Unnamed: 0
int64
0
2.34M
titles
stringlengths
5
21.5M
abst
stringlengths
1
21.5M
2,300
Diabetic atrial fibrillation patients: mortality and risk for stroke or embolism during a 10-year follow-up.
To compare in atrial fibrillation patients with and without diabetes, (1) baseline characteristics, (2) additional risk factors for stroke or peripheric or visceral embolism (hypertension, previous stroke, age &gt;75 years), (3) mortality, (4) stroke or embolism, and (5) oral anticoagulation in the year 2000.</Abstract...
2,301
Overcoming ACLS dogma: how quickly should we change?
The ECC Guidelines 2000 considered interesting new evidence about a pre-defibrillation period of prescribed CPR to increase the probability that the postshock rhythm would be perfusing rather than asystole. If victims of out-of-hospital cardiac arrest have not received bystander CPR before the arrival of the defibrilla...
2,302
R wave undersensing caused by an algorithm intended to enhance sensing specificity in an implantable cardioverter defibrillator.
This article reports on a case of ventricular undersensing despite normal R wave amplitudes during sinus rhythm in an ICD patient. Undersensing of ventricular signals was noted without any evidence of lead dislocation or variation in signal amplitude. Undersensing was due to an exceptionally small R wave signal width a...
2,303
Atrial fibrillation with a very rapid ventricular response as the first clinical arrhythmia in a 76-year-old man.
The interest of electrohysiological study for the prognostic evaluation of asymptomatic Wolff-Parkinson-White (WPW) syndrome remains controversial. We report the case of an asymptomatic 67-year-old man without heart disease in whom a type A WPW syndrome was noted. Because the WPW was unchanged during exercise testing, ...
2,304
Incidence and rate characteristics of atrial tachyarrhythmias in patients with a dual chamber defibrillator.
Atrial tachyarrhythmias play an important role in the treatment of patients with malignant ventricular tachyarrhythmias not only with respect to inappropriate discharges but also to left ventricular function and stroke risk. A combined dual chamber defibrillator provides separate therapies for atrial and ventricular ta...
2,305
A randomized prospective study of single coil versus dual coil defibrillation in patients with ventricular arrhythmias undergoing implantable cardioverter defibrillator therapy.
ICD implantation is standard therapy for malignant ventricular arrhythmias. The advantage of dual and single coil defibrillator leads in the successful conversion of arrhythmias is unclear. This study compared the effectiveness of dual versus single coil defibrillation leads. The study was a prospective, multicenter, r...
2,306
High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure.
The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF).</AbstractText>The patterns of activation within the PVs and the VOM during AF in CHF are unclear.</AbstractText>We induced CHF in nine dogs by rapid...
2,307
Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat.
The purpose of this study was to determine the pathogenic factors and molecular mechanisms involved in fibrosis of the atria.</AbstractText>Fibrosis is an important component of the pathophysiology of atrial fibrillation, especially when the arrhythmia is associated with heart failure (HF) or atrial dilation.</Abstract...
2,308
Complete heart block: determinants and clinical impact in patients with hypertrophic obstructive cardiomyopathy undergoing nonsurgical septal reduction therapy.
The purpose of this paper is to examine the incidence and determinants of permanent complete heart block (CHB) after nonsurgical septal reduction therapy (NSRT), and to evaluate the clinical impact of permanent pacemaker (PPM) placement.</AbstractText>Nonsurgical septal reduction therapy with ethanol improves the clini...
2,309
Blockade of the inward rectifying potassium current terminates ventricular fibrillation in the guinea pig heart.
Stable high-frequency rotors sustain ventricular fibrillation (VF) in the guinea pig heart. We surmised that rotor stabilization in the left ventricle (LV) and fibrillatory conduction toward the right ventricle (RV) result from chamber-specific differences in functional expression of inward rectifier (Kir2.x) channels ...
2,310
[Myocardial infarction in women: risk factors and clinical features].
The course of myocardial infarction (MI) in women, especially 60 years of age and older, is characterized by such severe complications as cardiorrhexis, hypovolemic cardiogenic shock, asystole, recurrent ventricular fibrillation and electromechanic dissociation responsible for the majority of lethal outcomes. Especiall...
2,311
The effect of short-term coronary perfusion using a perfusion apparatus on canine heart transplantation from non-heart-beating donors.
We investigated the effects of briefly perfusing hearts from non-heart-beating donors (NHBDs) with a Celsior solution before cardiac transplantation.</AbstractText>Donor hearts were left in situ for 20 minutes after cardiac arrest was induced by rapid exsanguination. Twelve donor-recipient pairs of mongrel dogs were di...
2,312
Hypertension and concurrent arrhythmias.
Hypertension and cardiac arrhythmias commonly coexist in many patients. In this review, we will initially discuss arrhythmogenesis in hypertension, with particular emphasis on atrial and ventricular tachyarrhythmias and sudden cardiac death, whilst in the final part, we will focus our attention on the effects of anti-h...
2,313
Radiofrequency catheter ablation for various tachyarrhythmias: experience in the Bangkok Heart Institute.
Radiofrequency catheter ablation (RFCA) is the first-line therapy for various tachyarrhythmias. The authors reports experience of RFCA for various types of tachyarrhythmia in 80 consecutive patients, 85 tracts of ablation, from May 2001 to October 2002. The mean age was 40 years, range 6-81 years. Seventy four and 13 t...
2,314
Life threatening ventricular arrhythmias with transient or correctable causes.
Traditionally, myocardial ischemia, electrolyte disorders, and proarrhythmic drug reactions have been considered transient and correctable causes of life threatening ventricular tachyarrhythmias. Recent evidence suggests that patients whose ventricular tachyarrhythmias are attributed to these "causes" have a poor outco...
2,315
Nineteen years' experience of out-of-hospital cardiac arrest in Gothenburg--reported in Utstein style.
To describe the outcome in the Utstein style for out of hospital cardiac arrest in Gothenburg, over a period of 19 years.</AbstractText>All consecutive cases of cardiac arrest between 1980 and 1999 in which the emergency medical service (EMS) system responded and attempted resuscitation were reported and followed up fo...
2,316
Success changes the problem: why ventricular fibrillation is declining, why pulseless electrical activity is emerging, and what to do about it.
Programs for research and practice in resuscitation have focused on identification and reversal of ventricular fibrillation (VF). While substantial progress has been achieved, evidence is accumulating that clinical death is less likely to be caused by fibrillation now than in the 1960s and 1970s. Pulseless electrical a...
2,317
A prospective, randomised and blinded comparison of first shock success of monophasic and biphasic waveforms in out-of-hospital cardiac arrest.
Evidence suggests that biphasic waveforms are more effective than monophasic waveforms for defibrillation in out-of-hospital cardiac arrest (OHCA), yet their performance has only been compared in un-blinded studies.</AbstractText>We compared the success of biphasic truncated exponential (BTE) and monophasic damped sine...
2,318
Biphasic and monophasic shocks for transthoracic defibrillation: a meta analysis of randomised controlled trials.
Biphasic waveforms are routinely used for implantable defibrillators. These waveforms have been less readily adopted for external defibrillation. This study was performed in order to evaluate the efficacy and harms of biphasic waveforms over monophasic waveforms for the transthoracic defibrillation of patients in ventr...
2,319
[Drug therapy of atrial fibrillation].
The authors summarize the up-to-date knowledge relating to the pharmacological treatment of atrial fibrillation. They emphasize that drug treatment continues to be in the forefront of the therapy of the arrhythmia, which can now be considered to constitute a cardiovascular epidemic. In the era following the Atrial Fibr...
2,320
Digoxin in heart failure and cardiac arrhythmias.
Digoxin therapy has no effect on mortality in heart failure. Digoxin may be useful for maintaining clinical stability and exercise capacity in patients with symptomatic heart failure. Digoxin appears to be of most benefit in patients with severe heart failure, cardiomegaly and a third heart sound. Digoxin should be use...
2,321
Clinical and transthoracic echocardiographic predictors of abnormal transesophageal findings in patients with suspected cardiac source of embolism.
Approximately 20% of cerebral infarctions are caused by a cardiac source of embolism. Although transesophageal echocardiography (TEE) is a valuable tool for evaluating patients with suspected cardioembolism, its use should be more selective.</AbstractText>We attempted to determine whether risk factors derived from the ...
2,322
Tissue discontinuities affect conduction velocity restitution: a mechanism by which structural barriers may promote wave break.
The mechanism by which structural barriers promote wave break and fibrillation is unclear. Conduction velocity (CV) restitution is an important determinant of wave break. Abnormal CV restitution is associated with ventricular fibrillation in patients with heart disease and arises preferentially in fibrotic myocardium. ...
2,323
Colour tissue velocity imaging can show resynchronisation of longitudinal left ventricular contraction pattern by biventricular pacing in patients with severe heart failure.
To quantify ventricular resynchronisation by biventricular pacing using colour tissue Doppler velocity imaging (c-TVI).</AbstractText>c-TVI shows regional tissue velocity profiles with a very high time resolution (10 ms). Eighteen patients were studied from an apical four chamber view at baseline and after a one month ...
2,324
Acute myocardial infarction: clinical and epidemiological profile and factors associated with in-hospital death in the municipality of Rio de Janeiro.
To study the factors associated with the risk of in-hospital death in acute myocardial infarction in the Brazilian public health system in Rio de Janeiro, Brazil.</AbstractText>Sectional study of a sample with 391 randomly drawn medical records of the hospitalizations due to acute myocardial infarction recorded in the ...
2,325
Simultaneous use of bilateral subthalamic nucleus stimulators and an implantable cardiac defibrillator. Case report.
Bilateral electrical stimulation of the subthalamic nucleus is being used with increasing frequency as a treatment for severe Parkinson disease (PD). Implantable cardiac defibrillators improve survival in certain high-risk patients with coronary artery disease and ventricular arrhythmias. Because of concern about possi...
2,326
[Coronary vasospasm during off-pump coronary artery bypass grafting; report of two cases].
Coronary vasospasm is one of the most dangerous and fatal complications of coronary artery bypass grafting (CABG) operation. Our experiences in recent 2 cases happened during off-pump CABG (OPCAB) are presented. Case 1: A 63-year-old male who had 3 vessels disease underwent OPCAB using left internal thoracic artery (LI...
2,327
A case series of sotalol-induced torsade de pointes in patients with atrial fibrillation--a tale with a twist.
Sotalol is a potent antiarrhythmic often used in patients with atrial fibrillation. However, it has been associated with a risk of provoking other potentially dangerous arrhythmias, especially if used in high doses and in patients with uncorrected electrolyte imbalance or impaired renal and cardiac function.</AbstractT...
2,328
[Treatment with implantable defibrillator].
About 20 years ago the first patient received an implantable cardioverter defibrillator (ICD), and since then the number of implants have increased dramatically. The ICD can terminate ventricular fibrillation and ventricular tachycardia. Studies of secondary prophylaxis show that ICD treatment can improve the prognosis...
2,329
[Diagnosis of narrow QRS complex tachycardias].
Tachycardias with normal QRS complexes (less than 0.12 seconds) may have multiple origins which may be classified in 4 groups: sinusal, atrioventricular nodal, atrioventricular junctional and finally, some ventricular tachycardias arising from near the conduction pathways. The electrocardiographic diagnosis requires an...
2,330
Incident cases of heart failure in a community cohort: importance and outcomes of patients with preserved systolic function.
The clinical presentation and outcomes of patients with heart failure and preserved systolic function have not been well characterized in the outpatient setting.</AbstractText>This was a retrospective cohort study of 403 patients with new-onset heart failure in a large regional health maintenance organization between J...
2,331
Mechanisms of sodium channel inactivation.
Rapid inactivation of sodium channels is crucial for the normal electrical activity of excitable cells. There are many different types of inactivation, including fast, slow and ultra-slow, and each of these can be modulated by cellular factors or accessory subunits. Fast inactivation occurs by a 'hinged lid' mechanism ...
2,332
Are lipid-lowering drugs also antiarrhythmic drugs? An analysis of the Antiarrhythmics versus Implantable Defibrillators (AVID) trial.
This study sought to evaluate the antiarrhythmic effects of lipid-lowering drug therapy as assessed by ventricular tachyarrhythmia (ventricular tachycardia [VT]/ventricular fibrillation [VF]) recurrences recorded by an implantable cardioverter defibrillator (ICD) in patients with atherosclerotic heart disease (ASHD).</...
2,333
Relationship between ST-segment morphology and conduction disturbances detected by signal-averaged electrocardiography in Brugada syndrome.
Although arrhythmogenesis of Brugada syndrome is still unknown, it has been reported to be associated with conduction disturbances. Two ST-segment morphologies (coved and saddle-back patterns) have been described in this syndrome. No study has sought to determine which morphology has stronger conduction disturbances, t...
2,334
Increased p-wave duration and p-wave dispersion in patients with aortic stenosis.
P-wave dispersion (PWD), defined as the difference between the maximum and minimum P-wave duration, has been proposed as being useful for the prediction of paroxysmal atrial fibrillation (AF). AF is the most common arrhythmia and an important prognostic indicator for clinical deterioration in patients with aortic steno...
2,335
Noninvasive risk stratification in arrhythmogenic right ventricular cardiomyopathy.
The natural history of arrhythmogenic right ventricular cardiomyopathy is determined by the electrical instability of the dystrophic myocardium, which can precipitate arrhythmic cardiac arrest any time during the course of the disease and by the progressive myocardial loss that results in ventricular dysfunction and he...
2,336
Effects of right coronary artery PTCA on variables of P-wave signal averaged electrocardiogram.
P-wave signal averaged ECG has been used to detect atrial late potentials that were found in paroxysmal atrial fibrillation. Ischemia is supposed to trigger ventricular late potentials, which indicate an elevated risk for ventricular tachycardia. Preexistent ventricular late potentials measured by ventricular signal av...
2,337
Effects of P-wave dispersion on atrial fibrillation in patients with acute anterior wall myocardial infarction.
P-wave dispersion (P dispersion), defined as the difference between the maximum and the minimum P-wave duration (P minimum), and maximum P-wave duration (P maximum) have been used to evaluate the discontinuous propagation of sinus impulse and the prolongation of atrial conduction time respectively. The aim of this stud...
2,338
Optimal timing for electrical defibrillation after prolonged untreated ventricular fibrillation.
It currently is recommended that electrical shocks be delivered immediately on recognition of ventricular fibrillation. However, decreased effectiveness of this approach has been reported after prolonged intervals of untreated ventricular fibrillation. We investigated the optimal strategy for successful defibrillation ...
2,339
Analysis of incidence of atrial fibrillation after implantation of VVI pacemaker--long-term observation of 154 patients.
Incidence of occurrence of atrial fibrillation (Af) after implantation of VVI was examined and the possible mechanism was explored. Eighty cases of atrioentricular block (AVB) and 74 cases of sick sinus syndrome (SSS) were studied and followed up for 1-14 years after implantation of VVI. The endpoint was the occurrence...
2,340
Ibutilide for pharmacological cardioversion of atrial fibrillation and flutter: impact of race on efficacy and safety.
To evaluate the racial differences in the efficacy and safety of ibutilide in patients with recent-onset (&lt;2 weeks) atrial fibrillation and atrial flutter.</AbstractText>This study included 58 consecutive patients with recent-onset atrial fibrillation (n = 34) and atrial flutter (n = 24). The mean age was 65.7 +/- 1...
2,341
Dofetilide: A new antiarrhythmic agent approved for conversion and/or maintenance of atrial fibrillation/atrial flutter.
Dofetilide is a new antiarrhythmic agent recently approved for the conversion of and maintenance of sinus rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFl). Dofetilide is a selective class III antiarrhythmic drug which works by selectively blocking the rapid component of the delayed rectifier ou...
2,342
Characteristics of Chinese patients with symptomatic Brugada syndrome in Taiwan.
Since 1992, the Brugada syndrome has been increasingly recognized worldwide, although its incidence and distribution remain unclear. In Asia, several cases have been reported in Japan, Thailand, Singapore, and Vietnam. However, little information is available from the Chinese population. Since June 1997, we have identi...
2,343
Unexplained syncope in patients with structural heart disease and no documented ventricular arrhythmias: value of electrophysiologically guided implantable cardioverter defibrillator therapy.
To evaluate electrophysiologically guided implantable cardioverter defibrillator (ICD) therapy in patients with syncope, structural heart disease and no documented sustained ventricular tachycardia (sVT).</AbstractText>Programmed ventricular stimulation (PVS) was performed in 52 patients (age 62+/-10 years): 40 patient...
2,344
Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo.
If lungs from patients dying of heart attacks are to serve as donor organs in a safe way, their function should be properly assessed before transplantation. The aim of this study was to investigate donor lung function evaluation in a realistic large animal model.</AbstractText>Twelve 60-kg pigs were used. Five minutes ...
2,345
Significant effects of atrioventricular node ablation and pacemaker implantation on left ventricular function and long-term survival in patients with atrial fibrillation and left ventricular dysfunction.
Control of ventricular rate by atrioventricular node ablation and pacemaker implantation in patients with drug-refractory atrial fibrillation (AF) is associated with improved left ventricular (LV) function. The objective of this study was to determine the effect of atrioventricular node ablation on long-term survival i...
2,346
Effect of elevated heart rate preceding the onset of ventricular tachycardia on antitachycardia pacing effectiveness in patients with implantable cardioverter defibrillators.
The incorporation of antitachycardia pacing (ATP) into implantable cardioverter defibrillators (ICDs) has provided a better tolerated alternative to shocks. ATP has been shown to be effective in terminating approximately 80% to 90% of spontaneous ventricular tachycardia (VT) episodes. Although ATP is routinely used, li...
2,347
[Value of genetic testing in the management of the congenital long QT syndrome].
The congenital long QT syndrome (LQTS) is a variable clinical and genetic entity characterised by prolongation of the QT interval on the ECG associated with the risk of serious ventricular arrhythmias (torsades de pointe, ventricular fibrillation) which may cause syncope and sudden death in patients with otherwise norm...
2,348
Role of nonsustained ventricular tachycardia and programmed ventricular stimulation for risk stratification in patients with idiopathic dilated cardiomyopathy.
The prognostic role of asymptomatic nonsustained ventricular tachycardia (NSVT) and programmed ventricular stimulation (PVS) in patients with idiopathic dilated cardiomyopathy (IDC) remains controversial.</AbstractText>The prognostic significance of ventricular arrhythmias, ejection fraction, NYHA class, atrial fibrill...
2,349
Single-beat determination of Doppler-derived aortic flow measurement in patients with atrial fibrillation.
The clinical assessment of left ventricular systolic function in patients with atrial fibrillation is unreliable and difficult because of beat-to-beat variation. We initially evaluated an index that is on the basis of the ratio of preceding R-R (RR1) to pre-preceding R-R (RR2) intervals (RR1/RR2) for the measurement of...
2,350
Proarrhythmic effect of pacemaker stimulation in patients with implanted cardioverter-defibrillators.
We sought to determine the potential of right ventricular VVI backup pacing to induce ventricular tachyarrhythmias in patients with implanted cardioverter-defibrillators.</AbstractText>All consecutive patients presenting exclusively with pacemaker-induced tachycardias (PITs) were included in a prospective study using a...
2,351
Spatial distribution of phase singularities in ventricular fibrillation.
Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)-locations of ambiguous activation state-underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS formation migh...
2,352
Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: implications for atrial fibrillation.
The substrates for the increased incidence of atrial fibrillation (AF) in hearts with chronic left ventricular myocardial infarction (MI) remain poorly defined. We hypothesized that chronic MI is associated with atrial electrical and neural remodeling that enhances AF vulnerability.</AbstractText>We created MI in 8 dog...
2,353
Cardiac Resynchronization Therapy for Advanced Heart Failure.
Cardiac resynchronization therapy (CRT) represents a new class of heart failure therapy that provides symptom relief and decreased need of hospitalization in a significant number of patients already receiving maximal medical intervention. Patients with ischemic or nonischemic dilated cardiomyopathy, coupled with interv...
2,354
Rate control in atrial fibrillation: choice of treatment and assessment of efficacy.
The clinical relevance and high social costs of atrial fibrillation have boosted interest in rate control as a cost-effective alternative to long-term maintenance of sinus rhythm (i.e. rhythm control). Prospective studies show that rate control (coupled with thromboembolic prophylaxis) is a valuable treatment option fo...
2,355
Resection of bronchopulmonary cancers invading the left atrium--benefit of cardiopulmonary bypass.
Cardiopulmonary bypass (CPB) for extended lung resections involving great vessels and other mediastinal organs remains controversial, especially due to CPB-related haemorrhagic and immunological issues. Here, we will retrospectively analyse the results obtained with such procedure.</AbstractText>Between January 1994 an...
2,356
Effects of irradiation on the components of implantable pacemakers.
The purpose of this study was to examine the effects of irradiation on implantable pacemaker components. The pacemaker was divided into three components: lead wire and electrode, battery, and electrical circuit, and each component was irradiated by X-ray and electron beams, respectively. The pacemaker parameters were m...
2,357
Utility of B-type natriuretic peptide (BNP) as a screen for left ventricular dysfunction in patients with diabetes.
Routine screening of diabetic patients with echocardiography is not feasible due to its limited availability and high cost. B-type natriuretic peptide (BNP) is secreted from the left ventricle in response to pressure overload and is elevated in both systolic and diastolic dysfunction.</AbstractText>BNP levels were comp...
2,358
Risk factors for recurrence of atrial fibrillation in patients undergoing hybrid therapy for antiarrhythmic drug-induced atrial flutter.
Catheter ablation of the inferior vena cava-tricuspid annulus isthmus and continuation of antiarrhythmic drug therapy have been shown to be an effective hybrid therapy for atrial flutter which results from antiarrhythmic drug treatment of atrial fibrillation. The aim of this study was to determine the risk factors for ...
2,359
Cardiac arrhythmias in the athlete: the evolving role of electrophysiology.
Arrhythmia management has undergone a revolution in the past decade. The diagnosis and treatment of arrhythmias in the athlete can be complicated by the need to compete and exercise. Some arrhythmias may be benign and asymptomatic, but others may be life threatening. Sinus bradyarrhythmias are common and even expected ...
2,360
Event and sideline management of sudden cardiac death.
The increasing use of automated external defibrillators (AEDs), coupled with methods to improve cardiopulmonary resuscitation and implementation of early defibrillation, have significantly improved survival from sudden cardiac death (SCD) in the prehospital setting. This article reviews the evidence and principles of m...
2,361
Is timing everything? Therapeutic potential of modulators of cardiac Na(+) transporters.
Sodium ion (Na(+)) transporters have roles in the modulation of cardiomyocyte pH and Na(+) and Ca(2+) handling. Activation of the cardiac Na(+)-H(+) exchanger 1 (NHE1) during ischaemia induces arrhythmias, myocardial stunning and irreversible cell injury. As the benefits of NHE1 inhibitors (e.g., amiloride, cariporide)...
2,362
Sodium-hydrogen exchange inhibition preserves ventricular function after ventricular fibrillation in the intact swine heart.
We tested the hypothesis that sodium-hydrogen exchange inhibition attenuates ventricular dysfunction after ischemia-reperfusion injury in the intact porcine heart.</AbstractText>Twelve pigs (weight, 30-45 kg) were evenly divided into 2 groups. Baseline ventricular function studies were based on echocardiography, conduc...
2,363
Amiodarone reduces the incidence of atrial fibrillation after coronary artery bypass grafting.
The purpose of this study was to evaluate the safety and efficacy of postoperative administration of prophylactic amiodarone in the prevention of new-onset postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.</AbstractText>In this prospective study 157 patients were randomly divided...
2,364
Transmyocardial laser revascularization: epicardial ECG detection provides efficient R-wave triggering during mobilization of the heart.
In order to achieve an accurate intraoperative ECG detection, a new technique in detecting the trigger-signal was developed. In contrast to the traditional three-lead ECG-configuration, the left leg electrode was connected to a transient epicardial pacemaker electrode on the left-ventricular surface.</AbstractText>The ...
2,365
Long-term outcomes of out-of-hospital cardiac arrest after successful early defibrillation.
Mortality after out-of-hospital cardiac arrest from ventricular fibrillation is high. Programs focusing on early defibrillation have improved the rate of survival to hospital discharge. We conducted a population-based analysis of the long-term outcome and quality of life of survivors.</AbstractText>All patients who had...
2,366
[Frequency and predictors of atrial fibrillation in severe mitral regurgitation].
The aim of this study was to assess the frequency and the predictive factors for atrial fibrillation (AF) in patients with severe mitral regurgitation (MR).</AbstractText>This study is a retrospective evaluation involving of 199 patients (100 females, 99 males, mean age 53.8+/-18.5) with severe MR who had been admitted...
2,367
A case of electrical storm in a liver transplant patient.
Electrical storm has not been well described in liver transplant patients. We present a case of sympathetically mediated recurrent ventricular fibrillation in a young patient transplanted for acute Wilson's disease. This case highlights the role of the sympathetic nervous system in causing electrical storm and it demon...
2,368
Retinal evaluation of patients on chronic amiodarone therapy.
To determine whether retinal electrophysiologic changes can be detected and correlated with funduscopic findings in patients with the long-term use of amiodarone.</AbstractText>Eleven patients ranging in age from 52 to 67 years were recruited from the Stanford University Medical Center Department of Cardiology for opht...
2,369
Predictors of residual tricuspid regurgitation after mitral valve surgery.
Whether preoperative tricuspid regurgitation (TR) will regress or progress late after surgery is unknown. The aim of this study was to evaluate predictors of significant TR late after mitral valve surgery.</AbstractText>A retrospective analysis was performed on a total of 174 patients who underwent mitral valve surgery...
2,370
Conversions in off-pump coronary surgery.
There have been 784 coronary artery bypass grafting (CABG) procedures performed at a new center for treating cardiovascular disease in Tuzla, Bosnia and Herzegovina, and the surgical team has been fully trained in offpump coronary artery bypass (OPCAB) surgery. All surgical patients were considered for on-pump CABG (ON...
2,371
Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study.
This study was designed to evaluate the ability of microvolt-level T-wave alternans (MTWA) to identify prospectively patients with idiopathic dilated cardiomyopathy (DCM) at risk of ventricular tachyarrhythmic events and to compare its predictive accuracy with that of conventional risk stratifiers.</AbstractText>Patien...
2,372
Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation.
The purpose of the present study was to evaluate the effect of angiotensin II type 1 receptor (AT1R) antagonist on chronic structural remodeling in atrial fibrillation (AF).</AbstractText>We previously reported that an AT1R antagonist, candesartan, prevents acute electrical remodeling in a rapid pacing model. However, ...
2,373
Familial atrial fibrillation is a genetically heterogeneous disorder.
The aims of this study were to identify and characterize familial cases of atrial fibrillation (AF) in our clinical practice and to determine whether AF is genetically heterogeneous.</AbstractText>Atrial fibrillation is not generally regarded as a heritable disorder, yet a genetic locus for familial AF was previously m...
2,374
[Detection of left ventricular ischemia at rest by tissue Doppler echocardiography].
A 53-year old woman without a previous history of cardiac disease was successfully resuscitated from ventricular fibrillation. Despite a normal two dimensional echocardiogram, tissue Doppler analysis of left ventricular long-axis contraction revealed marked postsystolic contractions in the territory of the left coronar...
2,375
The effects of nifedipine on ventricular fibrillation mean frequency in a porcine model of prolonged cardiopulmonary resuscitation.
We assessed the effects of a calcium channel blocker versus saline placebo on ventricular fibrillation mean frequency and hemodynamic variables during prolonged cardiopulmonary resuscitation (CPR). Before cardiac arrest, 10 animals were randomly assigned to receive either nifedipine (0.64 mg/kg; n = 5) or saline placeb...
2,376
The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats.
Intravascular injection of local anesthetics carries the risk of cardiovascular (CV) and central nervous system (CNS) toxicity. Amitriptyline, a tricyclic antidepressant, has local anesthetic potency that is more than that of bupivacaine. In this study, we compared the CV and CNS toxicity of the local anesthetics bupiv...
2,377
[Wolff-Parkinson-White syndrome in the child. A case report with associated atrial fibrillation].
In children, Wolff-Parkinson-White (WPW) syndrome is often revealed by reentrant tachycardia episodes. Rarely, this syndrome can be the cause of syncope or of sudden death, resulting from rapid conduction of atrial fibrillation to the ventricles through the accessory pathway.</AbstractText>The authors report the case o...
2,378
[Risk factors for stroke in Chinese with non valvular atrial fibrillation: a case-control study].
The aim of this study is to identify the risk factors in Chinese with nonvalvular atrial fibrillation and stroke, using case-control methodology.</AbstractText>A total of 4 511 adult patients diagnosed with atrial fibrillation were identified from 18 hospitals over a 2-year period. There were 1 086 patients with rheuma...
2,379
Prospective randomized comparison of 65%/65% versus 42%/42% tilt biphasic waveform on defibrillation thresholds in humans.
The waveform tilt of biphasic shocks yielding the lowest defibrillation threshold (DFT) is not well defined. Some evidence indicates that tilts less than 65% may improve DFTs.</AbstractText>In 57 patients undergoing ICD implantation, DFTs were determined with truncated exponential biphasic waveform tilts at 65%/65% and...
2,380
Is inappropriate implantable defibrillator shock therapy predictable?
To identify implantable cardioverter defibrillator (ICD) patients who are at risk of receiving inappropriate shock.</AbstractText>Inappropriate ICD shock, usually from atrial fibrillation (AF) or sinus tachycardia (ST), is a common problem. We hypothesized that clinical variables would predict which patients with singl...
2,381
Feasibility of atrial sensing via a free-floating single-pass defibrillation lead for dual-chamber defibrillators.
Detection and misclassification of rapidly conducted atrial fibrillation (AF) and marked sinus tachycardia by implantable cardioverter defibrillators (ICD) can result in the delivery of inappropriate therapies. Continuous atrial sensing may improve the differentiation between supraventricular and ventricular tachycardi...
2,382
Ablation of typical atrial flutter using a three-dimensional ultrasound mapping system.
The aim of the study was to test the feasibility of the new Realtime Position Management mapping system for ablation of typical atrial flutter.</AbstractText>The ultrasound multi-transducer catheters of the RPM Mapping System are placed in the coronary sinus and at the right ventricular apex. Position and movement of t...
2,383
[Update cardiology 2001/2002-part II. From unstable coronary syndrome to terminal heart failure].
The cardiovascular continuum describes the way from risk factors to atherosclerosis, acute cardiovascular events (unstable angina and myocardial infarction), and development of terminal heart failure and its complications. Following this way, advances are reported in the therapy of acute coronary syndrome, heart failur...
2,384
Determination of the upper limit of vulnerability using implantable cardioverter-defibrillator electrograms.
The upper limit of vulnerability (ULV) correlates with the defibrillation threshold and can be determined with 1 episode of ventricular fibrillation (VF). To automate the ULV in an implantable cardioverter-defibrillator (ICD), the most vulnerable intervals must be identified from an ICD electrogram rather than the late...
2,385
Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors.
We had previously reported that activation of histamine H(3)-receptors (H(3)R) on cardiac adrenergic nerve terminals decreases norepinephrine (NE) overflow from ischemic hearts and alleviates reperfusion arrhythmias. Thus, we used transgenic mice lacking H(3)R (H(3)R(-/-)) to investigate whether ischemic arrhythmias mi...
2,386
A critical evaluation of results of partial left ventriculectomy.
Because of the variation in the surgical procedures designed to reduce ventricular radius, along with differences in hospital care, it is difficult to disentangle the factors that may contribute to the success or failure of the partial left ventriculectomy.</AbstractText>We undertook partial left ventriculectomy in 18 ...
2,387
Partial left ventriculectomy (Batista's Procedure) case report: 40 months follow-up.
Partial left ventriculectomy (PLV) (also known as Batista's Procedure) is a surgical procedure for treatment of dilated cardiomyopathy when cardiac transplant is contraindicated. Mitral valve replacement is needed because of mitral regurgitation as a consequence of annulus enlargement and papillary muscle resection. Bl...
2,388
[Anticoagulation--control of heart rate--cardioversion. Therpeutic algorithm in ventricular tachycardia].
The first therapeutic step in the emergency situation absolute tachyarrhythmia in underlying atrial fibrillation is the immediate initiation of anticoagulation treatment with heparin, followed by control of the ventricular frequency. Cardioversion promises success when: atrial fibrillation &lt; 48 hours, transesophagea...
2,389
Heart failure complicated by atrial fibrillation: mechanistic, prognostic, and therapeutic implications.
Atrial fibrillation and congestive heart failure are two distinct clinical entities that are responsible for significant morbidity and mortality in the Western world. Hypertension, coronary artery disease, and nonischemic cardiomyopathy represent the most prevalent underlying pathologies of both diseases, implying a co...
2,390
Sudden death of a case of hypertrophic obstructive cardiomyopathy 19 months after successful percutaneous transluminal septal myocardial ablation.
A 56-year-old male with hypertrophic obstructive cardiomyopathy complicated with medically refractory paroxysmal atrial fibrillation and congestive heart failure was treated with percutaneous transluminal septal myocardial ablation. The resting left ventricular outflow tract gradient decreased from 70 mmHg to 0 mmHg af...
2,391
Autonomic imbalance as a property of symptomatic Brugada syndrome.
The autonomic properties in 27 patients with the electrocardiographic morphology of Brugada syndrome were investigated using 24-h Holter monitoring: 10 patients had a history of ventricular fibrillation (VF; Br-VF group) and 17 did not (Br-N group); there were 26 healthy subjects enrolled in this study. All subjects un...
2,392
Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion.
Adrenomedullin (AM) has been shown to protect against cardiac remodeling. In this study, we investigated the potential role of AM in myocardial ischemia-reperfusion (I/R) injury through adenovirus-mediated gene delivery. One week after AM gene delivery, rats were subjected to 30-min coronary occlusion, followed by 2-h ...
2,393
The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population.
To assess the prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in the chronically paced population.</AbstractText>Three hundred and seven patients were identified from attendance at routine pacemaker follow-up clinic. Subjects underwent a medical history and examination, 6-minute walk ...
2,394
Increased cortical cerebral blood flow by continuous infusion of adrenaline (epinephrine) during experimental cardiopulmonary resuscitation.
To study the effects of continuously administered adrenaline (epinephrine), compared to bolus doses, on the dynamics of cortical cerebral blood flow during experimental cardiopulmonary resuscitation (CPR), and after restoration of spontaneous circulation (ROSC).</AbstractText>Ventricular fibrillation was induced in 24 ...
2,395
Reverse CPR: a pilot study of CPR in the prone position.
Cardiopulmonary resuscitation (CPR), as described in 1960, remains the cornerstone of therapy for cardiopulmonary arrest. Recent case reports have described CPR in the prone position. We hypothesized rhythmic back pressure on a patient in the prone position with sternal counter-pressure (termed reverse CPR here) would ...
2,396
Safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications in patients with atrial fibrillation or atrial flutter.
We sought to establish the safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications (AAMs) for the maintenance of sinus rhythm in patients with atrial fibrillation (AF) or atrial flutter (AFl). AAMs are frequently utilized to maintain sinus rhythm in patients with AF or A...
2,397
The psychosocial impact of the implantable cardioverter defibrillator: a meta-analytic review.
The implantable cardioverter defibrillator (ICD) has become the treatment of choice for ventricular arrhythmia (VA; abnormal heart rhythms) and the prevention of sudden cardiac death (SCD). Recent clinical trials have shown the ICD to be superior to anti-arrhythmic medication in reducing mortality; however, research ha...
2,398
Decreased plasma brain natriuretic peptide levels after a successful maze procedure.
Previous reports indicate that plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) increase in atrial fibrillation (AF), but decrease after successful direct current (DC) cardioversion. Although the maze procedure is the only curative therapy for AF, the effects on atrial and left vent...
2,399
Effect of thyrotropin-releasing hormone on the development of cardiac arrhythmias during stimulation of sensorimotor cortex in cats.
Preliminary intravenous injection of thyrotropin-releasing hormone in a dose of 20 g/kg to cats with developing myocardial ischemia during stimulation of the cerebrocortical sensorimotor zone had a pronounced antiarrhythmic effect.