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2,326,700 | Retinoic acid induced-1 (Rai1) regulates craniofacial and brain development in Xenopus. | Retinoic acid induced-1 (RAI1) is an important yet understudied histone code reader that when mutated in humans results in Smith-Magenis syndrome (SMS), a neurobehavioral disorder accompanied by signature craniofacial abnormalities. Despite previous studies in mouse and human cell models, very little is known about the... |
2,326,701 | Gamma Knife surgery for arteriovenous malformations within or adjacent to the ventricles. | The outcomes of stereotactic radiosurgery for arteriovenous malformations (AVMs) within or adjacent to the ventricular system are largely unknown. This study assessed the long-term outcomes and hemorrhage risks for patients with AVMs within this region who underwent Gamma Knife surgery (GKS) at the University of Pittsb... |
2,326,702 | Effects of hypertension and exercise on cardiac proteome remodelling. | Left ventricle hypertrophy is a common outcome of pressure overload stimulus closely associated with hypertension. This process is triggered by adverse molecular signalling, gene expression, and proteome alteration. Proteomic research has revealed that several molecular targets are associated with pathologic cardiac hy... |
2,326,703 | Swimming exercise ameliorates multiple sclerosis-induced impairment of short-term memory by suppressing apoptosis in the hippocampus of rats. | Multiple sclerosis is one of the autoimmune diseases in the central nervous system. Multiple sclerosis occurs through multiple mechanisms, and it is also mediated in part by an apoptotic mechanism. Swimming exercise has been recommended for the prevention and treatment of chronic diseases. In the present study, we inve... |
2,326,704 | Optical assessment of the cardiac rhythm of contracting cardiomyocytes in vitro and a pulsating heart in vivo for pharmacological screening. | Our quest in the pathogenesis and therapies targeting human heart diseases requires assessment of the contractile dynamics of cardiac models of varied complexity, such as isolated cardiomyocytes and the heart of a model animal. It is hence beneficial to have an integral means that can interrogate both cardiomyocytes in... |
2,326,705 | Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model. | Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. This study evaluated how intravenous ferric carboxymaltose (FCM) modulates the influence o... |
2,326,706 | Adult idiopatic occlusion of Monro foramina: intraoperative endoscopic reinterpretation of radiological data and review of the literature. | Adult idiopathic occlusion of the foramen of Monro (AIOFM) is a rare condition, with only few cases described in the modern literature. We propose that AIOFM may result from unilateral or bilateral occlusion of Monro foramina, as well as from progression of a monolateral hydrocephalus. Different surgical strategies may... |
2,326,707 | Interhypothalamic adhesion: a series of 13 cases. | Interhypothalamic adhesion is a newly described disease entity, characterized by an abnormal parenchymal band connecting the medial margins of the hypothalami across the third ventricle. Additional anomalies, including cleft palate, gray matter heterotopia, cerebellar hypoplasia, optic atrophy, hippocampal under-rotati... |
2,326,708 | Neuroendoscopy and high-field intraoperative MRI: first experience. | To date, information about the use of intraoperative MRI (iMRI) in patients undergoing neuroendoscopic procedures is sparse. The benefit may be (re)definition of neuronavigation, confirmation of fenestrations and biopsies, detection of complications, and redefinition of anatomical changes during the operation.</Abstrac... |
2,326,709 | The small-chamber irrigation technique (SCIT): a simple maneuver for managing intraoperative hemorrhage during endoscopic intraventricular surgery. | Acute intraoperative intraventricular hemorrhage is a feared event in endoscopic neurosurgical procedures.</AbstractText>To describe the small-chamber irrigation technique (SCIT) for intraoperative endoscopic management of intraventricular hemorrhage.</AbstractText>The SCIT was used in intraventricular surgery for hydr... |
2,326,710 | Distribution and histopathological changes induced by cysts of Taenia solium in the brain of pigs from Tanzania. | Neurocysticercosis (NCC) caused by Taenia solium cysts is a frequent but neglected parasitic disease of the central nervous system (CNS) worldwide. The aim of this study was to describe anatomical locations of cysts in the CNS and the corresponding inflammation. A total of 17 naturally infected pigs were used to evalua... |
2,326,711 | Clinical and magnetic resonance imaging characteristics of tubercular ventriculitis: an under-recognized complication of tubercular meningitis. | Ventriculitis also referred as ependymitis or ventricular empyema is a known complication of pyogenic meningitis. Despite high incidence of tubercular meningitis in developing countries, there are hardly any reports of tubercular ventriculitis.</AbstractText>Five patients (four males and one female) of tubercular ventr... |
2,326,712 | Automated interventricular septum segmentation for black-blood myocardial T2* measurement in thalassemia. | To develop and validate an automated segmentation method that extracts the interventricular septum (IS) from myocardial black-blood images for the T2* measurement in thalassemia patients.</AbstractText>A total of 144 thalassemia major patients (age range, 11-51 years; 73 males) were scanned with a black-blood multi-ech... |
2,326,713 | Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. | We recently reported that young (3 to 4months old) mice lacking Exon 1 of the Smad7 gene (S7ΔEx1 mice) show enhanced proliferation of neural stem and progenitor cells (NPCs) in the hippocampal dentate gyrus (DG) and in the subventricular zone (SVZ) of the lateral ventricles. It remained unclear, however, whether ... |
2,326,714 | A rare case of racemose neurocysticercosis of the posterior fossa. | A 43-year-old man presented with a 3 month history of headache, vertigo and swaying while walking. MRI of the brain showed cystic lesions involving the cerebellopontine angle cisterns, the right perimedullary cistern, the fourth ventricle and bilateral foramen of Luschka with resultant obstruction to cerebrospinal flui... |
2,326,715 | Gene Deletion of VIP Leads to Increased Mortality Associated with Progressive Right Ventricular Hypertrophy. | Vasoactive Intestinal Peptide (VIP) knockout mice exhibit asthma, pulmonary hypertension, and left ventricular wall thinning. Humans with these disorders have premature death. We show here that VIP KO mice have reduced survival (100% mortality at 20 months), <i>vs.</i> 100% survival among WT C57BL/6 mice. Moreover, the... |
2,326,716 | Three-Class Differential Diagnosis among Alzheimer Disease, Frontotemporal Dementia, and Controls. | Biomarkers derived from brain magnetic resonance (MR) imaging have promise in being able to assist in the clinical diagnosis of brain pathologies. These have been used in many studies in which the goal has been to distinguish between pathologies such as Alzheimer's disease and healthy aging. However, other dementias, i... |
2,326,717 | Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury. | Melusin is a muscle-specific protein which interacts with β1 integrin cytoplasmic domain and acts as chaperone protein. Its overexpression induces improved resistance to cardiac overload delaying left ventricle dilation and reducing the occurrence of heart failure. Here, we investigated possible protective effect... |
2,326,718 | Ultrasound backscatter tensor imaging (BTI): analysis of the spatial coherence of ultrasonic speckle in anisotropic soft tissues. | The assessment of fiber architecture is of major interest in the progression of myocardial disease. Recent techniques such as magnetic resonance diffusion tensor imaging (MR-DTI) or ultrasound elastic tensor imaging (ETI) can derive the fiber directions by measuring the anisotropy of water diffusion or tissue elasticit... |
2,326,719 | Long-term hydrocephalus alters the cytoarchitecture of the adult subventricular zone. | Hydrocephalus can develop secondarily to a disturbance in production, flow and/or absorption of cerebrospinal fluid. Experimental models of hydrocephalus, especially subacute and chronic hydrocephalus, are few and limited, and the effects of hydrocephalus on the subventricular zone are unclear. The aim of this study wa... |
2,326,720 | Utility of computed tomography or magnetic resonance imaging evaluation of ventricular morphology in suspected cerebrospinal fluid shunt malfunction. | It is common to evaluate children with suspected CSF shunt malfunctions using CT of the head or, more recently, "quick brain" MRI. However, the reliability of using ventricular behavior, as assessed on cranial imaging during previous presentations with shunt obstructions, is not well defined. The authors conducted a st... |
2,326,721 | Anatomy of the pineal region applied to its surgical approach. | The pineal region is situated in the posterior part of the incisural space. This region includes the pineal body inside the quadrigeminal arachnoidal cistern. This article reviews the anatomic features of this region, with particular emphasis on those aspects of importance for surgical access to the pineal region.</Abs... |
2,326,722 | Characterization of the connexin45 carboxyl-terminal domain structure and interactions with molecular partners. | Mechanisms underlying the initiation and persistence of lethal cardiac rhythms are of significant clinical and scientific interests. Gap junctions are principally involved in forming the electrical connections between myocytes, and changes in distribution, density, and properties are consistent characteristics in arrhy... |
2,326,723 | Reproducible deep-inspiration breath-hold irradiation with forward intensity-modulated radiotherapy for left-sided breast cancer significantly reduces cardiac radiation exposure compared to inverse intensity-modulated radiotherapy. | To investigate the objective utility of our clinical routine of reproducible deep-inspiration breath-hold irradiation for left-sided breast cancer patients on reducing cardiac exposure.</AbstractText>Free-breathing and reproducible deep-inspiration breath-hold scans were evaluated for our 10 consecutive left-sided brea... |
2,326,724 | STRA6 is critical for cellular vitamin A uptake and homeostasis. | Vitamin A must be adequately distributed within the body to maintain the functions of retinoids in the periphery and chromophore production in the eyes. Blood transport of the lipophilic vitamin is mediated by the retinol-binding protein, RBP4. Biochemical evidence suggests that cellular uptake of vitamin A from RBP4 i... |
2,326,725 | Effect of assisted reproductive technology on fetal brain development assessed by prenatal ultrasonography. | The aim was to evaluate whether assisted reproductive technology (ART) affects the development of the fetal central nervous system (CNS).</AbstractText>This study was carried out on women with singleton pregnancies, including 427 women who became pregnant by ART and 32,859 women with natural conceptions (NCs). The cavu... |
2,326,726 | Tracking using motion estimation with physically motivated inter-region constraints. | We propose a method for tracking structures (e.g., ventricles and myocardium) in cardiac images (e.g., magnetic resonance) by propagating forward in time a previous estimate of the structures using a new physically motivated motion estimation scheme. Our method estimates motion by regularizing only within structures so... |
2,326,727 | Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations. | Prostatic acid phosphatase (PAP), the first diagnostic marker and present therapeutic target for prostate cancer, modulates nociception at the dorsal root ganglia (DRG), but its function in the central nervous system has remained unknown. We studied expression and function of TMPAP (the transmembrane isoform of PAP) in... |
2,326,728 | Pituitary adenylate cyclase-activating polypeptide (PACAP) in the bed nucleus of the stria terminalis (BNST) increases corticosterone in male and female rats. | Single nucleotide polymorphisms (SNP) in the genes for pituitary adenylate cyclase-activating polypeptide (PACAP) and the PAC1 receptor have been associated with several psychiatric disorders whose etiology has been associated with stressor exposure and/or dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis.... |
2,326,729 | Wireless power transfer to deep-tissue microimplants. | The ability to implant electronic systems in the human body has led to many medical advances. Progress in semiconductor technology paved the way for devices at the scale of a millimeter or less ("microimplants"), but the miniaturization of the power source remains challenging. Although wireless powering has been demons... |
2,326,730 | Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. | Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast(mid)EGFR... |
2,326,731 | Aerobic exercise inhibits sympathetic nerve sprouting and restores β-adrenergic receptor balance in rats with myocardial infarction. | Cardiac sympathetic nerve sprouting and the dysregulation of β-adrenergic receptor (β-AR) play a critical role in the deterioration of cardiac function after myocardial infarction (MI). Growing evidence indicates that exercise provides protection against MI. The aims of this study were to investigate whethe... |
2,326,732 | [Treatment of lesions in mesencephalic aqueduct and around it by neuroendoscope]. | To explore the surgical efficacy of lesions in mesencephalic aqueduct and around it with neuroendoscope.</AbstractText>A total of 14 cases with lesion underwent neuroendoscope. Endoscopic third ventriculostomy (ETV), excision or biopsy and mesencephalic aqueduct plasty were performed.</AbstractText>There were primary o... |
2,326,733 | Sexual differences in cell proliferation in the ventricular zone, cell migration and differentiation in the HVC of juvenile Bengalese finch. | Song control nuclei have distinct sexual differences and thus are an ideal model to address how brain areas are sexually differentiated. Through a combination of histological analysis and electrical lesions, we first identified the ventricle site for HVC progenitor cells. We then found that there were significant sex d... |
2,326,734 | Interplay between arterial stiffness and diastolic function: a marker of ventricular-vascular coupling.<Pagination><StartPage>788</StartPage><EndPage>796</EndPage><MedlinePgn>788-96</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2459/JCM.0000000000000093</ELocationID><Abstract><AbstractText Label="A... | Neurons of the cerebral cortex are generated during brain development from different types of neural stem and progenitor cells (NSPC), which form a pseudostratified epithelium lining the lateral ventricles of the embryonic brain. Genotoxic stresses, such as ionizing radiation, have highly deleterious effects on the dev... |
2,326,735 | Quantifying sulcal and gyral topography in relation to deep seated and ventricular lesions: cadaveric study for basing surgical approaches and review of literature. | Numerical implication of sulcal and gyral topography for surgical approaches has not been studied.</AbstractText>Percentage gain of distance using sulci as compared to that of gyri was calculated by measuring distances toward the ventricles in 15 hemispheres.</AbstractText>Superior frontal sulcus was closest proving gr... |
2,326,736 | Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone. | The acute response of the rodent subventricular zone (SVZ) to traumatic brain injury (TBI) involves a physical expansion through increased cell proliferation. However, the cellular underpinnings of these changes are not well understood. Our analyses have revealed that there are two distinct transit-amplifying cell popu... |
2,326,737 | Fast in vivo quantification of T1 and T2 MRI relaxation times in the myocardium based on inversion recovery SSFP with in vitro validation post Gd-based contrast administration. | A fast clinical imaging technique for quantifying myocardial T1 and T2 relaxation times after Gadolinium (Gd)-based contrast administration within a single breathhold is presented with in vitro validation.</AbstractText>From signal intensity curves in ECG-gated segmented inversion recovery balanced steady state free pr... |
2,326,738 | Inhibitory effects of draxin on axonal outgrowth and migration of precerebellar neurons. | The rhombic lip, a dorsal stripe of the neuroepithelium lining the edge of the fourth ventricle, is the site of origin of precerebellar neurons (PCN), which migrate tangentially towards the floor plate. After reaching the floor plate, they project their axons to the cerebellum. Although previous studies have shown that... |
2,326,739 | MRI surrogates for molecular subgroups of medulloblastoma. | Recently identified molecular subgroups of medulloblastoma have shown potential for improved risk stratification. We hypothesized that distinct MR imaging features can predict these subgroups.</AbstractText>All patients with a diagnosis of medulloblastoma at one institution, with both pretherapy MR imaging and surgical... |
2,326,740 | Identifying early changes in myocardial microstructure in hypertensive heart disease. | The transition from healthy myocardium to hypertensive heart disease is characterized by a series of poorly understood changes in myocardial tissue microstructure. Incremental alterations in the orientation and integrity of myocardial fibers can be assessed using advanced ultrasonic image analysis. We used a modified a... |
2,326,741 | Mature cystic teratoma of skull base and attached to the wall of third ventricle. | An 18-year-old man was admitted with a 1-month history of headache and disturbed visual acuity. Neurological examination revealed a visual field defect of bilateral inferotemporal areas. The endocrinological examination was normal. Magnetic resonance imaging (MRI) revealed a large cystic lesion in the anterior and midd... |
2,326,742 | Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase. | Intracerebral hemorrhage (ICH) is a devastating condition. Existing preclinical ICH models focus largely on striatum but neglect other brain areas such as ventricle, cortex, and hippocampus. Clinically, however, hemorrhagic strokes do occur in these other brain regions. In this study, we established mouse hemorrhagic m... |
2,326,743 | Dysregulation of catalase activity in newborn myocytes during hypoxia is mediated by c-Abl tyrosine kinase. | In the adult heart, catalase (CAT) activity increases appropriately with increasing levels of hydrogen peroxide, conferring cardioprotection. This mechanism is absent in the newborn for unknown reasons. In the present study, we examined how the posttranslational modification of CAT contributes to its activation during ... |
2,326,744 | Heart rate variability is severely impaired among type 2 diabetic patients with hypertension. | The aim of our study was to evaluate the relative effect of diabetes and hypertension on heart rate variability.</AbstractText>Four age-matched groups including type 2 diabetic patients with and without hypertension, non-diabetic patients with essential hypertension and healthy control subjects were studied. Autonomic ... |
2,326,745 | Image quality in children with low-radiation chest CT using adaptive statistical iterative reconstruction and model-based iterative reconstruction. | To evaluate noise reduction and image quality improvement in low-radiation dose chest CT images in children using adaptive statistical iterative reconstruction (ASIR) and a full model-based iterative reconstruction (MBIR) algorithm.</AbstractText>Forty-five children (age ranging from 28 days to 6 years, median of 1.8 y... |
2,326,746 | Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. | Insulin in the brain plays an important role in regulating reproductive function, as demonstrated via conditional brain-specific insulin receptor (Insr) deletion (knockout). However, the specific neuronal target cells mediating the central effects of insulin on the reproductive axis remain unidentified. We first invest... |
2,326,747 | Complementary radial tagging for improved myocardial tagging contrast. | To develop and evaluate complementary radial tagging (CRT) for improved myocardial tagging contrast.</AbstractText>We sought to develop and evaluate CRT, which aims to preserve the radial tag contrast throughout the cardiac cycle. Similar to complementary spatial modulation of magnetization, CRT acquires two sets of im... |
2,326,748 | Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans. | Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a leukodystrophy characterized by myelin vacuolization and caused by mutations in MLC1 or GLIALCAM. Patients with recessive mutations in either MLC1 or GLIALCAM show the same clinical phenotype. It has been shown that GLIALCAM is necessary for the corr... |
2,326,749 | The effects of hormonotherapy administered concurrent radiotherapy and trastuzumab on cardiac toxicity in rats. | This experimental study aims to investigate whether radiotherapy (RT) plus trastuzumab (T) followed by subsequent hormonotherapy increase the cumulative toxic effect on cardiac functions in rats.</AbstractText>A total of 70 Wistar-Albino female rats with a mean weight 213 ± 27 g were randomly divided into equal se... |
2,326,750 | Automated delineation of stroke lesions using brain CT images. | Computed tomographic (CT) images are widely used for the identification of abnormal brain tissue following infarct and hemorrhage in stroke. Manual lesion delineation is currently the standard approach, but is both time-consuming and operator-dependent. To address these issues, we present a method that can automaticall... |
2,326,751 | A new look at cerebrospinal fluid circulation. | According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid space to be absorbed into the blood by the arachnoid villi. This review surveys key developments leading to the... |
2,326,752 | Effect of prior exercise training and myocardial infarction-induced heart failure on the neuronal and glial densities and the GFAP-immunoreactivity in the posterodorsal medial amygdala of rats. | Exercise training has neuroprotective effects whereas myocardial infarction (MI) and heart failure (HF) can cause neuronal death and reactive gliosis in the whole amygdala. The posterodorsal medial amygdala (MePD) is involved with cardiovascular reflexes and the central control of sympathetic/parasympathetic responses.... |
2,326,753 | Heart rate variability and the metabolic syndrome: a systematic review of the literature. | A number of cross-sectional studies have examined associations between heart rate variability and metabolic syndrome, but differences in study populations, data collection and analysis methodologies make synthesis difficult. The purpose of this study was to systematically review published primary research examining ass... |
2,326,754 | Heritability of brain volume change and its relation to intelligence. | Human brain volumes change throughout life, are highly heritable, and have been associated with general cognitive functioning. Cross-sectionally, this association between volume and cognition can largely be attributed to the same genes influencing both traits. We address the question whether longitudinal changes in bra... |
2,326,755 | Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia. | Selective estrogen receptor modulators (SERMs) have been reported to enhance synaptic plasticity and improve cognitive performance in adult rats. SERMs have also been shown to induce neuroprotection against cerebral ischemia and other CNS insults. In this study, we sought to determine whether acute regulation of neurog... |
2,326,756 | Viscoelastic properties of normal and infarcted myocardium measured by a multifrequency shear wave method: comparison with pressure-segment length method. | Our aims were (i) to compare in vivo measurements of myocardial elasticity by shear wave dispersion ultrasound vibrometry (SDUV) with those by the conventional pressure-segment length method, and (ii) to quantify changes in myocardial viscoelasticity during systole and diastole after reperfused acute myocardial infarct... |
2,326,757 | Impact of asymptomatic acute cellular rejection on left ventricle myocardial function evaluated by means of two-dimensional speckle tracking echocardiography in heart transplant recipients. | Our objective was to evaluate the impact of asymptomatic acute cellular rejection (ACR) in left ventricular myocardial strain in heart transplant (HT) recipients by means of two-dimensional speckle tracking echocardiography (2DSTE).</AbstractText>From September 1, 2009 to December 15, 2010 a conventional echocardiograp... |
2,326,758 | A novel combined model of intracerebral and intraventricular hemorrhage using autologous blood-injection in rats. | Intracerebral hemorrhage (ICH) is the least treatable form of stroke and is associated with the worst prognosis. In up to 40% of cases, ICH is further complicated by intraventricular hemorrhage (IVH), which predisposes to hydrocephalus, and increases case-mortality to 80%. However, IVH is not present in widely used pre... |
2,326,759 | Ependymosarcoma with eosinophilic granular cells. | Ependymosarcoma is a new entity of malignant gliomas composed of ependymal and sarcomatous components. Were port a rare case of ependymosarcoma with eosinophlic cells which occurred to the right trigon of the lateral ventricle.A 62-year-old man complained of headaches over a 2-month period. A hard, gray mass was found ... |
2,326,760 | Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study. | Although both high-sensitivity cardiac troponin T (Hs-cTnT) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels are higher among patients with cardiac structural abnormalities than among those with apparently normal hearts, there is considerable overlap between the groups. The authors evaluated 1336 pa... |
2,326,761 | Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche. | Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity has been elusive. Here, we prospectively isolate GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP(+)CD133(+)EGFR(+) (activated neural stem cells [aNSCs]) from the adult ventricular-subventricular zone. aNSCs are ra... |
2,326,762 | The quintessence of quiescence. | Neurogenic niches in the adult mammalian brain are composed of heterogeneous populations of neural stem cells. In this issue of Neuron, Codega et al. (2014) isolate quiescent neural stem cells from the adult subventricular zone and demonstrate their stem cell characteristics. |
2,326,763 | Three types of ependymal cells with intracellular calcium oscillation are characterized by distinct cilia beating properties. | Ependymal cells are multiciliated epithelial cells that line the ventricles in the adult brain. Abnormal function or structure of ependymal cilia has been associated with various neurological deficits. For the first time, we report three distinct ependymal cell types, I, II, and III, based on their unique ciliary beati... |
2,326,764 | Non-linear blending of dual-energy CT data improves depiction of late iodine enhancement in chronic myocardial infarction. | To compare non-linear and linear blending of cardiac dual-energy computed tomography (DECT) for optimal visualization of late iodine enhancement (LIE) in patients with chronic myocardial infarction (CMI). LIE-DECT data from 20 patients with known CMI were retrospectively analyzed. Images were reconstructed using non-li... |
2,326,765 | Unravelling the complex MRI pattern in glutaric aciduria type I using statistical models-a cohort study in 180 patients. | Glutaric aciduria type I (GA-I) is a cerebral organic aciduria caused by inherited deficiency of glutaryl-CoA dehydrogenase and is characterized biochemically by an accumulation of putatively neurotoxic dicarboxylic metabolites. The majority of untreated patients develops a complex movement disorder with predominant dy... |
2,326,766 | EphrinB3 blocks EphB3 dependence receptor functions to prevent cell death following traumatic brain injury. | Eph receptor tyrosine kinases and their membrane-bound ligands, ephrins, have a variety of roles in the developing and adult central nervous system that require direct cell-cell interactions; including regulating axon path finding, cell proliferation, migration and synaptic plasticity. Recently, we identified a novel p... |
2,326,767 | Brain remodelling following endothelin-1 induced stroke in conscious rats. | The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as inflammation and scar formation and cellular responses within the subventricular zone (SVZ) following... |
2,326,768 | The ventricular system and choroid plexus as a primary site for renal cell carcinoma metastasis. | Brain metastases (BM) are the most common intracranial tumours amongst adults. Ten to 40 % of patients with cancer will develop BM. In this study, we observed a high affinity of renal cell carcinoma (RCC) to the ventricular system, with close association to the choroid plexus.</AbstractText>This is a retrospective stud... |
2,326,769 | Neurogenic and non-neurogenic functions of endogenous neural stem cells. | Adult neurogenesis is a lifelong process that occurs in two main neurogenic niches of the brain, namely in the subventricular zone (SVZ) of the lateral ventricles and in the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. In the 1960s, studies on adult neurogenesis have been hampered by the lack of... |
2,326,770 | The role of dyadic organization in regulation of sarcoplasmic reticulum Ca(2+) handling during rest in rabbit ventricular myocytes. | The dyadic organization of ventricular myocytes ensures synchronized activation of sarcoplasmic reticulum (SR) Ca(2+) release during systole. However, it remains obscure how the dyadic organization affects SR Ca(2+) handling during diastole. By measuring intraluminal SR Ca(2+) ([Ca(2+)]SR) decline during rest in rabbit... |
2,326,771 | Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly. | The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent genome-wide association study of LOAD found the strongest evidence of association with CLU at rs1532278, in high linkage disequilibrium with rs11136000. B... |
2,326,772 | Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone. | Adult neurogenesis is a multistep process regulated by several extrinsic factors, including neurotrophins. Among them, little is known about the role of nerve growth factor (NGF) in the neurogenic niches of the mouse. Here we analyzed the biology of adult neural stem cells (NSCs) from the subventricular zone (SVZ) of A... |
2,326,773 | FGFR1 mutations in Rosette-forming glioneuronal tumors of the fourth ventricle. | Rosette-forming glioneuronal tumors (RGNTs) are rare glioneuronal tumors of the fourth ventricle region that preferentially affect young adults. Despite their histologic similarity with pilocytic astrocytomas (PAs), RGNTs do not harbor KIAA1549-BRAF fusions or BRAF mutations, which represent the most common genetic alt... |
2,326,774 | Meningitis related ventriculitis--experience from a tertiary care centre in northern India. | To assess clinical profile and short term outcome of patients with meningitis related ventriculitis.</AbstractText>Case records of 47 patients admitted with a diagnosis of ventriculitis (complicating meningitis) over 3 y were analysed retrospectively.</AbstractText>The mean age of patients was 4.96 mo (20 d - 42 mo). T... |
2,326,775 | The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+). | The Ser96Ala (S96A) mutation within the histidine rich Ca(2+) binding protein (HRC) has recently been linked to cardiac arrhythmias in idiopathic dilated cardiomyopathy patients, potentially attributable to an increase in spontaneous Ca(2+) release events. However, the molecular mechanism connecting the S96A mutation o... |
2,326,776 | Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up. | Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular determinants of the toxic damage and associated myocardial remodeling remain to be established. Furthermore, details on the different propensity of the left and right v... |
2,326,777 | Hemorrhagic onset of hemangioblastoma located in the dorsal medulla oblongata presenting with tako-tsubo cardiomyopathy and neurogenic pulmonary edema: a case report. | Here, we present a case of dorsal medulla oblongata hemangioblastoma with fourth ventricular hemorrhage. A 23-year-old female developed sudden consciousness disturbance, and CT revealed hemorrhage in all cerebral ventricles and a hyperdense mass in the cisterna magna. Although the reddish tumor located in the dorsal me... |
2,326,778 | Nanoparticle oxygen delivery to the ischemic heart. | Currently there are no medications that can be administered to help deliver more oxygen to the myocardial region experiencing abnormal perfusion. The purpose of this study was to look at the nanoparticle dodecafluoropentane in an emulsion as an oxygen carrier. Using nanoparticles as an oxygen carrier is advantageous be... |
2,326,779 | Automated Identification of Infarcted Myocardium Tissue Characterization Using Ultrasound Images: A Review. | Myocardial infarction (MI) or acute myocardial infarction commonly known as heart attack is one of the major causes of cardiac death worldwide. It occurs when the blood supply to the portion of the heart muscle is blocked or stopped causing death of heart muscle cells. Early detection of MI will help to prevent the inf... |
2,326,780 | New insights into septo-optic dysplasia. | Septo-Optic Dysplasia (SOD) is a rare disorder with postulated genetic and environmental etiology. Whilst initially considered as a very rare disease (defined as incidence of approx. 1 in 50,000 births) recent data gave a reported incidence of 1 in 10,000, with equal sex distribution. The diagnosis of SOD is predominan... |
2,326,781 | Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone. | Lymphocytic choriomeningitis virus (LCMV) can be transmitted through congenital infection, leading to persistent infection of numerous organ systems including the central nervous system (CNS). Adult mice persistently infected with LCMV (LCMV-cgPi mice) exhibit learning deficits, such as poor performance in spatial disc... |
2,326,782 | ATF3 is a novel nuclear marker for migrating ependymal stem cells in the rat spinal cord. | The present study identified ATF3 as a novel dynamic marker for ependymal stem/progenitor cells (nestin, vimentin and SOX2 positive) around the central canal of the neonatal or adult rat spinal cord. While quiescent ependymal cells showed cytoplasmic ATF3 expression, during 6-24h in vitro these cells mobilized and acqu... |
2,326,783 | Quasi-static image-based immersed boundary-finite element model of left ventricle under diastolic loading. | Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a st... |
2,326,784 | Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.<Pagination><StartPage>e96691</StartPage><MedlinePgn>e96691</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">e96691</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0096691</ELocation... | Cardiomyocytes from diseased hearts are subjected to complex remodeling processes involving changes in cell structure, excitation contraction coupling and membrane ion currents. Those changes are likely to be responsible for the increased arrhythmogenic risk and the contractile alterations leading to systolic and diast... |
2,326,785 | Recurrence of nonfamilial cardiac myxoma in the left ventricle: a case report. | A left atrial myxoma was found and removed in a 47-year-old woman admitted for acute ischemic cerebrovascular disease, without family history of cardiac tumor. Follow-up echocardiography, 15 months later, demonstrated a new myxoma in the left ventricle. |
2,326,786 | A single pathophysiological pathway in Takotsubo cardiomyopathy: Catecholaminergic stress.<Pagination><StartPage>245</StartPage><EndPage>252</EndPage><MedlinePgn>245-52</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.acvd.2014.04.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1875-21... | Introduction of newly discovered cardiovascular therapeutics into first-in-man trials depends on a strictly regulated ethical and legal roadmap. One important prerequisite is a good understanding of all safety and efficacy aspects obtained in a large animal model that validly reflect the human scenario of myocardial in... |
2,326,787 | Free-breathing 3D late gadolinium enhancement imaging of the left ventricle using a stack of spirals at 3T. | To develop navigator-gated free-breathing 3D spiral late gadolinium enhancement (LGE) imaging of the left ventricle at 3T and compare it with conventional breath-hold 2D Cartesian imaging.</AbstractText>Equivalent slices from 3D spiral and multislice 2D Cartesian acquisitions were compared in 15 subjects in terms of im... |
2,326,788 | Localization of Kv4.2 and KChIP2 in lipid rafts and modulation of outward K+ currents by membrane cholesterol content in rat left ventricular myocytes. | Lipid rafts are cholesterol-enriched microdomains of the cell membrane. Here we investigate the localization of the pore forming K(+)-channel α-subunit Kv4.2 and the β-subunit KChIP2, underlying the transient outward K(+) current (I to), in lipid rafts in left ventricular myocytes. Furthermore, we explored ... |
2,326,789 | [Liponeurocytoma in the left lateral ventricle. Presentation of the first case reported in Spain and literature review]. | Supratentorial liponeurocytoma is a rare tumor, predominantly appearing in young males. It most commonly affects the lateral ventricles, with involvement of the third ventricle being exceptional. It is defined as a low-grade neuroglial tumor, with areas of associated lipomatosis. The most common clinical manifestation ... |
2,326,790 | [Proliferation of adult mammalian ventricular cardiomyocytes: a sporadic but feasible phenomenon]. | Proliferation of adult mammalian ventricular cardiomyocytes has been ruled out by some researchers, who have argued that these cells are terminally differentiated; however, this dogma has been rejected because other researchers have reported that these cells can present the processes necessary to proliferate, that is, ... |
2,326,791 | The role of dye affinity in optical measurements of Cai(2+) transients in cardiac muscle. | Previous experiments in cultures of neonatal rat myocytes demonstrated that the shape of Cai(2+) transients measured using high-affinity Ca(2+)-sensitive dyes may be misrepresented. The purpose of this study was to examine the role of dye affinity in Cai(2+) measurements in intact adult cardiac tissue by comparing opti... |
2,326,792 | Mucin gene expression in reflux laryngeal mucosa: histological and in situ hybridization observations. | Objectives/Hypothesis. To determine if laryngopharyngeal reflux alters mucin gene expression in laryngeal mucosa. Methods. In situ hybridization was employed to study the expression of the 8 well-characterised mucin genes MUC1-4, 5AC, 5B, 6, and 7 in reflux laryngeal mucosa from laryngeal ventricles, posterior commissu... |
2,326,793 | Human amniotic fluid stem cells: neural differentiation in vitro and in vivo. | The successful integration of stem cells after their implantation into the brain has become a central issue in modern neuroscience. In this study, we test the neural differentiation potential of c-Kit(+)/Oct-4(+) human amniotic fluid stem cells (hAFSCs) in vitro and their survival and integration in vivo. hAFSCs were i... |
2,326,794 | MicroRNA-26a involved in Toll-like receptor 9‑mediated lung cancer growth and migration. | Toll-like receptor 9 (TLR9) has been shown to have a significant role in cancer. MicroRNAs (miRNAs), a group of small non-coding RNAs that fine tune translation of multiple target mRNAs, are involved in the development and progression of human cancers. The present study was undertaken to determine the roles of TLR9 on ... |
2,326,795 | Alterations in cardiomyocyte function after pulmonary treatment with stainless steel welding fume in rats. | Welding fume is composed of a complex of different metal particulates. Pulmonary exposure to different welding fumes may exert a negative impact on cardiac function, although the underlying mechanisms remain unclear. To explore the effect of welding fumes on cardiac function, Sprague-Dawley rats were exposed by intratr... |
2,326,796 | Regional distribution and accumulation of lead in caprine brain tissues following a long-term oral dosing regimen. | It is well known that the brain is a key target organ for lead (Pb)-induced toxicity, with exposure potentially resulting in numerous adverse neurological effects. However, information on the distribution and accumulation of Pb within different brain regions is scarce. In this study, Pb uptake and accumulation were cha... |
2,326,797 | Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation. | An exaggerated or persistent inflammatory activation after myocardial infarction (MI) leads to maladaptive healing and subsequent remodeling of the left ventricle. Foxp3(+) CD4(+) regulatory T cells (Treg cells) contribute to inflammation resolution. Therefore, Treg cells might influence cardiac healing post-MI.</Abstr... |
2,326,798 | The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system. | Mental and neurological illnesses affect one in four people. While genetic linkage analyses have shown an association of nuclear distribution factor E (NDE1, or NudE) and its ohnolog NDE-like 1 (NDEL1, or Nudel) with mental disorders, the cellular mechanisms remain unclear. In the present study, we have demonstrated th... |
2,326,799 | A new protocol to treat moderate to severe intraventricular hemorrhage with obstructive hydrocephalus. | For patients with intraventricular hemorrhage (IVH) accompanied by obstructive hydrocephalus, external ventricular drainage (EVD) alone is proven to be often insufficient, and lumbar drainage (LD) is proven promising but considered contraindicative in the acute phase. The objective was to analyze the safety and feasibi... |
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