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medium_convergence_02970 | DNAH2 and DNAH7 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that the associated entity is an inner arm component of human cilia that is synthesized but not assembled in a case of Primary Ciliary Dyskinesia (PCD). Which biological process is c... | axonemal dynein complex assembly | Medium | convergence | {"qa_id":"medium_convergence_02970","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAH2 and DNAH7 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that the associated... | |
medium_convergence_02971 | NUB1 and PSMA1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A yeast two-hybrid screen identified NEDD8 ultimate buster-1L as a non-covalent binding partner of the protein encoded by this entity, and this interaction was confirmed by coimmunoprecipitation and g... | Ubiquitin D | Medium | convergence | {"qa_id":"medium_convergence_02971","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUB1 and PSMA1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A yeast two-hybrid screen identified ... | |
medium_convergence_02973 | CLDN3 and CLDN19 are both associated with multiple shared biological processes. One specific shared process is supported by evidence stating that mutated claudin-19 affects multiple stages of RPE and retinal differentiation through its effects on multiple functions of the RPE. Which biological process is this shared en... | epithelium development | Medium | convergence | {"qa_id":"medium_convergence_02973","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLDN3 and CLDN19 are both associated with multiple shared biological processes. One specific shared process is supported by evidence stating that mutated cla... | |
medium_convergence_02974 | CCDC22 and ARNT each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We have previously shown that the C-terminal PAS domains of an HIF-alpha isoform (HIF-2alpha) and ARNT interact in vitro, and that mutations in the solvent-exposed beta-sheet surface of the HIF-2alpha d... | transcription regulator complex | Medium | convergence | {"qa_id":"medium_convergence_02974","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and ARNT each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We have previously shown that the C-ter... | |
medium_convergence_02975 | NEDD8 and PSMA3 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared p... | Proteasome subunit alpha type-4 | Medium | convergence | {"qa_id":"medium_convergence_02975","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD8 and PSMA3 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20... | |
medium_convergence_02976 | Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately -1.024 and an adjusted p-value of 0.0002148. Which disease is associated with this gene through genomic alterati... | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_02976","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE1... | |
medium_convergence_02978 | CHEK2 and BRCA1 share multiple protein-binding partners. One of these shared partners contains a COOH-terminal HECT domain that interacts with an NH(2)-terminal degron domain in BRCA1. Which disease is associated with this specific shared partner via a biomarker relationship? | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_02978","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and BRCA1 share multiple protein-binding partners. One of these shared partners contains a COOH-terminal HECT domain that interacts with an NH(2)-termi... | |
medium_convergence_02979 | Both Human betaherpesvirus 5 and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE132081) show a log2 fold change of approximately -2.34 and an adjusted p-value of 0.0012. Which biological process is this gene involved in? | visual perception | Medium | convergence | {"qa_id":"medium_convergence_02979","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Zaire ebolavirus are known to downregulate a specific host gene. Experimental data for this gene in foreskin fibroblast cell... | |
medium_convergence_02980 | Both Influenza A virus and Human mastadenovirus C are known to upregulate the expression of a specific gene. Experimental data from a study on non-small cell lung adenocarcinoma cell lines (GSE106279) indicates that for one such shared target, the log2 fold change is approximately 2.54 and the adjusted p-value is 0.002... | TNF receptor-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_02980","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Human mastadenovirus C are known to upregulate the expression of a specific gene. Experimental data from a study on non-small cell... | |
medium_convergence_02981 | NEDD8 and PSMA2 both interact with a shared protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared partner? | Proteasome subunit alpha type-4 | Medium | convergence | {"qa_id":"medium_convergence_02981","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD8 and PSMA2 both interact with a shared protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_02982 | GNA11 and GNAI2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In vitro binding assays reveal that this protein and RGS16 bind to Galphai and Galphao subunits of heterotrimeric G-proteins, but not to Galphas.' Which protein is encoded by that shared partner... | Regulator of G-protein signaling 5 | Medium | convergence | {"qa_id":"medium_convergence_02982","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA11 and GNAI2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In vitro binding assays reveal ... | |
medium_convergence_02983 | Both West Nile virus and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Experimental data for this gene in monocyte-derived dendritic cells (from study GSE136342) reports a log2 fold change of approximately 1.347 and an adjusted p-value of 0.0004016. Which protein is encoded by this g... | Protein EVI2A | Medium | convergence | {"qa_id":"medium_convergence_02983","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Experimental data for this gene in monocyte-derive... | |
medium_convergence_02985 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.19 and an adjusted p-value of approximately 0.03. Which disease is associated with this gene as a biomarker? | malaria | Medium | convergence | {"qa_id":"medium_convergence_02985","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.19 and an adju... | |
medium_convergence_02986 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold change of approximately -1.042 and an adjusted p-value of 0.0002836. Which disease is linked to this gene via genomic alterations? | Miller-Dieker lissencephaly syndrome | Medium | convergence | {"qa_id":"medium_convergence_02986","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold... | |
medium_convergence_02987 | EGFR and CBL share multiple binding partners. One such shared partner directly associates with c-Cbl, a known down-regulator of RTK signaling. Which disease is connected to this specific shared partner through genomic alterations? | Metaphyseal chondrodysplasia, McKusick type | Medium | convergence | {"qa_id":"medium_convergence_02987","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and CBL share multiple binding partners. One such shared partner directly associates with c-Cbl, a known down-regulator of RTK signaling. Which disease ... | |
medium_convergence_02988 | Human respirovirus 3 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.012 and an adjusted p-value of 0.04933. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02988","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell ... | |
medium_convergence_02989 | Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of -1.601 and an adjusted p-value of 0.001774. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02989","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports... | |
medium_convergence_02990 | ESR1 and MCM7 share a common interacting partner. Evidence indicates that the protein product of this shared partner interacts with the activation function 2 domain of the Estrogen Receptor (ER) and colocalizes with ER in activated cells. Which protein is encoded by this shared interacting partner? | CDK-activating kinase assembly factor MAT1 | Medium | convergence | {"qa_id":"medium_convergence_02990","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and MCM7 share a common interacting partner. Evidence indicates that the protein product of this shared partner interacts with the activation function 2... | |
medium_convergence_02991 | CDKN1A and AGR2 share a common interacting partner. Evidence indicates that one such shared entity binds to p21, MDM2, and the C8 subunit of the 20S proteasome during the G1 phase, thereby facilitating the proteasomal targeting of p21. Which protein is encoded by this shared interacting partner? | 14-3-3 protein theta | Medium | convergence | {"qa_id":"medium_convergence_02991","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and AGR2 share a common interacting partner. Evidence indicates that one such shared entity binds to p21, MDM2, and the C8 subunit of the 20S proteaso... | |
medium_convergence_02992 | CFTR and EGFR share common interacting partners. One such partner is a protein that interacts with the intracellular domain of EGFR and mediates EGF-dependent activation of phospholipase D2 (PLD2), but does not mediate the activation of PLD1. Which gene encodes this specific protein? | ADP-ribosylation factor 4 | Medium | convergence | {"qa_id":"medium_convergence_02992","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and EGFR share common interacting partners. One such partner is a protein that interacts with the intracellular domain of EGFR and mediates EGF-dependen... | |
medium_convergence_02993 | Calcitriol (topical) and Erythromycin share a common drug interaction partner. Evidence regarding this shared partner notes that 'Currently, the orally administered erythromycin, clarithromycin, and roxithromycin have been implicated.' Which disease is this shared partner indicated for? | heart failure | Medium | convergence | {"qa_id":"medium_convergence_02993","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Calcitriol (topical) and Erythromycin share a common drug interaction partner. Evidence regarding this shared partner notes that 'Currently, the orally admin... | |
medium_convergence_02994 | CRK and CD2AP both interact with a specific shared protein. Evidence indicates that this shared protein associates in vitro with the SH3 domains of Src family members and with the Crk adapter protein. Which protein is encoded by the gene corresponding to this shared entity? | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02994","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and CD2AP both interact with a specific shared protein. Evidence indicates that this shared protein associates in vitro with the SH3 domains of Src famil... | |
medium_convergence_02995 | Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from bronchial epithelial cells, reports a log2 fold change of approximately 1.039 and an adjusted p-value of 0.00151. Which protein interacts with this gene product? | TPT1 | Medium | convergence | {"qa_id":"medium_convergence_02995","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from bronchial epi... | |
medium_convergence_02996 | CHD3 and XRCC6 share multiple interacting partners. One such shared partner is described in a study stating: 'Herein, we report that this protein is a novel Ku70-interacting protein identified by yeast two-hybrid screening.' Which protein is encoded by this specific shared partner? | DNA mismatch repair protein Msh6 | Medium | convergence | {"qa_id":"medium_convergence_02996","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and XRCC6 share multiple interacting partners. One such shared partner is described in a study stating: 'Herein, we report that this protein is a novel ... | |
medium_convergence_02997 | Both the androgen receptor (AR) and RNA polymerase II subunit A (POLR2A) interact with a common protein partner. Experimental evidence indicates that Yeast two-hybrid and glutathione S-transferase pull-down assays demonstrate that both the N- and C-termini of a specific protein isoform interact with the DNA- and ligand... | Histone-lysine N-methyltransferase, H3 lysine-36 specific | Medium | convergence | {"qa_id":"medium_convergence_02997","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and RNA polymerase II subunit A (POLR2A) interact with a common protein partner. Experimental evidence indicates that Yeast t... | |
medium_convergence_02998 | CENPA and CENPH each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which disease is associated with this protein? | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_02998","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPH each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_02999 | CDK2 and CCNE2 share multiple binding partners. One shared partner is described by the evidence: 'The cyclin dependent kinase inhibitor (CKI) [ENTITY] binds to cyclin E/CDK2 complexes and prevents premature S-phase entry.' Which protein is encoded by the gene corresponding to this shared entity? | Cyclin-dependent kinase inhibitor 1B | Medium | convergence | {"qa_id":"medium_convergence_02999","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CCNE2 share multiple binding partners. One shared partner is described by the evidence: 'The cyclin dependent kinase inhibitor (CKI) [ENTITY] binds ... | |
medium_convergence_03000 | BRCA1 and UBA52 share common binding partners. One such partner is implicated in a study stating: 'By using NMR spectroscopy and site-directed mutagenesis, we have mapped the binding site on the BRCA1-BARD1 heterodimer for the Ub-conjugating enzyme UbcH5c.' Which disease is associated with this specific shared partner ... | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_03000","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and UBA52 share common binding partners. One such partner is implicated in a study stating: 'By using NMR spectroscopy and site-directed mutagenesis, w... | |
medium_convergence_03002 | CDC37 and IKBKB each interact with more than one shared gene product. Evidence concerning one shared entity reports that monoubiquitylated PKCε interacts with a ubiquitin-binding domain in NEMO zinc finger and recruits the cytosolic IKK complex to the plasma membrane, where PKCε phosphorylates IKKβ at Ser177 and activa... | Protein kinase C epsilon type | Medium | convergence | {"qa_id":"medium_convergence_03002","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and IKBKB each interact with more than one shared gene product. Evidence concerning one shared entity reports that monoubiquitylated PKCε interacts wit... | |
medium_convergence_03003 | HSP90AA1 and HSP90AB1 both interact with a shared protein. Evidence indicates that this specific shared entity is a client protein of Hsp90 in vivo. Which disease is associated with this entity via a biomarker relationship? | myelofibrosis | Medium | convergence | {"qa_id":"medium_convergence_03003","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and HSP90AB1 both interact with a shared protein. Evidence indicates that this specific shared entity is a client protein of Hsp90 in vivo. Which di... | |
medium_convergence_03005 | LILRB1 and FOXP3 are both associated with a shared biological process. Evidence regarding one of the entities involved in this process indicates that transduced T cells exhibited impaired proliferation and reduced production of cytokines, including IL-2 and IL-10, upon TCR stimulation. These cells also up-regulated reg... | T cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_03005","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LILRB1 and FOXP3 are both associated with a shared biological process. Evidence regarding one of the entities involved in this process indicates that transdu... | |
medium_convergence_03006 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of -1.953 and an adjusted p-value of 0.001434. Which cell type is this gene enriched in? | naive B cell | Medium | convergence | {"qa_id":"medium_convergence_03006","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) repo... | |
medium_convergence_03007 | SMAD1 and BMPR2 both interact with a specific shared protein. Evidence indicates that this protein specifically competes with Smad4 for binding to receptor-activated Smad1, resulting in an apparently inactive Smad1-protein complex. Which gene encodes this protein? | SMAD family member 6 | Medium | convergence | {"qa_id":"medium_convergence_03007","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and BMPR2 both interact with a specific shared protein. Evidence indicates that this protein specifically competes with Smad4 for binding to receptor-a... | |
medium_convergence_03008 | MCM10 and CDT1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that HsMcm10 is associated with the human protein corresponding to that entity when overexpressed in COS-1 cells. Which protein is encoded by that entity? | Origin recognition complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_03008","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM10 and CDT1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that HsMcm10 is associated with the hum... | |
medium_convergence_03009 | CREBBP and EP300 both interact with a specific transcription factor. Evidence regarding this interaction states: 'We show here that the transcriptional co-activators CBP/p300 bind to and control the activity of the inducible N-terminal transactivation domain of this transcription factor, TAD-A.' Which protein is encode... | Nuclear factor of activated T-cells, cytoplasmic 1 | Medium | convergence | {"qa_id":"medium_convergence_03009","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EP300 both interact with a specific transcription factor. Evidence regarding this interaction states: 'We show here that the transcriptional co-ac... | |
medium_convergence_03010 | Vaccinia virus and Dengue virus both upregulate a specific gene in cervical adenocarcinoma cells (study GSE11238). For one such shared target, the reported log2 fold change is 1.652 and the adjusted p-value is 4.258e-06. Which protein is encoded by this gene? | GPI alpha-1,4-mannosyltransferase I, stabilizing subunit | Medium | convergence | {"qa_id":"medium_convergence_03010","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene in cervical adenocarcinoma cells (study GSE11238). For one such shared target, the reported l... | |
medium_convergence_03011 | Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.213 and an adjusted p-value of approximately 7.909e-05. Which biological process is this gene involved in? | proteasome core complex assembly | Medium | convergence | {"qa_id":"medium_convergence_03011","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) repo... | |
medium_convergence_03012 | PARP1 and DNMT3B share common interaction partners. One such shared partner is reported to co-purify and interact, both in vivo and in vitro, with several components of the condensin complex (specifically hCAP-C, hCAP-E, and a third subunit) as well as KIF4A. Which protein is encoded by the gene corresponding to this s... | Condensin complex subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_03012","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and DNMT3B share common interaction partners. One such shared partner is reported to co-purify and interact, both in vivo and in vitro, with several co... | |
medium_convergence_03013 | ARRB1 and GNG2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Immunoprecipitation experiments demonstrated that beta-arrestin 1 physically interacts with delta opioid receptor (DOR) co-expressed in human embryonic kidney 293 cells in an agonist-enhanced manner and trunc... | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03013","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB1 and GNG2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Immunoprecipitation experiments demonstrated ... | |
medium_convergence_03014 | ACTG1 and WAS both interact with a shared protein partner. Evidence indicates that a specific protein binds to the WH1 domain of WASP and N-WASP. Which protein, encoded by the gene corresponding to this shared partner, is the target of the 'encodes' relationship? | WAS/WASL-interacting protein family member 2 | Medium | convergence | {"qa_id":"medium_convergence_03014","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTG1 and WAS both interact with a shared protein partner. Evidence indicates that a specific protein binds to the WH1 domain of WASP and N-WASP. Which prote... | |
medium_convergence_03015 | PXN and STK4 share multiple interacting partners. One such partner is supported by evidence stating: 'Cell-free interaction assay with immobilized paxillin shows that TG-2 bind to paxillin directly.' Which protein is encoded by this specific interacting partner? | Protein-glutamine gamma-glutamyltransferase 2 | Medium | convergence | {"qa_id":"medium_convergence_03015","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PXN and STK4 share multiple interacting partners. One such partner is supported by evidence stating: 'Cell-free interaction assay with immobilized paxillin s... | |
medium_convergence_03016 | ACTR2 and AMPH both interact with a specific protein complex subunit. Evidence regarding this shared partner states: 'They interact with dynamin and synaptojanin via their COOH-terminal SH3 domain, whereas their central regions contain binding sites for clathrin and for the clathrin adaptor AP-2.' Which protein is enco... | AP-2 complex subunit beta | Medium | convergence | {"qa_id":"medium_convergence_03016","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR2 and AMPH both interact with a specific protein complex subunit. Evidence regarding this shared partner states: 'They interact with dynamin and synaptoj... | |
medium_convergence_03017 | BLM and BRCA1 both interact with a specific protein. Evidence regarding this protein states: 'Here, we report that purified BLM and human [protein] interact in vitro and in vivo, and that residues in the N- and C-terminal domains of BLM can independently mediate this interaction.' Which disease is associated with this ... | uveal melanoma | Medium | convergence | {"qa_id":"medium_convergence_03017","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BLM and BRCA1 both interact with a specific protein. Evidence regarding this protein states: 'Here, we report that purified BLM and human [protein] interact ... | |
medium_convergence_03018 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of -1.023 and an adjusted p-value of 1.03e-05. Which protein is encoded by this gene? | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase | Medium | convergence | {"qa_id":"medium_convergence_03018","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports... | |
medium_convergence_03019 | LRRK2 and DVL1 share common interaction partners. One such shared partner is described in evidence stating: 'We report the interaction of LRRK2 with the dishevelled family of phosphoproteins (DVL1-3), key regulators of Wnt (Wingless/Int) signalling pathways important for axon guidance, synapse formation and neuronal ma... | Segment polarity protein dishevelled homolog DVL-2 | Medium | convergence | {"qa_id":"medium_convergence_03019","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRRK2 and DVL1 share common interaction partners. One such shared partner is described in evidence stating: 'We report the interaction of LRRK2 with the dish... | |
medium_convergence_03020 | AP2M1 and CLTC both interact with a shared protein. Evidence regarding this shared protein states: 'The interaction with clathrin is direct and not mediated by epsin-bound AP-2.' Which protein is encoded by the gene corresponding to this shared entity? | Epsin-1 | Medium | convergence | {"qa_id":"medium_convergence_03020","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2M1 and CLTC both interact with a shared protein. Evidence regarding this shared protein states: 'The interaction with clathrin is direct and not mediated ... | |
medium_convergence_03021 | Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. In a study of gamma delta T-lymphocytes (GSE13906), this gene exhibited a log2 fold change of approximately -1.65 and an adjusted p-value of approximately 0.021. Which biological process is... | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_03021","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. In a study of gamma delta ... | |
medium_convergence_03023 | EP300 and POU5F1 share multiple protein interaction partners. One such shared partner is implicated in a study where p300, the partner protein, and endogenous CITED2 were co-immunoprecipitated from transfected U2-OS cells, demonstrating physical interaction in vivo. Which protein product is encoded by this specific sha... | Transcription factor AP-2-alpha | Medium | convergence | {"qa_id":"medium_convergence_03023","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and POU5F1 share multiple protein interaction partners. One such shared partner is implicated in a study where p300, the partner protein, and endogenou... | |
medium_convergence_03024 | PCBD1 and HNF1A share a common interaction partner. Evidence regarding one such partner states: 'We report the initial characterization of HNF-1 beta, which is closely related to HNF-1 alpha and is able to form heterodimers with HNF-1 alpha in vitro.' Which cellular component is this specific entity located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_03024","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCBD1 and HNF1A share a common interaction partner. Evidence regarding one such partner states: 'We report the initial characterization of HNF-1 beta, which ... | |
medium_convergence_03025 | Both Measles morbillivirus and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) show a log2 fold change of approximately 1.549 and an adjusted p-value of approximately 0.000489. What protein is encoded by this gene? | Exosome complex component RRP45 | Medium | convergence | {"qa_id":"medium_convergence_03025","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (from s... | |
medium_convergence_03026 | IFNG and IL12B are both involved in a shared biological process. Evidence concerning one such shared entity states: 'These results further establish IFNgamma as a primary modulator of IL-17 production in the human cells, much as in the murine system.' Which biological process is connected to that entity through the rel... | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_03026","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFNG and IL12B are both involved in a shared biological process. Evidence concerning one such shared entity states: 'These results further establish IFNgamma... | |
medium_convergence_03027 | CDC37 and HSP90AA1 both interact with a shared protein. Evidence regarding this shared entity states: 'In this study, we show that the Hsp90 co-chaperone [shared entity] bound preferentially to the beta isoform of Hsp90 in vitro.' Which protein is encoded by this shared entity? | Protein unc-45 homolog A | Medium | convergence | {"qa_id":"medium_convergence_03027","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and HSP90AA1 both interact with a shared protein. Evidence regarding this shared entity states: 'In this study, we show that the Hsp90 co-chaperone [sh... | |
medium_convergence_03028 | Amikacin and Gentamicin both interact with a specific shared drug. Evidence regarding this shared drug states: 'In combination with gentamicin, synergy or addition was observed in 94% of 35 strains tested by the chequerboard technique.' Which drug does this shared entity interact with? | Picosulfuric acid | Medium | convergence | {"qa_id":"medium_convergence_03028","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amikacin and Gentamicin both interact with a specific shared drug. Evidence regarding this shared drug states: 'In combination with gentamicin, synergy or ad... | |
medium_convergence_03029 | HLA-DQB2 and CD247 share a common interaction partner. Evidence regarding this shared entity states: 'In CD45-negative T cells, p70zap was constitutively phosphorylated on tyrosine and co-immunoprecipitated with the TcR-zeta chain.' Which protein is encoded by this shared entity? | Tyrosine-protein kinase ZAP-70 | Medium | convergence | {"qa_id":"medium_convergence_03029","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-DQB2 and CD247 share a common interaction partner. Evidence regarding this shared entity states: 'In CD45-negative T cells, p70zap was constitutively pho... | |
medium_convergence_03030 | DLG3 and GRIN2B both interact with a specific protein that functions as a Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor. Experimental evidence indicates that the NR2B subunit of the NMDAR, but not the NR2A or NR1 subunits, interacts with this protein both in vivo and in vitro. Which disease is the... | drug-induced dyskinesia | Medium | convergence | {"qa_id":"medium_convergence_03030","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and GRIN2B both interact with a specific protein that functions as a Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor. Experimental e... | |
medium_convergence_03031 | EP400 and KMT2D both interact with a shared protein. Evidence indicates that this shared protein associates with histone-modifying enzymatic complexes, specifically the MLL2 histone methyltransferase (HMT) and STAGA histone acetyltransferase (HAT) complexes, to facilitate their interaction with β-catenin and to augment... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03031","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP400 and KMT2D both interact with a shared protein. Evidence indicates that this shared protein associates with histone-modifying enzymatic complexes, speci... | |
medium_convergence_03033 | FCGR2B and FOXP3 are both involved in more than one shared biological process. One shared process is supported by evidence stating: 'The inhibitory receptor FcγRIIB plays a central role in regulating the generation of autoantibodies and their effector functions, which include activation of innate immune cells and the c... | immune response | Medium | convergence | {"qa_id":"medium_convergence_03033","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FCGR2B and FOXP3 are both involved in more than one shared biological process. One shared process is supported by evidence stating: 'The inhibitory receptor ... | |
medium_convergence_03034 | Both Hepacivirus C and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE119117, reports a log2 fold change of approximately 1.425 and an adjusted p-value of 0.02967. Which disease is associated with this g... | retinal degeneration | Medium | convergence | {"qa_id":"medium_convergence_03034","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene, derived from peripheral blood ... | |
medium_convergence_03036 | Both Human orthopneumovirus and Influenza A virus are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes reports a log2 fold change of approximately 1.356 and an adjusted p-value of 0.03658. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03036","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Influenza A virus are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes ... | |
medium_convergence_03037 | CDK2 and TOPBP1 share a common interaction partner. Evidence indicates that this shared entity associates with Cyclin A (specifically in the context of Cyclin A-cdk2 complexes) both in vitro and in vivo. Which disease is associated with this shared entity? | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_03037","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and TOPBP1 share a common interaction partner. Evidence indicates that this shared entity associates with Cyclin A (specifically in the context of Cycli... | |
medium_convergence_03038 | PSMA1 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared partner? | Proteasome subunit alpha type-5 | Medium | convergence | {"qa_id":"medium_convergence_03038","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA1 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_03039 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene has a log2 fold change of approximately -1.24 and an adjusted p-value of approximately 0.0107. Which cellular component is this gene locat... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_03039","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data from a study on macrophages (GSE108897) ... | |
medium_convergence_03040 | FANCE and CENPS each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and this shared partner but not with FANCD2.' Which protein is encoded by the gene corresponding to that shared p... | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_03040","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and CENPS each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged FANC... | |
medium_convergence_03041 | RC3H1 and AKT1 share multiple interacting partners. One such shared partner has been shown to interact with AKT1 using confocal imaging, co-immunoprecipitation (Co-IP), and GST pulldown assays. Which protein is encoded by this specific shared partner? | RNA-binding protein FUS | Medium | convergence | {"qa_id":"medium_convergence_03041","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RC3H1 and AKT1 share multiple interacting partners. One such shared partner has been shown to interact with AKT1 using confocal imaging, co-immunoprecipitati... | |
medium_convergence_03042 | GNAI2 and GNAQ each interact with more than one shared protein. Evidence concerning one shared entity reports that WDR36 co-immunoprecipitated with Gαq and promoted the TPβ-Gαq interaction. Which disease is connected to that entity through a therapeutic relationship? | kidney failure | Medium | convergence | {"qa_id":"medium_convergence_03042","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI2 and GNAQ each interact with more than one shared protein. Evidence concerning one shared entity reports that WDR36 co-immunoprecipitated with Gαq and p... | |
medium_convergence_03043 | UBA52 and RBX1 both interact with a specific shared protein. Evidence indicates that this protein specifically interacts with endogenous Cul2 in mammalian cells, whereas SOCS-box proteins associate with Cul5-Rbx2. Which protein is encoded by the gene corresponding to this shared entity? | von Hippel-Lindau disease tumor suppressor | Medium | convergence | {"qa_id":"medium_convergence_03043","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBA52 and RBX1 both interact with a specific shared protein. Evidence indicates that this protein specifically interacts with endogenous Cul2 in mammalian ce... | |
medium_convergence_03044 | ADRM1 and TMEM31 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We solved the structure of two such receptors with their preferred shuttle factor, namely hRpn13(Pru):hPLIC2(UBL) and scRpn1 T1:scRad23(UBL).' Which protein is encoded by the gene corresponding to this sh... | Ubiquilin-2 | Medium | convergence | {"qa_id":"medium_convergence_03044","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and TMEM31 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We solved the structure of two such recep... | |
medium_convergence_03045 | Cardiovirus A and Zika virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of approximately 1.69 and an adjusted p-value of approximately 0.011. Which biological process is this gene involved in? | ectoderm development | Medium | convergence | {"qa_id":"medium_convergence_03045","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zika virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of ap... | |
medium_convergence_03046 | DAXX and ASF1B both interact with a specific shared histone protein. Evidence indicates that the histone-binding domain of DAXX binds an H3.3-H4 heterodimer, making extensive contacts with both H3.3 and H4. Which disease is associated with this shared histone protein via a biomarker relationship? | childhood oligodendroglioma | Medium | convergence | {"qa_id":"medium_convergence_03046","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and ASF1B both interact with a specific shared histone protein. Evidence indicates that the histone-binding domain of DAXX binds an H3.3-H4 heterodimer,... | |
medium_convergence_03047 | LEF1 and HDAC8 both interact with a shared protein. Evidence regarding this shared protein states: 'We show that TLE/Gro interacts with LEF-1 and Pan, and inhibits LEF-1:beta-catenin-dependent transcription.' Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03047","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEF1 and HDAC8 both interact with a shared protein. Evidence regarding this shared protein states: 'We show that TLE/Gro interacts with LEF-1 and Pan, and in... | |
medium_convergence_03048 | BMP2 and ACVR2A both interact with a specific receptor protein. Evidence regarding this interaction states: 'We have used BMP-2 as a key representative of the BMPs to identify the epitopes for type I and type II receptor binding by mutational interaction analyses and have solved the crystal structure of a BMP2:BMPR-IA ... | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_03048","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and ACVR2A both interact with a specific receptor protein. Evidence regarding this interaction states: 'We have used BMP-2 as a key representative of th... | |
medium_convergence_03049 | COPB1 and CAPZB share a common binding partner. Evidence regarding this shared partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which protein is encoded by the gene corresponding to... | Coatomer subunit gamma-1 | Medium | convergence | {"qa_id":"medium_convergence_03049","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and CAPZB share a common binding partner. Evidence regarding this shared partner states: 'Herein we describe isolation of a subcomplex of coatomer cons... | |
medium_convergence_03050 | BIRC2 and MAP3K3 both interact with a shared protein partner. Evidence regarding one such partner states: 'Interestingly, we also find that the protein encoded by MAP3K7 and MEKK3 form a functional complex, in which the protein encoded by MAP3K7 regulates autophosphorylation of MEKK3.' Which protein is encoded by the g... | Mitogen-activated protein kinase kinase kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_03050","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and MAP3K3 both interact with a shared protein partner. Evidence regarding one such partner states: 'Interestingly, we also find that the protein encod... | |
medium_convergence_03051 | SMG1 and TTI2 both interact with a common protein. Experimental evidence regarding this shared partner indicates that it binds to the HEAT repeat segments of ATM and mTOR. Which protein is encoded by the gene corresponding to this shared partner? | Telomere length regulation protein TEL2 homolog | Medium | convergence | {"qa_id":"medium_convergence_03051","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and TTI2 both interact with a common protein. Experimental evidence regarding this shared partner indicates that it binds to the HEAT repeat segments of... | |
medium_convergence_03052 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately -2.34 and an adjusted p-value of... | GTP-binding protein Di-Ras3 | Medium | convergence | {"qa_id":"medium_convergence_03052","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental... | |
medium_convergence_03053 | CAND1 and CUL1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The evolutionarily conserved protein [ENTITY] acts as a substrate receptor for the SKP1-cullin-1-RBX1 ubiquitin ligase.' Which protein is encoded by that entity? | F-box only protein 9 | Medium | convergence | {"qa_id":"medium_convergence_03053","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The evolutionarily conserve... | |
medium_convergence_03054 | Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 4.698 and an adjusted p-value of 0.02952. Which cell type is this gene enriched in? | memory B cell | Medium | convergence | {"qa_id":"medium_convergence_03054","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of ... | |
medium_convergence_03055 | LAMTOR2 and ATG101 both interact with a common protein partner. Evidence regarding this shared partner states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 as an interacti... | Ragulator complex protein LAMTOR3 | Medium | convergence | {"qa_id":"medium_convergence_03055","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and ATG101 both interact with a common protein partner. Evidence regarding this shared partner states: 'In a two-hybrid screen with p14 as a bait, we... | |
medium_convergence_03056 | AP2M1 and FBXW11 both interact with a specific shared protein. Evidence indicates that for this shared protein, the integrity of two Serine residues at positions 535 and 539 within a specific destruction motif in its cytoplasmic tail is essential for recruiting beta-Trcp and undergoing efficient ubiquitination and degr... | Interferon alpha/beta receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_03056","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2M1 and FBXW11 both interact with a specific shared protein. Evidence indicates that for this shared protein, the integrity of two Serine residues at posit... | |
medium_convergence_03057 | Both Orthohepevirus A and Zika virus have been shown to upregulate a specific gene in hepatocytes. Experimental data from study GSE135619 indicates that for one such shared target, the log2 fold change is approximately 1.342 and the adjusted p-value is 0.03654. Which protein is encoded by this gene? | Histone-lysine N-methyltransferase 2C | Medium | convergence | {"qa_id":"medium_convergence_03057","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus have been shown to upregulate a specific gene in hepatocytes. Experimental data from study GSE135619 indicates that for ... | |
medium_convergence_03059 | RC3H1 and RNF219 share common interaction partners. One such shared partner is described in evidence stating: 'We demonstrate that RNF219 is an active RING-type E3 ligase which stably associates with CCR4-NOT via NOT9 through a short linear motif (SLiM) embedded within the C-terminal low-complexity region of RNF219.' W... | KIAA0232 | Medium | convergence | {"qa_id":"medium_convergence_03059","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RC3H1 and RNF219 share common interaction partners. One such shared partner is described in evidence stating: 'We demonstrate that RNF219 is an active RING-t... | |
medium_convergence_03060 | BRCA1 and FAM175A share common binding partners. One such shared partner contains a COOH-terminal HECT-containing domain that interacts with an NH(2)-terminal degron domain in BRCA1. Which cell type is enriched with this specific shared partner? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03060","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and FAM175A share common binding partners. One such shared partner contains a COOH-terminal HECT-containing domain that interacts with an NH(2)-termina... | |
medium_convergence_03062 | SMAD7 and RPS27A each interact with more than one shared protein. Evidence concerning one shared entity reports that coimmunoprecipitation demonstrated that this entity interacted with TβRI and SMAD7, which increased TβRI and SMAD7 ubiquitin levels. Which protein is connected to that entity through encodes? | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_03062","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and RPS27A each interact with more than one shared protein. Evidence concerning one shared entity reports that coimmunoprecipitation demonstrated that ... | |
medium_convergence_03063 | GNA13 and GNAI2 both interact with a specific receptor. Experimental evidence indicates that purification of TXA2 receptors using ligand (SQ31,491)-affinity chromatography resulted in the co-purification of a member of the G12 family (specifically Galpha13). Which disease is associated with this receptor as a biomarker... | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03063","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA13 and GNAI2 both interact with a specific receptor. Experimental evidence indicates that purification of TXA2 receptors using ligand (SQ31,491)-affinity ... | |
medium_convergence_03065 | YAP1 and RUVBL2 share multiple interaction partners. One such shared partner is implicated in enhancing CTGF expression through histone methylation. Which protein is encoded by this specific shared partner? | WD repeat-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_03065","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and RUVBL2 share multiple interaction partners. One such shared partner is implicated in enhancing CTGF expression through histone methylation. Which pr... | |
medium_convergence_03066 | Fluconazole and Dexbrompheniramine both interact with a specific drug. Pharmacokinetic evidence regarding this drug states that 'The increases in the AUC of a substrate associated with coadministration of an inhibitor were estimated using the equation 1/(1 - CR(CYP3A4) x IR(CYP3A4)), based on pharmacokinetic considerat... | anxiety | Medium | convergence | {"qa_id":"medium_convergence_03066","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluconazole and Dexbrompheniramine both interact with a specific drug. Pharmacokinetic evidence regarding this drug states that 'The increases in the AUC of ... | |
medium_convergence_03067 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this upregulation in one instance reports a log2 fold change of 1.166 and an adjusted p-value of 0.01918. Which protein is encoded by this gene? | G1/S-specific cyclin-D1 | Medium | convergence | {"qa_id":"medium_convergence_03067","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this upregulation in one instance reports a log2 fold change of 1.166... | |
medium_convergence_03068 | HOXB1 and KMT2C both interact with a shared transcription factor. Experimental evidence describes the formation of a ternary complex involving Prep1, this shared factor, and HOXB1 on a HOXB1-responsive target in vitro. Which protein is encoded by this shared transcription factor? | Pre-B-cell leukemia transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03068","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HOXB1 and KMT2C both interact with a shared transcription factor. Experimental evidence describes the formation of a ternary complex involving Prep1, this sh... | |
medium_convergence_03069 | BCAS2 and CSTF1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In [a cleavage stimulation factor subunit], a small region, highly conserved in metazoa, is responsible for interactions with two proteins, CstF-77 and symplekin, a nuclear protein of previously... | Cleavage stimulation factor subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_03069","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCAS2 and CSTF1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In [a cleavage stimulation fact... | |
medium_convergence_03070 | GH1 and JAK2 each interact with more than one shared gene. Evidence concerning one shared entity reports that a substrate-trapping mutant of a protein tyrosine phosphatase formed a stable interaction with this entity and TYK2 in response to interferon stimulation. Which disease is connected to that entity through genom... | childhood leukemia | Medium | convergence | {"qa_id":"medium_convergence_03070","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH1 and JAK2 each interact with more than one shared gene. Evidence concerning one shared entity reports that a substrate-trapping mutant of a protein tyrosi... | |
medium_convergence_03071 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.722 and an adjusted p-value of 0.001958. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM22 | Medium | convergence | {"qa_id":"medium_convergence_03071","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_03072 | FANCD2 and FANCB both interact with a shared protein partner. Evidence indicates that the direct interaction between this shared partner and FANCD2 was demonstrated in the yeast two-hybrid system. Which protein is encoded by this shared partner? | Fanconi anemia group E protein | Medium | convergence | {"qa_id":"medium_convergence_03072","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FANCB both interact with a shared protein partner. Evidence indicates that the direct interaction between this shared partner and FANCD2 was demon... | |
medium_convergence_03074 | EXOSC8 and DIS3 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which disease is connected to that entity through an association? | pontocerebellar hypoplasia, type 1D | Medium | convergence | {"qa_id":"medium_convergence_03074","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC8 and DIS3 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we demonstrate the association... | |
medium_convergence_03076 | ATXN7 and SUPT3H share common interacting partners. One such partner is a ubiquitin-specific protease that functions in the deubiquitination of histone H2B and interacts with Atx7. Which disease is associated with this specific protease as a biomarker? | non-small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03076","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATXN7 and SUPT3H share common interacting partners. One such partner is a ubiquitin-specific protease that functions in the deubiquitination of histone H2B a... | |
medium_convergence_03077 | FYN and HCK both interact with a specific shared protein. Evidence indicates that this shared protein is associated with the SH2 domain of Fyn, and is related to a protein alias and SKAP55, a protein with a molecular weight of 55 kDa. Which protein is encoded by this shared entity? | Src kinase-associated phosphoprotein 2 | Medium | convergence | {"qa_id":"medium_convergence_03077","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and HCK both interact with a specific shared protein. Evidence indicates that this shared protein is associated with the SH2 domain of Fyn, and is relate... | |
medium_convergence_03078 | DBF4 and CLSPN both interact with a specific shared protein. Evidence regarding this shared protein states: 'We also identified an interaction between MCM-BP and the Dbf4 regulatory component of the DDK kinase in both yeast 2-hybrid and insect cell co-expression assays, and this interaction was verified by co-immunopre... | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_03078","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and CLSPN both interact with a specific shared protein. Evidence regarding this shared protein states: 'We also identified an interaction between MCM-BP... | |
medium_convergence_03079 | DNAAF6 and CCDC39 are both associated with multiple shared biological processes. One shared process is linked to an entity for which functional analyses indicate localization to ciliary axonemes and an essential role in the assembly of inner dynein arms and the dynein regulatory complex. Which biological process is thi... | protein-containing complex assembly | Medium | convergence | {"qa_id":"medium_convergence_03079","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAAF6 and CCDC39 are both associated with multiple shared biological processes. One shared process is linked to an entity for which functional analyses indi... | |
medium_convergence_03081 | KIAA1549 and BRAP share multiple binding partners. One shared partner is known to interact with BRCA1-associated protein 2, thereby inhibiting the ERK signal transduction cascade. Which protein is encoded by this shared partner? | Kinase suppressor of Ras 1 | Medium | convergence | {"qa_id":"medium_convergence_03081","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KIAA1549 and BRAP share multiple binding partners. One shared partner is known to interact with BRCA1-associated protein 2, thereby inhibiting the ERK signal... | |
medium_convergence_03082 | FAF1 and EZH2 both interact with a specific shared protein. Evidence regarding this shared protein states: 'This study also found that FAF1 and IRF3 physically associate with this shared protein/importin-β3 and that overexpression of FAF1 reduces the interaction between IRF3 and this shared protein/importin-β3.' Which ... | Importin-5 | Medium | convergence | {"qa_id":"medium_convergence_03082","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF1 and EZH2 both interact with a specific shared protein. Evidence regarding this shared protein states: 'This study also found that FAF1 and IRF3 physical... | |
medium_convergence_03083 | Human polyomavirus 1 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) shows a log2 fold change of -1.348 and an adjusted p-value of 0.03637. Which protein is encoded by this gene? | Ly6/PLAUR domain-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_03083","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in renal epithelial cells (study G... |
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