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2,326,400 | Molecular targets of chromatin repressive mark H3K9me3 in primate progenitor cells within adult neurogenic niches. | Histone 3 Lysine 9 (H3K9) methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3) is enriched in an adult neural stem cell niche- the subventricular zone (SVZ) on the walls of the lateral ventricle in both ro... |
2,326,401 | Endocardial left ventricular lead placement from the left subclavian vein approach. | In up to 10-15% of cases, the traditional epicardial approach for left ventricular (LV) lead placement is not feasible and surgical implantation is considered the alternative. We present the implantation of a transseptal LV lead through a left subclavian access.</AbstractText>Through the left subclavian vein access and... |
2,326,402 | Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome. | First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study we... |
2,326,403 | Human and monkey striatal interneurons are derived from the medial ganglionic eminence but not from the adult subventricular zone. | In adult rodent and monkey brains, newly born neurons in the subventricular zone (SVZ) in the wall of the lateral ventricle migrate into the olfactory bulb (OB) via the rostral migratory stream (RMS). A recent study reported that interneurons are constantly generating in the adult human striatum from the SVZ. In contra... |
2,326,404 | Systemic injection of CD34(+)-enriched human cord blood cells modulates poststroke neural and glial response in a sex-dependent manner in CD1 mice. | Stroke in the developing brain is an important cause of neurological morbidity. We determined the impact of human cord blood-derived CD34(+)-enriched mononuclear cells (CBSC) intraperitoneally injected 48 h after an ischemic stroke at postnatal day 12 by evaluating poststroke neurogenic niche proliferation, glia... |
2,326,405 | A novel protocol of continuous navigation guidance for endoscopic third ventriculostomy. | Although considered a standard neurosurgical procedure, endoscopic third ventriculostomy (ETV) is associated with a relatively high complication rate that is predominantly related to malpositioning of the trajectory.</AbstractText>To develop an advanced navigation protocol for ETV, assess its possible benefits over com... |
2,326,406 | Role of hemoglobin and iron in hydrocephalus after neonatal intraventricular hemorrhage. | Neonatal germinal matrix hemorrhage/intraventricular hemorrhage is common and often results in hydrocephalus. The pathogenesis of posthemorrhagic hydrocephalus is not fully understood.</AbstractText>To explore the potential role of hemoglobin and iron released after hemorrhage.</AbstractText>Artificial cerebrospinal fl... |
2,326,407 | [Gemella haemolysans brain abscess in a child with complex congenital heart disease]. | Gemella haemolysans, a Gram positive cocci which are deemed to be the normal inhabitant of the mucous membranes of the oropharynx, has been recognized as a pathogen involved in abscess formation. The aim of this case report is to demonstrate that it is also involved in brain abscess in children. We report, to our knowl... |
2,326,408 | Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure. | The molecular differences between ischemic (IF) and non-ischemic (NIF) heart failure are poorly defined. A better understanding of the molecular differences between these two heart failure etiologies may lead to the development of more effective heart failure therapeutics. In this study extensive proteomic and phosphop... |
2,326,409 | Interrogation of living myocardium in multiple static deformation states with diffusion tensor and diffusion spectrum imaging. | Diffusion tensor magnetic resonance imaging (MRI) reveals valuable insights into tissue histo-anatomy and microstructure, and has steadily gained traction in the cardiac community. Its wider use in small animal cardiac imaging in vivo has been constrained by its extreme sensitivity to motion, exaggerated by the hi... |
2,326,410 | Reversible cerebral periventricular white matter changes with corpus callosum involvement in acute toluene-poisoning. | Substance poisoning, such as toluene intoxication, has seldom been reported in the relevant literature. The documented cerebral neuroimaging has mostly described reversible symmetrical white matter changes in both the cerebral and cerebellar hemispheres. This paper presents 2 patients with toluene poisoning, whose brai... |
2,326,411 | Intraventricular human immunoglobulin distributes extensively but fails to modify amyloid in a mouse model of amyloid deposition. | Intravenous immunoglobulin infusions into Alzheimer patients have been found to provide cognitive benefit over a period of 6 mo in open label studies. One suggestion has been that these preparations contain small amounts of antibodies directed against monomeric and oligomeric Aβ which underlie their effectiveness... |
2,326,412 | Increased permeability of the blood-brain barrier and Alzheimer's disease-like alterations in slit-2 transgenic mice. | Alzheimer's disease (AD) is a progressive neurological disorder that primarily affects memory, and its prevalence is rising. Increasing evidence suggests that dysfunction of the blood-brain barrier (BBB) may be involved in AD and other neurodegenerative diseases. Herein, we report that the permeability of the BBB is in... |
2,326,413 | Simultaneous T1 and T2 quantification of the myocardium using cardiac balanced-SSFP inversion recovery with interleaved sampling acquisition (CABIRIA). | To develop a novel sequence for simultaneous quantification of T1 and T2 relaxation times in the myocardium based on the transient phase of the balanced steady-state free precession.</AbstractText>A new prototype sequence, named "cardiac balanced-SSFP inversion recovery with interleaved sampling acquisition" (CABIRIA) ... |
2,326,414 | Structural growth trajectories and rates of change in the first 3 months of infant brain development. | The very early postnatal period witnesses extraordinary rates of growth, but structural brain development in this period has largely not been explored longitudinally. Such assessment may be key in detecting and treating the earliest signs of neurodevelopmental disorders.</AbstractText>To assess structural growth trajec... |
2,326,415 | Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity. | In Parkinson's disease (PD) and other synucleinopathies, chronic neurodegeneration occurs within different areas of the central nervous system leading to progressive motor and nonmotor symptoms. The symptomatic treatment options that are currently available do not slow or halt disease progression. This highlights the n... |
2,326,416 | Dandy walker variant and bipolar I disorder with graphomania. | Cerebellum is known to play an important role in coordination and motor functions. In some resent studies it is also considered to be involved in modulation of mood, cognition and psychiatric disorders. Dandy Walker Malformation is a congenital malformation that is characterized by hypoplasia or aplasia of the cerebell... |
2,326,417 | Cardiac Hemangioma of RVOT in a Patient with Atypical Chest Pain. | A 40-year-old man presented with atypical chest pain and fatigue from 15 days ago a suspicious mass in the right ventricle based on a bed side transthoracic echocardiography. Preoperative diagnosis of a cardiac hemangioma comes to mind in a minority of cases. In our case, a cardiac tumor was diagnosed and the vascular ... |
2,326,418 | Two-dimensional speckle tracking echocardiography for the prediction of reversible myocardial dysfunction after acute myocardial infarction: comparison with magnetic resonance imaging. | We aimed to determine the predictive value of longitudinal, circumferential, and radial strains by two-dimensional speckle tracking echocardiography (2DSTE) for improvement in cardiac function after acute myocardial infarction (AMI) compared with that of contrast-enhanced cardiac magnetic resonance imaging (ceMRI).</Ab... |
2,326,419 | BMP5 expression in the adult rat brain. | Bone morphogenetic protein-5 (BMP5), a member of the transforming growth factor-β (TGF-β) superfamily, has many effects in several biological events. Although BMP5 expression has been well reported in the early development of the central nervous system (CNS), there is little information about its expression... |
2,326,420 | Pheromone-induced cell proliferation in the murine subventricular zone. | Enhancement of adult neurogenesis in female mice was previously demonstrated through exposure to soiled bedding from males, although the identity of relevant chemosignals has remained unknown. The farnesenes and SBT (2-sec-butyl-4,5-dihydrothiazole) are male murine pheromones that dominant males secrete at higher level... |
2,326,421 | Mediators involved in the hyperthermic action of neuromedin U in rats. | Neuromedin U (NmU), first was isolated from the porcine spinal cord, has subsequently been demonstrated in a number of species, in which it is present in the periphery and also the brain. Two receptors have been identified: NmU1R is mainly present in peripheral tissues, and Nmu2R in the central nervous system. NmU, a p... |
2,326,422 | The rescuable function and mechanism of resveratrol on As₂O₃-induced hERG K⁺ channel deficiency. | Arsenic trioxide (As2O3) is used to treat acute promyelocytic leukemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the human ether-a-go-go-related gene (hERG) current via disturbing its trafficking to cellular membrane. This study ai... |
2,326,423 | Technical strategies for the transcallosal transforaminal approach to third ventricle tumors: expanding the operative corridor. | There are a number of surgical approaches to the third ventricle, each with advantages and disadvantages. Which approach to use depends on the location of the lesion within the ventricle, the goals of the operation, and the surgeon's experience. The authors present their results in children with a modified approach thr... |
2,326,424 | A Giant Left Main Trunk and Left Circumflex Artery-to-Right Ventricle Fistula. | Coronary artery fistula including the left trunk and left circumflex is uncommon. We present a 24-year-old male patient with a giant left main trunk and left circumflex artery to right ventricle fistula, which is diagnosed by transthoracic echocardiography and coronary computed tomography angiography. In this paper, th... |
2,326,425 | Human FGF1 promoter is active in ependymal cells and dopaminergic neurons in the brains of F1B-GFP transgenic mice. | FGF1 is involved in multiple biological functions and exhibits the importance in neuroprotective effects. Our previous studies indicated that, in human brain and retina, the FGF1B promoter controlled the expression of FGF1. However, the exact function and regulation of FGF1 in brain is still unclear. Here, we generated... |
2,326,426 | Bilateral cysts in the choroid plexus in a patient with autosomal dominant polycystic kidney disease. | Autosomal dominant polycystic kidney disease (ADPKD) is a genetic systemic disorder, which is associated with cyst formation in several organs, renal function decline and a higher prevalence of intracranial aneurysms. We report a 52-year-old, otherwise healthy, man with ADPKD who had asymptomatic, bilateral, multiple c... |
2,326,427 | Pedunculated intraventricular subependymoma: Review of the literature and illustration of classical presentation through a clinical case. | Subependymomas are rare benign, noninvasive tumors, classified by the World Health Organization as low grade neoplasms. International data estimate their frequency between 0.2% and 0.7% of the intracranial tumors, and they usually are an incidental finding in autopsies. Preferably located in the fourth ventricle, these... |
2,326,428 | Blake's pouch cyst. | In 1900, Joseph Blake described a transient posterior evagination of the tela choroidea of the fourth ventricle in the normal 130-day old human embryo. He was the first to recognize and fully elucidate on the real nature of the foramen of Magendie as an aperture, which develops within a saccular expansion of the embryo... |
2,326,429 | Hindbrain glucoprivation effects on gastric vagal reflex circuits and gastric motility in the rat are suppressed by the astrocyte inhibitor fluorocitrate. | Fasting and hypoglycemia elicit powerful gastrointestinal contractions. Whereas the relationship between utilizable nutrient and gastric motility is well recognized, the explanation of this phenomenon has remained incomplete. A relatively recent controversial report suggested that astrocytes in the dorsal hindbrain may... |
2,326,430 | Multifunctional MR monitoring of the healing process after myocardial infarction. | Healing of the myocardium after infarction comprises a variety of local adaptive processes which contribute to the functional outcome after the insult. Therefore, we aimed to establish a setting for concomitant assessment of regional alterations in contractile function, morphology, and immunological state to gain progn... |
2,326,431 | Neonatal hyper- and hypothyroidism alter the myoglobin gene expression program in adulthood. | Myoglobin acts as an oxygen store and a reactive oxygen species acceptor in muscles. We examined myoglobin mRNA in rat cardiac ventricle and skeletal muscles during the first 42 days of life and the impact of transient neonatal hypo- and hyperthyroidism on the myoglobin gene expression pattern. Cardiac ventricle and sk... |
2,326,432 | Pilocytic astrocytoma with anaplastic features presenting good long-term clinical course after surgery alone: a case report. | Pilocytic astrocytomas (PAs) are the most common brain tumor in children and typically have an excellent prognosis. However, some PAs show histologically anaplastic features. It is reported that PAs with anaplastic features often need the postoperative radiation and chemotherapy due to aggressiveness such as early loca... |
2,326,433 | Filamin A mediated Big2 dependent endocytosis: From apical abscission to periventricular heterotopia. | Periventricular heterotopia (PH) is one of the most common malformations of cortical development (MCD). Nodules along the lateral ventricles of the brain, disruption of the ventricular lining, and a reduced brain size are hallmarks of this disorder. PH results in a disruption of the neuroependyma, inhibition of neural ... |
2,326,434 | A new tyrosine hydroxylase genotype with orofacial dyskinaesia. | Tyrosine hydroxylase (TH) deficiency is a rare autosomal recessive and often treatable neurometabolic disorder with variable phenotypes. More than 20 pathological mutations have been identified in patients with TH deficiency. We report the case of a 10-month-old male patient who presented with developmental delay, hypo... |
2,326,435 | Ozone-Oxidative Preconditioning Prevents Doxorubicin-induced Cardiotoxicity in Sprague-Dawley Rats. | Induced dilated cardiomyopathy is the main limitation of the anti-cancer drug doxorubicin, which causes oxidative stress and cardiomyocyte death. As ozone therapy can activate the antioxidant systems, this study aimed to investigate the therapeutic efficacy of ozone-oxidative preconditioning against doxorubicin-induced... |
2,326,436 | Image quality of iterative reconstruction in cranial CT imaging: comparison of model-based iterative reconstruction (MBIR) and adaptive statistical iterative reconstruction (ASiR). | The purpose of this study was to compare cranial CT (CCT) image quality (IQ) of the MBIR algorithm with standard iterative reconstruction (ASiR).</AbstractText>In this institutional review board (IRB)-approved study, raw data sets of 100 unenhanced CCT examinations (120 kV, 50-260 mAs, 20 mm collimation, 0.984 pitch) w... |
2,326,437 | Physiological electrical signals promote chain migration of neuroblasts by up-regulating P2Y1 purinergic receptors and enhancing cell adhesion. | Neuroblasts migrate as directed chains of cells during development and following brain damage. A fuller understanding of the mechanisms driving this will help define its developmental significance and in the refinement of strategies for brain repair using transplanted stem cells. Recently, we reported that in adult mou... |
2,326,438 | Visible Virchow-Robin spaces on magnetic resonance imaging of Alzheimer's disease patients and normal elderly from the Sunnybrook Dementia Study. | Visible Virchow-Robin spaces (VRS) are commonly used markers for small vessel disease in aging and dementia.</AbstractText>However, as previous reports were based on subjective visual ratings, the goal of this project was to validate and apply an MRI-based quantitative measure of VRS as a potential neuroimaging biomark... |
2,326,439 | New designs of ventricular catheters for hydrocephalus by 3-D computational fluid dynamics. | Based on a landmark study by Lin et al. of the two-dimensional flow in ventricular catheters (VCs) via computational fluid dynamics (CFD), we studied in a previous paper the three-dimensional flow patterns of five commercially available VC. We found that the drainage of the cerebrospinal fluid (CSF) mostly occurs throu... |
2,326,440 | Fetal myocardial wall area: constructing a reference range by means of spatiotemporal image correlation in the rendering mode. | To establish the reference range of the myocardial wall area in the fetus using three-dimensional ultrasound in the rendering mode.</AbstractText>A prospective, cross-sectional study including 371 singleton, uncomplicated pregnancies at 20 weeks 0 day to 33 weeks 6 days of gestation was carried out. Cardiac volumes wer... |
2,326,441 | Axon diameter and intra-axonal volume fraction of the corticospinal tract in idiopathic normal pressure hydrocephalus measured by q-space imaging. | Previous studies suggest that compression and stretching of the corticospinal tract (CST) potentially cause treatable gait disturbance in patients with idiopathic normal pressure hydrocephalus (iNPH). Measurement of axon diameter with diffusion MRI has recently been used to investigate microstructural alterations in ne... |
2,326,442 | Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats. | Changes in the heart compartments that leads to pathological cardiac hypertrophy can be related to testosterone reduction in aging males since heart cells are susceptible to androgens. Resistance exercise delays the changes of aging.</AbstractText>This study aimed to analyze alterations of the left ventricle of aged ra... |
2,326,443 | Levels of circulating anti-muscarinic and anti-adrenergic antibodies and their effect on cardiac arrhythmias and dysautonomia in murine models of Chagas disease. | SUMMARY Antibodies (Ab) recognizing G-protein coupled receptors, such as β 1 and β 2 adrenergic (anti-β 1-AR and anti-β 2-AR, respectively) and muscarinic cholinergic receptors (anti-M2-CR) may contribute to cardiac damage, however their role in chronic chagasic cardiomyopathy is still controver... |
2,326,444 | Interhemispheric Endoscopic Fenestration of the Lamina Terminalis through a Single Frontal Burr Hole. | Objective We evaluate the feasibility and safety of performing a novel interhemispheric endoscopic fenestration of the lamina terminalis (IEFLT) through a single frontal burr hole immediately lateral to the superior sagittal sinus. Methods Five cadaveric heads underwent IEFLT. Sequential burr holes were m... |
2,326,445 | Emergent surgical repair of left ventricular rupture after blunt chest trauma. | A 63-year-old man presented with sudden cardiac shock due to cardiac rupture after a blunt chest trauma. We emergently repaired 2 rupture sites with the sandwich technique. This technique maintained the ventricular geometry, and minimized impairment of cardiac function. |
2,326,446 | Heat stress attenuates new cell generation in the hypothalamus: a role for miR-138. | The anterior hypothalamus (Ant Hyp) of the brain serves as the main regulator of numerous homeostatic functions, among them body temperature. Fine-tuning of the thermal-response set point during the critical postnatal sensory-developmental period involves neuronal network remodeling which might also be accompanied by a... |
2,326,447 | Signaling through three chemokine receptors triggers the migration of transplanted neural precursor cells in a model of multiple sclerosis. | Multiple sclerosis (MS) is a multifocal disease, and precursor cells need to migrate into the multiple lesions in order to exert their therapeutic effects. Therefore, cell migration is a crucial element in regenerative processes in MS, dictating the route of delivery, when cell transplantation is considered. We have pr... |
2,326,448 | Adult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling. | Patients with glioblastoma multiforme (GBM) have an overall median survival of 15 months. This catastrophic survival rate is the consequence of systematic relapses that could arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. We previously demonstrated that GSCs are able to escape the tumor ... |
2,326,449 | Unique presentation of cerebellopontine angle choroid plexus papillomas: case report and review of the literature. | Objectives We present the case of a choroid plexus papilloma (CPP) in the cerebellopontine angle (CPA), describe the different appearances of CPPs with a variety of imaging techniques, and discuss the differential diagnosis of CPA tumors. Participant and Design We report the case of a 52-year-old woman wi... |
2,326,450 | In vitro study of the long-term cortisol treatment effects on the growth rate and proliferation of the neural stem/precursor cells. | Adult neural stem/precursor cells (NSPCs) residing in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus are involved in the memory formations and psychological problems. It is believed that basal levels of glucocorticoids are essential for neuronal develo... |
2,326,451 | Neuroprotective Effect of Transplanted Neural Precursors Embedded on PLA/CS Scaffold in an Animal Model of Multiple Sclerosis. | Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Cell transplantation may be an attractive therapeutic approach for MS which may promote remyelination and suppress the inflammatory process. Neural precursor cells are promising in transplantation strategies to trea... |
2,326,452 | Ventricular endoscopy in the pediatric population: review of indications. | Neuroendoscopy has greatly impacted pediatric neurosurgery over the past few decades. Improved optics and microsurgical tools have allowed neuroendoscopes to be used for a multitude of neurosurgical procedures.</AbstractText>In this review article, we present the breadth of intraventricular neuroendoscopic procedures f... |
2,326,453 | The foramen of Monro: a review of its anatomy, history, pathology, and surgery. | The foramen of Monro lies at the junction between the paired lateral ventricles and the third ventricle of the brain.</AbstractText>A comprehensive review of the literature was performed focusing on the foramen of Monro.</AbstractText>A good understanding of the anatomy of the foramen of Monro is essential for the neur... |
2,326,454 | Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction.<Pagination><StartPage>1101</StartPage><EndPage>1115</EndPage><MedlinePgn>1101-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1513/AnnalsATS.201312-425FR</ELocationID><Abstract><AbstractText>Pulmonary arterial ... | Pulmonary arterial hypertension (PAH) includes a heterogeneous group of diseases characterized by pulmonary vasoconstriction and remodeling of the lung circulation. Although PAH is a disease of the lungs, patients with PAH frequently die of right heart failure. Indeed, survival of patients with PAH depends on the adapt... |
2,326,455 | GLP-1 (7-36) amide restores myocardial insulin sensitivity and prevents the progression of heart failure in senescent beagles.<Pagination><StartPage>115</StartPage><MedlinePgn>115</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">115</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12933-014-0... | In patients with end-stage heart failure (HF), a total artificial heart (TAH) may be implanted as a bridge to cardiac transplant. However, in congenital heart disease (CHD), the malformed heart presents a challenge to TAH implantation. In the case presented here, a 17 year-old patient with congenital transposition of t... |
2,326,456 | Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood. | High alcohol consumption during pregnancy leads to deleterious effects on fetal cardiac structure and it also affects cardiomyocyte growth and maturation. This study aimed to determine whether low levels of maternal alcohol consumption are also detrimental to cardiomyocyte and cardiac growth in the early life of offspr... |
2,326,457 | Singular case of third ventricle metastasis of colorectal carcinoma--case report. | Third ventricle tumors are uncommon central nervous system lesions and unusual locations for metastatic colorectal cancer. We present a case of a 68 year old woman with a solitary 3rd ventricle lesion found on a computed tomography scan of the brain and the synchronous mass of the right colon. The aim in this case was ... |
2,326,458 | Malignant intraventricular meningioma with craniospinal dissemination and concurrent pulmonary metastasis. | Malignant intraventricular meningiomas are quite rare and may spread along the craniospinal axis or extraneurally. However, simultaneous cerebrospinal dissemination and distal extraneural metastasis has seldom been reported.</AbstractText>A 51-year-old woman presented with recurrent anaplastic meningioma in the trigone... |
2,326,459 | Vocal cord palsy anatomical changes and a foreign body mimicking malignancy. | A 74-year-old woman presented with a history of prolonged dysphonia, a red flag symptom for laryngeal cancer. Flexible nasal endoscopy revealed a lesion which looked suspicious for malignancy and therefore she went onto have a microlaryngoscopy and an attempt at biopsy. It was during this procedure that a foreign body ... |
2,326,460 | Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals. | We aimed to identify cerebrospinal fluid (CSF) biomarkers associated with neurodegeneration in individuals with and without CSF evidence of Alzheimer pathology. We investigated 287 Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects (age=74.9±6.9; 22/48/30% with Alzheimer's disease/mild cognitive impairmen... |
2,326,461 | Large Vestibular Schwannomas Presenting during Pregnancy: Management Strategies. | Objective Large vestibular schwannomas rarely present in pregnant women. Diagnosis and management of these tumors during pregnancy present a therapeutic challenge. Methods A 20-year-old primigravida woman at 26 weeks' gestation was transferred to our facility with gait imbalance, left facial weakness, lef... |
2,326,462 | Dyspnea and choking as presenting symptoms in primary medulla oblongata germinoma. | The medulla oblongata is the lower half of the brainstem. It contains the cardiac, respiratory, vomiting, and vasomotor centers and deals with autonomic functions such as breathing, heartbeat, and blood pressure. Primary medulla oblongata germinoma is very rare and less than 20 cases have been reported in the English l... |
2,326,463 | Optogenetic control of cardiomyocytes via viral delivery. | Optogenetics is an emerging technology for the manipulation and control of excitable tissues, such as the brain and heart. As this technique requires the genetic modification of cells in order to inscribe light sensitivity, for cardiac applications, here we describe the process through which neonatal rat ventricular my... |
2,326,464 | Differences in arterial stiffness and target organ damage between native Greek patients and immigrants from Eastern European countries with essential hypertension. | The variance in hypertension-related sequelae between different ethnic groups is highly related to differences in socioeconomic conditions and lifestyle habits, but also to disparities in the awareness and treatment of the disease. In the present study, we sought to evaluate the target organ damage in a vulnerable hype... |
2,326,465 | Cavernous hemangioma of the third ventricle: a case report and review of the literature. | Although cavernous hemangiomas (CHs) can be found anywhere in the central nervous system, CHs of the third ventricle have been reported in only 29 patients (including our case). In the current case report, we discuss the clinical characteristics and surgical outcome of CHs of the third ventricle.</AbstractText>A 64-yea... |
2,326,466 | [Localization and functions of the D-neuron: significance in pathogenesis of schizophrenia]. | The author proposes the "D-cell hypothesis" for molecular basis of the mesolimbic dopamine (DA) hyperactivity of schizophrenia. D-neurons, which were defined as "non-monoaminergic aromatic L-amino acid decarboxylase (AADC)-containing cells", produce trace amines (TAs), such as tyramine, phenylethylamine (PEA) and trypt... |
2,326,467 | [The behaviors of proliferative cells in the subventricular zone during cortical development].<Pagination><StartPage>131</StartPage><EndPage>136</EndPage><MedlinePgn>131-6</MedlinePgn></Pagination><Abstract><AbstractText>Recent studies revealed that the subventricular zone (SVZ) in the developing mammalian cerebrum is ... | Recent studies revealed that the subventricular zone (SVZ) in the developing mammalian cerebrum is a source of cortical neurons along with the ventricular zone (VZ), and especially in human SVZ, abundant self-renewal stem cells exist and are thought to largely contribute to the development of huge brain. These studies ... |
2,326,468 | Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury. | The objectives of this prospective study in 62 moderate-severe TBI patients were to investigate volume change in cortical gray matter (GM), hippocampus, lenticular nucleus, lobar white matter (WM), brainstem and ventricles using a within subject design and repeated MRI in the early phase (1-26 days) and 3 and... |
2,326,469 | Stem cell mechanisms during left ventricular remodeling post-myocardial infarction: Repair and regeneration. | Post-myocardial infarction (MI), the left ventricle (LV) undergoes a series of events collectively referred to as remodeling. As a result, damaged myocardium is replaced with fibrotic tissue consequently leading to contractile dysfunction and ultimately heart failure. LV remodeling post-MI includes inflammatory, fibrot... |
2,326,470 | A 10 year retrospective study of surgical outcomes of adult intracranial pilocytic astrocytoma. | Pilocytic astrocytomas (PA) are benign neoplasms commonly located in the cerebellum with a peak incidence in the first two decades of life. PA occurrence in adults is rare and very little information is available in the literature about tumour characteristics in this population. This study retrospectively identified 20... |
2,326,471 | Effects of antenatal hypoxia on tissue homeostasis in the myocardium of albino rats: early and delayed consequences. | Body weight, absolute and relative heart weight, DNA-synthetic activity of cardiomyocytes, and number of nucleoli in cardiomyocyte nuclei were reduced in newborn albino rats exposed to antennal hypoxia. All these changes developed against the background of oxidative stress. In mature animals, the absolute and relative ... |
2,326,472 | Attenuation of phosphorylated connexin-43 protein levels in diabetic rat heart by regular moderate exercise. | High blood glucose levels increase the ratio of phosphorylated to non-phosphorylated connexin-43 amounts, which leads to the decomposition of the hyperphosphorylated connexin-43. This can cause heart arrhythmia in diabetic patients. Considering the effective role of exercise in diabetic patients, and because there are ... |
2,326,473 | Cardiac myocyte sizes in right compared with left ventricle during overweight and hypertension. | Evidence is sparse concerning hypertrophy of cardiomyocytes in left and right ventricles (LV, RV). LV and RV from 105 forensic autopsies were weighed. Cross sectioned cardiac myocyte thicknesses were measured in hematoxylin and eosin-stained paraffin sections. Overweight (OW) is body weight >104.3 kg ... |
2,326,474 | Brachmann-Cornelia de Lange syndrome with a papilloma of the choroid plexus: analyses of molecular genetic characteristics of the patient and the tumor. A single-case study. | A 10-month-old girl with a Brachmann-Cornelia de Lange syndrome and a choroid plexus papilloma of the brain was studied at the Hospital Infantil de México Federico Gómez (HIMFG) in Mexico City.</AbstractText>Presumptive papilloma of the third ventricle was evidenced on CT and MR images and removed. Pathologic... |
2,326,475 | The Cushing response evoked by a fourth ventricular brainstem mass. | We report a case of a patient with a mass lesion of the pontomedullary junction with paroxysmal episodes of autonomic and other homeostatic dysfunction that echo the classic Cushing response to intracranial hypertension.<sup>1</sup> |
2,326,476 | Gene delivery in mouse auditory brainstem and hindbrain using in utero electroporation. | Manipulation of gene expression via recombinant viral vectors and creation of transgenic knock-out/in animals has revolutionized our understanding of genes that play critical roles during neuronal development and pathophysiology of neurological disorders. Recently, target-specific genetic manipulations are made possibl... |
2,326,477 | Sleep duration and age-related changes in brain structure and cognitive performance. | To investigate the contribution of sleep duration and quality to age-related changes in brain structure and cognitive performance in relatively healthy older adults.</AbstractText>Community-based longitudinal brain and cognitive aging study using a convenience sample.</AbstractText>Participants were studied in a resear... |
2,326,478 | Automatic computation of left ventricular volume changes over a cardiac cycle from echocardiography images by nonlinear dimensionality reduction. | Curve of left ventricular (LV) volume changes throughout the cardiac cycle is a fundamental parameter for clinical evaluation of various cardiovascular diseases. Currently, this evaluation is often performed manually which is tedious and time consuming and suffers from significant interobserver and intraobserver variab... |
2,326,479 | Morphological features and length measurements of fetal lateral ventricles at 16-25 weeks of gestation by magnetic resonance imaging. | Normal growth of the lateral ventricles (LVs) was characterized three-dimensionally using magnetic resonance imaging (MRI) data from 16 human fetuses at 16-25 weeks of gestation. The LV was differentiated into four primary regions, the anterior horn, central parts, posterior horn, and inferior horn, at 16 weeks of gest... |
2,326,480 | Left cerebral hemisphere and ventricular system abnormalities in a Mexican Meier Gorlin syndrome patient: widening the clinical spectrum. | The Meier-Gorlin syndrome (MGS) or ear, patella, short stature syndrome (MIM #224690) is a rare disorder with bilateral microtia, aplasia or hypoplasia of the patellae and severe intra-uterine and post-natal growth retardation. We report the case of a 10-year-old male with MGS diagnosis, his parents were related, he al... |
2,326,481 | [Ultrasound measurement of fetal posterior fossa at 11 to 13⁺⁶ gestational weeks for screening open spina bifida]. | To establish the normal reference ranges of transabdominal ultrasound measurements of the posterior fossa structure in fetuses at 11 to 13⁺⁶ gestational weeks and explore their clinical value in screening open spina bifida (OSB).</AbstractText>Between January, 2013 and September, 541 randomly selected nor... |
2,326,482 | Gender differences in the expression of genes involved during cardiac development in offspring from dams on high fat diet. | Previously we have demonstrated that maternal high fat diet (HF) during pregnancy increase cardiovascular risk in the offspring, and pharmacological intervention using statins in late pregnancy reduced these risk factors. However the effects of maternal HF-feeding and statin treatment during pregnancy on development of... |
2,326,483 | [Optimization of reconstruction parameters using a multi-focus fan beam collimator in myocardial perfusion single photon emission computed tomography study].<Pagination><StartPage>662</StartPage><EndPage>669</EndPage><MedlinePgn>662-9</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE">The aim of this stud... | The aim of this study was to optimize the reconstruction parameters for ordered subset conjugate gradient minimization (OSCGM) reconstruction using a multifocus fan beam collimator in myocardial perfusion single photon emission computed tomography (SPECT).</AbstractText>We attempted to validate the following performanc... |
2,326,484 | Endoscopic third ventriculostomy has no higher costs than ventriculoperitoneal shunt. | To evaluate the cost of endoscopic third ventriculostomy (ETV) compared to ventriculoperitoneal shunt (VPS) in the treatment of hydrocephalus in children.</AbstractText>We studied 103 children with hydrocephalus, 52 of which were treated with ETV and 51 with VPS in a prospective cohort. Treatment costs were compared wi... |
2,326,485 | Automatic classification of left ventricular wall segments in small animal ultrasound imaging. | Multiple statistics show that heart diseases are one of the main causes of mortality in our highly developed societies today. These diseases lead to a change of the physiology of the heart, which gives useful information about characteristic and severity of the defect. A fast and reliable diagnosis is the base for succ... |
2,326,486 | Whole-exome sequencing identifies a de novo TUBA1A mutation in a patient with sporadic malformations of cortical development: a case report. | Owing to the number of genetic mutations that contribute to malformations of cortical development, identification of causative mutations in candidate genes is challenging. To overcome these challenges, we performed whole-exome sequencing in this study.</AbstractText>A Japanese patient presented with microcephaly and se... |
2,326,487 | Post-mortem cardiac diffusion tensor imaging: detection of myocardial infarction and remodeling of myofiber architecture. | To investigate the accuracy of post-mortem diffusion tensor imaging (DTI) for the detection of myocardial infarction (MI) and to demonstrate the feasibility of helix angle (HA) calculation to study remodelling of myofibre architecture.</AbstractText>Cardiac DTI was performed in 26 deceased subjects prior to autopsy for... |
2,326,488 | [Three-dimensional visualization of the brain ependyma and tanycytes]. | The aim of this investigation was to develop an integrated approach to spatial reconstruction of the cells lining the ventricles of the brain using confocal laser microscopy and immunocytochemical reaction to vimentin. The work was performed on paraffin sections of rat brain of different thickness (5 and 10 microm). To... |
2,326,489 | [Structural features of cardiomyocytes in the atrialized right ventricle in patients with Ebstein anomaly].<Pagination><StartPage>13</StartPage><EndPage>16</EndPage><MedlinePgn>13-6</MedlinePgn></Pagination><Abstract><AbstractText>Intraoperative biopsy specimens were used to analyze the sizes and ultrastructure of card... | Intraoperative biopsy specimens were used to analyze the sizes and ultrastructure of cardiomyocytes (CMC) in the atrialized right ventricle (ARV) versus those in the right ventricle (RV) and right atrium (RA) in 32 patients aged 9 months to 57 years with Ebstein anomaly. The mean CMC diameter in ARV, RV, and RA did not... |
2,326,490 | An optimal decisional space for the classification of Alzheimer's disease and mild cognitive impairment. | This paper proposes to combine MRI data with a neuropsychological test, mini-mental state examination (MMSE), as input to a multi-dimensional space for the classification of Alzheimer's disease (AD) and it's prodromal stages-mild cognitive impairment (MCI) including amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The ... |
2,326,491 | Increased salt intake during early ontogenesis lead to development of arterial hypertension in salt-resistant Wistar rats. | A direct relationship exists between salt consumption and hypertension. Increased sodium intake does not automatically lead to a rise in blood pressure (BP) because of marked intra-individual variability in salt sensitivity. Wistar rats are a salt-resistant strain and increased salt intake in adults does not induce hyp... |
2,326,492 | Recurrent right ventricular takotsubo cardiomyopathy in a patient with recurrent aspiration. | Takotsubo cardiomyopathy is described as transient hypokinesis of the apical and mid-segments of the left ventricle with hypercontractile basal segments triggered by emotional or physical stress. Variants with basal hypokinesis and apical hyperkinesis have been described, as well as simultaneous involvement of the righ... |
2,326,493 | Structure and function of the ependymal barrier and diseases associated with ependyma disruption. | The neuroepithelium is a germinal epithelium containing progenitor cells that produce almost all of the central nervous system cells, including the ependyma. The neuroepithelium and ependyma constitute barriers containing polarized cells covering the embryonic or mature brain ventricles, respectively; therefore, they s... |
2,326,494 | Role of training and detraining on inflammatory and metabolic profile in infarcted rats: influences of cardiovascular autonomic nervous system. | The aim of this study was to evaluate the effects of exercise training (ET, 50-70% of VO2 max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n... |
2,326,495 | TRIP6 regulates neural stem cell maintenance in the postnatal mammalian subventricular zone. | Postnatal neurogenesis persists throughout life in the subventricular zone (SVZ)-olfactory bulb pathway in mammals. Extrinsic or intrinsic factors have been revealed to regulate neural stem cell (NSC) properties and neurogenesis. Thyroid hormone receptor interacting protein 6 (TRIP6) belongs to zyxin family of LIM prot... |
2,326,496 | Remote ischemic postconditioning alleviates cerebral ischemic injury by attenuating endoplasmic reticulum stress-mediated apoptosis. | Remote ischemic postconditioning (RIPostC) has been proved to protect the brain from stroke, but the precise mechanism remains not fully understood. In the present study, we aimed to investigate whether RIPostC attenuates cerebral ischemia-reperfusion injury by abating endoplasmic reticulum (ER) stress response. CHOP, ... |
2,326,497 | Excitotoxic brain injury in adult zebrafish stimulates neurogenesis and long-distance neuronal integration. | Zebrafish maintain a greater capacity than mammals for central nervous system repair after injury. Understanding differences in regenerative responses between different vertebrate species may shed light on mechanisms to improve repair in humans. Quinolinic acid is an excitotoxin that has been used to induce brain injur... |
2,326,498 | Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia. | The aim of this study is to evaluate cardiac function in fetuses with congenital diaphragmatic hernia (CDH) using speckle tracking.</AbstractText>Case-control study assessed cardiac contractility in consecutive fetuses with CDH. Controls were anatomically normal fetuses, adjusted for gestational age. Speckle tracking s... |
2,326,499 | Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus. | Defects in ependymal (E) cells, which line the ventricle and generate cerebrospinal fluid flow through ciliary beating, can cause hydrocephalus. Dishevelled genes (Dvls) are essential for Wnt signaling, and Dvl2 has been shown to localize to the rootlet of motile cilia. Using the hGFAP-Cre;Dvl1(-/-);2(flox/flox);3(+/-)... |
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