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medium_hidden_intermediate_10647 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Autophagy. Experimental data for this gene in lung cells show a log2 fold change of 2.218 and an adjusted p-value of 0.019. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10647","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Autophagy. Experimental d... | |
medium_hidden_intermediate_10649 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the negative regulation of apoptotic process via an 'involved in' relationship. One of these genes is reported in a study (GSE148729) using a colonic adenocarcinoma cell line, with a log2... | pulmonary emphysema | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10649","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_10651 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables nuclear thyroid hormone receptor binding. Evidence for one such gene reports a log2 fold change of 2.053 and an adjusted p-value of 2.255e-05. Which protein is encoded by that gene? | AT-rich interactive domain-containing protein 5A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables nuclear thyroid hormone receptor bindi... | |
medium_hidden_intermediate_10652 | A gene is downregulated by Primate bocaparvovirus 1 and participates in Heparan sulfate/heparin (HS-GAG) metabolism. Experimental evidence for this gene shows a log2 fold change of -1.136 and an adjusted p-value of 0.03986. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in Heparan sulfate/heparin (HS-GAG) metabolism. Experim... | |
medium_hidden_intermediate_10653 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in the response to elevated platelet cytosolic Ca2+. This gene exhibited a log2 fold change of 2.430 and an adjusted p-value of 3.75e-11. Which protein is encoded by this gene? | WD repeat-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10653","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_10655 | Pegivirus C is reported to downregulate a specific gene that is located in chromatin. Experimental data for this gene in peripheral blood mononuclear cells shows a log2 fold change of approximately -1.25 and an adjusted p-value of 0.0115. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is located in chromatin. Experimental data for this gene in per... | |
medium_hidden_intermediate_10656 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to USO1 via a 'binds' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.111 and an adjusted p-value of 0.04851. Which protein is encoded ... | Protein cornichon homolog 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10656","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_10658 | Hepacivirus C is linked to breast cancer via a gene that acts as a biomarker and is upregulated by the virus. One such gene exhibits a log2 fold change of 1.674 and an adjusted p-value of 0.008793. Which protein is encoded by this specific gene? | Forkhead box protein Q1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to breast cancer via a gene that acts as a biomarker and is upregulated by the virus. One such gene ... | |
medium_hidden_intermediate_10662 | Two distinct drugs are known to interact with both Phenytoin and St. John's Wort. One of these drugs is associated with evidence stating: 'Clinically significant drug interactions have been reported to occur when paclitaxel is administered with doxorubicin, cisplatin, or anticonvulsants (phenytoin, carbamazepine, and p... | head and neck cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10662","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Phenytoin and St. John's Wort. One of these drugs is associated with evid... | |
medium_hidden_intermediate_10663 | Zika virus downregulates a specific gene that participates in Viral Infection Pathways. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -1.013 and an adjusted p-value of 0.01591. Which disease is associated with this gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Viral Infection Pathways. Experimental data from glioma stem c... | |
medium_hidden_intermediate_10664 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and involved in signal transduction was found to have a log2 fold change of approximately 1.015 and an adjusted p-value of 0.04687. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and involved in si... | |
medium_hidden_intermediate_10665 | Zika virus infection leads to the upregulation of specific genes that enable RNA polymerase II cis-regulatory region sequence-specific DNA binding. One such gene exhibits a log2 fold change of 1.137 and an adjusted p-value of 0.002946 in neural stem cells. Which disease is associated with this gene as a biomarker? | osteosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of specific genes that enable RNA polymerase II cis-regulatory region sequenc... | |
medium_hidden_intermediate_10667 | Zika virus downregulates a gene that is located in the centriole. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -1.534 and an adjusted p-value of 0.006011. Which protein interacts with this gene product? | CEP19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the centriole. Experimental data from glioma stem cells (study GSE114907)... | |
medium_hidden_intermediate_10670 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with TRIM21. One of these genes exhibits a log2 fold change of 1.691 and an adjusted p-value of 0.02036 in macrophages. Which disease is associated with genomic alterations in this specific gene? | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with TRIM21. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_10671 | Measles morbillivirus upregulates a gene that enables DNA binding. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) show a log2 fold change of approximately 1.27 and an adjusted p-value of 0.0028. Which protein does this gene product bind to? | TP53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables DNA binding. Experimental data for this gene in pleural mesothelioma c... | |
medium_hidden_intermediate_10672 | Enterovirus A is reported to downregulate a specific gene, which is in turn associated with lung carcinoma. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicate a log2 fold change of approximately -2.20 and an adjusted p-value of approximately 0.0301. Which protein is encoded by this gen... | Tumor necrosis factor receptor superfamily member 27 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene, which is in turn associated with lung carcinoma. Experimental dat... | |
medium_hidden_intermediate_10674 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a specific gene that participates in Developmental Biology. This gene exhibited a log2 fold change of approximately -1.25 and an adjusted p-value of 0.04034. Which protein does this gene interact with? | DPYSL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a specific gene that p... | |
medium_hidden_intermediate_10675 | A gene serves as a marker for Microglial cells and is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for one such gene reports a mean expression of 60.98 TPM, a z-score of 1.79, and a fold enrichment of 3.20. Which disease is associated with this gene as a biomarker? | multiple sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Microglial cells and is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for o... | |
medium_hidden_intermediate_10677 | A specific protein is identified as a marker for Natural killer T (NKT) cells and is known to interact with TP53. Experimental evidence indicates that the inhibitory effect of Lys 372 methylation on Lys 370 methylation is caused, in part, by blocking the interaction between p53 and this protein. In which cellular compo... | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific protein is identified as a marker for Natural killer T (NKT) cells and is known to interact with TP53. Experiment... | |
medium_hidden_intermediate_10678 | In a study of Influenza A virus infection, a specific gene is upregulated and involved in protein autoubiquitination. Evidence for this gene reports a log2 fold change of approximately 1.11 and an adjusted p-value of 0.0003429. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and involved in protein autoubiquitination. Eviden... | |
medium_hidden_intermediate_10680 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with CDC42. One such gene exhibits a log2 fold change of approximately 1.50 and an adjusted p-value of 0.0165. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with CD... | |
medium_hidden_intermediate_10682 | Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in eosinophils. One such gene exhibits a log2 fold change of 1.721 and an adjusted p-value of 0.0003171 in foreskin fibroblast cell lines. Which protein is encoded by this specific gene? | Kelch-like protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in eosinophils. One such gene exhibits a log2 fold... | |
medium_hidden_intermediate_10683 | In a study of Measles morbillivirus infection, two genes are upregulated by the virus and both interact with the protein YWHAH. One of these genes exhibits a log2 fold change of approximately 1.56 and an adjusted p-value of 0.0085. Which protein is encoded by this specific gene? | Mitogen-activated protein kinase kinase kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are upregulated by the virus and both interact with the protein YWH... | |
medium_hidden_intermediate_10685 | Two genes are each upregulated by Measles morbillivirus and enriched in intermediate monocytes. One of these genes was reported in a study (GSE117668) with a log2 fold change of approximately 2.457 and an adjusted p-value of 0.001266. Which protein does this specific gene interact with? | RBM39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Measles morbillivirus and enriched in intermediate monocytes. One of these genes was repor... | |
medium_hidden_intermediate_10687 | Rift Valley fever phlebovirus upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold change of 4.946 and an adjusted p-value of 0.005159. Which disease is associated with this gene as a biomarker? | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10687","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_10688 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with TP53. One such gene exhibits a log2 fold change of approximately 1.315 and an adjusted p-value of 0.00486. Which protein is encoded by this specific gene? | BTB/POZ domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with TP... | |
medium_hidden_intermediate_10689 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn interacts with SNCA. This gene exhibited a log2 fold change of -1.997 and an adjusted p-value of 0.003561. Which protein is encoded by this gene? | Ubiquitin thioesterase OTU1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10689","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn i... | |
medium_hidden_intermediate_10690 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Glycosphingolipid metabolism. Evidence for this gene in a non-Hodgkin lymphoma cell line reports a log2 fold change of 1.862 and an adjusted p-value of 0.0425. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Glycosphingolipid metabolism. Evidence for this gene i... | |
medium_hidden_intermediate_10693 | Human immunodeficiency virus 1 downregulates a specific gene that participates in MAPK family signaling cascades. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of -4.405 and an adjusted p-value of 0.008794. Which disease is associated with genomic alterations in this g... | malignant colon neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene that participates in MAPK family signaling cascades. Experiment... | |
medium_hidden_intermediate_10695 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in cell adhesion. One such gene exhibits a log2 fold change of 2.081 and an adjusted p-value of 0.01352. Which protein is encoded by this specific gene? | Plexin-C1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10695","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in cell adhesion. ... | |
medium_hidden_intermediate_10696 | Two genes are structurally linked to Pegivirus C via downregulation and to KEAP1 via interaction. One of these genes exhibits a log2 fold change of -1.337 and an adjusted p-value of 0.02201 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to KEAP1 via interaction. One of these genes exhibit... | |
medium_hidden_intermediate_10697 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with gastric cancer. Experimental data for this gene reports a log2 fold change of 3.529 and an adjusted p-value of 0.009155. Which disease is linked to this gene through genomic alterations? | intellectual disability | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is associated with gastric cancer. Experi... | |
medium_hidden_intermediate_10698 | Two genes are upregulated by Human alphaherpesvirus 1 and both bind to NPM1. One of these genes exhibits a log2 fold change of 2.809 and an adjusted p-value of 0.003171 in a monocytic leukemia cell line. Which disease is associated with this specific gene? | astrocytoma (excluding glioblastoma) | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and both bind to NPM1. One of these genes exhibits a log2 fold change ... | |
medium_hidden_intermediate_10699 | Two genes are upregulated by Human immunodeficiency virus 1 and are involved in the negative regulation of transcription by RNA polymerase II. One of these genes exhibits a log2 fold change of approximately 2.025 and an adjusted p-value of 0.03089 in natural killer cells. Which disease is associated with this specific ... | adult lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are involved in the negative regulation of transcription by ... | |
medium_hidden_intermediate_10700 | Pegivirus C is associated with the downregulation of a specific gene, which in turn is linked to end-stage renal failure through genomic alterations. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.53 and an adjusted p-value of 0.007989. Which pro... | FERM domain containing 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of a specific gene, which in turn is linked to end-stage renal failure thr... | |
medium_hidden_intermediate_10702 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the antimicrobial humoral immune response mediated by antimicrobial peptide. Evidence for this gene reports a log2 fold change of 8.216 and an adjusted p-value of 0.03165. Which disease is associated with this gene as a bi... | obesity disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the antimicrobial humoral ... | |
medium_hidden_intermediate_10703 | Zaire ebolavirus infection has been linked to the upregulation of specific genes that serve as biomarkers for urinary bladder neoplasm. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately 1.64 and an adjusted p-value of 0.0227. Which protein is encoded... | Homeobox protein Hox-A9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection has been linked to the upregulation of specific genes that serve as biomarkers for urinary bladde... | |
medium_hidden_intermediate_10704 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to influenza via a biomarker relationship. One of these genes was reported in a study (GSE157852) involving choroid plexus epithelium cells, showing a log2 fold change of 3.386 and an adjusted p-value of 7... | Galactosylceramide sulfotransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10704","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to influe... | |
medium_hidden_intermediate_10705 | Two genes are downregulated by Human immunodeficiency virus 1 and located in extracellular vesicles. One of these genes exhibits a log2 fold change of -2.945 and an adjusted p-value of 0.01941 in macrophages (study GSE108897). Which disease is associated with this specific gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and located in extracellular vesicles. One of these genes exhi... | |
medium_hidden_intermediate_10706 | Measles morbillivirus upregulates a specific gene, which in turn encodes a protein that binds to KAT5. Experimental data for this gene reports a log2 fold change of approximately 2.255 and an adjusted p-value of 0.0007125. Which protein is encoded by this gene? | FIGNL1-interacting regulator of recombination and mitosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a specific gene, which in turn encodes a protein that binds to KAT5. Experimental data for... | |
medium_hidden_intermediate_10707 | Two genes are upregulated by Vaccinia virus and are involved in the positive regulation of transcription elongation by RNA polymerase II. One of these genes exhibits a log2 fold change of approximately 1.56 and an adjusted p-value of approximately 0.0002 in cervical adenocarcinoma cell lines. Which disease is associate... | neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are involved in the positive regulation of transcription elongation by RNA p... | |
medium_hidden_intermediate_10708 | BMP2 is involved in multiple biological processes that are types of cell differentiation. One such process is defined as the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte, where a chondrocyte is a polymorphic cell that forms cartilage. Which biological proce... | cartilage development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10708","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"BMP2 is involved in multiple biological processes that are types of cell differentiation. One such process is defined as the... | |
medium_hidden_intermediate_10709 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Signaling by Receptor Tyrosine Kinases. Evidence for this specific gene reports a log2 fold change of -1.285 and an adjusted p-value of 4.21e-05. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Signaling by Receptor Tyrosi... | |
medium_hidden_intermediate_10711 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to UBE2N via an interaction relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 2.51 and an adjusted p-value of 0.0224. Which prot... | E3 ubiquitin-protein ligase ZNRF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_10712 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn participates in MAPK1/MAPK3 signaling. Evidence for this specific gene reports a log2 fold change of approximately 1.196 and an adjusted p-value of 0.01661. Which protein is encoded by this g... | Acyl-protein thioesterase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_10713 | The orbitosphenoid is classified as a type of head bone via an intermediate anatomical category. Evidence regarding this intermediate category states: 'The bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young.' ... | neurocranium | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The orbitosphenoid is classified as a type of head bone via an intermediate anatomical category. Evidence regarding this int... | |
medium_hidden_intermediate_10714 | Two genes are upregulated by Vaccinia virus and participate in Signaling by Rho GTPases. One of these genes exhibits a log2 fold change of 1.677 and an adjusted p-value of 0.001977 in the specified dataset. Which cell type is this specific gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10714","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in Signaling by Rho GTPases. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_10715 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its protein product binds to RBBP7. This gene exhibits a log2 fold change of approximately 1.388 and an adjusted p-value of 0.0005631. Which protein is encoded by this gene? | AT-rich interactive domain-containing protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10715","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_10716 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Peptide hormone biosynthesis. Evidence for this gene reports a log2 fold change of 2.728 and an adjusted p-value of 0.001912. Which protein is encoded by this gene? | Inhibin beta E chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Peptide hormone biosynthe... | |
medium_hidden_intermediate_10717 | Pegivirus C is reported to downregulate a gene that enables magnesium ion binding. Experimental data for this gene shows a log2 fold change of -1.168 and an adjusted p-value of 0.002681. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables magnesium ion binding. Experimental data for this gene shows a l... | |
medium_hidden_intermediate_10718 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in Cell-cell junction organization. This specific gene exhibits a log2 fold change of approximately -1.001 and an adjusted p-value of 0.01146. What molecular function is enabled by this g... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_10720 | Human immunodeficiency virus 1 downregulates a gene that is located in the Golgi membrane. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -1.188 and an adjusted p-value of 0.01058. Which protein is encoded by this gene? | Palmitoyltransferase ZDHHC20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10720","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the Golgi membrane. Evidence for this gene in macroph... | |
medium_hidden_intermediate_10721 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in infectious disease processes. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of -1.535 and an adjusted p-value of 0.004765. Which disease is associated wi... | arthrogryposis, renal dysfunction, and cholestasis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in infectious disease processes. Transcr... | |
medium_hidden_intermediate_10722 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables ubiquitin-protein transferase activity. Evidence for one such gene reports a log2 fold change of 1.032 and an adjusted p-value of 0.007199. Which protein is encoded by that gene? | F-box only protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables ubiquitin-protein transferase activity... | |
medium_hidden_intermediate_10723 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the nucleoplasm. Evidence for this gene reports a log2 fold change of 1.119 and an adjusted p-value of 0.0003319. Which disease is associated with this gene through genomic alterations? | cervical cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the nucleoplasm. Evidence for ... | |
medium_hidden_intermediate_10726 | Two genes are structurally linked from Human betaherpesvirus 5 via an 'upregulates' relationship and subsequently to Basophil via an 'enriched in' relationship. One of these genes is associated with a log2 fold change of approximately 1.333 and an adjusted p-value of 0.0002767 in a specific study context. Which disease... | middle cerebral artery infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human betaherpesvirus 5 via an 'upregulates' relationship and subsequently to Basophi... | |
medium_hidden_intermediate_10728 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in MET Receptor Activation. One of these genes exhibits a log2 fold change of approximately 5.66 and an adjusted p-value of 0.0051 in macrophages. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10728","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in MET Receptor Activation. One of these genes e... | |
medium_hidden_intermediate_10732 | Pegivirus C is linked to breast carcinoma via a gene that it downregulates, which is in turn associated with the disease. One such intermediate gene exhibits a log2 fold change of -1.681 and an adjusted p-value of 0.02516 in peripheral blood mononuclear cells (study GSE131504). Which disease is connected to this specif... | viral hepatitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is linked to breast carcinoma via a gene that it downregulates, which is in turn associated with the disease. On... | |
medium_hidden_intermediate_10733 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene that participates in Nephrin family interactions. One such gene exhibited a log2 fold change of -1.138 and an adjusted p-value of 0.04167. Which protein is encoded by this specific... | Kin of IRRE-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10733","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_10734 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain genes that subsequently interact with RAB11A. One such gene exhibits a log2 fold change of approximately 2.63 and an adjusted p-value of approximately 3.93e-07. Which cellular component is this specific... | cell-cell junction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain genes ... | |
medium_hidden_intermediate_10735 | A specific genomic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that is enriched in conventional dendritic cells. Evidence for this gene in immune cell RNA-seq data reports a mean expression of 17.22 TPM, a z-score of 1.82, and a fold enrichment of 4.19. Which protein does this gene ... | MAP3K7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific genomic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that is enriched in conv... | |
medium_hidden_intermediate_10736 | Two genes are downregulated by Human immunodeficiency virus 1 and interact with BAG3. One of these genes exhibits a log2 fold change of -1.230 and an adjusted p-value of 0.01434 in macrophages (study GSE108897). Which disease is associated with genomic alterations in that specific gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and interact with BAG3. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_10737 | Human immunodeficiency virus 1 upregulates a gene that is located in the centrosome. Experimental data from a study on macrophages (GSE108897) indicates that this gene has a log2 fold change of 1.914 and an adjusted p-value of 1.299e-05. Which protein is encoded by this gene? | Fibronectin type III and SPRY domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the centrosome. Experimental data from a study on macro... | |
medium_hidden_intermediate_10740 | In a study of pancreatic cell lines (GSE151803), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which is involved in the negative regulation of the apoptotic process. This gene exhibited a log2 fold change of -1.720 and an adjusted p-value of 0.04504. Which protein is e... | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pancreatic cell lines (GSE151803), Severe acute respiratory syndrome-related coronavirus was found to downregu... | |
medium_hidden_intermediate_10741 | Pegivirus C downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.89 and an adjusted p-value of 0.006. Which protein is encoded by this s... | Kelch-like protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10741","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. ... | |
medium_hidden_intermediate_10742 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the nucleolus via a 'located in' relationship. One of these genes exhibits a log2 fold change of approximately -1.28 and an adjusted p-value of 0.008754 in a specific dataset. Which cell type is associated with... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10742","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the nucleolus ... | |
medium_hidden_intermediate_10743 | LMNA is linked to a specific gene via an 'interacts with' relationship, and this gene is subsequently linked to Naive CD4+ T cells via an 'enriched in' relationship. Evidence for one such gene states: 'In this study, we identify a novel interaction between lamin A/C and hsMOK2 by using the yeast two-hybrid system.' Whi... | Zinc finger protein 239 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10743","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"LMNA is linked to a specific gene via an 'interacts with' relationship, and this gene is subsequently linked to Naive CD4+ T... | |
medium_hidden_intermediate_10744 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin protein ligase binding. Transcriptomic data for this gene shows a log2 fold change of 4.181 and an adjusted p-value of 0.004049. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin protein ligase binding.... | |
medium_hidden_intermediate_10748 | Pegivirus C downregulates a specific gene, the product of which binds to HSP90AA1. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -2.399 and an adjusted p-value of 0.004127. What protein is encoded by this gene? | CLIP-associating protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, the product of which binds to HSP90AA1. In a study of peripheral blood mononuclea... | |
medium_hidden_intermediate_10749 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in protein refolding. One such gene exhibited a log2 fold change of approximately 2.56 and an adjusted p-value of approximately 6.50e-09. Which protein is encoded by this specific gene? | Stromal cell-derived factor 2-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10749","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_10750 | Human betaherpesvirus 5 downregulates a gene that interacts with STK4. In a study of foreskin fibroblast cell lines (GSE111036), this gene exhibited a log2 fold change of -1.933 and an adjusted p-value of 0.0288. Which disease is associated with this gene? | sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that interacts with STK4. In a study of foreskin fibroblast cell lines (GSE1110... | |
medium_hidden_intermediate_10751 | Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. Evidence for this specific gene reports a log2 fold change of 1.414 and an adjusted p-value of 0.005251. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. Evidence for this specific gene reports a log2 ... | |
medium_hidden_intermediate_10752 | Hepacivirus C upregulates multiple genes that are involved in the antibacterial humoral response. One such gene exhibits a log2 fold change of 2.584 and an adjusted p-value of 2.747e-05 in liver tissue data from study GSE12720. Which protein is encoded by this specific gene? | Defensin alpha 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10752","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates multiple genes that are involved in the antibacterial humoral response. One such gene exhibits a l... | |
medium_hidden_intermediate_10754 | A gene is downregulated by Pegivirus C and enriched in memory B cells. Evidence for this gene reports a log2 fold change of -1.681 and an adjusted p-value of 0.03229. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10754","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Pegivirus C and enriched in memory B cells. Evidence for this gene reports a log2 fold change of ... | |
medium_hidden_intermediate_10756 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables serine-type endopeptidase inhibitor activity. Evidence for one such gene reports a log2 fold change of 1.575 and an adjusted p-value of 0.009409. Which protein is encoded by that gene? | Serpin B7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables serine-type endopeptidase inhibitor ac... | |
medium_hidden_intermediate_10757 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn participates in nuclear events mediated by NFE2L2. This gene exhibited a log2 fold change of 3.451 and an adjusted p-value of 1.841e-10. Which protein is encoded by this gene? | Transaldolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_10758 | Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to malignant glioma via an association relationship. One of these genes exhibits a log2 fold change of -2.844 and an adjusted p-value of 0.03172 in macrophages (study GSE108897). Which protein is encoded by the gene matching th... | Kit ligand | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to malignant glioma via an asso... | |
medium_hidden_intermediate_10759 | In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with KAT2B. Evidence for this specific gene reports a log2 fold change of approximately 1.13 and an adjusted p-value of 2.33e-05. Which protein is encoded by this gene? | Homeobox protein Hox-B9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10759","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and i... | |
medium_hidden_intermediate_10762 | Cardiovirus A downregulates a gene that is located in the mitotic spindle. Evidence for this gene reports a log2 fold change of -1.610 and an adjusted p-value of 0.03058. Which protein is encoded by this gene? | Microtubule-associated protein 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is located in the mitotic spindle. Evidence for this gene reports a log2 fold change... | |
medium_hidden_intermediate_10767 | Human betaherpesvirus 5 is reported to upregulate a gene that participates in post-translational protein modification. In a study of foreskin fibroblast cell lines (GSE130665), one such gene exhibited a log2 fold change of approximately 1.227 and an adjusted p-value of 2.402e-06. Which protein is encoded by this specif... | Ras-related protein Rab-32 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that participates in post-translational protein modification. In a ... | |
medium_hidden_intermediate_10770 | Pegivirus C is reported to downregulate a specific gene that is involved in protein phosphorylation. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of approximately -1.612 and an adjusted p-value of 0.00588. Which protein does this gene inte... | MAPK8IP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in protein phosphorylation. Transcriptomic data fro... | |
medium_hidden_intermediate_10771 | Human immunodeficiency virus 1 downregulates a specific histone variant that participates in the assembly of the ORC complex at the origin of replication. In a study of macrophages (GSE108897), this entity exhibited a log2 fold change of -2.379 and an adjusted p-value of 0.03243. Which protein is encoded by this downre... | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific histone variant that participates in the assembly of the ORC complex... | |
medium_hidden_intermediate_10772 | Pegivirus C is reported to downregulate a gene that is involved in the immune response. Experimental data from a study on peripheral blood mononuclear cells indicates that this specific gene exhibits a log2 fold change of -2.235 and an adjusted p-value of 8.569e-05. Which protein is encoded by this gene? | Phosphoinositide 3-kinase regulatory subunit 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the immune response. Experimental data from a study on pe... | |
medium_hidden_intermediate_10773 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the lysosomal membrane. Evidence for this gene reports a log2 fold change of 1.373 and an adjusted p-value of 0.04621. Which protein does this gene product interact with? | VAPB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10773","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the lysosomal membrane. Evidence... | |
medium_hidden_intermediate_10775 | Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn associated with goiter. Experimental data for this gene in dendritic cells shows a log2 fold change of 1.068 and an adjusted p-value of 0.00119. Which protein is encoded by this gene? | Placenta growth factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn associated with goiter. Experimental dat... | |
medium_hidden_intermediate_10776 | An anatomical entity is defined as a bone that is part of the tarsal skeleton, with examples including the calcaneus, talus, and centralia. This entity is a type of tarsal bone, which in turn is a type of autopod bone. Which anatomical structure is this entity a part of? | skeleton of pes | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10776","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"An anatomical entity is defined as a bone that is part of the tarsal skeleton, with examples including the calcaneus, talus,... | |
medium_hidden_intermediate_10777 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and is involved in the positive regulation of canonical NF-kappaB signal transduction. This specific gene exhibits a log2 fold change of approximately -1.14 and an adjusted p-value of 0.001951. Which prot... | Mesoderm induction early response protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and is i... | |
medium_hidden_intermediate_10778 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to SRC via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.153 and an adjusted p-value of 0.04873. Which gene interacts with ... | RHCG | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_10780 | Human betaherpesvirus 5 is linked to leukemia via a gene that it downregulates and which is associated with the disease. One such gene exhibits a log2 fold change of -1.315 and an adjusted p-value of 0.04747 in foreskin fibroblast cell lines. Which protein is encoded by this specific gene? | Death-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to leukemia via a gene that it downregulates and which is associated with the disease. One... | |
medium_hidden_intermediate_10782 | Human betaherpesvirus 5 is known to downregulate certain genes that are enriched in basophils. One such gene exhibits a log2 fold change of -1.428 and an adjusted p-value of 9.134e-05 in foreskin fibroblast cell lines. What molecular function is enabled by this specific gene? | endopeptidase inhibitor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that are enriched in basophils. One such gene exhibits a log2... | |
medium_hidden_intermediate_10787 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in caveola. One of these genes exhibits a log2 fold change of approximately -1.014 and an adjusted p-value of 0.002098 in a specific study. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in caveola. One of thes... | |
medium_hidden_intermediate_10788 | Zika virus downregulates a specific gene, which is involved in the mitotic G2/M transition checkpoint. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -3.27 and an adjusted p-value of 0.01813. Which protein is encoded by this gene? | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is involved in the mitotic G2/M transition checkpoint. In a study of glioma ... | |
medium_hidden_intermediate_10789 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain genes that participate in post-translational protein modification. One such gene exhibited a log2 fold change of -2.009 and an adjusted p-value of 0.01509. Which protein is encoded by this specific ge... | Spondin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10789","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain gene... | |
medium_hidden_intermediate_10790 | Cyclosporine interacts with a specific drug, which in turn interacts with Nitrous acid. Evidence indicates that this specific drug is one of twelve medications (including sertraline, losartan, quinine, atorvastatin, simvastatin, pravastatin, fluvastatin, alendronate, digoxin, acyclovir, and oxycodone) identified as hav... | heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cyclosporine interacts with a specific drug, which in turn interacts with Nitrous acid. Evidence indicates that this specifi... | |
medium_hidden_intermediate_10791 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and located in the focal adhesion. This gene exhibits a log2 fold change of 3.038 and an adjusted p-value of 0.0008939. Which protein does this gene product bind to? | RBSN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and located in the focal adhe... | |
medium_hidden_intermediate_10792 | Enterovirus A upregulates a gene that participates in the regulation of endogenous retroelements by KRAB-ZFP proteins. Evidence for one such gene reports a log2 fold change of 1.027 and an adjusted p-value of 0.005866. Which protein is encoded by that gene? | Zinc finger protein 649 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that participates in the regulation of endogenous retroelements by KRAB-ZFP proteins. Evide... | |
medium_hidden_intermediate_10793 | A gene serves as a marker for Natural killer cells and is enriched in Memory CD8+ T cells. Evidence for this gene includes a mean expression of 19.20 TPM, a z-score of 1.54, and a fold enrichment of 3.75. Which disease is associated with this gene? | preeclampsia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Natural killer cells and is enriched in Memory CD8+ T cells. Evidence for this gene includes a... | |
medium_hidden_intermediate_10795 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with MAGI1. One of these genes was reported in a study on cardiomyocyte cell lines (GSE162736) with a log2 fold change of approximately 1.387 and an adjusted p-value of 0.00199. Which protein is encoded by this specific gene... | Vang-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with MAGI1. One of these gen... | |
medium_hidden_intermediate_10796 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hyperplasia. One of these genes exhibits a log2 fold change of 2.886 and an adjusted p-value of 0.0008942 in choroid plexus epithelium. Which disease is linked to this specific gene through genomic alterations? | myeloproliferative disorder, chronic, with eosinophilia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10796","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hyperplasia. One ... | |
medium_hidden_intermediate_10797 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with HIST2H2BE. Evidence for this gene reports a log2 fold change of 1.081 and an adjusted p-value of 0.03851. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10797","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with HIST2H2BE. Evidence for th... |
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