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2,332,700 | Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia. | Intrathecal (IT) opioid and local anesthetic combinations are popular for labor analgesia because of rapid, effective pain relief, but the duration of analgesia is limited. This study was undertaken to determine whether the addition of clonidine and neostigmine to IT bupivacaine-fentanyl would increase the duration of ... |
2,332,701 | Block of human heart hH1 sodium channels by amitriptyline. | Amitriptyline is a tricyclic antidepressant used to treat major depression and various neuropathic pain syndromes. This drug also causes cardiac toxicity in patients with overdose. We characterized the tonic and use-dependent amitriptyline block of human cardiac (hH1) Na(+) channels expressed in human embryonic kidney ... |
2,332,702 | Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys. | A radiolabeled human neutrophil elastase inhibitor (EPI-HNE-2) may represent an improved nuclear medicine imaging agent for inflammation and infection. This peptide displays rapid pharmacokinetics due to its low molecular weight and localizes specifically on neutrophil elastase released in inflammatory sites by activat... |
2,332,703 | Linkage of hereditary distal myopathy with desmin accumulation to 2q. | We are investigating the genetics of a large family with an autosomal dominant form of hereditary distal myopathy. This slowly progressive myopathy begins during early adulthood in the distal leg muscles, producing a gait disturbance. Cardiomyopathy is also present in most affected family members, manifesting itself as... |
2,332,704 | Effect of vitamin E sources (RRR- or all-rac-alpha-tocopheryl acetate) and levels on sow reproductive performance, serum, tissue, and milk alpha-tocopherol contents over a five-parity period, and the effects on the progeny. | Two dietary sources of vitamin E (DL-alpha-tocopheryl acetate [DL-beta-TAc], or D-alpha-tocopheryl acetate [DL-alpha-TAc]) at two dietary supplemental levels (30 vs 60 IU/kg) were evaluated in reproducing sows over a five-parity period. The experiment was a 2 x 2 factorial arrangement of treatments conducted as a rando... |
2,332,705 | A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. | Membrane-impermeant quaternary derivatives of lidocaine (QX222 and QX314) block cardiac Na(+) channels when applied from either side of the membrane, but they block neuronal and skeletal muscle channels poorly from the outside. To find the molecular determinants of the cardiac external QX access path, mutations of adul... |
2,332,706 | The effect of Portuguese Man-of-war (Physalia physalis) venom on calcium, sodium and potassium fluxes of cultured embryonic chick heart cells. | Portuguese Man-of-war venom markedly increases calcium (45Ca2+) influx into primary, cultured, embryonic chick heart cells. This action is dose-dependent, but is unaffected by organic calcium blockers (diltiazem, verapamil, nifedipine, nimodipine and mibefradil). On the other hand, certain trivalent (La3+, Gd3+) and di... |
2,332,707 | Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. | Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Studies of cultured neural cells suggest that PS1 mutations result in perturbed cellular calcium homeostasis and may thereby render neurons vulnerable to apoptosis. In light of evidence that metabolic im... |
2,332,708 | Rectal cancer in pregnancy: a new management based on blended anesthesia and monitoring of fetal well being. | Colorectal carcinoma presenting during pregnancy is an extremely rare condition associated with a poor prognosis. In this report we studied a patient referred to our hospital at 26 weeks of gestation with the diagnosis of rectal adenocarcinoma. Tumor resection with a colostomy was planned in the attempt to preserve pre... |
2,332,709 | [Effect of stellate ganglion block on human retinal blood flow]. | The effect of stellate ganglion block (SGB) on human retinal blood flow was evaluated.</AbstractText>We measured the diameter of the retinal artery and vein, and retinal venous flow rate by laser speckle retinal blood flow meter simultaneously in 11 eyes of 11 normal volunteers.</AbstractText>The reliable data from 9 e... |
2,332,710 | Subdivision of the cardiac Nkx2.5 expression domain into myogenic and nonmyogenic compartments. | Nkx2.5 is expressed in the cardiogenic mesoderm of avian, mouse, and amphibian embryos. To understand how various cardiac fates within this domain are apportioned, we fate mapped the mesodermal XNkx2.5 domain of neural tube stage Xenopus embryos. The lateral portions of the XNkx2.5 expression domain in the neural tube ... |
2,332,711 | Kearns-Sayre syndrome presenting as 2-oxoadipic aciduria. | A patient with 2-oxoadipic aciduria and 2-aminoadipic aciduria presented at 2 years of age with manifestations typical of organic acidemia, episodes of ketosis and acidosis, progressive to coma. This resolved and the key metabolites disappeared from the urine and blood. At 9 years of age she developed typical Kearns-Sa... |
2,332,712 | Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. | Cell death is an early and common event in the pathogenesis associated with the abnormal development induced by a variety of teratogens. Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apo... |
2,332,713 | Caspase activation and mitochondrial cytochrome C release during hypoxia-mediated apoptosis of adult ventricular myocytes. | Oxygen deprivation for prolonged periods leads to cardiac cell death and ventricular dysfunction. The ability to prevent myocardial cell death would be of significant therapeutic value in maintaining cardiac function after injury. While caspases have been suggested to play a critical role in apoptosis, their involvemen... |
2,332,714 | Catecholaminergic activity and 3',5'-cyclic adenosine monophosphate levels in heart right ventricle after naloxone induced withdrawal. | This study evaluated the adaptive changes in noradrenergic neurons and the concomitant production of cAMP during morphine dependence and withdrawal in the right ventricle of the rat. Rats were made dependent on morphine by morphine pellet implantation for 7 days. On the day of sacrifice animals received an acute inject... |
2,332,715 | Prevention of hypotension by a single 5-mg dose of ephedrine during small-dose spinal anesthesia in prehydrated cesarean delivery patients. | To evaluate the effectiveness of prophylactic ephedrine for the prevention of hypotension associated with spinal anesthesia, 50 parturients undergoing cesarean delivery received either ephedrine 5 mg or saline IV in a double-blinded fashion immediately after the induction of spinal anesthesia. Spinal anesthesia was per... |
2,332,716 | Short-term and long-term blood pressure and heart rate variability in the mouse. | Knowledge on murine blood pressure and heart rate control mechanisms is limited. With the use of a tethering system, mean arterial pressure (MAP) and pulse interval (PI) were continuously recorded for periods up to 3 wk in Swiss mice. The day-to-day variation of MAP and PI was stable from 5 days after surgery. Within e... |
2,332,717 | Roles of mitochondrial ATP-sensitive K channels and PKC in anti-infarct tolerance afforded by adenosine A1 receptor activation. | This study intended to assess the role of mitochondrial ATP-sensitive potassium (mitoK ATP) channels and the sequence of signal transduction with protein kinase C (PKC) and adenosine A1 receptors in rabbits.</AbstractText>To our knowledge, the link between trigger receptors of preconditioning, PKC and mitoK ATP channel... |
2,332,718 | Anesthetic efficacy and heart rate effects of the intraosseous injection of 3% mepivacaine after an inferior alveolar nerve block. | The purpose of this study was to determine the anesthetic efficacy and heart rate effects of an intraosseous injection of 3% mepivacaine after an inferior alveolar nerve block.</AbstractText>Through use of a repeated-measures design, each of 48 subjects randomly received 2 combinations of injections at 2 separate appoi... |
2,332,719 | Effects of a selective inhibitor of Na+/Ca2+ exchange, KB-R7943, on reoxygenation-induced injuries in guinea pig papillary muscles. | The effects of a novel agent that is reported to selectively block Ca2+ influx by Na+/Ca2+ exchange (NCX), KB-R7943, on the reoxygenation-induced arrhythmias and the recovery of developed tension after reoxygenation, were investigated in guinea pig papillary muscles. KB-R7943 dose-dependently suppressed the contracture... |
2,332,720 | Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. | Our aim was to measure the influence of sarcoplasmic reticulum (SR) calcium content ([Ca](SRT)) and free SR [Ca] ([Ca](SR)) on the fraction of SR calcium released during voltage clamp steps in isolated rabbit ventricular myocytes. [Ca](SRT), as measured by caffeine application, was progressively increased by conditioni... |
2,332,721 | Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels. | The voltage-gated potassium channel KCNQ1 associates with the small KCNE1 subunit to form the cardiac IKs delayed rectifier potassium current and mutations in both genes can lead to the long QT syndrome. KCNQ1 can form functional homotetrameric channels, however with drastically different biophysical properties compare... |
2,332,722 | Isoform-specific lidocaine block of sodium channels explained by differences in gating. | When depolarized from typical resting membrane potentials (V(rest) approximately -90 mV), cardiac sodium (Na) currents are more sensitive to local anesthetics than brain or skeletal muscle Na currents. When expressed in Xenopus oocytes, lidocaine block of hH1 (human cardiac) Na current greatly exceeded that of mu1 (rat... |
2,332,723 | Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection. | Although mononuclear cell infiltration is a hallmark of cellular rejection of a vascularized allograft, efforts to inhibit rejection by blocking leukocyte-endothelial cell adhesion have proved largely unsuccessful, perhaps in part because of persistent generation of chemokines within rejecting grafts. We now provide, t... |
2,332,724 | Comparative analgesic and cardiopulmonary effects of bupivacaine and ropivacaine in the epidural space of the conscious dog. | To compare the cardiopulmonary effects and sensory blockade of epidural bupivacaine and ropivacaine.</AbstractText>Prospective randomized study.</AbstractText>Six young adult medium-sized crossbred dogs weighing 25.7 ± 7.1 kg.</AbstractText>Dogs were chronically implanted with a lumbosacral epidural catheter. Acep... |
2,332,725 | Cellular and in vivo electrophysiological effects of dronedarone in normal and postmyocardial infarcted rats. | We studied the effects of dronedarone (SR 33589) on the action potentials, membrane ionic currents, and arrhythmic activity in control rats and in rats after myocardial infarction, a model known to develop anomalous electrical activity. Dronedarone increased action potential duration in normal hearts. It had little eff... |
2,332,726 | Caudal bupivacaine vs bupivacaine plus tramadol in post-operative analgesia in children. | Caudal analgesia with bupivacaine is used commonly for pain relief in children and extradural administration of tramadol seemed to be a safe method of analgesia. The aim of the study is to compare the analgesic efficacy of caudal bupivacaine and bupivacaine and tramadol mixture for postoperative analgesia and to observ... |
2,332,727 | Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning. | We present a case of oleander leaf extract poisoning manifested by vomiting, lightheadedness, and heart block. Practicing physicians should understand the potential lethal properties of oleander and its availability throughout the world. |
2,332,728 | Sex, drugs, and cognition: effects of marijuana. | Despite the knowledge that many drugs affect men and women differently, few studies exploring the effects of marijuana use on cognition have included women. Findings from both animal and human studies suggest marijuana may have more marked effects in women. This study examined sex differences in the acute effects of ma... |
2,332,729 | [Computer simulations of pacemaker shift in the sinoatrial node].<Pagination><StartPage>1132</StartPage><EndPage>1137</EndPage><MedlinePgn>1132-7</MedlinePgn></Pagination><Abstract><AbstractText>The initiation and propagation of electrical pulses in the sinoatrial node under normal conditions and after the application ... | The initiation and propagation of electrical pulses in the sinoatrial node under normal conditions and after the application of acetylcholine have been simulated. It has been found that normally a single or a few leading centers are formed in the tissue. When acetylcholine is applied, a temporary functional block of co... |
2,332,730 | Rami Communicans Nerve Block for the Treatment of Symptomatic Schmorl's Nodes -A Case Report-. | Histologically, Schmorl's nodes are defined as the loss of nuclear material through the cartilage plate, growth plate, and end plate into the vertebral body. Most Schmorl's nodes are asymptomatic, although there are some reports of symptomatic Schmorl's nodes, which should be treated similarly to vertebral compression ... |
2,332,731 | [A clinical research about the effect of vagus nerve block in cervical part to prevent Oculocardiac Reflex]. | To investigate the preventive effect of vagus nerve block in cervical part on Oculocardiac Reflex (OCR).</AbstractText>Case control study. 40 patients undergoing prosthesis of right orbital wall bone fracture were randomly divided into two groups: experiment group (group I) and control group (group II). Both of the gro... |
2,332,732 | The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs. | This study examined whether pro-2-PAM, a pro-drug dihydropyridine derivative of the oxime 2-pralidoxime (2-PAM) that can penetrate the brain, could prevent or reverse the central toxic effects of three nerve agents; sarin, cyclosarin, and VX. The first experiment tested whether pro-2-PAM could reactivate guinea pig cho... |
2,332,733 | Genetic parameters for direct and maternal effects on post-weaning body measurements of Muzaffarnagari sheep in India. | Variance components and genetic parameters were estimated for post-weaning (i.e., at 6, 9, and 12 months of age) body measurements in Muzaffarnagari sheep maintained at the Central Institute for Research on Goats, Makhdoom, Mathura, India over a period of 29 years (1976 through 2004). Records of 2,965 lambs descended f... |
2,332,734 | Endoscopic left sympathetic blockade in the treatment for dilated cardiomyopathy.<Pagination><StartPage>685</StartPage><EndPage>690</EndPage><MedlinePgn>685-90</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0066-782X2010005000152</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BAC... | Historically, heart, liver, and kidney biopsies were performed to demonstrate amyloid deposits in amyloidosis. Since the clinical presentation of this disease is so variable and non-specific, the associated risks of these biopsies are too great for the diagnostic yield. Other sites that have a lower biopsy risk, such a... |
2,332,735 | [Comparison of the influences of continuous femoral nerve block and patient controlled intravenous analgesia on total knee arthroplasty]. | To assess the influences of continuous femoral nerve block (CFNB) and patient-controlled intravenous analgesia (PCIA) on postoperative pain scores,knee rehabilitation,and stress response after total knee arthroplasty (TKA).</AbstractText>Totally 32 adult patients scheduled for elective total knee arthroplasty were equa... |
2,332,736 | [Anesthesia in a patient with Ellis-van Creveld syndrome]. | Ellis-van Creveld syndrome is a rare type of developmental chondroectodermal dysplasia. We report the case of a 32-year-old woman with this syndrome who was scheduled for cesarean section. She had no related heart defect. A spinal block was attempted but after confirming that no sensory blockade had been achieved, gene... |
2,332,737 | Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease. | Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens. This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of atherosclerotic plaques. In vascular tissues, scavenger receptors ar... |
2,332,738 | Differences in posture-movement changes induced by repetitive arm motion in healthy and shoulder-injured individuals. | Neck/Shoulder pain is linked to movement repetition, awkward postures, prolonged maintenance of static postures, and muscular fatigue. Studies have examined the influence of pain and fatigue on movement characteristics, but few reported multi-dimensional adaptations to movement repetition. We compared the adaptations m... |
2,332,739 | Thoracic epidural anesthesia and analgesia during the perioperative period of thoracic surgery: levobupivacaine versus bupivacaine. | To compare the effects of thoracic epidural anesthesia with levobupivacaine or bupivacaine on block features, intraoperative hemodynamics, and postoperative analgesia for thoracic surgery.</AbstractText>A prospective, randomized, and double-blind study.</AbstractText>A university hospital.</AbstractText>Fifty patients ... |
2,332,740 | Quantification and identification of mitochondrial proteins containing vicinal dithiols. | Vicinal dithiols may play a role in mitochondrial antioxidant defences and in redox signalling. We quantified protein vicinal dithiols within mammalian mitochondria using the vicinal dithiol-specific reagent phenylarsine oxide (PAO). We found 5-15% of thiols exposed on mitochondrial proteins were vicinal dithiols and t... |
2,332,741 | Role of surface protein SasG in biofilm formation by Staphylococcus aureus. | The SasG surface protein of Staphylococcus aureus has been shown to promote the formation of biofilm. SasG comprises an N-terminal A domain and repeated B domains. Here we demonstrate that SasG is involved in the accumulation phase of biofilm, a process that requires a physiological concentration of Zn(2+). The B domai... |
2,332,742 | Addition of low-dose morphine to intrathecal bupivacaine/sufentanil labour analgesia: A randomised controlled study. | Single-shot spinal analgesia with bupivacaine and a short-acting opioid for labour pain is popular due to its simplicity, rapid onset, and profound analgesia without significant motor block. Its limitation is the short duration of action. Supplementation with intrathecal morphine has been shown to prolong analgesia. We... |
2,332,743 | How different two almost identical action potentials can be: a model study on cardiac repolarization. | Spatial heterogeneity in the properties of ion channels generates spatial dispersion of ventricular repolarization, which is modulated by gap junctional coupling. However, it is possible to simulate conditions in which local differences in excitation properties are electrophysiologically silent and only play a role in ... |
2,332,744 | HIV protease inhibitors elicit volume-sensitive Cl- current in cardiac myocytes via mitochondrial ROS. | HIV protease inhibitors (HIV PI) reduce morbidity and mortality of HIV infection but cause multiple untoward effects. Because certain HIV PI evoke production of reactive oxygen species (ROS) and volume-sensitive Cl(-) current (I(Cl,swell)) is activated by ROS, we tested whether HIV PI stimulate I(Cl,swell) in ventricul... |
2,332,745 | Efficacy of bupivacaine-neostigmine and bupivacaine-tramadol in caudal block in pediatric inguinal herniorrhaphy. | Limited duration of analgesia is among the limitations of single caudal injection with local anesthetics. Therefore, the purpose of this study was to evaluate the effectiveness and safety of bupivacaine in combination with either neostigmine or tramadol for caudal block in children undergoing inguinal herniorrhaphy.</A... |
2,332,746 | Post-operative analgesia following total knee arthroplasty: comparison of low-dose intrathecal morphine and single-shot ultrasound-guided femoral nerve block: a randomized, single blinded, controlled study. | Total knee arthroplasty often results in marked postoperative pain. A recent meta-analysis supports the use of femoral nerve block or alternatively spinal injection of morphine plus local anaesthetic for post-operative analgesia. On the other hand, the use of intrathecal morphine may be associated with a large number o... |
2,332,747 | Transplantation in Hungary--preface on the occasion of Transplantation Proceedings becoming the official journal of the Hungarian Transplantation Society. | The first, long-term successful kidney transplantation happened 37 years ago in Hungary. At the same time an organized renal program was initiated followed by transplantations of other solid organs. The authors remember previous milestone operations and the preceding events. In 1982, Hungary was the first country in th... |
2,332,748 | [Effect of yiqi huoxue recipe containing drug-serum on the Toll-Iike receptor-4 and its downstream signaling components MyD88 as well as the tumor necrosis factor receptor related factor-6 in human vein endothelial cells]. | To investigate the influence of Yiqi Huoxue Recipe (YHR) containing drug-serum on the expression of Toll-like receptor-4 (TLR4) and its downstream signaling components MyD88, as well as the tumor necrosis factor receptor related factor-6 (TRAF-6) in human vein endothelial cells (HUVECs) induced by lipopolysaccharide (L... |
2,332,749 | Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice. | The hypothesis that Na(+) influx during the action potential (AP) activates reverse Na(+)-Ca(2+) exchange (NCX) and subsequent entry of trigger Ca(2+) is controversial. We tested this hypothesis by monitoring intracellular Ca(2+) before and after selective inactivation of I(Na) prior to a simulated action potential in ... |
2,332,750 | Caudal epidural block in children: comparison of needle insertion parallel with caudal canal versus conventional two-step technique. | This study compared the technique of inserting the needle for caudal epidural blockade in a single pass parallel to the caudal canal versus the conventional technique of approaching the caudal canal with the needle at a steeper angle. Seventy-five patients, aged 0 to 72 months, scheduled for urological surgery were pro... |
2,332,751 | The changes of heart rate variability after unilateral stellate ganglion block. | The effect of the unilateral stellate ganglion block (SGB) on cardiovascular regulation remains controversial. We wished to evaluate the changes in heart rate variability (HRV) after a unilateral stellate ganglion block in patients with head and neck pain in the present study.</AbstractText>Patients with head and neck ... |
2,332,752 | Effect of ramosetron on shivering during spinal anesthesia. | Shivering associated with spinal anesthesia is uncomfortable and may interfere with monitoring. The aim of this study is to evaluate the effect of ramosetron, a serotonin-3 receptor antagonist, on the prevention of shivering during spinal anesthesia.</AbstractText>We enrolled 52 patients who were ASA I or II and who ha... |
2,332,753 | BAFF mediates splenic B cell response and antibody production in experimental Chagas disease. | B cells and antibodies are involved not only in controlling the spread of blood circulating Trypanosoma cruzi, but also in the autoreactive manifestations observed in Chagas disease. Acute infection results in polyclonal B cell activation associated with hypergammaglobulinemia, delayed specific humoral immunity and hig... |
2,332,754 | First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes. | The Yersinia adhesin YadA mediates the adhesion of the human enteropathogen Yersinia enterocolitica to collagens and other components of the extracellular matrix. Though YadA has been proposed to bind to a specific site in collagens, the exact binding determinants for YadA in native collagen have not previously been el... |
2,332,755 | Comparison of spinal, low-dose spinal and epidural anesthesia with ropivacaine plus fentanyl for transurethral surgical procedures. | The aim of This study was to compare spinal, low-dose spinal, and epidural anesthesia using ropivacaine and fentanyl combinations for transurethral surgical procedures. Sixty patients with American Society of Anesthesiologists scores of I-III were allocated into three groups. After pre- loading with 5 mL/kg normal sali... |
2,332,756 | Levobupivacaine-tramadol combination for caudal block in children: a randomized, double-blinded, prospective study. | The aim of this prospective study was to compare the postoperative analgesic efficacy and duration of analgesia after caudal levobupivacaine 0.125% or caudal tramadol 1.5 mg.kg(-1) and mixture of both in children undergoing day-case surgery.</AbstractText>Sixty-three American Society of Anesthesiologists (ASA) I or II ... |
2,332,757 | MicroRNAs and the regulation of fibrosis. | MicroRNAs (miRNAs) are small, noncoding RNAs of 18-25 nucleotides that are generally believed to either block the translation or induce the degradation of target mRNA. miRNAs have been shown to play fundamental roles in diverse biological and pathological processes, including cell proliferation, differentiation, apopto... |
2,332,758 | Local adenosine receptor blockade accentuates the sympathetic responses to fatiguing exercise. | The role adenosine plays in evoking the exercise pressor reflex in humans remains controversial. We hypothesized that localized forearm adenosine receptor blockade would attenuate muscle sympathetic nerve activity (MSNA) responses to fatiguing handgrip exercise in humans. Blood pressure (Finometer), heart rate, and MSN... |
2,332,759 | Usurping the mitochondrial supremacy: extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion. | Insulin secretion from pancreatic beta cells is a process dependent on metabolism. While oxidative stress is a well-known inducer of beta cell toxicity and impairs insulin secretion, recent studies suggest that low levels of metabolically-derived reactive oxygen intermediates (ROI) also play a positive role in insulin ... |
2,332,760 | Peripheral blockade as treatment of arm ischaemia at birth. | Limbs ischaemia represents a rare event during the neonatal period. The present paper reports an unusual case of precocious arm ischemia that occurred immediately after birth and successfully treated with a peripheral nerve blockade.</AbstractText>Peripheral nerve blockade resulted in an effective and safe therapeutic ... |
2,332,761 | Ganglionic transmission in a vasomotor pathway studied in vivo. | Intracellular recordings were made in vivo from 40 spontaneously active cells in the third lumbar sympathetic ganglion of urethane-anaesthetized rats. In 38/40 cells ongoing action potentials showed strong cardiac rhythmicity (93.4 +/- 1.9% modulation) indicating high barosensitivity and probable muscle vasoconstrictor... |
2,332,762 | Prolonged pharmacodynamic effects of S-0139, an intravenously administered endothelin A (ET) antagonist, in the human forearm blood flow model. | To estimate the pharmacologically active dose range of a new investigational compound S-0139, a selective endothelin A (ET(A)) receptor antagonist, in man, and to examine the duration of its pharmacodynamic effect.</AbstractText>Venous occlusion plethysmography was performed to assess changes in forearm blood flow foll... |
2,332,763 | Comparison of combined spinal and general anesthesia block and combined epidural and general anesthesia block in laparoscopic cholecystectomy. | Combined spinal and general anesthesia block (CSGAB) and combined epidural and general anesthesia block (CEGAB) in laparoscopic cholecystectomy were compared.</AbstractText>Forty patients were randomly selected (ASA physical status I-II) to receive sevoflurane plus 10 to 15 mg of bupivacaine weighed at 0.5% and 20 micr... |
2,332,764 | A novel surgical approach to impacted mandibular third molars to reduce the risk of paresthesia: a case series. | Extraction of impacted mandibular third molars (M3s) may cause temporary or permanent neurosensorial disturbances of the inferior alveolar nerve (IAN). Although the incidence of this complication is low, a great range of variability has been reported in the literature. Several methods to reduce or eliminate this compli... |
2,332,765 | Clinical comparison of 12 mg ropivacaine and 8 mg bupivacaine, both with 20 microg fentanyl, in spinal anaesthesia for major orthopaedic surgery in geriatric patients. | The aim of this study was to compare the haemodynamic and anaesthetic effects of 12 mg ropivacaine and 8 mg bupivacaine, both with 20 microg fentanyl, in spinal anaesthesia for major orthopaedic surgery in geriatric patients.</AbstractText>Sixty American Society of Anesthesiologists (ASA) II-III patients scheduled for ... |
2,332,766 | Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. | Electrical propagation in diseased and aging hearts is strongly influenced by structural changes that occur in both the intracellular and interstitial spaces of cardiac tissue; however, very few studies have investigated how interactions between the two spaces affect propagation at the microscale. In this study, we use... |
2,332,767 | Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. | Bone mineral density (BMD), a diagnostic parameter for osteoporosis and a clinical predictor of fracture, is a polygenic trait with high heritability. To identify genetic variants that influence BMD in different ethnic groups, we performed a genome-wide association study (GWAS) on 800 unrelated Southern Chinese women w... |
2,332,768 | [Minimally invasive surgical treatment with per-pancreat region for sever acute pancreatitis.].<Pagination><StartPage>1464</StartPage><EndPage>1467</EndPage><MedlinePgn>1464-7</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the clinical effect of the minimally i... | To investigate the clinical effect of the minimally invasive surgical treatment with per-pancreat region for sever acute pancreatitis (SAP).</AbstractText>Fify-four cases of SAP were divided into two groups, patients of group A (n = 28) were given minimally invasive surgical treatments (step 1: under local anesthesia, ... |
2,332,769 | TNFalpha and its receptors in psoriatic skin, before and after treatment with etanercept. | Psoriasis is a chronic inflammatory skin condition characterized by inflammatory dermal infiltrate and hyperproliferative keratinocytes. The pathogenesis of this disease is mediated by a dysregulation of the innate immunity and cytokine production. Tumor necrosis factor alpha (TNFalpha) is considered the most important... |
2,332,770 | Training characteristics of paralympic swimmers. | The ability to monitor training is critical to the process of quantifying training periodization plans, yet weekly patterns of volume and intensity for Paralympic swimmers before competition have not been reported. Sixteen swimmers were monitored prospectively over a 16-week training block constituting 4 training phase... |
2,332,771 | Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. | Large-conductance Ca(2+)-activated K(+) channels (BK(Ca)) in the inner mitochondrial membrane may play a role in protecting against cardiac ischemia-reperfusion injury. NS1619 (30 microM), an activator of BK(Ca) channels, was shown to increase respiration and to stimulate reactive oxygen species generation in isolated ... |
2,332,772 | Therapy-related myelodysplastic syndrome presenting as fulminant heart failure secondary to myeloid sarcoma.<Pagination><StartPage>41</StartPage><EndPage>46</EndPage><MedlinePgn>41-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s12308-010-0058-4</ELocationID><Abstract><AbstractText>Rapidly pr... | Rapidly progressive heart failure is commonly caused by an extensive myocardial infarction, a mechanical complication of infarction, myocarditis, or acute valvular insufficiency. We present an unusual case that was caused by a diffuse infiltration of the myocardium with leukemic cells (myeloid sarcoma). The patient pre... |
2,332,773 | Pain treatment in post-traumatic hip fracture in the elderly: regional block vs. systemic non-steroidal analgesics. | The renin-angiotensin system is a complex biologic system between the heart, brain, blood vessels, and kidneys that leads to the production of biologically active agents, including angiotensin I and II and aldosterone, which act together to impact a variety of bodily functions including blood vessel tone, sodium balanc... |
2,332,774 | [Experiment research of Jiajian Yunvjian granules on hyperthyroidism graves]. | To investigate the effects and the related mechanisms of Jiajian Yunujian (JJYNJ) granules, which were made from traditional Chinese medicinal prescription, on hyperthyroidism graves.</AbstractText>Except that in the normal group, all mice were injected 350 mcirog x kg x d(-1) L-Thyroxin sodium to establish the hyperth... |
2,332,775 | Gold-coated pacemaker implantation after allergic reactions to pacemaker compounds.<Pagination><StartPage>749</StartPage><EndPage>750</EndPage><MedlinePgn>749-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/europace/eup411</ELocationID><Abstract><AbstractText>An 86-year-old man underwent pace... | An 86-year-old man underwent pacemaker implantation for symptomatic atrio-ventricular block grade 2 Mobitz II. The patient suffered repeated admissions for iterative sterile wound necrosis, leading to two generator re-implantations. No bacterial infection was detected in the microbiological screening tests. The skin pa... |
2,332,776 | Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. | Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) generate ROS, and therefore this study evaluated the effects of RAGE deletion, decreasing AGE accumulation, or lowering dietary AGE content on oxidative parameters in diabetic nephropathy (DN). Control and diabetic male wild-type and RAGE-deficient... |
2,332,777 | Spread of subarachnoid sensory block with hyperbaric bupivacaine in second trimester of pregnancy. | To compare the spread of subarachnoid sensory block with hyperbaric bupivacaine in second trimester pregnant and non-pregnant women.</AbstractText>Prospective study.</AbstractText>University teaching hospital.</AbstractText>44 ASA physical status I and II women patients, 22 of whom were in their second trimester of pre... |
2,332,778 | Low-dose spinal hyperbaric bupivacaine for adult anorectal surgery: a double-blinded, randomized, controlled study. | To produce selective spinal anesthesia for adult anorectal surgery.</AbstractText>Double-blinded, randomized, controlled trial.</AbstractText>Operating room and postoperative recovery area.</AbstractText>152 adult, consecutive ASA physical status I, II, and III patients.</AbstractText>After patients underwent dural pun... |
2,332,779 | [Neuromuscular block monitoring for optimisation of conditions for endotracheal intubation]. | The choice of an appropriate moment for endotracheal intubation is essential to avoid serious motor and cardiovascular reactions during laryngoscopy and tube insertion.The purpose of the study was to compare the effects of intubation on laryngoscopy conditions and cardiovascular response, when choice of the moment for ... |
2,332,780 | Blood pressure, but not cerebrospinal fluid fentanyl concentration, predicts duration of labor analgesia from spinal fentanyl. | There is a wide variability in dilution of drugs in cerebrospinal fluid after spinal injection, as measured near the site of injection. With local anesthetics, there is a wide variability in speed of onset, which correlates with block duration. The authors tested whether local cerebrospinal fluid drug concentrations an... |
2,332,781 | Anaesthesia for total knee arthroplasty: efficacy of single-injection or continuous lumbar plexus associated with sciatic nerve blocks--a randomized controlled study. | Total knee arthroplasty (TKA) often results in marked postoperative pain. We compared in a randomized controlled study tramadol consumption, postoperative pain and patient satisfaction after primary TKA in patients who received a single injection lumbar plexus and sciatic nerve blocks or a continuous lumbar plexus and ... |
2,332,782 | [Effects of combined intercostal nerves block-sevoflurane used inhalation anesthesia with laryngeal mask ventilation on the stress response in patients suffered from breast neoplasms undergoing modified radical mastectomy]. | To investigate the influence of combined intercostal nerves block-sevoflurane used inhalation anesthesia with laryngeal mask ventilation on the stress response to modified radical mastectomy.</AbstractText>60 patients with ASA physical status I-II, aged 33-53 years and scheduled for modified radical mastectomy were ran... |
2,332,783 | The effects of adding various doses of clonidine to ropivacaine in spinal anesthesia. | In this study, we compared the clinical effects of combined doses of ropivacaine and clonidine.</AbstractText>Seventy-five patients between ages 18 and 75, in ASA I-III groups who were to undergo elective lower extremity surgery, were included in the study with informed consent. Subjects were randomly assigned to 3 gro... |
2,332,784 | Out-of-hospital cardiac arrest frequency and survival: evidence for temporal variability. | Some cardiac phenomena demonstrate temporal variability. We evaluated temporal variability in out-of-hospital cardiac arrest (OHCA) frequency and outcome.</AbstractText>Prospective cohort study (the Resuscitation Outcomes Consortium) of all OHCA of presumed cardiac cause who were treated by emergency medical services w... |
2,332,785 | Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair. | The effect of dexmedetomidine on the duration of sensory blockade has not been studied in humans. We evaluated the effect of adding dexmedetomidine to bupivacaine on the duration of postoperative analgesia in children who underwent repair of a cleft palate.</AbstractText>Thirty children who were scheduled for repair of... |
2,332,786 | Hepatic effects of thoracic epidural analgesia in experimental severe acute pancreatitis. | Thoracic epidural anesthesia (TEA) protects the intestinal microcirculation and improves perioperative outcomes. TEA also reduces mortality in acute experimental pancreatitis. Its impact on hepatic microcirculation, however, in health and critical illness is unknown. Therefore, the authors studied the effect of TEA on ... |
2,332,787 | Ketamine, but not priming, improves intubating conditions during a propofol-rocuronium induction. | Both ketamine and priming may shorten the onset time of rocuronium. This study investigates the effects of ketamine and priming as components of a propofol induction on intubating conditions and onset of neuromuscular block.</AbstractText>This prospective randomized double-blind study was performed in 120 American Soci... |
2,332,788 | The cardiovascular response to an acute 1800-microT, 60-Hz magnetic field exposure in humans. | Previously published literature has suggested an effect of extremely low-frequency (ELF) magnetic fields (MF) on human heart rate (HR) and heart rate variability (HRV). The combined response of the microcirculation and macrocirculation to ELF MF exposure has not previously been studied in humans. This study investigate... |
2,332,789 | Removal of real-time reverse transcription polymerase chain reaction (RT-PCR) inhibitors associated with cloacal swab samples and tissues for improved diagnosis of Avian influenza virus by RT-PCR. | Real-time reverse transcription polymerase chain reaction (real-time RT-PCR) is routinely used for the rapid detection of Avian influenza virus (AIV) in clinical samples, but inhibitory substances present in some clinical specimens can reduce or block PCR amplification. Most commercial RNA extraction kits have limited ... |
2,332,790 | I-TAC is a dominant chemokine in controlling skin intragraft inflammation via recruiting CXCR3+ cells into the graft. | Chemokines play a critical role in the acute transplant rejection. In order to provide an overview of the chemokine expression during the course of acute allograft rejection, the intragraft expression profile of 11 chemokines representative of all four chemokine subfamilies was analyzed in a murine skin transplantation... |
2,332,791 | The neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation. | The CUG-BP and ETR-3 like factors (CELF) are a family of six highly conserved RNA-binding proteins that preferentially bind to UG-rich sequences. One of the key functions of these proteins is to mediate alternative splicing in a number of tissues, including brain, heart and muscle. To fully understand the function of C... |
2,332,792 | Spread of spinal anesthesia in patients having perianal surgery in the jackknife position: effects of baricity of 0.5% bupivacaine and positioning during and after induction of spinal anesthesia. | To compare the influence of baricity and patient positioning during onset of subarachnoid block in patients placed in the prone, jackknife position with head-down tilt of 15 degrees .</AbstractText>Randomized study.</AbstractText>Operating room of Tonami General Hospital.</AbstractText>180 ASA physical I and II patient... |
2,332,793 | Three concentrations of levobupivacaine for ilioinguinal/iliohypogastric nerve block in ambulatory pediatric surgery. | To compare the postoperative analgesia of three different concentrations of levobupivacaine for ilioinguinal/iliohypogastric (II/IH) block in children undergoing inguinal hernia repair.</AbstractText>Double-blind, prospective, randomized, controlled trial.</AbstractText>Operating room and postoperative recovery area of... |
2,332,794 | Socioeconomic position and graft failure in pediatric heart transplant recipients. | Socioeconomic (SE) position may affect availability of resources, health-related behavior, and outcomes. We assessed whether patient SE position, determined for the block group of patient residence (average population 1000, smallest census unit with SE data), is associated with graft failure in pediatric heart transpla... |
2,332,795 | Some variations in lymphatic drainage of selected bronchopulmonary segments in human lungs. | Interest in the role of the pulmonary lymphatic system in the pathophysiology of pulmonary and systemic diseases induced us to carry out anatomical research on the lung lymphatic system in the Polish population. The aim of the study was to evaluate whether lymphatic vessels respect bronchopulmonary segment borders and ... |
2,332,796 | The effects of intravenous ephedrine during spinal anesthesia for cesarean delivery: a randomized controlled trial. | We designed a randomized, double-blinded study to determine the efficacy and safety of 0.5 mg/kg intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Patients were randomly allocated into two groups: ephedrine group (n=21) and control group (n=21). Intravenous preload ... |
2,332,797 | [Intraosseous anesthesia X-tip system in tooth extraction]. | The purpose of this study was to determine the anesthetic efficacy of a intraosseous anesthesia (IOA) as an alternative to the infra alveolar nerve block (IANB) or the maxillary anesthesia. 55 subjects who underwent a tooth extraction received a primary X-tip intraosseous injection (LLC Lakewood, New Jersey, U.S.A.) of... |
2,332,798 | Modafinil does not serve as a reinforcer in cocaine abusers. | The purpose of this double-blind, randomized, outpatient study was to evaluate the reinforcing and subjective effects of modafinil (200, 400, or 600 mg) in cocaine abusers. Twelve participants (2 female, 10 male) completed this study, consisting of 3 blocks of 7 sessions; each block tested a difference dose of modafini... |
2,332,799 | Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial. | In the post-intervention period of the Women's Health Initiative (WHI) trial, women assigned to treatment with oestrogen plus progestin had a higher risk of cancer than did those assigned to placebo. Results also suggested that the combined hormone therapy might increase mortality from lung cancer. To assess whether su... |
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