Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,329,800 | Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors. | The glucagon-like peptide 1 (GLP-1) is a hormone which is produced in the enteroendocrine L-cells in the ileum and the neurons of nucleus tractus solitarius (NTS) in the brain which has numerous metabolic effects. The central GLP-1R's role in cognitive functioning is well known. On the contrary, it has been shown that ... |
2,329,801 | Automated Segmentation of Lateral Ventricles in Alzheimer's Conditions Using UNET++ Model. | Accurate diagnosis of Alzheimer's disease (AD) in early stage can control the disease progression. Enlargement of Lateral Ventricles (LV) is one of the significant imaging biomarkers for the differentiation of Alzheimer's conditions. However, segmentation of accurate LV for analysis is still challenging. In this work, ... |
2,329,802 | Brain Abnormalities in Patients with Germline Variants in <i>H3F3</i>: Novel Imaging Findings and Neurologic Symptoms Beyond Somatic Variants and Brain Tumors. | Pathogenic somatic variants affecting the genes Histone 3 Family 3A and 3B</i> (H3F3</i>) are extensively linked to the process of oncogenesis, in particular related to central nervous system tumors in children. Recently, H3F3</i> germline missense variants were described as the cause of a novel pediatric neurodevelopm... |
2,329,803 | Locoregional delivery of CAR-T cells in the clinic. | Cellular therapies utilizing T cells expressing chimeric antigen receptors (CARs) have garnered significant interest due to their clinical success in hematological malignancies. Unfortunately, this success has not been replicated in solid tumors, with only a small fraction of patients achieving complete responses. A nu... |
2,329,804 | Isolated Right Ventricular Air Embolism. | Vascular air embolism (VAE) is an uncommon but potentially life-threatening event often associated with various procedures and diagnostic tests. Understanding this challenging incident will enable physicians to evaluate, diagnose and manage this incident successfully. We present a case of a 73-year-old male who develop... |
2,329,805 | Diffusion-weighted imaging in the early diagnosis of intraventricular rupture of a brain abscess. | Brain abscess is a potentially fatal injury that must be treated promptly to avoid complications that require neurosurgery such as intraventricular rupture. Patients with brain abscess may exhibit a multiple variety of nonspecific symptoms, simulating the presence of neurological diseases such as ischemic stroke or int... |
2,329,806 | Posterior fossa syndrome in a population of children and young adults with medulloblastoma: a retrospective, multicenter Italian study on incidence and pathophysiology in a histologically homogeneous and consecutive series of 136 patients. | Posterior fossa syndrome (PFS) is a set of debilitating complications that can occur after surgery for posterior fossa tumors. This study aimed to assess the preoperative radiological and surgical risk factors for the onset of PFS in a histologically homogeneous population of children with medulloblastoma and compare i... |
2,329,807 | Patent Ductus Arteriosus Stent Versus Surgical Aortopulmonary Shunt for Initial Palliation of Cyanotic Congenital Heart Disease with Ductal-Dependent Pulmonary Blood Flow: A Systematic Review and Meta-Analysis.<Pagination><StartPage>e024721</StartPage><MedlinePgn>e024721</MedlinePgn></Pagination><ELocationID EIdType="p... | Background In patients with ductal-dependent pulmonary blood flow, initial palliation includes catheter-based patent ductus arteriosus (PDA) stent or surgical aortopulmonary shunt (APS). This meta-analysis aimed to compare outcomes between PDA stent and APS. Methods and Results A comprehensive literature search yielded... |
2,329,808 | Repositioning a Displaced Right Ventricular Pacing Lead via Percutaneous Approach in Three Patients. | Lead-related complications compose a noticeable share of device-related complications. Pacemaker lead perforation is a recognized complication of lead implantation, particularly with active fixation leads, and should be considered in postoperative lead malfunction cases. We herewith present 3 challenging cases with ven... |
2,329,809 | Ultrasound-Based Estimation of Fibre-Directional Strain: A Simulation Study. | Left ventricular (LV) strains are typically represented with respect to the imaging axes. Contraction within the myocardium occurs along myofibres, which vary in orientation. Therefore, a mismatch exists between the direction in which strain is calculated and that in which contraction occurs. In this study, ultrasound-... |
2,329,810 | OLIG2 immunolabeling in feline ependymoma. | Ependymoma, one of the most common gliomas in cats, occurs most often in the lateral and third ventricles and has variable histologic patterns that often form rosettes and pseudorosettes. Oligodendrocyte transcription factor (OLIG2) is expressed in oligodendrocyte precursor cells and mature oligodendrocytes. Although w... |
2,329,811 | Ketamine administration ameliorates anesthesia and surgery-induced cognitive dysfunction via activation of TRPV4 channel opening. | Perioperative neurocognitive disorder (PND) is a common complication associated with anesthesia and surgery in the elderly. The dysfunction of transient receptor potential vanilloid 4 (TRPV4) has been associated with a number of diseases, including Alzheimer's disease. Given that ketamine can reportedly improve PNDs, t... |
2,329,812 | Cholesterol granuloma in the choroid plexus of a cat. | This case report describes the clinical presentation, magnetic resonance imaging (MRI) as well as the histopathological findings in an elderly cat with an intracranial cholesterol granuloma.</AbstractText>An 11.5-year-old, male neutered cat was presented at the emergency service with deteriorating behavioral changes in... |
2,329,813 | Bedside Ultrasound for Ventricular Size Monitoring in Patients with PEEK Cranioplasty: A Preliminary Experience of Technical Feasibility in Neurotrauma Setting. | Posttraumatic hydrocephalus is a known complication after traumatic brain injury, particularly affecting patients undergoing decompressive craniectomy. Posttraumatic hydrocephalus monitoring in these patients represents a common issue in neurosurgical practice. Patients require periodical assessments by means of comput... |
2,329,814 | A diffusion tensor imaging analysis of white matter microstructures in non-operated craniosynostosis patients. | In 7 to 15-year-old operated syndromic craniosynostosis patients, we have shown the presence of microstructural anomalies in brain white matter by using DTI. To learn more about the cause of these anomalies, the aim of the study is to determine diffusivity values in white matter tracts in non-operated syndromic cranios... |
2,329,815 | Effects of intracerebroventricular injection of corticotrophin releasing factor on the gene expression of ghrelin and corticotrophin releasing factor receptors in broiler chickens. | This study aimed to investigate the effects of corticotropin-releasing factor (CRF) on the feed intake of broiler chickens and explore its influencing mechanism.</AbstractText>The study included two trials. In trial 1, 32 male broiler chickens (Arbor Acres, Gallus gallus domesticus) were given ventricle buried tubes, a... |
2,329,816 | Rare Case of Pediatric Disseminated Choroid Plexus Papilloma: Literature Review and Call for Reclassification. | Choroid plexus tumors are rare neuroectodermal tumors that arise from the choroid plexus. Choroid plexus papillomas (CPPs) represent the lowest grade of these types of tumors and have a WHO grade I designation. Despite their typical low grade, some CPPs can exhibit aggressive behaviors including parenchymal invasion an... |
2,329,817 | Effects of four weeks lasting aerobic physical activity on cardiovascular biomarkers, oxidative stress and histomorphometric changes of heart and aorta in rats with experimentally induced hyperhomocysteinemia. | The aim of this study was to examine the effects of hyperhomocysteinemia and aerobic physical activity on changes of cardiovascular biomarkers in sera, oxidative stress in cardiac tissue, and histomorphometric parameters of heart and aorta in rats. Experiments were conducted on male Wistar albino rats organized into fo... |
2,329,818 | [Giant petrosal meningioma invading the fourth ventricle: total removal of a recurrent tumor after eighteen years. Neurosurgical nuances. Case report and literature review]. | The authors present a patient and neurosurgical nuances of total resection of recurrent meningioma of posterior surface of petrous bone 65´35´30 mm. The tumor captured two critical zones of posterior cranial fossa with unusual frontal growth and spread from the surface of petrous bone to the fourth ventricle.... |
2,329,819 | Silibinin Ameliorates Formaldehyde-Induced Cognitive Impairment by Inhibiting Oxidative Stress. | Silibinin is a flavonoid extracted from the medicinal plant Silybum marianum (milk thistle), traditionally used to treat liver disease. Recent studies have shown that the antioxidative stress and anti-inflammatory effects of milk thistle are used in the treatment of neurological diseases. Silibinin has antioxidative st... |
2,329,820 | Atypical Choroid Plexus Papilloma of the Fourth Ventricle in an Adult: A Case Report. | Atypical choroid plexus papilloma (aCPP) is very rarely seen in adults. Here, we present the case of a 47-year-old male with several months of headache, nausea, dizziness, and imbalance who was found to have an enhancing mass of the fourth ventricle with imaging findings suggestive of likely ependymoma. The patient und... |
2,329,821 | Migrating Foreign Body in the Heart. | Foreign bodies in the heart are a rare condition and an exact mechanism for this occurrence has not been well described. These objects can reach the heart by direct penetration due to local trauma or through intravenous migration or may remain in the heart after medical procedures. The most common foreign bodies that r... |
2,329,822 | Dandy-Walker Malformation With Hydrocephalus: Diagnosis and Its Treatment. | Dandy-Walker malformation is an uncommon type of brain malformation that occurs during embryonic development of the cerebellum and fourth ventricle. A case of Dandy-Walker malformation with hydrocephalus is being elaborated. The patient was operated on by the neurosurgery department and underwent ventriculoperitoneal s... |
2,329,823 | The Effects of Vagus Nerve Stimulation on Ventricular Electrophysiology and Nitric Oxide Release in the Rabbit Heart. | <b>Background:</b> Abnormal autonomic activity including impaired parasympathetic control is a known hallmark of heart failure (HF). Vagus nerve stimulation (VNS) has been shown to reduce the susceptibility of the heart to ventricular fibrillation, however the precise underlying mechanisms are not well understood and t... |
2,329,824 | In ovo exposure to cadmium causes right ventricle hyperplasia due to cell proliferation of cardiomyocytes. | Cadmium (Cd) is an environmental and occupational pollutant inhaled through smoking or ingested through contaminated food. Yet, little is known about its teratogenicity. In this study, the effects of Cd on embryonic heart development were investigated by exposing Cd to chicken embryos in ovo. Fertilized eggs were treat... |
2,329,825 | Modified Haller index validation and correlation with left ventricular strain in a cohort of subjects with obesity and without overt heart disease.<Pagination><StartPage>1907</StartPage><EndPage>1919</EndPage><MedlinePgn>1907-1919</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11739-022-03026-... | The present study was primarily designed to validate the modified Haller index (MHI), the ratio of chest transverse diameter over the distance between sternum and spine, measured by a ruler and transthoracic echocardiography (TTE), respectively, in a cohort of subjects with obesity, but otherwise healthy, by comparing ... |
2,329,826 | Tectal Plate Gliomas Masquerading as Idiopathic Aqueduct Stenosis. | Aqueduct stenosis is a recognized cause of obstructive hydrocephalus in children and can be treated effectively with endoscopic third ventriculostomy. Preoperative magnetic resonance imaging is often diagnostic of the cause of aqueduct stenosis. We describe 2 pediatric cases with obstructive hydrocephalus secondary to ... |
2,329,827 | Prediction of 6 months endoscopic third ventriculostomy success rate in patients with hydrocephalus using a multi-layer perceptron network. | Discrimination between patients most likely to benefit from endoscopic third ventriculostomy (ETV) and those at higher risk of failure is challenging. Compared to other standard models, we have tried to develop a prognostic multi-layer perceptron model based on potentially high-impact new variables for predicting the E... |
2,329,828 | Regional left ventricular endocardial strains estimated from low-dose 4DCT: Comparison with cardiac magnetic resonance feature tracking.<Pagination><StartPage>5841</StartPage><EndPage>5854</EndPage><MedlinePgn>5841-5854</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mp.15818</ELocationID><Abstr... | Contemporary multicenter data regarding midterm outcomes for neonates with pulmonary atresia with intact ventricular septum are lacking. We sought to describe outcomes in a contemporary multicenter cohort, determine factors associated with end-states, and evaluate the effect of right ventricular coronary dependency and... |
2,329,829 | Significance of aortoseptal angle anomalies to left ventricular hemodynamics and subaortic stenosis: A numerical study. | Discrete subaortic stenosis (DSS) is an obstructive cardiac disease caused by a membranous lesion in the left ventricular (LV) outflow tract (LVOT). Although its etiology is unknown, the higher prevalence of DSS in LVOT anatomies featuring a steep aortoseptal angle (AoSA) suggests a potential role for hemodynamics. The... |
2,329,830 | "Ependymal-in" Gradient of Thalamic Damage in Progressive Multiple Sclerosis. | Leptomeningeal and perivenular infiltrates are important contributors to cortical grey matter damage and disease progression in multiple sclerosis (MS). Whereas perivenular inflammation induces vasculocentric lesions, leptomeningeal involvement follows a subpial "surface-in" gradient. To determine whether similar gradi... |
2,329,831 | Surgical Management after Chiari Decompression Failure: Craniovertebral Junction Revision versus Shunting Strategies. | Revision surgery after posterior fossa decompression for Chiari malformation is not uncommon and poses both strategic and technical challenges. We conducted a single-center retrospective cohort study including all adult patients who underwent revision surgery after posterior fossa decompression for Chiari type I malfor... |
2,329,832 | The Periventricular Nucleus as a Brain Center Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis. | Since the 1980s, the concept of dopamine-rich brain centers as clusters of only dopaminergic neurons has been fundamentally revised. It has been shown that, in addition to dopaminergic neurons, most of these centers contain neurons expressing one of the enzymes of dopamine synthesis: tyrosine hydroxylase (TH) or aromat... |
2,329,833 | Role of Diffusion Tensor Imaging in Diagnosis and Estimation of Shunt Effect for Hydrocephalus in Stroke Patients: A Narrative Review. | Hydrocephalus is a dilatation of the brain ventricular system by the accumulation of cerebrospinal fluid within the ventricle caused by impaired cerebrospinal fluid circulation or clearance. A diagnosis of hydrocephalus at the chronic stage of stroke has been mainly made by clinical features and radiologic findings on ... |
2,329,834 | Histological reinterpretation of paraphysis cerebri in Ambystoma mexicanum. | Intraventricular and extraventricular choroid plexuses are neuroepithelial folds which arise from the roof of the diencephalon. We describe the circumventricular structure of the diencephalon roof (paraphysis cerebri) during the various development stages of Ambystoma mexicanum. The parasagittal sections of the larvae ... |
2,329,835 | Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs. | Alterations of RNA editing that affect the secondary structure of RNAs can cause human diseases. We therefore studied RNA editing in failing human hearts. Transcriptome sequencing showed that adenosine-to-inosine (A-to-I) RNA editing was responsible for 80% of the editing events in the myocardium. Failing human hearts ... |
2,329,836 | An ultrastructural study of the deep pineal gland of the Sprague Dawley rat using transmission and serial block face scanning electron microscopy: cell types, barriers, and innervation. | The morphology of the deep pineal gland of the Sprague Dawley rat was investigated by serial block face scanning electron microscopy. Cells were three-dimensionally (3-D) reconstructed using the software Fiji TrackEM. The deep pineal gland consisted of 2-5 layers of electron-lucent pinealocytes, with a euchromatic nucl... |
2,329,837 | Pregnancy in Pulmonary Arterial Hypertension: A Multidisciplinary Approach. | Pulmonary arterial hypertension (PAH), a female predominant disease, carries a high maternal and fetal mortality in pregnancy despite improved insight and the development of novel therapies. The high risk is attributed to the adaptive changes that take place to promote healthy fetal development during pregnancy, which ... |
2,329,838 | Exercising with a Single Ventricle: Limitations and Therapies. | Treatment for Hypoplastic Left Heart Syndrome (HLHS) and other single ventricle conditions requires a series of surgical interventions for long-term survival, typically culminating in the Fontan procedure. The result is an abnormal circulatory physiology with an absence of a sub-pulmonary ventricle. Exercise capacity i... |
2,329,839 | Concurrent intraventricular intracranial myxoid mesenchymal tumor and ependymoma in a long-term Ewing sarcoma survivor. | Intracranial myxoid mesenchymal tumor, FET::CREB fusion positive is a rare, recently described central nervous system neoplasm. It is characterized by EWSR1::CREB family transcription factor fusion, typically arises in children and adolescents, and is locally aggressive even after gross total resection. Currently, ther... |
2,329,840 | Leptomeningeal disease and tumor dissemination in a murine diffuse intrinsic pontine glioma model: implications for the study of the tumor-cerebrospinal fluid-ependymal microenvironment. | Leptomeningeal disease and hydrocephalus are present in up to 30% of patients with diffuse intrinsic pontine glioma (DIPG), however there are no animal models of cerebrospinal fluid (CSF) dissemination. As the tumor-CSF-ependymal microenvironment may play an important role in tumor pathogenesis, we identified character... |
2,329,841 | Fourth Ventricle Tumors: A Review of Series Treated With Microsurgical Technique. | Tumors of the IV ventricle represent 1-5% of all intracranial lesions; they are implicated in 2/3 of the tumors of the ventricular system. According to modern standards, the first treatment stage for this pathology is microsurgical removal. Currently, for the removal of neoplasms of the IV ventricle and brainstem, the ... |
2,329,842 | Patient tilt improves efficacy of CO<sub>2</sub> field-flooding in minimally invasive cardiac surgery. | Space limitations during minimally invasive cardiac surgery impede consistent use of CO2</sub> field-flooding. We compared different gas delivery methods, flow rates and the effect of patient inclination.</AbstractText>A gastight model of MICS surgery with internal organs and right thoracotomy wound was created from a ... |
2,329,843 | Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson's disease mice. | Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, and its incidence is predicted to increase worldwide. Striatal dopamine depletion caused by substantia nigra (SN) degeneration is a pathological hallmark of PD and is strongly associated with cardinal motor and non-m... |
2,329,844 | Intraventricular Bone Dust Migration after Endoscopic Third Ventriculostomy: Illustrative Report of 2 Cases. | Autologous bone dust replacement is a commonly used technique to seal a defect created from a burr hole. However, postoperative migration of these bone fragments may occur as an uncommon complication of endoscopic third ventriculostomy (ETV).</AbstractText>We report 2 cases of intraventricular bone dust migration resul... |
2,329,845 | Investigation of white blood cell characteristics in cerebrospinal fluid samples at pediatric brain tumor diagnosis. | The role of white blood cells (WBC) in the pediatric central nervous system (CNS) tumor microenvironment is incompletely defined. We hypothesized that the WBC profile in cerebrospinal fluid (CSF) correlates with the presence of tumor cells and prognosis in pediatric CNS tumors, as well as other patient and disease char... |
2,329,846 | Identifying common and distinct subcortical volumetric abnormalities in 3 major psychiatric disorders: a single-site analysis of 640 participants. | Subcortical volumetric abnormalities in schizophrenia, bipolar disorder and major depressive disorder (MDD) have been consistently found on a single-diagnosis basis in previous studies. However, whether such volumetric abnormalities are specific to a particular disorder or shared by other disorders remains unclear.</Ab... |
2,329,847 | Primary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level of Consciousness: A Case Report and Literature Review on Challenges in Diagnosis and Management. | BACKGROUND Burkitt lymphoma (BL) is an aggressive subtype of B-cell non-Hodgkin lymphoma (NHL) rarely affecting the central nervous system (CNS) as a primary disease. Over the past years, only a few cases of primary CNS Burkitt lymphoma were reported. There is a challenge in early recognition and diagnosis of this type... |
2,329,848 | Comparison of two-dimensional and three-dimensional U-Net architectures for segmentation of adipose tissue in cardiac magnetic resonance images. | The process of identifying cardiac adipose tissue (CAT) from volumetric magnetic resonance imaging of the heart is tedious, time-consuming, and often dependent on observer interpretation. Many 2-dimensional (2D) convolutional neural networks (CNNs) have been implemented to automate the cardiac segmentation process, but... |
2,329,849 | Baz1b Dosage Influences Cardiovascular Function, Predisposing to Dilated Cardiomyopathy.<ELocationID EIdType="doi" ValidYN="Y">10.1096/fasebj.2022.36.S1.R2293</ELocationID><Abstract><AbstractText>BAZ1B is one of several genes deleted in Williams-Beuren Syndrome (WBS), a complex, multisystem genetic condition that occur... | BAZ1B is one of several genes deleted in Williams-Beuren Syndrome (WBS), a complex, multisystem genetic condition that occurs in ~1 in 8000 live births. Also known as Williams Syndrome Transcription Factor (WSTF), BAZ1B is thought to be essential for neural crest migration. To evaluate the impact of Baz1b loss of funct... |
2,329,850 | Magnetic Resonance Imaging of Unusual Neoplasms Related to Foramen of Luschka: A Review for Differential Diagnosis. | There are many types of neoplasms in or around the foramen of Luschka (FL), and definitive diagnosis in some cases requires knowledge of imaging findings. The uncommon and challenging neoplasms with FL involvement considered in this study are exophytic brainstem glioma, primary glioblastoma of the cerebellopontine angl... |
2,329,851 | Performance of a Risk Analytic Tool (Index of Tissue Oxygen Delivery "IDO2") in Pediatric Cardiac Intensive Care Unit of a Developing Country. | To determine the performance of a commercially available risk analytic tool (IDO2) to estimate the risk for SVO2 < 40% in patients admitted in cardiac intensive care unit (CICU).</AbstractText>Medical and T3 records of all patients (aged 1 day to 12 years, weight >2 kg) who received care in the CICU between Octob... |
2,329,852 | Hypertrophic Olivary Degeneration Postoperatively Following Pilocytic Astrocytoma Resection. | A 25-year-old male presented with headaches 3 weeks after a car accident. His magnetic resonance imaging images showed a hemorrhagic vermis mass with fourth ventricle effacement. One month later, he underwent suboccipital craniotomy for removal of a pilocytic astrocytoma. A 3-month postoperative scan demonstrated ... |
2,329,853 | Racemose Fourth Ventricle Neurocysticercosis Excision Through Telovelar Approach and Hydrodissection. | Intraventricular neurocysticercosis is associated with more severe complications and a worse overall outcome.<sup>1</sup><sup>,</sup><sup>2</sup> Fourth ventricle neurocysticercosis (FVNCC) often presents with cerebrospinal fluid obstruction and hydrocephalus by means of direct mechanical occlusion of ventricular outle... |
2,329,854 | Left atrioventricular coupling index in hypertrophic cardiomyopathy and risk of new-onset atrial fibrillation.<Pagination><StartPage>87</StartPage><EndPage>93</EndPage><MedlinePgn>87-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijcard.2022.06.017</ELocationID><ELocationID EIdType="pii" V... | This study aimed to investigate the association between left atrioventricular coupling index (LACI) and the occurrence of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).</AbstractText>A total of 373 patients with HCM and no history of AF were evaluated by transthoracic echocardiography. LAC... |
2,329,855 | Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus. | The choroid plexus is a tissue located in the lateral ventricles of the brain and is composed mainly of choroid plexus epithelium cells. The main function is currently thought to be the secretion of cerebrospinal fluid and the regulation of its pH, and more functions are gradually being demonstrated. Assistance in the ... |
2,329,856 | Value of ultrasound fusion imaging in detecting vascular cerebral white matter pathology. | Transcranial sonography is beside magnetic resonance imaging (MRI) and computed tomography, a well-established imaging method for evaluation of brain parenchyma and already implicated in various neurological disorders as bed-side investigation possibility in clinical routine. The aim of this study was the qualitative a... |
2,329,857 | Diffuse midline glioma with H3-K27M mutation: A rare case with GFAP-positive anucleate whorled patterns. | Diffuse midline glioma with H3-K27M mutation is an infiltrative high-grade glioma, with predominantly astrocytic differentiation.</AbstractText>A 54-year-old Chinese woman presented with memory loss for a month and walking instability for 15 days.</AbstractText>Magnetic resonance imaging showed a mass shadow of isometr... |
2,329,858 | Postoperative cerebro spinal fluid diversion in patients with third ventricular colloid cysts. | Colloid cysts are a group of CNS neoplasms that usually present with features of CSF flow obstruction. The treatment is by microsurgical, endoscopic or stereotactic techniques. Hydrocephalus usually resolves postoperatively, but in around 3-7% of cases symptoms persist and ultimately require CSF diversion. Several fact... |
2,329,859 | Misbehaving Guests in the Right Ventricle: Macrophage-NLRP3 Activation in Pulmonary Hypertension.<Pagination><StartPage>532</StartPage><EndPage>534</EndPage><MedlinePgn>532-534</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1164/rccm.202205-0977ED</ELocationID><AuthorList CompleteYN="Y"><Author Vali... | Sepsis is an increasingly worldwide problem; it is currently regarded as a complex life-threatening dysfunction of one or more organs as a result of dysregulated host immune response to infections. The heart is one of the most affected organs, as roughly 10% to 70% of sepsis cases are estimated to turn into sepsis-indu... |
2,329,860 | Bridging neuroradiology and neuroanatomy: NOW<i>in</i>BRAIN-a repository with sequences of correlated and labeled planar-surface neuroimages. | <b>Purpose</b>: Integrating neuroradiology with neuroanatomy is essential in medical neuroeducation and neuroimage interpretation. To bridge 2D neuroradiology and 3D neuroanatomy, spatially correlated pairs of labeled images were employed, planar radiologic, and planar-surface combined. <b>Research design</b>: The meth... |
2,329,861 | Brain Structure Among Middle-aged and Older Adults With Long-standing Type 1 Diabetes in the DCCT/EDIC Study. | Individuals with type 1 diabetes mellitus (T1DM) are living to ages when neuropathological changes are increasingly evident. We hypothesized that middle-aged and older adults with long-standing T1DM will show abnormal brain structure in comparison with control subjects without diabetes.</AbstractText>MRI was used to co... |
2,329,862 | Natural history of MRI brain volumes in patients with neuronal ceroid lipofuscinosis 3: a sensitive imaging biomarker. | Grey matter (GM) atrophy due to neuronal loss is a striking feature of patients with CLN3 disease. A precise and quantitative description of disease progression is needed in order to establish an evaluation tool for current and future experimental treatments. In order to develop a quantitative marker to measure brain v... |
2,329,863 | Choroid Plexus Papilloma of the Fourth Ventricle in a Pediatric Patient: A Case Report. | Choroid plexus papilloma (CPP) is a rare intraventricular tumor. The common locations of the tumor vary based on the age of the patient. It usually occurs in the supratentorial region in children, however in adult patients, these tumors commonly present in the infratentorial region. We are presenting a rare c... |
2,329,864 | Disseminated <i>Cunninghamella bertholletiae</i> mucormycosis with protracted clinical course and formation of a large intra-ventricular mural thrombus. | We report the autopsy findings of a case of disseminated mucormycosis caused by <i>Cunninghamella bertholletiae</i>, a rare pathogenic fungus of the family <i>Mucoraceae</i>. The patient was a 49-year-old woman with B-lymphoblastic leukemia with hyperdiploidy, who died of progressive heart failure 4 months after induct... |
2,329,865 | Magendie's foramen debridement and catheterisation for the treatment of syringomyelia due to diffuse craniocervical junction arachnoiditis. A case report and technical note. | A 36 year old woman was referred to our department for symptomatic lumbar spinal arachnoiditis following an epidural anaesthesia for childbirth. She did not had other known causative factor and she was free of any neurological symptoms before. She rapidly developed lower limbs impairment by compressing intradural ... |
2,329,866 | Introduction of high-fat and very-high-fat diets associated with fructose drink in critical development periods causes cardiovascular damage in rats at the beginning of adult life. | Exposure to an obesogenic environment at critical stages of human development may lead to cardiovascular damage during early adulthood, such as left ventricular hypertrophy (LVH). The objective of this study is to investigate whether the consumption of diets with different levels of fat associated with fructose drink, ... |
2,329,867 | Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation.<Pagination><StartPage>e1010141</StartPage><MedlinePgn>e1010141</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">e1010141</ELocationID><ELocationI... | The SILICOFCM project mainly aims to develop a computational platform for in silico clinical trials of familial cardiomyopathies (FCMs). The unique characteristic of the platform is the integration of patient-specific biological, genetic, and clinical imaging data. The platform allows the testing and optimization of me... |
2,329,868 | miRNA-200b-A Potential Biomarker Identified in a Porcine Model of Cardiogenic Shock and Mechanical Unloading. | Cardiogenic shock (CS) alters whole body metabolism and circulating biomarkers serve as prognostic markers in CS patients. Percutaneous ventricular assist devices (pVADs) unload the left ventricle by actively ejecting blood into the aorta. The goal of the present study was to identify alterations in circulating metabol... |
2,329,869 | MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson's disease. | Parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra with no effective cure available. MicroRNA-124 has been regarded as a promising therapeutic entity for Parkinson's disease due to its pro-neurogenic and neuroprotective roles. However, its effici... |
2,329,870 | Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein. | The brain requires iron for a number of processes, including energy production. Inadequate or excessive amounts of iron can be detrimental and lead to a number of neurological disorders. As such, regulation of brain iron uptake is required for proper functioning. Understanding both the movement of iron into the brain a... |
2,329,871 | Automated Diagnosis and Assessment of Cardiac Structural Alteration in Hypertension Ultrasound Images. | Hypertension (HTN) is a major risk factor for cardiovascular diseases. At least 45% of deaths due to heart disease and 51% of deaths due to stroke are the result of hypertension. According to research on the prevalence and absolute burden of HTN in India, HTN positively correlated with age and was present in 20.6% of m... |
2,329,872 | Morphology of the distal tip of the spinal cord in Alligator mississippiensis. | Secondary neurulation is a common feature of vertebrate development, which in non-mammalian and non-anuran vertebrates, results in the formation of a caudal spinal cord. The present study was undertaken to describe the terminal end of the caudal spinal cord in a crocodylian, a group chosen for their unique status of a ... |
2,329,873 | Targeting the Subventricular Zone to Promote Myelin Repair in the Aging Brain. | The subventricular zone (SVZ) is the largest and most active germinal zone in the adult forebrain. Neural stem cells (NSCs) of the SVZ generate olfactory interneurons throughout life and retain the intrinsic ability to generate oligodendrocytes (OLs), the myelinating cells of the central nervous system. OLs and myelin ... |
2,329,874 | Release of Endocannabinoids into the Cerebrospinal Fluid during the Induction of the Trigemino-Hypoglossal Reflex in Rats. | The endocannabinoid system (ECS) plays an important role in pain processing and modulation. Since the specific effects of endocannabinoids within the orofacial area are largely unknown, we aimed to determine whether an increase in the endocannabinoid concentration in the cerebrospinal fluid (CSF) caused by the peripher... |
2,329,875 | Chronic Stress and Ovulatory Dysfunction: Implications in Times of COVID-19. | Stress is known to be associated with adverse health outcomes. The COVID-19 pandemic and its associated lockdowns are examples of chronic stressors. Lockdown measures inadvertently caused significant psychological distress and became a powerful source of anxiety/stress, sleep disturbances, nutritional changes and weigh... |
2,329,876 | Interindividual variation in maximum aerobic metabolism varies with gill morphology and myocardial bioenergetics in Gulf killifish.<ELocationID EIdType="pii" ValidYN="Y">jeb243680</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1242/jeb.243680</ELocationID><Abstract><AbstractText>This study asked whether interin... | This study asked whether interindividual variation in maximum and standard aerobic metabolic rates of the Gulf killifish, Fundulus grandis, correlates with gill morphology and cardiac mitochondrial bioenergetics, traits reflecting critical steps in the O2 transport cascade from the environment to the tissues. Maximum m... |
2,329,877 | Solitary metastasis from renal cell carcinoma to the choroid plexus: A case illustration and review of the literature. | Metastatic renal cell carcinoma (RCC) of the choroid plexus is an exceedingly rare condition, with only 35 reported cases to date. Surgical resection of these tumors poses a unique challenge to neurosurgeons since evidence-based treatment guidelines are yet to be designed.</AbstractText>The authors describe the case of... |
2,329,878 | Tension pneumoventricle in a patient with a ventriculoperitoneal shunt and an ethmoidal meningoencephalocele. | Tension pneumoventricle is a rare, life-threatening complication. It has been rarely described in patients with ventriculoperitoneal (VP) shunts.</AbstractText>A 28-year-old male patient with a VP shunt became progressively lethargic after falling from his wheelchair. Skull X-rays and head CT scan showed abundant air i... |
2,329,879 | Anatomic variations of the floor of the third ventricle: Surgical implications for endoscopic third ventriculostomy. | Endoscopic third ventriculostomy (ETV) is currently used as a treatment for different types of hydrocephalus. However, the anatomical endoscopic variants of the third ventricle floor (3VF), as well as their surgical implications, have been underrated. The anatomic variations of the 3VF can influence the technique and t... |
2,329,880 | Dosimetric Planning Comparison for Left-Sided Breast Cancer Radiotherapy: The Clinical Feasibility of Four-Dimensional-Computed Tomography-Based Treatment Planning Optimization. | Adjuvant whole-breast radiotherapy (RT) is a significant part of the standard of care treatment after breast cancer (BC) conserving surgery. Modern techniques including intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) have constituted to better target coverage and critical organs... |
2,329,881 | Vascular network expansion, integrity of blood-brain interfaces, and cerebrospinal fluid cytokine concentration during postnatal development in the normal and jaundiced rat. | Severe neonatal jaundice resulting from elevated levels of unconjugated bilirubin in the blood induces dramatic neurological impairment. Central oxidative stress and an inflammatory response have been associated with the pathophysiological mechanism. Cells forming the blood-brain barrier and the choroidal blood-CSF bar... |
2,329,882 | Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping. | Knowledge of the entry receptors responsible for SARS-CoV-2 is key to understand the neural transmission and pathogenesis of COVID-19 characterized by a neuroinflammatory scenario. Understanding the brain distribution of angiotensin converting enzyme 2 (ACE2), the primary entry receptor for SARS-CoV-2, remains mix... |
2,329,883 | Patient-specific computational fluid dynamic simulation of cerebrospinal fluid flow in the intracranial space. | Abnormal cerebrospinal fluid (CSF) flow is associated with a variety of poorly understood neurological disorders such as Alzheimer's Disease and hydrocephalus. The lack of comprehensive understanding of the fluid and solid mechanics of CSF flow remains a critical barrier in the development of diagnostic assessment and ... |
2,329,884 | Extensive myocardial calcification in critically ill patients receiving extracorporeal membrane oxygenation: A case report. | Myocardial calcification is a rare complication in critically ill patients. The prognosis of myocardial calcifications in critically ill patients is very poor if not treated in a timely manner. We describe a rare case of acute extensive myocardial calcifications due to acute myocarditis after receiving extracorporeal m... |
2,329,885 | Alpha-L-iduronidase deficiency: A novel mutation resulting in severe early presentation of Mucopolysaccharidosis type I and literature review of the molecular basis. | The <i>IDUA</i> gene (MIM 252800) provides instructions for producing alpha-L-iduronidase, which is essential for the breakdown of large sugar molecules called glycosaminoglycans (GAGs). Mutations in the <i>IDUA</i> gene have been found to cause Mucopolysaccharidosis type I (MPS I) (MIM 607014). Thi... |
2,329,886 | Altered Neuroanatomical Signatures of Patients With Treatment-Resistant Schizophrenia Compared to Patients With Early-Stage Schizophrenia and Healthy Controls. | The relationship between brain structural changes and cognitive dysfunction in schizophrenia is strong. However, few studies have investigated both neuroanatomical abnormalities and cognitive dysfunction in treatment-resistant schizophrenia (TRS). We examined neuroanatomical markers and cognitive function between patie... |
2,329,887 | Necrostatin-1 decreases necroptosis and inflammatory markers after intraventricular hemorrhage in mice. | Necrostatin-1, an inhibitor of necroptosis, can effectively inhibit necrotic apoptosis in neurological diseases, which results in the inhibition of inflammation, endoplasmic reticulum stress, and reactive oxygen species production and substantial improvement of neurological function. However, the effects of necrostatin... |
2,329,888 | Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic Analyses. | Although transcriptomic studies of SARS-CoV-2-infected brains have depicted variability in gene expression, the landscape of deregulated cell-specific regulatory circuits has not been elucidated yet. Hence, bulk and single-cell RNA-seq data are analyzed to gain detailed insights. Initially, two ceRNA networks with 19 a... |
2,329,889 | RBP-J deficiency promoted the proliferation and differentiation of CD133-positive cells in both in vitro and in vivo studies. | Although Notch signalling pathway could control the proliferation and differentiation of neural stem cells (NSCs), it is largely unknown about the effect of Notch signalling pathway on the neurogenesis of CD133-positive cells. By using the primary cultured ependymal cells and the transgenic mouse, we found that CD133 i... |
2,329,890 | Prevalence and Associated Factors of Long-term Growth Failure in Infants with Congenital Heart Disease Who Underwent Cardiac Surgery Before the Age of One.<Pagination><StartPage>1681</StartPage><EndPage>1687</EndPage><MedlinePgn>1681-1687</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00246-02... | Long-term growth failure can have negative impact on health (by increasing morbidity and mortality) and on neurodevelopmental outcomes. Its prevalence among children with congenital heart disease (CHD) is not well described. The aim of our study was to evaluate the prevalence of growth failure in a population of infant... |
2,329,891 | DNA-methylome-assisted classification of patients with poor prognostic subventricular zone associated IDH-wildtype glioblastoma. | Glioblastoma (GBM) derived from the "stem cell" rich subventricular zone (SVZ) may constitute a therapy-refractory subgroup of tumors associated with poor prognosis. Risk stratification for these cases is necessary but is curtailed by error prone imaging-based evaluation. Therefore, we aimed to establish a robust DNA m... |
2,329,892 | Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus. | Dysregulation of brain fluid homeostasis associates with brain pathologies in which fluid accumulation leads to elevated intracranial pressure. Surgical intervention remains standard care, since specific and efficient pharmacological treatment options are limited for pathologies with disturbed brain fluid homeostasis. ... |
2,329,893 | Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. | Congenital hydrocephalus occurs with some inheritable characteristics, but the mechanisms of its development remain poorly understood. Animal models provide the opportunity to identify potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one of the most studied animal models for inve... |
2,329,894 | Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF. | Guanidinoacetate (GAA) induces epileptogenesis and neurotoxicity in the brain. As epileptic animal models have been reported to show elevated cerebral GAA levels, the processing mechanism of GAA in the brain is important for maintaining brain homeostasis. We have revealed that GAA in the cerebrospinal fluid (CSF) is re... |
2,329,895 | Genome size drives morphological evolution in organ-specific ways.<Pagination><StartPage>1453</StartPage><EndPage>1468</EndPage><MedlinePgn>1453-1468</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/evo.14519</ELocationID><Abstract><AbstractText>Morphogenesis is an emergent property of biochemica... | Morphogenesis is an emergent property of biochemical and cellular interactions during development. Genome size and the correlated trait of cell size can influence these interactions through effects on developmental rate and tissue geometry, ultimately driving the evolution of morphology. We tested whether variation in ... |
2,329,896 | Myocardial Iron Deficiency and Mitochondrial Dysfunction in Advanced Heart Failure in Humans. | Background Myocardial iron deficiency (MID) in heart failure (HF) remains largely unexplored. We aim to establish defining criterion for MID, evaluate its pathophysiological role, and evaluate the applicability of monitoring it non-invasively in human explanted hearts. Methods and Results Biventricular tissue iron leve... |
2,329,897 | Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.<Pagination><StartPage>2081</StartPage><EndPage>2095</EndPage><MedlinePgn>2081-2095</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/epi.17316</ELocationID><Abstract><AbstractText Label="OBJE... | Torsion of wandering spleen after the Fontan operation with situs inversus is rare.Here, we report the case of a 6-year-old girl with a single ventricle and complete situs inversus who developed torsion of wandering spleen due to splenomegaly caused by post-operative haemodynamics of the Fontan operation. The platelet ... |
2,329,898 | Cerebellar Abnormalities on Proton MR Spectroscopy and Imaging in Patients With Gluten Ataxia: A Pilot Study. | Gluten ataxia is a rare immune-mediated neurological disorder caused by the ingestion of gluten. The diagnosis is not straightforward as antibodies are present in only up to 38% of patients, but often at lower titers. The symptoms of ataxia may be mild at the onset but lead to permanent damage if remain untreated. It i... |
2,329,899 | Diaphragmatic Pacing as an Initial Presentation of Delayed Ventricular Lead Perforation. | Ventricular lead perforation is an infrequent and potentially fatal complication of pacemakers and implantable cardioverter-defibrillators that typically presents shortly following device implantation. Delayed lead perforations occurring 1 month after implantation are not widely reported and can have a wide range of pr... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.