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2,100
The use of implantable cardioverter-defibrillators in pediatric patients awaiting heart transplantation.
This multicenter study evaluated experience with implantable cardioverter defibrillators (ICD) as a bridge to orthotopic heart transplantation (OHT) in children.</AbstractText>The application of ICD therapy continues to expand in pediatric populations, due in part to improved technology and new indications, including t...
2,101
[Cardiac insufficiency in the African cardiology milieu].
The aim of this study is to determine the frequency, the aetiologies and the hospital mortality of heart failure in African developing countries.</AbstractText>A prospective study rolled over six months in African urban hospital including 170 patients, middle age 50 years old suffering from heart failure. They underwen...
2,102
Cardiac arrest and resuscitation epidemiology in Singapore (CARE I study).
To describe the epidemiology of out-of-hospital cardiac arrest (OHCA) in Singapore, the emergency medical services (EMS) response, and to identify possible areas for improvement.</AbstractText>This prospective observational study constitutes phase I of the Cardiac Arrest and Resuscitation Epidemiology (CARE) project. I...
2,103
Adverse prognosis of patients with hypertrophic cardiomyopathy who have epicardial coronary artery disease.
Adult patients with hypertrophic cardiomyopathy (HCM) may develop concomitant atherosclerotic coronary artery disease (CAD). There is a paucity of data on the clinical outcomes of HCM patients who have CAD.</AbstractText>We examined the outcome of 433 adult patients with HCM according to the presence and severity of CA...
2,104
Calcitonin gene-related peptide protects against whole body ischemia in a porcine model of cardiopulmonary resuscitation.
The present study was designed to investigate the protective effects of calcitonin gene-related peptide (CGRP) in a porcine model of cardiopulmonary resuscitation (CPR). Twelve pigs were anesthetized, paralyzed, mechanically ventilated with oxygen, and were monitored for electrocardiograph (ECG), arterial pressure, rig...
2,105
Management of ventricular fibrillation or unstable ventricular tachycardia in patients with congenital long-QT syndrome: a suggested modification to ACLS guidelines.
Prolongation of the QT interval is a known risk factor for syncope, seizures and sudden cardiac death. Most patients with QT prolongation have an acquired cause, but congenital forms of QT prolongation are being increasingly recognized. However, existing advanced cardiac life support (ACLS) treatment algorithms for pro...
2,106
Cardiac arrest survival as a function of ambulance deployment strategy in a large urban emergency medical services system.
This study examines the effect of paramedic deployment strategy on witnessed ventricular fibrillation (VF) cardiac arrest outcomes. Our null hypothesis was that there is no difference in survival between an EMS system using targeted response (TR) and one using a uniform or all advanced life support (ALS) response (UR) ...
2,107
Fatal cardiac arrest following blunt chest trauma 17 years after a Senning operation.
Although frequent in patients who have undergone Senning or Mustard operations, cardiac arrhythmias after blunt chest trauma have not been reported. We report the case of a 17-year-old boy with ventricular fibrillation after a minor blow to the chest.
2,108
[Clinical case of the month. Rapid atrial fibrillation causing ventricular tachycardia and syncope].
We report a rare case of rapid atrial fibrillation triggering an episode of ventricular tachycardia. We review the literature and discuss the potential mechanisms of the ventricular arrhythmia.
2,109
Implantable cardioverter-defibrillator placement in patients with mild-to- moderate left ventricular dysfunction: hemodynamics and recovery profile with two different anesthetics used during deep sedation.
To compare the effects of thiopental and propofol during defibrillation threshold testing (DFT) on hemodynamics and recovery profile in patients requiring automatic internal cardioverter-defibrilator placement.</AbstractText>Prospective clinical investigation.</AbstractText>University hospital.</AbstractText>Thirty-fou...
2,110
[Acute hemodynamic effects of biventricular and left ventricular pacing in chronic pacemaker-dependent patients with advanced heart failure].
The beneficial hemodynamic effects of cardiac resynchronization in patients with intraventricular conduction delay have been demonstrated. The potential hemodynamic effects of cardiac resynchronization to compensate the pacing-induced left ventricular conduction delay in chronically paced heart failure patients are not...
2,111
Biphasic response of action potential duration to sudden sympathetic stimulation in anesthetized cats.
Although certain roles of the sympathetic nervous system have been suggested as possible mechanisms of life-threatening arrhythmias and sudden cardiac death, the dynamic electrophysiological response to sympathetic activation remains unclear. The aim of this study was to investigate the dynamic response of action poten...
2,112
Diabetes influences the cardiac symptoms related to atrial fibrillation.
It is well known that diabetes mellitus (DM) masks the cardiac symptoms during an ischemic heart attack, but there have not been reports of whether DM influences the subjective symptoms of atrial fibrillation (AF). The present study retrospectively assessed 65 patients who were revealed to be in sinus rhythm at their f...
2,113
Ischemia-induced translocation of protein kinase C-epsilon mediates cardioprotection in the streptozotocin-induced diabetic rat.
The present study investigated the role of translocation of protein kinase C (PKC) during ischemia/reperfusion in cardioprotection in the streptozotocin (STZ)-induced diabetic rat. Twelve weeks after injection of STZ or vehicle, male Wister-King rat hearts were isolated and perfused in the presence or absence of 50 nmo...
2,114
Refractoriness and conduction interaction during modulation of non-ischemic ventricular fibrillation by flecainide.
To study refractoriness and conduction interaction during modulation of non-ischemic ventricular fibrillation (VF) by flecainide.</AbstractText>Isolated feline and rabbit hearts were used. (a) In the feline hearts (n = 8), electrophysiological parameters were measured before and after flecainide administration (0.6, 1....
2,115
Clinical results with catheter ablation: AV junction, atrial fibrillation and ventricular tachycardia.
With the limitations of pharmacologic and device therapies for atrial fibrillation and ventricular tachycardia, catheter ablation is assuming a larger role in the management of patients with these common arrhythmias. Multiple case series and clinical trials have helped to define the evolving role of these techniques fo...
2,116
Rationale and patient selection for "hybrid" drug and device therapy in atrial and ventricular arrhythmias.
Three quite different forms of direct antiarrhythmic therapy are available for the treatment of cardiac arrhythmias: antiarrhythmic drugs, cardiac ablation and implantable devices (pacemakers and defibrillators). None of these therapies is fully effective and consequently they are increasingly combined. This combinatio...
2,117
Advances in devices for cardiac resynchronization in heart failure.
Patients with advanced heart failure have a high mortality and morbidity despite medical therapy. Depending on the underlying heart disease and severity of heart failure, 3.7 to 52.8% of patients have a QRS complex &gt; or =120 ms who may have interventricular and intraventricular dyssynchrony correctible by cardiac re...
2,118
Toward an understanding of the molecular mechanisms of ventricular fibrillation.
A major goal of basic research in cardiac electrophysiology is to understand the mechanisms responsible for ventricular fibrillation (VF). Here we review recent experimental and numerical results, from the ion channel to the organ level, which might lead to a better understanding of the cellular and molecular mechanism...
2,119
Clinical review of radiofrequency catheter ablation for cardiac arrhythmias.
Clinical tachycardias are a major cause of morbidity with detrimental effects on quality of life, physical activity and health care costs. Catheter ablation delivered by radiofrequency energy (RFA) has gradually expanded as a therapeutic modality for cure or palliation and is being adapted to address the most difficult...
2,120
Predictors of left atrial appendage stunning after electrical cardioversion of non-valvular atrial fibrillation.
To identify predictors of left atrial appendage stunning after the use of electrical cardioversion to restore sinus rhythm in patients with non-valvular atrial fibrillation.</AbstractText>A total of 68 consecutive patients (45 men, 23 women, 60.5 +/- 8.7 years of age) with non-valvular atrial fibrillation undergoing el...
2,121
Rising rates of hospital admissions for atrial fibrillation.
Atrial fibrillation is a common arrhythmia associated with excess morbidity and mortality. We studied temporal changes in hospital admission rates for atrial fibrillation using data from a prospective population-based cohort study spanning 2 decades (the Copenhagen City Heart Study).</AbstractText>The study included ba...
2,122
Anatomic stereotactic catheter ablation on three-dimensional magnetic resonance images in real time.
Targets for radiofrequency (RF) ablation of atrial fibrillation, atrial flutter, and nonidiopathic ventricular tachycardia are increasingly being selected on the basis of anatomic considerations. Because fluoroscopy provides only limited information about the relationship between catheter positions and cardiac structur...
2,123
Comparison of standard cardiopulmonary resuscitation versus the combination of active compression-decompression cardiopulmonary resuscitation and an inspiratory impedance threshold device for out-of-hospital cardiac arrest.
Active compression-decompression (ACD) CPR combined with an inspiratory impedance threshold device (ITD) improves vital organ blood flow during cardiac arrest. This study compared survival rates with ACD+ITD CPR versus standard manual CPR (S-CPR).</AbstractText>A prospective, controlled trial was performed in Mainz, Ge...
2,124
Sevoflurane reduces dysrhythmias during reperfusion in the working rat heart.
The effects of sevoflurane on myocardial reperfusion injury have not been well studied. The purpose of this study was to determine the effects of sevoflurane on myocardial function, arrhythmia, and metabolism during reperfusion in an isolated working rat heart model.</AbstractText>Thirty-two hearts were divided into fo...
2,125
Gender-related differences in morbidity and mortality during combined valve and coronary surgery.
Gender-related differences in morbidity and mortality are well described for coronary artery bypass grafting but are not well understood for combined valve and bypass surgery.</AbstractText>We reviewed retrospectively the morbidity and mortality of 1570 consecutive patients who underwent combined valve and bypass proce...
2,126
Clinical logistics in 24-hour ambulatory electrocardiographic monitoring.
In total, 493 ambulatory ECG recordings were studied. Women were preponderant (62.3% vs 37.7%). The average age of women and men patients was 66.9 and 64.7 years, respectively. Of the ECGs studied, 71.4% showed abnormalities and 28.6% appeared completely normal. Urgent abnormalities were noted in 1.4% of the recordings...
2,127
A neural mechanism for sudden death after myocardial infarction.
By monitoring efferent cardiac sympathetic nerve activity (CSNA) directly in a conscious animal we observed, for the first time, that ventricular fibrillation (VF) following myocardial infarction (MI) was preceded by a paroxysm of CSNA which was not baroreflexmodulated. This observation has potential therapeutic implic...
2,128
Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias.
This study was conducted to assess the safety and effectiveness of cardiac resynchronization therapy (CRT) when combined with an implantable cardioverter defibrillator (ICD).</AbstractText>Long-term outcome of CRT was measured in patients with symptomatic heart failure (HF), intraventricular conduction delay, and malig...
2,129
The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs.
Acute myocardial ischemia was induced by occluding the LAD in Clawn miniature pigs. Eight pigs (group 1) were subjected to 6 h ischemia and nine pigs (group 2) were subjected to 20 min ischemia, followed by reperfusion for 340 min. Three animals of the group 1 died due to ventricular fibrillation after occlusion and in...
2,130
Rhythm control versus rate control in patients with persistent atrial fibrillation. Results of the HOT CAFE Polish Study.
Patients with atrial fibrillation (AF) can be managed either by maintaining sinus rhythm using antiarrhythmic drugs and/or electrical cardioversion, or by leaving patients in AF and controlling ventricular rate without attempts to restore sinus rhythm. Which of these two strategies is superior, has not yet been definit...
2,131
Factors determining long-term maintenance of sinus rhythm after cardioversion of persistent atrial fibrillation.
Long-term maintenance of sinus rhythm (SR) after successful cardioversion (CV) of persistent atrial fibrillation (AF) carries a low risk of stroke and may avoid the risks associated with anticoagulation.</AbstractText>To determine the clinical and echocardiographic predictors of maintaining SR during one-year follow-up...
2,132
Admissions with atrial fibrillation in a multiracial population in Kuala Lumpur, Malaysia.
There are established differences in cardiovascular disease in different racial groups. Worldwide, the literature regarding the clinical epidemiology of atrial fibrillation in non-white populations is scarce.</AbstractText>To document the prevalence of atrial fibrillation (AF) in the multiracial population of Malaysia,...
2,133
Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study.
Despite the benefits associated with beta-blocker therapy in patients with acute myocardial infarction (AMI), limited recent data are available describing the extent of use of this therapy and the associated hospital and long-term outcomes, particularly from the perspective of a population-based study. Data are also li...
2,134
The high incidence of left atrial appendage thrombosis in patients on maintenance haemodialysis.
The incidence of intracardiac thrombosis in haemodialysis patients has not been studied. Here we determined the incidence in end-stage renal disease patients on maintenance haemodialysis.</AbstractText>Transoesophageal echocardiography was performed in 215 patients (125 males, 90 females; mean age 60 +/- 9 years). Any ...
2,135
A brief history of sudden cardiac death and its therapy.
At the end of the 19th century, there was both experimental and clinical evidence that coronary artery obstruction causes ventricular fibrillation and sudden death and that fibrillation could be terminated by electric shocks. The dominant figure at that time was McWilliam, who in 1923 complained that "little attention ...
2,136
Cardiac arrest due to ventricular fibrillation as a complication occurRing during rigid bronchoscopic laser therapy.
Laser bronchoscopy is a usually well tolerated procedure for the treatment of obstructive lesions on the tracheobronchial tree, with a very low morbidity and mortality rate. Cardiovascular complications, including atrial and ventricular arrhythmias, and myocardial ischemia, have only rarely been reported during laser b...
2,137
[Cardiac arrest and implantation of a cardioverter-defibrillator in a pregnant woman].
During pregnancy increased incidence of maternal cardiac arrhythmias is observed. We reported a 31 year old primipara after two incidents of cardiac arrest due to ventricular fibrillation during pregnancy at 10th and 16th week of gestation. The implantable cardioverter defibrillator was implanted at the 19th week of ge...
2,138
A candidate locus approach identifies a long QT syndrome gene mutation.
Long QT syndrome is an inherited disorder that results in lengthened cardiac repolarization. It can lead to sudden onset of torsades de pointes, ventricular fibrillation, and death. The authors obtained a family history, performed electrocardiograms, and drew blood for DNA extraction and genotyping from 15 family membe...
2,139
Cariporide is cardioprotective after iatrogenic ventricular fibrillation in the intact swine heart.
We sought to introduce sodium-hydrogen exchange inhibition as prophylaxis against the development of ventricular dysfunction in the setting of implantable cardioverter defibrillator insertion in high-risk patients. Cariporide, shown to be safe in humans, was used to reproduce previous results in our laboratory that dem...
2,140
Patient experiences with atrial fibrillation and treatment with implantable atrial defibrillation therapy.
Patient perspectives about their illness experiences, symptoms, and treatment are essential aspects of quality of life and provide direction for patient and provider decision making regarding innovative therapies such as implantable devices for arrhythmia.</AbstractText>The purpose of this qualitative study was to desc...
2,141
Transesophageal cardioversion of atrial flutter and atrial fibrillation using an electric balloon electrode system.
To determine the feasibility and efficiency of terminating atrial flutter (AFL) and atrial fibrillation (AF) using synchronous low-energy shocks delivered through a novel transesophageal electric balloon electrode system.</AbstractText>By using a novel electric balloon electrode system, we attempted 91 transesophageal ...
2,142
[Incidence and risk indicators of thromboembolism during the acute phase of single chamber ventricular pacing].
The incidence of thromboembolism may be higher in single chamber ventricular pacing than in physiological pacing. However, the incidence of thromboembolism during the acute phase of single chamber ventricular pacing (within 14 days) is not known.</AbstractText>The incidence and the risk indicators of thromboembolism we...
2,143
Detection of patients with hypertrophic cardiomyopathy at risk for paroxysmal atrial fibrillation during sinus rhythm by P-wave dispersion.
Paroxysmal atrial fibrillation (PAF) in hypertrophic cardiomyopathy (HCM) is associated with poor prognosis. Previous studies have shown good correlation between P-wave dispersion (Pd) and occurrence of PAF. However, Pd in patients with HCM for predicting PAF has not been studied.</AbstractText>The aim of the study was...
2,144
Biventricular support with the Jarvik 2000 axial flow pump: a feasibility study.
Patients with congestive heart failure who are supported with a left ventricular assist device (LVAD) may experience right ventricular dysfunction or failure that requires support with a right ventricular assist device (RVAD). To determine the feasibility of using a clinically available axial flow ventricular assist de...
2,145
Signal averaged ECG in different patterns of left ventricular hypertrophy and geometry in hypertension.
It is still unknown which factors determine the presence of ventricular late potentials (LP) in hypertension.</AbstractText>To evaluate the prevalence of LP in hypertension in relation to the pattern of left ventricular hypertrophy (LVH) and geometry, and to establish the factors causing signal-averaged ECG abnormaliti...
2,146
Heart rate variability in patients with Brugada syndrome in Thailand.
Since patients with Brugada syndrome usually have symptoms at nighttime, we hypothesize that changes in autonomic modulation have an important role in the occurrence of the ventricular fibrillation episodes. The objective of this study was to determine the changes in heart rate variability (HRV) in patients with Brugad...
2,147
Prediction of risk for first age-related cardiovascular events in an elderly population: the incremental value of echocardiography.
We sought to determine if echocardiography enhances prediction of first age-related cardiovascular events.</AbstractText>Whether echocardiographic assessment improves risk stratification for first cardiovascular events is not well known.</AbstractText>This retrospective cohort study included randomly selected residents...
2,148
Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors.
In rats subjected to myocardial ischemia/reperfusion, melanocortin peptides, including gamma(1)-melanocyte-stimulating hormone (gamma(1)-MSH), are able to exert a protective effect by stimulating brain melanocortin MC(3) receptors. A non-melanocortin receptor belonging to a group of receptors for Phe-Met-Arg-Phe-NH(2) ...
2,149
Spatiotemporal correlation between phase singularities and wavebreaks during ventricular fibrillation.
Phase Singularity and Wavebreak.</AbstractText>Phase maps and the detection of phase singularities (PSs) have become a well-developed method for characterizing the organization of ventricular fibrillation (VF). How precisely PS colocalizes with wavebreak (WB) during VF, however, is unknown.</AbstractText>We performed o...
2,150
Focal origin of atrial tachycardia in dogs with rapid ventricular pacing-induced heart failure.
Mapping and Ablation of Atrial Tachycardia in Heart Failure.</AbstractText>Dogs with rapid ventricular pacing-induced congestive heart failure (CHF) have inducible atrial tachycardia (AT), with a mechanism consistent with delayed afterdepolarization-mediated triggered activity. We assessed the hypothesis that AT has a ...
2,151
Effects of cytochalasin D on electrical restitution and the dynamics of ventricular fibrillation in isolated rabbit heart.
Cytochalasin D in Rabbit Ventricle.</AbstractText>Cytochalasin D (cyto-D) has been used as an excitation-contraction uncoupler during optical mapping studies. However, its effects on action potential duration restitution (APDR) and dynamics during ventricular fibrillation (VF) are unclear.</AbstractText>Langendorff-per...
2,152
Clinical significance and contributing factors of long-term variability in induced ventricular tachyarrhythmias.
Long-Term Variability in Induced Tachyarrhythmias.</AbstractText>Ventricular arrhythmias induced during electrophysiologic study (EPS) may vary over time, making arrhythmia induction studies unreliable. The aim of this prospective study was to clarify the clinical significance of long-term variability in induced arrhyt...
2,153
Distal right ventricular coil position reduces defibrillation thresholds.
Distal RV Coil Position Reduces DFTs.</AbstractText>Understanding the factors that affect defibrillation thresholds (DFTs) has important implications both for optimization of defibrillation efficacy and for the design of new transvenous leads. The aim of this prospective study was to test the hypothesis that defibrilla...
2,154
Automated external defibrillation versus manual defibrillation for prolonged ventricular fibrillation: lethal delays of chest compressions before and after countershocks.
We sought to determine whether the delays in chest compressions and defibrillation associated with an automated external defibrillator would adversely affect outcome compared with manual defibrillation in a swine model of out-of-hospital prolonged ventricular fibrillation.</AbstractText>After 8 minutes of untreated ven...
2,155
Rapid progression of primary cardiac leiomyosarcoma with obstruction of the left ventricular outflow tract and mitral stenosis.
We report a 73-year-old woman with primary cardiac leiomyosarcoma in the left atrium and ventricle. The tumor progressed very rapidly for 2 months after initial clinical evaluation. Obstruction of the left ventricular outflow tract and mitral stenosis were induced by the tumor. Urgent surgical resection was performed b...
2,156
Electrocardiogram in centenarians.
Electrocardiographic abnormalities in the very elderly have not yet been fully assessed.</AbstractText>To evaluate ECG recordings obtained from centenarians.</AbstractText>ECG tracings recorded at place of residence of 35 subjects aged 100-112 years (mean 101.7 years) were examined using the Minnesota code.</AbstractTe...
2,157
Atrial natriuretic peptide before and after cardioversion of persistent atrial fibrillation.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice, affecting many millions of people world-wide. The treatment of AF has improved significantly during the past decade, but most patients suffer from symptoms and recurrences of arrhythmia. Studies on the neurohormonal remodelli...
2,158
Efficacy of atrial antitachycardia pacing using the Medtronic AT500 pacemaker in patients with congenital heart disease.
Patients with congenital heart disease are vulnerable to atrial tachyarrhythmias, especially after atrial surgeries. We evaluated the efficacy of atrial arrhythmia detection and antitachycardia pacing (ATP) using the Medtronic AT500 pacemaker in 28 patients with congenital heart disease (age 30 +/- 18 years). Of 15 pat...
2,159
Usefulness of QRS prolongation in predicting risk of inducible monomorphic ventricular tachycardia in patients referred for electrophysiologic studies.
QRS prolongation on surface electrocardiography has been identified as a marker for increased cardiac mortality. A potential mechanism for increased mortality is ventricular tachycardia (VT). This study aimed to evaluate the relation between bundle branch block and sustained monomorphic VT inducibility in patients refe...
2,160
QRS duration and prediction of mortality in patients undergoing risk stratification for ventricular arrhythmias.
This study tested the hypothesis that prolonged QRS duration independently predicts long-term mortality in patients who underwent risk stratification and treatment for ventricular arrhythmias. Patients who underwent risk stratification by electrophysiologic study were identified. Electrophysiologic study results were d...
2,161
Endocardial defibrillation lead extraction: an unusual case of entrapment.
Spurious discharges due to late insulation break in an IS-1 pacing/sensing connector prompted ICD lead removal in 65-year-old man. The tip of the lead was easily freed and pulled back into the SVC by the superior approach. After that, the lead became trapped. The distal part of the lead was caught and easily withdrawn ...
2,162
Clinical efficacy of a wearable defibrillator in acutely terminating episodes of ventricular fibrillation using biphasic shocks.
The Wearable Cardioverter Defibrillator (WCD) automatically detects and treats ventricular tachyarrhythmias without the need for assistance from a bystander, while at the same time allowing the patient to ambulate freely. It represents an alternative to emergency medical services for outpatient populations with a tempo...
2,163
Predictors and clinical impact of atrial fibrillation after pacemaker implantation in elderly patients treated with dual chamber versus ventricular pacing.
The Pacemaker Selection in the Elderly (PASE) trial was a prospective, multicenter, single blind, randomized comparison of single chamber, rate adaptive, ventricular pacing (VVIR) with dual chamber, rate adaptive pacing (DDDR) in 407 patients aged &gt; or =65 years(mean 76 +/- 7 years, 60% male)with standard bradycardi...
2,164
Coingestion of cyclooxygenase inhibitors can worsen severe paracetamol poisoning by middle-sized and small arteries vasoconstriction.
We report fatal cases of multifocal ischemic injuries occurring in patients awaiting liver transplantation after severe concomitant paracetamol and cyclooygenase inhibitors self-poisoning.</AbstractText>Case report in an intensive care unit.</AbstractText>In addition to signs of acute liver failure with a systemic infl...
2,165
[Acquired long QT syndrome with torsade de pointes in a patient with primary hypothyroidism].
A case of 78 year-old woman with primary hypothyroidism and atrial fibrillation treated with sotalol, complicated with cardiac arrest due to ventricular fibrillation (VF) and torsade de pointes (TdP) is presented. The QT interval was prolonged to 660 msec. Episodes of polymorphic ventricular tachycardia and VF recurred...
2,166
Diagnosis of arrhythmogenic right ventricular dysplasia-cardiomyopathy: value of standard ECG revisited.
The diagnostic dilemma in arrhythmogenic right ventricular dysplasia-cardiomyopathy (ARVD/C) is that a single diagnostic test does not exist and that there is a need for broadening diagnostic criteria. As standard ECG contributes significantly to clinical diagnosis and represents a tool for screening in family studies ...
2,167
Predictive value of P-wave signal-averaged electrocardiogram for atrial fibrillation in acute myocardial infarction.
Atrial fibrillation (AF) is a common complication of acute myocardial infarction (AMI) with a reported incidence of 7-18%. Recently, P-wave signal-averaged electrocardiogram (P-SAECG) has been used to assess the risk of paroxysmal AF attacks in some diseases. The aim of this study was to determine prospectively whether...
2,168
Prevalence of sensing abnormalities in dual chamber implantable cardioverter defibrillators.
The clinical efficacy of ICD therapy depends on accurate sensing of intracardiac signals and sensing algorithms. We investigated the occurrence of sensing abnormalities in patients with dual chamber ICDs.</AbstractText>The study group consisted of all patients with dual chamber ICDs enrolled in the LESS trial and patie...
2,169
Management of hypertrophic cardiomyopathy in children.
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease characterized by unexplained left ventricular hypertrophy, typically involving the interventricular septum. Hypertrophy may be present in infants, but commonly develops during childhood and adolescence. Management of children with HCM aims to provide sym...
2,170
[18-year old patient with anti-epileptic therapy and sudden cardiac death].
An 18-year old female taking anti-epileptic medication was found unconscious in her bed early in the morning. After documented ventricular fibrillation and successful resuscitation, the patient was admitted to our emergency care unit. According to ECG criteria a long-QT syndrome of the subtype 2 was suspected. A few da...
2,171
Implantable cardioverter-defibrillators in cardiovascular care: technologic advances and new indications.
Present generation implantable cardioverter-defibrillators (ICD) have become a proven primary therapeutic option in management of symptomatic ventricular arrhythmias and are now being increasingly used for primary prevention. The addition of biventricular pacing and atrial defibrillation to these devices has had an imp...
2,172
Arrhythmias in the intensive care patient.
Atrial fibrillation, atrial flutter, AV-nodal reentry tachycardia with rapid ventricular response, atrial ectopic tachycardia, and preexcitation syndromes combined with atrial fibrillation or ventricular tachyarrhythmias are typical arrhythmias in intensive care patients. Most frequently, the diagnosis of the underlyin...
2,173
Electrical storm: case series and review of management.
Electrical storm is defined as a recurrent episode of hemodynamically destabilizing ventricular tachyarrhythmia that usually requires electrical cardioversion or defibrillation. We describe three cases presenting with electrical storm under differing circumstances: (1) a 57-year-old man with ST-elevation myocardial inf...
2,174
[Coronary artery bypass graft for patients with ascending aorta atherosclerosis].
The increasing number of aged patients with severe ascending aorta atherosclerosis who are undergoing coronary artery bypass graft (CABG) present high risk for ascending aortic cannulation, cross-clamping or partial occluding and proximal anastomosis. We reviewed the surgical experience in 22 patients of CABG with asce...
2,175
Paroxysms of excitement: sodium channel dysfunction in heart and brain.
Inherited disorders of ion-channels are associated with paroxysmal dysfunction of excitable tissues and manifest as diseases of the brain, heart and skeletal muscle. These so-called channelopathies have now been described for most of the major categories of voltage-dependent ion-channels including those selectively per...
2,176
Impact of cerebral cardiopulmonary resuscitation maneuvers in a general hospital: prognostic factors and outcomes.
To assess survival of patients undergoing cerebral cardiopulmonary resuscitation maneuvers and to identify prognostic factors for short-term survival.</AbstractText>Prospective study with patients undergoing cardiopulmonary resuscitation maneuvers.</AbstractText>The study included 150 patients. Spontaneous circulation ...
2,177
Pravastatin prevents arrhythmias induced by coronary artery ischemia/reperfusion in anesthetized normocholesterolemic rats.
HMG-CoA reductase inhibitors (statins) have been shown to decrease cardiovascular mortality. Since ventricular tachyarrhythmias are closely related to cardiovascular mortality, we tested effects of the hydrophilic statin pravastatin and the lipophilic statin fluvastatin in a rat arrhythmia model of ischemia/reperfusion...
2,178
Kv1.5 is an important component of repolarizing K+ current in canine atrial myocytes.
Although the canine atrium has proven useful in several experimental models of atrial fibrillation and for studying the effects of rapid atrial pacing on atrial electrical remodeling, it may not fully represent the human condition because of reported differences in functional ionic currents and ion channel subunit expr...
2,179
The hemodynamic and metabolic effects of shivering during acute normovolemic hemodilution.
To assess the hemodynamic and metabolic effects of shivering during extreme normovolemic hemodilution, we anesthetized 16 pigs with fentanyl-midazolam-pancuronium. Mild hypothermia (36.5 degrees +/- 0.1 degrees C) was induced by surface cooling, and the animals were randomized to either a control group (hemoglobin 118 ...
2,180
Anesthetic management for implantation of the Jarvik 2000 left ventricular assist system.
The Jarvik 2000 Heart(TM) is a left ventricular assist device that produces continuous nonpulsatile axial flow by means of a single, rotating, vaned impeller. Anesthetic and perioperative considerations of the Jarvik 2000 Heart(TM) differ from those of conventional assist devices. The Jarvik 2000 is implanted within th...
2,181
2-aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity.
A series of 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles was synthesized and tested for antiarrhythmic, local anaesthetic and analgesic activity. The title compounds showed a good antinociceptive activity.
2,182
Esmolol versus diltiazem in atrial fibrillation following coronary artery bypass graft surgery.
Atrial fibrillation (AF) is the most common arrhythmic complication following coronary artery bypass graft surgery (CABG). The efficacy and safety of esmolol and diltiazem were compared in patients with post-CABG AF.</AbstractText>This study was a retrospective medical record review of consecutive patients with post-CA...
2,183
[Implantable automatic defibrillator].
Automatic defibrillators which can be implanted have developed into a major advancement to treat patients suffering from cardiac arrhythmias, and especially cases of ventricular tachy-arrhythmias, which degenerate into ventricular fibrillation and can lead to cardiac arrest. Since tachy-arrhythmias can cause sudden, un...
2,184
A report of a surgical case of papillary fibroelastoma in the left ventricular outflow tract.
While a 74-year-old man with a past history of cerebral infarction was undergoing surface echocardiography due to transient atrial fibrillation, an unstable, pedunculated tumor was detected in the left ventricular outflow tract. As the results of transesophageal echocardiography suggested a left ventricular tumor, semi...
2,185
Effect of left ventricular function on long-term left ventricular pacing and sensing threshold.
The effect of left ventricular (LV) systolic function on the long-term left ventricular pacing and sensing threshold is unclear.</AbstractText>We studied the effect of LV ejection fraction (LVEF) on the LV pacing and sensing threshold in 56 patients (mean age: 70.2 +/- 10.5 years) underwent permanent LV pacing using a ...
2,186
Effectiveness of ibutilide in cardioversion of persistent atrial fibrillation in patients with dual chamber stimulation.
To evaluate the effectiveness of Ibutilide in cardioversion of persistent atrial fibrillation in patients with sinus node disease wearing a dual chamber pacemaker and to assess the potential role of overdrive ventricular pacing in prevention of drug related proarrhythmia.</AbstractText>Fifty-three sinus node disease pa...
2,187
QRS duration: a simple marker for predicting cardiac mortality in ICD patients with heart failure.
Patients resuscitated from ventricular tachyarrhythmias benefit from implantable cardioverter-defibrillators (ICDs) as opposed to medical treatment. Patients with increased QRS duration receiving an ICD in the presence of heart failure are at greatest risk of cardiac death and benefit most from ICD therapy.</AbstractTe...
2,188
Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy.
Hydroxyurea is a ribonucleotide diphosphate reductase inhibitor used in the treatment of patients with myeloproliferative disorders. Hydroxyurea has some dermatological side-effects. It has recently been recognized that hydroxyurea can induce squamous cell and basal cell carcinomas of skin. We present the case of an el...
2,189
Ventricular fibrillation in acute myocardial infarction in Spanish patients: Results of the ARIAM database.
The aim of this study has been to investigate the factors predisposing to primary or secondary ventricular fibrillation (VF) and the prognosis in Spanish patients with acute myocardial infarction (AMI) during their admission to the intensive care unit or the coronary care unit.</AbstractText>A retrospective, observatio...
2,190
Release of neuron-specific enolase and S100 after implantation of cardioverters/defibrillators.
Repeated induction of ventricular fibrillation with ensuing alterations in electroencephalogram and jugular venous oxygen saturation is common practice during insertion of transvenous implantable cardioverters/defibrillators. We investigated whether these functional changes are also associated with cerebral injury.</Ab...
2,191
Effect of lunar cycle on temporal variation in cardiopulmonary arrest in seven emergency departments during 11 years.
To determine the effect of the phase of the full and new moon on the variation in the number of daily cardiopulmonary resuscitations.</AbstractText>A retrospective analysis of a computerized billing database of emergency department visits in a cohort of seven northern New Jersey (USA) emergency departments.</AbstractTe...
2,192
Midterm results after stentless mitral valve replacement.
To analyze the midterm clinical results after stentless mitral valve (SMV) replacement.</AbstractText>Fifty one patients (68.3+/-8.4 years, 35 female) with severe mitral valve disease (stenosis 25, incompetence 17, mixed lesion 9) received a chordally supported SMV (Quattro, St. Jude Medical Inc.) since August 1997. Pr...
2,193
Results of the introduction of an automated external defibrillation programme for non-medical personnel in Galicia.
To describe the plan and development of a programme for the introduction of automated external defibrillation for non medical personnel and to report the results of the first 10 months of activity in a community which is predominently rural, such as Galicia.</AbstractText>The plan for introduction of the project includ...
2,194
Causes and prognosis of cardiac arrest in a population admitted to a general hospital; a diagnostic and therapeutic problem.
The purpose of this study was to determine the causes and the prognosis of consecutive patients resuscitated from cardiac arrest occurring in a general hospital. We assessed 28 females and 94 males (aged 13-82 years) who were resuscitated from cardiac arrest not attributable to acute myocardial infarction. Ventricular ...
2,195
Factors at resuscitation and outcome among patients suffering from out of hospital cardiac arrest in relation to age.
To describe various factors at resuscitation and outcome among patients suffering from out-of-hospital cardiac arrest in relation to age.</AbstractText>All patients included in the Swedish Cardiac Arrest Registry during the period 1990-1999. The registry covers about 60% of all ambulance organisations in Sweden.</Abstr...
2,196
Cardiopulmonary resuscitation of adults in the hospital: a report of 14720 cardiac arrests from the National Registry of Cardiopulmonary Resuscitation.
The National Registry of Cardiopulmonary Resuscitation (NRCPR) is an American Heart Association (AHA)-sponsored, prospective, multisite, observational study of in-hospital resuscitation. The NRCPR is currently the largest registry of its kind. The purpose of this article is to describe the NRCPR and to provide the firs...
2,197
EMS defibrillation-first policy may not improve outcome in out-of-hospital cardiac arrest.
Early defibrillation using automated external defibrillators (AEDs) has been advocated to improve survival in witnessed out-of-hospital cardiac arrest (OHCA) due to pulseless ventricular tachycardia (VT) and ventricular fibrillation (VF). However, when VT/VF is untreated and prolonged for more than a few minutes, defib...
2,198
The critical importance of minimal delay between chest compressions and subsequent defibrillation: a haemodynamic explanation.
Outcome after prehospital defibrillation remains dire. The aim of the present study was to elucidate the pathophysiology of cardiac arrest and to suggest ways to improve outcome. Ventricular fibrillation (VF) was induced in air-ventilated pigs, after which ventilation was withdrawn. After 6.5 min of VF, ventilation wit...
2,199
Management of unexpected coronary artery spasm in an asymptomatic patient during anaesthesia.
We report a case of life-threatening arrhythmia that was not predicted before surgery. Pulse-less ventricular tachycardia and ventricular fibrillation occurred during surgery without any changes in heart rate and blood pressure, and cardiac massage was required to maintain circulation. Although no organic stenosis was ...