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medium_hidden_intermediate_00099 | More than one protein that interacts with one of DEFB124's protein partners also interacts with CREBBP. Evidence concerning one possible intermediate entity describes a histone acetyltransferase interacting with and acetylating a component of the MutL alpha complex. For which disease is this entity reported as a biomar... | germ cell tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00099","source_qa_id":"medium_hidden_intermediate_09989","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of DEFB124's protein partners also interacts with... | |
medium_hidden_intermediate_00100 | More than one protein that interacts with one of DLL1's protein partners also interacts with MLLT4. Evidence concerning one possible intermediate entity describes coimmunoprecipitation of AF-6 with a tight junction component from Rat1 cells indicating physical association. For which disease is this entity reported as a... | urinary bladder neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00100","source_qa_id":"medium_hidden_intermediate_09609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of DLL1's protein partners also interacts with ML... | |
medium_hidden_intermediate_00101 | NOD1 and NOD2 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes how a caspase recruitment domain binds ubiquitin and directly interacts with a kinase and an autophagy-related protein. For which disease is this entity reported as a biomarker? | escherichia coli infection | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00101","source_qa_id":"medium_hidden_intermediate_07211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"NOD1 and NOD2 share more than one reported protein partner. Evidence concerning one possible in... | |
medium_hidden_intermediate_00102 | More than one protein that interacts with one of LRIG3's protein partners also interacts with SNCA. Evidence concerning one possible intermediate entity describes selective interaction of a synuclein protein with neurotrophic receptors leading to inhibited signaling and subsequent neuronal death. Which disease is linke... | Alzheimer disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00102","source_qa_id":"medium_hidden_intermediate_07866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of LRIG3's protein partners also interacts with S... | |
medium_hidden_intermediate_00103 | PIK3AP1 and ADAM15 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes the cytoplasmic domain of a metalloprotease interacting specifically with Src family kinases and an adaptor protein in hematopoietic cells. Which disease is linked to genomic alterations in th... | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00103","source_qa_id":"medium_hidden_intermediate_07284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"PIK3AP1 and ADAM15 share more than one reported protein partner. Evidence concerning one possib... | |
medium_hidden_intermediate_00104 | FIS1 and RPA3 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes interaction with an endoplasmic reticulum membrane protein to facilitate its cleavage into a pro-apoptotic fragment. For which disease is this entity reported as a biomarker? | cervical cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00104","source_qa_id":"medium_hidden_intermediate_07464","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"FIS1 and RPA3 share more than one reported protein partner. Evidence concerning one possible in... | |
medium_hidden_intermediate_00105 | West Nile virus and Human betaherpesvirus 5 affect the expression of more than one gene in common; West Nile virus upregulates these genes, whereas Human betaherpesvirus 5 upregulates them. Expression metadata for one possible intermediate entity show that it was upregulated in monocyte with a log2 fold-change of about... | asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00105","source_qa_id":"medium_hidden_intermediate_08724","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"West Nile virus and Human betaherpesvirus 5 affect the expression of more than one gene in comm... | |
medium_hidden_intermediate_00106 | More than one protein that interacts with one of CERS1's protein partners also interacts with ATG7. Evidence concerning one possible intermediate entity describes physical association between a proteasome subunit and an autophagy enzyme in cytoplasm enhanced by nutrient deprivation. Which disease is associated with thi... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00106","source_qa_id":"medium_hidden_intermediate_09359","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of CERS1's protein partners also interacts with A... | |
medium_hidden_intermediate_00107 | CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one possible intermediate entity describes specific direct binding of adaptor molecules to a regulatory protein in the cytoplasm to participate in its regulation. Which disease is linked to genomic alterations in this entity's gene? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00107","source_qa_id":"medium_hidden_intermediate_08320","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one possible ... | |
medium_hidden_intermediate_00108 | More than one protein that interacts with one of GRIN2C's protein partners also interacts with PTPN11. Evidence concerning one possible intermediate entity describes the rapid recruitment of a phosphatase to a receptor leading to substrate dephosphorylation and complex dissociation upon ligand stimulation. Which diseas... | cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00108","source_qa_id":"medium_hidden_intermediate_09502","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of GRIN2C's protein partners also interacts with ... | |
medium_hidden_intermediate_00109 | TBC1D9 and ATG7 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes three human counterparts of a yeast protein that coimmunoprecipitate with an E1 enzyme and form stable ester bond intermediates with a mutant form. For which disease is this entity reported as a ... | hyperphosphatemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00109","source_qa_id":"medium_hidden_intermediate_09011","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"TBC1D9 and ATG7 share more than one reported protein partner. Evidence concerning one possible ... | |
medium_hidden_intermediate_00110 | USP26 and TP53 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes an elongation factor coimmunoprecipitating in a salt stable complex with a tumor suppressor protein. For which disease is this entity reported as a biomarker? | myocardial ischemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00110","source_qa_id":"medium_hidden_intermediate_09560","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"USP26 and TP53 share more than one reported protein partner. Evidence concerning one possible i... | |
medium_hidden_intermediate_00111 | Human gammaherpesvirus 4 and Human alphaherpesvirus 1 affect the expression of more than one gene in common; Human gammaherpesvirus 4 downregulates these genes, whereas Human alphaherpesvirus 1 downregulates them. Expression metadata for one possible intermediate entity show that it was downregulated in monocytic leuke... | esophageal adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00111","source_qa_id":"medium_hidden_intermediate_07073","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"Human gammaherpesvirus 4 and Human alphaherpesvirus 1 affect the expression of more than one ge... | |
medium_hidden_intermediate_00112 | More than one protein that interacts with one of LTB4R's protein partners also interacts with MTOR. Evidence concerning one possible intermediate entity describes the direct binding of an oncogenic GTPase to kinase complex components to promote enzymatic activity at the plasma membrane. For which disease is this entity... | renal fibrosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00112","source_qa_id":"medium_hidden_intermediate_09758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of LTB4R's protein partners also interacts with M... | |
medium_hidden_intermediate_00113 | GTF3C5 and CDC6 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes how a cyclin interacts with a replication factor via defined motifs to promote its ubiquitylation and subsequent degradation. Which disease is linked to genomic alterations in this entity's gene? | amyotrophic lateral sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00113","source_qa_id":"medium_hidden_intermediate_08824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"GTF3C5 and CDC6 share more than one reported protein partner. Evidence concerning one possible ... | |
medium_hidden_intermediate_00114 | More than one protein that interacts with one of ADRBK2's protein partners also interacts with MAP3K5. Evidence concerning one possible intermediate entity describes physical association of beta-Arrestins with the C-terminal domain of an apoptosis signal-regulating kinase. Which disease is associated with this entity? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00114","source_qa_id":"medium_hidden_intermediate_07717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of ADRBK2's protein partners also interacts with ... | |
medium_hidden_intermediate_00115 | NLRC4 and TP53 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a physical interaction between a proteasome regulatory subunit and a tumor suppressor protein in both cellular and cell-free systems. Which disease is associated with this entity? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00115","source_qa_id":"medium_hidden_intermediate_08209","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"NLRC4 and TP53 share more than one reported protein partner. Evidence concerning one possible i... | |
medium_hidden_intermediate_00116 | LSM8 and USP4 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a ternary complex formation between two deubiquitinating enzymes and an adaptor that serves as a platform for substrate deubiquitination. For which disease is this entity reported as a biomarker? | Moyamoya disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00116","source_qa_id":"medium_hidden_intermediate_08402","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"LSM8 and USP4 share more than one reported protein partner. Evidence concerning one possible in... | |
medium_hidden_intermediate_00117 | CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a conserved tyrosine residue in a cdk binding domain being phosphorylated by a src family kinase and an oncogene product. Which disease is linked to genomic alterations in this entity's gene? | diffuse large B-cell lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00117","source_qa_id":"medium_hidden_intermediate_09156","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one possible ... | |
medium_hidden_intermediate_00118 | More than one protein that interacts with one of DOK7's protein partners also interacts with NEDD9. Evidence concerning one possible intermediate entity describes specific binding of a kinase to a proline-rich sequence at the C-terminus of an adaptor protein. Which disease is linked to genomic alterations in this entit... | diffuse large B-cell lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00118","source_qa_id":"medium_hidden_intermediate_07756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of DOK7's protein partners also interacts with NE... | |
medium_hidden_intermediate_00119 | Human gammaherpesvirus 4 and Human alphaherpesvirus 1 affect the expression of more than one gene in common; Human gammaherpesvirus 4 downregulates these genes, whereas Human alphaherpesvirus 1 downregulates them. Expression metadata for one possible intermediate entity show that it was downregulated in monocytic leuke... | depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00119","source_qa_id":"medium_hidden_intermediate_07444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"Human gammaherpesvirus 4 and Human alphaherpesvirus 1 affect the expression of more than one ge... | |
medium_hidden_intermediate_00120 | HSPE1, NR3C1, and GAPDH share more than one reported protein partner. Evidence concerning one possible intermediate entity describes the identification of pyruvate dehydrogenase and a heat shock protein as potent binding partners for mitochondrial glucocorticoid receptor. For which disease is this entity therapeuticall... | cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00120","source_qa_id":"medium_hidden_intermediate_09080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"HSPE1, NR3C1, and GAPDH share more than one reported protein partner. Evidence concerning one p... | |
medium_hidden_intermediate_00121 | NR4A2 and SP1 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a ubiquitous transcription activator interacting with a chromatin remodeling complex in vivo to augment promoter activation mediated by that complex. For which disease is this entity reported as a ... | arteriosclerosis disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00121","source_qa_id":"medium_hidden_intermediate_07867","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"NR4A2 and SP1 share more than one reported protein partner. Evidence concerning one possible in... | |
medium_hidden_intermediate_00122 | More than one protein that interacts with one of C9orf43's protein partners also interacts with ATG7. Evidence concerning one possible intermediate entity describes human counterparts of a yeast protein that coimmunoprecipitate with an E1 activating enzyme and form stable intermediates via ester bonds. For which diseas... | hyperphosphatemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00122","source_qa_id":"medium_hidden_intermediate_07995","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of C9orf43's protein partners also interacts with... | |
medium_hidden_intermediate_00123 | RASA1 and SOCS3 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes an association between the IGF-I receptor and p85 Syp and GAP but not with PLC-gamma in lysates of cells overexpressing the human IGF-I receptor. For which disease is this entity therapeutically ... | prostate adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00123","source_qa_id":"medium_hidden_intermediate_08728","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"RASA1 and SOCS3 share more than one reported protein partner. Evidence concerning one possible ... | |
medium_hidden_intermediate_00124 | AKAP8L, LMNA, and MYC share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a lamina binding partner exhibiting strong affinity for pocket C and weak affinity for pocket B within the nuclear structural framework. Which disease is linked to genomic alterations in th... | familial dilated cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00124","source_qa_id":"medium_hidden_intermediate_07316","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"AKAP8L, LMNA, and MYC share more than one reported protein partner. Evidence concerning one pos... | |
medium_hidden_intermediate_00125 | West Nile virus and Human betaherpesvirus 5 affect the expression of more than one gene in common; West Nile virus upregulates these genes, whereas Human betaherpesvirus 5 upregulates them. Expression metadata for one possible intermediate entity show that it was upregulated in foreskin fibroblast cell line with a log2... | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00125","source_qa_id":"medium_hidden_intermediate_08897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"West Nile virus and Human betaherpesvirus 5 affect the expression of more than one gene in comm... | |
medium_hidden_intermediate_00126 | DGCR8, RPS3, and FUS share more than one reported protein partner. Evidence concerning one possible intermediate entity describes C-terminal region interacting with FUS and SMN regulators of RNA processing. For which disease is this entity reported as a biomarker? | nasopharyngeal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00126","source_qa_id":"medium_hidden_intermediate_09328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"DGCR8, RPS3, and FUS share more than one reported protein partner. Evidence concerning one poss... | |
medium_hidden_intermediate_00127 | More than one protein that interacts with one of HEYL's protein partners also interacts with VHL. Evidence concerning one possible intermediate entity describes how reducing the levels of a deubiquitinase decreases the interaction between a dishevelled protein and a von Hippel Lindau tumor suppressor. Which disease is ... | osteoarthritis, knee | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00127","source_qa_id":"medium_hidden_intermediate_09757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of HEYL's protein partners also interacts with VH... | |
medium_hidden_intermediate_00128 | More than one protein that interacts with one of MUC12's protein partners also interacts with USP7. Evidence concerning one possible intermediate entity describes direct interaction between a deubiquitinase and a checkpoint ligand that serves to stabilize the ligand protein levels. Which disease has a causal associatio... | enteritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00128","source_qa_id":"medium_hidden_intermediate_09076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of MUC12's protein partners also interacts with U... | |
medium_hidden_intermediate_00129 | More than one protein that interacts with one of HNF4G's protein partners also interacts with NQO1. Evidence concerning one possible intermediate entity describes binding of a quinone oxidoreductase to a proto-oncogene protein resulting in robust accumulation by blocking a ubiquitin degradation pathway. Which disease h... | fibrodysplasia ossificans progressiva | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00129","source_qa_id":"medium_hidden_intermediate_08203","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of HNF4G's protein partners also interacts with N... | |
medium_hidden_intermediate_00130 | TBC1D16 and ATG7 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes three human counterparts of a yeast protein that coimmunoprecipitate with an E1 enzyme and form stable ester bond intermediates with a mutant form. For which disease is this entity reported as a... | hyperphosphatemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00130","source_qa_id":"medium_hidden_intermediate_09266","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"TBC1D16 and ATG7 share more than one reported protein partner. Evidence concerning one possible... | |
medium_hidden_intermediate_00131 | CLEC1B and CFTR share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a physical association between a receptor for activated C kinase and the cytoplasmic tail of a C type lectin domain family member. Which disease is linked to genomic alterations in this entity's ... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00131","source_qa_id":"medium_hidden_intermediate_09284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"CLEC1B and CFTR share more than one reported protein partner. Evidence concerning one possible ... | |
medium_hidden_intermediate_00132 | West Nile virus and Rhinovirus A affect the expression of more than one gene in common; West Nile virus upregulates these genes, whereas Rhinovirus A downregulates them. Expression metadata for one possible intermediate entity show that it was downregulated in cytotoxic T-lymphocyte with a log2 fold-change of about -4.... | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00132","source_qa_id":"medium_hidden_intermediate_07020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"West Nile virus and Rhinovirus A affect the expression of more than one gene in common; West Ni... | |
medium_hidden_intermediate_00133 | POU2F2 and SMARCE1 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes direct interactions made by a steroid receptor with specific chromatin remodeling complex subunits but not with other core subunits. For which disease is this entity therapeutically relevant? | asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00133","source_qa_id":"medium_hidden_intermediate_07637","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"POU2F2 and SMARCE1 share more than one reported protein partner. Evidence concerning one possib... | |
medium_hidden_intermediate_00134 | RAP1GAP and KRAS share more than one reported protein partner. Evidence concerning one possible intermediate entity describes in vivo interaction between a polo-like kinase and a GTPase activating protein mediated by recognition of a specific motif. Which disease is linked to genomic alterations in this entity's gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00134","source_qa_id":"medium_hidden_intermediate_07576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"RAP1GAP and KRAS share more than one reported protein partner. Evidence concerning one possible... | |
medium_hidden_intermediate_00135 | More than one protein that interacts with one of IL1RN's protein partners also interacts with PRAME. Evidence concerning one possible intermediate entity describes direct interaction with Elongin C and Golgi colocalization after PAMP and IFN gamma treatment. Which disease is associated with this entity? | renal cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00135","source_qa_id":"medium_hidden_intermediate_07881","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of IL1RN's protein partners also interacts with P... | |
medium_hidden_intermediate_00136 | Human respirovirus 3 and Human alphaherpesvirus 1 affect the expression of more than one gene in common; Human respirovirus 3 upregulates these genes, whereas Human alphaherpesvirus 1 downregulates them. Expression metadata for one possible intermediate entity show that it was downregulated in monocytic leukemia cell l... | testicular cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00136","source_qa_id":"medium_hidden_intermediate_09939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"Human respirovirus 3 and Human alphaherpesvirus 1 affect the expression of more than one gene i... | |
medium_hidden_intermediate_00137 | ARHGAP19 and ZFP36 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes how kinase induced phosphorylation at specific serines promotes complex assembly and causes exclusion from stress granules. For which disease is this entity reported as a biomarker? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00137","source_qa_id":"medium_hidden_intermediate_07697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"ARHGAP19 and ZFP36 share more than one reported protein partner. Evidence concerning one possib... | |
medium_hidden_intermediate_00138 | West Nile virus and Rhinovirus A affect the expression of more than one gene in common; West Nile virus upregulates these genes, whereas Rhinovirus A downregulates them. Expression metadata for one possible intermediate entity show that it was downregulated in cytotoxic T-lymphocyte with a log2 fold-change of about -3.... | thrombocytopenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00138","source_qa_id":"medium_hidden_intermediate_07745","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"West Nile virus and Rhinovirus A affect the expression of more than one gene in common; West Ni... | |
medium_hidden_intermediate_00139 | More than one protein that interacts with one of BATF2's protein partners also interacts with BTRC. Evidence concerning one possible intermediate entity describes an E3 ligase component interacting with a specific signaling mediator but not with related family members. Which disease has a causal association with this e... | cleidocranial dysplasia 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00139","source_qa_id":"medium_hidden_intermediate_08671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of BATF2's protein partners also interacts with B... | |
medium_hidden_intermediate_00140 | More than one protein that interacts with one of IL12RB2's protein partners also interacts with CBL. Evidence concerning one possible intermediate entity describes the formation of a signaling complex that translocates to lipid rafts in growth cones after stimulation. Which disease has a causal association with this en... | cone dystrophy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00140","source_qa_id":"medium_hidden_intermediate_09990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of IL12RB2's protein partners also interacts with... | |
medium_hidden_intermediate_00141 | ZNF281, SAP130, and GCN1L1 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a zinc finger protein physically interacting with three core transcription factors essential for maintaining pluripotency in stem cells. Which disease has a causal association with thi... | papillary adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00141","source_qa_id":"medium_hidden_intermediate_08921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"ZNF281, SAP130, and GCN1L1 share more than one reported protein partner. Evidence concerning on... | |
medium_hidden_intermediate_00142 | HSPE1, NR3C1, and MYH9 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes the identification of pyruvate dehydrogenase and a heat shock protein as potent binding partners for mitochondrial glucocorticoid receptor. For which disease is this entity therapeutically... | cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00142","source_qa_id":"medium_hidden_intermediate_08223","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"HSPE1, NR3C1, and MYH9 share more than one reported protein partner. Evidence concerning one po... | |
medium_hidden_intermediate_00143 | More than one protein that interacts with one of ENTHD1's protein partners also interacts with KIF5B. Evidence concerning one possible intermediate entity describes the confirmation that a nonneuronal homologue of a synaptosome-associated protein interacts with a motor protein involved in intracellular transport. For w... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00143","source_qa_id":"medium_hidden_intermediate_09195","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of ENTHD1's protein partners also interacts with ... | |
medium_hidden_intermediate_00144 | IGFBP3 and PARK7 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a drug-induced complex formation between a DNA/RNA-binding protein and its dimerization partner with an insulin-like growth factor binding protein in basal-like breast cancer cells. For which di... | kidney neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00144","source_qa_id":"medium_hidden_intermediate_07948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"IGFBP3 and PARK7 share more than one reported protein partner. Evidence concerning one possible... | |
medium_hidden_intermediate_00145 | HECW2 and NUP50 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes an interaction between an E3 ubiquitin ligase and a proliferating cell nuclear antigen via a canonical motif. For which disease is this entity reported as a biomarker? | histiocytic sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00145","source_qa_id":"medium_hidden_intermediate_07915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"HECW2 and NUP50 share more than one reported protein partner. Evidence concerning one possible ... | |
medium_hidden_intermediate_00146 | IGFBP3 and SART1 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes the formation of complexes between an RNA binding protein and its dimerization partner with an insulin like growth factor binding protein. For which disease is this entity reported as a biomarke... | kidney neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00146","source_qa_id":"medium_hidden_intermediate_08534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"IGFBP3 and SART1 share more than one reported protein partner. Evidence concerning one possible... | |
medium_hidden_intermediate_00147 | More than one protein that interacts with one of BATF2's protein partners also interacts with STUB1. Evidence concerning one possible intermediate entity describes a direct physical interaction between a chaperone protein and specific signaling mediators demonstrated through an in vitro binding assay using labeled prot... | cleidocranial dysplasia 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00147","source_qa_id":"medium_hidden_intermediate_08222","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of BATF2's protein partners also interacts with S... | |
medium_hidden_intermediate_00148 | INSRR, SOCS1, and KRAS share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a strong physical interaction between a suppressor of cytokine signaling protein and an insulin-like growth factor receptor detected via yeast two-hybrid assay. For which disease is this e... | prostate adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00148","source_qa_id":"medium_hidden_intermediate_07385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"INSRR, SOCS1, and KRAS share more than one reported protein partner. Evidence concerning one po... | |
medium_hidden_intermediate_00149 | TRIO and SNCA share more than one reported protein partner. Evidence concerning one possible intermediate entity describes the interaction between a guanine nucleotide exchange factor domain and an actin-crosslinking protein along with their cellular colocalization. For which disease is this entity reported as a biomar... | FG syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00149","source_qa_id":"medium_hidden_intermediate_07815","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"TRIO and SNCA share more than one reported protein partner. Evidence concerning one possible in... | |
medium_hidden_intermediate_00150 | MRPL53 and SP1 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes an association between a kinase and a transcription factor that is strengthened by a histone deacetylase inhibitor treatment. Which disease has a causal association with this entity? | kidney cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00150","source_qa_id":"medium_hidden_intermediate_09175","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"MRPL53 and SP1 share more than one reported protein partner. Evidence concerning one possible i... | |
medium_hidden_intermediate_00151 | West Nile virus and Primate bocaparvovirus 1 affect the expression of more than one gene in common; West Nile virus upregulates these genes, whereas Primate bocaparvovirus 1 upregulates them. Expression metadata for one possible intermediate entity show that it was upregulated in tracheobronchial epithelial cell with a... | asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00151","source_qa_id":"medium_hidden_intermediate_07291","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"West Nile virus and Primate bocaparvovirus 1 affect the expression of more than one gene in com... | |
medium_hidden_intermediate_00152 | More than one protein that interacts with one of ADCYAP1R1's protein partners also interacts with TRAF6. Evidence concerning one possible intermediate entity describes the specific requirement of an E3 ligase for kinase activation and its physical interaction with beta receptors via a homology domain. For which disease... | nervous system disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00152","source_qa_id":"medium_hidden_intermediate_08713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of ADCYAP1R1's protein partners also interacts wi... | |
medium_hidden_intermediate_00153 | NUBP2 and HSPA1A share more than one reported protein partner. Evidence concerning one possible intermediate entity describes the binding interaction between a chaperone co-chaperone and a heat shock protein in intact cells which increases upon short term chemical exposure. For which disease is this entity reported as ... | pituitary gigantism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00153","source_qa_id":"medium_hidden_intermediate_07485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"NUBP2 and HSPA1A share more than one reported protein partner. Evidence concerning one possible... | |
medium_hidden_intermediate_00154 | More than one protein that interacts with one of VSIG4's protein partners also interacts with STAT3. Evidence concerning one possible intermediate entity describes a physical association between a kinase and focal adhesion kinase mediated by a transcription factor. Which disease has a causal association with this entit... | brain neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00154","source_qa_id":"medium_hidden_intermediate_08334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of VSIG4's protein partners also interacts with S... | |
medium_hidden_intermediate_00155 | More than one protein that interacts with one of KPTN's protein partners also interacts with RBCK1. Evidence concerning one possible intermediate entity describes how a ring finger protein functions as an e3 ligase for oxidized iron regulatory protein suggesting oxidation is a recognition signal for ubiquitination. For... | alpha 1-antitrypsin deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00155","source_qa_id":"medium_hidden_intermediate_08604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"More than one protein that interacts with one of KPTN's protein partners also interacts with RB... | |
medium_hidden_intermediate_00156 | DGCR8, FUS, and HNRNPH1 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes functional analyses showing activity-critical amino acids localize to the C terminus, which specifically interacts with FUS and SMN in RNA processing. For which disease is this entity rep... | nasopharyngeal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00156","source_qa_id":"medium_hidden_intermediate_08663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"DGCR8, FUS, and HNRNPH1 share more than one reported protein partner. Evidence concerning one p... | |
medium_hidden_intermediate_00157 | MPG and HDAC1 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes a physical interaction between a key regulator of eukaryotic gene expression and an adaptor protein involved in cellular events. Which disease is linked to genomic alterations in this entity's gene... | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00157","source_qa_id":"medium_hidden_intermediate_09532","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"MPG and HDAC1 share more than one reported protein partner. Evidence concerning one possible in... | |
medium_hidden_intermediate_00158 | ZKSCAN8 and HDAC6 share more than one reported protein partner. Evidence concerning one possible intermediate entity describes two ribosomal proteins being detected within an immunocomplex of a histone deacetylase isolated from stressed cells. Which disease is linked to genomic alterations in this entity's gene? | malignant peripheral nerve sheath tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00158","source_qa_id":"medium_hidden_intermediate_07005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"node_context_joint","locator":"node_context","question":"ZKSCAN8 and HDAC6 share more than one reported protein partner. Evidence concerning one possibl... | |
medium_hidden_intermediate_00159 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in factors involved in megakaryocyte development and platelet production. One of these genes shows a log2 fold change of 9.327 and an adjusted p-value of 0.02494 in lung cells. Which disease is associated with this specif... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00159","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in factors involved in me... | |
medium_hidden_intermediate_00160 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the process 'E3 ubiquitin ligases ubiquitinate target proteins' was found to have a log2 fold change of approximately 1.676 and an adjusted p-value of 0.0001848. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF181 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00160","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the proces... | |
medium_hidden_intermediate_00162 | Measles morbillivirus upregulates a gene that is associated with carcinoma. Experimental data for this gene in study GSE131840 reports a log2 fold change of 2.340 and an adjusted p-value of 0.04544. Which disease is linked to this gene as a biomarker? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00162","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is associated with carcinoma. Experimental data for this gene in study GSE1318... | |
medium_hidden_intermediate_00163 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for psoriasis. This specific gene exhibits a log2 fold change of approximately 1.24 and an adjusted p-value of 0.003549. Which protein is encoded by this gene? | Tetraspanin-31 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00163","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_00164 | In a transcriptomic study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with CEP135. This gene exhibited a log2 fold change of approximately 1.90 and an adjusted p-value of approximately 0.008. What molecul... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a transcriptomic study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was... | |
medium_hidden_intermediate_00166 | Pegivirus C is reported to downregulate a gene that enables NAD+-protein mono-ADP-ribosyltransferase activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.67 and an adjusted p-value of approximately 0.028. Which cellular component is this spe... | nuclear envelope | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables NAD+-protein mono-ADP-ribosyltransferase activity. In a study of... | |
medium_hidden_intermediate_00168 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with STK4. One of these genes exhibits a log2 fold change of -1.943 and an adjusted p-value of 0.0007808 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with STK4. One of these ge... | |
medium_hidden_intermediate_00170 | Human immunodeficiency virus 1 upregulates a gene that is involved in mitochondrial calcium ion homeostasis. Evidence for this gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.0003889. Which protein is encoded by this gene? | Mitochondrial sodium/calcium exchanger protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in mitochondrial calcium ion homeostasis. Evidence for th... | |
medium_hidden_intermediate_00171 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with cerebral infarction. One of these genes exhibits a log2 fold change of approximately 1.31 and an adjusted p-value of approximately 0.0072 in cardiomyocyte cell lines (study GSE151879). Which disease is linked to t... | vascular dementia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00171","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with cerebral infarcti... | |
medium_hidden_intermediate_00172 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in phospholipid metabolism. One such gene exhibits a log2 fold change of -2.085 and an adjusted p-value of 0.0001357. Which protein is encoded by this specific gene? | Tumor necrosis factor alpha-induced protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00172","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_00173 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to GNAI3. Experimental data for one such gene reports a log2 fold change of 2.132 and an adjusted p-value of 8.266e-05. Which protein is encoded by this gene? | Adenylate cyclase type 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00173","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to GNAI3. Experimental data... | |
medium_hidden_intermediate_00175 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in organelle biogenesis and maintenance. Evidence for this gene reports a log2 fold change of -1.132 and an adjusted p-value of 0.03802. Which protein is encoded by this gene? | Molecular chaperone MKKS | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00175","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and particip... | |
medium_hidden_intermediate_00176 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with prostate cancer. One of these genes exhibits a log2 fold change of 1.971 and an adjusted p-value of 0.0005195 in a specific study. Which cell type is enriched for this specific gene? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00176","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with prostate cancer. ... | |
medium_hidden_intermediate_00178 | Two genes are upregulated by Human immunodeficiency virus 1 and enriched in peripheral blood mononuclear cells. One of these genes exhibits a log2 fold change of 2.453 and an adjusted p-value of 0.003557 in macrophages. Which protein is encoded by this specific gene? | Fatty acid hydroxylase domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00178","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enriched in peripheral blood mononuclear cells. One of these... | |
medium_hidden_intermediate_00179 | Human immunodeficiency virus 1 downregulates a gene that is involved in signal transduction. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of -4.665 and an adjusted p-value of 0.005976. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00179","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in signal transduction. Evidence for this gene in macro... | |
medium_hidden_intermediate_00181 | Zika virus upregulates a gene that enables DNA-binding transcription factor activity. In a specific study, this gene exhibited a log2 fold change of 1.248 and an adjusted p-value of 0.01208. Which protein is encoded by this gene? | Class E basic helix-loop-helix protein 40 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00181","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that enables DNA-binding transcription factor activity. In a specific study, this gene exhibit... | |
medium_hidden_intermediate_00182 | Measles morbillivirus upregulates a gene that interacts with CUL4A. One such gene exhibits a log2 fold change of 2.172 and an adjusted p-value of 0.02612. Which protein is encoded by this gene? | Tyrosine-protein kinase ABL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with CUL4A. One such gene exhibits a log2 fold change of 2.172 and a... | |
medium_hidden_intermediate_00184 | Zika virus downregulates a specific gene that is associated with leukemia. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.565 and an adjusted p-value of 0.03886. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00184","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with leukemia. Experimental data for this gene in glioma stem ce... | |
medium_hidden_intermediate_00185 | A gene is downregulated by Vaccinia virus and interacts with MYC. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.64 and an adjusted p-value of approximately 0.032. Which disease is associated with this gene as a biomarker? | Parkinson disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00185","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and interacts with MYC. Experimental data for this gene in a cervical adenocarcino... | |
medium_hidden_intermediate_00186 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RNF185. One of these genes was reported in a study on sclera cells with a log2 fold change of approximately 1.34 and an adjusted p-value of 0.0139. Which protein is encoded by this specific gene? | Transmembrane and ubiquitin-like domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00186","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RNF185. One of these ge... | |
medium_hidden_intermediate_00188 | Two genes are structurally linked in a pathway where Human immunodeficiency virus 1 downregulates the gene, and the gene is associated with lymphoma. One of these genes has a reported log2 fold change of -1.331 and an adjusted p-value of 0.01497 in macrophages (study GSE108897). Which protein is encoded by the gene mat... | Metallothionein-1E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00188","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway where Human immunodeficiency virus 1 downregulates the gene, and the gene is ... | |
medium_hidden_intermediate_00189 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. This gene exhibits a log2 fold change of approximately 1.026 and an adjusted p-value of approximately 2.2... | ZBTB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00189","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_00191 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that are localized to the Golgi apparatus. One such gene exhibited a log2 fold change of 1.203 and an adjusted p-value of 1.09e-05. Which protein is encoded by this specific gene? | Protein kish-A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_00193 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Pyruvate metabolism. Evidence for this gene reports a log2 fold change of approximately 1.25 and an adjusted p-value of approximately 0.00031. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00193","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Pyruvate metabolism. Evid... | |
medium_hidden_intermediate_00194 | Two genes are structurally linked to PPP1R15A via an 'interacts with' relationship and subsequently linked to the function 'protein binding' via an 'enables' relationship. One of these genes is supported by evidence stating: 'We report here that human cochaperone protein BAG-1 interacts with GADD34 in vitro and in SW48... | BAG family molecular chaperone regulator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to PPP1R15A via an 'interacts with' relationship and subsequently linked to the function '... | |
medium_hidden_intermediate_00195 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with skin cancer. One of these genes exhibits a log2 fold change of 3.964 and an adjusted p-value of 0.008454 in a specific study. Which protein is encoded by this gene? | Placenta growth factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00195","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with skin cancer. One ... | |
medium_hidden_intermediate_00196 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the metabolism of lipids. Experimental evidence for this gene reports a log2 fold change of 1.048 and an adjusted p-value of 0.04681. Which protein is encoded by this gene? | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00196","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the metabolism of lipids. Experimental evidence for th... | |
medium_hidden_intermediate_00199 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a gene involved in the negative regulation of double-strand break repair via homologous recombination. One such gene exhibits a log2 fold change of 7.101 and an adjusted p-value of 0.001353. Which protein is encoded b... | RPA-related protein RADX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00199","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a gene involved in th... | |
medium_hidden_intermediate_00200 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to thyroid tumor via biomarker association. One of these genes exhibits a log2 fold change of 1.026 and an adjusted p-value of 0.01433 in a specific study context. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00200","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to thyroid tumor via biom... | |
medium_hidden_intermediate_00201 | A specific gene serves as a marker for Memory CD8+ T cells and is also enriched in Gamma delta (γδ) T cells. Evidence for this gene includes a mean expression of 599.78 TPM, a z-score of 1.79, and a fold enrichment of 10.16. Which disease is associated with this gene through genomic alterations? | Epstein-Barr virus infection | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00201","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for Memory CD8+ T cells and is also enriched in Gamma delta (γδ) T cells. Evidence for th... | |
medium_hidden_intermediate_00204 | Cardiovirus A is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibited a log2 fold change of approximately -1.18 and an adjusted p-value of 0.01127. Which protein is encoded by this specific gene? | Homeodomain-interacting protein kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study of cervic... | |
medium_hidden_intermediate_00206 | Two genes are each upregulated by Hepacivirus C and associated with prostate cancer. One of these genes exhibits a log2 fold change of approximately 1.08 and an adjusted p-value of 0.0003355 in hepatocytes (study GSE132606). Which protein interacts with this specific gene? | MRM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00206","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Hepacivirus C and associated with prostate cancer. One of these genes exhibits a log2 fold... | |
medium_hidden_intermediate_00207 | Pegivirus C downregulates multiple genes that participate in O-linked glycosylation. One such gene exhibits a log2 fold change of -1.592 and an adjusted p-value of 0.01014 in peripheral blood mononuclear cells (study GSE131504). Which molecular function is enabled by this specific gene? | peptide-O-fucosyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00207","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates multiple genes that participate in O-linked glycosylation. One such gene exhibits a log2 fold chan... | |
medium_hidden_intermediate_00210 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in the process 'TP53 Regulates Metabolic Genes'. Evidence for this gene reports a log2 fold change of 1.155 and an adjusted p-value of 0.01922. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 6A1, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00210","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_00211 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. Evidence for this gene reports a log2 fold change of -1.929 and an adjusted p-value of 0.01539. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase DTX4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the proteasome-mediated ubiqu... | |
medium_hidden_intermediate_00212 | In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and associated with protein kinase activity showed a log2 fold change of 3.073 and an adjusted p-value of 0.02477. Which gene interacts with this specific entity? | MAPK8IP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00212","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and associated with protein kina... | |
medium_hidden_intermediate_00214 | In a study of hepatocytes (GSE135619), Orthohepevirus A infection leads to the upregulation of specific genes located in the cytoplasm. One such gene exhibits a log2 fold change of approximately 1.129 and an adjusted p-value of 0.02809. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase ZNRF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of hepatocytes (GSE135619), Orthohepevirus A infection leads to the upregulation of specific genes located in the... | |
medium_hidden_intermediate_00215 | Zika virus downregulates a gene that subsequently interacts with PLK1. Experimental data for one such gene reports a log2 fold change of -2.630 and an adjusted p-value of 0.01163. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that subsequently interacts with PLK1. Experimental data for one such gene reports a log2 fo... | |
medium_hidden_intermediate_00216 | Zika virus downregulates a gene that interacts with PPP2R2D. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.789 and an adjusted p-value of 0.01708. Which protein is encoded by this gene? | ATP-citrate synthase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with PPP2R2D. In a study of glioma stem cells (GSE114907), one such gene exhi... | |
medium_hidden_intermediate_00217 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with RAB11A. One of these genes shows a log2 fold change of 1.322 and an adjusted p-value of 0.0001676 in a specific study. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00217","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with RAB11A. One of these genes shows a log2 fold c... |
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