id stringlengths 24 24 | type stringclasses 4
values | body stringlengths 13 215 | ideal_answer listlengths 1 12 | exact_answer listlengths 0 44 | snippets listlengths 0 121 | documents listlengths 1 157 | triples listlengths 0 537 | concepts listlengths 0 99 |
|---|---|---|---|---|---|---|---|---|
5891c90949702f2e01000001 | factoid | Which tool employs self organizing maps for analyzing synonymous codon usage? | [
"INteractive Codon usage Analysis (INCA) provides an array of features useful in analysis of synonymous codon usage in whole genomes. In addition to computing codon frequencies and several usage indices, such as 'codon bias', effective Nc and CAI, the primary strength of INCA has numerous options for the interactiv... | [
"INCA"
] | [
"INCA: synonymous codon usage analysis and clustering by means of self-organizing map.",
"INteractive Codon usage Analysis (INCA) provides an array of features useful in analysis of synonymous codon usage in whole genomes. In addition to computing codon frequencies and several usage indices, such as 'codon bias',... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15059815"
] | [] | [] |
587e42032420191125000004 | summary | What is MINDY-1? | [
"MINDY-1 (motif interacting with Ub-containing novel DUB family) is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. Found in all eukaryotes, MINDY-family DUBs are highly selective at cleaving K48-linked polyUb, a signal that targets proteins for degradation.... | [] | [
"MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes",
"Here we report the discovery of a new family of DUBs, which we have named MINDY (motif interacting with Ub-containing novel DUB family). Found in all eukaryotes, MINDY-family DUBs are highly sel... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27292798"
] | [] | [
"http://www.uniprot.org/uniprot/FA63A_MOUSE",
"http://www.uniprot.org/uniprot/FA63A_PONAB",
"http://www.uniprot.org/uniprot/FA63A_BOVIN",
"http://www.uniprot.org/uniprot/FA63A_RAT",
"http://www.uniprot.org/uniprot/FA63A_DANRE",
"http://www.uniprot.org/uniprot/FA63A_HUMAN"
] |
58a5723c60087bc10a00001e | summary | What is the benserazide's mechanism of function when co-administered with L-DOPA in patients with Parkinson's Disease? | [
"Benserazide is a peripheral decarboxylase inhibitor. Benserazide in combination with L-DOPA constitutes a slow-release formulation of L-DOPA in patients with Parkinson's disease (PD), it reduces peaks and rapid fluctuations of L-DOPA plasma levels (possibly responsible for peak-dose dyskinesias and end-of-dose det... | [] | [
"Recent human and animal biochemical investigations clearly confirm and extend previous findings indicating that benserazide is much more potent than carbidopa as peripheral decarboxylase inhibitor. L-DOPA in combination with benserazide or carbidopa constitutes the best available therapy for Parkinson's disease (P... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20303948",
"http://www.ncbi.nlm.nih.gov/pubmed/3768865",
"http://www.ncbi.nlm.nih.gov/pubmed/12703659",
"http://www.ncbi.nlm.nih.gov/pubmed/11166288",
"http://www.ncbi.nlm.nih.gov/pubmed/8584079",
"http://www.ncbi.nlm.nih.gov/pubmed/11587490",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:14330",
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4275540",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010300",
"http://www.biosemantics.org/jochem#4275540"
] |
587e3f4e2420191125000003 | summary | What is regioneR? | [
"Statistically assessing the relation between a set of genomic regions and other genomic features is a common challenging task in genomic and epigenomic analyses. regioneR is an R package that implements a permutation test framework specifically designed to work with genomic regions. In addition to the predefined r... | [] | [
"regioneR: an R/Bioconductor package for the association analysis of genomic regions based on permutation tests",
"regioneR is an R package that implements a permutation test framework specifically designed to work with genomic regions. In addition to the predefined randomization and evaluation strategies, region... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26424858"
] | [] | [] |
58a0da5278275d0c4a000054 | list | For what indications is thalidomide currently marketed? | [
"Drug repositioning, exemplified by sildenafil and thalidomide, is a promising way to explore alternative indications for existing drugs. THE USE OF A DRUG WITH A TEMPORARY MARKETING AUTHORISATION: Thalidomide is currently available in France for nominative or cohort use with a temporary marketing authorisation (TM... | [
"Multiple myeloma",
"polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes",
"POEMS",
"Irritable Bowels Syndrome ",
"IBS"
] | [
"In this retrospective study, pharmacy claims were analyzed for those patients with a diagnosis of MM who received thalidomide, lenalidomide, or pomalidomide from a large specialty pharmacy in the US between January 1, 2011, and December 31, 2013.",
"Polyneuropathy, organomegaly, endocrinopathy, M-protein and ski... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12423428",
"http://www.ncbi.nlm.nih.gov/pubmed/18034532",
"http://www.ncbi.nlm.nih.gov/pubmed/26462773",
"http://www.ncbi.nlm.nih.gov/pubmed/26652728",
"http://www.ncbi.nlm.nih.gov/pubmed/18050580",
"http://www.ncbi.nlm.nih.gov/pubmed/24931258",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056687",
"http://www.biosemantics.org/jochem#4018109",
"http://www.biosemantics.org/jochem#4017077",
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4250023",
"http://www.biosemantics.org/jochem#42500... |
58a3264e60087bc10a00000d | summary | What are reactive metabolites? | [
"Reactive metabolites are generated when a small molecule, commonly a drug or hydrocarbon, is broken down in the body. Reactive metabolites can cause cancer and other diseases as well as hepatoxicty. "
] | [] | [
"The results implicate the cis-enedial reactive metabolite of DIOB was responsible for the observed toxicities. The observed modest depletion of hepatic GSH in DIOB-treated animals suggests the actions of one or more reactive metabolites, and the hepatic injury observed could be due at least in part to reactions of... | [
"http://www.ncbi.nlm.nih.gov/pubmed/159767",
"http://www.ncbi.nlm.nih.gov/pubmed/8987247",
"http://www.ncbi.nlm.nih.gov/pubmed/25363902",
"http://www.ncbi.nlm.nih.gov/pubmed/26627130",
"http://www.ncbi.nlm.nih.gov/pubmed/21469730",
"http://www.ncbi.nlm.nih.gov/pubmed/25851819",
"http://www.ncbi.nlm.nih.... | [] | [] |
589c389278275d0c4a00003e | summary | What is the "wearing-off" phenomenon in levodopa-treated patients with Parkinson's Disease? | [
"Chronic administration of traditional levodopa/dopa decarboxylase inhibitor formulations to Paskinson's Disease patients is associated with the development of complications, such as wearing-off phenomenon. Wearing-off phenomenon is characterized by the predictable emergence of motor symptoms (e.g. rigidity and fre... | [] | [
"It is unlike the \"wearing-off\" phenomenon that occurs when dopaminergic drug levels decline and responds to dopaminergic rescue drugs. ",
"Unfortunately, chronic use of traditional levodopa/dopa decarboxylase inhibitor formulations is associated with the development of complications, such as wearing-off and dy... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25616444",
"http://www.ncbi.nlm.nih.gov/pubmed/16805724",
"http://www.ncbi.nlm.nih.gov/pubmed/14960500",
"http://www.ncbi.nlm.nih.gov/pubmed/15098347",
"http://www.ncbi.nlm.nih.gov/pubmed/10654309",
"http://www.ncbi.nlm.nih.gov/pubmed/11889758",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010300",
"http://www.biosemantics.org/jochem#4222145",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007980",
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:427554... |
58a0f95c78275d0c4a000055 | summary | What are prions? | [
"Prion diseases are protein conformation disorders and neither caused by viroid or virus but is a transmissible particle labeled a prion by Pruisner. Normal prion protein becomes infectious by a different folding, but the triggers are not known. ",
"A prion is an infectious agent composed entirely of protein and ... | [] | [
"Prion diseases are protein conformation disorders and neither caused by viroid or virus but is a transmissible particle labeled a prion by Pruisner. Normal prion protein becomes infectious by a different folding, but the triggers are not known. ",
"Prions are proteins most commonly associated with fatal neurodeg... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26297259",
"http://www.ncbi.nlm.nih.gov/pubmed/27833227",
"http://www.ncbi.nlm.nih.gov/pubmed/22363733",
"http://www.ncbi.nlm.nih.gov/pubmed/25645281",
"http://www.ncbi.nlm.nih.gov/pubmed/27293325",
"http://www.ncbi.nlm.nih.gov/pubmed/24390581"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011328",
"http://www.disease-ontology.org/api/metadata/DOID:649",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017096",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+... |
58a957a8cc344ae31e000001 | yesno | Does Vitamin D induce autophagy? | [
"Yes, vitamin D induces autophagy."
] | [
"yes"
] | [
" 1,25(OH)2D treatment was accompanied by autophagy activation ",
"Autophagy signaling pathway was regulated by vitamin D3",
"vitamin D induces autophagy",
"Vitamin D shows promise for the prevention and amelioration of pathologic responses in IBD, an effect that is mediated, at least in part, by the inductio... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27915989",
"http://www.ncbi.nlm.nih.gov/pubmed/27430408",
"http://www.ncbi.nlm.nih.gov/pubmed/26562100",
"http://www.ncbi.nlm.nih.gov/pubmed/27174720"
] | [] | [] |
5883868b2305cd7e21000005 | summary | What is sQTLseekeR? | [
"sQTLseekeR is an R package for the identification of genetic variants associated with alternative splicing. It is based on a statistical framework that uses a distance-based approach to compute the variability of splicing ratios across observations, and a non-parametric analogue to multivariate analysis of varianc... | [] | [
"Identification of genetic variants associated with alternative splicing using sQTLseekeR.",
"We develop a statistical framework that uses a distance-based approach to compute the variability of splicing ratios across observations, and a non-parametric analogue to multivariate analysis of variance. We implement t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25140736"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017398",
"http://amigo.geneontology.org/amigo/term/GO:0000380"
] |
58a3423e60087bc10a000019 | summary | What is Creutzfeldt-Jakob Disease (CJD)? | [
"Creutzfeldt-Jakob disease (CJD) is the most prevalent of the human prion diseases, which are fatal and transmissible neurodegenerative diseases caused by the infectious prion protein (PrP(Sc)). The origin of CJD is unknown, although the initiating event is thought to be the stochastic misfolding of endogenous prio... | [] | [
"Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disease affecting the central nervous system",
"Creutzfeldt-Jakob disease (sCJD) is the most prevalent of the human prion diseases, which are fatal and transmissible neurodegenerative diseases caused by the infectious pri... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21303352",
"http://www.ncbi.nlm.nih.gov/pubmed/11115241",
"http://www.ncbi.nlm.nih.gov/pubmed/1777133",
"http://www.ncbi.nlm.nih.gov/pubmed/26840797",
"http://www.ncbi.nlm.nih.gov/pubmed/16023527",
"http://www.ncbi.nlm.nih.gov/pubmed/9660576",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:11949",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007562"
] |
5895b9ae7d9090f35300000a | summary | Describe what is athelia syndrome? | [
"Athelia is a very rare entity that is defined by the absence of the nipple-areola complex."
] | [] | [
"Athelia is a very rare entity that is defined by the absence of the nipple-areola complex. ",
"Absence of the nipple, areola (athelia), or the breast tissue (amastia) is less frequent.",
"The absence of nipple-areola complex is a rare entity and is always associated with other anomalies. This paper described a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24872738",
"http://www.ncbi.nlm.nih.gov/pubmed/24781087",
"http://www.ncbi.nlm.nih.gov/pubmed/15950955"
] | [] | [] |
5896399978275d0c4a00000b | yesno | Is RASA2 involved in melanoma? | [
"Yes. Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was asso... | [
"yes"
] | [
"Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associate... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26502337"
] | [] | [
"http://www.uniprot.org/uniprot/RASA2_RAT",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008545",
"http://www.disease-ontology.org/api/metadata/DOID:1909",
"http://www.uniprot.org/uniprot/RASA2_HUMAN",
"http://www.uniprot.org/uniprot/RASA2_MOUSE"
] |
589c8ef878275d0c4a000042 | summary | What is BioCreative? | [
"A community wide effort to evaluate biomedical information extraction and text mining."
] | [] | [
" two biomedical named entity recognition (NER) comparative evaluations that have been held to date, namely BioCreative and Coling ",
"The BioCreative II.5 community challenge addressed these tasks in a competition-style assessment to evaluate and compare different methodologies, to make aware of the increasing a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18629295",
"http://www.ncbi.nlm.nih.gov/pubmed/18834491",
"http://www.ncbi.nlm.nih.gov/pubmed/22151647",
"http://www.ncbi.nlm.nih.gov/pubmed/23327936",
"http://www.ncbi.nlm.nih.gov/pubmed/18834496",
"http://www.ncbi.nlm.nih.gov/pubmed/16504116",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D063369"
] |
58a32edd60087bc10a000012 | factoid | What is Contrave prescribed for? | [
"Contrave(?) is a combination of naltrexone hydrochloride extended release and bupropion hydrochloride extended release for the treatment of obesity",
"Contrave(®) is a combination of naltrexone hydrochloride extended release and bupropion hydrochloride extended release for the treatment of obesity",
"Contrave(... | [
"Obesity"
] | [
"Contrave(®) is a combination of naltrexone hydrochloride extended release and bupropion hydrochloride extended release for the treatment of obesity",
"Assuming that the results of the Contrave phase III clinical program reaffirm the efficacy and safety of the drug combination, this agent could be approved and la... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20673995",
"http://www.ncbi.nlm.nih.gov/pubmed/22313529",
"http://www.ncbi.nlm.nih.gov/pubmed/26679384",
"http://www.ncbi.nlm.nih.gov/pubmed/26105116",
"http://www.ncbi.nlm.nih.gov/pubmed/25258511",
"http://www.ncbi.nlm.nih.gov/pubmed/26222044",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009271",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055553",
"http://www.biosemantics.org/jochem#4276121",
"http://www.biosemantics.org/jochem#4249647",
"https://www.nlm.nih.gov/cgi/m... |
58a2ced760087bc10a000004 | factoid | Which is the chromosome area that the human gene coding for the dopamine transporter (DAT1) is located to? | [
"The gene encoding DAT1 consists of 15 exons spanning 60 kb and is located on chromosome 5p15.3."
] | [
"5p15.3"
] | [
"The gene encoding DAT1 consists of 15 exons spanning 60 kb on chromosome 5p15.32.",
"The locus of the solute carrier 6A3 (SLC6A3; dopamine transporter 1; DAT1) localizes to 5p15.33; the gene has repeatedly been implicated in the etiology of ADHD. ",
"In 29 adults with attention deficit hyperactivity disorder (... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16222334",
"http://www.ncbi.nlm.nih.gov/pubmed/1478653",
"http://www.ncbi.nlm.nih.gov/pubmed/19779799",
"http://www.ncbi.nlm.nih.gov/pubmed/16861140",
"http://www.ncbi.nlm.nih.gov/pubmed/17579611"
] | [] | [
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4275128",
"http://www.biosemantics.org/jochem#4275128",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004298",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D05048... |
58a877cf38c171fb5b000004 | factoid | What type of mutation is causing the industrial melanism phenotype in peppered moths? | [
"The mutation event giving rise to industrial melanism in Britain was the insertion of a large, tandemly repeated, transposable element into the first intron of the gene cortex."
] | [
"transposable element insertion"
] | [
"The industrial melanism mutation in British peppered moths is a transposable element.",
"Here we show that the mutation event giving rise to industrial melanism in Britain was the insertion of a large, tandemly repeated, transposable element into the first intron of the gene cortex."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/27251284",
"http://www.ncbi.nlm.nih.gov/pubmed/12298233",
"http://www.ncbi.nlm.nih.gov/pubmed/12140267"
] | [] | [] |
58a3428d60087bc10a00001b | factoid | What gene is mutated in Huntington's disease? | [
"Huntington disease (HD; OMIM 143100), a progressive neurodegenerative disorder, is caused by an expanded trinucleotide CAG (polyQ) motif in the HTT gene. Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington's disease (HD).",
"Huntington disease is a progressi... | [
"HTT or IT-15 gene or HD gene"
] | [
"Huntington disease (HD; OMIM 143100), a progressive neurodegenerative disorder, is caused by an expanded trinucleotide CAG (polyQ) motif in the HTT gene.",
"Huntington's disease (HD) is caused by a genetic mutation that results in polyglutamine expansion in the N-terminal regions of huntingtin.",
"Mutations of... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25993131",
"http://www.ncbi.nlm.nih.gov/pubmed/1839672",
"http://www.ncbi.nlm.nih.gov/pubmed/25254119",
"http://www.ncbi.nlm.nih.gov/pubmed/26863614",
"http://www.ncbi.nlm.nih.gov/pubmed/18651325",
"http://www.ncbi.nlm.nih.gov/pubmed/19059613",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:1289",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006816",
"http://www.disease-ontology.org/api/metadata/DOID:12858"
] |
587e07023ec846c24f000001 | factoid | Which software package is available for the analysis of conserved genomic loci? | [
"PHYLUCE is a software package for the analysis of conserved genomic loci. It identifies targeted, enriched loci from the off-target background data; aligns enriched contigs representing conserved loci to one another; and prepare and manipulate these alignments for subsequent phylogenomic inference. PHYLUCE is an e... | [
"PHYLUCE"
] | [
"PHYLUCE is a software package for the analysis of conserved genomic loci",
"Prior to downstream inference, data from these types of targeted enrichment studies must undergo preprocessing to assemble contigs from sequence data; identify targeted, enriched loci from the off-target background data; align enriched c... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26530724"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012984",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017124"
] |
5895bc397d9090f35300000b | factoid | Mutation of which gene is implicated in the Christianson syndrome? | [
"Christianson syndrome is caused by mutations in SLC9A6 and is characterized by severe intellectual disability, absent speech, microcephaly, ataxia, seizures, and behavioral abnormalities."
] | [
"SLC9A6"
] | [
"X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities.",
"CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in ea... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24630051",
"http://www.ncbi.nlm.nih.gov/pubmed/18342287",
"http://www.ncbi.nlm.nih.gov/pubmed/26421989",
"http://www.ncbi.nlm.nih.gov/pubmed/25044251",
"http://www.ncbi.nlm.nih.gov/pubmed/25273398",
"http://www.ncbi.nlm.nih.gov/pubmed/27142213",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009154"
] |
58a9d3cd396a458e50000004 | summary | What is Eteplirsen (Exondys 51)? | [
"Eteplirsen (Exondys 51) is an antisense oligonucleotide designed to induce exon 51 skipping that is developed by Sarepta Therapeutics. Intravenous eteplirsen has received accelerated approval from the US FDA for the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gen... | [] | [
"Eteplirsen (Exondys 51) is an antisense oligonucleotide designed to induce exon 51 skipping that is developed by Sarepta Therapeutics. Intravenous eteplirsen has received accelerated approval from the US FDA for the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gen... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27807823",
"http://www.ncbi.nlm.nih.gov/pubmed/21540335",
"http://www.ncbi.nlm.nih.gov/pubmed/25980936",
"http://www.ncbi.nlm.nih.gov/pubmed/22086232",
"http://www.ncbi.nlm.nih.gov/pubmed/27936976",
"http://www.ncbi.nlm.nih.gov/pubmed/23907995",
"http://www.ncbi.nlm.n... | [] | [] |
587d3873ae41fa4569000002 | summary | What are the SINEUPs? | [
"SINEUPs represent a new class of natural and synthetic antisense long non-coding RNAs that activate translation. These molecules have been named SINEUPs since their function requires the activity of an embedded inverted SINEB2 sequence to UP-regulate translation. Natural SINEUPs suggest that embedded Transposable ... | [] | [
"SINEUPs: A new class of natural and synthetic antisense long non-coding RNAs that activate translation",
"In this review, we will detail the discovery of a new functional class of natural and synthetic antisense lncRNAs that stimulate translation of sense mRNAs. These molecules have been named SINEUPs since thei... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26259533",
"http://www.ncbi.nlm.nih.gov/pubmed/27646849",
"http://www.ncbi.nlm.nih.gov/pubmed/26029048",
"http://www.ncbi.nlm.nih.gov/pubmed/26045368",
"http://www.ncbi.nlm.nih.gov/pubmed/25883552",
"http://www.ncbi.nlm.nih.gov/pubmed/27265476"
] | [] | [] |
58a8045860087bc10a000035 | factoid | What is trichotillomania? | [
"Trichotillomania is a hair pulling disorder."
] | [
"Trichotillomania is a hair pulling disorder."
] | [
"Trichotillomania (hair pulling disorder, HPD) is characterized by significant psychological distress, childhood-onset, and, in adults, certain cognitive deficits such as inhibitory control. ",
"TRICHOTILLOMANIA (HAIR PULLING DISORDER)",
"Hair pulling disorder (HPD; trichotillomania) is thought to be associated... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27137957",
"http://www.ncbi.nlm.nih.gov/pubmed/26001984",
"http://www.ncbi.nlm.nih.gov/pubmed/26580849"
] | [] | [] |
587f857b8ce3255b64000001 | summary | What is the mechanism of action of raxibacumab? | [
"Raxibacumab is a recombinant human IgG1 monoclonal antibody that binds the protective antigen of Bacillus anthracis, thus blocking toxin effects.\nIt is approved to treat inhalational anthrax."
] | [] | [
" Raxibacumab, an IgG1 monoclonal antibody, binds the protective antigen (PA) of Bacillus anthracis, thus blocking toxin effects and leading to improved survival in the rabbit and monkey models of inhalational anthrax. ",
"RESULTS: Interesting results were obtained using monoclonal antibodies: raxibacumab, cAb29 ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24812521",
"http://www.ncbi.nlm.nih.gov/pubmed/20068396",
"http://www.ncbi.nlm.nih.gov/pubmed/26648915",
"http://www.ncbi.nlm.nih.gov/pubmed/23344456",
"http://www.ncbi.nlm.nih.gov/pubmed/26094508",
"http://www.ncbi.nlm.nih.gov/pubmed/25487792",
"http://www.ncbi.nlm.n... | [] | [
"http://www.biosemantics.org/jochem#4002353",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D045504"
] |
58a8a51b7f77222767000001 | summary | What is the effect of CPEB3 binding to the CPE domain? | [
"The cytoplasmic polyadenylation element (CPE) is the binding platform for CPE-binding protein (CPEB), which promotes polyadenylation-induced translation."
] | [] | [
"CPEB (Cytoplasmic Polyadenylation Element Binding) proteins are a family of four RNA-binding proteins that regulate the translation of maternal mRNAs controlling meiotic cell cycle progression",
"The family of cytoplasmic polyadenylation element binding proteins CPEB1, CPEB2, CPEB3, and CPEB4 binds to the 3'-unt... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17481902",
"http://www.ncbi.nlm.nih.gov/pubmed/26398195",
"http://www.ncbi.nlm.nih.gov/pubmed/25066254",
"http://www.ncbi.nlm.nih.gov/pubmed/17923234",
"http://www.ncbi.nlm.nih.gov/pubmed/23776146"
] | [] | [] |
58a6b98860087bc10a000028 | yesno | Is SUMOylation a post-translational modification in eukaryotes? | [
"Yes, SUMOylation that is the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes."
] | [
"yes"
] | [
"SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. ",
"Plants have evolved to cope with changing environmental c... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18468939",
"http://www.ncbi.nlm.nih.gov/pubmed/20414307",
"http://www.ncbi.nlm.nih.gov/pubmed/25561743",
"http://www.ncbi.nlm.nih.gov/pubmed/15744326",
"http://www.ncbi.nlm.nih.gov/pubmed/21178495",
"http://www.ncbi.nlm.nih.gov/pubmed/22192309",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0043687",
"http://amigo.geneontology.org/amigo/term/GO:0016925",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D058207"
] |
58a9cd03396a458e50000003 | summary | What is the Shelterin complex? | [
"Human telomeres are associated with the shelterin complex which consists of six telomere-associated proteins that specifically bind to telomeric DNA. Alterations or removal of individual shelterin components would lead to telomere uncapping and telomere dysfunction, resulting in cellular senescence and transformat... | [] | [
"Human telomeres are associated with the shelterin complex which consists of six telomere-associated proteins that specifically bind to telomeric DNA. Alterations or removal of individual shelterin components would lead to telomere uncapping and telomere dysfunction, resulting in cellular senescence and transformat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27814571",
"http://www.ncbi.nlm.nih.gov/pubmed/26598048",
"http://www.ncbi.nlm.nih.gov/pubmed/26748096",
"http://www.ncbi.nlm.nih.gov/pubmed/26921407",
"http://www.ncbi.nlm.nih.gov/pubmed/27135879",
"http://www.ncbi.nlm.nih.gov/pubmed/26871633",
"http://www.ncbi.nlm.n... | [] | [] |
58a95c711978bbde22000001 | factoid | What disease is the drug aducanumab targeting? | [
"Aducanumab is an anti-Aβ antibody being developed for the treatment of Alzheimer's disease (AD)."
] | [
"Alzheimer's disease"
] | [
" Most importantly, recent trials of three different Aβ antibodies (solanezumab, crenezumab, and aducanumab) have suggested a slowing of cognitive decline in post hoc analyses of mild AD subjects. ",
"ecent results from trials of agents such as aducanumab are encouraging but must also be interpreted with caution.... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27025652",
"http://www.ncbi.nlm.nih.gov/pubmed/27810931",
"http://www.ncbi.nlm.nih.gov/pubmed/27582220",
"http://www.ncbi.nlm.nih.gov/pubmed/27251914"
] | [] | [] |
58932cd87d9090f353000001 | list | Which human syndromes have been detected with Fluorescence in situ hybridization (FISH)? | [
"To explore the clonal evolution of monosomy 7 in patients with aplastic anemia (AA).Monosomy 7 (-7) in 81 AA patients with normal karyotype at diagnosis and 46 AA treated with immunosuppressive therapy (IST) and more than 6 months of recombinant human granulocyte colony-stimulating factor (rhuG-CSF) were detected ... | [
"Myelodysplastic Syndrome",
"MDS",
"Genetic syndromes caused by somatic chromosomal mosaicism",
"Prader Willi syndrome",
"PWS",
"Angelman syndrome",
"AS",
"Williams syndrome",
"Smith Magenis syndrome",
"Velocardiofacial syndrome",
"Jacobsen syndrome",
"Shwachman-Diamond syndrome",
"Saethre-C... | [
"We demonstrate that, using a sensitive FISH technique, 12p deletion occurs significantly more frequently in MDS than previously described (7.6% by CD34+ PB-FISH vs. 1.6% by CBA, P<0.001) and is often associated with other aberrations (93% by CD34+ PB-FISH vs. 60% by CBA)",
"Somatic chromosomal mosaicism arising ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26355708",
"http://www.ncbi.nlm.nih.gov/pubmed/1394103",
"http://www.ncbi.nlm.nih.gov/pubmed/16351727",
"http://www.ncbi.nlm.nih.gov/pubmed/12505257",
"http://www.ncbi.nlm.nih.gov/pubmed/26066831",
"http://www.ncbi.nlm.nih.gov/pubmed/11424143",
"http://www.ncbi.nlm.ni... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017404",
"http://www.disease-ontology.org/api/metadata/DOID:11983",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011218",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Fin... |
589a246378275d0c4a00002c | list | List symptoms of EAST syndrome. | [
"Epilepsy, ataxia, sensorineural deafness, and tubulopathy comprise EAST syndrome that is associated with recessive mutations in the KCNJ10 gene."
] | [
"epilepsy",
"ataxia",
"sensorineural deafness",
"tubulopathy"
] | [
"This condition is characterized by 4 cardinal features; Epilepsy, Ataxia, Sensorineural deafness, and (a renal salt-wasting) Tubulopathy, hence the acronym EAST syndrome. ",
"Generation and validation of a zebrafish model of EAST (epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome.",
"Recessive... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27500072",
"http://www.ncbi.nlm.nih.gov/pubmed/21300747",
"http://www.ncbi.nlm.nih.gov/pubmed/21633011",
"http://www.ncbi.nlm.nih.gov/pubmed/23471908",
"http://www.ncbi.nlm.nih.gov/pubmed/23924083",
"http://www.ncbi.nlm.nih.gov/pubmed/20651251",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012816"
] |
58a1c0f178275d0c4a000056 | factoid | When did the polio vaccine becomes available? | [
"Inactivated poliovirus vaccine (IPV), developed in the USA by Jonas Salk in the early 1950s, was field tested in 1954,",
"The Salk polio Vaccine was field tested in 1954."
] | [
"1954"
] | [
"Inactivated poliovirus vaccine (IPV), developed in the USA by Jonas Salk in the early 1950s, was field tested in 1954,",
"the use of an oral polio vaccine (OPV) during a vaccination campaign launched by the Wistar Institute, Philadelphia, PA, USA, in the Belgian Congo in 1958 and 1959. "
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/12931339",
"http://www.ncbi.nlm.nih.gov/pubmed/14997988",
"http://www.ncbi.nlm.nih.gov/pubmed/11326104"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000071497",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011051",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011052",
"https://www.nlm.nih.gov/cgi... |
5894597e7d9090f353000004 | yesno | Is Annexin V an apoptotic marker? | [
"Yes, annexin V is an early apoptotic marker.",
"Yes, Annexin V is an apoptotic marker."
] | [
"yes"
] | [
"The apoptosis of the MSCs was induced by subjecting the cells to OGD conditions for 4 h and was detected by Annexin V/PI and Hoechst 33258 staining. ",
"In addition to the antimicrobial activity, we found that treatment of the cancer cell lines, Jurkat T-cells, Granta cells, and melanoma cells, with the Pseudomo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24412631",
"http://www.ncbi.nlm.nih.gov/pubmed/16046522",
"http://www.ncbi.nlm.nih.gov/pubmed/23000925",
"http://www.ncbi.nlm.nih.gov/pubmed/20122665",
"http://www.ncbi.nlm.nih.gov/pubmed/26582221",
"http://www.ncbi.nlm.nih.gov/pubmed/27619241",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/ANXA5_CYNPY",
"http://www.uniprot.org/uniprot/ANXA5_MOUSE",
"http://www.uniprot.org/uniprot/ANXA5_HUMAN",
"http://www.uniprot.org/uniprot/ANXA5_MACFA",
"http://www.uniprot.org/uniprot/ANXA5_BOVIN",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Ter... |
589c42b178275d0c4a00003f | list | Which are the lipid lowering drugs administered in patients with Coronary Artery Disease (CAD)? | [
"The lipid lowering drugs administered in patients with Coronary Artery Disease (CAD) are:\n1) Statins\n2) Fibrates\n3) Resins\n4) Niacin\n5) Cholesterol absorption-inhibiting drugs."
] | [
"Statins",
"Fibrates",
"Resins",
"Niacin",
"Cholesterol absorption-inhibiting drugs"
] | [
"Impact of adding ezetimibe to statin to achieve low-density lipoprotein cholesterol goal (from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation [COURAGE] trial).",
"After maximizing statin dose, ezetimibe was added to reach the LDL cholesterol goal in 34% of patients (n = 734). ",... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23074505",
"http://www.ncbi.nlm.nih.gov/pubmed/23409830",
"http://www.ncbi.nlm.nih.gov/pubmed/15174957",
"http://www.ncbi.nlm.nih.gov/pubmed/19801853",
"http://www.ncbi.nlm.nih.gov/pubmed/19090788",
"http://www.ncbi.nlm.nih.gov/pubmed/23538020",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:3393",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003324",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003327"
] |
58a3196360087bc10a00000b | summary | What are PD-1 inhibitors? | [
"The programmed death-1 (PD-1) pathway negatively regulates T-cell activation and has an important role in regulating antitumor host immunity. Monoclonal antibodies directed against PD-1 or the PD-1 ligand (PD-L1) are used to treat cancer. "
] | [] | [
" The programmed death-1 (PD-1) pathway negatively regulates T-cell activation and has an important role in regulating antitumor host immunity. Monoclonal antibodies directed against PD-1 or the PD-1 ligand (PD-L1) have shown activity in several tumor types with preliminary data suggesting a relationship between PD... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27534574",
"http://www.ncbi.nlm.nih.gov/pubmed/25682878",
"http://www.ncbi.nlm.nih.gov/pubmed/22740686",
"http://www.ncbi.nlm.nih.gov/pubmed/26775720",
"http://www.ncbi.nlm.nih.gov/pubmed/27936870",
"http://www.ncbi.nlm.nih.gov/pubmed/26588948",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D061026",
"http://www.uniprot.org/uniprot/PDCD1_MOUSE"
] |
58a93877ee23e0236b000001 | yesno | Is the protein lefty an inhibitor of nodal? | [
"Yes, lefty is an inhibitor of nodal."
] | [
"yes"
] | [
"The expression of lefty, an inhibitor of nodal is often reduced in tumor cells.",
" Nodal, and an inhibitor, Lefty.",
"as well as the expression of Lefty, an inhibitor of nodal signaling,",
"he Nodal inhibitor lefty",
"The morphogen Nodal was proposed to form a long-range signaling gradient via a reaction-... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26506307",
"http://www.ncbi.nlm.nih.gov/pubmed/25669884",
"http://www.ncbi.nlm.nih.gov/pubmed/25672326",
"http://www.ncbi.nlm.nih.gov/pubmed/26377939",
"http://www.ncbi.nlm.nih.gov/pubmed/25684355"
] | [] | [] |
58a326da60087bc10a00000e | list | List drugs withdrawn from the market for cardiovascular adverse events. | [
"Over the years, a number of different drugs have been withdrawn for Cardiotoxicity. Drugs like Clobutinol, that induce cardiac arrhythmias by a blockade of the potassium channel coded by the hERG channel, sibutramine for weight loss and Cox2 inhibitors, Rofecoxib and Valdecoxib have been withdrawn from the market... | [
"Rofecoxib",
"Valdecoxib",
"Sibutramine",
"Clobutinol",
"Sertindole",
"aprotinin"
] | [
" rofecoxib was voluntarily removed from the market for increased cardiovascular risk and in April 2005, valdecoxib was also withdrawn, at least in part, due to excess cardiovascular risk.",
"A common over-the-counter (OTC) non-opioid antitussive drug, clobutinol, was recently withdrawn from the market due to its... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21265828",
"http://www.ncbi.nlm.nih.gov/pubmed/21412876",
"http://www.ncbi.nlm.nih.gov/pubmed/26934640",
"http://www.ncbi.nlm.nih.gov/pubmed/19034038",
"http://www.ncbi.nlm.nih.gov/pubmed/21249650",
"http://www.ncbi.nlm.nih.gov/pubmed/25084209",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D064420",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000069451"
] |
5884793ce56acf5176000008 | yesno | Is Migalastat used for treatment of Fabry Disease? | [
"Yes, Migalastat is approved for treatment of Fabry disease. Migalastat is an oral pharmacological chaperone developed as an alternative to intravenous enzyme replacement therapy (ERT), stabilises specific mutant (amenable) forms of α-Gal to facilitate normal lysosomal trafficking."
] | [
"yes"
] | [
"Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study.",
"BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and ac... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27834756",
"http://www.ncbi.nlm.nih.gov/pubmed/27351440",
"http://www.ncbi.nlm.nih.gov/pubmed/27657681",
"http://www.ncbi.nlm.nih.gov/pubmed/23474038",
"http://www.ncbi.nlm.nih.gov/pubmed/19387866",
"http://www.ncbi.nlm.nih.gov/pubmed/24189976",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:14499",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000795"
] |
58a9bbe81978bbde22000007 | factoid | Where are Paneth cells located? | [
"Paneth cells are located in the intestinal crypt base columnar cells (CBCCs)."
] | [
"in the intestinal crypt base columnar cells"
] | [
"The intestinal stem cell niche comprises both epithelial cells, in particular the Paneth cell, ",
"Paneth cells have been reported in colorectal adenomas and adenocarcinomas;",
" injury to Paneth cells (PCs) in the intestinal crypts",
"resence of Paneth cells at the bottom of the crypts of Lieberkühn.",
"P... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21122555",
"http://www.ncbi.nlm.nih.gov/pubmed/19397593",
"http://www.ncbi.nlm.nih.gov/pubmed/23006982",
"http://www.ncbi.nlm.nih.gov/pubmed/24439803",
"http://www.ncbi.nlm.nih.gov/pubmed/23232853",
"http://www.ncbi.nlm.nih.gov/pubmed/19788585"
] | [] | [] |
589aec4778275d0c4a000037 | list | Which are the types of viral meningitis? | [
"Aseptic meningitis is the most common type of meningitis and is characterized by meningeal inflammation that is not linked to identifiable bacterial pathogens in cerebrospinal fluid (CSF). It can be originated from infection from:\n1) Varicella-zoster virus (VZV)\n2) Herpes simplex types I and II (HSV-1, HSV-2)\n3... | [
"Varicella-zoster virus",
"VZV",
"Herpes simplex types I and II",
"HSV-1",
"HSV-2",
"Epstein-Barr virus",
"EBV",
"Cytomegalovirus",
"CMV",
"Enteroviruses",
"EV",
"Parechoviruses",
"HPeV",
"Human rhinoviruses",
"HRVs",
"Echovirus types 6, 9, 11",
"West Nile Virus",
"WNV"
] | [
"Aseptic meningitis is the most common type of meningitis and is characterized by meningeal inflammation that is not linked to identifiable bacterial pathogens in cerebrospinal fluid (CSF).",
"The results indicate a considerable rate of herpesvirus infection in patients with aseptic meningitis, and that VZV is th... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16909784",
"http://www.ncbi.nlm.nih.gov/pubmed/22246843",
"http://www.ncbi.nlm.nih.gov/pubmed/25042344",
"http://www.ncbi.nlm.nih.gov/pubmed/26568804",
"http://www.ncbi.nlm.nih.gov/pubmed/22798048",
"http://www.ncbi.nlm.nih.gov/pubmed/8972676",
"http://www.ncbi.nlm.ni... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008581",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008582",
"http://www.disease-ontology.org/api/metadata/DOID:10310",
"http://www.disease-ontology.org/api/metadata/DOID:12157",
"htt... |
58a0c09778275d0c4a000052 | list | What are the different classes of orally administered drugs used to treat diabetes | [
"There are a number of classes of medications tha are used to treat Type 2 diabetes. These include biguanides like metformin, which decreased hepatic glucose release; sulfonyureas like Glimepride, metglitinides like repaglin and d-phenylalanine derivatives, all of which stimulate pancreatic insulin release; Glitizo... | [
"Biguanides",
"Sulfonylureas",
"Meglitinides",
"D-Phenylalanine Derivatives",
"glitazones",
"DPP-4 Inhibitors",
"Alpha-glucosidase inhibitors",
"bile acid sequestrants"
] | [
" achieved by selectively inhibiting sodium-glucose co-transporter 2 (SGLT2).",
"After a decade-long effort to improve the pharmacokinetics of GLP1, a number of GLP1 analogues are currently available on the market",
" short-acting glucagon-like peptide-1 receptor agonists exenatide and lixisenatide. ",
" Sulp... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12766122",
"http://www.ncbi.nlm.nih.gov/pubmed/26932742",
"http://www.ncbi.nlm.nih.gov/pubmed/26158794",
"http://www.ncbi.nlm.nih.gov/pubmed/9540451",
"http://www.ncbi.nlm.nih.gov/pubmed/11075314",
"http://www.ncbi.nlm.nih.gov/pubmed/26787264",
"http://www.ncbi.nlm.ni... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016640",
"http://www.disease-ontology.org/api/metadata/DOID:11714",
"http://www.disease-ontology.org/api/metadata/DOID:0050524",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D048909",
"h... |
5883bce3e56acf5176000003 | list | Which pipelines are used for analyzing data from ChIP-nexus experiments? | [
"PeakXus and Q-nexus enable comprehensive transcription factor binding site discovery from ChIP-nexus experiments."
] | [
"PeakXus",
"Q-nexus"
] | [
"PeakXus: comprehensive transcription factor binding site discovery from ChIP-Nexus and ChIP-Exo experiments.",
"We describe a peak caller PeakXus that is specifically designed to leverage the increased resolution of ChIP-exo/Nexus and developed with the aim of making as few assumptions of the data as possible to... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27814676",
"http://www.ncbi.nlm.nih.gov/pubmed/27587683"
] | [] | [] |
589c8e5e78275d0c4a000041 | summary | What do statins do? | [
"Statins lower high cholesterol",
"Statins, which specifically inhibit HMG Co-A reductase, the rate-limiting step of cholesterol biosynthesis, are widely prescribed to reduce serum cholesterol and cardiac risk,"
] | [] | [
"Statins are inhibitors of HMG-CoA reductase, the enzyme that catalyzes the reduction of HMG-CoA to mevalonic acid by NADPH",
"Statins, which specifically inhibit HMG Co-A reductase, the rate-limiting step of cholesterol biosynthesis, are widely prescribed to reduce serum cholesterol and cardiac risk,",
"OBJECT... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21784376",
"http://www.ncbi.nlm.nih.gov/pubmed/17245169",
"http://www.ncbi.nlm.nih.gov/pubmed/26405105",
"http://www.ncbi.nlm.nih.gov/pubmed/17001070",
"http://www.ncbi.nlm.nih.gov/pubmed/23629822",
"http://www.ncbi.nlm.nih.gov/pubmed/19225884",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019161",
"http://amigo.geneontology.org/amigo/term/GO:0036273"
] |
58a9c152396a458e50000001 | factoid | Which cells secretes alpha defensin 5? | [
"Human enteric α-defensins (HD5 and HD6), major antimicrobial peptides produced by Paneth cells in the intestine, play important roles in intestinal innate immunity."
] | [
"Intestinal Paneth cells secretes alpha-defensin 5"
] | [
"The major tissue in which HD5 is expressed is the crypt of the small intestine, an anaerobic niche that should allow for substantial pools of both oxidized and (partly) reduced HD5. ",
"Human α-defensin 5 (HD5) exhibits broad spectrum antimicrobial activity and plays an important role in mucosal immunity of the ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26206286",
"http://www.ncbi.nlm.nih.gov/pubmed/25664683",
"http://www.ncbi.nlm.nih.gov/pubmed/25643281",
"http://www.ncbi.nlm.nih.gov/pubmed/25433720",
"http://www.ncbi.nlm.nih.gov/pubmed/25970658",
"http://www.ncbi.nlm.nih.gov/pubmed/25540379",
"http://www.ncbi.nlm.n... | [] | [] |
58a341eb60087bc10a000018 | yesno | Do statins cause diabetes? | [
"The relationship between T2DM and statins is further complicated since these drugs can cause new onset diabetes (NOD) although there is an overall benefit in terms of preventing vascular events.",
"Statin use has been associated with increased risk of developing type 2 diabetes (T2DM), and with impaired glycemic... | [
"yes"
] | [
"Statin use has been associated with increased risk of developing type 2 diabetes (T2DM), and with impaired glycemic control in T2DM patients",
"The relationship between T2DM and statins is further complicated since these drugs can cause new onset diabetes (NOD) although there is an overall benefit in terms of pr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26806344",
"http://www.ncbi.nlm.nih.gov/pubmed/25245638",
"http://www.ncbi.nlm.nih.gov/pubmed/24404512",
"http://www.ncbi.nlm.nih.gov/pubmed/26597211",
"http://www.ncbi.nlm.nih.gov/pubmed/25208056",
"http://www.ncbi.nlm.nih.gov/pubmed/22845189",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003924"
] |
58a8903b38c171fb5b000006 | factoid | What is the effect of nocodazole cell treatment? | [
"Nocodazole trigger mitotic arrest."
] | [
"Mitotic arrest"
] | [
"antimitotic SAC-inducing agents (i.e., nocodazole",
"spindle assembly checkpoint (SAC)",
"Cells can also be enriched in mitosis using nocodazole",
" escape of metaphase I arrest induced by nocodazole treatment ",
" the treatment of CD4+T-cells with nocodazole, which disrupts the microtubular network,",
"... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27177335",
"http://www.ncbi.nlm.nih.gov/pubmed/27609478",
"http://www.ncbi.nlm.nih.gov/pubmed/27262873",
"http://www.ncbi.nlm.nih.gov/pubmed/27815904",
"http://www.ncbi.nlm.nih.gov/pubmed/27815897",
"http://www.ncbi.nlm.nih.gov/pubmed/27833610"
] | [] | [] |
587e2a0cc32c812009000001 | summary | What is Path2PPI? | [
"Path2PPI is an R package to identify protein-protein interaction (PPI) networks for fully sequenced organisms for which nearly none PPI are known. Path2PPI predicts PPI networks based on sets of proteins from well-established model organisms, providing an intuitive visualization and usability. It can be used to co... | [] | [
"Path2PPI: an R package to predict protein-protein interaction networks for a set of proteins",
"We introduce Path2PPI, a new R package to identify protein-protein interaction (PPI) networks for fully sequenced organisms for which nearly none PPI are known. Path2PPI predicts PPI networks based on sets of proteins... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26733452"
] | [] | [] |
5884fe4ce56acf5176000010 | list | SPAG5 was implicated in which cancers? | [
"SPAG5 was implicated in prostate cancer, lung cancer and cervical cancer."
] | [
"prostate cancer",
"lung cancer",
"cervical cancer",
"breast cancer"
] | [
"BACKGROUND: We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) attracted our attention. SPAG5 was recently identified as an oncogene participating in lung cance... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24853425",
"http://www.ncbi.nlm.nih.gov/pubmed/21412013",
"http://www.ncbi.nlm.nih.gov/pubmed/27312051",
"http://www.ncbi.nlm.nih.gov/pubmed/27037000",
"http://www.ncbi.nlm.nih.gov/pubmed/24194916"
] | [] | [
"http://www.uniprot.org/uniprot/SPAG5_HUMAN",
"http://www.uniprot.org/uniprot/SPAG5_MOUSE"
] |
58a3275960087bc10a00000f | summary | What are some of the effects of Zika Virus in infected individuals? | [
"While most of the symptoms of zika virus are relatively mild, zika virus in pregnant mothers can cause microcephaly and other congenital defects in the fetus."
] | [] | [
"Maternal-fetal transmission of Zika virus has been documented; evidence suggests that congenital Zika virus infection is associated with microcephaly and other adverse pregnancy and infant outcomes",
"Recent studies have reported an increase in the number of fetuses and neonates with microcephaly whose mothers w... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26897108",
"http://www.ncbi.nlm.nih.gov/pubmed/22389730",
"http://www.ncbi.nlm.nih.gov/pubmed/27557413",
"http://www.ncbi.nlm.nih.gov/pubmed/25294619",
"http://www.ncbi.nlm.nih.gov/pubmed/27149205",
"http://www.ncbi.nlm.nih.gov/pubmed/27088494",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000071243",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000071244",
"http://www.disease-ontology.org/api/metadata/DOID:0060478"
] |
589ae59c78275d0c4a000036 | summary | What is the function of Oseltamivir when administered during flu? | [
"Oseltamivir (has known by its brand name 'Tamiflu') is a prodrug, requiring ester hydrolysis for conversion to the active form, Oseltamivir carboxylate. Oseltamivir is the first orally active neuraminidase inhibitor and it is an antiviral drug for the treatment of Swine Flu."
] | [] | [
"All patients were given specific antiviral therapy (oseltamivir).",
"Oseltamivir (has known by its brand name 'Tamiflu') is a prodrug, requiring ester hydrolysis for conversion to the active form, Oseltamivir carboxylate. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed by U... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23810646",
"http://www.ncbi.nlm.nih.gov/pubmed/23794010",
"http://www.ncbi.nlm.nih.gov/pubmed/12058885",
"http://www.ncbi.nlm.nih.gov/pubmed/22754968",
"http://www.ncbi.nlm.nih.gov/pubmed/19273546",
"http://www.ncbi.nlm.nih.gov/pubmed/10708809",
"http://www.ncbi.nlm.n... | [] | [
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4242246",
"http://www.biosemantics.org/jochem#4242246",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053139",
"http://www.disease-ontology.org/api/metadata/DOID:8469",
"http://www.biosemantics.org/... |
58a2ccec60087bc10a000003 | summary | What is the composition of the gamma-secretase complex? | [
"Gamma-secretase is a multisubunit enzyme complex which is consists of four proteins: presenilin 1 (PS1) or presenilin 2 (PS2), nicastrin, Aph-1 and Pen-2."
] | [] | [
"Gamma-secretase is a widely expressed multisubunit enzyme complex which is involved in the pathogenesis of Alzheimer disease and hematopoietic malignancies through its aberrant processing of the amyloid precursor protein (APP) and Notch1, respectively.",
"Presenilin (PS1 or PS2) is the catalytic component of the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15591316",
"http://www.ncbi.nlm.nih.gov/pubmed/24723404",
"http://www.ncbi.nlm.nih.gov/pubmed/24338474",
"http://www.ncbi.nlm.nih.gov/pubmed/20299451",
"http://www.ncbi.nlm.nih.gov/pubmed/12644463",
"http://www.ncbi.nlm.nih.gov/pubmed/27059953",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0070765",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053829"
] |
58a80bc838c171fb5b000001 | list | List kinases that phosphorylates the protein Bora. | [
"During cell division Bora becomes multiply phosphorylated by a variety of cell cycle kinases, including Aurora A and Plk1, and GSK3β and Cdk1 albeit at distinctive sites."
] | [
"Cdk1",
"Plk1",
"Aurora A",
"GSK3β"
] | [
"During cell division Bora becomes multiply phosphorylated by a variety of cell cycle kinases, including Aurora A and Plk1, albeit at distinctive sites.",
"Likewise, we find that phosphorylation of Bora by Cdk1 promotes phosphorylation of human Plk1 by Aurora A suggesting that this mechanism is conserved in human... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27831827",
"http://www.ncbi.nlm.nih.gov/pubmed/25803405",
"http://www.ncbi.nlm.nih.gov/pubmed/26038951",
"http://www.ncbi.nlm.nih.gov/pubmed/24675888",
"http://www.ncbi.nlm.nih.gov/pubmed/23442801"
] | [] | [] |
587f56c392a5b8ad44000001 | yesno | Are deletions of chromosomal regulatory boundaries associated with congenital disease? | [
"Yes. Enhancer adoption caused by deletions of regulatory boundaries may contribute to a substantial minority of copy-number variation phenotypes and should thus be taken into account in their medical interpretation."
] | [
"yes"
] | [
"Deletions of chromosomal regulatory boundaries are associated with congenital disease.",
"Our results suggest that enhancer adoption caused by deletions of regulatory boundaries may contribute to a substantial minority of copy-number variation phenotypes and should thus be taken into account in their medical int... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25315429"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002872",
"http://www.disease-ontology.org/api/metadata/DOID:1086",
"http://www.disease-ontology.org/api/metadata/DOID:0080014"
] |
58a5b1fe60087bc10a000024 | factoid | What is the role of the UBC9 enzyme in the protein sumoylation pathway? | [
"The small ubiquitin-like modifier (SUMO) pathway in eukaryotes is an essential post-translational modification required for a variety of cellular processes, development and organelle biogenesis. SUMO-conjugating enzyme (Ubc9) is the sole conjunction enzyme in the SUMO pathway."
] | [
"SUMO-conjugating enzyme"
] | [
"Among the proteins involved in the sumoylation pathway, Ubc9 is the sole E2-conjugating enzyme required for sumoylation and plays a central role by interacting with almost all of the partners required for sumoylation. ",
"We also found a marked rise in levels of Ubc9, the only SUMO conjugation enzyme identified ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24991007",
"http://www.ncbi.nlm.nih.gov/pubmed/20561671",
"http://www.ncbi.nlm.nih.gov/pubmed/25311713",
"http://www.ncbi.nlm.nih.gov/pubmed/23628505",
"http://www.ncbi.nlm.nih.gov/pubmed/21510985",
"http://www.ncbi.nlm.nih.gov/pubmed/20800867",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/UBC9_CHICK",
"http://www.uniprot.org/uniprot/UBC9_MESAU",
"http://www.uniprot.org/uniprot/UBC9_XENLA",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D058207",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&te... |
587dfde9ae05ffb474000001 | yesno | Can the Micro-C XL method achieve mononucleosome resolution? | [
"Yes. Micro-C XL is an improved method for analysis of chromosome folding at mononucleosome resolution."
] | [
"yes"
] | [
"We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution",
"We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution.",
"Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genome.",
"... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27723753"
] | [] | [] |
58a0a28a78275d0c4a000051 | yesno | Can Diabetes be caused by a defect in a potassium chanel? | [
"Mutations in the KATP channel can lead to neonatal diabetes.",
"Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, respectively."
] | [
"yes"
] | [
"Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, respectively.",
"To date, all patients affected by neonatal diabetes due to a mutation in the pore-forming subunit of the channel (Kir6.2, KCNJ11) are heterozygous fo... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25931474",
"http://www.ncbi.nlm.nih.gov/pubmed/27118464",
"http://www.ncbi.nlm.nih.gov/pubmed/15746700",
"http://www.ncbi.nlm.nih.gov/pubmed/24827651"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016640",
"http://www.disease-ontology.org/api/metadata/DOID:11717",
"http://www.disease-ontology.org/api/metadata/DOID:9351",
"http://www.biosemantics.org/jochem#4277521",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=... |
58a94483ee23e0236b000003 | list | Which fimA genotypes are associated with disease? | [
"FimA has been characterized as an important virulence factor for P. gingivalis, and many studies, both animal experiments and clinical investigations, have characterized fimA genotypes II, Ib, and IV to be associated with disease (periodontitis and cardiovascular disease)"
] | [
"genotypes II",
"genotypes Ib",
"genotypes IV"
] | [
" FimA has been characterized as an important virulence factor for P. gingivalis, and many studies, both animal experiments and clinical investigations, have characterized fimA genotypes II, Ib, and IV to be associated with disease (periodontitis and cardiovascular disease) ",
"Long fimbriae (FimA) are important ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22549664",
"http://www.ncbi.nlm.nih.gov/pubmed/20219603",
"http://www.ncbi.nlm.nih.gov/pubmed/22466890",
"http://www.ncbi.nlm.nih.gov/pubmed/23264452",
"http://www.ncbi.nlm.nih.gov/pubmed/26387644",
"http://www.ncbi.nlm.nih.gov/pubmed/22053966",
"http://www.ncbi.nlm.n... | [] | [] |
588485bbe56acf517600000b | yesno | Is rucaparib used for ovarian cancer treatment? | [
"Yes, rucaparib is a PARP inhibitor that is used for ovarian cancer treatment."
] | [
"yes"
] | [
"While olaparib is the first PARP inhibitor to receive approval for ovarian cancer treatment, others including rucaparib and niraparib are clearly effective in this disease and, within the next year or two, the results of ongoing randomised trials will clarify their respective roles. ",
"Similar trials with other... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24962512",
"http://www.ncbi.nlm.nih.gov/pubmed/27141070",
"http://www.ncbi.nlm.nih.gov/pubmed/27087632",
"http://www.ncbi.nlm.nih.gov/pubmed/27940438",
"http://www.ncbi.nlm.nih.gov/pubmed/26281686",
"http://www.ncbi.nlm.nih.gov/pubmed/27141062",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013812",
"http://www.disease-ontology.org/api/metadata/DOID:2394",
"http://www.disease-ontology.org/api/metadata/DOID:4001",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D024221"
] |
588533cee56acf5176000014 | summary | What is the role of cohesins at the IFNG locus? | [
"Cohesins form cell-type-specific long-range chromosomal cis-interactions at the developmentally regulated IFNG locus. Hence, the ability of cohesin to constrain chromosome topology is used not only for the purpose of sister chromatid cohesion, but also to dynamically define the spatial conformation of specific loc... | [] | [
"Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus.",
"Here we show that cohesin forms the topological and mechanistic basis for cell-type-specific long-range chromosomal interactions in cis at the developmentally regulated cytokine locus IFNG. Hence, the ability of cohesin to... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19458616"
] | [] | [
"http://www.uniprot.org/uniprot/IFNG_NUMME",
"http://www.uniprot.org/uniprot/IFNG_PHOSU",
"http://www.uniprot.org/uniprot/IFNG_PHACO",
"http://www.uniprot.org/uniprot/IFNG_PAPAN",
"http://www.uniprot.org/uniprot/IFNG_LAMGL",
"http://www.uniprot.org/uniprot/IFNG_RABIT",
"http://www.uniprot.org/uniprot/IF... |
589a246578275d0c4a00002e | summary | Describe Wellens' Syndrome. | [
"Wellens Syndrome (WS) is a condition characterized by typical changes in ECG, which are biphasic T-wave inversions (less common) or symmetric and deeply inverted T waves (including 75%) in lead V2-V3 chest derivations."
] | [] | [
"NTRODUCTION: Wellens Syndrome (WS) is a condition characterized by typical changes in ECG, which are biphasic T-wave inversions (less common) or symmetric and deeply inverted T waves (including 75%) in lead V2-V3 chest derivations. ",
"BACKGROUND: Reperfusion after coronary occlusion (myocardial infarction, MI),... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27609724",
"http://www.ncbi.nlm.nih.gov/pubmed/23420731",
"http://www.ncbi.nlm.nih.gov/pubmed/21106319",
"http://www.ncbi.nlm.nih.gov/pubmed/12442245",
"http://www.ncbi.nlm.nih.gov/pubmed/16380872",
"http://www.ncbi.nlm.nih.gov/pubmed/27951539",
"http://www.ncbi.nlm.n... | [] | [] |
58bc5e2202b8c60953000002 | factoid | Which human disease is associated with mutated UBQLN2 | [
"Ggene mutations in UBQLN2 cause dominant inheritance of amyotrophic lateral sclerosis (ALS)."
] | [
"ALS",
"amyotrophic lateral sclerosis"
] | [
"Finally, we found that mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice.",
"UBQLN2 mutations are detected in ALS cases.",
"C9ORF72 and UBQLN2 mutations are causes of amyotrophic lateral sclerosis... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27400686",
"http://www.ncbi.nlm.nih.gov/pubmed/27480424",
"http://www.ncbi.nlm.nih.gov/pubmed/25398946",
"http://www.ncbi.nlm.nih.gov/pubmed/26075709",
"http://www.ncbi.nlm.nih.gov/pubmed/27834214",
"http://www.ncbi.nlm.nih.gov/pubmed/27477512"
] | [] | [] |
58b6bd2622d300530900000c | factoid | Which ApoE isoform is associated with hyperlipoproteinemia? | [
"Type III hyperlipoproteinemia (HLP) is characterized by the accumulation of remnant lipoproteins in the plasma and it is associated with ApoE2 isoform. ApoE2 binds poorly to low density lipoprotein receptors, resulting in defective remnant lipoprotein clearance."
] | [
"ApoE2 isoform",
"Apolipoprotein E2 isoform"
] | [
"ApoE2 which differs from apoE3 by the single amino acid substitution Arg158Cys located near the LDLR recognition site exhibits impaired binding to the receptor and an inability to promote clearance of TG-rich lipoprotein remnant particles; this isoform is associated with Type-III hyperlipoproteinemia. ",
"Type I... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18823563",
"http://www.ncbi.nlm.nih.gov/pubmed/8175773",
"http://www.ncbi.nlm.nih.gov/pubmed/11163021",
"http://www.ncbi.nlm.nih.gov/pubmed/2609136",
"http://www.ncbi.nlm.nih.gov/pubmed/11701639",
"http://www.ncbi.nlm.nih.gov/pubmed/15630629",
"http://www.ncbi.nlm.nih... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006951",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053329",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006952",
"http://www.disease-ontology.or... |
58b9585c22d3005309000010 | yesno | Could hypophosphatemic rickets cause craniosynostosis? | [
"Yes, hypophosphatemic rickets could cause craniosynostosis."
] | [
"yes"
] | [
"This study examines a series of patients with hypophosphatemic rickets and craniosynostosis to characterize the clinical course and associated craniofacial anomalies. ",
"Hypophosphatemic rickets and craniosynostosis: a multicenter case series.",
"A 20-year retrospective review identified patients with hypopho... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26824597",
"http://www.ncbi.nlm.nih.gov/pubmed/22220162",
"http://www.ncbi.nlm.nih.gov/pubmed/26510652",
"http://www.ncbi.nlm.nih.gov/pubmed/23466123",
"http://www.ncbi.nlm.nih.gov/pubmed/23348263",
"http://www.ncbi.nlm.nih.gov/pubmed/19242361",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005624",
"http://www.disease-ontology.org/api/metadata/DOID:2340",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012279",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find... |
589a246878275d0c4a000030 | yesno | Is vortioxetine effective for treatment of depression? | [
"Yes. Vortioxetine is the most recently approved medication for the treatment of major depressive disorder."
] | [
"yes"
] | [
"Vortioxetine is the most recently approved medication for the treatment of major depressive disorder (MDD). ",
"[Vortioxetine: a new antidepressant to treat depressive episodes].",
"Vortioxetine is a new antidepressant, which mechanism of action is multimodal, targeting the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3, 5-HT7... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26346592",
"http://www.ncbi.nlm.nih.gov/pubmed/25249164",
"http://www.ncbi.nlm.nih.gov/pubmed/25851751",
"http://www.ncbi.nlm.nih.gov/pubmed/26525043",
"http://www.ncbi.nlm.nih.gov/pubmed/26546771",
"http://www.ncbi.nlm.nih.gov/pubmed/24787143",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003863",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003866"
] |
589480b47d9090f353000007 | factoid | Which server is used for simulation of macromolecular diffusional association? | [
"Macromolecular interactions play a crucial role in biological systems. Simulation of diffusional association (SDA) is a software for carrying out Brownian dynamics simulations that can be used to study the interactions between two or more biological macromolecules. webSDA allows users to run Brownian dynamics simu... | [
"webSDA"
] | [
"webSDA: a web server to simulate macromolecular diffusional association.",
"Macromolecular interactions play a crucial role in biological systems. Simulation of diffusional association (SDA) is a software for carrying out Brownian dynamics simulations that can be used to study the interactions between two or mor... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25883142"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056004",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003198",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D039301"
] |
58bca1c202b8c6095300000b | yesno | Can beans induce apoptosis? | [
"White kidney bean lectin has been shown to exert anti-proliferative and apoptotic effects on cancer cells"
] | [
"yes"
] | [
"A 60-kDa glucosamine binding lectin, white kidney bean lectin (WKBL), was purified from Phaseolus vulgaris cv. white kidney beans, by application of anion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel blue gel, and FPLC-size exclusion on Superdex 75. The anti-proliferative activity of... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24952025",
"http://www.ncbi.nlm.nih.gov/pubmed/15302513",
"http://www.ncbi.nlm.nih.gov/pubmed/23194196",
"http://www.ncbi.nlm.nih.gov/pubmed/25997867",
"http://www.ncbi.nlm.nih.gov/pubmed/23027830",
"http://www.ncbi.nlm.nih.gov/pubmed/19723093",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017209"
] |
58b6a42522d300530900000b | summary | What is the function of transthyretin in cerebrospinal fluid? | [
"Transthyretin (TTR) is a protein synthesized in the choroid plexus, which forms the blood-cerebrospinal fluid barrier. TTR is the physiological carrier of thyroxine (T4) and retinol from the blood into the cerebrospinal fluid and their distribution in the brain. The transport of T4 is important for normal develop... | [] | [
"Transthyretin (TTR) is a protein that binds and distributes thyroid hormones (THs). TTR synthesised in the liver is secreted into the bloodstream and distributes THs around the body, whereas TTR synthesised in the choroid plexus is involved in movement of thyroxine from the blood into the cerebrospinal fluid and t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25737004",
"http://www.ncbi.nlm.nih.gov/pubmed/16325339",
"http://www.ncbi.nlm.nih.gov/pubmed/25311081",
"http://www.ncbi.nlm.nih.gov/pubmed/7965021",
"http://www.ncbi.nlm.nih.gov/pubmed/24160776",
"http://www.ncbi.nlm.nih.gov/pubmed/25009532",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.uniprot.org/uniprot/TTHY_MACEU",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002555",
"http://www.uniprot.org/uniprot/TTHY_MACGI",
"http://www.uniprot.org/uniprot/TTHY_TILRU",
"http://www.uniprot.org/uniprot/TTHY_PIG",
"http://www.uniprot.org/uniprot/TTH... |
58a342e760087bc10a00001c | factoid | Can you define iatrogenic disease? | [
"An iatrogenic disease is one that arises from treatment of another illness, such as an arrythmia that results from surgery or and hospital aquired infection in an immunocompromised patient."
] | [
"illness caused by treatment"
] | [
"Iatrogenic neurologic deficits after lumbar spine surgery are rare complications, but important to recognize and manage.",
"However, we analyze its etiology in order to determine if it is from iatrogenic causes. This syndrome can be categorized as follows: mistaken diagnoses, transoperative error, technique erro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21610562",
"http://www.ncbi.nlm.nih.gov/pubmed/26767158",
"http://www.ncbi.nlm.nih.gov/pubmed/10979347",
"http://www.ncbi.nlm.nih.gov/pubmed/25660151",
"http://www.ncbi.nlm.nih.gov/pubmed/19063792",
"http://www.ncbi.nlm.nih.gov/pubmed/2173098",
"http://www.ncbi.nlm.ni... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007049"
] |
58b56fe422d3005309000007 | factoid | Where do the Schwann cells and melanocytes originate from? | [
"Schwann cells and melanocytes originate from the multipotent population of neural crest cells."
] | [
"neural crest cells",
"NCC"
] | [
"The development of the nervous system involves cells remaining within the neural tube (CNS) and a group of cells that delaminate from the dorsal neural tube and migrate extensively throughout the developing embryo called neural crest cells (NCC). These cells are a mesenchymal highly migratory group of cells that g... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24760871",
"http://www.ncbi.nlm.nih.gov/pubmed/17652534",
"http://www.ncbi.nlm.nih.gov/pubmed/21501576",
"http://www.ncbi.nlm.nih.gov/pubmed/8834474",
"http://www.ncbi.nlm.nih.gov/pubmed/23858437",
"http://www.ncbi.nlm.nih.gov/pubmed/9142492",
"http://www.ncbi.nlm.nih... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008544",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012583",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D039904",
"https://www.nlm.nih.gov/cgi/me... |
58bd645702b8c60953000010 | list | Please list 3 diseases associated with the PIEZO2 gene. | [
"Recently, Gordon syndrome has been associated to heterozygous mutations in the piezo-type mechanosensitive ion channel component 2 gene (PIEZO2). Different mutations of this gene also cause distal arthrogryposis type 5 and Marden-Walker syndrome."
] | [
"Gordon syndrome",
"distal arthrogryposis type 5",
"Marden-Walker syndrome"
] | [
"Recently, Gordon syndrome has been associated to heterozygous mutations in the piezo-type mechanosensitive ion channel component 2 gene (PIEZO2). Different mutations of this gene also cause distal arthrogryposis type 5 and Marden-Walker syndrome.",
"Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndro... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24726473",
"http://www.ncbi.nlm.nih.gov/pubmed/27843126",
"http://www.ncbi.nlm.nih.gov/pubmed/27714920",
"http://www.ncbi.nlm.nih.gov/pubmed/23487782"
] | [] | [
"http://www.uniprot.org/uniprot/PIEZ2_HUMAN"
] |
58a337af60087bc10a000016 | yesno | Is treatment resistant depression related to vitamin B9? | [
"Treatment with SAMe, as well as with various formulations of folates and analogues, appears to be efficacious and well tolerated in reducing depressive symptoms in treatment resistant depression."
] | [
"yes"
] | [
"Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This article reviews the evidence for L-methylfolate and folic acid as antidepressive agent... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25229175",
"http://www.ncbi.nlm.nih.gov/pubmed/22762295",
"http://www.ncbi.nlm.nih.gov/pubmed/27655070",
"http://www.ncbi.nlm.nih.gov/pubmed/24324965",
"http://www.ncbi.nlm.nih.gov/pubmed/23538072",
"http://www.ncbi.nlm.nih.gov/pubmed/24519190",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003863",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D061218",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003865"
] |
58a87bd338c171fb5b000005 | summary | Where is the protein slitrk1 localized? | [
"Slitrk1 is enriched in postsynaptic fractions and is localized to excitatory synapses. "
] | [] | [
"Slitrk1 is localized to excitatory synapses",
" Slitrk1 is enriched in postsynaptic fractions and is localized to excitatory synapses.",
" The porcine SLITRK1 gene is expressed exclusively in brain tissues.",
"Six family members exist (Slitrk1-6) and all are highly expressed in the central nervous system (CN... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25379384",
"http://www.ncbi.nlm.nih.gov/pubmed/21315458",
"http://www.ncbi.nlm.nih.gov/pubmed/22703893",
"http://www.ncbi.nlm.nih.gov/pubmed/27273464"
] | [] | [] |
5895db407d9090f35300000e | summary | Describe clinical manifestation of the Harlequin syndrome. | [
"Harlequin syndrome is characterized by the sudden onset of unilateral facial flushing and sweating, often preceded by exercise, excessive heat, or, rarely, regional anesthesia. It is a rare autonomic disorder due to a hemifacial cutaneous sympathetic denervation."
] | [] | [
"Harlequin syndrome is characterized by the sudden onset of unilateral facial flushing and sweating, often preceded by exercise, excessive heat, or, rarely, regional anesthesia. ",
"UNLABELLED: Harlequin syndrome (HS) is a rare autonomic disorder due to a hemifacial cutaneous sympathetic denervation. It is charac... | [
"http://www.ncbi.nlm.nih.gov/pubmed/9555141",
"http://www.ncbi.nlm.nih.gov/pubmed/18769278",
"http://www.ncbi.nlm.nih.gov/pubmed/16918633",
"http://www.ncbi.nlm.nih.gov/pubmed/21796071",
"http://www.ncbi.nlm.nih.gov/pubmed/23726525",
"http://www.ncbi.nlm.nih.gov/pubmed/8292878",
"http://www.ncbi.nlm.nih... | [] | [] |
58b576b622d3005309000008 | summary | What is the role of the constitutive photomorphogenesis 9 signalosome (CSN)? | [
"The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is a protein complex involved in the ubiquitin proteasome system and plays a role in regulating the degradation of polyubiquitinated proteins. The mammalian CSN is also involved in embryonic development, in cancer and the DNA damage response, whereas i... | [] | [
"The family of cullin-RING E3 Ligases (CRLs) and the constitutive photomorphogenesis 9 (COP9) signalosome (CSN) form dynamic complexes that mediate ubiquitylation of 20% of the proteome, yet regulation of their assembly/disassembly remains poorly understood. ",
"The COP9 (constitutive photomorphogenesis 9) signal... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27412572",
"http://www.ncbi.nlm.nih.gov/pubmed/18854373",
"http://www.ncbi.nlm.nih.gov/pubmed/11731421",
"http://www.ncbi.nlm.nih.gov/pubmed/27581057",
"http://www.ncbi.nlm.nih.gov/pubmed/23818606",
"http://www.ncbi.nlm.nih.gov/pubmed/16844902",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012380",
"http://amigo.geneontology.org/amigo/term/GO:0008180"
] |
58847e36e56acf5176000009 | yesno | Is adalimumab effective for hidradenitis suppurativa? | [
"Yes, Adalimumab, a recombinant, fully humanized, anti-tumor necrosis factor alpha (anti-TNF-α) monoclonal antibody, is the only officially approved treatment for the management of moderate-to-severe hidradenitis suppurativa."
] | [
"yes"
] | [
"If patient is not improved, then Adalimumab 160 mg at week 0, 80 mg at week 2; then 40 mg subcutaneously weekly should be administered (LOE Ib, SOR A). If improvement occurs then therapy should be maintained as long as HS lesions are present.",
"Reduction in pain scores and improvement in depressive symptoms in ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25580790",
"http://www.ncbi.nlm.nih.gov/pubmed/26470624",
"http://www.ncbi.nlm.nih.gov/pubmed/26201313",
"http://www.ncbi.nlm.nih.gov/pubmed/26831295",
"http://www.ncbi.nlm.nih.gov/pubmed/18754844",
"http://www.ncbi.nlm.nih.gov/pubmed/27665300",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:2280",
"http://www.biosemantics.org/jochem#4002010",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000068879",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017497"
] |
58bc8e5002b8c60953000006 | summary | What is Legg-Calvé-Perthes Disease | [
"Legg-Calve-Perthes disease is idiopathic avascular necrosis of the hip, usually occurring in pediatric populations.",
"Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. Legg-Calve-Perthes disease (LCPD) is the insidious o... | [] | [
"Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. The etiology of the disease remains largely unknown, but the me",
"Legg-Calve-Perthes disease (LCPD) is the insidious onset of idiopathic avascular necrosis of the hip in t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27064472",
"http://www.ncbi.nlm.nih.gov/pubmed/26780125",
"http://www.ncbi.nlm.nih.gov/pubmed/12208918",
"http://www.ncbi.nlm.nih.gov/pubmed/21606991",
"http://www.ncbi.nlm.nih.gov/pubmed/20048104"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:14415",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007873"
] |
588800f43b87a8a738000009 | summary | What is promoted by ERAP1-ERAP2 dimerization? | [
"ERAP1-ERAP2 dimerization increases peptide-trimming efficiency.",
"ERAP1-ERAP2 dimerization increases peptide-trimming efficiency. ERAP1-ERAP2 heterodimers produce several mature epitopes more efficiently than a mix of the two enzymes unable to dimerize. Physical interaction with ERAP2 changes basic enzymatic pa... | [] | [
"ERAP1-ERAP2 dimerization increases peptide-trimming efficiency.",
"In this study, we produced stabilized ERAP1-ERAP2 heterodimers and found that they produced several mature epitopes more efficiently than a mix of the two enzymes unable to dimerize. Physical interaction with ERAP2 changes basic enzymatic paramet... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24928998"
] | [] | [
"http://www.uniprot.org/uniprot/ERAP1_RAT",
"http://www.uniprot.org/uniprot/ERAP1_HUMAN",
"http://www.uniprot.org/uniprot/ERAP2_PONAB",
"http://www.uniprot.org/uniprot/ERAP2_HUMAN",
"http://www.uniprot.org/uniprot/ERAP2_BOVIN",
"http://www.uniprot.org/uniprot/ERAP1_MOUSE"
] |
58bc8e7a02b8c60953000007 | factoid | What is plantar fasciitis | [
"Plantar fascia (PF) disorders like plantar fasciitis commonly cause heel pain and disability and are thought to be degenerative rather than inflammatory in nature"
] | [
"heel pain"
] | [
"Plantar fascia (PF) disorders commonly cause heel pain and disability",
"Plantar fasciitis (PF) is a common foot complaint, affects both active sportsmen and physically inactive middle age group. It is believed that PF results from degenerative changes rather than inflammation",
"Plantar fasciitis (PF) is pres... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26655866",
"http://www.ncbi.nlm.nih.gov/pubmed/26184993",
"http://www.ncbi.nlm.nih.gov/pubmed/26665894",
"http://www.ncbi.nlm.nih.gov/pubmed/25429080",
"http://www.ncbi.nlm.nih.gov/pubmed/23037146",
"http://www.ncbi.nlm.nih.gov/pubmed/21272731",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005208",
"http://www.disease-ontology.org/api/metadata/DOID:9598",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D036981",
"http://www.disease-ontology.org/api/metadata/DOID:9600"
] |
58a9a8631978bbde22000003 | factoid | Which is the enzymatic activity of OTULIN? | [
"OTULIN is a deubiquitinase, that specifically cleaves Met1-linked polyUb."
] | [
"deubiquitination"
] | [
"deubiquitinase OTULIN",
"OTULIN (FAM105B), encoding a deubiquitinase ",
" Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.",
"Removal of ubiquitin chains is mediated by deubiquitinases (DUBs). Two of them, OTULIN and CYLD, ",
" are disassembled by the linear ubiquitin-specif... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26503766",
"http://www.ncbi.nlm.nih.gov/pubmed/23746843",
"http://www.ncbi.nlm.nih.gov/pubmed/24461064",
"http://www.ncbi.nlm.nih.gov/pubmed/24726327",
"http://www.ncbi.nlm.nih.gov/pubmed/26235645",
"http://www.ncbi.nlm.nih.gov/pubmed/26085216",
"http://www.ncbi.nlm.n... | [] | [] |
58bc666702b8c60953000004 | list | List diseases that could be targeted by disaggregases? | [
"UBQLN2 acts with the HSP70-HSP110 disaggregase machinery to clear protein aggregates via the 26S proteasome. UBQLN2 recognizes client-bound HSP70 and links it to the proteasome to allow for the degradation of aggregated and misfolded proteins. We further show that this process is active in the cell nucleus, where ... | [
"ALS",
"amyotrophic lateral sclerosis",
"PD",
"Parkinson's disease",
"AD",
"Alzheimer's disease",
"Prions"
] | [
"Therapeutic agents are urgently required to cure several common and fatal neurodegenerative disorders caused by protein misfolding and aggregation, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD).",
"Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synu... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27255695",
"http://www.ncbi.nlm.nih.gov/pubmed/26312418",
"http://www.ncbi.nlm.nih.gov/pubmed/25620563",
"http://www.ncbi.nlm.nih.gov/pubmed/26300264"
] | [] | [] |
5886222a3b87a8a738000005 | yesno | Can NEECHAM Confusion Scale be used for evaluation of postoperative delirium? | [
"Yes, NEECHAM Confusion Scale can be used for evaluation of postoperative delirium."
] | [
"yes"
] | [
"Sampling was achieved in a nonrandomized targeted manner and delirium was assessed using NeeCham questionnaire. ",
"Delirium in older patients: a diagnostic study of NEECHAM Confusion Scale in surgical intensive care unit.",
"AIMS AND OBJECTIVES: To estimate the diagnostic value and determine the feasibility o... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24175169",
"http://www.ncbi.nlm.nih.gov/pubmed/16732742",
"http://www.ncbi.nlm.nih.gov/pubmed/18282269",
"http://www.ncbi.nlm.nih.gov/pubmed/25337310",
"http://www.ncbi.nlm.nih.gov/pubmed/23121489",
"http://www.ncbi.nlm.nih.gov/pubmed/10701282",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D023362",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003693",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000067290",
"https://www.nlm.nih.gov/cgi... |
58bca3eb02b8c6095300000d | summary | What is adhesive capsulitis | [
"Adhesive capsulitis also known as \"frozen shoulder\" is characterized by painful, gradual loss of active and passive shoulder motion resulting from fibrosis and contracture of the joint capsule."
] | [] | [
"Adhesive capsulitis (frozen shoulder) is a common cause of shoulder pain and disability",
"Adhesive capsulitis is characterized by painful, gradual loss of active and passive shoulder motion resulting from fibrosis and contracture of the joint capsule.",
"Painful stiffening of the shoulder, 'frozen shoulder' i... | [
"http://www.ncbi.nlm.nih.gov/pubmed/2702506",
"http://www.ncbi.nlm.nih.gov/pubmed/27942856",
"http://www.ncbi.nlm.nih.gov/pubmed/25919473",
"http://www.ncbi.nlm.nih.gov/pubmed/19011582",
"http://www.ncbi.nlm.nih.gov/pubmed/21885699",
"http://www.ncbi.nlm.nih.gov/pubmed/19589853",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:14188"
] |
587d36ab859bf79568000001 | summary | Describe the applicability of Semantic MediaWiki in the case of FANTOM5 | [
"To make the heterogeneous data set accessible and useful for investigators, a web-based database called Semantic catalog of Samples, Transcription initiation And Regulators (SSTAR) has been developed. SSTAR utilizes the open source wiki software MediaWiki along with the Semantic MediaWiki (SMW) extension, which pr... | [] | [
"To make the heterogeneous data set accessible and useful for investigators, we developed a web-based database called Semantic catalog of Samples, Transcription initiation And Regulators (SSTAR). SSTAR utilizes the open source wiki software MediaWiki along with the Semantic MediaWiki (SMW) extension, which provides... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27402679"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012660",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D059467"
] |
5895ec5e7d9090f353000015 | yesno | Is there an association between Muenke Syndrome and FGFR3 gene mutation? | [
"Yes, Muenke syndrome is caused by point mutation (C749G) in the Fibroblast Growth Factor Receptor3 (FGFR3) gene. It affects 1 in 30,000 newborns and accounts for 25% to 30% of genetic causes of craniosynostosis."
] | [
"yes"
] | [
"RESULTS: Forty-four with a positive FGFR3 mutation, median age 9 years, range 7 months to 52 years were enrolled. In addition, 10 unaffected siblings served as controls (5 males, 5 females; median age, 13 years; range, 3-18 years).",
"Muenke is a fibroblast growth factor receptor 3 (FGFR-3)-associated syndrome, ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17103449",
"http://www.ncbi.nlm.nih.gov/pubmed/11571861",
"http://www.ncbi.nlm.nih.gov/pubmed/21403557",
"http://www.ncbi.nlm.nih.gov/pubmed/22872265",
"http://www.ncbi.nlm.nih.gov/pubmed/21233754",
"http://www.ncbi.nlm.nih.gov/pubmed/10696568",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/FGFR3_CHICK",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001244",
"http://www.disease-ontology.org/api/metadata/DOID:0060703",
"http://www.uniprot.org/uniprot/FGFR3_PLEWA",
"http://www.uniprot.org/uniprot/FGFR3_HUMAN",
"https://www.n... |
588f2de394c1512c50000001 | factoid | Which R package is used for visualization of linear and circular karyotypes? | [
"The chromDraw graphical tool was developed as a user-friendly graphical tool for visualizing both linear and circular karyotypes based on the same input data matrix. The output graphics, saved in two different formats (EPS and SVG), can be easily imported to and modified in presentation and image-editing computer ... | [
"chromDraw"
] | [
"chromDraw: an R package for visualization of linear and circular karyotypes.",
"The chromDraw graphical tool was developed as a user-friendly graphical tool for visualizing both linear and circular karyotypes based on the same input data matrix. The output graphics, saved in two different formats (EPS and SVG), ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26791998"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D059785"
] |
58a1da4e78275d0c4a000059 | yesno | Has small pox been eradicated from the world? | [
"smallpox is now eradicated.",
"Yes, small pox has been eradicated.",
"smallpox is now eradicated",
"small pox has been eradicated."
] | [
"yes"
] | [
"small pox has been eradicated.",
"smallpox is now eradicated",
"In May 1980 the World Health Assembly in Geneva announced in solemn form the world-wide eradication of the small-pox and gave recommendations to the member countries for concluding measures concerning the small-pox vaccination, the foundation of v... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22566811",
"http://www.ncbi.nlm.nih.gov/pubmed/11808015",
"http://www.ncbi.nlm.nih.gov/pubmed/10742580",
"http://www.ncbi.nlm.nih.gov/pubmed/14969309",
"http://www.ncbi.nlm.nih.gov/pubmed/23436190",
"http://www.ncbi.nlm.nih.gov/pubmed/7013291",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:8736",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012899",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012900"
] |
58bc363622d300530900001f | factoid | Where is Akkermansia muciniphila found? | [
"Akkermansia muciniphila is a Gram-negative mucin-degrading bacterium that resides in the gastrointestinal tracts of humans and animals.",
"RYGB led to altered relative abundances of 31 species (P < 0.05, q < 0.15) within the first 3 months, including those of Escherichia coli, Klebsiella pneumoniae, Veillonella ... | [
"Akkermansia muciniphila resides in the gastrointestinal tracts of humans and animals."
] | [
"Akkermansia muciniphila is a Gram-negative mucin-degrading bacterium that resides in the gastrointestinal tracts of humans and animals. ",
"Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abunda... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25795669",
"http://www.ncbi.nlm.nih.gov/pubmed/26100928"
] | [] | [] |
58963b0278275d0c4a00000c | yesno | Is there alternative polyadenylation during zebrafish development? | [
"Yes. There is extensive alternative polyadenylation during zebrafish development."
] | [
"yes"
] | [
"Extensive alternative polyadenylation during zebrafish development.",
"At 2 h post-fertilization, thousands of unique poly(A) sites appear at locations lacking a typical polyadenylation signal, which suggests a wave of widespread cytoplasmic polyadenylation of mRNA degradation intermediates. Our insights into th... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22722342"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D026723",
"http://amigo.geneontology.org/amigo/term/GO:1900365",
"http://amigo.geneontology.org/amigo/term/GO:1900364",
"http://amigo.geneontology.org/amigo/term/GO:1900363",
"http://amigo.geneontology.org/amigo/term/GO:00063... |
58a5a51060087bc10a000021 | factoid | Which NADPH oxidase family member requires interaction with NOXO1 for function? | [
"NADPH oxidase 1 (NOX1) requires interaction with NOXO1 for function."
] | [
"NADPH oxidase 1",
"NOX1",
"nicotinamide adenine dinucleotide phosphate-oxidase 1"
] | [
"A unique member of this family, Nox1 oxidase, functions as either a canonical or hybrid system using Nox organizing subunit 1 (NoxO1) or p47(phox), respectively, the latter of which is functional in vascular smooth muscle cells (VSMC). ",
"Phosphorylation of Noxo1 at threonine 341 regulates its interaction with ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18929641",
"http://www.ncbi.nlm.nih.gov/pubmed/15507761",
"http://www.ncbi.nlm.nih.gov/pubmed/15507762",
"http://www.ncbi.nlm.nih.gov/pubmed/15824103",
"http://www.ncbi.nlm.nih.gov/pubmed/27540115",
"http://www.ncbi.nlm.nih.gov/pubmed/17900370",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/NOXO1_HUMAN",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019255",
"http://www.uniprot.org/uniprot/NOXO1_MOUSE",
"http://amigo.geneontology.org/amigo/term/GO:0043020",
"http://www.biosemantics.org/jochem#4270191",
"http://www.uniprot.... |
587e276be96a600607000001 | yesno | Are alterations in ultraconserved elements implicated in breast cancer? | [
"Yes. SNPs in ultraconserved elements (UCEs) might be associated with cancer risk."
] | [
"yes"
] | [
"SNPs in ultraconserved elements and familial breast cancer risk",
" In the present study, we investigated the influence of six SNPs within UCEs on familial breast cancer risk. Two out of six SNPs showed an association with familial breast cancer risk",
"This is the first study indicating that SNPs in UCEs migh... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18174240",
"http://www.ncbi.nlm.nih.gov/pubmed/21331621"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001943",
"http://www.disease-ontology.org/api/metadata/DOID:0060548",
"http://www.disease-ontology.org/api/metadata/DOID:1612",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000069584",
... |
58848822e56acf517600000c | summary | What is the mechanism of action of Osimertinib? | [
"Osimertinib is a third-generation irreversible tyrosine kinase inhibitor of both activating EGFR mutations and resistance-associated T790M point mutation."
] | [] | [
"In addition, mutations leading to resistance to first-line EGFR and ALK TKIs can now be successfully inhibited by soon to be approved third-generation EGFR TKIs (osimertinib, rociletinib) and second-generation ALK TKIs (ceritinib, alectinib). ",
"Gefitinib, erlotinib, and afatinib are the EGFR tyrosine kinase in... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27861144",
"http://www.ncbi.nlm.nih.gov/pubmed/27393507",
"http://www.ncbi.nlm.nih.gov/pubmed/27923714",
"http://www.ncbi.nlm.nih.gov/pubmed/26902828",
"http://www.ncbi.nlm.nih.gov/pubmed/27169328",
"http://www.ncbi.nlm.nih.gov/pubmed/27835594",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020228",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D045504"
] |
58bcb83d02b8c6095300000f | summary | What is Bartter syndrome? | [
"All forms of Bartter syndrome are characterized by hypokalemia, metabolic alkalosis, and secondary hyperaldosteronism",
"All forms of hereditary Bartter syndrome are characterized by hypokalemia, metabolic alkalosis, and secondary hyperaldosteronism."
] | [] | [
"All forms of Bartter syndrome are characterized by hypokalemia, metabolic alkalosis, and secondary hyperaldosteronism",
"The mutations in the CLCNKB gene encoding the ClC-Kb chloride channel are responsible for Bartter syndrome type 3, one of the four variants of Bartter syndrome in the genetically based nomencl... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25810436",
"http://www.ncbi.nlm.nih.gov/pubmed/23164417",
"http://www.ncbi.nlm.nih.gov/pubmed/18800266",
"http://www.ncbi.nlm.nih.gov/pubmed/9203176",
"http://www.ncbi.nlm.nih.gov/pubmed/9502562",
"http://www.ncbi.nlm.nih.gov/pubmed/1328936",
"http://www.ncbi.nlm.nih.... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:0110147",
"http://www.disease-ontology.org/api/metadata/DOID:0110146",
"http://www.disease-ontology.org/api/metadata/DOID:0110145",
"http://www.disease-ontology.org/api/metadata/DOID:0110144",
"http://www.disease-ontology.org/api/metadata/DOID:0110143",
"... |
588f5e9994c1512c50000004 | yesno | Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish? | [
"Yes. The zebrafish enhancer detection (ZED) vector is a tool that facilitates transgenesis and the functional analysis of cis-regulatory regions in zebrafish."
] | [
"yes"
] | [
"Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish.",
"he cis-regulatory sequences control when, where, and how much genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. Here, we... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19653328"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004742",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015027",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011401",
"https://www.nlm.nih.gov/cgi/me... |
58bbb71f22d3005309000016 | list | List RNA modifications databases | [
"RMBase and MODOMICS"
] | [
"RMBase",
"RNA Modification Base",
"MODOMICS"
] | [
"RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data.",
"we developed a novel resource, RMBase (RNA Modification Base, http://mirlab.sysu.edu.cn/rmbase/), to decode the genome-wide landscape of RNA modifications identified from high-throughput modification data ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26464443",
"http://www.ncbi.nlm.nih.gov/pubmed/27016142",
"http://www.ncbi.nlm.nih.gov/pubmed/23118484"
] | [] | [] |
58bc9a5002b8c60953000008 | list | Please list the 3 findings in HELLP syndrome. | [
"hemolysis, elevated liver enzymes and low platelets constitute the hellp syndrome.",
"HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) is an obstetric complication and is characterized by microangiopathic hemolytic anemia, elevated liver enzymes by intravascular breakdown of fibrin in hepatic si... | [
"hemolytic anemia",
"elevated liver enzymes",
"low platlets"
] | [
"HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) is an obstetric complication with heterogonous presentation and multisystemic involvement. It is characterized by microangiopathic hemolytic anemia, elevated liver enzymes by intravascular breakdown of fibrin in hepatic sinusoids and reduction of pl... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26953551",
"http://www.ncbi.nlm.nih.gov/pubmed/11854637",
"http://www.ncbi.nlm.nih.gov/pubmed/23871223",
"http://www.ncbi.nlm.nih.gov/pubmed/11720149",
"http://www.ncbi.nlm.nih.gov/pubmed/23040928",
"http://www.ncbi.nlm.nih.gov/pubmed/8765269",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:13133",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017359"
] |
58a57f9460087bc10a00001f | factoid | Which mutated gene is associated with Waardenburg and Tietz syndromes? | [
"Mutations in microphthalmia-associated transcription factor (MITF) gene cause Waardenburg and Tietz syndromes."
] | [
"microphthalmia-associated transcription factor gene",
"MITF"
] | [
"Tietz/Waardenburg type 2A syndrome associated with posterior microphthalmos in two unrelated patients with novel MITF gene mutations.",
"Tietz syndrome and Waardenburg syndrome type 2A are allelic conditions caused by MITF mutations. ",
"For example, mutations of the MITF gene cause Waardenburg syndrome type 2... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10952390",
"http://www.ncbi.nlm.nih.gov/pubmed/22371403",
"http://www.ncbi.nlm.nih.gov/pubmed/24379252",
"http://www.ncbi.nlm.nih.gov/pubmed/23098757",
"http://www.ncbi.nlm.nih.gov/pubmed/22258527",
"http://www.ncbi.nlm.nih.gov/pubmed/23020089",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005796",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051739",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"https://www.nlm.nih.gov/cgi/me... |
58bbbe6822d300530900001a | list | List the three most abundant bacterial phyla present in mouse feces. | [
"Firmicutes\nProteobacteria \nBacteroidetes"
] | [
"Firmicutes",
"Proteobacteria",
"Bacteroidetes"
] | [
"Amplicons representing the major phyla encountered in the rumen (Firmicutes, 43.7%; Proteobacteria, 28.7%; Bacteroidetes, 25.3%; Spirochea, 1.1%, and Synergistes, 1.1%) were recovered, ",
"alterations in the gut microbiota (increased Firmicutes and decreased Bacteroidetes)",
"The taxonomic analysis of the meta... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25537565",
"http://www.ncbi.nlm.nih.gov/pubmed/20926643",
"http://www.ncbi.nlm.nih.gov/pubmed/23457582",
"http://www.ncbi.nlm.nih.gov/pubmed/19159975"
] | [] | [] |
58bcabc702b8c6095300000e | factoid | What gene is mutated in Sickle Cell Anemia? | [
"Sickle cell anemia (SCA) is an autosomal recessive disease caused by by the HBB:c.20A>T mutation that leads to hemoglobin S synthesis.",
" sca patients present clinical and hematologic variability that cannot be only explained by the single mutation in the beta-globin gene."
] | [
"HBB"
] | [
"Sickle cell anemia (SCA) is an inherited blood disorder. SCA patients present clinical and hematologic variability that cannot be only explained by the single mutation in the beta-globin gene.",
"Sickle cell anemia (SCA) is an autosomal recessive disease caused by the HBB:c.20A>T mutation that leads to hemoglobi... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27802215",
"http://www.ncbi.nlm.nih.gov/pubmed/27814292",
"http://www.ncbi.nlm.nih.gov/pubmed/17662889",
"http://www.ncbi.nlm.nih.gov/pubmed/1301951",
"http://www.ncbi.nlm.nih.gov/pubmed/11172667",
"http://www.ncbi.nlm.nih.gov/pubmed/20886046",
"http://www.ncbi.nlm.ni... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000755",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006451",
"http://www.disease-ontology.org/api/metadata/DOID:10923",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Fin... |
58b95ea222d3005309000011 | summary | What is the function of the Indian hedgehog protein in chondrocytes? | [
"Indian hedgehog is a protein that regulates endochondral differentiation and ossification in both a parathyroid hormone-related protein (PTHrP)-dependent and -independent manner by activating transcriptional mediator Gli2 and is an essential factor for proper skeletal development."
] | [] | [
"Indian hedgehog (Ihh) regulates endochondral ossification in both a parathyroid hormone-related protein (PTHrP)-dependent and -independent manner by activating transcriptional mediator Gli2. ",
"Wnt/β-catenin, Indian hedgehog (Ihh)/Parathyroid-related peptide (PTHrP) and retinoid signaling pathways regulate cart... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24821091",
"http://www.ncbi.nlm.nih.gov/pubmed/17328886",
"http://www.ncbi.nlm.nih.gov/pubmed/11517192",
"http://www.ncbi.nlm.nih.gov/pubmed/18059015",
"http://www.ncbi.nlm.nih.gov/pubmed/10328918",
"http://www.ncbi.nlm.nih.gov/pubmed/12213208",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/IHH_DANAT",
"http://www.uniprot.org/uniprot/IHH_RASEL",
"http://www.uniprot.org/uniprot/IHH_CARAU",
"http://www.uniprot.org/uniprot/IHH_TRIHE",
"http://www.uniprot.org/uniprot/IHH_DANAP",
"http://www.uniprot.org/uniprot/IHH_DEVDE",
"https://www.nlm.nih.gov/cgi/mesh/2017/M... |
5883a727e56acf5176000001 | factoid | What is the function of R-spondin 1 and noggin in non-damaged gallbladders? | [
"R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders."
] | [
"The expansion of resident stem cells."
] | [
"R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders.",
"R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/26993089"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005704",
"http://www.biosemantics.org/jochem#4264633",
"http://www.uniprot.org/uniprot/NOGG_HUMAN",
"http://www.uniprot.org/uniprot/RSPO1_MOUSE",
"http://www.uniprot.org/uniprot/RSPO1_DANRE",
"http://www.uniprot.org/unipro... |
58b53bf722d3005309000004 | list | List the classical triad of symptoms of the Melkersson–Rosenthal syndrome. | [
"The Melkersson-Rosenthal syndrome consists of the classical triad of symptoms:\n1) orofacial oedema \n2) fissured tongue (lingua plicata) and\n3) facial paralysis."
] | [
"orofacial oedema",
"lip and face swelling",
"fissured tongue",
"lingua plicata",
"facial paralysis",
"facial palsy"
] | [
"The Melkersson-Rosenthal syndrome consists of a triad of recurrent lip and/or face swelling, fissured tongue, and intermittent facial palsy. ",
"The patient has a typical for Melkersson-Rosenthal syndrome triad of symptoms: bilateral facial nerve palsy, lingua plicata and facial oedema. ",
"Melkersson-Rosentha... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16856704",
"http://www.ncbi.nlm.nih.gov/pubmed/1597367",
"http://www.ncbi.nlm.nih.gov/pubmed/15865255",
"http://www.ncbi.nlm.nih.gov/pubmed/16989500",
"http://www.ncbi.nlm.nih.gov/pubmed/10481507",
"http://www.ncbi.nlm.nih.gov/pubmed/11995671",
"http://www.ncbi.nlm.ni... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008556",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"http://www.disease-ontology.org/api/metadata/DOID:1761",
"http://www.disease-ontology.org/api/metadata/DOID:225"
] |
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