UCR",
"upstream control region (UCR) containing a GC-rich motif (5'-GGGCGGG-3') and to a unique enhancer core (5'-TGCGGTC-3')",
"A GC-rich region containing Sp1 ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10777687",
"http://www.ncbi.nlm.nih.gov/pubmed/8063775",
"http://www.ncbi.nlm.nih.gov/pubmed/8702907",
"http://www.ncbi.nlm.nih.gov/pubmed/9261349",
"http://www.ncbi.nlm.nih.gov/pubmed/12684058",
"http://www.ncbi.nlm.nih.gov/pubmed/22021377"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016329"
] |
56f8077a8b98c98849000002 | list | List autoimmune disorders associated with GAD65 autoantibodies. | [
"Autoantibodies to the smaller isoform of glutamate decarboxylase (GAD) can be found in patients with type 1 diabetes and a number of neurological disorders, including stiff-person syndrome, cerebellar ataxia and limbic encephalitis."
] | [
"type 1 diabetes",
"stiff-person syndrome",
"cerebellar ataxia",
"limbic encephalitis"
] | [
"Evidence for somatic mutation and affinity maturation of diabetes associated human autoantibodies to glutamate decarboxylase.",
"The circulating autoantibodies to multiple islet autoantigens including GAD, insulin, and IA-2 are the important immunological features of type 1 diabetes. ",
"100% (39/39) selected ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25566057",
"http://www.ncbi.nlm.nih.gov/pubmed/12691864",
"http://www.ncbi.nlm.nih.gov/pubmed/8816973",
"http://www.ncbi.nlm.nih.gov/pubmed/25870548",
"http://www.ncbi.nlm.nih.gov/pubmed/9451598",
"http://www.ncbi.nlm.nih.gov/pubmed/14679108"
] | [] | [] |
56acd7530a360a5e45000004 | summary | Elaborate on the TREAT-NMD initiative for DMD patients | [
"TREAT-NMD is a worldwide network for neuromuscular diseases that provides an infrastructure to support the delivery of promising new therapies for patients in Europe. TREAT-NMD has worked on the generation of brief standards of care for DMD. Guidelines are presented for diagnostics, neurological follow up, gastroi... | [] | [
"TREAT-NMD is a worldwide network for neuromuscular diseases that provides an infrastructure to support the delivery of promising new therapies for patients.",
"The TREAT-NMD care and trial site registry: an online registry to facilitate clinical research for neuromuscular diseases.",
"TREAT-NMD Care and Trial ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20225016",
"http://www.ncbi.nlm.nih.gov/pubmed/24148153",
"http://www.ncbi.nlm.nih.gov/pubmed/23913485",
"http://www.ncbi.nlm.nih.gov/pubmed/22068481"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A0098343",
"o": "D010361"
},
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A0098257",
"o": "D010361"
}
] | [
"http://www.uniprot.org/uniprot/DMD_CANLF",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010361",
"http://www.uniprot.org/uniprot/DMD_HUMAN",
"http://www.uniprot.org/uniprot/DMD_RAT",
"http://www.uniprot.org/uniprot/DMD_CHICK",
"http://www.uniprot.org/uniprot/DMD_PIG"... |
57134d511174fb1755000002 | yesno | Is muscle regeneration possible in mdx mice with the use of induced mesenchymal stem cells? | [
"Purified induced mesenchymal stem cells (iMSCs) display fibroblast-like morphology, form three-dimensional spheroid structures, express characteristic mesenchymal stem cell surface markers such as CD29, CD33, CD73, CD90, and CD105, and are capable of differentiating into adipogenic, osteogenic, and chondrogenic li... | [
"yes"
] | [
"Purified iMSCs displayed fibroblast-like morphology, formed three-dimensional spheroid structures, and expressed characteristic mesenchymal stem cell surface markers such as CD29, CD33, CD73, CD90, and CD105. Moreover, iMSCs were capable of differentiating into adipogenic, osteogenic, and chondrogenic lineages. Tr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25102299"
] | [] | [] |
5503145ee9bde69634000022 | list | List the different subtypes of thyroid cancer. | [
"The different histologic subtypes of thyroid cancer include papillary, follicular, anaplastic, medullary, and Hürthle cell carcinomas."
] | [
"Papillary thyroid carcinoma",
"Follicular thyroid carcinoma",
"Anaplastic thyroid carcinoma",
"Medullary thyroid carcinoma",
"Hürthle cell carcinoma"
] | [
"Thyroid cancer is the most common cancer of the endocrine system and is responsible for the majority of deaths from endocrine malignancies. Although a large proportion of thyroid cancers belong to well differentiated histologic subtypes, which in general show a good prognosis after surgery and radioiodine ablation... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17985985",
"http://www.ncbi.nlm.nih.gov/pubmed/20969692",
"http://www.ncbi.nlm.nih.gov/pubmed/21169742",
"http://www.ncbi.nlm.nih.gov/pubmed/21553140",
"http://www.ncbi.nlm.nih.gov/pubmed/8608779",
"http://www.ncbi.nlm.nih.gov/pubmed/21272686",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:1781"
] |
571e469bbb137a4b0c00000d | summary | What are the characteristics of Christianson syndrome? | [
"Christianson syndrome (CS) is caused by mutations in the X-linked Na(+) /H(+) exchanger 6 (NHE6). Patients present with prominent neurological, medical, and behavioral symptoms. All CS participants were nonverbal and had intellectual disability, epilepsy, and ataxia. Other neurologic symptoms included eye movement... | [] | [
"Recently, Christianson syndrome (CS) has been determined to be caused by mutations in the X-linked Na(+) /H(+) exchanger 6 (NHE6). ",
"We also report prominent neurological, medical, and behavioral symptoms. All CS participants were nonverbal and had intellectual disability, epilepsy, and ataxia. Many had prior ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24630051",
"http://www.ncbi.nlm.nih.gov/pubmed/18342287",
"http://www.ncbi.nlm.nih.gov/pubmed/24035762",
"http://www.ncbi.nlm.nih.gov/pubmed/25044251",
"http://www.ncbi.nlm.nih.gov/pubmed/25273398",
"http://www.ncbi.nlm.nih.gov/pubmed/20949524",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020969",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004827",
"http://www.disease-ontology.org/a... |
571e06447de986d80d000016 | yesno | Is the SDHAF2 gene encoding a protein necessary for flavination of SDHA? | [
"Yes, SDHAF2 or hSDH5, is the gene encoding the enzyme responsible for the flavination of SDHA.",
"Yes, SDHAF2 is required for flavination of SDHA."
] | [
"yes"
] | [
"Pheochromocytoma-paraganglioma syndrome is caused by mutations in SDHB, SDHC, and SDHD, encoding subunits of succinate dehydrogenase (SDH), and in SDHAF2, required for flavination of SDHA. ",
"At present, these are RET proto-oncogene, von Hippel-Lindau disease tumor suppressor gene (VHL), neurofibromatosis type ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21752896",
"http://www.ncbi.nlm.nih.gov/pubmed/23036115",
"http://www.ncbi.nlm.nih.gov/pubmed/19732718",
"http://www.ncbi.nlm.nih.gov/pubmed/23061808"
] | [] | [] |
53175e9fb166e2b80600000a | factoid | What is the physiological role of LKB1 involved in Peutz-Jeghers syndrome? | [
"LKB1 plays a physiological role in controlling the Wnt-signaling."
] | [
"LKB1 plays a physiological role in controlling the Wnt-signaling."
] | [
"Recent functional genetic studies have pointed out that LKB1 plays a physiological role in controlling the Wnt-signaling pathway and activation of the pathway as a consequence of LKB1 haploinsufficiency might be responsible for the development of harmatomatous polyps.",
"PJS polyps from all patients showed gener... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20020146"
] | [] | [
"http://www.uniprot.org/uniprot/STK11_HUMAN",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010580",
"http://www.disease-ontology.org/api/metadata/DOID:3852"
] |
55479102f35db75526000004 | summary | What heterotachy states about molecular evolutionary processes? | [
"Functional constraints may account for heterogeneity in the evolutionary rates among different sites of amino acid or DNA sequences. Apart from variations of substitution rates among different sites (spatial variation), heterotachy states that there are variations of substitution rates of a given site throughout t... | [] | [
"One of the properties of protein evolution is the variation of the relative rate of substitutions across sites and over time, the latter is the phenomenon called heterotachy.",
"Heterotachy is a general term to describe positions that evolve at different rates in different lineages.",
"There is widespread evid... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19687305",
"http://www.ncbi.nlm.nih.gov/pubmed/20724379",
"http://www.ncbi.nlm.nih.gov/pubmed/19822637",
"http://www.ncbi.nlm.nih.gov/pubmed/17366138",
"http://www.ncbi.nlm.nih.gov/pubmed/12880207",
"http://www.ncbi.nlm.nih.gov/pubmed/19482090",
"http://www.ncbi.nlm.n... | [] | [] |
530f72fd329f5fcf1e000003 | summary | What is known about depression in caregivers of brain tumor patients? | [
"Depression is common affecting up to 40% of caregivers of brain tumor patients. Depression is associated with poor quality of life of caregivers of brain tumor patients. Greater anxiety, patients’ emotional distress, economic hardship, lower caregivers’ age, lower income, less social support and lower patient func... | [] | [
"Data suggest that patients with primary or metastatic brain tumours often have a high symptom burden and unmet needs for palliative care, and symptoms are hard to diagnose; patients suffer often and early from cognitive impairment but are rarely appropriately prepared concerning end-of-life wishes. This reflects o... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12605978",
"http://www.ncbi.nlm.nih.gov/pubmed/23104453",
"http://www.ncbi.nlm.nih.gov/pubmed/18481737",
"http://www.ncbi.nlm.nih.gov/pubmed/21994513",
"http://www.ncbi.nlm.nih.gov/pubmed/19159080",
"http://www.ncbi.nlm.nih.gov/pubmed/23438646",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001932",
"http://www.disease-ontology.org/api/metadata/DOID:1596",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003866",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Ex... |
55391825bc4f83e828000016 | summary | What are the effects of homozygosity of EDNRB mutations in addition to Hirschsprung disease? | [
"Three susceptibility genes have been recently identified in HSCR, namely the RET proto-oncogene, the endothelin B receptor (EDNRB) gene, and the endothelin 3 (EDN3) gene. RET gene mutations were found in significant proportions of familial (50%) and sporadic (15-20%) HSCR, while homozygosity for EDNRB or EDN3 muta... | [] | [
"Homozygous mutations of EDNRB in human have been reported to result in Waardenburg-Hirschsprung disease (WS4), while mutated heterozygotes manifested isolated Hirschsprung disease in lower penetrance",
"The index patient, who was born to a family with no history of Hirschsprung disease, presented total colonic a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16237557",
"http://www.ncbi.nlm.nih.gov/pubmed/12939697",
"http://www.ncbi.nlm.nih.gov/pubmed/11324313",
"http://www.ncbi.nlm.nih.gov/pubmed/11891690",
"http://www.ncbi.nlm.nih.gov/pubmed/9885824",
"http://www.ncbi.nlm.nih.gov/pubmed/8852660"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006627",
"http://www.disease-ontology.org/api/metadata/DOID:10487"
] |
53265dd4d6d3ac6a34000007 | factoid | What is the prognostic role of alterred thyroid profile after cardiosurgery? | [
"Altered thyroid profile after cardiosurgery is associated with high incidence of atrial fibrillation e delay in recovery (prolonged hospitalisation) in adults and higher score on The Pediatric Risk of Mortality (PRISM; P < 0.042) and a longer duration of ventilation in children.Impportantly in transplanted patient... | [
"Altered thyroid profile after cardiosurgery is associated with several events in adults and in children"
] | [
" Patients with fT3 syndrome had the highest mortality (16.7%, NS), highest incidence of acute rejection (38.9%, NS), highest number of reoperations (27.8%, NS), and highest incidence of bacterial (16.7%, NS) and fungal infections (11.1%, NS).",
"SCH appears to influence the postoperative outcome for patients by ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12475369",
"http://www.ncbi.nlm.nih.gov/pubmed/14500064",
"http://www.ncbi.nlm.nih.gov/pubmed/16677263",
"http://www.ncbi.nlm.nih.gov/pubmed/21959513",
"http://www.ncbi.nlm.nih.gov/pubmed/21097430",
"http://www.ncbi.nlm.nih.gov/pubmed/19303793",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010361",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013903",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013959",
"http://www.nlm.nih.gov/cgi/mesh/2... |
56be15ffef6e39474100000b | list | List Pentalogy of Fallot. | [
"Pentalogy of Fallot consists of a pulmonic stenosis, a ventricular septal defect, an overriding aorta, a right ventricular hypertrophy and a patent foramen ovale."
] | [
"pulmonic stenosis",
"ventricular septal defect",
"overriding aorta",
"right ventricular hypertrophy",
"patent foramen ovale"
] | [
"Pentalogy of Fallot (POF) is a rare form of congenital heart disease characterized by the association of Tetralogy of Fallot (TOF) with an atrial septal defect (ASD).",
"Additionally, an atrial septal defect was found on necropsy, resulting in the final diagnosis of Tetralogy of Fallot with an atrial septal defe... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24594084",
"http://www.ncbi.nlm.nih.gov/pubmed/17283405",
"http://www.ncbi.nlm.nih.gov/pubmed/22461877",
"http://www.ncbi.nlm.nih.gov/pubmed/26393185",
"http://www.ncbi.nlm.nih.gov/pubmed/11432800",
"http://www.ncbi.nlm.nih.gov/pubmed/23758042"
] | [] | [] |
56f6d4ed09dd18d46b000010 | summary | Which is the major function of sororin? | [
"Sororin is a positive regulator of sister chromatid cohesion that interacts with the cohesin complex."
] | [] | [
"Sororin pre-mRNA splicing is required for proper sister chromatid cohesion in human cells.",
"ororin accumulation during S phase, and are, therefore, essential to the maintenance of genome stability.",
"Defective sister chromatid cohesion is a general consequence of dysfunctional pre-mRNA splicing, resulting f... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21111234",
"http://www.ncbi.nlm.nih.gov/pubmed/25173175",
"http://www.ncbi.nlm.nih.gov/pubmed/25266476",
"http://www.ncbi.nlm.nih.gov/pubmed/23901111",
"http://www.ncbi.nlm.nih.gov/pubmed/22101327",
"http://www.ncbi.nlm.nih.gov/pubmed/25220052",
"http://www.ncbi.nlm.n... | [] | [] |
55149f156a8cde6b72000013 | factoid | Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation? | [
"Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called the Philadelphia (Ph) chromosome. The Philadelphia chromosome and its corresponding fusion gene, BCR-ABL, is one of... | [
"The BCR/ABL gene fusion",
"ABL/BCR fusion"
] | [
"Philadelphia (Ph) chromosome positive acute lymphoblastic leukemia (ALL) is a common cytogenetic abnormality associated with poor outcome in adults. This preliminary study, in the absence of substantial evidence, reported the prevalence of the BCR-ABL gene fusion in ALL patients by RT-PCR in Pakistan.",
"The Phi... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17987804",
"http://www.ncbi.nlm.nih.gov/pubmed/16616117",
"http://www.ncbi.nlm.nih.gov/pubmed/3670297",
"http://www.ncbi.nlm.nih.gov/pubmed/21279819",
"http://www.ncbi.nlm.nih.gov/pubmed/8697423",
"http://www.ncbi.nlm.nih.gov/pubmed/9916508",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010677",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014178"
] |
530cf4fe960c95ad0c00000a | yesno | Is zolpidem an antibiotic? | [
"No, zolpidem is a short-acting imidazopyridine hypnotic drug"
] | [
"no"
] | [
"Zolpidem is a short-acting imidazopyridine hypnotic drug that is metabolized mainly by CYP3A4.",
"FGIN-1-27 and alpidem, like the neurosteroid 3 alpha,21-dehydroxy-5 alpha-pregnane-20-one (THDOC), clonazepam and zolpidem (the direct allosteric modulators of gamma-aminobutyric acidA receptors) delay the onset of ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8098760",
"http://www.ncbi.nlm.nih.gov/pubmed/9433391",
"http://www.ncbi.nlm.nih.gov/pubmed/11154097",
"http://www.ncbi.nlm.nih.gov/pubmed/1403792",
"http://www.ncbi.nlm.nih.gov/pubmed/2871178"
] | [] | [
"http://www.biosemantics.org/jochem#4205693",
"http://www.biosemantics.org/jochem#4259685",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000900"
] |
530cf4fe960c95ad0c00000c | yesno | Can desvenlafaxine be used at a dose of 50mg/day? | [
"Yes, desvenlafaxine can be at 50mg/day to treat patients with major depressive disorder. Studies suggest that 50 mg is the minimum effective dose of desvenlafaxine for the treatment of major depressive disorder. The recommended dose of DVS ranges from 50 to 100 mg."
] | [
"yes"
] | [
"Long-term use of desvenlafaxine was safe and well tolerated, with a clinical benefit/risk profile similar to that in other populations.",
"e objective of this study was to evaluate the long-term safety of desvenlafaxine for continuation treatment of major depressive disorder (MDD) in Japanese patients. This was ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23587982",
"http://www.ncbi.nlm.nih.gov/pubmed/21067460",
"http://www.ncbi.nlm.nih.gov/pubmed/23881185",
"http://www.ncbi.nlm.nih.gov/pubmed/20107296",
"http://www.ncbi.nlm.nih.gov/pubmed/18507895",
"http://www.ncbi.nlm.nih.gov/pubmed/23517291",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A15520455",
"o": "790287"
},
{
"p": "http://linkedlifedata.com/resource/umls/prefMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C2341627",
"o": "http://linkedlifedata.co... | [
"http://www.biosemantics.org/jochem#4266016",
"http://www.biosemantics.org/jochem#4243854"
] |
571e40a8bb137a4b0c000009 | factoid | Which syndrome is associated with OATP1B1 and OATP1B3 deficiency? | [
"Complete and simultaneous deficiency of the organic anion transporting polypeptides OATP1B1 and OATP1B3 due to mutations in their corresponding genes, has been linked to Rotor syndrome."
] | [
"Rotor syndrome"
] | [
"Here, we analyzed 8 Rotor-syndrome families and found that Rotor syndrome was linked to mutations predicted to cause complete and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP1B3.",
"Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22982575",
"http://www.ncbi.nlm.nih.gov/pubmed/22232210"
] | [] | [] |
530cf4fe960c95ad0c00000b | factoid | Which type of lung cancer is afatinib used for? | [
"Afatinib is a small molecule covalently binding and inhibiting the EGFR, HER2 and HER4 receptor tyrosine kinases. Trials showed promising efficacy in patients with EGFR-mutant NSCLC or enriched for clinical benefit from EGFR tyrosine kinase inhibitors gefitinib or erlotinib.",
"Afatinib is a novel irreversible i... | [
"EGFR-mutant non small cell lung carcinoma",
"EGFR-mutant NSCLC"
] | [
"Afatinib is a novel irreversible inhibitor of the ErbB family members EGFR, tyrosine kinase-type cell surface receptors HER2 and HER4. It shows preclinical efficacy in NSCLC with common EGFR-activating mutations and the T790M mutation typically associated with EGFR TKI resistance",
"At present, only first-genera... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21554040",
"http://www.ncbi.nlm.nih.gov/pubmed/22452896",
"http://www.ncbi.nlm.nih.gov/pubmed/24086949",
"http://www.ncbi.nlm.nih.gov/pubmed/18408761",
"http://www.ncbi.nlm.nih.gov/pubmed/23664448",
"http://www.ncbi.nlm.nih.gov/pubmed/18520300",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009369",
"http://www.disease-ontology.org/api/metadata/DOID:3683",
"http://www.disease-ontology.org/api/metadata/DOID:7696",
"http://www.disease-ontology.org/api/metadata/DOID:3908",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_c... |
530cf4fe960c95ad0c00000d | yesno | Can ferric carboxymaltose be used to treat anemia in inflammatory bowel disease patients? | [
"Ferric carboxymaltose can be used to treat anemia in patients with inflammatory bowel disease, and prevents recurrence of anemia in these patients, compared with placebo. Treatment with ferric carboxymaltose is efficious, safe and well tolerated in iron-deficient IBD patients."
] | [
"yes"
] | [
"Intravenous iron should be preferred where oral iron is poorly tolerated or where it has failed in moderate to severe anemia, and in combination with erythropoietin",
"Ferric carboxymaltose is much more convenient, and has been shown to be more effective than iron sucrose in a large randomized tria",
"nemia an... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21699794",
"http://www.ncbi.nlm.nih.gov/pubmed/21340038",
"http://www.ncbi.nlm.nih.gov/pubmed/24114623",
"http://www.ncbi.nlm.nih.gov/pubmed/23078888",
"http://www.ncbi.nlm.nih.gov/pubmed/23889159",
"http://www.ncbi.nlm.nih.gov/pubmed/19787830",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A13386134",
"o": "C522335"
},
{
"p": "http://linkedlifedata.com/resource/umls/prefMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C2001867",
"o": "http://linkedlifedata.c... | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003093",
"http://www.disease-ontology.org/api/metadata/DOID:2355",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005290",
"http://www.disease-ontology.org/api/metadata/DOID:0050589",
"http... |
56c1f009ef6e39474100003c | factoid | Which disease is treated with Eliglustat? | [
"Eliglustat was developed for treatment of Gaucher's disease type 1."
] | [
"Gaucher's disease type 1"
] | [
"Eliglustat compared with imiglucerase in patients with Gaucher's disease type 1 stabilised on enzyme replacement therapy: a phase 3, randomised, open-label, non-inferiority trial.",
"We investigated whether patients stable on such treatment would remain so after switching to oral eliglustat, a selective inhibito... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25256118",
"http://www.ncbi.nlm.nih.gov/pubmed/25688781",
"http://www.ncbi.nlm.nih.gov/pubmed/24835462",
"http://www.ncbi.nlm.nih.gov/pubmed/20864621",
"http://www.ncbi.nlm.nih.gov/pubmed/25819691",
"http://www.ncbi.nlm.nih.gov/pubmed/20439622",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019468",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004194"
] |
5333f728d6d3ac6a34000041 | list | List algorithms suitable for predicting protein complexes | [
"Protein-Protein interactions (PPI) play a key role in determining the outcome of most cellular processes. The correct identification and characterization of protein interactions and the networks, which they comprise, is critical for understanding the molecular mechanisms within the cell. Large-scale techniques suc... | [
"Naïve Bayes Classifier",
"Negatome",
"Support Vector Machine",
"PEWCC",
"iPTMClust",
"NDComplex",
"PROCOMOSS",
"PPI network",
"metaPIS",
"EPOF",
"EAGLE",
"NFC",
"MCODE",
"DPClus",
"IPCA",
"CPM",
"MCL",
"CMC",
"SPICi",
"Core-Attachment",
"ProRank",
"ClusterONE",
"CFinder"... | [
"Protein complexes are basic cellular entities that carry out the functions of their components",
"we have designed several features characterizing heterodimeric protein complexes based on genomic data sets, and proposed a supervised-learning method for the prediction of heterodimeric protein complexes. This meth... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16872538",
"http://www.ncbi.nlm.nih.gov/pubmed/24299017",
"http://www.ncbi.nlm.nih.gov/pubmed/22174556",
"http://www.ncbi.nlm.nih.gov/pubmed/21682895",
"http://www.ncbi.nlm.nih.gov/pubmed/19534736",
"http://www.ncbi.nlm.nih.gov/pubmed/23419374",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005544",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000465",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field... |
56c4bbfdb04e159d0e000002 | summary | What are piggyBAC transposons? | [
"The piggyBAC transposons are a nonviral gene delivery approach, that have been developed as tools for insertional mutagenesis. It can mobilize 100-kb DNA fragments in mouse embryonic stem (ES) cells, making it the only known transposon with such a large cargo capacity. The integrity of the cargo is maintained dur... | [] | [
"The Sleeping Beauty and PiggyBac DNA transposon systems have recently been developed as tools for insertional mutagenesis. ",
"The use of nonviral gene delivery approaches in conjunction with the latest generation transposon technology based on Sleeping Beauty (SB) or piggyBac transposons may potentially overcom... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19391106",
"http://www.ncbi.nlm.nih.gov/pubmed/21948799",
"http://www.ncbi.nlm.nih.gov/pubmed/23358416",
"http://www.ncbi.nlm.nih.gov/pubmed/24164672",
"http://www.ncbi.nlm.nih.gov/pubmed/22155246",
"http://www.ncbi.nlm.nih.gov/pubmed/21447194",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004251"
] |
54d63d873706e89528000006 | yesno | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | [
"Yes, genome-wide significant associations in schizophrenia has been linked to the locus harboring the ITIH3/4 genes."
] | [
"yes"
] | [
"The most widely shared subset of genes-common to five of six disorders-included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1. ",
"Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22614287",
"http://www.ncbi.nlm.nih.gov/pubmed/24373612",
"http://www.ncbi.nlm.nih.gov/pubmed/25136889",
"http://www.ncbi.nlm.nih.gov/pubmed/25414627",
"http://www.ncbi.nlm.nih.gov/pubmed/24618187",
"http://www.ncbi.nlm.nih.gov/pubmed/24461634",
"http://www.ncbi.nlm.n... | [
{
"p": "http://purl.uniprot.org/core/encodedBy",
"s": "http://purl.uniprot.org/uniprot/P56652",
"o": "http://linkedlifedata.com/resource/#_5035363635320014"
},
{
"p": "http://purl.uniprot.org/core/shortName",
"s": "http://linkedlifedata.com/resource/#_5035363635320011",
"o": "Inter-alpha... | [
"http://www.disease-ontology.org/api/metadata/DOID:1229",
"http://www.uniprot.org/uniprot/ITIH3_HUMAN",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012559",
"http://www.uniprot.org/uniprot/ITIH3_RABIT",
"http://www.biosemantics.org/jochem#4252946",
"http://www.unipro... |
54e0ace81388e8454a000010 | factoid | Is APOBEC3B protein predominantly cytoplasmic or nuclear? | [
"Contrary to other APOBEC family members, APOBEC3B was found to predominantly concentrate to the cell nucleus."
] | [
" nuclear"
] | [
"A3B is the only family member with steady-state nuclear localization",
"Here, we show that A3B nuclear import is an active process requiring at least one amino acid (Val54) within an N-terminal motif analogous to the nuclear localization determinant of the antibody gene diversification enzyme AID (activation-ind... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21715505",
"http://www.ncbi.nlm.nih.gov/pubmed/18667511",
"http://www.ncbi.nlm.nih.gov/pubmed/23388464",
"http://www.ncbi.nlm.nih.gov/pubmed/22446380",
"http://www.ncbi.nlm.nih.gov/pubmed/16648136",
"http://www.ncbi.nlm.nih.gov/pubmed/23389445"
] | [] | [
"http://www.uniprot.org/uniprot/ABC3B_HUMAN"
] |
553fbe9fe00431e071000001 | yesno | Is the regulation of Vsr endonuclease independent of the growth phase of bacteria? | [
"The regulation of Vsr endonuclease levels is growth phase dependent."
] | [
"no"
] | [
"Growth phase-dependent regulation of Vsr endonuclease",
"Vsr endonuclease levels are growth phase dependent.",
"Growth phase-dependent regulation of Vsr endonuclease may contribute to 5-methylcytosine mutational hot spots in Escherichia coli.",
"Using rabbit polyclonal antibodies, we have shown that the Dcm ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10400606",
"http://www.ncbi.nlm.nih.gov/pubmed/15184558",
"http://www.ncbi.nlm.nih.gov/pubmed/12067333",
"http://www.ncbi.nlm.nih.gov/pubmed/9537396"
] | [] | [
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043765",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519"
] |
56c85f675795f9a73e000013 | yesno | Are there interactomes available for POU5F1 and SOX2? | [
"Yes. Long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) have been assayed using 4C-Seq technique. Their frequent interacting regions mainly overlap with early DNA replication domains. The interactomes are associated with active histone marks and... | [
"yes"
] | [
"The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells.",
"We assayed long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) using 4C-Seq technique. We discovered that their frequent interacting regions mainly overlap with ear... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23549118"
] | [] | [
"http://www.uniprot.org/uniprot/NANOG_PANTR",
"http://www.uniprot.org/uniprot/NANOG_HUMAN",
"http://www.uniprot.org/uniprot/PO5F1_PANTR",
"http://www.uniprot.org/uniprot/SOX2_DANRE",
"http://www.uniprot.org/uniprot/NANOG_MUSMM",
"http://www.uniprot.org/uniprot/PO5F1_BOVIN",
"http://www.uniprot.org/unipr... |
56afe6d40a360a5e45000017 | factoid | Which tool is used for promoterome mining using CAGE data? | [
"Despite their high resolution and functional significance, published CAGE data are still underused in promoter analysis due to the absence of tools that enable its efficient manipulation and integration with other genome data types. CAGEr is an R implementation of novel methods for the analysis of differential TSS... | [
"CAGEr"
] | [
"CAGEr: precise TSS data retrieval and high-resolution promoterome mining for integrative analyses.",
" Despite their high resolution and functional significance, published CAGE data are still underused in promoter analysis due to the absence of tools that enable its efficient manipulation and integration with ot... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25653163"
] | [] | [] |
515ae990d24251bc050000ad | yesno | Is Rheumatoid Arthritis related to myopathy? | [
"Vacuolar myopathy and statin-induced myopathy have been reported in rheumatoid arthritis patients, but this association may be due to the anti-malarial treatment received. An increased prevalence of neurogenic but not myogenic changes in patients with RA compared with controls has been reported."
] | [
"yes"
] | [
"Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients",
"we describe a patient with rheumatoid arthritis and respiratory failure associated with proximal myopathy secondary to HCQ",
"Occurrence of chloroquine-induced myopathy after low-dose treatment of rheumatoid arthritis fo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12682624",
"http://www.ncbi.nlm.nih.gov/pubmed/19642078",
"http://www.ncbi.nlm.nih.gov/pubmed/17296665",
"http://www.ncbi.nlm.nih.gov/pubmed/10555889",
"http://www.ncbi.nlm.nih.gov/pubmed/12652413",
"http://www.ncbi.nlm.nih.gov/pubmed/15909088",
"http://www.ncbi.nlm.n... | [] | [] |
532f03e6d6d3ac6a34000022 | summary | what is the role of GATA-4 in regeneration of the heart after myocardial infarction? | [
"GATA-4 is implicated in cardiogenic differentiation of cardiac c-kit+AT2+ cells that represent approximately 0.19% of total cardiac cells in infarcted heart. GATA-4 overexpression in mesenchymal stem cells increases both survival and angiogenic potential in ischemic myocardium and may therefore represent a novel a... | [] | [
"TGF-beta conducted the myogenic differentiation of CD117+ stem cells by upregulating GATA-4 and NKx-2.5 expression. Therefore, the intramyocardial implantation of TGF-beta-preprogrammed CD117+ cells effectively assisted the myocardial regeneration and induced therapeutic angiogenesis, contributing to functional ca... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22748493",
"http://www.ncbi.nlm.nih.gov/pubmed/19591228",
"http://www.ncbi.nlm.nih.gov/pubmed/21344679",
"http://www.ncbi.nlm.nih.gov/pubmed/20870802",
"http://www.ncbi.nlm.nih.gov/pubmed/22898045",
"http://www.ncbi.nlm.nih.gov/pubmed/20200331",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006321",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D050980",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009203",
"http://www.nlm.nih.gov/cgi/mesh/2... |
52e62bae98d0239505000015 | factoid | What is the life expectancy of professional athletes in respect to the general population? | [
"Elite endurance (aerobic) athletes and mixed-sports (aerobic and anaerobic) athletes show higher longevity than the general population, but results about power (anaerobic) athletes are inconsistent.",
"It remains unclear if high-intensity sports activities further increase life expectancy.\nCompetitive exercise... | [
"longer than the general population",
"No clear results indicating improved life expectancy in professional athletes"
] | [
"In conclusion, while regular physical activity increases life expectancy, it remains unclear if high-intensity sports activities further increase life expectancy.",
"Competitive exercise does not induce cardiac damage in individuals with healthy hearts, but does induce physiological functional and structural car... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17849604",
"http://www.ncbi.nlm.nih.gov/pubmed/8450727",
"http://www.ncbi.nlm.nih.gov/pubmed/17436206",
"http://www.ncbi.nlm.nih.gov/pubmed/19574095",
"http://www.ncbi.nlm.nih.gov/pubmed/16389882",
"http://www.ncbi.nlm.nih.gov/pubmed/9177584",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013177",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008017",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056352",
"http://www.nlm.nih.gov/cgi/mesh/2... |
570908e3cf1c325851000012 | yesno | Is EZH2 associated with prostate cancer? | [
"EZH2 is an epigenetic driver of prostate cancer. EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer. EZH2 plays an active role in this process by repressing the expression of TIMP2 and TIMP3 in prostate cancer cells. EZH2 knockdown markedly reduces the proteolytic activity of MMP... | [
"yes"
] | [
"The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells",
"EZH2 plays an active role in this process by repressing the expression of TIMP2 and TIMP3 in prostate cancer cells",
"The TIMP genes are derepressed by knockdown of EZH2 expression in human prostate canc... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21941025",
"http://www.ncbi.nlm.nih.gov/pubmed/24375374",
"http://www.ncbi.nlm.nih.gov/pubmed/23739676",
"http://www.ncbi.nlm.nih.gov/pubmed/17134822",
"http://www.ncbi.nlm.nih.gov/pubmed/16330673",
"http://www.ncbi.nlm.nih.gov/pubmed/22505648",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/EZH2_HUMAN",
"http://www.disease-ontology.org/api/metadata/DOID:10283",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011471",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011467",
"http://www.disease-... |
516d5bdf298dcd4e5100007a | summary | How does adrenergic signaling affect thyroid hormone receptors? | [
"alpha1- adrenergic signalling increases TRalpha1 expression in nucleus and decreases TRalpha1 expression in cytosol."
] | [] | [
"PE, in the absence of T3, resulted in 5.0 fold increase in TRalpha1 expression in nucleus and 2.0 fold decrease in TRalpha1 expression in cytosol, P<0.05.",
"nuclear TRalpha1 is overexpressed after prolonged activation of the alpha1- adrenergic signalling by PE. This response seems to be an ERK kinase dependent ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18622044"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011988",
"http://www.uniprot.org/uniprot/THB_PAROL",
"http://www.uniprot.org/uniprot/THA_HIPHI",
"http://www.uniprot.org/uniprot/THA_SPAAU",
"http://www.uniprot.org/uniprot/THA_RAT",
"http://www.uniprot.org/uniprot/THA_ONCM... |
51434c74d24251bc0500000c | list | What are the computational tools for the prediction of beta-barrel transmembrane proteins? | [
"The computational tools for the prediction of beta-barrel transmembrane proteins (TMBs) are based mainly on the following methodologies: Hidden Markov Models (HMMs), hydrophobicity, structural data, k-nearest neighbor algorithm, Neural Networks and Support Vector Machines. The state-of-the-art computational tools ... | [
"BETAWARE",
"BOCTOPUS",
"BOMP",
"BTMX",
"HMM-B2TMR",
"OMPdb",
"PRED-TMBB",
"PROB",
"ProfTMB",
"PV",
"TMB finding pipeline",
"TMBETADISC-RBF",
"TMBETAPRED-RBF",
"TMBHMM",
"TMB-Hunt",
"TMB-Hunt2",
"TMBKNN",
"TMBpro",
"transFold",
"TMBETA-NET"
] | [
"In this work, we propose a method based on radial basis networks for predicting the number of beta-strands in OMPs and identifying their membrane spanning segments.",
"We have developed a web server, TMBETAPRED-RBF for predicting the transmembrane beta-strands from amino acid sequence and it is available at http... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15647112",
"http://www.ncbi.nlm.nih.gov/pubmed/16844989",
"http://www.ncbi.nlm.nih.gov/pubmed/16844988",
"http://www.ncbi.nlm.nih.gov/pubmed/15980447",
"http://www.ncbi.nlm.nih.gov/pubmed/18434251",
"http://www.ncbi.nlm.nih.gov/pubmed/16351738",
"http://www.ncbi.nlm.n... | [] | [] |
56cdf4675795f9a73e00003f | summary | Which kinase is regulating stress granule biogenesis? | [
"5'-AMP-activated protein kinase alpha regulates stress granule biogenesis",
"Multiple lines of evidence define the master metabolic regulator 5'-AMP-activated protein kinase alpha (AMPK-alpha) as a novel component of stress granules (SGs) that also controls their biogenesis."
] | [] | [
"5'-AMP-activated protein kinase alpha regulates stress granule biogenesis",
"Multiple lines of evidence link AMPK activity to SG biogenesis. First, pharmacological kinase inhibition interfered with SG formation. Second, AMPK-α knockdown combined with in-depth quantitative SG analysis revealed isoform-specific ch... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25840010"
] | [] | [] |
530e1b205937551c09000003 | summary | What is the association between cell phone use and glioblastoma? | [
"The association between cell phone use and incident glioblastoma remains unclear. Some studies have reported that cell phone use was associated with incident glioblastoma, and with reduced survival of patients diagnosed with glioblastoma. However, other studies have repeatedly replicated to find an association bet... | [] | [
"Decreased survival of glioma cases with long-term and high cumulative use of wireless phones was found. ",
"There was no significant association between glioma and alcohol consumption, smoking and mobile phone use.",
"Regular cell phone use was not associated with an increased risk of neuroma (OR=0,92; 95% con... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24348390",
"http://www.ncbi.nlm.nih.gov/pubmed/24064953",
"http://www.ncbi.nlm.nih.gov/pubmed/19261451",
"http://www.ncbi.nlm.nih.gov/pubmed/20215713",
"http://www.ncbi.nlm.nih.gov/pubmed/18941554",
"http://www.ncbi.nlm.nih.gov/pubmed/16804530",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D040421",
"http://www.disease-ontology.org/api/metadata/DOID:3068",
"http://www.disease-ontology.org/api/metadata/DOID:3073",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005909"
] |
5319a7b2b166e2b806000028 | yesno | Is there any cross-talk between the Wnt and the Akt pathways? | [
"The Wnt/β-catenin and PI3K/Akt signaling pathways cross-talk mainly through the activity of GSK-3β, a common component of both pathways, but also through the activity of other signaling transducers, such as Cby or WISP-1."
] | [
"yes"
] | [
"Our data demonstrate that engaging Wnt signaling at the receptor level by this method leads to necessary crosstalk between multiple signaling pathways including activation of Akt, mTOR, Wnt/β-catenin, PKA/CREB, and inhibition of RhoA/ROCK that substantially increase human β-cell proliferation while maintaining the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22337886",
"http://www.ncbi.nlm.nih.gov/pubmed/18687666",
"http://www.ncbi.nlm.nih.gov/pubmed/19158508",
"http://www.ncbi.nlm.nih.gov/pubmed/19850932",
"http://www.ncbi.nlm.nih.gov/pubmed/19887570",
"http://www.ncbi.nlm.nih.gov/pubmed/20888802",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020239",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030111",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043491",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:... |
5523e8cc7b523f2123000007 | yesno | Has the protein GFP been used in transgenesis for live protein imaging? | [
"Yes, the stable transgenesis of genes encoding functional or spatially localized proteins, fused to fluorescent proteins such as green fluorescent protein (GFP) or red fluorescent protein (RFP), is an extremely important research tool in cell and developmental biology."
] | [
"yes"
] | [
"we review recent advancement in the functional studies of the three different GnRH neuron systems, mainly focusing on the electrophysiological analysis of the GnRH-green fluorescent protein (GFP) transgenic animals.",
"founders were found to be transgenic for GFP.",
"GFP expression was detected in a wide range... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23480392",
"http://www.ncbi.nlm.nih.gov/pubmed/21708138",
"http://www.ncbi.nlm.nih.gov/pubmed/22497513",
"http://www.ncbi.nlm.nih.gov/pubmed/24312079",
"http://www.ncbi.nlm.nih.gov/pubmed/20378924",
"http://www.ncbi.nlm.nih.gov/pubmed/21248708",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019076",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D030781",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000818",
"http://www.nlm.nih.gov/cgi/mesh/2... |
52b2f0d84003448f55000009 | yesno | Is the Snord116 cluster associated with the Prader-Willi syndrome? | [
"Yes, SNORD116 has a major role in Prader-Willi syndrome etiology."
] | [
"yes"
] | [
"All three deletions included SNORD116, but only two encompassed parts of SNURF-SNRPN, implicating SNORD116 as the major contributor to the Prader-Willi phenotype. Our case adds further information about genotype-phenotype correlation and supports the hypothesis that SNORD116 plays a major role in the pathogenesis ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24311433",
"http://www.ncbi.nlm.nih.gov/pubmed/18320030",
"http://www.ncbi.nlm.nih.gov/pubmed/22694955",
"http://www.ncbi.nlm.nih.gov/pubmed/21977908",
"http://www.ncbi.nlm.nih.gov/pubmed/22237428",
"http://www.ncbi.nlm.nih.gov/pubmed/22495932",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#notation",
"s": "http://linkedlifedata.com/resource/umls/label/A11940272",
"o": "605436"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A17465421",
"o": "SNORD116-1"
},
{
"... | [
"http://www.disease-ontology.org/api/metadata/DOID:11983",
"http://www.disease-ontology.org/api/metadata/DOID:225",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011218"
] |
56c1f00cef6e39474100003e | factoid | Aleglitazar is agonist of which receptor? | [
"Aleglitazar is a balanced peroxisome proliferator-activated receptor-α/γ agonist."
] | [
"peroxisome proliferator-activated receptor-α/γ"
] | [
"Effects of the dual peroxisome proliferator-activated receptor activator aleglitazar in patients with Type 2 Diabetes mellitus or prediabetes.",
"Aleglitazar is a dual peroxisome proliferator-activated receptor α/γ agonist with favorable insulin-sensitizing and glucose-lowering actions, favorable effects on bloo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22244809",
"http://www.ncbi.nlm.nih.gov/pubmed/19515415",
"http://www.ncbi.nlm.nih.gov/pubmed/22113345",
"http://www.ncbi.nlm.nih.gov/pubmed/21114416",
"http://www.ncbi.nlm.nih.gov/pubmed/21251281",
"http://www.ncbi.nlm.nih.gov/pubmed/20837369",
"http://www.ncbi.nlm.n... | [] | [] |
54d8e319014675820d000009 | summary | What are the main characteristics of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)? | [
"Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic cardiac disorder characterized by life-threatening arrhythmias induced by physical or emotional stress, in the absence structural heart abnormalities. The phenotype of CPVT is characterized by polymorphic ventricular arrhyt... | [] | [
"Catecholaminergic polymorphic ventricular tachycardia is a malignant disease, due to mutations in proteins controlling Ca(2+) homeostasis",
"the phenotype is characterized by polymorphic ventricular arrhythmias under stress",
"Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited heart r... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22119737",
"http://www.ncbi.nlm.nih.gov/pubmed/25092222",
"http://www.ncbi.nlm.nih.gov/pubmed/20517833",
"http://www.ncbi.nlm.nih.gov/pubmed/22987135",
"http://www.ncbi.nlm.nih.gov/pubmed/25440180",
"http://www.ncbi.nlm.nih.gov/pubmed/24025405",
"http://www.ncbi.nlm.n... | [] | [] |
53380000d6d3ac6a34000059 | yesno | Is poly (ADP- ribosylation) involved in transcriptional control? | [
"Yes, poly (ADP- ribosylation) plays a role in the maintenance of transcriptional fidelity."
] | [
"yes"
] | [
"Histone phosphorylation, ubiquitylation, SUMOylation and poly-ADP-ribosylation, as well as ATP-dependent nucleosome remodeling complexes, play equally pivotal roles in the maintenance of transcriptional fidelity",
"oly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30) is an abundant nuclear protein that is involved... | [
"http://www.ncbi.nlm.nih.gov/pubmed/1828533",
"http://www.ncbi.nlm.nih.gov/pubmed/9790974",
"http://www.ncbi.nlm.nih.gov/pubmed/18396434",
"http://www.ncbi.nlm.nih.gov/pubmed/17158748",
"http://www.ncbi.nlm.nih.gov/pubmed/17286852",
"http://www.ncbi.nlm.nih.gov/pubmed/18851700"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020727",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070212"
] |
51490275d24251bc0500003d | yesno | Is nimodipine recommended for prevention of vasospasm in aneurysmal subarachnoid hemorrhage patients? | [
"Yes, nimodipine is recommended and FDA approved for prevention of vasospasm after aneurysmal subarachnoid hemorrhage. Multiple studies have demonstrated that nimodipine (administered orally or intravenously) is safe and effective for prevention of vasospasm, and reduce frequency of ischemic complications, lowered ... | [
"yes"
] | [
"This article discusses some of these unresolved issues, including the use of medications such as nimodipine, antifibrinolytics, statins, and magnesium; coiling or clipping for aneurysm securement; and the prevention and treatment of potential complications.",
"The results of this study were as follows: nimodipin... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18847340",
"http://www.ncbi.nlm.nih.gov/pubmed/17029347",
"http://www.ncbi.nlm.nih.gov/pubmed/17705883",
"http://www.ncbi.nlm.nih.gov/pubmed/22543491",
"http://www.ncbi.nlm.nih.gov/pubmed/17479073",
"http://www.ncbi.nlm.nih.gov/pubmed/3521193",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020301",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011322",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013345",
"http://www.disease-ontology.org/a... |
52f348542059c6d71c00000f | summary | what is the role of prostaglandins in cardiac regenaration after myocardial infarction? | [
"Prostaglandins are involved in tissue regeneration after myocardial infarction and inhibitors of prostanoid production, such as aspirin and COX-2 inhibitors, have negative impact in this process. Furthermore, pharmacological interference with prostaglandin synthesis following myocardial infarction is associated wi... | [] | [
"This indicated different cyclooxygenase (COX)-downstream synthases and metabolizing enzymes are involved in the AA products' signaling through the COX-1 and COX-2 pathways. The presence of many enzymes' and receptors' [(COX-1, COX-2, microsomal prostaglandin E synthase (mPGES), cytosolic prostaglandin E synthase (... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8782069",
"http://www.ncbi.nlm.nih.gov/pubmed/20451268",
"http://www.ncbi.nlm.nih.gov/pubmed/21219910"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009203",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011453",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012038"
] |
56c331aa50c68dd416000005 | summary | What is the general function of H3K79 methylation? | [
"ChIP-chip tiling arrays revealed that levels of all degrees of genic H3K79 methylation correlate with mRNA abundance and dynamically respond to changes in gene activity. ",
"ChIP-chip tiling arrays revealed that levels of all degrees of genic H3K79 methylation correlate with mRNA abundance and dynamically respon... | [] | [
"Saccharomyces cerevisiae cells lacking Dot1 exhibit a complete loss of H3K79 methylation and defects in heterochromatin-mediated silencing",
"Furthermore, an acidic patch at the C terminus of Dot1 is required for histone H4 tail binding in vitro, histone H3K79 di- and trimethylation in vivo, and proper telomere ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23382701",
"http://www.ncbi.nlm.nih.gov/pubmed/18003948",
"http://www.ncbi.nlm.nih.gov/pubmed/21724828",
"http://www.ncbi.nlm.nih.gov/pubmed/25464900",
"http://www.ncbi.nlm.nih.gov/pubmed/25079683",
"http://www.ncbi.nlm.nih.gov/pubmed/25417107",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008745",
"http://amigo.geneontology.org/amigo/term/GO:0032259"
] |
515b30d8d24251bc050000b0 | list | Where can we find the protein lacritin? | [
"The protein lacritin can be found in lacrimal and salivary glands as well as in tear fluid and in the thyroid."
] | [
"lacrimal gland",
"salivary glands",
"thyroid",
"tear fluid"
] | [
"Lacritin, a glycoprotein secreted from lacrimal acinar cells,",
"Essential for the viability of the surface epithelium of the eye and for normal vision is the thin, but protein-rich, tear film in which the small tear glycoprotein lacritin appears to play a prominent prosecretory, cytoprotective, and mitogenic ro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22918641",
"http://www.ncbi.nlm.nih.gov/pubmed/23425695",
"http://www.ncbi.nlm.nih.gov/pubmed/16982797",
"http://www.ncbi.nlm.nih.gov/pubmed/22956620",
"http://www.ncbi.nlm.nih.gov/pubmed/19714880",
"http://www.ncbi.nlm.nih.gov/pubmed/17850790",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/LACRT_HUMAN"
] |
54edd9c994afd61504000001 | summary | Where can we find the protein dermcidin? | [
"Dermcidin is a secretes protein found mainly in sweat but it is also found in serum.",
"In previous work we reported the expression of Y-P30 \\/ dermcidin in maternal peripheral blood mononuclear cells and the transport of the protein to the fetal brain. In this study we analyzed hormonal regulation of Y-P30 in ... | [] | [
"In line with the extensive underrepresentation of proteins of the immune system, dermcidin, a sweat-derived AMP, was reduced in its abundance in the skin secretome of ED patients",
"Recently HSP70 has been shown to bind specifically to an N-terminal sequence of a human survival protein (DSEP, Dermcidin). ",
" ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23626547",
"http://www.ncbi.nlm.nih.gov/pubmed/25055737",
"http://www.ncbi.nlm.nih.gov/pubmed/25271322",
"http://www.ncbi.nlm.nih.gov/pubmed/22448321",
"http://www.ncbi.nlm.nih.gov/pubmed/24916439",
"http://www.ncbi.nlm.nih.gov/pubmed/24969620",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D054805",
"http://www.uniprot.org/uniprot/DCD_HUMAN"
] |
532f49f8d6d3ac6a34000035 | list | What is the triple screening test performed during pregnancy measuring? | [
"Alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE3)"
] | [
"AFP",
"Estriol",
"hCG"
] | [
"AFP--1.18 MoM and estriol--1.29 MoM and significantly higher mean median value for the free beta-hCG",
"alpha-fetoprotein (AFP), 1.02 for human chorionic gonadotropin (hCG) and 1.01 for unconjugated estriol (uE3",
"alpha fetoprotein (AFP), beta human chorionic gonadotropin (beta-hCG), and unconjugated estriol ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7522195",
"http://www.ncbi.nlm.nih.gov/pubmed/9333577",
"http://www.ncbi.nlm.nih.gov/pubmed/11925409",
"http://www.ncbi.nlm.nih.gov/pubmed/20120938",
"http://www.ncbi.nlm.nih.gov/pubmed/18817910",
"http://www.ncbi.nlm.nih.gov/pubmed/7688977",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011258"
] |
5150f401d24251bc05000075 | list | What are the generic versions of Viagra? | [
"Generic versions of sildenafil are Elonza, Caverta, Zenegra-100, Vega Asia, Suhagra-100, Vega, Revatio."
] | [
"Elonza",
"Caverta",
"Zenegra-100",
"Vega Asia",
"Suhagra-100",
"Vega"
] | [
"The authors conducted a 12-week case series to study the efficacy and safety of Elonza (generic sildenafil) in PAH patients."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/21054594",
"http://www.ncbi.nlm.nih.gov/pubmed/22386826",
"http://www.ncbi.nlm.nih.gov/pubmed/22925379",
"http://www.ncbi.nlm.nih.gov/pubmed/21591526",
"http://www.ncbi.nlm.nih.gov/pubmed/20338870",
"http://www.ncbi.nlm.nih.gov/pubmed/21324833",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016568",
"http://www.biosemantics.org/jochem#4266960"
] |
56caea805795f9a73e00002c | factoid | Which protein interacts with the Ragulator-RAG GTPases to control mTOR activity? | [
"Extensive functional proteomic analysis established SLC38A9 as an integral part of the Ragulator-RAG GTPases machinery that controls the activation of mTOR.",
"SLC38A9 localizes with Rag-Ragulator complex components on lysosomes and associates with Rag GTPases in an amino acid-sensitive and nucleotide binding st... | [
"Amino Acid-DepeLysosomal Membrane Protein SLC38A9"
] | [
"Together, the findings of our study reveal SLC38A9 as a Rag-Ragulator complex member transducing amino acid availability to mTORC1 activity.",
"Extensive functional proteomic analysis established SLC38A9 as an integral part of the Ragulator-RAG GTPases machinery. Gain of SLC38A9 function rendered cells resistant... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25561175",
"http://www.ncbi.nlm.nih.gov/pubmed/25567906",
"http://www.ncbi.nlm.nih.gov/pubmed/25963655"
] | [] | [] |
51601071298dcd4e51000038 | list | Against which organisms has reverse vaccinology been used? | [
"Reverse Vaccinology (RV) was first applied to serogroup B Neisseria meningitidis. This work induced further research of other pathogens in the same way: Porphyromonas gingivalis, Streptococcus pneumoniae, Chlamydia pneumoniae, Bacillus anthracis, group B streptococci, Helicobacter pylori and Mycobacterium tubercul... | [
"Neisseria meningitidis (serogroup B)",
"Porphyromonas gingivalis",
"Streptococcus pneumoniae",
"Chlamydia pneumoniae",
"Bacillus anthracis",
"group B streptococci",
"Helicobacter pylori",
"Mycobacterium tuberculosis",
"Theileria parva",
"Brachyspira hyodysenteriae",
"Echinococcus granulosus",
... | [
"The potential of this new approach is illustrated by the use of reverse vaccinology for the development of a vaccine against serogroup B meningococcus",
"The Neisseria meningitidis serogroup B project, the first example of Reverse Vaccinology",
"Reverse vaccinology and vaccines for serogroup B Neisseria mening... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23527566",
"http://www.ncbi.nlm.nih.gov/pubmed/22261504",
"http://www.ncbi.nlm.nih.gov/pubmed/16107075",
"http://www.ncbi.nlm.nih.gov/pubmed/23514126",
"http://www.ncbi.nlm.nih.gov/pubmed/17291333",
"http://www.ncbi.nlm.nih.gov/pubmed/16848907",
"http://www.ncbi.nlm.n... | [] | [] |
56c1f021ef6e394741000048 | factoid | Galassi classification is used for which disorder? | [
"Galassi classification system is used to classify arachnoid cysts."
] | [
"arachnoid cyst"
] | [
" All these patients were divided into three subgroups according to Galassi classification. ",
"We are led to conclude that Fenestration is suitable for cysts of types I and II (Galassi classification), cysto-peritoneal shunting is better for cysts of type III.",
"According to Galassi classification they were s... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16096939",
"http://www.ncbi.nlm.nih.gov/pubmed/14676729",
"http://www.ncbi.nlm.nih.gov/pubmed/12922037",
"http://www.ncbi.nlm.nih.gov/pubmed/10663819",
"http://www.ncbi.nlm.nih.gov/pubmed/18704305",
"http://www.ncbi.nlm.nih.gov/pubmed/23696293",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002965"
] |
56c1f027ef6e394741000049 | summary | Describe Mozart effect. | [
"The Mozart effect implies the enhancement of reasoning skills solving spatial problems in normal subjects after listening to Mozart's piano sonata K 448."
] | [] | [
"OBJECTIVE: Listening to Mozart K.448 has been demonstrated to improve spatial task scores, leading to what is known as the Mozart Effect.",
"According to the first publication in 1993 by Rauscher et al. [Nature 1993;365:611], the Mozart effect implies the enhancement of reasoning skills solving spatial problems ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25383198",
"http://www.ncbi.nlm.nih.gov/pubmed/21689988",
"http://www.ncbi.nlm.nih.gov/pubmed/23154636",
"http://www.ncbi.nlm.nih.gov/pubmed/12509211",
"http://www.ncbi.nlm.nih.gov/pubmed/23304207",
"http://www.ncbi.nlm.nih.gov/pubmed/11437309",
"http://www.ncbi.nlm.n... | [] | [] |
56bcd422d36b5da378000005 | summary | What is the purpose of the Tokuhashi scoring system? | [
"Tokuhashi scoring system was developed to predict life expectancy of patients with spinal metastases. The revised Tokuhashi score has been widely used to evaluate indications for surgery and predict survival in patients with metastatic spinal disease."
] | [] | [
" Those referring to representative scoring systems about predicting the survival of patients with metastatic spine tumors were used. The significance and limits of these scoring systems, and the future perspectives were described. Tokuhashi score, Tomita score, Baur score, Linden score, Rades score, and Katagiri s... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24212518",
"http://www.ncbi.nlm.nih.gov/pubmed/17593839",
"http://www.ncbi.nlm.nih.gov/pubmed/23328875",
"http://www.ncbi.nlm.nih.gov/pubmed/21223698",
"http://www.ncbi.nlm.nih.gov/pubmed/21772622",
"http://www.ncbi.nlm.nih.gov/pubmed/21796024",
"http://www.ncbi.nlm.n... | [] | [] |
515993f3d24251bc050000a0 | list | Which compounds exist that are thyroid hormone analogs? | [
"Compoounds such as 3,5-diiodo-L-thyronine, T2, GC-24, CO23, DITPA, 3,5-diiodothyropropionic acid, GC-1, Tetrac, 3,3',5,5'-tetraiodo-thyroacetic acid, KB- 2115, KB - 141, thyronamines, T4-agarose, CGS 23425, D-T3, 3,3',5-triiodo-D-thyronine, 3,5-T2, 3,5-diiodo-L-thyronine, DIT, 3,5-diiodo-L-tyrosine, MIT, 3-monoiod... | [
"3,5-diiodo-L-thyronine",
"T2",
"GC-24",
"CO23",
"DITPA",
"3,5-diiodothyropropionic acid",
"GC-1",
"Tetrac",
"3,3',5,5'-tetraiodo-thyroacetic acid",
"KB-2115",
"KB-141",
"thyronamines",
"T4-agarose",
"CGS 23425",
"D-T3",
"3,3',5-triiodo-D-thyronine",
"3,5-T2",
"3,5-diiodo-L-thyroni... | [
"naturally occurring iodothyronine, 3,5-diiodo-L-thyronine (T2)",
"thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23",
"two thyroid hormone agonists, the TRβ-selective GC-24 and the TRα-selective CO23",
"Diiodothyropropionic acid (DITPA) and GC-1, a noniodinated thyroid hormone analog,",
... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18954857",
"http://www.ncbi.nlm.nih.gov/pubmed/3756504",
"http://www.ncbi.nlm.nih.gov/pubmed/6327972",
"http://www.ncbi.nlm.nih.gov/pubmed/19074582",
"http://www.ncbi.nlm.nih.gov/pubmed/17164749",
"http://www.ncbi.nlm.nih.gov/pubmed/3359982",
"http://www.ncbi.nlm.nih.... | [] | [] |
56c1f002ef6e394741000038 | yesno | Is lenvatinib effective for thyroid cancer? | [
"Yes, lenvatinib is effective for thyroid cancer."
] | [
"yes"
] | [
"New insights in the treatment of radioiodine refractory differentiated thyroid carcinomas: to lenvatinib and beyond.",
"However, even more impressive responses and progression-free survival benefits were seen in the phase III SELECT trial with lenvatinib, giving even higher hopes for the future management of wha... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25974026",
"http://www.ncbi.nlm.nih.gov/pubmed/26105190",
"http://www.ncbi.nlm.nih.gov/pubmed/26316818",
"http://www.ncbi.nlm.nih.gov/pubmed/25553081",
"http://www.ncbi.nlm.nih.gov/pubmed/25671254",
"http://www.ncbi.nlm.nih.gov/pubmed/25913680"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:3963",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013964",
"http://www.disease-ontology.org/api/metadata/DOID:1781"
] |
53357c98d6d3ac6a3400004a | list | What genes are related to breast cancer? | [
"Breast cancer is a disease in which certain cells in the breast become abnormal and multiply without control or order to form a tumor. The most common form of breast cancer begins in cells lining the ducts that carry milk to the nipple (ductal cancer). Other forms of breast cancer begin in the glands that produce ... | [
"p53",
"TP53",
"BRCA2",
"NRF2",
"BRCA1",
"BRCT",
"HER2",
"ERBB2",
"RPS2",
"TOP2A",
"TRIM22"
] | [
"Network analysis showed increased expression of a majority of components in p53 and BRCA1 subnetworks in AA breast tumor samples, and members of the aurora B and polo-like kinase signaling pathways were also highly expressed",
"These results indicate that nuclear NRF2 protein plays important roles in the prolife... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24327800",
"http://www.ncbi.nlm.nih.gov/pubmed/21123097",
"http://www.ncbi.nlm.nih.gov/pubmed/24289229",
"http://www.ncbi.nlm.nih.gov/pubmed/23678008",
"http://www.ncbi.nlm.nih.gov/pubmed/23358415",
"http://www.ncbi.nlm.nih.gov/pubmed/24272208",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/BIN2_HUMAN",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005796",
"http://www.disease-ontology.org/api/metadata/DOID:1612",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001943",
"http://www.disease-o... |
52bf1d9e03868f1b06000010 | factoid | To the ligand of which receptors does Denosumab (Prolia) bind? | [
"Denosumab is a monoclonal antibody against the RANKL"
] | [
"RANKL"
] | [
"Whether the factor has the same role in humans is of clinical interest because an inhibitor for RANKL, denosumab, is already used for the treatment of bone disease and might benefit breast cancer patients.",
"Treatment of AML cells with the clinically available RANKL Ab Denosumab resulted in enhanced NK cell ant... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23616122",
"http://www.ncbi.nlm.nih.gov/pubmed/23241893",
"http://www.ncbi.nlm.nih.gov/pubmed/19098925",
"http://www.ncbi.nlm.nih.gov/pubmed/22815185",
"http://www.ncbi.nlm.nih.gov/pubmed/22338309",
"http://www.ncbi.nlm.nih.gov/pubmed/23139212",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#note",
"s": "http://linkedlifedata.com/resource/umls/label/A9373021",
"o": "MeSH"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1690432",
"o": "http://linkedlifedata.com/resource/umls/... | [
"http://www.biosemantics.org/jochem#4268082",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900120",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030547",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900121",
"http://amigo.geneontology.org/cgi... |
5523e47f7b523f2123000004 | list | List fluorescent reporter proteins. | [
"Fluorescent and luminescent reporter genes have become popular tools for the real-time monitoring of gene expression in living cells:\ngreen fluorescent protein\nTimer\nred fluorescent protein\nyellow fluorescent protein\nbeta-phycoerythrin\ncoral fluorescent reporter protein\nenhanced green fluorescent reporter p... | [
"green fluorescent protein",
"Gfp",
"Timer",
"DsRed1-E5",
"red fluorescent protein",
"dsRed",
"yellow fluorescent protein",
"beta-phycoerythrin",
"coral fluorescent reporter protein",
"enhanced green fluorescent reporter protein",
"mCherry"
] | [
"Fluorescent Timer, or DsRed1-E5, is a mutant of the red fluorescent protein, dsRed, in which fluorescence shifts over time from green to red as the protein matures.",
"green fluorescent protein (Gfp)",
"Characterization of flavin-based fluorescent proteins: an emerging class of fluorescent reporters.",
"Flav... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23741385",
"http://www.ncbi.nlm.nih.gov/pubmed/18566430",
"http://www.ncbi.nlm.nih.gov/pubmed/18501461",
"http://www.ncbi.nlm.nih.gov/pubmed/15258449",
"http://www.ncbi.nlm.nih.gov/pubmed/16468989",
"http://www.ncbi.nlm.nih.gov/pubmed/20532610",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017930",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D061848",
"http://www.uniprot.org/uniprot/GFP_AEQVI",
"http://www.uniprot.org/uniprot/LUXY_VIBFI",
"http://www.nlm.nih.gov/cgi/mesh/20... |
5549de44f35db7552600000c | summary | By which mechanism MutT proteins act against DNA lesions in bacteria? | [
"MutT proteins belong to a class of Nudix hydrolases. The common substrate structure for the proteins of the functionally diverse Nudix superfamily is nucleotide-diphosphate-X, where X is a large variety of leaving groups. The activities of Nudix hydrolases usually result in the release of an inorganic phosphate io... | [] | [
"in addition to the well-characterized hydrolysis of 8-oxo-dGTP at the α-β position, MutT cleaves at the β-γ phosphate bond at a rate of 3% of that recorded for hydrolysis at the α-β position",
"MutT also catalyzes the hydrolysis of 5-methyl-dCTP",
"The common substrate structure for the functionally diverse Nu... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23354752",
"http://www.ncbi.nlm.nih.gov/pubmed/22556419",
"http://www.ncbi.nlm.nih.gov/pubmed/9328176",
"http://www.ncbi.nlm.nih.gov/pubmed/23463507",
"http://www.ncbi.nlm.nih.gov/pubmed/25294823",
"http://www.ncbi.nlm.nih.gov/pubmed/11856756",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.uniprot.org/uniprot/MUTT_PROVU"
] |
56c0968def6e394741000026 | yesno | Was tamoxifen tested for treatment of glioma patients? | [
"Yes, tamoxifen was tested for glioma treatment. However, clinical efficacy of tamoxifen in glioma patients remains unclear and should be tested in further studies."
] | [
"yes"
] | [
"Tamoxifen might have a role in the initial treatment of high-grade gliomas and should be studied in future Phase II trials building on the newly established platform of concurrent chemoradiotherapy.",
"The addition of high-dose tamoxifen to standard radiotherapy does not improve the survival of patients with dif... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9773800",
"http://www.ncbi.nlm.nih.gov/pubmed/16710748",
"http://www.ncbi.nlm.nih.gov/pubmed/10715294",
"http://www.ncbi.nlm.nih.gov/pubmed/9815790",
"http://www.ncbi.nlm.nih.gov/pubmed/12712458",
"http://www.ncbi.nlm.nih.gov/pubmed/15022287",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013629",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005910",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013812"
] |
54fb5720d176fff445000002 | list | Which transcription factors are known as the four (4) "Yamanaka factors" that have been used to create induced pluripotent stem cells (iPSCs)? | [
"Fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSCs) by the application of Yamanaka factors (OSKM). In particular, the mechanisms how the Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc) directly drive reprogramming and which additional components are involved are still not yet understood.",
... | [
"Oct4",
"Oct 3/4",
"Sox2",
"Klf4",
"c-Myc"
] | [
"The recently established reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by Takahashi and Yamanaka represents a valuable tool for future therapeutic applications.",
"In particular, the mechanisms how the Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc) directly drive reprogramming and wh... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21839145",
"http://www.ncbi.nlm.nih.gov/pubmed/23149977",
"http://www.ncbi.nlm.nih.gov/pubmed/23704989",
"http://www.ncbi.nlm.nih.gov/pubmed/23272148",
"http://www.ncbi.nlm.nih.gov/pubmed/23266889",
"http://www.ncbi.nlm.nih.gov/pubmed/24706886",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D057026",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D039904"
] |
514cd15ad24251bc05000067 | summary | What is the role of anhedonia in coronary disease patients? | [
"Anhedonia is associated with poor prognosis in patients with coronary disease. Namely, in patients with coronary disease, anhedonia was associated with increased mortality, greater risk for major cardiac event, impaired physical health status, more cardiac symptoms, more feelings of disability. These associations ... | [] | [
"Reduced positive affect and depression/anxiety were associated with poor prognosis, but reduced positive affect was the only independent predictor of events. The incidence of death/MI in adequate versus reduced positive affect patients was 4% (29/663) vs. 11% (23/211); HR = 2.55 (95% CI 1.46-4.34, P = 0.001), adju... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20439829",
"http://www.ncbi.nlm.nih.gov/pubmed/19430927",
"http://www.ncbi.nlm.nih.gov/pubmed/18069998",
"http://www.ncbi.nlm.nih.gov/pubmed/20105694",
"http://www.ncbi.nlm.nih.gov/pubmed/19932820",
"http://www.ncbi.nlm.nih.gov/pubmed/21082266",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D059445",
"http://www.disease-ontology.org/api/metadata/DOID:3393",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003327",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Ex... |
55033064e9bde69634000036 | summary | What is the clinical value of naltrexone in Parkinson's disease patients? | [
"Naltrexone does not improve clinical features, including motor function, in Parkinson's disease patients. Naltrexone was shown to be effective for treatment of pathological gambling in Parkinson's disease patients."
] | [] | [
"Opioid antagonist naltrexone for the treatment of pathological gambling in Parkinson disease.",
"These patients responded poorly to serotonin reuptake inhibitors, whereas treatment with opioid antagonist naltrexone resulted in the remission of PG.",
"CONCLUSIONS: The opioid antagonist naltrexone could be an ef... | [
"http://www.ncbi.nlm.nih.gov/pubmed/152622",
"http://www.ncbi.nlm.nih.gov/pubmed/11254789",
"http://www.ncbi.nlm.nih.gov/pubmed/22426027",
"http://www.ncbi.nlm.nih.gov/pubmed/7969211",
"http://www.ncbi.nlm.nih.gov/pubmed/23634190",
"http://www.ncbi.nlm.nih.gov/pubmed/25037206"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:14330",
"http://www.biosemantics.org/jochem#4249647"
] |
5541297f182542114d000001 | summary | What is the efficacy of oxaliplatin monotherapy in the management of colorectal cancer? | [
"Oxaliplatin is a promising treatment option for patients with metastatic colorectal cancer. It appears to be particularly advantageous (in terms of response rate and duration of progression-free survival) when used in combination with fluorouracil/calcium folinate as both a first- and second-line option, although ... | [] | [
" Oxaliplatin, a platinum compound, has been commonly used around the world for treating advanced colorectal cancer",
"The oxaliplatin monotherapy dose schedule of 130 mg/m(2) every 3 weeks, recommended worldwide, is acceptable for Japanese patients",
"oxaliplatin is a promising treatment option for patients wi... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9704726",
"http://www.ncbi.nlm.nih.gov/pubmed/16702162",
"http://www.ncbi.nlm.nih.gov/pubmed/15879624",
"http://www.ncbi.nlm.nih.gov/pubmed/10408744",
"http://www.ncbi.nlm.nih.gov/pubmed/18094427"
] | [] | [
"http://www.biosemantics.org/jochem#4278407",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015179",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003123",
"http://www.disease-ontology.org/api/metadata/DOID:9256"
] |
532f0ca1d6d3ac6a3400002f | yesno | Are there any animal models for Niemann-Pick C1 disease? | [
"Yes, murine models of Niemann-Pick type C disease (NPC) exist. They are either homozygous or heterozygous NPC1-deficient [NPC1 (-/-)]/ [NPC1 (+/-)] mouse models."
] | [
"yes"
] | [
"Several animal models were used to analyze the impaired pathways. ",
"We investigated components of the surfactant system in both NPC1 mutant mice and felines and in NPC2 mutant mice near the end of their expected life span. ",
"Thus far, studies of NPC mice have been performed mainly to study the brain and ne... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24044630",
"http://www.ncbi.nlm.nih.gov/pubmed/22325094",
"http://www.ncbi.nlm.nih.gov/pubmed/19875890",
"http://www.ncbi.nlm.nih.gov/pubmed/20864542",
"http://www.ncbi.nlm.nih.gov/pubmed/22404083",
"http://www.ncbi.nlm.nih.gov/pubmed/12297829",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/NPC1_HUMAN",
"http://www.disease-ontology.org/api/metadata/DOID:4",
"http://www.disease-ontology.org/api/metadata/DOID:14504",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004195",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&ex... |
56fcf1b8cf1c325851000005 | factoid | Which type of genes are modulated by SATB1? | [
"Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and functi... | [
"it supresses cell cytokines and differentiation genes"
] | [
"Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation",
"SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of T(reg) cells",
"Foxp3, acting as a tr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15371550",
"http://www.ncbi.nlm.nih.gov/pubmed/16034473",
"http://www.ncbi.nlm.nih.gov/pubmed/21841785"
] | [] | [
"http://www.uniprot.org/uniprot/SATB1_HUMAN",
"http://www.uniprot.org/uniprot/SATB1_MOUSE"
] |
51542eacd24251bc05000084 | yesno | Does HER2 under-expression lead to favorable response to trastuzumab? | [
"No, trastuzumab is effective only in cancers where Her2 is over-expessed."
] | [
"no"
] | [
"over-expression of HER2 is reported in approximately 20% of gastric tumours, challenging the use of targeted therapies. ",
"In patients with advanced gastric or gastro-oesophageal junction cancer, addition of trastuzumab to chemotherapy significantly improved overall survival compared with chemotherapy alone. Ad... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22711713",
"http://www.ncbi.nlm.nih.gov/pubmed/20392785",
"http://www.ncbi.nlm.nih.gov/pubmed/23082154",
"http://www.ncbi.nlm.nih.gov/pubmed/11148461",
"http://www.ncbi.nlm.nih.gov/pubmed/19606230",
"http://www.ncbi.nlm.nih.gov/pubmed/12503030",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00072",
"o": "Trastuzumab"
},
{
"p": "http://linkedlifedata.com/resource/umls/altMetaMap",
"s": "http://linkedlifedata.com/resource/umls/id/C0728747",
"o": "http://linkedl... | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015870",
"http://www.disease-ontology.org/api/metadata/DOID:0060079",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020869",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=00... |
5363bad27d100faa0900000e | list | Which are the most abundant human lincRNA? | [
"MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) locus is misregulated in many human cancers and produces an abundant long nuclear-retained noncoding RNA. MALAT/NEAT2 highly abundant, its expression is strongly regulated in many tumor entities including lung adenocarcinoma and hepatocellular carcino... | [
"MALAT1",
"MALAT-1",
"NEAT2",
"NEAT1",
"H19",
"XIST"
] | [
"One abundant such RNA, ci-ankrd52, largely accumulates to its sites of transcription, associates with elongation Pol II machinery, and acts as a positive regulator of Pol II transcription",
"long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), also known as MALAT-1 or NEAT2 (nuclea... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20459797",
"http://www.ncbi.nlm.nih.gov/pubmed/22840402",
"http://www.ncbi.nlm.nih.gov/pubmed/22718948",
"http://www.ncbi.nlm.nih.gov/pubmed/17270048",
"http://www.ncbi.nlm.nih.gov/pubmed/12490325",
"http://www.ncbi.nlm.nih.gov/pubmed/22840393",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062085"
] |
56d2adc5f22319765a000005 | summary | Which is the molecular function of the protein CCDC40? | [
"The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation and mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms."
] | [] | [
"Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, autosomal recessive disorder that results from functional and ultrastructural abnormalities of motile cilia.",
"Primary ciliary dyskinesia (PCD) is a rare genetic disorder leading to recurrent respiratory tract infections.",
"Ciliary beat pattern... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22499950",
"http://www.ncbi.nlm.nih.gov/pubmed/25493340",
"http://www.ncbi.nlm.nih.gov/pubmed/23234452",
"http://www.ncbi.nlm.nih.gov/pubmed/23402890",
"http://www.ncbi.nlm.nih.gov/pubmed/22693285",
"http://www.ncbi.nlm.nih.gov/pubmed/25802884",
"http://www.ncbi.nlm.n... | [] | [] |
52ffb5d12059c6d71c00007c | yesno | Is the PTPN22 gene a biomarker for rheumatoid arthritis? | [
"Most association studies have indeed confirmed an association between mutations at the PTPN22 gene and rheumatoid arthritis"
] | [
"yes"
] | [
"TPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) confers the highest risk of rheumatoid arthritis among non-HLA genetic variations that are kno... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21607711",
"http://www.ncbi.nlm.nih.gov/pubmed/21542789",
"http://www.ncbi.nlm.nih.gov/pubmed/19324521",
"http://www.ncbi.nlm.nih.gov/pubmed/19445664",
"http://www.ncbi.nlm.nih.gov/pubmed/20498205",
"http://www.ncbi.nlm.nih.gov/pubmed/20398001",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001172"
] |
5314d0e4dae131f84700000e | yesno | Can administration of the thyrotropin releasing hormone reduce fatigue in cancer patients? | [
"yes, in cancer patients, thyrotropin releasing hormone (TRH) administration was associated with significant improvement in cancer related fatigue levels as measured by the Visual Analog Scale-Energy, fatigue and vigor subscales of the POMS, and the fatigue subscale of FACIT-F. TRH administration was safe and toler... | [
"yes"
] | [
"TRH administration was associated with significant improvement (p < 0.05) in fatigue levels as measured by the Visual Analog Scale-Energy (VAS-E), was associated with significant (p < 0.05) improvement in sleep disturbances and improved quality of life. ",
"This decrease in CRP level with TRH administration was ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21947558",
"http://www.ncbi.nlm.nih.gov/pubmed/23387883",
"http://www.ncbi.nlm.nih.gov/pubmed/19761698"
] | [] | [
"http://www.uniprot.org/uniprot/TRH_NOTVI",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013973",
"http://www.uniprot.org/uniprot/TRHA_XENLA",
"http://www.uniprot.org/uniprot/TRH_BOMOR",
"http://www.disease-ontology.org/api/metadata/DOID:162",
"http://www.uniprot.org/... |
51716fd38ed59a060a00000c | summary | What is the role of chromomethylases in plants? | [
"Chromomethylases (CMTs), which constitute a plant-specific DNA (cytosine-5)-methyltransferase family, are involved primarily in the maintenance of symmetrical CpNpG (N = A, T, C, or G) methylation and they also play a role in de novo methylation. CMTs are characterized by the presence of a chromatin-associated dom... | [] | [
"Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants.",
"CHG methylation by CHROMOMETHYLASE3 (CMT3) depends on histone H3K9 dimethylation (H3K9me2), but the mechanism underlying this relationship is poorly understood. Here, we report multiple lines of eviden... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22058406",
"http://www.ncbi.nlm.nih.gov/pubmed/11487702",
"http://www.ncbi.nlm.nih.gov/pubmed/20505370",
"http://www.ncbi.nlm.nih.gov/pubmed/17660570",
"http://www.ncbi.nlm.nih.gov/pubmed/11459824",
"http://www.ncbi.nlm.nih.gov/pubmed/23021223",
"http://www.ncbi.nlm.n... | [
{
"p": "http://purl.uniprot.org/core/fullName",
"s": "http://linkedlifedata.com/resource/#_4F3634393937006",
"o": "Chromomethylase"
},
{
"p": "http://purl.uniprot.org/core/fullName",
"s": "http://linkedlifedata.com/resource/#_423147594832004",
"o": "Chromomethylase"
}
] | [
"http://www.uniprot.org/uniprot/CMT3_ARATH",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010944",
"http://www.uniprot.org/uniprot/CMT2_ARATH"
] |
56b0eb3b0a360a5e45000019 | yesno | Is curcumin a phytochemical? | [
"Yes, curcumin is a phytochemical derived from rhizome of turmeric Curcuma longa."
] | [
"yes"
] | [
"we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals",
"The phytochemical, curcumin, has been reported to play many beneficial roles.",
"Curcumin (CUR), the major component in Curcuma longa, has been shown as a potent chem... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25272063",
"http://www.ncbi.nlm.nih.gov/pubmed/25640947",
"http://www.ncbi.nlm.nih.gov/pubmed/26155681",
"http://www.ncbi.nlm.nih.gov/pubmed/25543853",
"http://www.ncbi.nlm.nih.gov/pubmed/25149981",
"http://www.ncbi.nlm.nih.gov/pubmed/24815764",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#note",
"s": "http://linkedlifedata.com/resource/umls/label/A2792113",
"o": "MeSH"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A2792113",
"o": "curcumin III"
},
{
"p": "h... | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003474",
"http://www.biosemantics.org/jochem#4272467",
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D064209"
] |
571f2e8e0fd6f91b68000001 | summary | What is Cerebral Cavernous Malformation? | [
"Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vascular malformations and very severe neurological consequences",
"Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vas... | [] | [
"Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vascular malformations and very severe neurological consequences",
"Cerebral cavernous malformations (CMs) are vascular malformations of the central nervous system, which can be detected in th... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12140362",
"http://www.ncbi.nlm.nih.gov/pubmed/21543988",
"http://www.ncbi.nlm.nih.gov/pubmed/10235015",
"http://www.ncbi.nlm.nih.gov/pubmed/26523262",
"http://www.ncbi.nlm.nih.gov/pubmed/24401931",
"http://www.ncbi.nlm.nih.gov/pubmed/26109568",
"http://www.ncbi.nlm.n... | [] | [] |
54ede5c394afd61504000006 | yesno | Is Fanconi anemia presented as a genetically and clinically heterogeneous disease entity? | [
"Fanconi anemia (FA), an autosomal recessive disorder characterized by a progressive pancytopenia associated with congenital anomalies and high predisposition to malignancies, is a genetically and clinically heterogeneous disease. At least eight complementation groups (FA-A to FA-H) have been identified ",
"Fanc... | [
"yes"
] | [
"Fanconi anaemia (FA) is a rare, autosomal recessive, genetically complex, DNA repair deficiency syndrome in man. Patients with FA exhibit a heterogeneous spectrum of clinical features. The most significant and consistent phenotypic characteristics are stem cell loss, causing progressive bone marrow failure and ste... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21956823",
"http://www.ncbi.nlm.nih.gov/pubmed/12955722",
"http://www.ncbi.nlm.nih.gov/pubmed/9521584",
"http://www.ncbi.nlm.nih.gov/pubmed/10090479",
"http://www.ncbi.nlm.nih.gov/pubmed/12552564",
"http://www.ncbi.nlm.nih.gov/pubmed/23146055",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051856",
"http://www.disease-ontology.org/api/metadata/DOID:13636",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005199",
"http://www.disease-ontology.org/api/metadata/DOID:1062"
] |
517545168ed59a060a00002b | summary | What is the treatment of interferon-induced thyroiditis? | [
"An altered thyroid function is frequently observed during interferon treatment with a pattern similar to Hashimoto Thyroiditis or Graves disease.\nVery frequently the alterations of thyroid hormones related to interferon-induced thyroiditis spontaneosly diseapper in a few months\nTreatment when necessary is propa... | [] | [] | [
"http://www.ncbi.nlm.nih.gov/pubmed/22148004",
"http://www.ncbi.nlm.nih.gov/pubmed/19054259",
"http://www.ncbi.nlm.nih.gov/pubmed/21214950"
] | [] | [] |
56cafa845795f9a73e00002e | factoid | Which protein pathway is regulating SGK1-mediated phosphorylation of FOXO3a to control cell proliferation? | [
"mTORC1, in coordination with mTORC2, controls cell proliferation by regulating FoxO3a gene expression and SGK1-mediated phosphorylation of FOXO3a at Ser314."
] | [
"The mTOR pathway"
] | [
"The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase",
"the FoxO3a transcription factor is coordinately regulated by mTORC1 and mTORC2, and plays a crucial role in controlling cell proliferation",
"mTORC1, in coordination with mTORC2, controls cell prolifer... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24558442"
] | [] | [] |
532b15ecd6d3ac6a34000014 | list | Which drugs have been found effective for the treatment of chordoma? | [
"Established chordoma cell lines, and patient-derived primary cell cultures, as well as chordoma tumors in vivo were found to be sensitive to treatment with bortezomib, vincristine, doxorubicin, etoposide, cisplatin, fludarabine and SD-1029 Stat3 inhibitor. Moreover, percutaneous intratumoral injection with pingyan... | [
"bortezomib",
"vincristine",
"doxorubicin",
"etoposide",
"cisplatin",
"fludarabine",
"SD-1029 Stat3 inhibitor",
"pingyangmycin lipiodol emulsion"
] | [
"The combination treatment of bortezomib with topoisomerase I and II inhibitors increased the therapeutic potency in U-CH2 and patient-derived primary cultures.",
"Vincristine, doxorubicin, etoposide, cisplatin, and fludarabine, each at a concentration of 10 μM, decreased the number of chordoma cells when given a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23792643",
"http://www.ncbi.nlm.nih.gov/pubmed/21801998",
"http://www.ncbi.nlm.nih.gov/pubmed/19723879",
"http://www.ncbi.nlm.nih.gov/pubmed/20965848",
"http://www.ncbi.nlm.nih.gov/pubmed/21905773"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013812",
"http://www.disease-ontology.org/api/metadata/DOID:3302",
"http://www.disease-ontology.org/api/metadata/DOID:4153",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016896",
"http://... |
56c830635795f9a73e00000e | list | Which components of the stress granules are known to be related to motor neuron degeneration in Amyotrophic Lateral Sclerosis? | [
"Of note, both ALS and FTD are characterized by pathological inclusions, where some well-known SG markers localize with the ALS related proteins TDP-43 and FUS.",
"TDP-43 and FUS have been identified as key proteins in the pathogenesis of some cases of ALS. Although their role in motor neuron degeneration is not ... | [
"TDP-43",
"FUS"
] | [
"Here, we demonstrate that C-terminal ALS mutations disrupt the nuclear localizing signal (NLS) of FUS resulting in cytoplasmic accumulation in transfected cells and patient fibroblasts. FUS mislocalization is rescued by the addition of the wild-type FUS NLS to mutant proteins. We also show that oxidative stress re... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23474818",
"http://www.ncbi.nlm.nih.gov/pubmed/24804206",
"http://www.ncbi.nlm.nih.gov/pubmed/25429138",
"http://www.ncbi.nlm.nih.gov/pubmed/20699327",
"http://www.ncbi.nlm.nih.gov/pubmed/19338576",
"http://www.ncbi.nlm.nih.gov/pubmed/24090136",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012598",
"http://www.disease-ontology.org/api/metadata/DOID:230",
"http://amigo.geneontology.org/amigo/term/GO:0035617",
"http://amigo.geneontology.org/amigo/term/GO:0034063",
"http://www.disease-ontology.org/api/metadata/DOI... |
56ae71cb0a360a5e45000010 | yesno | Is there evidence for de novo genesis of enhancers in vertebrates? | [
"Yes."
] | [
"yes"
] | [
"De novo genesis of enhancers in vertebrates.",
"Evolutionary innovation relies partially on changes in gene regulation. While a growing body of evidence demonstrates that such innovation is generated by functional changes or translocation of regulatory elements via mobile genetic elements, the de novo generation... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22069375"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014714"
] |
5720a8da0fd6f91b68000010 | list | Which could be some of the possible causes of hypersomnia? | [
"Sleep-wake disturbances (SWD) with hypersomnia are common after traumatic brain injury (TBI), with decreased CSF levels of hypocretin-1, a wake-promoting neurotransmitter, in cases of sleep apnea, as well as in up to half the patients with dementia, particularly in vascular dementia, Korsakow syndrome, Parkinson's... | [
"traumatic brain injury (TBI)",
"sleep apnea",
"dementia"
] | [
"Sleep-wake disturbances (SWD) are common after traumatic brain injury (TBI). In acute TBI, we recently found decreased CSF levels of hypocretin-1, a wake-promoting neurotransmitter",
"Hypocretin levels 6 months after TBI were significantly lower in patients with post-traumatic EDS",
"These results suggest that... | [
"http://www.ncbi.nlm.nih.gov/pubmed/14638887",
"http://www.ncbi.nlm.nih.gov/pubmed/8491310",
"http://www.ncbi.nlm.nih.gov/pubmed/9381026",
"http://www.ncbi.nlm.nih.gov/pubmed/11022396",
"http://www.ncbi.nlm.nih.gov/pubmed/17584779",
"http://www.ncbi.nlm.nih.gov/pubmed/10953647",
"http://www.ncbi.nlm.nih... | [] | [] |
54f5bc7d5f206a0c06000001 | factoid | What is the function of caspases? | [
"Caspases are intracellular proteases that propagate programmed cell death, proliferation, and inflammation."
] | [
"Caspases are intracellular proteases that propagate programmed cell death, proliferation, and inflammation."
] | [
"Caspases are the ultimate executors of the apoptotic programmed cell death pathway.",
"Members of the caspase family of cysteine proteases coordinate the morphological and biochemical events that typify apoptosis. ",
"Caspase function is known to be essential for cell death by apoptosis,",
"Caspases, initial... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12407171",
"http://www.ncbi.nlm.nih.gov/pubmed/18483489",
"http://www.ncbi.nlm.nih.gov/pubmed/16103108",
"http://www.ncbi.nlm.nih.gov/pubmed/9874792",
"http://www.ncbi.nlm.nih.gov/pubmed/22541691",
"http://www.ncbi.nlm.nih.gov/pubmed/12170777",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.uniprot.org/uniprot/ICE_DROME",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020169",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004197",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020170",
"htt... |
551c4ffc6b348bb82c000010 | yesno | Is TNNI3K a cardiac-specific protein? | [
"Yes, TNNI3K is highly expressed in heart but is undetectable in other tissues."
] | [
"yes"
] | [
"cardiomyocyte-specific kinase TNNI3K ",
"We report that cardiac troponin I-interacting kinase (TNNI3K), a cardiomyocyte-specific kinase,",
"TNNI3K, a cardiac-specific kinase, ",
" The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18552163",
"http://www.ncbi.nlm.nih.gov/pubmed/23085512",
"http://www.ncbi.nlm.nih.gov/pubmed/24132636",
"http://www.ncbi.nlm.nih.gov/pubmed/21314842",
"http://www.ncbi.nlm.nih.gov/pubmed/20018082",
"http://www.ncbi.nlm.nih.gov/pubmed/19925440",
"http://www.ncbi.nlm.n... | [] | [] |
5710ed19a5ed216440000003 | summary | How does Rif1 regulate DNA replication? | [
"Rif1 (Rap1-interacting-factor-1), originally identified as a telomere-binding factor in yeast, is a critical determinant of the replication timing programme in human cells. Rif1 tightly binds to nuclear-insoluble structures at late-M-to-early-G1 and regulates chromatin-loop sizes. Furthermore, Rif1 colocalizes spe... | [] | [
"Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity",
"Yeast Rif1 associates with telomeres and regulates their length. In contrast, human Rif1 did not accumulate at functional telomeres, but localized to dysfunctional telomeres and to telomeric DNA clu... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24462468",
"http://www.ncbi.nlm.nih.gov/pubmed/24656819",
"http://www.ncbi.nlm.nih.gov/pubmed/23809990",
"http://www.ncbi.nlm.nih.gov/pubmed/24685139",
"http://www.ncbi.nlm.nih.gov/pubmed/22850673",
"http://www.ncbi.nlm.nih.gov/pubmed/24634216",
"http://www.ncbi.nlm.n... | [] | [] |
51588c1ad24251bc05000094 | yesno | Is factor XI deficient in Hemophilia C? | [
"Factor XI deficiency is associated with a bleeding tendency called Hemophilia C."
] | [
"yes"
] | [
"Factor XI deficiency is a rare hematologic disorder. Hemophilia C (factor XI deficiency) affects both genders and it is usually asymptomatic,",
"Congenital factor XI deficiency (also known as the Rosenthal syndrome or hemophilia C)",
"rare case of an acute cerebral aneurysm rupture in a patient with a known fa... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18378181",
"http://www.ncbi.nlm.nih.gov/pubmed/18160615",
"http://www.ncbi.nlm.nih.gov/pubmed/20485963",
"http://www.ncbi.nlm.nih.gov/pubmed/8277060",
"http://www.ncbi.nlm.nih.gov/pubmed/1546275"
] | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006467",
"http://www.disease-ontology.org/api/metadata/DOID:2229",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005173",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Ex... |
550300fce9bde6963400000a | summary | What is known about food intolerance and gluten ? | [
"Celiac disease, with a prevalence around 1% of the general population, is the most common genetically-induced food intolerance in the world. Triggered by the ingestion of gluten in genetically predisposed individuals.\nEmerging research into a syndrome known as nonceliac gluten sensitivity suggests a heterogeneous... | [] | [
"At present, there is no specific bio-marker of gluten sensitivity.",
"Emerging research into a syndrome known as nonceliac gluten sensitivity suggests a heterogeneous condition with some features of celiac disease but often categorized as FGIDs, including IBS.",
"Celiac disease, with a prevalence around 1% of ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23567359",
"http://www.ncbi.nlm.nih.gov/pubmed/23496382",
"http://www.ncbi.nlm.nih.gov/pubmed/16313685",
"http://www.ncbi.nlm.nih.gov/pubmed/17979710",
"http://www.ncbi.nlm.nih.gov/pubmed/23767452",
"http://www.ncbi.nlm.nih.gov/pubmed/20036949"
] | [] | [] |
551910c5622b194345000007 | yesno | Are EDNRB mutations involved in the development of Hirschsprung disease? | [
"Although mutations in eight different genes (EDNRB, EDN3, ECE1, SOX10, RET, GDNF, NTN, SIP1) have been identified in affected individuals, it is now clear that RET and EDNRB are the primary genes implicated in the etiology of HSCR. Mutations in genes of the RET receptor tyrosine kinase and endothelin receptor B (E... | [
"yes"
] | [
"QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations",
"As reported previously, when the same null mutation of the Ednrb gene, Ednrb(sl), was introgressed into the F344 strain, almost 60% of F344-Ednrb(sl/sl) pups did not show any symptom... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15834508",
"http://www.ncbi.nlm.nih.gov/pubmed/12631670",
"http://www.ncbi.nlm.nih.gov/pubmed/14633923",
"http://www.ncbi.nlm.nih.gov/pubmed/11471546",
"http://www.ncbi.nlm.nih.gov/pubmed/15294878",
"http://www.ncbi.nlm.nih.gov/pubmed/12574515",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:10487",
"http://www.uniprot.org/uniprot/EDNRB_MACFA",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006627",
"http://www.uniprot.org/uniprot/EDNRB_MOUSE"
] |
5502fe13e9bde69634000009 | summary | What is known about the effectiveness of electronic food diaries ? | [
"Electronic dietary records were better than food diaries in terms of fat percentage reduction in our trials, indicating that teledietetics increases healthy-eating awareness."
] | [] | [
"Electronic dietary records were better than food diaries in terms of fat percentage reduction in our trials, indicating that teledietetics increases healthy-eating awareness.",
"Nutrition monitoring is a relevant method to gain an overview of factors influencing health. However, keeping a food diary often consti... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24205807",
"http://www.ncbi.nlm.nih.gov/pubmed/23415822",
"http://www.ncbi.nlm.nih.gov/pubmed/20307404"
] | [] | [] |
5717bacacb4ef8864c00000d | yesno | Can the apoptosis regulator BAX trigger the release of cytochrome c? | [
"Yes, altered Bax conformation trigger its redistribution from the cytosol to mitochondria. Subsequently, cytochrome c is released from mitochondria to cytosol."
] | [
"yes"
] | [
"6-Shogaol reduced the mitochondrial membrane potential (MMP) and released cytochrome c from mitochondria to cytosol via Bax activation. ",
"Moreover, overexpression of ERβ prevented Bax activation, cytochrome c release, caspase-3 activation, and PARP cleavage during apoptosis.",
"In this study, we demonstrated... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25524600",
"http://www.ncbi.nlm.nih.gov/pubmed/25619640",
"http://www.ncbi.nlm.nih.gov/pubmed/22116711",
"http://www.ncbi.nlm.nih.gov/pubmed/21307199",
"http://www.ncbi.nlm.nih.gov/pubmed/23954445",
"http://www.ncbi.nlm.nih.gov/pubmed/23567751",
"http://www.ncbi.nlm.n... | [] | [] |
54fc27a896abe38008000002 | summary | Which biological process in known as Endoplasmic Reticulum-Associated Protein Degradation (ERAD)? | [
"Endoplasmic reticulum-associated protein degradation (ERAD) is the quality control system in the endoplasmic reticulum of eukaryotic cells which ensures that newly synthesized proteins that fail to fold into the correct conformation or unassembled orphan subunits of oligomeric proteins are rapidly eliminated by pr... | [] | [
"Endoplasmic reticulum-associated protein degradation (ERAD) removes improperly-folded proteins from the ER membrane into the cytosol where they undergo proteasomal degradation. ",
"In the secretory pathway, quality control for the correct folding of proteins is largely occurring in the endoplasmic reticulum (ER)... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10906272",
"http://www.ncbi.nlm.nih.gov/pubmed/8943015",
"http://www.ncbi.nlm.nih.gov/pubmed/11139575",
"http://www.ncbi.nlm.nih.gov/pubmed/21135095",
"http://www.ncbi.nlm.nih.gov/pubmed/16573235",
"http://www.ncbi.nlm.nih.gov/pubmed/24817869",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004721",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055694",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005783",
"http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field... |
54d8d60d014675820d000007 | list | List BRAF inhibitors that have been tested in clinical trials for treatment of melanoma patients | [
"Vemurafenib and dabrafenib are BRAF inhibitors that have been tested in clinical trials for treatment of melanoma patients."
] | [
"Vemurafenib",
"Dabrafenib"
] | [
"Combined BRAF (Dabrafenib) and MEK inhibition (Trametinib) in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor.",
" Here, we report patients treated with combination therapy after disease progression with BRAF inhibitor treatment administered before study enrollmen... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24456413",
"http://www.ncbi.nlm.nih.gov/pubmed/21639808",
"http://www.ncbi.nlm.nih.gov/pubmed/23094782",
"http://www.ncbi.nlm.nih.gov/pubmed/23621583",
"http://www.ncbi.nlm.nih.gov/pubmed/24408395",
"http://www.ncbi.nlm.nih.gov/pubmed/22804352",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:1909"
] |
531375a6e3eabad021000011 | list | which are the risk factors for sudden cardiac death in patients with hypertrophic cardiomyopathy? | [
"The following risk factors for sudden cardiac death in patients with hypertrophic cardiomyopathy have been identified: 1) previous cardiac arrest; 2) sustained ventricular tachycardia; 3) family history of sudden cardiac death; 4) high-risk genetic mutations; 5) unexplained syncope; 6) non-sustained ventricular ta... | [
"myocardial fibrosis using late gadolinium enhancement",
"J-wave on ECG",
"Extreme left ventricular hypertrophy (>30mm)",
"Nonsustained ventricular tachycardia",
"Sustained ventricular tachycardia",
"previous cardiac arrest",
"family history of sudden cardiac death",
"unexplained syncope",
"hypotens... | [
"Cardiac magnetic resonance (CMR) is used in the diagnosis and risk stratification of hypertrophic cardiomyopathy (HCM) and can detect myocardial replacement fibrosis (anindependent predictor of adverse cardiac outcomes) using late gadolinium enhancement (LGE). ",
"J wave is associated with increased risk of sudd... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23990187",
"http://www.ncbi.nlm.nih.gov/pubmed/15929624",
"http://www.ncbi.nlm.nih.gov/pubmed/18221594",
"http://www.ncbi.nlm.nih.gov/pubmed/20132378",
"http://www.ncbi.nlm.nih.gov/pubmed/17652294",
"http://www.ncbi.nlm.nih.gov/pubmed/19850699",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016757",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002312",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012307"
] |
5335c938d6d3ac6a34000052 | summary | What is known about the economic cost of urinary incontinence? | [
"The estimated total economic cost in treating overactive bladder was 117 billion Korean Won (KRW, the currency of South Koea) in 2006 and 145 billion KRW in 2007. The estimated total cost in treating stress urinary incontinence was 122 billion KRW in 2006 and 59 billion KRW in 2007.\nThe estimated total economic c... | [] | [
"urgency UI also results in substantial economic costs",
"substantial economic burden attributable to UI due to NDO",
"The estimated total economic cost in treating overactive bladder was 117 billion Korean Won (KRW, the currency of South Koea) in 2006 and 145 billion KRW in 2007. The estimated total cost in tr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12809878",
"http://www.ncbi.nlm.nih.gov/pubmed/11386591",
"http://www.ncbi.nlm.nih.gov/pubmed/24198618",
"http://www.ncbi.nlm.nih.gov/pubmed/11183903",
"http://www.ncbi.nlm.nih.gov/pubmed/22500250",
"http://www.ncbi.nlm.nih.gov/pubmed/23369111",
"http://www.ncbi.nlm.n... | [] | [
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004469",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014549",
"http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017048",
"http://www.nlm.nih.gov/cgi/mesh/2... |
56d1e23c67f0cb3d66000009 | factoid | Which are the coactivators of the Yes-associated protein (yap)? | [
"The Yap protein forms complex with Tead (TEA domain) transcription factors."
] | [
"Tead (TEA domain) transcription factors."
] | [
"ndependent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo pathway regulates the activity of Tead transcription factors mainly through ph... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22632831",
"http://www.ncbi.nlm.nih.gov/pubmed/16332960",
"http://www.ncbi.nlm.nih.gov/pubmed/23380592",
"http://www.ncbi.nlm.nih.gov/pubmed/23985334",
"http://www.ncbi.nlm.nih.gov/pubmed/25097035",
"http://www.ncbi.nlm.nih.gov/pubmed/20439427"
] | [] | [] |
Subsets and Splits
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