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medium_convergence_00101 | BATF2 and BTRC have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes an E3 ligase component interacting with a specific signaling mediator but not with related family members. Which disease has a causal association with... | cleidocranial dysplasia 1 | Medium | convergence | {"qa_id":"medium_convergence_00101","source_qa_id":"medium_convergence_two_branch_unequal_context_0771","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BATF2 and BTRC have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00102 | LRP10 and ERBB2IP have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes how a scaffold protein containing specific domains interacts specifically with signaling molecules through a novel adjacent domain. Which disease i... | cervical carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00102","source_qa_id":"medium_convergence_two_branch_unequal_context_0272","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"LRP10 and ERBB2IP have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00103 | TRIO and ECT2 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the interaction between a guanine nucleotide exchange factor domain and an actin-crosslinking protein along with their cellular colocalization. For which disease is this protein reported as a biomarker... | FG syndrome | Medium | convergence | {"qa_id":"medium_convergence_00103","source_qa_id":"medium_convergence_two_branch_equal_context_0938","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"TRIO and ECT2 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00104 | CDH16 and ZBTB33 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes how a transcriptional repressor suppresses a complex by associating with both a T cell factor and a signaling scaffold protein. Which disease has a ... | proteinuria | Medium | convergence | {"qa_id":"medium_convergence_00104","source_qa_id":"medium_convergence_two_branch_unequal_context_0170","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"CDH16 and ZBTB33 have overlapping extended protein-interaction neighborhoods containing se... | |
medium_convergence_00105 | IL1RN and PRAME have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes direct interaction with Elongin C and Golgi colocalization after PAMP and IFN gamma treatment. Which disease is associated with this protein? | renal cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00105","source_qa_id":"medium_convergence_two_branch_unequal_context_0463","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"IL1RN and PRAME have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00106 | CDH16 and HSPB8 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes HSP22 interacting with itself, cvHSP, MKBP, and a small heat shock protein detected by yeast two-hybrid and FRET microscopy. Which disease is linked ... | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00106","source_qa_id":"medium_convergence_two_branch_unequal_context_0154","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"CDH16 and HSPB8 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00107 | West Nile virus and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a foreskin fibroblast cell line with a log2 fold-change of about 1.67 and an adjusted p-value of about 0.038. For which disease is this gene reported as a b... | asthma | Medium | convergence | {"qa_id":"medium_convergence_00107","source_qa_id":"medium_convergence_two_branch_equal_context_1135","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human alphaherpesvirus 1 alter the expression of several genes in common. ... | |
medium_convergence_00108 | TCF24 and SATB1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the identification of several proteins including a small ubiquitin-like modifier and its conjugating enzyme as interaction partners of a chromatin or... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_00108","source_qa_id":"medium_convergence_two_branch_unequal_context_0039","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"TCF24 and SATB1 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00110 | HSPE1, AURKB, and NR3C1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the identification of pyruvate dehydrogenase and a heat shock protein as potent binding partners for mitochondrial glucocorticoid receptor. Which disease has a therapeutic association with th... | cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00110","source_qa_id":"medium_convergence_three_branch_context_0598","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"HSPE1, AURKB, and NR3C1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00111 | IL12RB2 and CBL have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the formation of a signaling complex that translocates to lipid rafts in growth cones after stimulation. Which disease has a causal association with ... | cone dystrophy | Medium | convergence | {"qa_id":"medium_convergence_00111","source_qa_id":"medium_convergence_two_branch_unequal_context_0474","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"IL12RB2 and CBL have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00112 | MME, EGFR, and ANLN share more than one reported protein partner. Evidence concerning one of these shared proteins describes the identification of a fifty-six kiloDalton phosphoprotein associated with a membrane metalloendopeptidase as a src-related kinase via immunoprecipitation. Which disease is linked to genomic alt... | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00112","source_qa_id":"medium_convergence_three_branch_context_0428","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"MME, EGFR, and ANLN share more than one reported protein partner. Evidence concerning one of these sha... | |
medium_convergence_00113 | RAP1GAP and KRAS share more than one reported protein partner. Evidence concerning one of these shared proteins describes in vivo interaction between a polo-like kinase and a GTPase activating protein mediated by recognition of a specific motif. Which disease is linked to genomic alterations in this protein's gene? | glioma | Medium | convergence | {"qa_id":"medium_convergence_00113","source_qa_id":"medium_convergence_two_branch_equal_context_0599","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"RAP1GAP and KRAS share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00114 | CDH16 and GSK3B have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes AICD interacting with glycogen synthase kinase 3 beta to promote its kinase activity. Which disease has a causal association with this protein? | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_00114","source_qa_id":"medium_convergence_two_branch_unequal_context_0379","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"CDH16 and GSK3B have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00115 | RAB32 and AIMP2 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes an interaction identified by interactome analysis and structurally determined by X-ray crystallography and NMR analyses. Which disease has a therapeu... | Parkinson disease | Medium | convergence | {"qa_id":"medium_convergence_00115","source_qa_id":"medium_convergence_two_branch_unequal_context_0641","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"RAB32 and AIMP2 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00116 | CAMKK1 and ZFP36 share more than one reported protein partner. Evidence concerning one of these shared proteins describes how kinase induced phosphorylation at specific serines promotes complex assembly and causes exclusion from stress granules. For which disease is this protein reported as a biomarker? | glioma | Medium | convergence | {"qa_id":"medium_convergence_00116","source_qa_id":"medium_convergence_two_branch_equal_context_0064","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CAMKK1 and ZFP36 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00117 | CRYBA2 and MUC1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a tyrosine phosphorylated protein directly interacting with the SH2 domain of an adaptor protein in human breast cancer cells. Which disease is linke... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00117","source_qa_id":"medium_convergence_two_branch_unequal_context_0865","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"CRYBA2 and MUC1 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00118 | BATF2 and ESR1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a cytoplasmic association between an E3 ligase and the N-terminal region of an estrogen receptor mediated by a specific enzymatic domain. For which di... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_00118","source_qa_id":"medium_convergence_two_branch_unequal_context_0773","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BATF2 and ESR1 have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00119 | VSIG4 and STAT3 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a physical association between a kinase and focal adhesion kinase mediated by a transcription factor. Which disease has a causal association with thi... | brain neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00119","source_qa_id":"medium_convergence_two_branch_unequal_context_0715","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"VSIG4 and STAT3 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00120 | CD22 and MUC1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a mucin c terminal subunit binding directly to a src family kinase through interactions with its sh3 and sh2 domains. Which disease is linked to genomic alterations in this protein's gene? | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00120","source_qa_id":"medium_convergence_two_branch_equal_context_0410","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CD22 and MUC1 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00121 | Human alphaherpesvirus 3 and Human respirovirus 3 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a non-small cell lung adenocarcinoma cell line with a log2 fold-change of about 1.66 and an adjusted p-value of about 0.042. Which disease is associate... | testicular cancer | Medium | convergence | {"qa_id":"medium_convergence_00121","source_qa_id":"medium_convergence_two_branch_equal_context_1178","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human alphaherpesvirus 3 and Human respirovirus 3 alter the expression of several genes in com... | |
medium_convergence_00122 | HCLS1 and HNF4A have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the interaction between a hepatocyte nuclear factor and hypoxia inducible factor subunits during low oxygen conditions. Which disease has a causal as... | cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00122","source_qa_id":"medium_convergence_two_branch_unequal_context_0403","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"HCLS1 and HNF4A have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00123 | RAB32 and FAF1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins cautiously suggests an association between a ubiquitin-like protein and a heat shock chaperone that is linked to tumor formation despite unknown molecular mecha... | Parkinson disease | Medium | convergence | {"qa_id":"medium_convergence_00123","source_qa_id":"medium_convergence_two_branch_unequal_context_0643","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"RAB32 and FAF1 have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00124 | GLP1R, DPP4, and SEC61B share more than one reported protein partner. Evidence concerning one of these shared proteins describes the validation of three novel interactors for a glucagon-like peptide one receptor using co-immunoprecipitation fluorescence resonance energy transfer and immunofluorescence. For which diseas... | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_00124","source_qa_id":"medium_convergence_three_branch_context_0507","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"GLP1R, DPP4, and SEC61B share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00125 | MRPL53 and RELA share more than one reported protein partner. Evidence concerning one of these shared proteins describes a cytokine-induced interaction between a kinase and a transcription factor subunit that depends on prior inhibitor degradation. Which disease has a causal association with this protein? | kidney cancer | Medium | convergence | {"qa_id":"medium_convergence_00125","source_qa_id":"medium_convergence_two_branch_equal_context_0155","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"MRPL53 and RELA share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00126 | MUC12 and ZFP36 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes how phosphorylation at specific serine residues promotes complex assembly with scaffold proteins leading to exclusion from stress granules. For which... | glioma | Medium | convergence | {"qa_id":"medium_convergence_00126","source_qa_id":"medium_convergence_two_branch_unequal_context_0055","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"MUC12 and ZFP36 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00127 | HNF4G and NQO1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes binding of a quinone oxidoreductase to a proto-oncogene protein resulting in robust accumulation by blocking a ubiquitin degradation pathway. Which di... | fibrodysplasia ossificans progressiva | Medium | convergence | {"qa_id":"medium_convergence_00127","source_qa_id":"medium_convergence_two_branch_unequal_context_0421","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"HNF4G and NQO1 have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00128 | West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in monocytes with a log2 fold-change of about 5.66 and an adjusted p-value of about 0.007. For which disease is this gene reported as a biomarker? | asthma | Medium | convergence | {"qa_id":"medium_convergence_00128","source_qa_id":"medium_convergence_two_branch_equal_context_1113","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. E... | |
medium_convergence_00129 | TOM1L1 and TOM1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes direct interactions between the C-terminal regions of a family of sorting proteins and clathrin heavy chains. Which disease is linked to genomic alterations in this protein's gene? | inflammatory myofibroblastic tumor | Medium | convergence | {"qa_id":"medium_convergence_00129","source_qa_id":"medium_convergence_two_branch_equal_context_0080","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"TOM1L1 and TOM1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00130 | Human orthopneumovirus and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in a monocytic leukemia cell line with a log2 fold-change of about -1.13 and an adjusted p-value of about 0.02. For which disease is this gene reporte... | liver cancer | Medium | convergence | {"qa_id":"medium_convergence_00130","source_qa_id":"medium_convergence_two_branch_equal_context_1223","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human orthopneumovirus and Human alphaherpesvirus 1 alter the expression of several genes in c... | |
medium_convergence_00131 | C10orf67 and NOD1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes binding of a caspase recruitment domain to ubiquitin in addition to direct binding of downstream signaling targets. For which disease is this prote... | escherichia coli infection | Medium | convergence | {"qa_id":"medium_convergence_00131","source_qa_id":"medium_convergence_two_branch_unequal_context_0229","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"C10orf67 and NOD1 have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00132 | INSIG1 and RPN1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a direct physical interaction between a progesterone binding membrane protein and a key regulator of cholesterol homeostasis. For which disease is this protein reported as a biomarker? | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_00132","source_qa_id":"medium_convergence_two_branch_equal_context_0502","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"INSIG1 and RPN1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00133 | THAP11 and SP1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes an interaction between a transcription factor and a proteasome ATPase subunit demonstrated through in vitro and in vivo studies. Which disease is associated with this protein? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00133","source_qa_id":"medium_convergence_two_branch_equal_context_0972","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"THAP11 and SP1 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00134 | KPTN and RBCK1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes how a ring finger protein functions as an e3 ligase for oxidized iron regulatory protein suggesting oxidation is a recognition signal for ubiquitinati... | alpha 1-antitrypsin deficiency | Medium | convergence | {"qa_id":"medium_convergence_00134","source_qa_id":"medium_convergence_two_branch_unequal_context_0664","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"KPTN and RBCK1 have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00135 | West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a melanoma cell line with a log2 fold-change of about 5.21 and an adjusted p-value of about 4.9e-13. For which disease is this gene reported as a biomarker? | asthma | Medium | convergence | {"qa_id":"medium_convergence_00135","source_qa_id":"medium_convergence_two_branch_equal_context_1091","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. ... | |
medium_convergence_00136 | DCAF12L1 and SMARCA4 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes interactions between Smad proteins and core SWI/SNF chromatin-remodeling complex components BRG1 BAF250b BAF170 and BAF155. Which disease is lin... | cervical carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00136","source_qa_id":"medium_convergence_two_branch_unequal_context_0856","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"DCAF12L1 and SMARCA4 have overlapping extended protein-interaction neighborhoods containin... | |
medium_convergence_00137 | Several genes responsive to Rhinovirus A exposure encode proteins within the extended interaction neighborhood of TGFB1I1. Expression data distinguish one of these genes: it was upregulated in cytotoxic T cells with a log2 fold-change of about 1.14 and an adjusted p-value of about 0.03. Which disease is associated with... | male breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00137","source_qa_id":"medium_convergence_two_branch_unequal_context_1213","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"Several genes responsive to Rhinovirus A exposure encode proteins within the extended inte... | |
medium_convergence_00138 | INSRR, SDF2L1, and SOCS1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a strong physical interaction between a suppressor of cytokine signaling protein and an insulin-like growth factor receptor as demonstrated by a yeast two-hybrid assay. Which disease has a t... | prostate adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00138","source_qa_id":"medium_convergence_three_branch_context_0135","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"INSRR, SDF2L1, and SOCS1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00139 | CLEC1B and RAF1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical association between a receptor for activated C kinase and the cytoplasmic tail of a C type lectin domain family member. Which disease is linked to genomic alterations in this protein's gen... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00139","source_qa_id":"medium_convergence_two_branch_equal_context_0702","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CLEC1B and RAF1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00140 | CD22 and BCAR1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes selective inhibition of growth factor induced phosphorylation and complex formation between a scaffolding protein and an adaptor protein by a phosphatase. Which disease is linked to genomic alteration... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00140","source_qa_id":"medium_convergence_two_branch_equal_context_0724","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CD22 and BCAR1 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00141 | HRSP12 and FAF1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins cautiously suggests an association between a ubiquitin-like protein and a heat shock protein that is linked to tumor formation despite unknown molecular mechan... | Parkinson disease | Medium | convergence | {"qa_id":"medium_convergence_00141","source_qa_id":"medium_convergence_two_branch_unequal_context_0549","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"HRSP12 and FAF1 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00142 | NPHP3 and PTPRC have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the confirmation of a trimolecular complex containing a receptor tyrosine phosphatase, a src family kinase, and a thirty four kilodalton protein. Whi... | type 1 diabetes mellitus 1 | Medium | convergence | {"qa_id":"medium_convergence_00142","source_qa_id":"medium_convergence_two_branch_unequal_context_0299","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"NPHP3 and PTPRC have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00143 | BATF2 and STUB1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a direct physical interaction between a chaperone protein and specific signaling mediators demonstrated through an in vitro binding assay using label... | cleidocranial dysplasia 1 | Medium | convergence | {"qa_id":"medium_convergence_00143","source_qa_id":"medium_convergence_two_branch_unequal_context_0772","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BATF2 and STUB1 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00144 | ZNF281, ELMSAN1, and RALY share more than one reported protein partner. Evidence concerning one of these shared proteins describes a zinc finger protein physically interacting with three core transcription factors essential for maintaining pluripotency in stem cells. Which disease has a causal association with this pro... | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00144","source_qa_id":"medium_convergence_three_branch_context_0247","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ZNF281, ELMSAN1, and RALY share more than one reported protein partner. Evidence concerning one of the... | |
medium_convergence_00145 | IGFBP3 and PARK7 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a drug-induced complex formation between a DNA/RNA-binding protein and its dimerization partner with an insulin-like growth factor binding protein in basal-like breast cancer cells. For which diseas... | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00145","source_qa_id":"medium_convergence_two_branch_equal_context_0098","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"IGFBP3 and PARK7 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00146 | Human respirovirus 3 and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in a monocytic leukemia cell line with a log2 fold-change of about -1.07 and an adjusted p-value of about 0.01. Which disease is associated with this ge... | testicular cancer | Medium | convergence | {"qa_id":"medium_convergence_00146","source_qa_id":"medium_convergence_two_branch_equal_context_1247","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human respirovirus 3 and Human alphaherpesvirus 1 alter the expression of several genes in com... | |
medium_convergence_00147 | West Nile virus and Enterovirus A alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in rhabdomyosarcoma cells with a log2 fold-change of about -3.37 and an adjusted p-value of about 0.015. For which disease is this gene reported as a biomarker? | hypercholesterolemia, familial, 4 | Medium | convergence | {"qa_id":"medium_convergence_00147","source_qa_id":"medium_convergence_two_branch_equal_context_1093","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Enterovirus A alter the expression of several genes in common. Expression ... | |
medium_convergence_00148 | ENTHD1 and KIF5B have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the confirmation that a nonneuronal homologue of a synaptosome-associated protein interacts with a motor protein involved in intracellular transport... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00148","source_qa_id":"medium_convergence_two_branch_unequal_context_0929","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"ENTHD1 and KIF5B have overlapping extended protein-interaction neighborhoods containing se... | |
medium_convergence_00149 | HSPE1, NR3C1, and GAPDH share more than one reported protein partner. Evidence concerning one of these shared proteins describes the identification of pyruvate dehydrogenase and a heat shock protein as potent binding partners for mitochondrial glucocorticoid receptor. Which disease has a therapeutic association with th... | cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00149","source_qa_id":"medium_convergence_three_branch_context_0599","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"HSPE1, NR3C1, and GAPDH share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00150 | TBC1D9 and ATG4B share more than one reported protein partner. Evidence concerning one of these shared proteins describes a C-terminal motif within a specific protease that facilitates efficient binding to and cleavage of ubiquitin-like proteins involved in autophagy. For which disease is this protein reported as a bio... | hyperphosphatemia | Medium | convergence | {"qa_id":"medium_convergence_00150","source_qa_id":"medium_convergence_two_branch_equal_context_0126","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"TBC1D9 and ATG4B share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00151 | ZNF281, ELMSAN1, and PDCD11 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a zinc finger protein physically interacting with three core transcription factors essential for maintaining pluripotency in stem cells. Which disease has a causal association with this p... | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00151","source_qa_id":"medium_convergence_three_branch_context_0205","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ZNF281, ELMSAN1, and PDCD11 share more than one reported protein partner. Evidence concerning one of t... | |
medium_convergence_00152 | CLEC1B and ALK share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical association between a receptor for activated C kinase and the cytoplasmic tail of a C type lectin domain family member. Which disease is linked to genomic alterations in this protein's gene... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00152","source_qa_id":"medium_convergence_two_branch_equal_context_0700","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CLEC1B and ALK share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00153 | Several genes responsive to Rhinovirus A exposure encode proteins within the extended interaction neighborhood of UBE2I. Expression data distinguish one of these genes: it was upregulated in cytotoxic T cells with a log2 fold-change of about 1.01 and an adjusted p-value of about 0.022. Which disease is linked to genomi... | glioma | Medium | convergence | {"qa_id":"medium_convergence_00153","source_qa_id":"medium_convergence_two_branch_unequal_context_1235","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"Several genes responsive to Rhinovirus A exposure encode proteins within the extended inte... | |
medium_convergence_00154 | Human alphaherpesvirus 3 and Human respirovirus 3 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a non-small cell lung adenocarcinoma cell line with a log2 fold-change of about 1.22 and an adjusted p-value of about 0.042. Which disease is associate... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00154","source_qa_id":"medium_convergence_two_branch_equal_context_1175","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human alphaherpesvirus 3 and Human respirovirus 3 alter the expression of several genes in com... | |
medium_convergence_00155 | TDRD3 and MIB1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a methylarginine recognizing protein recruiting a topoisomerase to relax supercoiled DNA and prevent R-loop formation. For which disease is this protein reported as a biomarker? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00155","source_qa_id":"medium_convergence_two_branch_equal_context_0872","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"TDRD3 and MIB1 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00156 | ZNF281, SAP130, and GCN1L1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a zinc finger protein physically interacting with three core transcription factors essential for maintaining pluripotency in stem cells. Which disease has a causal association with this pr... | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00156","source_qa_id":"medium_convergence_three_branch_context_0255","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ZNF281, SAP130, and GCN1L1 share more than one reported protein partner. Evidence concerning one of th... | |
medium_convergence_00157 | West Nile virus and Rhinovirus A alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in cytotoxic T cells with a log2 fold-change of about -4.78 and an adjusted p-value of about 0.00078. For which disease is this gene reported as a biomarker? | asthma | Medium | convergence | {"qa_id":"medium_convergence_00157","source_qa_id":"medium_convergence_two_branch_equal_context_1081","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Rhinovirus A alter the expression of several genes in common. Expression d... | |
medium_convergence_00158 | DEFB124 and CREBBP have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a histone acetyltransferase interacting with and acetylating a component of the MutL alpha complex. For which disease is this protein reported as ... | germ cell tumor | Medium | convergence | {"qa_id":"medium_convergence_00158","source_qa_id":"medium_convergence_two_branch_unequal_context_0173","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"DEFB124 and CREBBP have overlapping extended protein-interaction neighborhoods containing ... | |
medium_convergence_00159 | West Nile virus and Primate bocaparvovirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in tracheobronchial epithelial cells with a log2 fold-change of about 1.69 and an adjusted p-value of about 0.0055. For which disease is this gene reported as ... | asthma | Medium | convergence | {"qa_id":"medium_convergence_00159","source_qa_id":"medium_convergence_two_branch_equal_context_1087","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Primate bocaparvovirus 1 alter the expression of several genes in common. ... | |
medium_convergence_00160 | NRF1 and NCOR1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the experimental confirmation of a molecular interaction using both immunoprecipitation and chromatin immunoprecipitation techniques to validate binding. Which disease is associated with this protein? | chondrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_00160","source_qa_id":"medium_convergence_two_branch_equal_context_0208","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"NRF1 and NCOR1 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00161 | CLEC1B and YTHDF2 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical association between a receptor for activated C kinase and the cytoplasmic tail of a C type lectin domain family member. Which disease is linked to genomic alterations in this protein's g... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00161","source_qa_id":"medium_convergence_two_branch_equal_context_0699","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CLEC1B and YTHDF2 share more than one reported protein partner. Evidence concerning one of the... | |
medium_convergence_00162 | INSRR, SOCS1, and KRAS share more than one reported protein partner. Evidence concerning one of these shared proteins describes a strong physical interaction between a suppressor of cytokine signaling protein and an insulin-like growth factor receptor detected via yeast two-hybrid assay. Which disease has a therapeutic... | prostate adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00162","source_qa_id":"medium_convergence_three_branch_context_0138","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"INSRR, SOCS1, and KRAS share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00163 | West Nile virus and Rhinovirus A alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in cytotoxic T cells with a log2 fold-change of about -4.00 and an adjusted p-value of about 0.0044. For which disease is this gene reported as a biomarker? | squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00163","source_qa_id":"medium_convergence_two_branch_equal_context_1082","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Rhinovirus A alter the expression of several genes in common. Expression d... | |
medium_convergence_00164 | KLF2, SREBF1, and CTNNB1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a HECT-type ubiquitin ligase interacting with a transcription factor to target it for poly-ubiquitination and proteasomal degradation in cells of a specific malignancy. For which disease is ... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_00164","source_qa_id":"medium_convergence_three_branch_context_0965","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"KLF2, SREBF1, and CTNNB1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00165 | HSPE1, ATP5A1, and NR3C1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the identification of pyruvate dehydrogenase and a heat shock protein as potent binding partners for mitochondrial glucocorticoid receptor. Which disease has a therapeutic association with t... | cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00165","source_qa_id":"medium_convergence_three_branch_context_0597","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"HSPE1, ATP5A1, and NR3C1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00166 | RBM7 and ZNF281 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the physical interaction of a zinc finger protein with three core pluripotency transcription factors including Oct4 and Nanog as demonstrated by experimental data. Which disease has a causal associat... | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00166","source_qa_id":"medium_convergence_two_branch_equal_context_0581","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"RBM7 and ZNF281 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00167 | NOD1 and NOD2 share more than one reported protein partner. Evidence concerning one of these shared proteins describes how a caspase recruitment domain binds ubiquitin and directly interacts with a kinase and an autophagy-related protein. For which disease is this protein reported as a biomarker? | escherichia coli infection | Medium | convergence | {"qa_id":"medium_convergence_00167","source_qa_id":"medium_convergence_two_branch_equal_context_0913","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"NOD1 and NOD2 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00168 | AKAP8L, LMNA, and TOPBP1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a lamina binding partner exhibiting strong affinity for pocket C and weak affinity for pocket B within the nuclear structural framework. Which disease is linked to genomic alterations in thi... | familial dilated cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00168","source_qa_id":"medium_convergence_three_branch_context_0959","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"AKAP8L, LMNA, and TOPBP1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00169 | GLP1R, CKAP4, and SEC61B share more than one reported protein partner. Evidence concerning one of these shared proteins describes the validation of three novel interactors for a glucagon-like peptide one receptor using co-immunoprecipitation fluorescence resonance energy transfer and immunofluorescence. For which disea... | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_00169","source_qa_id":"medium_convergence_three_branch_context_0506","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"GLP1R, CKAP4, and SEC61B share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00170 | ARHGAP19 and ZFP36 share more than one reported protein partner. Evidence concerning one of these shared proteins describes how kinase induced phosphorylation at specific serines promotes complex assembly and causes exclusion from stress granules. For which disease is this protein reported as a biomarker? | glioma | Medium | convergence | {"qa_id":"medium_convergence_00170","source_qa_id":"medium_convergence_two_branch_equal_context_0065","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"ARHGAP19 and ZFP36 share more than one reported protein partner. Evidence concerning one of th... | |
medium_convergence_00171 | GRPEL2 and STUB1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a cytosolic U-box protein interacting with a heat shock cognate protein through a set of tetratricorepeat motifs. Which disease has a causal associa... | proteinuria | Medium | convergence | {"qa_id":"medium_convergence_00171","source_qa_id":"medium_convergence_two_branch_unequal_context_0848","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"GRPEL2 and STUB1 have overlapping extended protein-interaction neighborhoods containing se... | |
medium_convergence_00172 | DFNB31 and BCAR1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the ability of a fusion oncoprotein to bind and induce phosphorylation of an adaptor protein in various cell types. Which disease has a causal assoc... | hereditary hemorrhagic telangiectasia | Medium | convergence | {"qa_id":"medium_convergence_00172","source_qa_id":"medium_convergence_two_branch_unequal_context_0256","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"DFNB31 and BCAR1 have overlapping extended protein-interaction neighborhoods containing se... | |
medium_convergence_00173 | DCAF12L1 and CREBBP have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes direct interactions between a specific CBP fragment and Smad homotrimers or heterotrimers to form larger protein complexes. Which disease is link... | cervical carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00173","source_qa_id":"medium_convergence_two_branch_unequal_context_0855","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"DCAF12L1 and CREBBP have overlapping extended protein-interaction neighborhoods containing... | |
medium_convergence_00174 | PIK3AP1 and DNM1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes SH3 domains binding to the proline-rich region of a large GTPase involved in membrane fission. Which disease is linked to genomic alterations in this protein's gene? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00174","source_qa_id":"medium_convergence_two_branch_equal_context_0727","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"PIK3AP1 and DNM1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00175 | NLRC4 and SHOC2 share more than one reported protein partner. Evidence concerning one of these shared proteins describes how an ATPase binding partner triggers the translocation of a signaling protein to endosomal compartments. Which disease is associated with this protein? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00175","source_qa_id":"medium_convergence_two_branch_equal_context_0970","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"NLRC4 and SHOC2 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00176 | CENPW and CDC34 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a truncated protein fragment binding to specific ubiquitin ligase components at levels comparable to the full-length wildtype protein. For which disease is this protein reported as a biomarker? | malignant pleural mesothelioma | Medium | convergence | {"qa_id":"medium_convergence_00176","source_qa_id":"medium_convergence_two_branch_equal_context_0782","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CENPW and CDC34 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00177 | FIS1 and VCP share more than one reported protein partner. Evidence concerning one of these shared proteins describes interaction with an endoplasmic reticulum membrane protein to facilitate its cleavage into a pro-apoptotic fragment. For which disease is this protein reported as a biomarker? | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_00177","source_qa_id":"medium_convergence_two_branch_equal_context_0131","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"FIS1 and VCP share more than one reported protein partner. Evidence concerning one of these sh... | |
medium_convergence_00178 | MAP4K5, CBLC, and ASAP1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the formation of a trimeric protein complex involving an adaptor protein along with this shared protein and paxillin. Which disease is associated with this shared protein? | ethmoid sinus adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00178","source_qa_id":"medium_convergence_three_branch_context_0347","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"MAP4K5, CBLC, and ASAP1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00179 | FIS1 and RPA3 share more than one reported protein partner. Evidence concerning one of these shared proteins describes interaction with an endoplasmic reticulum membrane protein to facilitate its cleavage into a pro-apoptotic fragment. For which disease is this protein reported as a biomarker? | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_00179","source_qa_id":"medium_convergence_two_branch_equal_context_0130","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"FIS1 and RPA3 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00180 | ZMIZ1, NLK, and AKT1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a direct physical interaction mediated by a tetratricopeptide repeat domain at specific regulatory sites. Which disease has a causal association with this protein? | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00180","source_qa_id":"medium_convergence_three_branch_context_0397","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ZMIZ1, NLK, and AKT1 share more than one reported protein partner. Evidence concerning one of these sh... | |
medium_convergence_00181 | CD22 and KHDRBS1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a drug disrupting in vivo interactions between an RNA binding protein and other SH3 domain containing proteins. Which disease is linked to genomic alterations in this protein's gene? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00181","source_qa_id":"medium_convergence_two_branch_equal_context_0726","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CD22 and KHDRBS1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00182 | Human mastadenovirus C and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in a monocytic leukemia cell line with a log2 fold-change of about -1.13 and an adjusted p-value of about 0.0063. Which disease is associated with thi... | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00182","source_qa_id":"medium_convergence_two_branch_equal_context_1074","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human mastadenovirus C and Human alphaherpesvirus 1 alter the expression of several genes in c... | |
medium_convergence_00183 | West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in dendritic cells with a log2 fold-change of about 5.99 and an adjusted p-value of about 0.014. Which disease is associated with this gene? | thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_00183","source_qa_id":"medium_convergence_two_branch_equal_context_1109","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. E... | |
medium_convergence_00184 | West Nile virus and Zaire ebolavirus alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a retinal pigment epithelium cell line with a log2 fold-change of about 5.27 and an adjusted p-value of about 0.00037. Which disease is associated with this gene? | thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_00184","source_qa_id":"medium_convergence_two_branch_equal_context_1115","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Zaire ebolavirus alter the expression of several genes in common. Expressi... | |
medium_convergence_00185 | PPIH, USP4, and TRIM25 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a ternary complex formed by two deubiquitinases and a ribosomal protein serving as a platform for substrate deubiquitination. For which disease is this protein reported as a biomarker? | Moyamoya disease | Medium | convergence | {"qa_id":"medium_convergence_00185","source_qa_id":"medium_convergence_three_branch_context_0938","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"PPIH, USP4, and TRIM25 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00186 | MME and CDK1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the immunoprecipitation of a phosphoprotein with a specific antibody to confirm its identity as a src-related kinase. Which disease is linked to genomic alterations in this protein's gene? | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00186","source_qa_id":"medium_convergence_two_branch_equal_context_0413","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"MME and CDK1 share more than one reported protein partner. Evidence concerning one of these sh... | |
medium_convergence_00187 | IL5RA and PTPRC have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes confirmation of a trimolecular complex containing a receptor tyrosine phosphatase and a src family kinase in t cells. Which disease is linked to geno... | type 1 diabetes mellitus 1 | Medium | convergence | {"qa_id":"medium_convergence_00187","source_qa_id":"medium_convergence_two_branch_unequal_context_0469","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"IL5RA and PTPRC have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00188 | COPS7B and CUL4B both interact with a shared protein partner. Evidence indicates that this shared partner is required for the formation of a functional DDB1-containing E3 ligase complex that binds to UV-damaged chromatin. Which protein is encoded by the gene corresponding to this shared partner? | DNA damage-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00188","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS7B and CUL4B both interact with a shared protein partner. Evidence indicates that this shared partner is required for the formation of a functional DDB1-... | |
medium_convergence_00189 | Monocyte chemotaxis and macrophage migration are both subtypes of a shared biological process. Evidence regarding this shared process describes 'The movement of a monocyte in response to an external stimulus.' Which cell type is the direct result of the movement described by this shared process? | myeloid leukocyte | Medium | convergence | {"qa_id":"medium_convergence_00189","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Monocyte chemotaxis and macrophage migration are both subtypes of a shared biological process. Evidence regarding this shared process describes 'The movement... | |
medium_convergence_00190 | PAXIP1 and HERC2 both interact with a common protein partner. Evidence indicates that in response to ionising radiation (IR), this shared partner forms a complex with HERC2 and functions as a ubiquitin ligase involved in the DNA damage response (DDR). Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase RNF8 | Medium | convergence | {"qa_id":"medium_convergence_00190","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAXIP1 and HERC2 both interact with a common protein partner. Evidence indicates that in response to ionising radiation (IR), this shared partner forms a com... | |
medium_convergence_00191 | AKT1S1 and LAMTOR3 both interact with a common protein complex component. Evidence indicates that PRAS40 binds to this component in insulin-deprived cells, and this interaction is disrupted by high salt concentrations. Which protein is encoded by the gene corresponding to this shared interaction partner? | Serine/threonine-protein kinase mTOR | Medium | convergence | {"qa_id":"medium_convergence_00191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1S1 and LAMTOR3 both interact with a common protein complex component. Evidence indicates that PRAS40 binds to this component in insulin-deprived cells, a... | |
medium_convergence_00193 | DCP1A and EXOSC5 share a common interaction partner. Evidence indicates that mutation of six C-terminal lysines in this shared partner suppresses decapping activity and impairs its interaction with the mRNA decay factors DCP2, EDC4, and itself, but not EDC3, thereby remodeling P-body architecture. Which protein is enco... | 5'-3' exoribonuclease 1 | Medium | convergence | {"qa_id":"medium_convergence_00193","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCP1A and EXOSC5 share a common interaction partner. Evidence indicates that mutation of six C-terminal lysines in this shared partner suppresses decapping a... | |
medium_convergence_00194 | DDX17 and DDX3X both interact with a shared protein partner. Evidence indicates that sumoylation promotes the interaction of this shared partner and p72 with histone deacetylase 1, but has no effect on their binding to histone deacetylases 2 and 3, the coactivator p300, or estrogen receptor, nor does it affect the homo... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_00194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX17 and DDX3X both interact with a shared protein partner. Evidence indicates that sumoylation promotes the interaction of this shared partner and p72 with... | |
medium_convergence_00195 | KAT2B and HDAC4 both interact with a specific protein. Evidence indicates that this protein deacetylates PCAF in vitro and modulates PCAF acetylation in vivo. Which protein is encoded by the gene corresponding to this interacting entity? | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_00195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT2B and HDAC4 both interact with a specific protein. Evidence indicates that this protein deacetylates PCAF in vitro and modulates PCAF acetylation in vivo... | |
medium_convergence_00196 | CTNNB1 and MARK3 share a common interacting partner. Experimental evidence indicates that this shared partner directly binds to beta-catenin and forms a complex with 14-3-3 epsilon, zeta, and eta proteins. Which protein is encoded by this shared interacting partner? | Histone deacetylase 7 | Medium | convergence | {"qa_id":"medium_convergence_00196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and MARK3 share a common interacting partner. Experimental evidence indicates that this shared partner directly binds to beta-catenin and forms a comp... | |
medium_convergence_00198 | SIN3A and SP1 both interact with a specific protein. Evidence indicates that this protein interacts with SP1, binds to the p21(WAF1/Cip1) proximal promoter (which is rich in Sp1/Sp3 binding sites), and reduces histone H3 acetylation at this site. This activity suggests a key role for SP1 in the repression of p21(WAF1/C... | Histone deacetylase 4 | Medium | convergence | {"qa_id":"medium_convergence_00198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and SP1 both interact with a specific protein. Evidence indicates that this protein interacts with SP1, binds to the p21(WAF1/Cip1) proximal promoter (... | |
medium_convergence_00199 | NR3C1 and RELA share interaction partners. One such shared partner is implicated in a study where co-immunoprecipitation assays revealed that a specific histone methyltransferase is associated with GR in a ligand-independent manner in APRE-19 cells. Which protein encodes this shared interaction partner? | Histone-lysine N-methyltransferase 2D | Medium | convergence | {"qa_id":"medium_convergence_00199","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and RELA share interaction partners. One such shared partner is implicated in a study where co-immunoprecipitation assays revealed that a specific hist... | |
medium_convergence_00200 | CENPS and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a recently identified inner centromere component that plays crucial roles in the formation of a functional kinetochore involved in cell division during mitosis.' Whi... | Centromere protein W | Medium | convergence | {"qa_id":"medium_convergence_00200","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a ... | |
medium_convergence_00201 | Both Measles morbillivirus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 1.537 and an adjusted p-value of 0.0499. Which cellular component is the location of this gene? | phagophore assembly site | Medium | convergence | {"qa_id":"medium_convergence_00201","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold c... | |
medium_convergence_00202 | WWP2 and SMURF1 both interact with a specific shared protein. Evidence indicates that LMP-1, a LIM domain protein capable of inducing de novo bone formation, interacts with this shared entity (identified as Smad ubiquitin regulatory factor 1) and prevents the ubiquitination of Smads. Which protein is encoded by the gen... | PDZ and LIM domain protein 7 | Medium | convergence | {"qa_id":"medium_convergence_00202","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP2 and SMURF1 both interact with a specific shared protein. Evidence indicates that LMP-1, a LIM domain protein capable of inducing de novo bone formation,... | |
medium_convergence_00203 | CDC37 and HSP90AA1 both interact with a specific protein. Evidence indicates that Hsp90 and its co-chaperone p23 bind to this protein through its N-terminal double-stranded (ds) RNA binding region as well as through its kinase domain. Which protein is encoded by this gene? | Interferon-induced, double-stranded RNA-activated protein kinase | Medium | convergence | {"qa_id":"medium_convergence_00203","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and HSP90AA1 both interact with a specific protein. Evidence indicates that Hsp90 and its co-chaperone p23 bind to this protein through its N-terminal ... |
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