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medium_divergent_branch_06322 | UBE2E3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using in vitro E3 assays and yeast two-hybrid screens, we found that Ube2d, Ube2e families, Ube2n/2v1, and Ube2w catalyze autoubiquitination of the [protein] and Ube2d2, Ube2e1, and Ube 2n/2v1 catalyze [protein]-mediated substra... | E3 ubiquitin-protein ligase CBL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06322","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2E3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using in vitro E3 assays and yeast two-hybrid screens, we... | |
medium_divergent_branch_06323 | Alpha-fetoprotein (AFP) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'A direct protein-protein interaction assay showed that AFP physically interacts with the target molecule, abolishes its binding to caspase and rescues caspase 3 from inhibition.' Which protein, encoded ... | E3 ubiquitin-protein ligase XIAP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06323","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Alpha-fetoprotein (AFP) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'A direct protein-protein intera... | |
medium_divergent_branch_06324 | CTPS1 is associated with multiple biological processes. One specific association is supported by evidence describing a loss-of-function homozygous mutation (rs145092287) in humans that causes a life-threatening immunodeficiency, characterized by an impaired capacity of activated T and B cells to proliferate in response... | B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTPS1 is associated with multiple biological processes. One specific association is supported by evidence describing a loss-of-function homozygous mu... | |
medium_divergent_branch_06326 | VEGFD is known to interact with multiple receptor genes. One specific interaction is characterized by the finding that mouse VEGF-D fails to bind mouse VEGFR-2 but binds and cross-links a specific receptor, as demonstrated by biosensor analysis and bioassays. Which protein is encoded by the gene corresponding to the re... | Vascular endothelial growth factor receptor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06326","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VEGFD is known to interact with multiple receptor genes. One specific interaction is characterized by the finding that mouse VEGF-D fails to bind mou... | |
medium_divergent_branch_06327 | DIO2 interacts with multiple proteins. One interaction is described by the following evidence: 'The D2 dimer associates with the Hedgehog-inducible ubiquitin ligase WSB-1, the ubiquitin conjugase UBC-7, and VDU-1, a D2-specific deubiquitinase.' Based on this specific evidence, which cellular component is the interactin... | Lewy body | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06327","source_qa_id":"medium_divergent_branch_07074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DIO2 interacts with multiple proteins. One interaction is described by the following evidence: 'T... | |
medium_divergent_branch_06328 | LRP12 is associated with multiple biological processes. One specific association is supported by evidence that in vitro knockdown of LRP12 in primary neurons results in impaired neuronal arborization. Which biological process is a parent term (via the 'is a' relationship) of the process linked to LRP12 by this specific... | plasma membrane bounded cell projection organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06328","source_qa_id":"medium_divergent_branch_03319","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LRP12 is associated with multiple biological processes. One specific association is supported by ... | |
medium_divergent_branch_06329 | CD33 is associated with multiple molecular functions via the 'enables' relationship. One of these functions is supported by evidence stating that engagement of the entity led to inhibition in some experiments. Which molecular function, connected to this specific function via the 'is_a' relationship, is the correct targ... | molecular transducer activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06329","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD33 is associated with multiple molecular functions via the 'enables' relationship. One of these functions is supported by evidence stating that eng... | |
medium_divergent_branch_06331 | FGFR1 interacts with multiple proteins. One specific interaction is described as a direct binding between the fibronectin type III (FN3) modules I-V of a particular protein and the immunoglobulin (Ig) modules II and III of FGFR1, as demonstrated by surface plasmon resonance analysis. Which disease is associated with ge... | MASA syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06331","source_qa_id":"medium_divergent_branch_03599","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FGFR1 interacts with multiple proteins. One specific interaction is described as a direct binding... | |
medium_divergent_branch_06332 | GLIPR2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'The cell migration assay demonstrated that the transfection of HK-2 with GLIPR-2 promoted cell migration following an EMT.' Which biological process is positively regul... | epithelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06332","source_qa_id":"medium_divergent_branch_06978","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GLIPR2 is associated with multiple biological processes via the 'involved in' relationship. One s... | |
medium_divergent_branch_06333 | POU1F1 interacts with multiple genes. One interaction is supported by evidence stating: 'Glutathione-S-transferase interaction studies showed that MED220 or GATA-2 each bound the homeodomain of Pit-1, whereas MED220 interacted independently with each zinc finger of GATA-2 but not with either terminus.' Which disease is... | streptococcal pneumonia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06333","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POU1F1 interacts with multiple genes. One interaction is supported by evidence stating: 'Glutathione-S-transferase interaction studies showed that ME... | |
medium_divergent_branch_06334 | The gene FLNB is known to interact with multiple partners. One specific interaction is supported by the following evidence: 'We have confirmed the interaction of beta-filamin and the protein encoded by the interacting partner gene in platelet and HUVEC lysates.' Which protein is encoded by the gene that corresponds to ... | Platelet glycoprotein Ib alpha chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06334","source_qa_id":"medium_divergent_branch_00427","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene FLNB is known to interact with multiple partners. One specific interaction is supported ... | |
medium_divergent_branch_06335 | DDR2 is associated with multiple biological processes. One specific association is supported by evidence showing that knockdown of DDR2 suppressed osteogenic marker gene expression and matrix mineralization during induced osteogenesis. Which biological process, connected to DDR2 via an 'involved in' relationship, is su... | bone mineralization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06335","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDR2 is associated with multiple biological processes. One specific association is supported by evidence showing that knockdown of DDR2 suppressed os... | |
medium_divergent_branch_06336 | PLA2G3 is associated with multiple biological processes. One association is supported by evidence that PLA2G3-modified LDL, similar to LDL treated with PLA2G5 or PLA2G10, facilitates the formation of foam cells from macrophages in ex vivo experiments. Which biological process is positively regulated by the process link... | macrophage derived foam cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLA2G3 is associated with multiple biological processes. One association is supported by evidence that PLA2G3-modified LDL, similar to LDL treated wi... | |
medium_divergent_branch_06337 | ZW10 interacts with multiple proteins. One interaction involves a protein that resides in a complex with Rod and itself in mitotic human cells, whereas another ZW10 partner is part of a separate complex of structural kinetochore components including Mis12 and Ndc80-Hec1. Which protein, connected to ZW10 through a bindi... | Protein zwilch homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06337","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZW10 interacts with multiple proteins. One interaction involves a protein that resides in a complex with Rod and itself in mitotic human cells, where... | |
medium_divergent_branch_06338 | FN1 interacts with multiple proteins. One interaction partner is described by evidence stating that a specific protein binds in solid-phase assays to collagens IV, V, and VI, fibronectin, and nidogen, but not to fibrillar collagens I and III or other basement membrane proteins. Which protein is encoded by the gene corr... | Galectin-3-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06338","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FN1 interacts with multiple proteins. One interaction partner is described by evidence stating that a specific protein binds in solid-phase assays to... | |
medium_divergent_branch_06339 | KSR1 interacts with multiple proteins. One specific interaction involves a partner that constitutively associates with mammalian KSR1 and phosphorylates serine 392, thereby conferring 14-3-3 binding and cytoplasmic sequestration of KSR1 in unstimulated cells. Which protein, connected to KSR1 via this binding interactio... | MAP/microtubule affinity-regulating kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06339","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KSR1 interacts with multiple proteins. One specific interaction involves a partner that constitutively associates with mammalian KSR1 and phosphoryla... | |
medium_divergent_branch_06340 | TFR2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results are consistent with a scenario in which TFR2 plays a prominent and HFE a contributory role in the hepcidin response to a dose of oral iron.' Which broader biological process is a parent of the specific ... | response to metal ion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06340","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TFR2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results are consistent with a scenario ... | |
medium_divergent_branch_06341 | DNPEP is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We show that [interacting protein] interacts with and phosphorylates DNPEP at serine 119.' Based on this evidence, which protein is the one interacting with DNPEP, and what is the protein product encoded by th... | Serine/threonine-protein kinase PAK 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06341","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNPEP is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We show that [interacting protein] int... | |
medium_divergent_branch_06342 | AMFR interacts with multiple proteins. One interaction is supported by evidence stating: 'The polyubiquitylation of the interaction partner in vitro depends on a physical interaction between the CUE domain of gp78 and the ubiquitin-like (UBL) domain of the interaction partner, which is essential for the interaction par... | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06342","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMFR interacts with multiple proteins. One interaction is supported by evidence stating: 'The polyubiquitylation of the interaction partner in vitro ... | |
medium_divergent_branch_06343 | BAZ1B interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that NM1 binds SNF2h with enhanced affinity upon impairment of the actin-binding function.' Which protein, connected to BAZ1B via this specific interaction context, is encoded by the gene in question? | Unconventional myosin-Ic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06343","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAZ1B interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that NM1 binds SNF2h with enhanced affinity... | |
medium_divergent_branch_06344 | SUMO3 interacts with multiple proteins. One of these interactions is characterized by GST pull-down and immunoprecipitation assays showing that the interacting protein binds directly and noncovalently to SUMO2/3, but not to SUMO1, and that its FHA domain is required for this binding. Which protein is this? | E3 ubiquitin-protein ligase RNF8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06344","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUMO3 interacts with multiple proteins. One of these interactions is characterized by GST pull-down and immunoprecipitation assays showing that the i... | |
medium_divergent_branch_06345 | TRIM65 interacts with multiple proteins. One interaction is supported by evidence stating: 'Detailed analysis indicates that TRIM65 interacts and colocalizes with trinucleotide repeat containing six proteins in processing body-like structures.' Which protein, encoded by the gene identified in this evidence, is the down... | Trinucleotide repeat-containing gene 6A protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06345","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM65 interacts with multiple proteins. One interaction is supported by evidence stating: 'Detailed analysis indicates that TRIM65 interacts and col... | |
medium_divergent_branch_06346 | The VHL gene interacts with multiple partners. One partner is described by evidence stating that a specific gene encodes a 64-kDa protein that interacts strongly with the VHL protein and is most highly expressed in the kidney. Which protein is encoded by the gene connected to VHL through this specific interaction evide... | Protein Jade-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06346","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The VHL gene interacts with multiple partners. One partner is described by evidence stating that a specific gene encodes a 64-kDa protein that intera... | |
medium_divergent_branch_06348 | GDI1 interacts with multiple genes. One of these interactions is supported by evidence describing a mutant of the human G-protein corresponding to the gene CDC42 (R66E) that fails to form a detectable complex with the GDP-dissociation inhibitor RhoGDI in cell-free systems or in intact cells. Which cell type is the gene... | non-classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06348","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GDI1 interacts with multiple genes. One of these interactions is supported by evidence describing a mutant of the human G-protein corresponding to th... | |
medium_divergent_branch_06349 | BTLA is associated with multiple biological processes via the 'involved in' relationship. One piece of evidence describes BTLA as an immune-regulatory receptor, similar to CTLA-4 and PD-1, primarily expressed on B cells, T cells, and other mature lymphocytes. Which of these associated biological processes is connected ... | T cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTLA is associated with multiple biological processes via the 'involved in' relationship. One piece of evidence describes BTLA as an immune-regulator... | |
medium_divergent_branch_06351 | PLA2R1 is associated with multiple biological processes. One specific association is supported by evidence that sPLA2 IB-induced podocyte PLA2R upregulation was associated with increased ERK1/2 and cPLA2α phosphorylation and displayed enhanced apoptosis. Which biological process is positively regulated by the process l... | podocyte apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLA2R1 is associated with multiple biological processes. One specific association is supported by evidence that sPLA2 IB-induced podocyte PLA2R upreg... | |
medium_divergent_branch_06352 | FANCC interacts with multiple proteins. One interaction is supported by evidence showing that glutathione S-transferase fusion proteins encoding normal FANCC, but not a mutant FANCC bearing an inactivating point mutation (L554P), bound to the interacting partner in lysates of IFN-gamma-stimulated B cells and IFN-, gran... | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06352","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCC interacts with multiple proteins. One interaction is supported by evidence showing that glutathione S-transferase fusion proteins encoding norm... | |
medium_divergent_branch_06353 | The gene ORC2 is known to interact with multiple protein partners. One specific interaction is characterized by the finding that the C-terminal region of ORC2 interacts directly with the N-terminal region of its binding partner. Which protein is encoded by the gene corresponding to this specific binding partner? | Origin recognition complex subunit 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06353","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ORC2 is known to interact with multiple protein partners. One specific interaction is characterized by the finding that the C-terminal regio... | |
medium_divergent_branch_06354 | PCBP2 is reported to interact with multiple genes. One specific interaction evidence states that PCBP2 directly interacted with YAP via a WB motif-WW domain interaction, whereas it indirectly interacted with the target gene via the aid of YAP. Which gene, linked to PCBP2 by the relation 'interacts with', is the subject... | YY1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06354","source_qa_id":"medium_divergent_branch_02205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PCBP2 is reported to interact with multiple genes. One specific interaction evidence states that ... | |
medium_divergent_branch_06355 | TRAF3IP2 interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'The mutation, located in the SEFIR domain, abolished the homotypic interaction of ACT1 with IL-17 receptors, with no effect on homodimerization.' Which protein product is encoded by the gene corresponding to this s... | Interleukin-17 receptor A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06355","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF3IP2 interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'The mutation, located in the SEFIR domain, ... | |
medium_divergent_branch_06356 | The gene THRB interacts with multiple proteins. One interaction is supported by evidence stating that a specific coactivator protein binds to thyroid hormone receptor (TR) and other nuclear receptors in a ligand-dependent manner, enhancing ligand-induced transcriptional activity. Which protein, connected to THRB via th... | Nuclear receptor coactivator 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06356","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene THRB interacts with multiple proteins. One interaction is supported by evidence stating that a specific coactivator protein binds to thyroid... | |
medium_divergent_branch_06357 | AKAP11 interacts with multiple genes. One interaction is supported by evidence showing that Anti-hAKAP220 antisera coimmunoprecipitated both type I and type II regulatory subunits of PKA in human testis lysates, indicating that hAKAP220 interacts with both classes of R subunits. Which protein is encoded by the gene con... | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06357","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP11 interacts with multiple genes. One interaction is supported by evidence showing that Anti-hAKAP220 antisera coimmunoprecipitated both type I a... | |
medium_divergent_branch_06358 | ACVR1B interacts with multiple genes via binding interactions. One specific interaction is supported by evidence stating that biotinylated inhibin A, but not activin A, bound ALK4. Which protein is encoded by the gene involved in this specific interaction? | Inhibin beta A chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06358","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACVR1B interacts with multiple genes via binding interactions. One specific interaction is supported by evidence stating that biotinylated inhibin A,... | |
medium_divergent_branch_06359 | MEGF10 is associated with multiple biological processes. One specific association is supported by evidence stating that MEGF10 is highly expressed in activated satellite cells and regulates their proliferation, differentiation, and fusion into multinucleated myofibers. Which broader biological process is the parent of ... | skeletal muscle cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06359","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEGF10 is associated with multiple biological processes. One specific association is supported by evidence stating that MEGF10 is highly expressed in... | |
medium_divergent_branch_06361 | The biological process 'regulation of renal water transport' is defined as any process that modulates the frequency, rate, or extent of renal water transport. This process is a subtype of a broader biological process. Which broader biological process is 'regulation of renal water transport' a subtype of? | regulation of localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06361","source_qa_id":"medium_divergent_branch_03668","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of renal water transport' is defined as any process that modul... | |
medium_divergent_branch_06362 | BIN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identified the shared gene as a novel binding partner of BIN1, both in vitro and endogenously in skeletal muscle.' Which protein, encoded by the gene interacting with BIN1 in this specific context, is the subject of this ... | Myotubularin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06362","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identified the shared gene as a novel binding part... | |
medium_divergent_branch_06363 | The gene GRIN1 interacts with multiple other genes. One specific interaction is supported by evidence stating that Spectrin interacts selectively in vitro with the C-terminal cytoplasmic domains of the NR1a, NR2A, and NR2B subunits of the NMDA receptor, but not with the AMPA receptor subunit GluR1. Which protein is enc... | Spectrin alpha chain, non-erythrocytic 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06363","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GRIN1 interacts with multiple other genes. One specific interaction is supported by evidence stating that Spectrin interacts selectively in ... | |
medium_divergent_branch_06365 | The femur cartilage element is a subtype of two distinct anatomical categories. One of these categories is defined as an entity composed primarily of cartilage tissue. Which anatomical structure does this specific category develop from? | pre-cartilage condensation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06365","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The femur cartilage element is a subtype of two distinct anatomical categories. One of these categories is defined as an entity composed primarily of... | |
medium_divergent_branch_06366 | RHOQ interacts with multiple proteins. One of these interaction partners is implicated in a mechanism where Tc10, RhoT, and Cdc42 bind to the N-terminal CRIB-motif-containing portion of this partner, activating it to induce Arp2/3-complex-mediated actin polymerization. Which protein is encoded by the gene corresponding... | Actin nucleation-promoting factor WASL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06366","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RHOQ interacts with multiple proteins. One of these interaction partners is implicated in a mechanism where Tc10, RhoT, and Cdc42 bind to the N-termi... | |
medium_divergent_branch_06367 | GSTM3 interacts with multiple genes. One of these interaction partners functions as an exchange factor that integrates Kelch-like ECH-associated protein 1 (KEAP1) into Cul3-RING ubiquitin ligases (CRL3). In a feedback loop, this partner binds to disrupt the NRF2/KEAP1 complex, thereby preventing NRF2 ubiquitination and... | prostate carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06367","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSTM3 interacts with multiple genes. One of these interaction partners functions as an exchange factor that integrates Kelch-like ECH-associated prot... | |
medium_divergent_branch_06368 | DIS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein, connected to DIS3 via this interaction, is encoded by the gene in question? | Exosome complex component RRP45 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06368","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DIS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate the association of two different Dis3p... | |
medium_divergent_branch_06369 | ERCC6 interacts with multiple genes. One of these interacting partners is described in the following evidence: 'Here we report that a tumor suppressor protein can bind to several transcription factor IIH-associated factors, including transcription-repair factors, XPD (Rad3) and XPB, as well as CSB involved in strand-sp... | inflammatory disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC6 interacts with multiple genes. One of these interacting partners is described in the following evidence: 'Here we report that a tumor suppresso... | |
medium_divergent_branch_06373 | Glomerular filtration is associated with multiple anatomical structures. One of these structures is described as 'The capillary loops of the kidney that normally function as a filtration unit.' Which anatomical structure, from which the identified anatomy develops, is the target of the 'develops from' relationship? | metanephric mesenchyme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06373","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Glomerular filtration is associated with multiple anatomical structures. One of these structures is described as 'The capillary loops of the kidney t... | |
medium_divergent_branch_06374 | The gene BSG (CD147) forms physical complexes with multiple partners. One specific interaction is supported by evidence stating: 'Here we use co-immunoprecipitation and chemical cross-linking to demonstrate that CD147 specifically interacts with a member of the proton-linked monocarboxylate (lactate) transporter family... | SNX27 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06374","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BSG (CD147) forms physical complexes with multiple partners. One specific interaction is supported by evidence stating: 'Here we use co-immu... | |
medium_divergent_branch_06375 | The gene IL23A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'These data support the role of IL-23 in inflammation through stimulating IL-17 production by T lymphocytes.' Identify the biological process that is positively ... | T-helper 17 type immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL23A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence... | |
medium_divergent_branch_06377 | MYH9 interacts with multiple genes. One specific interaction is supported by mechanistic experiments showing that the binding of MYH9 to a partner protein, which acts as a potential promoter of tumor proliferation, inhibits the ubiquitination and degradation of that partner by recruiting USP14. Which disease is associa... | depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06377","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYH9 interacts with multiple genes. One specific interaction is supported by mechanistic experiments showing that the binding of MYH9 to a partner pr... | |
medium_divergent_branch_06378 | The gene KCNMA1 interacts with multiple other genes. One specific interaction is supported by evidence showing that MaxiK and TP physically associate, display high proximity, and exhibit Förster resonance energy transfer (FRET) between fluorescently labeled forms, indicating a direct interaction. Which protein is encod... | Thromboxane A2 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06378","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KCNMA1 interacts with multiple other genes. One specific interaction is supported by evidence showing that MaxiK and TP physically associate... | |
medium_divergent_branch_06379 | The gene TSC22D3 (encoding GILZ) interacts with multiple proteins. One interaction is characterized by the following evidence: 'In particular, GILZ inhibits NF-kappaB nuclear translocation and DNA binding due to a direct protein-to-protein interaction of GILZ with the NF-kappaB subunits.' Which protein is encoded by th... | Nuclear factor NF-kappa-B p100 subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06379","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TSC22D3 (encoding GILZ) interacts with multiple proteins. One interaction is characterized by the following evidence: 'In particular, GILZ i... | |
medium_divergent_branch_06380 | GMEB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'These properties of the GME are intimately related to the binding of a heteromeric complex of two proteins (GMEB-1 and -2).' Which protein, connected to GMEB1 via this specific interaction, is encoded by the gene in question? | Glucocorticoid modulatory element-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06380","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GMEB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'These properties of the GME are intimately related to the ... | |
medium_divergent_branch_06381 | The microRNA mmu-miR-125b-5p regulates multiple cell types. One specific regulatory connection is supported by evidence stating: 'Thus, we propose miR-125b-2 as a positive regulator of megakaryopoiesis and an oncomiR involved in the pathogenesis of trisomy 21-associated megakaryoblastic leukemia.' Identify the cell typ... | myeloid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The microRNA mmu-miR-125b-5p regulates multiple cell types. One specific regulatory connection is supported by evidence stating: 'Thus, we propose mi... | |
medium_divergent_branch_06382 | The intervertebral disk of the thoracic vertebra is a type of anatomy that connects to a broader anatomical structure via a 'part of' relationship. Evidence for this connection describes the entity as an intervertebral disk that is part of a thoracic region of the vertebral column, connecting at least one thoracic vert... | thoracic segment of trunk | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The intervertebral disk of the thoracic vertebra is a type of anatomy that connects to a broader anatomical structure via a 'part of' relationship. E... | |
medium_divergent_branch_06383 | ABCA3 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'The ATP-binding cassette transporter ABCA3 is expressed predominantly at the limiting membrane of the lamellar bodies in lung alveolar type II cells.' Based on this specif... | lamellar body membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06383","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA3 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: '... | |
medium_divergent_branch_06384 | Cholangiocytes are epithelial cells that are part of a specific anatomical structure. Evidence indicates that these cells contribute to bile secretion via the net release of bicarbonate and water. They appear as cuboidal epithelium in small interlobular structures of this type, but become columnar and mucus-secreting i... | biliary tree | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06384","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cholangiocytes are epithelial cells that are part of a specific anatomical structure. Evidence indicates that these cells contribute to bile secretio... | |
medium_divergent_branch_06385 | The protein LETM1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Our results demonstrate that bi-allelic LETM1 variants are associated with defective mitochondrial K+ efflux.' Identify the biological process described by this evidence, and then determine th... | potassium ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein LETM1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Our results demonstra... | |
medium_divergent_branch_06386 | ATF3 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Furthermore, ATF3 formed an endogenous complex with this protein in CD4(+) T cells induced to Th1.' What is the name of the protein encoded by the gene corresponding to this interaction partner? | Transcription factor Jun | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06386","source_qa_id":"medium_divergent_branch_00178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ATF3 interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_06387 | Pyrimethamine interacts with multiple drugs. One specific interaction is supported by evidence stating: 'The most commonly used therapeutic regimen, and probably the most effective, is the combination of pyrimethamine with this interaction partner and folinic acid.' Which disease is this interaction partner indicated f... | rheumatic fever | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06387","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pyrimethamine interacts with multiple drugs. One specific interaction is supported by evidence stating: 'The most commonly used therapeutic regimen, ... | |
medium_divergent_branch_06388 | APPL1 interacts with multiple genes. One of these interaction partners is known to interact with adiponectin receptors in mammalian cells, an interaction that is stimulated by adiponectin. Which disease is associated with this specific interaction partner via a biomarker relationship? | lipodystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06388","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APPL1 interacts with multiple genes. One of these interaction partners is known to interact with adiponectin receptors in mammalian cells, an interac... | |
medium_divergent_branch_06389 | hsa-miR-299-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Among the upregulated lineage-enriched microRNAs, hsa-miR-299-5p emerged as having a role in controlling CD34+ progenitor fate, grown in multilineage culture conditions.' Which cell type, connected to the regulat... | angioblastic mesenchymal cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06389","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-299-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Among the upregulated lineage-enriched mi... | |
medium_divergent_branch_06390 | FBXL7 interacts with multiple proteins. Evidence for one of these interactions indicates that an FQ motif within FBXL7 serves as a molecular recognition site for the binding partner. Which protein, encoded by the gene connected to FBXL7 via this specific interaction, is the target of this recognition? | F-box/LRR-repeat protein 18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06390","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXL7 interacts with multiple proteins. Evidence for one of these interactions indicates that an FQ motif within FBXL7 serves as a molecular recognit... | |
medium_divergent_branch_06392 | LGALS9 is associated with multiple biological processes. One association is supported by evidence that Galectin-9 induces intracellular calcium flux, aggregation, and death of T(H)1 cells in a Tim-3-dependent manner in vitro, and that in vivo administration of galectin-9 leads to the selective loss of interferon-gamma-... | T-helper 1 type immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06392","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGALS9 is associated with multiple biological processes. One association is supported by evidence that Galectin-9 induces intracellular calcium flux,... | |
medium_divergent_branch_06393 | Metallothionein-3 (MT3) interacts with multiple proteins. One specific interaction is characterized by a dissociation constant (Kd) of 373.7 +/- 60.2 nM. Which protein, encoded by the gene connected to MT3 via this specific high-affinity interaction, is the subject of this measurement? | Transthyretin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06393","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Metallothionein-3 (MT3) interacts with multiple proteins. One specific interaction is characterized by a dissociation constant (Kd) of 373.7 +/- 60.2... | |
medium_divergent_branch_06394 | ANXA3 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we report that annexin A3 induces migration and tube formation of human umbilical vein endothelial cells.' Which biological process, connected to the process supported by this evidence via a 'positively regul... | endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANXA3 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we report that annexin A3 induces mig... | |
medium_divergent_branch_06395 | SH3KBP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A direct interaction of synaptojanin 1 and this gene with CIN85 SH3 domains was confirmed by Far Western blotting.' Which disease is associated with this gene via a biomarker relationship? | malignant pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06395","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3KBP1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'A direct interaction of synaptojanin 1 and this g... | |
medium_divergent_branch_06396 | The protein EIF2S2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by the following evidence: 'These findings suggest that subunits of mammalian eIF2 interact with each other and the beta-subunit plays a critical role both in the regulation and ... | regulation of translation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06396","source_qa_id":"medium_divergent_branch_01125","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein EIF2S2 is associated with multiple biological processes via the 'involved in' relatio... | |
medium_divergent_branch_06397 | Eosinophil differentiation is enabled by more than one cell type. One of these cell types is defined as a granulocytopoietic cell that expresses transcription factors PU.1, CCAAT/enhancer-binding protein alpha, and an erythroid transcription factor. This cell type lacks plasma membrane expression of CD19, CD4, integrin... | granulocyte monocyte progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Eosinophil differentiation is enabled by more than one cell type. One of these cell types is defined as a granulocytopoietic cell that expresses tran... | |
medium_divergent_branch_06399 | Prasugrel interacts with multiple drugs. One of these interacting drugs is discussed in the context of recent data suggesting that administering a thienopyridine plus warfarin (or possibly a NOAC), while skipping aspirin, may be an alternative to avoid severe bleeding and maintain antithrombotic efficacy. Which disease... | pulmonary embolism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06399","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Prasugrel interacts with multiple drugs. One of these interacting drugs is discussed in the context of recent data suggesting that administering a th... | |
medium_divergent_branch_06400 | FANCG interacts with multiple proteins. One interaction is supported by evidence stating that 'Protein interaction studies indicated that FANCA and FANCG bind directly to mu-calpain.' Which protein, encoded by the gene interacting with FANCG in this specific context, is the subject of this evidence? | Calpain-1 catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCG interacts with multiple proteins. One interaction is supported by evidence stating that 'Protein interaction studies indicated that FANCA and F... | |
medium_divergent_branch_06401 | MARCH5 interacts with multiple genes. One of these interaction partners is characterized by evidence showing that it binds to the transmembrane region of MARCH5 and targets it to peroxisomes. Which disease is associated with this specific interaction partner via a biomarker relationship? | Zellweger spectrum disorders | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06401","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH5 interacts with multiple genes. One of these interaction partners is characterized by evidence showing that it binds to the transmembrane regio... | |
medium_divergent_branch_06403 | SPDL1 interacts with multiple proteins. Evidence for one specific interaction states: 'Our data show that Spindly and the interaction partner are part of the same complex and that their interaction specifically depends on the catalytic activity of the interaction partner.' What is the full protein name encoded by the g... | Ubiquitin carboxyl-terminal hydrolase 45 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06403","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPDL1 interacts with multiple proteins. Evidence for one specific interaction states: 'Our data show that Spindly and the interaction partner are par... | |
medium_divergent_branch_06404 | MAP4K5 interacts with multiple genes. One of these interaction partners is an adaptor protein that, along with CrkL, was shown to associate with GCKR in a specific study. Which disease is associated with this specific interaction partner? | autism spectrum disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06404","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP4K5 interacts with multiple genes. One of these interaction partners is an adaptor protein that, along with CrkL, was shown to associate with GCKR... | |
medium_divergent_branch_06405 | UNC5B interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that UNC5H2/B recruits a protein complex that includes PR65β and DAPk and retains PP2A activity.' Which protein, connected to UNC5B via this specific interaction, is encoded by the gene in question? | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06405","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UNC5B interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that UNC5H2/B recruits a protein complex that incl... | |
medium_divergent_branch_06406 | PRKCZ interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate that the aPKCs interact in an EGF-inducible manner with [Protein X] and that this interaction is required and sufficient for the activation of [Protein X] in response to EGF.' Which protein, encoded by the gen... | Dual specificity mitogen-activated protein kinase kinase 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCZ interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate that the aPKCs interact in an EGF-indu... | |
medium_divergent_branch_06407 | Leukocytes are components of multiple anatomical structures. One such structure is described as 'An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.' Which anatomical entity, connected to the leukocyte via a 'part of' relationship, is described by this evi... | non-connected functional system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Leukocytes are components of multiple anatomical structures. One such structure is described as 'An achromatic cell of the myeloid or lymphoid lineag... | |
medium_divergent_branch_06408 | Cisatracurium interacts with multiple drugs. Evidence for one of these interactions states that the interacting agent significantly prolonged all neuromuscular blocking (NMB) recovery features without altering the speed of onset of cisatracurium. Which disease is the drug exhibiting this specific interaction profile in... | eclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06408","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cisatracurium interacts with multiple drugs. Evidence for one of these interactions states that the interacting agent significantly prolonged all neu... | |
medium_divergent_branch_06410 | VPS13B is associated with multiple biological processes. One specific association is supported by evidence showing that invalidation of VPS13B leads to accelerated differentiation into fat cells, confirmed by earlier and increased expression of specific adipogenic genes. Which anatomical structure is the result of the ... | adipose tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06410","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS13B is associated with multiple biological processes. One specific association is supported by evidence showing that invalidation of VPS13B leads ... | |
medium_divergent_branch_06411 | USP18 interacts with multiple proteins. One specific interaction is described by the following evidence: 'We found that this protein recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal binding site.' Which protein, linked to USP18 by this interaction, is encoded by the gene in ... | Signal transducer and activator of transcription 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06411","source_qa_id":"medium_divergent_branch_01097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"USP18 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_06412 | UBAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, VPS28, and VPS37.' Which disease is associated with the gene identified in this specifi... | hereditary spastic paraplegia 53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06412","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that ubiquitin associated protein 1 (UBAP1), a s... | |
medium_divergent_branch_06413 | GTF2I interacts with multiple genes. One interaction is supported by evidence stating: 'When nuclear extracts (NE) of HeLa cells were subjected to adsorption on a fusion protein containing glutathione S-transferase (GST) and Gal3, the general transcription factor II-I (TFII-I) was identified by mass spectrometry as one... | Galectin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06413","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GTF2I interacts with multiple genes. One interaction is supported by evidence stating: 'When nuclear extracts (NE) of HeLa cells were subjected to ad... | |
medium_divergent_branch_06414 | MRPL44 is associated with multiple biological processes. One association is supported by evidence stating that the gene encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate in close proximity to the tunnel exit of the yeast mitochondrial ribosome. Which broader biological proc... | translational elongation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRPL44 is associated with multiple biological processes. One association is supported by evidence stating that the gene encodes a protein in the larg... | |
medium_divergent_branch_06416 | CXCR5 interacts with multiple G-protein alpha subunits. One specific interaction is supported by evidence showing that a complex containing Gαi2, Gβ3, and Gγ9 couples to CXCR5 in C4-2B and PC3 cell lines and dissociates upon CXCL13 stimulation. Which protein is encoded by the gene corresponding to this specific interac... | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06416","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCR5 interacts with multiple G-protein alpha subunits. One specific interaction is supported by evidence showing that a complex containing Gαi2, Gβ3... | |
medium_divergent_branch_06417 | SFRP2 is associated with multiple biological processes. One association is supported by evidence stating that sFRPs inhibit the migration of glioma cells. Which biological process, connected to this specific SFRP2-associated process via a 'negatively regulates' relationship, is the target of that regulation? | cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06417","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFRP2 is associated with multiple biological processes. One association is supported by evidence stating that sFRPs inhibit the migration of glioma c... | |
medium_divergent_branch_06418 | WNT7A is associated with multiple biological processes. One association is supported by evidence that Wnts 7a and 7b stimulate the proliferation of neurogenic progenitors and increase the number of cells capable of generating primary neurospheres. Which biological process, connected to the process supported by this evi... | cell development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT7A is associated with multiple biological processes. One association is supported by evidence that Wnts 7a and 7b stimulate the proliferation of n... | |
medium_divergent_branch_06420 | ELF3 interacts with multiple genes. One interaction is supported by evidence stating: 'We have determined that [Protein A], Ku86, p300, and CREB-binding protein (CBP) are ESE-1 interacting proteins.' Which protein is encoded by the gene connected to ELF3 through this specific interaction? | DNA repair protein Ku70 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06420","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELF3 interacts with multiple genes. One interaction is supported by evidence stating: 'We have determined that [Protein A], Ku86, p300, and CREB-bind... | |
medium_divergent_branch_06421 | The proximal carpal endochondral element is a type of two distinct anatomical structures. One of these structures is explicitly described in the evidence as being part of a forelimb. Which of these two structures is the proximal carpal endochondral element a subtype of, given that this specific structure is part of a f... | mesopodial skeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06421","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The proximal carpal endochondral element is a type of two distinct anatomical structures. One of these structures is explicitly described in the evid... | |
medium_divergent_branch_06422 | KCNA3 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that 'FRET analysis and pharmacology confirm the presence of functional hybrid channels.' Which protein is encoded by the gene corresponding to this specific interaction partner? | Potassium voltage-gated channel subfamily A member 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNA3 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that 'FRET analysis and pharmacology confi... | |
medium_divergent_branch_06423 | The gene PRCD is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 19.11 TPM, a z-score of 2.23, and a fold enrichment of 9.33. Which cell type, defined by these statistics, is a subtype of the final answer cell type? | mature B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06423","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PRCD is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 19.11 TPM, a z-score of 2... | |
medium_divergent_branch_06424 | CRKL interacts with multiple proteins. One interaction is supported by evidence stating: 'The present study demonstrates that erythropoietin (Epo) and IL-3 induce tyrosine phosphorylation of the SH2/SH3-containing adapter protein CrkL and its transient association with tyrosine-phosphorylated [protein encoded by PTPN11... | Tyrosine-protein phosphatase non-receptor type 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRKL interacts with multiple proteins. One interaction is supported by evidence stating: 'The present study demonstrates that erythropoietin (Epo) an... | |
medium_divergent_branch_06425 | The biological process 'negative regulation of T-helper cell differentiation' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of T-helper cell differentiation. This process is a subtype of two distinct broader biological processes. One of these broader processes is specifically... | CD4-positive, alpha-beta T cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06425","source_qa_id":"medium_divergent_branch_01415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of T-helper cell differentiation' is defined as any p... | |
medium_divergent_branch_06426 | SOD1 interacts with multiple genes. One of these interacting partners is characterized by its ability to bind ATG8 family proteins, with a preference for LC3C, and it directly interacts with SOD1. Which disease is associated with this specific interacting gene through genomic alterations? | colon carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06426","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOD1 interacts with multiple genes. One of these interacting partners is characterized by its ability to bind ATG8 family proteins, with a preference... | |
medium_divergent_branch_06427 | SGK1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating: 'The N termini of the WNKs also have the capacity to interact with SGK1.' Which protein, connected to SGK1 via an interaction, is encoded by the gene corresponding to this entity? | Serine/threonine-protein kinase WNK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06427","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SGK1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating: 'The N termini of the WNKs also have t... | |
medium_divergent_branch_06428 | SNX27 is involved in a process described by evidence stating: 'These previously unreported results indicate that SNX27 is a participant in NK cell polarization, as a mediator or target of the mechanism.' Which biological process, connected to this NK cell polarization process via a 'part of' relationship, is the correc... | natural killer cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06428","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNX27 is involved in a process described by evidence stating: 'These previously unreported results indicate that SNX27 is a participant in NK cell po... | |
medium_divergent_branch_06431 | MAP3K7 (also known as TAK1) interacts with multiple proteins. One specific interaction partner is described as interacting with the TAK1-TAB1 complex and the IKKα/β-NEMO complex. Which disease is associated with this specific interaction partner? | pseudo-TORCH syndrome 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06431","source_qa_id":"medium_divergent_branch_06794","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MAP3K7 (also known as TAK1) interacts with multiple proteins. One specific interaction partner is... | |
medium_divergent_branch_06432 | BMPR2 is associated with multiple biological processes. One specific association is supported by evidence showing that RNA interference-mediated knockdown of BMPR2 inhibits the osteogenic differentiation of human adipose-derived stem cells (hASCs). Identify the cell type that is linked to this specific biological proce... | osteochondral skeletal stem cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06432","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMPR2 is associated with multiple biological processes. One specific association is supported by evidence showing that RNA interference-mediated knoc... | |
medium_divergent_branch_06434 | MLH1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using a yeast two-hybrid assay, we show that these MutL homologues can form heterodimers by interacting with the same amino acid residues of hMLH1, residues 492-742.' Which biological process is the gene involved in this spe... | mismatch repair | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06434","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MLH1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using a yeast two-hybrid assay, we show that these Mu... | |
medium_divergent_branch_06435 | ARNT interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that ARNT uses a single PAS domain to interact with two coiled coil coactivators, a TRIP family member and CoCoA.' Which disease is associated with the gene described in this evidence via a biomarker relationshi... | renal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06435","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARNT interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that ARNT uses a single PAS domain to in... | |
medium_divergent_branch_06438 | The gene OCLN interacts with multiple other genes. One specific interaction is supported by evidence stating: 'We have identified casein kinase I epsilon (CKI epsilon) as a binding partner for the C-terminal cytoplasmic domain of occludin by yeast two-hybrid screening.' Which protein is encoded by the gene that interac... | Casein kinase I isoform epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene OCLN interacts with multiple other genes. One specific interaction is supported by evidence stating: 'We have identified casein kinase I eps... | |
medium_divergent_branch_06439 | EPB41L3 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using yeast two-hybrid interaction cloning, we identified three 14-3-3 isoforms, beta, gamma and eta, to be DAL-1/Protein 4.1B-binding proteins.' Which disease is associated with the gene identified in this specific inte... | alcohol abuse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06439","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPB41L3 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using yeast two-hybrid interaction cloning, we id... | |
medium_divergent_branch_06440 | ACTL6B interacts with multiple proteins. One interaction is supported by evidence stating: 'No difference was observed between ArpNalpha and beta in subcellular localization and interaction with the ATPase subunit of mammalian SWI/SNF chromatin remodeling complex.' Which protein, connected to ACTL6B via this interactio... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06440","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACTL6B interacts with multiple proteins. One interaction is supported by evidence stating: 'No difference was observed between ArpNalpha and beta in ... | |
medium_divergent_branch_06441 | AKR1B10 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'In cultured cells, AKR1B10 was present in lysosomes and was secreted with cathepsin D, a lysosomal marker.' Which cellular component, connected to the component identified by thi... | lytic vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06441","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKR1B10 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'In cult... | |
medium_divergent_branch_06442 | KIF21A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'In vitro, KIF21A suppresses microtubule growth and inhibits catastrophes.' Which biological process is connected to this specific process through the 'regulates' relati... | microtubule depolymerization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06442","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF21A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating... |
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