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medium_hidden_intermediate_10799 | Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with MTA2. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE119117) shows a log2 fold change of approximately -1.226 and an adjusted p-value of 0.00735. Which protein is encoded by this ge... | Histone H2A.Z | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10799","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with MTA2. Experimental data for this int... | |
medium_hidden_intermediate_10800 | AQP1 is associated with multiple molecular functions that are subtypes of transmembrane transporter activity. One such function is characterized by the ability to enable the transfer of nitric oxide (nitrogen monoxide) from one side of a membrane to the other. Which biological process is this specific nitric oxide-rela... | nitric oxide transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10800","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"AQP1 is associated with multiple molecular functions that are subtypes of transmembrane transporter activity. One such funct... | |
medium_hidden_intermediate_10801 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the axoneme. Evidence for this gene in choroid plexus epithelium reports a log2 fold change of approximately -1.301 and an adjusted p-value of 0.005654. Which disease is associated with this gene? | ciliary dyskinesia, primary, 48, without situs inversus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10801","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the axoneme. Evidence for... | |
medium_hidden_intermediate_10802 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables N-acyltransferase activity. Transcriptomic data for this gene reports a log2 fold change of approximately 1.108 and an adjusted p-value of 0.04795. Which protein is encoded by this gene? | Phospholipase A and acyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables N-acyltransferase activity. Trans... | |
medium_hidden_intermediate_10803 | A gene is downregulated by Cardiovirus A and associated with breast carcinoma. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.293 and an adjusted p-value of 0.01156. Which biological process is this gene involved in? | negative regulation of epidermal growth factor-activated receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10803","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and associated with breast carcinoma. Experimental data for this gene in a cervical... | |
medium_hidden_intermediate_10806 | Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to the Neuronal System via a participation relationship. One of these genes exhibits a log2 fold change of -1.263 and an adjusted p-value of 0.008852 in peripheral blood mononuclear cells. Which disease is associated w... | arteriosclerosis disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to the Neuronal System... | |
medium_hidden_intermediate_10808 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to MED20. This specific gene exhibits a log2 fold change of 1.570 and an adjusted p-value of 7.027e-11. Which protein is encoded by this gene? | Mediator of RNA polymerase II transcription subunit 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to MED20. Thi... | |
medium_hidden_intermediate_10811 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is identified that is downregulated by the virus and participates in Chaperonin-mediated protein folding. This specific gene exhibits a log2 fold change of -1.044 and an adjusted p-value of 0.02729. Which protein is encoded by this ge... | Kinesin-like protein KIF13A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10811","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is identified that is downregulated by... | |
medium_hidden_intermediate_10812 | Human immunodeficiency virus 1 downregulates a gene that participates in post-translational protein phosphorylation. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -2.844 and an adjusted p-value of 0.01268. Which protein is encoded by this gene? | Follistatin-related protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in post-translational protein phosphorylation. In a st... | |
medium_hidden_intermediate_10813 | Rhinovirus A infection leads to the downregulation of certain genes, whose products are found in blood microparticles. One such gene exhibits a log2 fold change of -1.106 and an adjusted p-value of 0.009834 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Apolipoprotein L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes, whose products are found in blood microparticles. One s... | |
medium_hidden_intermediate_10814 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in signal transduction. Experimental data for this gene in foreskin fibroblast cell lines shows a log2 fold change of approximately -1.07 and an adjusted p-value of approximately 0.043. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in signal transduction. Experimental data for th... | |
medium_hidden_intermediate_10815 | In a study of bronchial epithelial cells infected with Influenza A virus (GSE147507), a specific gene is downregulated and its product is located in the Golgi membrane. Evidence for this gene reports a log2 fold change of -1.547 and an adjusted p-value of 0.001289. Which protein is encoded by this gene? | ATP-binding cassette sub-family A member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10815","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells infected with Influenza A virus (GSE147507), a specific gene is downregulated and i... | |
medium_hidden_intermediate_10816 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for colon carcinoma. This specific gene exhibits a log2 fold change of 2.460 and an adjusted p-value of 0.01134. Which protein is encoded by this gene? | Thy-1 membrane glycoprotein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_10818 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Chromosome Maintenance. One of these genes exhibits a log2 fold change of -1.289 and an adjusted p-value of 0.01121 in a specific study. Which cellular component is the location of this specific gene? | chromosome, centromeric region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Chromosome Maintenan... | |
medium_hidden_intermediate_10820 | Rhinovirus A infection leads to the downregulation of specific genes that are localized in the cytoplasm. One such gene exhibits a log2 fold change of approximately -3.06 and an adjusted p-value of 0.0008762 in cytotoxic T-lymphocytes. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of specific genes that are localized in the cytoplasm. One such gene exhi... | |
medium_hidden_intermediate_10822 | SEC61B interacts with a protein that is located in the endoplasmic reticulum membrane. Evidence indicates that this protein belongs to the VAP family and functions as a major ER-organelle tether. Which cell type is this protein enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10822","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SEC61B interacts with a protein that is located in the endoplasmic reticulum membrane. Evidence indicates that this protein ... | |
medium_hidden_intermediate_10823 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RAP1GDS1. Evidence for this gene reports a log2 fold change of 1.376 and an adjusted p-value of 0.0003347. Which disease is associated with this gene through genomic alterations? | Noonan syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RAP1GDS1. Evidence for thi... | |
medium_hidden_intermediate_10824 | The orbitosphenoid endochondral element is a part of an anatomical structure, which is in turn a part of the neurocranium. Evidence regarding this intermediate structure describes it as 'An orbitosphenoid bone or its cartilage or pre-cartilage precursor.' What is the general anatomical classification (is_a) of this int... | subdivision of skeletal system | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The orbitosphenoid endochondral element is a part of an anatomical structure, which is in turn a part of the neurocranium. E... | |
medium_hidden_intermediate_10826 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in TAK1-dependent IKK and NF-kappa-B activation. Evidence for one such gene reports a log2 fold change of 1.236 and an adjusted p-value of 0.04394. Which protein is encoded by that gene? | NF-kappa-B inhibitor-interacting Ras-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10826","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in TAK1-dependent IKK and NF-kapp... | |
medium_hidden_intermediate_10827 | Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to TRADD via a binding relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.11 and an adjusted p-value of approximately 0.048. Which protein is encoded ... | Spermatogenesis-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10827","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to TRADD via a bind... | |
medium_hidden_intermediate_10828 | Hepacivirus C upregulates a gene that is enriched in natural killer cells. Evidence for one such gene reports a log2 fold change of 2.868 and an adjusted p-value of 0.003232. Which biological process is this gene involved in? | tRNA dihydrouridine synthesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is enriched in natural killer cells. Evidence for one such gene reports a log2 fold ch... | |
medium_hidden_intermediate_10829 | Vaccinia virus upregulates multiple genes that enable signaling receptor binding. One such gene exhibits a log2 fold change of 2.803 and an adjusted p-value of 1.561e-05 in cervical adenocarcinoma cell lines. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates multiple genes that enable signaling receptor binding. One such gene exhibits a log2 fold change ... | |
medium_hidden_intermediate_10830 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' interaction and to UBE2M via a 'binds' interaction. One of these genes exhibits a log2 fold change of -2.518 and an adjusted p-value of 0.04072 in a specific study. Which biological process is this specific ... | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' interaction... | |
medium_hidden_intermediate_10831 | A gene is downregulated by Cardiovirus A and is enriched in eosinophils. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -2.261 and an adjusted p-value of 0.02734. Which protein is encoded by this gene? | Forkhead box protein N2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and is enriched in eosinophils. Experimental data for this gene in a cervical adeno... | |
medium_hidden_intermediate_10832 | Measles morbillivirus downregulates a gene that participates in chromatin modifying enzymes. Evidence for one such gene reports a log2 fold change of -2.040 and an adjusted p-value of 0.002849. Which protein is encoded by that gene? | Protein-arginine deiminase type-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in chromatin modifying enzymes. Evidence for one such gene repo... | |
medium_hidden_intermediate_10833 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that participates in biological oxidations. This gene exhibited a log2 fold change of approximately 2.057 and an adjusted p-value of approximately 0.042. What molecular function is enabled by this gene? | arsenite methyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10833","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that parti... | |
medium_hidden_intermediate_10834 | In a study of vascular endothelial cells (GSE16354), a gene was found to be upregulated by Human gammaherpesvirus 8 and involved in the positive regulation of inflammatory response. This gene exhibited a log2 fold change of approximately 2.39 and an adjusted p-value of 0.0158. Which protein is encoded by this gene? | Granzyme K | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a gene was found to be upregulated by Human gammaherpesvirus 8 and invo... | |
medium_hidden_intermediate_10836 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by Nuclear Receptors. Experimental data for this gene shows a log2 fold change of -1.051 and an adjusted p-value of 0.01019. Which cellular component is this gene located in? | Golgi apparatus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by Nuclear Re... | |
medium_hidden_intermediate_10837 | Pegivirus C is reported to downregulate a gene that participates in Glycolysis. Evidence for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -2.353 and an adjusted p-value of 0.000271. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in Glycolysis. Evidence for this gene in peripheral blood m... | |
medium_hidden_intermediate_10839 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables aminopeptidase activity. In a specific study, this gene exhibited a log2 fold change of 1.785 and an adjusted p-value of 0.01172. Which protein is encoded by this gene? | Xaa-Pro aminopeptidase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables aminopeptidase activity. In a specific... | |
medium_hidden_intermediate_10840 | A gene is upregulated by Human gammaherpesvirus 8 and serves as a biomarker for stroke disorder. Experimental data for this gene in umbilical vein endothelial cells (study GSE119608) reports a log2 fold change of approximately 1.24 and an adjusted p-value of 0.037. Which disease is associated with this gene? | inflammatory disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and serves as a biomarker for stroke disorder. Experimental data for this ... | |
medium_hidden_intermediate_10841 | Zika virus downregulates a gene that interacts with STIM1. In glioma stem cells, one such gene exhibits a log2 fold change of approximately -1.48 and an adjusted p-value of 0.0117. Which protein is encoded by this gene? | PDZ domain-containing protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10841","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with STIM1. In glioma stem cells, one such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_10842 | Hepacivirus C is reported to upregulate a gene that subsequently binds to SNRNP40. Experimental data for one such intermediate gene indicates a log2 fold change of 1.114 and an adjusted p-value of 0.02696. Which protein is encoded by this specific gene? | RNA helicase aquarius | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10842","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently binds to SNRNP40. Experimental data for one such intermedia... | |
medium_hidden_intermediate_10844 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that enables ubiquitin-like ligase-substrate adaptor activity. One such gene exhibited a log2 fold change of 1.083 and an adjusted p-value of 0.02313. Which protein is encoded by this specific ge... | F-box/LRR-repeat protein 19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10844","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene... | |
medium_hidden_intermediate_10846 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in intracellular signaling by second messengers. Evidence for this gene reports a log2 fold change of -1.068 and an adjusted p-value of 0.006799. Which protein is encoded by this gene? | Polyhomeotic-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in intracellular signaling by s... | |
medium_hidden_intermediate_10847 | A gene is upregulated by Primate bocaparvovirus 1 and is involved in the antimicrobial humoral immune response mediated by antimicrobial peptide. Evidence for this gene reports a log2 fold change of 1.122 and an adjusted p-value of 0.03721. Which protein is encoded by this gene? | C-C motif chemokine 28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is involved in the antimicrobial humoral immune response mediated by a... | |
medium_hidden_intermediate_10848 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for adult glioblastoma. Experimental data for this gene reports a log2 fold change of 3.844 and an adjusted p-value of 0.03405. Which disease is associated with this gene? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for adult glioblast... | |
medium_hidden_intermediate_10849 | A gene is upregulated by Primate bocaparvovirus 1 and is located in the membrane. Evidence for this gene reports a log2 fold change of 1.143 and an adjusted p-value of 0.04941. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is located in the membrane. Evidence for this gene reports a log2 fold... | |
medium_hidden_intermediate_10850 | Human immunodeficiency virus 1 upregulates a gene that enables NAD+-protein-lysine ADP-ribosyltransferase activity. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of 1.025 and an adjusted p-value of 0.005167. Which protein is encoded by this gene? | Protein mono-ADP-ribosyltransferase PARP16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables NAD+-protein-lysine ADP-ribosyltransferase activity. In a stu... | |
medium_hidden_intermediate_10853 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to spondylitis via association. One of these genes was reported in a study with a log2 fold change of 2.534 and an adjusted p-value of 0.01568. Which protein is encoded by this specific gene? | Kinesin-like protein KIF21B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10853","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to spondylitis via associ... | |
medium_hidden_intermediate_10854 | Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to breast carcinoma via a biomarker relationship. One of these genes is associated with a log2 fold change of 1.192 and an adjusted p-value of 0.03034. Which protein is encoded by this specific gene? | Syndecan-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to breast carcinoma via a biomar... | |
medium_hidden_intermediate_10855 | COG4 interacts with a specific small GTPase that possesses protein binding activity. Evidence identifies this GTPase as a key factor that recruits the HOPS complex onto autophagic vesicles. Which protein is encoded by this gene? | Ras-related protein Rab-39A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COG4 interacts with a specific small GTPase that possesses protein binding activity. Evidence identifies this GTPase as a ke... | |
medium_hidden_intermediate_10856 | Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Evidence for this gene reports a log2 fold change of 2.443 and an adjusted p-value of 0.0004149. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10856","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of transcription by RNA polyme... | |
medium_hidden_intermediate_10857 | In the study GSE131840, a gene is upregulated by Measles morbillivirus and associated with breast carcinoma. This specific gene exhibits a log2 fold change of 1.920 and an adjusted p-value of 0.001128. Which protein is encoded by this gene? | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE131840, a gene is upregulated by Measles morbillivirus and associated with breast carcinoma. This specific g... | |
medium_hidden_intermediate_10858 | Influenza A virus upregulates a gene that participates in the association of TriC/CCT with target proteins during biosynthesis. Evidence for this gene shows a log2 fold change of 1.432 and an adjusted p-value of 3.281e-06. Which protein is encoded by this gene? | Probable T-complex protein 1 subunit zeta-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10858","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a gene that participates in the association of TriC/CCT with target proteins during biosynthes... | |
medium_hidden_intermediate_10859 | BMP2 is involved in a biological process that is a type of cell differentiation. Evidence regarding this process states: 'These results suggest different mechanisms for BMP-2/4- and BMP-6/7-induced osteoblastic differentiation in primary hMSC.' Which cell type is the result of the acquisition of features associated wit... | osteoblast | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"BMP2 is involved in a biological process that is a type of cell differentiation. Evidence regarding this process states: 'Th... | |
medium_hidden_intermediate_10860 | Two distinct pharmacological agents are known to interact with both Morphine and Dexfenfluramine. One of these agents belongs to a class of drugs described in the following evidence: 'While tricyclics had no effect on basal pain responsivity, they potentiated morphine analgesia in rank-order with their potency as TLR4 ... | fibromyalgia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10860","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct pharmacological agents are known to interact with both Morphine and Dexfenfluramine. One of these agents belong... | |
medium_hidden_intermediate_10861 | Zika virus downregulates a specific gene, which in turn interacts with NRAS. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.20 and an adjusted p-value of 0.002154. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10861","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with NRAS. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_10862 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain genes that are located in the extracellular matrix. One such gene exhibited a log2 fold change of approximately -1.675 and an adjusted p-value of 0.02896. Which protein is encoded by this specific gen... | Amelotin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10862","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain gene... | |
medium_hidden_intermediate_10863 | A gene is upregulated by Vaccinia virus and involved in protein complex oligomerization. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.307 and an adjusted p-value of 1.879e-05. Which disease is associated with this gene? | muscular dystrophy, limb-girdle, autosomal recessive 29 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10863","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and involved in protein complex oligomerization. Experimental data for this gene in ... | |
medium_hidden_intermediate_10864 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in MAPK6/MAPK4 signaling. Experimental evidence for this gene reports a log2 fold change of approximately -1.90 and an adjusted p-value of 0.0304. Which protein is encoded by this gene? | Cdc42 effector protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in MAPK6/MAPK4 signaling. ... | |
medium_hidden_intermediate_10865 | Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription repressor activity, RNA polymerase II-specific. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibits a log2 fold change of approximately -1.46 and an adjusted p-value of 0.0038. Which protein is encod... | Myeloid zinc finger 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription repressor activity, RNA polymerase I... | |
medium_hidden_intermediate_10866 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with mammary neoplasms, animal. Evidence for this gene reports a log2 fold change of 1.118 and an adjusted p-value of 0.02313. Which disease is connected to that gene through the relation 'biomarker'? | endometrial carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with mammary neoplasms, ani... | |
medium_hidden_intermediate_10867 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn enables integrin binding. This gene exhibited a log2 fold change of -2.847 and an adjusted p-value of 0.02513. Which protein is encoded by this gene? | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10867","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to downregulate a sp... | |
medium_hidden_intermediate_10868 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that encodes a protein located at the cell surface. One such gene exhibited a log2 fold change of approximately 2.16 and an adjusted p-value of 3.37e-15. Which protein is encoded by this specific gene? | Adipocyte plasma membrane-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that encodes... | |
medium_hidden_intermediate_10869 | Zika virus upregulates a gene that is located in the membrane. Evidence for this gene reports a log2 fold change of approximately 3.10 and an adjusted p-value of 0.0307. Which disease is associated with this gene? | renal cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is located in the membrane. Evidence for this gene reports a log2 fold change of approxim... | |
medium_hidden_intermediate_10870 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by Nuclear Receptors. Evidence for this gene reports a log2 fold change of approximately -2.005 and an adjusted p-value of 0.02596. Which disease is associated with this gene as a biomarker? | osteoporosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10870","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by Nuclear Re... | |
medium_hidden_intermediate_10872 | Zika virus downregulates a gene that is located on the cell surface. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.767 and an adjusted p-value of 0.007752. Which disease is associated with this gene as a biomarker? | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located on the cell surface. In a study of glioma stem cells (GSE114907), this gene ... | |
medium_hidden_intermediate_10873 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the negative regulation of transcription by RNA polymerase II. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicate a log2 fold change of -1.412 and an adjusted p-value of 0.003326... | chromatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10873","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the negative regulation of transc... | |
medium_hidden_intermediate_10875 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in O-linked glycosylation. One of these genes exhibits a log2 fold change of -1.172 and an adjusted p-value of 0.04891 in a specific study. Which disease is associated with this gene? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in O-linked glycosylati... | |
medium_hidden_intermediate_10877 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Membrane Trafficking. One of these genes exhibits a log2 fold change of 1.055 and an adjusted p-value of 0.003416 in macrophages (study GSE108897). Which disease is associated with this specific gene? | sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10877","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Membrane Trafficking. One of these genes exhi... | |
medium_hidden_intermediate_10878 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables sequence-specific DNA binding. Experimental data for this gene reports a log2 fold change of -2.317 and an adjusted p-value of 0.004246. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables sequence-specific DNA binding. ... | |
medium_hidden_intermediate_10881 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participates in Metabolism. This specific gene exhibits a log2 fold change of 1.228 and an adjusted p-value of 0.03556. Which molecular function is enabled by this gene? | inositol-1,4,5-trisphosphate 3-kinase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10881","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participate... | |
medium_hidden_intermediate_10882 | Pegivirus C is reported to downregulate a specific gene that participates in Cytokine Signaling in the Immune system. Transcriptomic data for this gene indicates a log2 fold change of -1.486 and an adjusted p-value of 0.000548. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10882","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in Cytokine Signaling in the Immune system. Transc... | |
medium_hidden_intermediate_10883 | Zika virus downregulates a specific gene, which in turn interacts with YWHAZ. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.304 and an adjusted p-value of 0.0273. Which biological process is this gene involved in? | protein phosphorylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10883","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with YWHAZ. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_10886 | In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with SUMO2. One of these genes exhibits a log2 fold change of 1.070 and an adjusted p-value of 0.002831. Which protein is encoded by this specific gene? | Sentrin-specific protease 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10886","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with SUMO2... | |
medium_hidden_intermediate_10888 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and serving as biomarkers for bipolar disorder. One of these genes exhibits a log2 fold change of 6.375 and an adjusted p-value of 0.02307. Which protein is encoded by this specific gene? | Early growth response protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10888","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and serving as bio... | |
medium_hidden_intermediate_10889 | In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, two genes are identified as being upregulated by the virus and enriched in eosinophils. One of these genes exhibits a log2 fold change of approximately 1.396 and an adjusted p-value of 8.527e-07. Which protein does this specifi... | UBL5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, two genes are identified as bei... | |
medium_hidden_intermediate_10890 | Zika virus downregulates a gene that enables ubiquitin-protein transferase activity. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -3.16 and an adjusted p-value of 0.0126. Which protein is encoded by this specific gene? | F-box/LRR-repeat protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables ubiquitin-protein transferase activity. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_10892 | Human respirovirus 3 is reported to downregulate a specific gene that enables protein binding. In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), this gene exhibited a log2 fold change of -1.430 and an adjusted p-value of 0.04933. Which disease is associated with genomic alterations in this gene? | major depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human respirovirus 3 is reported to downregulate a specific gene that enables protein binding. In a study of non-small cell ... | |
medium_hidden_intermediate_10895 | In a study of vascular endothelial cells (GSE16354), a gene is upregulated by Human gammaherpesvirus 8 and interacts with RPA3. This gene exhibits a log2 fold change of approximately 1.237 and an adjusted p-value of 0.01709. Which protein is encoded by this gene? | C-1-tetrahydrofolate synthase, cytoplasmic | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10895","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a gene is upregulated by Human gammaherpesvirus 8 and interacts with RP... | |
medium_hidden_intermediate_10896 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product enables protein kinase binding. Experimental data for this gene reports a log2 fold change of approximately 1.177 and an adjusted p-value of 0.04967. Which protein is encoded by this gene? | Cyclin-dependent kinase 4 inhibitor C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10896","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product enables protein kinas... | |
medium_hidden_intermediate_10897 | In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and is involved in phosphorylation. Evidence for this specific gene reports a log2 fold change of 1.034 and an adjusted p-value of 0.03916. Which protein is encoded by this gene? | NAD kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and is involved in phosphorylation. Evidence fo... | |
medium_hidden_intermediate_10898 | Zika virus downregulates a specific gene that is involved in the activation of NF-kappaB-inducing kinase activity. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.096 and an adjusted p-value of 0.008494. Which cellular component is this gene located ... | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10898","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the activation of NF-kappaB-inducing kinase activity. Experimen... | |
medium_hidden_intermediate_10899 | Two genes are downregulated by Human immunodeficiency virus 1 and participate in Glutathione synthesis and recycling. One of these genes exhibits a log2 fold change of -1.168 and an adjusted p-value of 0.01555 in macrophages. Which disease is associated with genomic alterations in this specific gene? | chronic granulomatous disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10899","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and participate in Glutathione synthesis and recycling. One of... | |
medium_hidden_intermediate_10900 | Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to breast carcinoma via a biomarker relationship. One of these genes exhibits a log2 fold change of approximately -1.167 and an adjusted p-value of 0.0003792 in macrophages (study GSE108897). Which biological process is this sp... | positive regulation of cell population proliferation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10900","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to breast carcinoma via a bioma... | |
medium_hidden_intermediate_10901 | Human immunodeficiency virus 1 downregulates a gene that participates in mitochondrial biogenesis. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -1.091 and an adjusted p-value of 0.02587. Which biological process is this specific gene involved in? | regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in mitochondrial biogenesis. In a study of macrophages... | |
medium_hidden_intermediate_10902 | In the study GSE157852 involving choroid plexus epithelium, Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the DNA damage response. This specific gene exhibits a log2 fold change of approximately 1.209 and an adjusted p-value of 3.891e-05. Which protein is encoded by this g... | Biorientation of chromosomes in cell division protein 1-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10902","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE157852 involving choroid plexus epithelium, Severe acute respiratory syndrome-related coronavirus upregulate... | |
medium_hidden_intermediate_10903 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in NR1H2 and NR1H3-mediated signaling. One of these genes shows a log2 fold change of 1.264 and an adjusted p-value of 0.0244 in a specific study. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10903","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in NR1H2 and NR1H3-mediated signaling. One of th... | |
medium_hidden_intermediate_10904 | Zika virus downregulates a gene that is associated with prostate cancer. Experimental data for this gene in glioma stem cells (study GSE114907) show a log2 fold change of -2.578 and an adjusted p-value of 0.01212. Which protein is encoded by this gene? | Neuropeptide Y receptor type 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with prostate cancer. Experimental data for this gene in glioma stem cell... | |
medium_hidden_intermediate_10906 | Human immunodeficiency virus 1 downregulates a gene that enables glycerophospholipid phospholipase A1 activity. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -3.168 and an adjusted p-value of 0.009641. Which protein is encoded by this specific gene? | Phospholipase ABHD3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10906","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables glycerophospholipid phospholipase A1 activity. In a study o... | |
medium_hidden_intermediate_10911 | Two genes are structurally linked to Natural killer T (NKT) cells via a 'has marker' relationship and to the negative regulation of interleukin-8 production via an 'involved in' relationship. One of these genes is described by the following evidence: 'Transient expression of Bcl-3 potently inhibited virus-inducible IL-... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10911","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Natural killer T (NKT) cells via a 'has marker' relationship and to the negative regula... | |
medium_hidden_intermediate_10913 | Pegivirus C downregulates a specific gene product that subsequently binds to PEX5. Experimental data for this intermediate entity in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of approximately -1.54 and an adjusted p-value of 0.0155. Which biological process is this intermedi... | macroautophagy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10913","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene product that subsequently binds to PEX5. Experimental data for this intermediate e... | |
medium_hidden_intermediate_10917 | Zika virus downregulates a gene that is involved in double-strand break repair via homologous recombination. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -4.544 and an adjusted p-value of 0.00922. Which protein is encoded by this specific gene? | Single-strand DNA endonuclease ASTE1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10917","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in double-strand break repair via homologous recombination. In a study of g... | |
medium_hidden_intermediate_10920 | Human alphaherpesvirus 3 upregulates a gene that participates in Interferon Signaling. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of 3.625 and an adjusted p-value of 2.619e-06. Which protein is encoded by this gene? | Interferon alpha-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10920","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in Interferon Signaling. Evidence for this gene in a melanoma ... | |
medium_hidden_intermediate_10921 | RBFOX2 interacts with a specific protein that enables protein binding. Evidence indicates that this protein contains a UHM ligand motif (ULM) in its C-terminus, which mediates interaction with the splicing factor U2AF65. Which disease is associated with this protein as a biomarker? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RBFOX2 interacts with a specific protein that enables protein binding. Evidence indicates that this protein contains a UHM l... | |
medium_hidden_intermediate_10923 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the basolateral plasma membrane. Experimental data for this gene in a cardiomyocyte cell line (study GSE151879) reports a log2 fold change of approximately 1.46 and an adjusted p-value of approximately 0.0101. Which disease... | prostate adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10923","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the basolateral plasma memb... | |
medium_hidden_intermediate_10925 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in keratan sulfate/keratin metabolism. Evidence for this gene reports a log2 fold change of 3.744 and an adjusted p-value of 0.014. Which biological process is this gene involved in? | lactosylceramide biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10925","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in keratan sulfate/keratin metabo... | |
medium_hidden_intermediate_10928 | Hepacivirus C is reported to downregulate a gene that enables protein kinase activity. Transcriptomic data for one such gene shows a log2 fold change of approximately -1.37 and an adjusted p-value of approximately 0.036. Which protein is encoded by this gene? | Cyclin-dependent kinase-like 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10928","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables protein kinase activity. Transcriptomic data for one such gene... | |
medium_hidden_intermediate_10929 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are downregulated and participate in cargo recognition for clathrin-mediated endocytosis. One of these genes exhibits a log2 fold change of -1.489 and an adjusted p-value of 0.04212. Which protein is encoded by this specific gene? | Synaptotagmin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10929","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are downregulated and participate in cargo recog... | |
medium_hidden_intermediate_10930 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cytolysis. Experimental data for this gene in lung cells reports a log2 fold change of approximately 3.18 and an adjusted p-value of 0.0046. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cytolysis. Experimental da... | |
medium_hidden_intermediate_10931 | In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), a specific gene is downregulated by the virus and enables protein kinase activity. This gene exhibits a log2 fold change of approximately -1.183 and an adjusted p-value of 0.02708. Which protein is encoded by this gene? | Serine/threonine-protein kinase N3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10931","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), a specific gene is downregulated by... | |
medium_hidden_intermediate_10934 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to GNA15 via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of -2.321 and an adjusted p-value of 0.04538. Which protein is encoded... | Endothelin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10934","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_10935 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in the RHO GTPase cycle. This specific gene exhibits a log2 fold change of 1.677 and an adjusted p-value of 0.001977. Which protein is encoded by this gene? | Adenosine 5'-monophosphoramidase HINT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in the... | |
medium_hidden_intermediate_10936 | Vaccinia virus infection leads to the downregulation of certain genes that are involved in B cell activation. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibited a log2 fold change of approximately -2.79 and an adjusted p-value of 0.0052. Which protein is encoded by this specific gene? | B-cell scaffold protein with ankyrin repeats | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the downregulation of certain genes that are involved in B cell activation. In a study of ... | |
medium_hidden_intermediate_10937 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in aerobic respiration and respiratory electron transport. In a study of foreskin fibroblast cell lines (GSE111036), one such downregulated gene exhibited a log2 fold change of -1.473 and an adjusted p-value of 0.04918. Which protein is encode... | Cytochrome c oxidase assembly protein COX18, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10937","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in aerobic respiration and respiratory electron... | |
medium_hidden_intermediate_10938 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in mitochondrion organization. One of these genes exhibits a log2 fold change of 1.606 and an adjusted p-value of 0.0087 in a specific study. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10938","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in mitochondrion organiz... | |
medium_hidden_intermediate_10940 | Enterovirus A upregulates a gene that is involved in the positive regulation of the ERK1 and ERK2 cascade. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibits a log2 fold change of approximately 2.19 and an adjusted p-value of approximately 0.016. Which protein does this specific gene interact with... | PJA2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10940","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is involved in the positive regulation of the ERK1 and ERK2 cascade. In a study of rha... | |
medium_hidden_intermediate_10942 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Fatty acid metabolism. One of these genes was reported in a study (GSE164073) on sclera cells with a log2 fold change of approximately 1.315 and an adjusted p-value of 0.01595. Which protein is encoded by this specific... | Very long chain fatty acid elongase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10942","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Fatty acid metabolism.... | |
medium_hidden_intermediate_10943 | Two genes are upregulated by Enterovirus A and participate in Glycerophospholipid biosynthesis. One of these genes exhibits a log2 fold change of approximately 1.01 and an adjusted p-value of approximately 0.016 in rhabdomyosarcoma cells. Which disease is associated with genomic alterations in this specific gene? | pure hereditary spastic paraplegia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10943","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and participate in Glycerophospholipid biosynthesis. One of these genes exhibits ... |
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