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medium_convergence_00204 | Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.245 and an adjusted p-value of 0.008148. Which protein is encoded by this gene? | Transmembrane protein 200A | Medium | convergence | {"qa_id":"medium_convergence_00204","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific gene. Experimental data for this gene in macrophages (from ... | |
medium_convergence_00206 | ATM and RUVBL1 share a common interacting partner. Evidence regarding this partner states: 'We confirmed that this partner binds to Tel2 also in mammalian cells, and this partner interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP).' Which disease is ... | neurodevelopmental disorder with microcephaly and movement abnormalities | Medium | convergence | {"qa_id":"medium_convergence_00206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and RUVBL1 share a common interacting partner. Evidence regarding this partner states: 'We confirmed that this partner binds to Tel2 also in mammalian ce... | |
medium_convergence_00207 | Both Human polyomavirus 1 and Human immunodeficiency virus 1 are known to upregulate a specific gene. Experimental data for this gene, derived from renal epithelial cells in study GSE135833, reports a log2 fold change of approximately 1.29 and an adjusted p-value of approximately 0.019. Which disease is associated with... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_00207","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Human immunodeficiency virus 1 are known to upregulate a specific gene. Experimental data for this gene, derived from renal epi... | |
medium_convergence_00208 | BEX3 and BDNF both interact with a specific protein. Evidence indicates that this protein forms a complex with proBDNF (a precursor of brain-derived neurotrophic factor) and Huntingtin associated protein-1 (HAP1), playing a crucial role in the intracellular trafficking and stabilization of proBDNF. Which protein is enc... | Sortilin | Medium | convergence | {"qa_id":"medium_convergence_00208","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BEX3 and BDNF both interact with a specific protein. Evidence indicates that this protein forms a complex with proBDNF (a precursor of brain-derived neurotro... | |
medium_convergence_00209 | ASF1A and ASF1B both interact with a common protein partner. Experimental evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCAF-1. Which protein is encoded by the gene corresponding to this shared interaction partner? | Chromatin assembly factor 1 subunit B | Medium | convergence | {"qa_id":"medium_convergence_00209","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASF1A and ASF1B both interact with a common protein partner. Experimental evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hC... | |
medium_convergence_00210 | BRD4 and RELA both interact with a shared protein. Evidence indicates that this shared protein binds directly to the largest subunit, RFC-140, thereby interacting with the entire RFC complex. Which protein is encoded by the gene corresponding to this shared entity? | Replication factor C subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_00210","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and RELA both interact with a shared protein. Evidence indicates that this shared protein binds directly to the largest subunit, RFC-140, thereby intera... | |
medium_convergence_00211 | DIS3 and EXOSC7 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein is encoded by this shared partner? | Exosome complex component RRP43 | Medium | convergence | {"qa_id":"medium_convergence_00211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC7 both interact with a shared protein partner. Evidence regarding one such partner states: 'Here, we demonstrate the association of two differe... | |
medium_convergence_00212 | HSPA8 and PSMD4 share multiple interacting partners. One such partner was identified via mass spectrometry-based interactomics as interacting with the chaperone HSC70 in neuroblastoma cells. Which protein is encoded by this specific interacting partner? | Ubiquitin carboxyl-terminal hydrolase 14 | Medium | convergence | {"qa_id":"medium_convergence_00212","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and PSMD4 share multiple interacting partners. One such partner was identified via mass spectrometry-based interactomics as interacting with the chaper... | |
medium_convergence_00213 | Vaccinia virus and Enterovirus A both downregulate a specific host gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene exhibits a log2 fold change of approximately -8.34 and an adjusted p-value of 0.0236. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00213","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific host gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicate... | |
medium_convergence_00214 | Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), this gene showed a log2 fold change of 3.731 and an adjusted p-value of 0.04933. Which protein is encoded by this gene? | Complement C1r subcomponent | Medium | convergence | {"qa_id":"medium_convergence_00214","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. In a study of non-small cell lung adenocarcin... | |
medium_convergence_00215 | CBX8 and H3C1 share multiple protein interaction partners. One such shared partner is part of a polycomb-like complex (melPRC1) identified using affinity-tagged human PCGF2, which also contains core PRC1 proteins, HPH2, and CBX8. Which protein is encoded by this shared partner? | Polycomb group RING finger protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00215","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX8 and H3C1 share multiple protein interaction partners. One such shared partner is part of a polycomb-like complex (melPRC1) identified using affinity-tag... | |
medium_convergence_00216 | GRB2 and HSPA8 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Finally, the PKAI-EGF-R association occurs through the binding of RIalpha to the SH3 domain(s) of the Grb2 adaptor protein, thus allowing the recruitment of the PKAI holoenzyme to the activated EGF-R.' W... | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_00216","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and HSPA8 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Finally, the PKAI-EGF-R association occu... | |
medium_convergence_00218 | COG2 and ARCN1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that immunoprecipitation, as well as analysis exploiting the two-hybrid system in a complete COP screen, showed physical interactions between alpha- and epsilon-COPs and between beta- and del... | Coatomer subunit beta | Medium | convergence | {"qa_id":"medium_convergence_00218","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COG2 and ARCN1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that immunoprecipitation, as... | |
medium_convergence_00219 | EAF1 and CTDP1 both interact with a shared protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecipitated from multiple cell lines using specific antibodies. Which disease is associated with this shared protein partner? | myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_00219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EAF1 and CTDP1 both interact with a shared protein partner. Experimental evidence indicates that endogenous EAF1 and this shared partner were co-immunoprecip... | |
medium_convergence_00220 | EIF3A and EIF3F share multiple binding partners. One such partner is identified in evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is encoded by the gene corresponding to this entity? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_00220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3A and EIF3F share multiple binding partners. One such partner is identified in evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 i... | |
medium_convergence_00221 | CHD4 and MBD3 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that it interacts with MBD3 both in vitro and in vivo, co-localizes with MBD3 but not with MBD2, and does not localize to methyl-CpG-rich regions in the nucleus. Which protein is encoded by the g... | Methyl-CpG-binding domain protein 3-like 2 | Medium | convergence | {"qa_id":"medium_convergence_00221","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and MBD3 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that it interacts with MBD3 both... | |
medium_convergence_00222 | ELAVL1 and AKT1 both interact with a shared protein. Evidence indicates that HuR binds to the IRES of this shared protein's transcript in vitro and in vivo, stimulating the recruitment of its mRNA into polysomes. Which protein product is encoded by this shared gene? | E3 ubiquitin-protein ligase XIAP | Medium | convergence | {"qa_id":"medium_convergence_00222","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELAVL1 and AKT1 both interact with a shared protein. Evidence indicates that HuR binds to the IRES of this shared protein's transcript in vitro and in vivo, ... | |
medium_convergence_00223 | IRF7 and MAVS each interact with more than one shared protein. Evidence concerning one shared entity reports that Cardif-mediated IFNalpha induction occurs through a direct interaction between the TRAF domain of this entity and a TRAF-interaction motif (TIM) within Cardif. Which disease is connected to this entity thro... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_00223","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRF7 and MAVS each interact with more than one shared protein. Evidence concerning one shared entity reports that Cardif-mediated IFNalpha induction occurs t... | |
medium_convergence_00224 | XRCC6 and RPA1 both interact with a specific shared protein. Experimental evidence indicates that co-immunoprecipitation analyses revealed an enhanced interaction between this shared protein and Ku70 following treatment with ionizing radiation, suggesting an association in response to DNA damage. Which protein is encod... | E3 ubiquitin-protein ligase TRIP12 | Medium | convergence | {"qa_id":"medium_convergence_00224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and RPA1 both interact with a specific shared protein. Experimental evidence indicates that co-immunoprecipitation analyses revealed an enhanced intera... | |
medium_convergence_00225 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.206 and an adjusted p-value of 0.03413. Which disease is associated with this gene through genomic alterations? | multiple sclerosis | Medium | convergence | {"qa_id":"medium_convergence_00225","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) ... | |
medium_convergence_00226 | ELOC and RNF7 each interact with more than one shared protein. Evidence concerning one shared entity states: 'Here we show that the SOCS box mediates interactions with elongins B and C, which in turn may couple SOCS proteins and their substrates to the proteasomal protein degradation pathway.' Which cellular component ... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_00226","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELOC and RNF7 each interact with more than one shared protein. Evidence concerning one shared entity states: 'Here we show that the SOCS box mediates interac... | |
medium_convergence_00227 | Fluconazole and Bexarotene both interact with a specific shared drug. Evidence regarding this shared drug includes a kinetic and dynamic interaction study involving ketoconazole, itraconazole, and the drug itself. Which disease is this shared drug indicated for? | insomnia | Medium | convergence | {"qa_id":"medium_convergence_00227","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluconazole and Bexarotene both interact with a specific shared drug. Evidence regarding this shared drug includes a kinetic and dynamic interaction study in... | |
medium_convergence_00228 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific host gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -1.87 and an adjusted p-value of 0.0025. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific host gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene... | |
medium_convergence_00229 | PCBP2 and VCP share a common interaction partner. Experimental evidence confirms that this shared partner interacts with PCBP2, AUP1, FAF2, TRIM47, ACSL3, and SQSTM1. Which protein is encoded by this shared interaction partner? | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | Medium | convergence | {"qa_id":"medium_convergence_00229","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCBP2 and VCP share a common interaction partner. Experimental evidence confirms that this shared partner interacts with PCBP2, AUP1, FAF2, TRIM47, ACSL3, an... | |
medium_convergence_00231 | Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) show a log2 fold change of approximately -1.624 and an adjusted p-value of 0.04594. Which disease is associated with this gene as a biomarker? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from s... | |
medium_convergence_00232 | PRKDC and TP53 share a common interacting partner. Evidence regarding this partner states: 'Recombinant [caspase-3] specifically cleaved p460 in the DNA-PK preparation that had been purified from Raji cells into 230- and 160-kDa polypeptides, the latter of which was detected in anti-Fas-treated Jurkat cells.' Which pro... | Caspase-3 | Medium | convergence | {"qa_id":"medium_convergence_00232","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and TP53 share a common interacting partner. Evidence regarding this partner states: 'Recombinant [caspase-3] specifically cleaved p460 in the DNA-PK p... | |
medium_convergence_00233 | COPS8 and COPS5 both interact with a specific protein complex component. Evidence indicates that Jab1/CSN5 (a subunit of the COP9 signalosome) is a proteolytic target for the ubiquitin ligase complex containing this shared component. Which protein is encoded by this shared component? | Cullin-4B | Medium | convergence | {"qa_id":"medium_convergence_00233","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS8 and COPS5 both interact with a specific protein complex component. Evidence indicates that Jab1/CSN5 (a subunit of the COP9 signalosome) is a proteolyt... | |
medium_convergence_00234 | RPS27A and DERL1 share a common interacting partner. Evidence indicates that this shared partner contains an unusual cysteine-only RING domain with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1. Which cellular component is this shared partner located in? | endoplasmic reticulum | Medium | convergence | {"qa_id":"medium_convergence_00234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPS27A and DERL1 share a common interacting partner. Evidence indicates that this shared partner contains an unusual cysteine-only RING domain with intrinsic... | |
medium_convergence_00235 | CRY1 and DCUN1D1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that a mutant form of this protein, which fails to bind CRY1, is unable to form an SCF complex. This suggests that the interaction between CRY1 and this protein is essential for the forma... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_00235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY1 and DCUN1D1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that a mutant form of th... | |
medium_convergence_00236 | NEDD4L and HSP90AA1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with Cav3 and forms a complex with the ubiquitin ligase Nedd4-2. Which protein is encoded by this shared gene? | Voltage-gated inwardly rectifying potassium channel KCNH2 | Medium | convergence | {"qa_id":"medium_convergence_00236","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and HSP90AA1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with Cav3 and forms a complex with th... | |
medium_convergence_00237 | ADRM1 and PSMA4 share a common binding partner. Evidence regarding this shared entity states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which disease is associated with this shared entity? | plasma cell myeloma | Medium | convergence | {"qa_id":"medium_convergence_00237","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMA4 share a common binding partner. Evidence regarding this shared entity states: 'In the present study, we demonstrate that the 20S proteasome s... | |
medium_convergence_00238 | MYO6 and PRKN share a common interacting partner. Experimental evidence indicates that the MVI cargo domain binds to the C-terminal M2 and DHR2 domains of this shared partner via its RRL motif, and this interaction has been observed in multiple cell lines. Which disease is associated with this shared partner through ge... | hyperlipidemia | Medium | convergence | {"qa_id":"medium_convergence_00238","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYO6 and PRKN share a common interacting partner. Experimental evidence indicates that the MVI cargo domain binds to the C-terminal M2 and DHR2 domains of th... | |
medium_convergence_00239 | LRRK2 and CSNK1D both interact with a specific protein within the dishevelled family (DVL1-3). Evidence regarding this shared interaction partner states: 'We report the interaction of LRRK2 with the dishevelled family of phosphoproteins (DVL1-3), key regulators of Wnt (Wingless/Int) signalling pathways important for ax... | Segment polarity protein dishevelled homolog DVL-2 | Medium | convergence | {"qa_id":"medium_convergence_00239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRRK2 and CSNK1D both interact with a specific protein within the dishevelled family (DVL1-3). Evidence regarding this shared interaction partner states: 'We... | |
medium_convergence_00240 | CEBPA and JUN both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we show that MBF1 and the related Chameau and HBO1 histone acetylases interact with distinct subgroups of bZIP proteins, whereas pX does not discriminate.' Which protein is encoded by this shared entity? | Endothelial differentiation-related factor 1 | Medium | convergence | {"qa_id":"medium_convergence_00240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and JUN both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we show that MBF1 and the related Chameau and HBO1 hi... | |
medium_convergence_00241 | NR3C1 and NFIA share a common interaction partner. Evidence regarding this shared partner states: 'Mechanistically, co-immunoprecipitation assays revealed that the protein encoded by the shared partner gene is associated with GR in a ligand-independent manner in APRE-19 cells.' Which protein is encoded by the gene corr... | Histone-lysine N-methyltransferase 2D | Medium | convergence | {"qa_id":"medium_convergence_00241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and NFIA share a common interaction partner. Evidence regarding this shared partner states: 'Mechanistically, co-immunoprecipitation assays revealed th... | |
medium_convergence_00242 | SMAD3 and SMAD7 both interact with a shared protein. Evidence regarding this shared protein indicates that Co-immunoprecipitation studies suggest an interaction between a specific protein and either CA-Smad3 or wild-type Smad3 in HEK293 cells. This interaction occurs through the MH2 domain of Smad3 and the C terminus o... | basophil | Medium | convergence | {"qa_id":"medium_convergence_00242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and SMAD7 both interact with a shared protein. Evidence regarding this shared protein indicates that Co-immunoprecipitation studies suggest an interact... | |
medium_convergence_00243 | BIRC2 and BIRC3 both interact with a specific protein. Evidence indicates that a specific kinase interacts with the second baculovirus IAP repeat (BIR2) domain of c-IAP1 via the IBM, and this interaction provides substrate recognition for c-IAP1-mediated ubiquitylation and degradation of this kinase. Which protein, enc... | Mitogen-activated protein kinase kinase kinase 14 | Medium | convergence | {"qa_id":"medium_convergence_00243","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a specific protein. Evidence indicates that a specific kinase interacts with the second baculovirus IAP repeat (BIR2) doma... | |
medium_convergence_00244 | DUSP1 and ABL1 both interact with a specific MAP kinase isoform. Evidence indicates that MKP-1 (encoded by DUSP1) interacts selectively with ERK1/2, a specific p38 isoform, and JNK. Which protein is encoded by the gene corresponding to the p38 isoform mentioned in this context? | Mitogen-activated protein kinase 14 | Medium | convergence | {"qa_id":"medium_convergence_00244","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DUSP1 and ABL1 both interact with a specific MAP kinase isoform. Evidence indicates that MKP-1 (encoded by DUSP1) interacts selectively with ERK1/2, a specif... | |
medium_convergence_00245 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -2.591 and an adjusted p-value of 0.02331. Which protein is encoded by this gene? | Forkhead box protein O3 | Medium | convergence | {"qa_id":"medium_convergence_00245","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) s... | |
medium_convergence_00246 | CUL4B and CUL4A each interact with more than one shared partner. Evidence concerning one shared entity reports that it binds to UV-damaged chromatin as a part of the DDB1-containing E3 ligase complex in the presence of functional copies of this protein. Which cell type is connected to that entity through the 'enriched ... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_00246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL4B and CUL4A each interact with more than one shared partner. Evidence concerning one shared entity reports that it binds to UV-damaged chromatin as a par... | |
medium_convergence_00247 | The uriniferous tubule and the primitive nephron share a common anatomical classification. Evidence regarding this shared entity describes it as the 'Functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule.' What is the broader anatomical category to which this sha... | tube | Medium | convergence | {"qa_id":"medium_convergence_00247","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The uriniferous tubule and the primitive nephron share a common anatomical classification. Evidence regarding this shared entity describes it as the 'Functio... | |
medium_convergence_00248 | CDK4 and AKAP13 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Both Ht 31 (493-515) peptide and its parent protein bind RII alpha or the type II PKA holoenzyme with high affinity.' Which protein is encoded by the gene corresponding to this shared interaction partner? | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_00248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK4 and AKAP13 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Both Ht 31 (493-515) peptide and its paren... | |
medium_convergence_00249 | Both Human alphaherpesvirus 1 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene, derived from a monocytic leukemia cell line (study GSE114966), reports a log2 fold change of approximately 1.128 and an adjusted p-value of 0.008292. In which cellular component is the protein... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene, derived from a monocytic leuk... | |
medium_convergence_00250 | PPP2CB and PPP2R1A both interact with a specific shared protein. Evidence indicates that PP2A associates with separase through the B' (B56) regulatory subunit, a process independent of securin and cyclin B1 binding. Which protein is encoded by this shared interaction partner? | Separin | Medium | convergence | {"qa_id":"medium_convergence_00250","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CB and PPP2R1A both interact with a specific shared protein. Evidence indicates that PP2A associates with separase through the B' (B56) regulatory subuni... | |
medium_convergence_00251 | HCFC1 and KANSL3 both interact with a specific protein. Evidence regarding this protein states: 'We also find that [the protein] is a component of additional complexes, forming associations with host cell factor 1 and a protein distantly related to MSL1 (hMSL1v1).' Which protein is encoded by the gene corresponding to ... | Histone acetyltransferase KAT8 | Medium | convergence | {"qa_id":"medium_convergence_00251","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HCFC1 and KANSL3 both interact with a specific protein. Evidence regarding this protein states: 'We also find that [the protein] is a component of additional... | |
medium_convergence_00252 | Measles morbillivirus and Human orthopneumovirus both upregulate a shared gene. Evidence for this shared target reports a log2 fold change of 1.161 and an adjusted p-value of 0.04609. Which protein is encoded by this gene? | Basic helix-loop-helix ARNT-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00252","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Human orthopneumovirus both upregulate a shared gene. Evidence for this shared target reports a log2 fold change of 1.161 and an ad... | |
medium_convergence_00253 | DLG3 and CAMK2B both interact with a specific shared protein partner. Evidence regarding this partner states: 'We quantitatively defined the contributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 (PSD-95) and its homolog sy... | Glutamate receptor ionotropic, NMDA 2B | Medium | convergence | {"qa_id":"medium_convergence_00253","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and CAMK2B both interact with a specific shared protein partner. Evidence regarding this partner states: 'We quantitatively defined the contributions of... | |
medium_convergence_00254 | MCM8 and CDC6 both interact with a specific protein. Experimental evidence indicates that this protein binds strongly to ORC1 and MCM7. Which protein product is encoded by this interacting partner? | Origin recognition complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_00254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM8 and CDC6 both interact with a specific protein. Experimental evidence indicates that this protein binds strongly to ORC1 and MCM7. Which protein product... | |
medium_convergence_00255 | SEC61B and GGA3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Crystallographic analyses demonstrate that the phosphoserine residue interacts electrostatically with two basic residues on the VHS domain of GGA3, thus providing an additional point of attachment of the acidic... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC61B and GGA3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Crystallographic analyses demonstrate that the ... | |
medium_convergence_00256 | TRAF3IP2 and MAP3K5 both interact with a shared protein. Evidence indicates that this shared protein, along with TRAF2 and TRAF6, associates with apoptosis signal-regulating kinase 1 (ASK1), and that a catalytically inactive ASK1 mutant blocks stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) activat... | TNF receptor-associated factor 5 | Medium | convergence | {"qa_id":"medium_convergence_00256","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF3IP2 and MAP3K5 both interact with a shared protein. Evidence indicates that this shared protein, along with TRAF2 and TRAF6, associates with apoptosis s... | |
medium_convergence_00257 | Both inner root sheath cells and outer root sheath cells are subtypes of a common parent cell type. Evidence indicates that an epithelial cell residing in the inner root sheath of the hair follicle is an instance of this parent type. What is the broader cell category that this parent type belongs to? | general ecto-epithelial cell | Medium | convergence | {"qa_id":"medium_convergence_00257","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both inner root sheath cells and outer root sheath cells are subtypes of a common parent cell type. Evidence indicates that an epithelial cell residing in th... | |
medium_convergence_00258 | TRIM28 and FOXK2 both interact with a shared protein. Evidence for the interaction involving this shared protein and TRIM28 was confirmed by co-immunoprecipitation and immunocytochemistry. Which protein is encoded by this shared entity? | RE1-silencing transcription factor | Medium | convergence | {"qa_id":"medium_convergence_00258","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and FOXK2 both interact with a shared protein. Evidence for the interaction involving this shared protein and TRIM28 was confirmed by co-immunoprecipi... | |
medium_convergence_00259 | HDAC1 and FOXK2 share common interaction partners. One such shared partner is described as a protein that inhibits histone acetylation in vitro and in vivo and binds the histone deacetylase HDAC1. Which protein is encoded by this specific shared partner? | Inhibitor of growth protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and FOXK2 share common interaction partners. One such shared partner is described as a protein that inhibits histone acetylation in vitro and in vivo a... | |
medium_convergence_00260 | H2AX and HIST3H3 each interact with more than one shared protein. Evidence concerning one shared entity reports that this protein forms complexes with phosphorylated H2AX. Which disease is connected to that entity through a biomarker relationship? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and HIST3H3 each interact with more than one shared protein. Evidence concerning one shared entity reports that this protein forms complexes with phosph... | |
medium_convergence_00261 | C9orf72 and FBXO7 share multiple interacting partners. One such shared partner is identified in experimental evidence as a direct interactor of FBXO7, specifically described as a subunit. Which disease is associated with this specific shared partner? | congenital disorder of glycosylation, type IIy | Medium | convergence | {"qa_id":"medium_convergence_00261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C9orf72 and FBXO7 share multiple interacting partners. One such shared partner is identified in experimental evidence as a direct interactor of FBXO7, specif... | |
medium_convergence_00262 | RBBP5 and CBFB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We report the 2.6 A resolution crystal structure of the complex between the [RUNX1] Runt domain and CBFbeta, which represents a paradigm for the mode of interaction of this highly conserved famil... | Runt-related transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_00262","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBBP5 and CBFB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We report the 2.6 A resolution c... | |
medium_convergence_00263 | Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of -2.019 and an adjusted p-value of 0.002316. Which biological process is this gene involved in? | positive regulation of focal adhesion assembly | Medium | convergence | {"qa_id":"medium_convergence_00263","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) show... | |
medium_convergence_00264 | TXNIP and PARP1 share multiple interacting partners. One such partner is described in a study stating: 'In this study, we discovered that ubiquitin-specific protease 5 interacts with TXNIP and stabilizes it through deubiquitylation in Huh-7 and HepG2 cells after treatment with lipopolysaccharide.' Which protein is enco... | Ubiquitin carboxyl-terminal hydrolase 5 | Medium | convergence | {"qa_id":"medium_convergence_00264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TXNIP and PARP1 share multiple interacting partners. One such partner is described in a study stating: 'In this study, we discovered that ubiquitin-specific ... | |
medium_convergence_00265 | CRK and BIN1 share common interaction partners. One such partner is identified in experimental evidence stating: 'Co-immunoprecipitation of whole cell extracts demonstrated that the guanylnucleotide exchange factor SOS was associated with the small adapter proteins Grb2, CrkII, and Nck.' Which disease is connected to t... | colitis | Medium | convergence | {"qa_id":"medium_convergence_00265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and BIN1 share common interaction partners. One such partner is identified in experimental evidence stating: 'Co-immunoprecipitation of whole cell extrac... | |
medium_convergence_00266 | FYN and GRB2 both interact with a specific receptor tyrosine kinase. Evidence indicates that Tyr-716, a novel autophosphorylation site in the kinase insert of the PDGF beta-receptor, mediates the direct binding of GRB2 in vitro and in vivo. Which protein is encoded by the gene corresponding to this receptor? | Platelet-derived growth factor receptor beta | Medium | convergence | {"qa_id":"medium_convergence_00266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and GRB2 both interact with a specific receptor tyrosine kinase. Evidence indicates that Tyr-716, a novel autophosphorylation site in the kinase insert o... | |
medium_convergence_00267 | AMFR and TP53 share multiple interacting partners. One such partner is characterized by evidence stating that its association with p53 requires an intact C-terminal domain of p53 and is markedly stronger with a p53 mutant that cannot tetramerize. Which protein is encoded by the gene corresponding to this interacting pa... | Ubiquitin-conjugating enzyme E2 N | Medium | convergence | {"qa_id":"medium_convergence_00267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMFR and TP53 share multiple interacting partners. One such partner is characterized by evidence stating that its association with p53 requires an intact C-t... | |
medium_convergence_00268 | CDK2 and CDKN1C share a common interaction partner. Evidence indicates that this shared entity forms complexes with Cyclin A and Cyclin E, which phosphorylate a transcription factor in a cell-free system at the same sites as in intact cells. Which biological process is this shared entity involved in? | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_00268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CDKN1C share a common interaction partner. Evidence indicates that this shared entity forms complexes with Cyclin A and Cyclin E, which phosphorylat... | |
medium_convergence_00269 | HDAC1 and NFIX share common interaction partners. One such shared partner is characterized by evidence indicating it preferably interacts with HDAC1 and mSin3A. Which biological process is this specific shared partner involved in? | immune response | Medium | convergence | {"qa_id":"medium_convergence_00269","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and NFIX share common interaction partners. One such shared partner is characterized by evidence indicating it preferably interacts with HDAC1 and mSin... | |
medium_convergence_00270 | Measles morbillivirus and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of approximately 3.28 and an adjusted p-value of approximately 0.0031. In which cell type is this gene enriched? | basophil | Medium | convergence | {"qa_id":"medium_convergence_00270","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of app... | |
medium_convergence_00271 | CHEK2 and UHRF1 share a common interaction partner. Evidence indicates that this shared partner is an MMR protein that interacts with both Chk1 and Chk2, an interaction enhanced after MNNG exposure, supporting the notion that the MMR system functions as a molecular scaffold at DNA damage sites. Which protein is encoded... | DNA mismatch repair protein Msh2 | Medium | convergence | {"qa_id":"medium_convergence_00271","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and UHRF1 share a common interaction partner. Evidence indicates that this shared partner is an MMR protein that interacts with both Chk1 and Chk2, an ... | |
medium_convergence_00272 | CAND1 and CUL3 each interact with multiple shared partners. Evidence concerning one such partner states: 'To define the molecular basis for this assembly and the overall architecture of the E3, we determined the crystal structures of the BTB-BACK domains of this protein both alone and in complex with Cul3, along with t... | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | convergence | {"qa_id":"medium_convergence_00272","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL3 each interact with multiple shared partners. Evidence concerning one such partner states: 'To define the molecular basis for this assembly and... | |
medium_convergence_00273 | AP4E1 and HOOK1 both interact with a common protein partner. Experimental evidence regarding this shared partner indicates that FTS is associated with a conserved C-terminal motif in Hook proteins, as observed in yeast two-hybrid systems and tissue culture cells, and that Hook proteins form homo- and heterodimers. Whic... | FHF complex subunit HOOK-interacting protein 1B | Medium | convergence | {"qa_id":"medium_convergence_00273","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP4E1 and HOOK1 both interact with a common protein partner. Experimental evidence regarding this shared partner indicates that FTS is associated with a cons... | |
medium_convergence_00274 | Hepacivirus C and Dengue virus both downregulate a specific gene. Evidence for this gene reports a log2 fold change of -1.212 and an adjusted p-value of 6.691e-05. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_00274","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Evidence for this gene reports a log2 fold change of -1.212 and an adjusted p-value of 6.69... | |
medium_convergence_00275 | KIAA1549 and KSR1 share common binding partners. One such shared partner is described in evidence stating that C-TAK1 constitutively associates with mammalian KSR1 and phosphorylates serine 392 to confer 14-3-3 binding and cytoplasmic sequestration of KSR1 in unstimulated cells. Which protein is encoded by the gene cor... | MAP/microtubule affinity-regulating kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_00275","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KIAA1549 and KSR1 share common binding partners. One such shared partner is described in evidence stating that C-TAK1 constitutively associates with mammalia... | |
medium_convergence_00276 | CTNNB1 and EGFR share a common interacting partner. Evidence indicates that this shared partner stabilizes CTNNB1 by suppressing its degradation. Which protein is encoded by the gene corresponding to this shared partner? | Ubiquitin carboxyl-terminal hydrolase 33 | Medium | convergence | {"qa_id":"medium_convergence_00276","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and EGFR share a common interacting partner. Evidence indicates that this shared partner stabilizes CTNNB1 by suppressing its degradation. Which prote... | |
medium_convergence_00277 | UBXN2A and NSFL1C both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named [REDACTED] (valosin-containing protein [VCP][p97]/p47 complex-interacting protein, p135), and show that it bind... | Deubiquitinating protein VCPIP1 | Medium | convergence | {"qa_id":"medium_convergence_00277","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBXN2A and NSFL1C both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Now we have identified a novel essential... | |
medium_convergence_00278 | DLG4 and SLC1A2 both interact with a specific kainate receptor subunit. Evidence indicates that PDZ domain-containing proteins, including syntenin, PICK1, GRIP, and PSD95, interact with kainate receptor (KAR) subunits GluR5(2b), GluR5(2c), and a specific subunit. Which disease is associated with this specific subunit t... | autosomal recessive juvenile Parkinson disease 2 | Medium | convergence | {"qa_id":"medium_convergence_00278","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and SLC1A2 both interact with a specific kainate receptor subunit. Evidence indicates that PDZ domain-containing proteins, including syntenin, PICK1, GR... | |
medium_convergence_00279 | SMG1 and ATM both interact with a shared protein. Experimental evidence indicates that this shared protein binds to the HEAT repeat segments of ATM and mTOR. Which protein is encoded by the gene corresponding to this shared entity? | Telomere length regulation protein TEL2 homolog | Medium | convergence | {"qa_id":"medium_convergence_00279","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and ATM both interact with a shared protein. Experimental evidence indicates that this shared protein binds to the HEAT repeat segments of ATM and mTOR.... | |
medium_convergence_00280 | SIRT1 and MYC both interact with a shared protein entity. Evidence indicates that this specific entity associates directly with FoxO proteins and regulators, functions as a class III histone deacetylase (HDAC) known as sirtuin 1, and interacts with protein phosphatase 1. Which protein is connected to this entity throug... | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_00280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and MYC both interact with a shared protein entity. Evidence indicates that this specific entity associates directly with FoxO proteins and regulators,... | |
medium_convergence_00281 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line study (GSE11238) indicates that for one such shared target, the log2 fold change is -2.387 and the adjusted p-value is 0.003177. Which disease is associated with this specific gene th... | Cold-induced sweating syndrome 1 | Medium | convergence | {"qa_id":"medium_convergence_00281","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line study (GSE11238) ind... | |
medium_convergence_00282 | ERBB2 and PRKN share interaction partners. One such partner is described in evidence stating: 'We have identified ERBIN and this protein as new binding partners for ERBB2/HER2 that associate with its carboxyl-terminal sequence through a PDZ (PSD-95/DLG/ZO-1) domain.' Which protein is encoded by this shared interaction ... | PRKCA-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00282","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and PRKN share interaction partners. One such partner is described in evidence stating: 'We have identified ERBIN and this protein as new binding partn... | |
medium_convergence_00283 | Both Measles morbillivirus and Dengue virus have been shown to upregulate the expression of a specific gene. In a study involving pleural mesothelioma cells (GSE117668), evidence for one such shared target reports a log2 fold change of 3.251 and an adjusted p-value of 0.001084. Which protein is encoded by this gene? | DNA primase small subunit | Medium | convergence | {"qa_id":"medium_convergence_00283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus have been shown to upregulate the expression of a specific gene. In a study involving pleural mesothelioma cells ... | |
medium_convergence_00284 | VPS18 and VPS33A both interact with a specific protein that functions as a Beclin1-binding autophagic tumor suppressor and interacts with the class C Vps complex, a key component of the endosomal fusion machinery. Which protein is encoded by this gene? | UV radiation resistance-associated gene protein | Medium | convergence | {"qa_id":"medium_convergence_00284","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS18 and VPS33A both interact with a specific protein that functions as a Beclin1-binding autophagic tumor suppressor and interacts with the class C Vps com... | |
medium_convergence_00285 | CREBBP and BMAL1 both interact with a specific shared protein. Evidence indicates that this protein (or its paralog) engages in light-independent interactions with CLOCK, BMAL1, PER1, PER2, and TIM. Which protein is encoded by the gene corresponding to this shared entity? | Cryptochrome-1 | Medium | convergence | {"qa_id":"medium_convergence_00285","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and BMAL1 both interact with a specific shared protein. Evidence indicates that this protein (or its paralog) engages in light-independent interaction... | |
medium_convergence_00286 | EXOSC8 and YWHAB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In this study, we show that the protein encoded by ZFP36 and the related proteins TIS11b and TIS11d bind specifically to 14-3-3 proteins and that individual 14-3-3 isoforms preferentially bind ... | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_00286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC8 and YWHAB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In this study, we show that th... | |
medium_convergence_00287 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 2.05 and an adjusted p-value of 0.001099. Which disease is associated with this gene as a biomarker? | leprosy | Medium | convergence | {"qa_id":"medium_convergence_00287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_00289 | CREBBP and CTNNB1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that phosphorylation of this entity induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein. Which disease is connected to that entity through... | primary effusion lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00289","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and CTNNB1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that phosphorylation of this entity ind... | |
medium_convergence_00290 | Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.807 and an adjusted p-value of 0.03331. Which protein is encoded by this gene? | ATP synthase F(0) complex subunit a | Medium | convergence | {"qa_id":"medium_convergence_00290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports... | |
medium_convergence_00291 | NEDD4L and NEDD4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'To bring insights into the biochemical function of human [LITAF], we confirmed that human [LITAF] interacts with NEDD4 and also report a novel interaction with tumor susceptibility gene 101 (TSG101), a class E ... | Lipopolysaccharide-induced tumor necrosis factor-alpha factor | Medium | convergence | {"qa_id":"medium_convergence_00291","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and NEDD4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'To bring insights into the biochemical function... | |
medium_convergence_00292 | Both CRYAA and CRYAB interact with a specific shared protein. Experimental evidence involving Chloramphenicol acetyltransferase activity indicates that this shared protein interacts with alphaA- or alphaB-crystallins with an intensity one-third that of alphaA-alphaB interactions. Which disease is associated with this s... | cataract 3 multiple types | Medium | convergence | {"qa_id":"medium_convergence_00292","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CRYAA and CRYAB interact with a specific shared protein. Experimental evidence involving Chloramphenicol acetyltransferase activity indicates that this ... | |
medium_convergence_00293 | RANBP9 and COPS5 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Co-immunoprecipitation studies in HEK293 cells indicated that RanBPM constitutively associates with the mu-opioid receptor.' Which protein is encoded by this shared entity? | Mu-type opioid receptor | Medium | convergence | {"qa_id":"medium_convergence_00293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and COPS5 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Co-immunoprecipitation studies in HEK293 cells ... | |
medium_convergence_00294 | AKT1 and GIGYF2 share multiple interaction partners. One such shared partner is supported by evidence stating: 'We provide evidence that Akt directly binds this protein and is able to phosphorylate it in an in vitro kinase assay.' Which protein is connected to that entity through the 'encodes' relationship? | Growth factor receptor-bound protein 10 | Medium | convergence | {"qa_id":"medium_convergence_00294","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and GIGYF2 share multiple interaction partners. One such shared partner is supported by evidence stating: 'We provide evidence that Akt directly binds t... | |
medium_convergence_00295 | GRIN1 and GRIN2A each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Coimmunoprecipitation analysis showed that NR3B could form NMDA receptor complex with NR1a and NR2A subunits in heterologous cells.' Which protein is encoded by the gene corresponding to that s... | Glutamate receptor ionotropic, NMDA 3B | Medium | convergence | {"qa_id":"medium_convergence_00295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIN1 and GRIN2A each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Coimmunoprecipitation analysis... | |
medium_convergence_00296 | Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) show a log2 fold change of approximately -1.35 and an adjusted p-value of 0.0007046. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD12 | Medium | convergence | {"qa_id":"medium_convergence_00296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesoth... | |
medium_convergence_00297 | PCM1 and UBR5 share common interacting partners. One such partner is described in experimental evidence as a centrosomal and ciliary protein required for cilia formation, identified as an interacting protein of UBR5 following validation of depletion effects on primary cilia formation. Which cell type is this specific s... | basophil | Medium | convergence | {"qa_id":"medium_convergence_00297","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCM1 and UBR5 share common interacting partners. One such partner is described in experimental evidence as a centrosomal and ciliary protein required for cil... | |
medium_convergence_00298 | NCOR1 and NCOR2 both interact with a specific nuclear receptor. Experimental evidence from mammalian two-hybrid assays indicates that the interaction of VP16-SMRT or VP16-NCoR is stronger with Gal4-TR than with Gal4-[this receptor]. Which disease is genetically associated with this receptor? | osteoarthritis, hip | Medium | convergence | {"qa_id":"medium_convergence_00298","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOR1 and NCOR2 both interact with a specific nuclear receptor. Experimental evidence from mammalian two-hybrid assays indicates that the interaction of VP16... | |
medium_convergence_00299 | Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Evidence for this gene's expression change in a particular study reports a log2 fold change of approximately -1.32 and an adjusted p-value of approximately 0.047. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_00299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Evidence for this gene's expression change in a... | |
medium_convergence_00300 | EIF3K and EIF3E share a common binding partner. Evidence regarding this shared partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which cellular component is this shared partner located in? | eukaryotic translation initiation factor 3 complex | Medium | convergence | {"qa_id":"medium_convergence_00300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3K and EIF3E share a common binding partner. Evidence regarding this shared partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs... | |
medium_convergence_00301 | PPP1R15A and HSPA8 both interact with a shared protein. Evidence indicates that this shared protein, identified as the human cochaperone BAG-1, interacts with GADD34 in vitro and in SW480 cells treated with the proteasome inhibitor z-LLL-B to induce apoptosis. Which cell type is this shared protein enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_00301","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP1R15A and HSPA8 both interact with a shared protein. Evidence indicates that this shared protein, identified as the human cochaperone BAG-1, interacts wit... | |
medium_convergence_00302 | The intervertebral disk of the lumbar vertebra and the lumbar vertebra endochondral element are both classified as types of a specific anatomical category. Evidence regarding this category states: 'An intervertebral disk that is part of a lumbar region of vertebral column. A lumbar intervertebral disk connects at least... | dorsum | Medium | convergence | {"qa_id":"medium_convergence_00302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The intervertebral disk of the lumbar vertebra and the lumbar vertebra endochondral element are both classified as types of a specific anatomical category. E... | |
medium_convergence_00303 | CDC37 and HSP90AA1 both interact with a specific shared gene product. Contextual evidence indicates that this shared entity interacts with HSP90-1beta, HSC70, and HSP70 proteins, an association required for its kinase activity. Which gene does this shared entity interact with? | CCT6A | Medium | convergence | {"qa_id":"medium_convergence_00303","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and HSP90AA1 both interact with a specific shared gene product. Contextual evidence indicates that this shared entity interacts with HSP90-1beta, HSC70... | |
medium_convergence_00304 | CENPA and B9D2 share multiple protein interaction partners. One such shared partner is mentioned in the following evidence: 'Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and CENP-T), along wi... | Centromere protein N | Medium | convergence | {"qa_id":"medium_convergence_00304","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and B9D2 share multiple protein interaction partners. One such shared partner is mentioned in the following evidence: 'Here, we show that CENP-A nucleo... | |
medium_convergence_00305 | STUB1 and DNAJB4 both interact with a shared protein. Evidence indicates that this shared protein, BAG-1, directly interacts with CHIP, accepts substrates from Hsc/Hsp70, and presents associated proteins to the CHIP ubiquitin conjugation machinery. Which protein is encoded by this shared entity? | BAG family molecular chaperone regulator 1 | Medium | convergence | {"qa_id":"medium_convergence_00305","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and DNAJB4 both interact with a shared protein. Evidence indicates that this shared protein, BAG-1, directly interacts with CHIP, accepts substrates fr... | |
medium_convergence_00306 | DYNC1H1 and DYNC1LI2 both interact with a shared protein. Evidence indicates that overexpression of the N-terminal domain of this shared protein disrupts minus-end-directed organelle distribution, and this domain co-precipitates with cytoplasmic dynein. Which protein is encoded by the gene corresponding to this shared ... | Protein bicaudal D homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_00306","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYNC1H1 and DYNC1LI2 both interact with a shared protein. Evidence indicates that overexpression of the N-terminal domain of this shared protein disrupts min... | |
medium_convergence_00307 | Both Human betaherpesvirus 5 and Human mastadenovirus C are known to upregulate a specific gene. In a study of retinal pigment epithelium cells (GSE120891), the upregulation of this gene was associated with a log2 fold change of approximately 1.299 and an adjusted p-value of 0.001977. Which protein is encoded by this g... | Serine/threonine-protein kinase pim-3 | Medium | convergence | {"qa_id":"medium_convergence_00307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Human mastadenovirus C are known to upregulate a specific gene. In a study of retinal pigment epithelium cells (GSE120891), ... |
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