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medium_convergence_03084 | SMURF1 and STK4 both interact with a specific shared protein. Evidence indicates that this shared protein is a core component of the U3 snoRNP complex, which is involved in pre-rRNA processing. Which protein is encoded by this shared entity? | U3 small nucleolar RNA-interacting protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03084","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMURF1 and STK4 both interact with a specific shared protein. Evidence indicates that this shared protein is a core component of the U3 snoRNP complex, which... | |
medium_convergence_03085 | PLK1 and SHC1 share multiple interacting partners. One such partner is described in evidence stating: 'The interaction of a MAPKAPK2 isoform with the 66 kDa isoform of ShcA, p66(ShcA), and HPH2 was confirmed using co-immunoprecipitation.' Which cell type is this specific shared partner enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03085","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and SHC1 share multiple interacting partners. One such partner is described in evidence stating: 'The interaction of a MAPKAPK2 isoform with the 66 kDa ... | |
medium_convergence_03086 | YAP1 and HDAC2 both interact with a specific shared protein. Experimental evidence indicates that YAP1 binds to the PY motif of this shared protein via its WW domains, thereby preventing the E3 ubiquitin ligase WWP1 from ubiquitinating it. Which protein is encoded by the gene corresponding to this shared entity? | Krueppel-like factor 5 | Medium | convergence | {"qa_id":"medium_convergence_03086","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and HDAC2 both interact with a specific shared protein. Experimental evidence indicates that YAP1 binds to the PY motif of this shared protein via its W... | |
medium_convergence_03087 | FOXM1 and LIN37 share multiple binding partners. One such shared partner has been shown to interact with FOXM1 to co-regulate the transcription of CDCA3. Which disease is associated with this specific shared partner through genomic alterations? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_03087","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXM1 and LIN37 share multiple binding partners. One such shared partner has been shown to interact with FOXM1 to co-regulate the transcription of CDCA3. Whi... | |
medium_convergence_03088 | Both Human gammaherpesvirus 4 and Measles morbillivirus are associated with the downregulation of a specific gene. Experimental data from gamma delta T-lymphocytes (study GSE13906) indicates that this gene exhibits a log2 fold change of -1.065 and an adjusted p-value of 0.04433. Which protein is encoded by this gene? | Kelch-like protein 4 | Medium | convergence | {"qa_id":"medium_convergence_03088","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Measles morbillivirus are associated with the downregulation of a specific gene. Experimental data from gamma delta T-lymph... | |
medium_convergence_03089 | SUMO2 and UBC each interact with more than one shared gene product. Evidence concerning one shared entity reports that GST pull-down and immunoprecipitation assays revealed that this entity bound directly and noncovalently to SUMO2/3, but not to SUMO1, and that the FHA domain of this entity was required for the binding... | E3 ubiquitin-protein ligase RNF8 | Medium | convergence | {"qa_id":"medium_convergence_03089","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SUMO2 and UBC each interact with more than one shared gene product. Evidence concerning one shared entity reports that GST pull-down and immunoprecipitation ... | |
medium_convergence_03090 | HDAC6 and HDAC5 both interact with a specific transcription factor. Evidence suggests that this factor, identified as a BCL6 relative, interacts with HDAC4, -5, and 7, implying that class II HDACs are largely involved in controlling the activity of POK transcription factors. Which protein is encoded by the gene corresp... | Zinc finger and BTB domain-containing protein 16 | Medium | convergence | {"qa_id":"medium_convergence_03090","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and HDAC5 both interact with a specific transcription factor. Evidence suggests that this factor, identified as a BCL6 relative, interacts with HDAC4, ... | |
medium_convergence_03091 | PTGES3 and CDC37 share multiple interacting partners. One such shared partner is implicated in a study where mutations (K97A and R101A) in its tetratricopeptide repeat (TPR) region, which are critical for Hsp90 binding, abolished its interactions with both CDC37 and stress-induced phosphoprotein 1. Which protein is enc... | Serine/threonine-protein phosphatase 5 | Medium | convergence | {"qa_id":"medium_convergence_03091","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PTGES3 and CDC37 share multiple interacting partners. One such shared partner is implicated in a study where mutations (K97A and R101A) in its tetratricopept... | |
medium_convergence_03092 | CEBPA and CSNK2A1 share a common interaction partner. Experimental evidence confirms the in vivo interaction of C/EBPalpha with this partner, specifically noting that the interaction involves the basic region of C/EBPalpha. Which disease is associated with this shared partner through genomic alterations? | pheochromocytoma | Medium | convergence | {"qa_id":"medium_convergence_03092","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and CSNK2A1 share a common interaction partner. Experimental evidence confirms the in vivo interaction of C/EBPalpha with this partner, specifically no... | |
medium_convergence_03093 | FANCD2 and VIRMA share common interaction partners. One such shared partner is reported to interact directly with minichromosome maintenance (MCM) proteins. Which disease is associated with this specific shared partner via a biomarker relationship? | microcephaly | Medium | convergence | {"qa_id":"medium_convergence_03093","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and VIRMA share common interaction partners. One such shared partner is reported to interact directly with minichromosome maintenance (MCM) proteins. ... | |
medium_convergence_03094 | ARCN1 and ARF4 both interact with a shared protein complex component. Experimental evidence for this specific shared entity includes immunoprecipitation and two-hybrid system analysis from a complete COP screen, which demonstrated physical interactions between alpha- and epsilon-COPs as well as between beta- and delta-... | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | Medium | convergence | {"qa_id":"medium_convergence_03094","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and ARF4 both interact with a shared protein complex component. Experimental evidence for this specific shared entity includes immunoprecipitation and ... | |
medium_convergence_03095 | CTBP1 and CTNNB1 share a common interaction partner. Evidence regarding one such partner states: 'Here we show that this protein forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression.' Which protein is encoded by this gene? | Zinc finger protein Gfi-1b | Medium | convergence | {"qa_id":"medium_convergence_03095","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTNNB1 share a common interaction partner. Evidence regarding one such partner states: 'Here we show that this protein forms complexes with β-caten... | |
medium_convergence_03096 | NELL1 and ATRAID are both involved in more than one shared biological process. Evidence indicates that NELL-1 significantly inhibits the proliferation of osteoblasts co-transfected with APR3 by further down-regulating Cyclin D1. Which biological process, connected to this evidence via a 'negatively regulates' relations... | osteoblast proliferation | Medium | convergence | {"qa_id":"medium_convergence_03096","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NELL1 and ATRAID are both involved in more than one shared biological process. Evidence indicates that NELL-1 significantly inhibits the proliferation of ost... | |
medium_convergence_03097 | CFTR and PTH1R share common interacting partners. One such partner is described in evidence stating: 'The specific and tight association suggests a potential regulatory role of this partner in cystic fibrosis transmembrane conductance regulator function.' Which protein is encoded by the gene corresponding to this inter... | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Medium | convergence | {"qa_id":"medium_convergence_03097","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and PTH1R share common interacting partners. One such partner is described in evidence stating: 'The specific and tight association suggests a potential... | |
medium_convergence_03098 | RACK1 and AHSA1 each interact with more than one shared protein. Evidence concerning one such shared protein reports that Hsp70 and Hsp90 associate equally with the wild-type and DeltaF508 forms of this protein, whereas nearly twice as much of the Hsp90 cochaperone Aha1 associates with the DeltaF508 form. Which protein... | Cystic fibrosis transmembrane conductance regulator | Medium | convergence | {"qa_id":"medium_convergence_03098","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and AHSA1 each interact with more than one shared protein. Evidence concerning one such shared protein reports that Hsp70 and Hsp90 associate equally w... | |
medium_convergence_03099 | ESR1 and PABPC1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation experiments showed that the extended eIF4GI binds PABP, while the N-terminally truncated original eIF4GI cannot.' Which protein is encoded by this specific interacting partner? | Eukaryotic translation initiation factor 4 gamma 3 | Medium | convergence | {"qa_id":"medium_convergence_03099","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and PABPC1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation experiments showed that the e... | |
medium_convergence_03100 | MYC and CUL3 share multiple interacting partners. One such partner is identified in a study stating: 'In this study, we found, by mass spectrometry, that Cullin-3 (CUL3)/KCTD10 ubiquitin (Ub) ligase forms a complex with [the shared partner].' Which protein is encoded by this shared partner? | Eukaryotic translation initiation factor 3 subunit D | Medium | convergence | {"qa_id":"medium_convergence_03100","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and CUL3 share multiple interacting partners. One such partner is identified in a study stating: 'In this study, we found, by mass spectrometry, that Cul... | |
medium_convergence_03101 | MYC and TRIM21 both interact with a shared protein. Evidence indicates that this shared protein binds c-Myc and recruits the E3 ubiquitin-protein ligase FBW7 to promote c-Myc degradation. Which disease is associated with this shared protein through genomic alterations? | asthma | Medium | convergence | {"qa_id":"medium_convergence_03101","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and TRIM21 both interact with a shared protein. Evidence indicates that this shared protein binds c-Myc and recruits the E3 ubiquitin-protein ligase FBW7... | |
medium_convergence_03102 | BRCC3 and RNF8 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Abraxas and this partner associate through coiled-coil domains on each protein. Which protein is encoded by that shared partner? | BRCA1-A complex subunit RAP80 | Medium | convergence | {"qa_id":"medium_convergence_03102","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCC3 and RNF8 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Abraxas and this part... | |
medium_convergence_03103 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.24 and an adjusted p-value of 0.0053. Which disease is associated with this gene through genomic alterations? | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03103","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_03104 | LAMTOR2 and ATP6V1E1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes, which we term Ragulator, interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation.' Which protein ... | Ras-related GTP-binding protein A | Medium | convergence | {"qa_id":"medium_convergence_03104","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and ATP6V1E1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A complex encoded by the MAPKSP1, ROBLD... | |
medium_convergence_03105 | AAK1 and AMPH both interact with a shared protein. Evidence regarding this shared protein states: 'Amphiphysin II truncation and deletion mutants identify two distinct clathrin-binding domains within this region: one with the sequence LLDLDFDP, the second with the sequence PWDLW.' Which disease is associated with this ... | intellectual disability, autosomal dominant 56 | Medium | convergence | {"qa_id":"medium_convergence_03105","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AAK1 and AMPH both interact with a shared protein. Evidence regarding this shared protein states: 'Amphiphysin II truncation and deletion mutants identify tw... | |
medium_convergence_03106 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of approximately -2.697 and an adjusted p-value of 0.01205. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_03106","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibite... | |
medium_convergence_03107 | DPYSL2 and EWSR1 both interact with a specific shared protein. Evidence indicates that the H2O2-dependent oxidation of this shared protein leads to the formation of a mixed disulfide with CRMP2, a reaction reversed by thioredoxin. Which protein is encoded by the gene corresponding to this shared entity? | Peroxiredoxin-2 | Medium | convergence | {"qa_id":"medium_convergence_03107","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DPYSL2 and EWSR1 both interact with a specific shared protein. Evidence indicates that the H2O2-dependent oxidation of this shared protein leads to the forma... | |
medium_convergence_03108 | HSP90AA1 and MAVS share common interacting partners. One such shared partner is reported to be ubiquitinated by CHIP when CHIP is bound to HSP90. Which protein encodes this specific shared partner? | Ubiquitin carboxyl-terminal hydrolase 35 | Medium | convergence | {"qa_id":"medium_convergence_03108","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and MAVS share common interacting partners. One such shared partner is reported to be ubiquitinated by CHIP when CHIP is bound to HSP90. Which prote... | |
medium_convergence_03110 | Both Human mastadenovirus C and Zika virus have been shown to downregulate a specific host gene. In a study of lung fibroblast cell lines (GSE120891), evidence for this shared target reports a log2 fold change of approximately -1.16 and an adjusted p-value of 0.03813. Which cellular component is this gene located in? | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_03110","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Zika virus have been shown to downregulate a specific host gene. In a study of lung fibroblast cell lines (GSE120891), eviden... | |
medium_convergence_03111 | ESR1 and HDAC1 share multiple interacting partners. One such shared partner forms complexes with Sp1 that associate with histone deacetylases (HDACs) 1 and 2. Which protein is encoded by this shared partner? | Transcription factor Sp3 | Medium | convergence | {"qa_id":"medium_convergence_03111","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC1 share multiple interacting partners. One such shared partner forms complexes with Sp1 that associate with histone deacetylases (HDACs) 1 and 2... | |
medium_convergence_03112 | Both Human betaherpesvirus 5 and Human orthopneumovirus are known to upregulate a specific shared gene. Experimental evidence for this gene reports a log2 fold change of approximately 1.148 and an adjusted p-value of 0.03003. Which cellular component is this gene located in? | cytoplasmic side of plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_03112","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Human orthopneumovirus are known to upregulate a specific shared gene. Experimental evidence for this gene reports a log2 fo... | |
medium_convergence_03113 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.669 and an adjusted p-value of 0.003917. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_03113","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_03114 | KAT5 and UHRF2 both interact with a specific shared protein. Experimental evidence indicates that the chromatin remodeling protein Tip60 interacts directly with this shared entity in a yeast two-hybrid system. Which disease is associated with this entity through genomic alterations? | childhood leukemia | Medium | convergence | {"qa_id":"medium_convergence_03114","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and UHRF2 both interact with a specific shared protein. Experimental evidence indicates that the chromatin remodeling protein Tip60 interacts directly w... | |
medium_convergence_03115 | ESR1 and NFIX share a common interaction partner. Evidence regarding this shared partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), responsible for the interaction with this partner, the suppression of ER by this partner could be reversed, suggesting that this suppression is conferred by the... | Nuclear receptor subfamily 2 group C member 1 | Medium | convergence | {"qa_id":"medium_convergence_03115","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and NFIX share a common interaction partner. Evidence regarding this shared partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340... | |
medium_convergence_03116 | IKBKB and CARD11 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We show that a MAP3K7 family member physically interacts with NIK and with IKK2, and both XIAP or active MAP3K7 family member can stimulate IKK2 kinase activity.' Which disease is connected to that entity t... | cardiospondylocarpofacial syndrome | Medium | convergence | {"qa_id":"medium_convergence_03116","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKBKB and CARD11 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We show that a MAP3K7 family member physica... | |
medium_convergence_03118 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately 1.643 and an adjusted p-value of approximately 0.011. Which biological process is this gene involved in? | positive regulation of inflammatory response | Medium | convergence | {"qa_id":"medium_convergence_03118","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_03119 | FBXW11 and GSK3B share multiple interacting partners. One such partner is identified in a study where two-dimensional gel electrophoresis and site-directed mutagenesis revealed that glycogen synthase kinase 3β (GSK-3β) phosphorylates two serine residues within the DSGISL sequence of this transcription factor. Which dis... | immunodeficiency, developmental delay, and hypohomocysteinemia | Medium | convergence | {"qa_id":"medium_convergence_03119","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and GSK3B share multiple interacting partners. One such partner is identified in a study where two-dimensional gel electrophoresis and site-directed m... | |
medium_convergence_03120 | AKAP9 and CDK5RAP2 share multiple binding partners. One shared partner is implicated in a study where BioID identified known physically interacting proteins and a new interaction between this partner and CDK5RAP2, consistent with the partner's function in pericentriolar material (PCM) recruitment. Which protein is enco... | Centrosomal protein of 152 kDa | Medium | convergence | {"qa_id":"medium_convergence_03120","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and CDK5RAP2 share multiple binding partners. One shared partner is implicated in a study where BioID identified known physically interacting proteins ... | |
medium_convergence_03121 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) shows a log2 fold change of approximately 3.117 and an adjusted p-value of 0.04592. Which protein is encoded by t... | Histone H2A type 1-B/E | Medium | convergence | {"qa_id":"medium_convergence_03121","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data for this gene in a non-small cel... | |
medium_convergence_03122 | ING1 and BAHCC1 both interact with a shared protein. Evidence indicates that the N-terminus of p33ING1b, which is divergent among a family of ING1 polypeptides, associates with the Sin3 complex through direct interaction with this shared protein. Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03122","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ING1 and BAHCC1 both interact with a shared protein. Evidence indicates that the N-terminus of p33ING1b, which is divergent among a family of ING1 polypeptid... | |
medium_convergence_03123 | COPS6 and COPS4 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The immunoprecipitation assay verified that COP9 signalosome subunit 6 (CSN6) interacted with CULA4.' Which protein is encoded by the gene corresponding to that shared partner? | Cullin-4A | Medium | convergence | {"qa_id":"medium_convergence_03123","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and COPS4 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The immunoprecipitation assay v... | |
medium_convergence_03124 | PLK1 and BRCA1 share multiple interacting partners. One such shared partner is a unique component of the mTORC2 complex, and evidence indicates that its direct interaction with BRCA1 is required for mTORC2 activation. Which protein is encoded by this shared partner? | Target of rapamycin complex 2 subunit MAPKAP1 | Medium | convergence | {"qa_id":"medium_convergence_03124","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and BRCA1 share multiple interacting partners. One such shared partner is a unique component of the mTORC2 complex, and evidence indicates that its dire... | |
medium_convergence_03125 | CPLX1 and SLC17A7 each interact with more than one shared protein partner. Evidence concerning one such shared partner states that Complexin binds in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. Which protein is encoded by the gene corresponding to that shared... | Synaptosomal-associated protein 25 | Medium | convergence | {"qa_id":"medium_convergence_03125","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CPLX1 and SLC17A7 each interact with more than one shared protein partner. Evidence concerning one such shared partner states that Complexin binds in an anti... | |
medium_convergence_03126 | HRAS and NTRK1 share common interacting partners. One such partner is implicated in a mechanism where its phosphorylation enhances its interaction with Ras, thereby reducing the binding of p120-RasGAP to Ras. Which protein is encoded by the gene corresponding to this specific interacting partner? | Protein Niban 2 | Medium | convergence | {"qa_id":"medium_convergence_03126","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and NTRK1 share common interacting partners. One such partner is implicated in a mechanism where its phosphorylation enhances its interaction with Ras, ... | |
medium_convergence_03127 | CSNK2B and FEN1 both interact with a common protein partner. Evidence regarding one such partner indicates that a PCNA-interacting box (PIP box)-containing peptide derived from hFEN1 binds tightly to the interdomain connecting loop of this partner. Which protein is encoded by the gene corresponding to this partner? | Cell cycle checkpoint protein RAD1 | Medium | convergence | {"qa_id":"medium_convergence_03127","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and FEN1 both interact with a common protein partner. Evidence regarding one such partner indicates that a PCNA-interacting box (PIP box)-containing p... | |
medium_convergence_03128 | BRD7 and PBRM1 share common interaction partners. One such partner is characterized by experimental evidence stating: 'The results showed that BRD7 could interact with this protein and the region from amino acid 430 to 798 of this protein was critical for the interaction of this protein with BRD7.' Which protein is enc... | Bromodomain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03128","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD7 and PBRM1 share common interaction partners. One such partner is characterized by experimental evidence stating: 'The results showed that BRD7 could int... | |
medium_convergence_03129 | ESR1 and NFIB share a common interaction partner. Evidence regarding this partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), responsible for the interaction with this partner, the suppression of ER by this partner could be reversed, suggesting that this suppression is conferred by the direct... | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_03129","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and NFIB share a common interaction partner. Evidence regarding this partner states: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), resp... | |
medium_convergence_03131 | Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately 2.56 and an adjusted p-value of 0.0245. Which protein is encoded by this gene? | XIAP-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03131","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (f... | |
medium_convergence_03132 | KCNE5 and ANK2 are both associated with multiple shared biological processes. One of these shared processes involves an entity that has been shown to modify the transient outward current (I(to)), a current that plays a key role in determining the repolarization process in the myocardium. Which biological process is thi... | regulation of cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_03132","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNE5 and ANK2 are both associated with multiple shared biological processes. One of these shared processes involves an entity that has been shown to modify ... | |
medium_convergence_03134 | EGFR and TRAF6 share a common interacting partner. Evidence for one such partner states: 'Here, we report that the protein directly binds to TRAF6 in vivo and in vitro.' Which protein is encoded by this specific interacting partner? | Numb-like protein | Medium | convergence | {"qa_id":"medium_convergence_03134","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and TRAF6 share a common interacting partner. Evidence for one such partner states: 'Here, we report that the protein directly binds to TRAF6 in vivo an... | |
medium_convergence_03135 | ERC1 and CARD11 both interact with a shared protein. Evidence regarding this shared protein states: 'Although mutants defective in ubiquitin binding permit ATM-dependent TAK1 activation, they block association with ELKS and IKK activation.' Which protein is encoded by the gene corresponding to this shared entity? | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_03135","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERC1 and CARD11 both interact with a shared protein. Evidence regarding this shared protein states: 'Although mutants defective in ubiquitin binding permit A... | |
medium_convergence_03136 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.58 and an adjusted p-value of approximately 0.046. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03136","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_03137 | SCAP and INSIG1 both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor forms a complex with SCAP, which can be co-immunoprecipitated using antibodies against either protein. Which protein is encoded by the gene corresponding to this transcription factor? | Sterol regulatory element-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03137","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SCAP and INSIG1 both interact with a specific transcription factor. Experimental evidence indicates that this transcription factor forms a complex with SCAP,... | |
medium_convergence_03138 | DAXX and RCHY1 share common interaction partners. One such shared partner is described in the following context: 'Here, we show that Axin, originally identified for its scaffolding role to control beta-catenin levels in Wnt signaling, strongly associates with DAXX at endogenous levels.' Which protein is encoded by this... | Axin-1 | Medium | convergence | {"qa_id":"medium_convergence_03138","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and RCHY1 share common interaction partners. One such shared partner is described in the following context: 'Here, we show that Axin, originally identif... | |
medium_convergence_03139 | EP300 and IRF8 share a common interaction partner. Evidence regarding this shared partner states: 'Surface-enhanced laser desorption ionization MS proteomic analysis and a yeast two-hybrid screen showed independently that the corepressor [Gene: COPS2] interacts with the CREB-binding protein (CBP) coactivator.' Which pr... | COP9 signalosome complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_03139","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and IRF8 share a common interaction partner. Evidence regarding this shared partner states: 'Surface-enhanced laser desorption ionization MS proteomic ... | |
medium_convergence_03140 | SMAD7 and UBB each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it binds to the SMAD7-SMURF2 complex, deubiquitinates and stabilizes the type I TGF-β receptor (TβR-I), and thereby enhances TGF-β signaling. Which protein is encoded by the gene corresponding ... | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | convergence | {"qa_id":"medium_convergence_03140","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and UBB each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it binds to the SMAD7-SMURF2 c... | |
medium_convergence_03141 | Both Measles morbillivirus and Influenza A virus are reported to downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) shows a log2 fold change of approximately -2.08 and an adjusted p-value of 0.03875. Which protein is encoded by this gene? | Palmdelphin | Medium | convergence | {"qa_id":"medium_convergence_03141","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are reported to downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells ... | |
medium_convergence_03143 | EP300 and PYGO2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A monoclonal antibody raised against the carboxyl terminus of this protein coimmunoprecipitates CBP/p300, supporting the model that this protein is a CBP binding protein and that these proteins can be found ... | Floating-Harbor syndrome | Medium | convergence | {"qa_id":"medium_convergence_03143","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and PYGO2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A monoclonal antibody raised against the car... | |
medium_convergence_03144 | AGK and KSR1 share common binding partners. One such partner is constitutively associated with C-TAK1, which phosphorylates serine 392 of this partner to promote 14-3-3 binding and cytoplasmic sequestration in unstimulated cells. Which cell type is enriched for this specific shared partner? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03144","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGK and KSR1 share common binding partners. One such partner is constitutively associated with C-TAK1, which phosphorylates serine 392 of this partner to pro... | |
medium_convergence_03145 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of approximately 2.562 and an adjusted p-value of 0.02074. Which protein is encoded by this gene? | C-C motif chemokine 20 | Medium | convergence | {"qa_id":"medium_convergence_03145","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a ... | |
medium_convergence_03146 | RAD51 and EXO1 both interact with a specific shared protein partner. Evidence regarding this partner states: 'Using the yeast two-hybrid system, we isolated a cDNA encoding a novel human protein, named [REDACTED], that strongly interacts with human Rad51 recombinase.' Which protein is encoded by this shared partner? | RAD51-associated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03146","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and EXO1 both interact with a specific shared protein partner. Evidence regarding this partner states: 'Using the yeast two-hybrid system, we isolated ... | |
medium_convergence_03147 | Vaccinia virus and Dengue virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -3.45 and an adjusted p-value of 0.021. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03147","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_03148 | Interleukin-2 (IL-2) and Interleukin-21 (IL-21) are both involved in a shared biological process. Evidence indicates that IL-23, IL-2, IL-15, IL-18, and IL-21 all enhance the secretion of Interleukin-17 (IL-17). Which biological process, connected to IL-17 production via a 'positively regulates' relationship, is shared... | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_03148","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interleukin-2 (IL-2) and Interleukin-21 (IL-21) are both involved in a shared biological process. Evidence indicates that IL-23, IL-2, IL-15, IL-18, and IL-2... | |
medium_convergence_03149 | Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) reports a log2 fold change of approximately 1.404 and an adjusted p-value of 0.005249. Which pr... | B-cell lymphoma 3 protein | Medium | convergence | {"qa_id":"medium_convergence_03149","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for thi... | |
medium_convergence_03150 | MEIS1 and KMT2C share multiple binding partners. One such shared partner is Activating signal cointegrator-2 (ASC-2), which functions as a coactivator for transcription factors including the retinoic acid receptor (RAR) and associates with histone H3-K4 methyltransferases MLL3 and MLL4 in the context of mixed-lineage l... | small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03150","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MEIS1 and KMT2C share multiple binding partners. One such shared partner is Activating signal cointegrator-2 (ASC-2), which functions as a coactivator for tr... | |
medium_convergence_03151 | BRD8 and EPC1 share multiple protein interaction partners. One such partner was identified as interacting with BRD8 through yeast two-hybrid screening and subsequent immunoprecipitation analysis. Which disease is associated with this specific shared partner? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03151","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and EPC1 share multiple protein interaction partners. One such partner was identified as interacting with BRD8 through yeast two-hybrid screening and su... | |
medium_convergence_03152 | PFDN6 and RUVBL2 both interact with a shared protein. Evidence indicates that Reptin, a highly conserved AAA+ ATPase involved in chromatin-remodeling complexes, associates with this shared protein, as demonstrated by immunoprecipitation and confocal microscopic analysis. Which cell type is this shared protein enriched ... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03152","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PFDN6 and RUVBL2 both interact with a shared protein. Evidence indicates that Reptin, a highly conserved AAA+ ATPase involved in chromatin-remodeling complex... | |
medium_convergence_03155 | ACTR2 and AVPR2 both interact with a common protein partner. Evidence regarding this shared partner indicates that its NTA region interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which protein is encoded by ... | Src substrate cortactin | Medium | convergence | {"qa_id":"medium_convergence_03155","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR2 and AVPR2 both interact with a common protein partner. Evidence regarding this shared partner indicates that its NTA region interacts directly with the... | |
medium_convergence_03156 | CENPU and HIST1H4A share multiple binding partners. One shared partner is described by evidence stating: 'Bacterially expressed this protein binds at a stoichiometric ratio to the CENP-A/H4 tetramer but not to the H3/H4 tetramer.' Which protein is encoded by the gene corresponding to this shared partner? | Holliday junction recognition protein | Medium | convergence | {"qa_id":"medium_convergence_03156","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPU and HIST1H4A share multiple binding partners. One shared partner is described by evidence stating: 'Bacterially expressed this protein binds at a stoic... | |
medium_convergence_03157 | NES and RCHY1 both interact with multiple shared gene products. One such shared entity is implicated in a study reporting the identification of Pirh2, a RING-H2-type ubiquitin E3 ligase, as a novel binding partner of the cytoplasmic intermediate filament proteins keratin 8/18 (K8/18). Which protein is encoded by that s... | Keratin, type I cytoskeletal 18 | Medium | convergence | {"qa_id":"medium_convergence_03157","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NES and RCHY1 both interact with multiple shared gene products. One such shared entity is implicated in a study reporting the identification of Pirh2, a RING... | |
medium_convergence_03159 | Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. In a study of macrophages (GSE108897), the upregulation of this gene by these viruses was associated with a log2 fold change of approximately 1.49 and an adjusted p-value of 0.0015. Which protein is encoded by this gene? | Zinc finger protein 367 | Medium | convergence | {"qa_id":"medium_convergence_03159","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. In a study of macrophages (GSE108897), the upregulation of t... | |
medium_convergence_03161 | ATR and BRIP1 share common binding partners. One such shared partner is phosphorylated by ATR (the ATM- and Rad3-related protein kinase) at specific sites in vitro. Which disease is associated with this shared partner through genomic alterations? | candidiasis | Medium | convergence | {"qa_id":"medium_convergence_03161","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and BRIP1 share common binding partners. One such shared partner is phosphorylated by ATR (the ATM- and Rad3-related protein kinase) at specific sites in... | |
medium_convergence_03162 | Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of 1.291 and an adjusted p-value of 0.002292. In which cell type is this gene enriched? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_03162","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of 1.291 ... | |
medium_convergence_03163 | CTNND1 and CDH1 both interact with a shared transcription factor. Evidence regarding this entity states: 'Using p120 as bait, we conducted a yeast two-hybrid screen and identified a novel transcription factor which we named [REDACTED].' Which cell type is this entity enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03163","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNND1 and CDH1 both interact with a shared transcription factor. Evidence regarding this entity states: 'Using p120 as bait, we conducted a yeast two-hybrid... | |
medium_convergence_03164 | COPA and ARFGAP1 both interact with a shared protein partner. Evidence regarding this partner states: 'Here we report the ubiquitous expression of two novel isotypes of coatomer subunits gamma- and zeta-COP that are incorporated into coatomer, and show that three isotypes exist of the complex defined by the subunit com... | Coatomer subunit gamma-2 | Medium | convergence | {"qa_id":"medium_convergence_03164","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPA and ARFGAP1 both interact with a shared protein partner. Evidence regarding this partner states: 'Here we report the ubiquitous expression of two novel ... | |
medium_convergence_03165 | Both TG and NCOR2 share a binding partner. Evidence regarding one such shared entity states: 'In electrophoretic mobility shift assays, wild-type [Thyroid hormone receptor beta isoform 1] interacted with N-CoR in the absence of ligand, whereas T3 caused dissociation of the [Thyroid hormone receptor beta isoform 1]/N-Co... | Thyroid hormone receptor beta | Medium | convergence | {"qa_id":"medium_convergence_03165","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both TG and NCOR2 share a binding partner. Evidence regarding one such shared entity states: 'In electrophoretic mobility shift assays, wild-type [Thyroid ho... | |
medium_convergence_03166 | Both Cardiovirus A and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122967) indicates that this gene exhibits a log2 fold change of approximately 1.754 and an adjusted p-value of 0.01032. Which cellular component is this gene l... | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_03166","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Cardiovirus A and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental data from a study on cervical adenocarcinoma cell lines ... | |
medium_convergence_03167 | ABI2 and ABL1 each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Here we show that Bcr/Abl tyrosine kinase, and three tyrosine phosphorylated proteins (115, 120 and 155 kDa) are co-immunoprecipitated with antibody against the shared entity from lysates of the human... | SH2/SH3 adapter protein NCK1 | Medium | convergence | {"qa_id":"medium_convergence_03167","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABI2 and ABL1 each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Here we show that Bcr/Abl tyrosine ki... | |
medium_convergence_03168 | DBF4 and ORC1 both physically interact with a common protein partner. Evidence regarding one such partner states: 'Further analyses indicate that this protein physically interacts with ORC1 on non-chromatin nuclear structures.' Which disease is associated with this specific protein partner? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | convergence | {"qa_id":"medium_convergence_03168","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and ORC1 both physically interact with a common protein partner. Evidence regarding one such partner states: 'Further analyses indicate that this protei... | |
medium_convergence_03170 | EFNB1 and ARHGEF7 both interact with a specific shared protein. Evidence indicates that in the brain, Piccolo forms a complex with this shared protein along with various GIT-associated proteins, including betaPIX, focal adhesion kinase, liprin-alpha, and paxillin. Which protein is encoded by the gene corresponding to t... | ARF GTPase-activating protein GIT1 | Medium | convergence | {"qa_id":"medium_convergence_03170","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EFNB1 and ARHGEF7 both interact with a specific shared protein. Evidence indicates that in the brain, Piccolo forms a complex with this shared protein along ... | |
medium_convergence_03172 | MYC and SAP130 both interact with a shared protein partner. Evidence regarding this partner states: 'Here we show that Myc co-recruits this partner and GCN5 via direct physical interactions of its N-terminal activation/transformation domain with the human STAGA (SPT3-TAF-GCN5 acetylase) coactivator complex.' Which prot... | Transformation/transcription domain-associated protein | Medium | convergence | {"qa_id":"medium_convergence_03172","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and SAP130 both interact with a shared protein partner. Evidence regarding this partner states: 'Here we show that Myc co-recruits this partner and GCN5 ... | |
medium_convergence_03174 | CBX8 and CBX2 both interact with a shared protein partner. Evidence regarding one such partner states: 'By crosslinking mass spectrometry, we identified novel interactions between this partner and the three non-catalytic subunits.' Which disease is associated with that specific protein partner? | Luo-Schoch-Yamamoto syndrome | Medium | convergence | {"qa_id":"medium_convergence_03174","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX8 and CBX2 both interact with a shared protein partner. Evidence regarding one such partner states: 'By crosslinking mass spectrometry, we identified nove... | |
medium_convergence_03175 | CBX5 and HIST1H4A share a common interaction partner. Evidence regarding this shared partner indicates that amino-acid substitutions in its PxVxL motif abolish interaction with members of the heterochromatin protein 1 (HP1) family and prevent its centromeric localization in differentiated cells. Which protein is encode... | Transcription intermediary factor 1-beta | Medium | convergence | {"qa_id":"medium_convergence_03175","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX5 and HIST1H4A share a common interaction partner. Evidence regarding this shared partner indicates that amino-acid substitutions in its PxVxL motif aboli... | |
medium_convergence_03176 | COPB1 and ARCN1 share a common interacting partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which disease is associated with this shared partner as ... | scleroderma | Medium | convergence | {"qa_id":"medium_convergence_03176","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and ARCN1 share a common interacting partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consist... | |
medium_convergence_03177 | CHD4 and CHEK2 both interact with a shared protein partner. Experimental evidence indicates that the purification of a complex involving this shared partner allowed for the identification of CHD4 as an associated protein via tandem mass spectrometric sequencing. Which protein is encoded by this shared partner? | Serine/threonine-protein kinase ATR | Medium | convergence | {"qa_id":"medium_convergence_03177","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and CHEK2 both interact with a shared protein partner. Experimental evidence indicates that the purification of a complex involving this shared partner ... | |
medium_convergence_03178 | CSNK1D and KMT2A both interact with a specific shared protein. Evidence indicates that human casein kinase I delta (hCKIdelta), the closest homologue to hCKIepsilon, associates with and phosphorylates this shared protein, leading to its instability. In which cellular component is this shared protein located? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_03178","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1D and KMT2A both interact with a specific shared protein. Evidence indicates that human casein kinase I delta (hCKIdelta), the closest homologue to hCKI... | |
medium_convergence_03179 | Dengue virus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of -2.975 and an adjusted p-value of 0.01757. Which disease is associated with this gene through genomic alterations? | atherosclerosis | Medium | convergence | {"qa_id":"medium_convergence_03179","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change... | |
medium_convergence_03180 | Primate erythroparvovirus 1 and Cardiovirus A both upregulate a specific gene in erythroid progenitor cells. Experimental data for this gene shows a log2 fold change of 1.023 and an adjusted p-value of 0.04293. Which protein is encoded by this gene? | Interferon-stimulated gene 20 kDa protein | Medium | convergence | {"qa_id":"medium_convergence_03180","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Cardiovirus A both upregulate a specific gene in erythroid progenitor cells. Experimental data for this gene shows a log2 fol... | |
medium_convergence_03181 | CDK2 and PIN1 both interact with a shared protein. Evidence indicates that this shared protein interacts with a nuclear receptor corepressor both in vitro and in mammalian cells. Which protein is encoded by this shared entity? | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_03181","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and PIN1 both interact with a shared protein. Evidence indicates that this shared protein interacts with a nuclear receptor corepressor both in vitro an... | |
medium_convergence_03182 | CHMP4B and CHMP4C both interact with a specific protein. Evidence regarding this protein describes its interactions with another ESCRT-III component, CHMP4b/Shax (Snf7 homologue associated with Alix), and with EAP20 (ELL-associated protein 20), a human counterpart of yeast Vps25 and a component of ESCRT-II. These inter... | Charged multivesicular body protein 6 | Medium | convergence | {"qa_id":"medium_convergence_03182","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP4C both interact with a specific protein. Evidence regarding this protein describes its interactions with another ESCRT-III component, CHMP4b/... | |
medium_convergence_03183 | Both Hepacivirus C and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.048 and an adjusted p-value of 0.005204 in peripheral blood mononuclear cells. Which disease is causally linked to this gene? | pulmonary edema | Medium | convergence | {"qa_id":"medium_convergence_03183","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data for this gene shows a log2 fold change o... | |
medium_convergence_03184 | WNT2 and WNT3 are both involved in more than one shared biological process. One of these shared processes is described in the literature as a novel regulator of dopaminergic progenitors and dopaminergic neuron development. Which biological process is this shared entity a part of? | midbrain development | Medium | convergence | {"qa_id":"medium_convergence_03184","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT2 and WNT3 are both involved in more than one shared biological process. One of these shared processes is described in the literature as a novel regulator... | |
medium_convergence_03185 | PSMA1 and PSMB2 both interact with a shared protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subunit beta2 is required for beta2's interaction with adjacent beta3, whereas the C-terminal extension of immunosubunit beta2i is dispensable for beta2i's interaction ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_03185","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA1 and PSMB2 both interact with a shared protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subun... | |
medium_convergence_03186 | Asparaginase (Escherichia coli) and Anakinra both interact with a specific drug. Evidence indicates that this drug, when used in combination with Anakinra and corticosteroids, may obviate the need for cytotoxic approaches. Which disease is this drug indicated for? | graft versus host disease | Medium | convergence | {"qa_id":"medium_convergence_03186","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Asparaginase (Escherichia coli) and Anakinra both interact with a specific drug. Evidence indicates that this drug, when used in combination with Anakinra an... | |
medium_convergence_03187 | DDX3X and PPARG both interact with a specific shared protein. Evidence indicates that DDX3 interacts with hepatocyte nuclear factor 4 (HNF4) and a small heterodimer partner, and synergistically up-regulates HNF4-mediated transactivation of the MTP promoter via its ATPase activity. Which protein is encoded by the gene c... | Nuclear receptor subfamily 0 group B member 2 | Medium | convergence | {"qa_id":"medium_convergence_03187","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX3X and PPARG both interact with a specific shared protein. Evidence indicates that DDX3 interacts with hepatocyte nuclear factor 4 (HNF4) and a small hete... | |
medium_convergence_03188 | Influenza A virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study GSE106279) shows a log2 fold change of approximately -1.43 and an adjusted p-value of 0.0178. Which cellular component is this gene located in? | Golgi apparatus | Medium | convergence | {"qa_id":"medium_convergence_03188","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Influenza A virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study GSE1... | |
medium_convergence_03189 | GRB2 and JUN share multiple interacting partners. One such partner is described in a study reporting a specific interaction between its COOH-terminal SH3 domain and the NH2-terminal regulatory domain of a mitogen-activated protein kinase kinase kinase in ER22 cells overexpressing the EGF receptor. Which cellular compon... | tight junction | Medium | convergence | {"qa_id":"medium_convergence_03189","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and JUN share multiple interacting partners. One such partner is described in a study reporting a specific interaction between its COOH-terminal SH3 dom... | |
medium_convergence_03191 | Human immunodeficiency virus 1 and Orthohepevirus A both downregulate a specific gene. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -1.077 and an adjusted p-value of 0.005077. Which protein is encoded by this gene? | ATPase inhibitor, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_03191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human immunodeficiency virus 1 and Orthohepevirus A both downregulate a specific gene. Evidence for this gene in macrophages (from study GSE108897) reports a... | |
medium_convergence_03192 | MAPK1 and RPS6KA1 share multiple interacting partners. One such partner is distinguished by experimental evidence showing that ERK1 and ERK2 were detected in its immunoprecipitates (along with those of a related kinase), but were absent from RSK1 immunoprecipitates. Which protein is encoded by this specific shared part... | Ribosomal protein S6 kinase alpha-3 | Medium | convergence | {"qa_id":"medium_convergence_03192","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and RPS6KA1 share multiple interacting partners. One such partner is distinguished by experimental evidence showing that ERK1 and ERK2 were detected in... | |
medium_convergence_03194 | ASXL1 and MDM2 both interact with a shared protein. Evidence regarding this shared entity states: 'We determined that p48 binds to the p53 E3 ligase HDM2, enhancing HDM2-p53 association and thereby promoting p53 polyubiquitination and degradation to reduce steady-state p53 levels and activity.' Which protein is encoded... | Proliferation-associated protein 2G4 | Medium | convergence | {"qa_id":"medium_convergence_03194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASXL1 and MDM2 both interact with a shared protein. Evidence regarding this shared entity states: 'We determined that p48 binds to the p53 E3 ligase HDM2, en... | |
medium_convergence_03195 | STAM2 and EPS15 each interact with more than one shared protein. Evidence concerning one such shared entity indicates that it and SARA interact with the ESCRT-0 subunits STAM2 and Eps15b, but only this entity associates with the core subunit Hrs. Which protein is encoded by the gene corresponding to that entity? | RING finger protein 11 | Medium | convergence | {"qa_id":"medium_convergence_03195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STAM2 and EPS15 each interact with more than one shared protein. Evidence concerning one such shared entity indicates that it and SARA interact with the ESCR... | |
medium_convergence_03196 | PRKN and PPP2CA both interact with a shared protein. Evidence indicates that Parkin directly binds to this protein via its C terminus and mediates its mono-ubiquitination, thereby increasing its steady-state levels. Which gene encodes this protein? | Apoptosis regulator Bcl-2 | Medium | convergence | {"qa_id":"medium_convergence_03196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and PPP2CA both interact with a shared protein. Evidence indicates that Parkin directly binds to this protein via its C terminus and mediates its mono-u... | |
medium_convergence_03197 | CDK1 and CDC6 both interact with a specific protein. Evidence indicates that this protein binds strongly to ORC1 and MCM7. Which protein is encoded by the gene corresponding to this interacting partner? | Origin recognition complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_03197","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK1 and CDC6 both interact with a specific protein. Evidence indicates that this protein binds strongly to ORC1 and MCM7. Which protein is encoded by the ge... |
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